MCID: ACT093
MIFTS: 40

Actinic Cheilitis

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Actinic Cheilitis

MalaCards integrated aliases for Actinic Cheilitis:

Name: Actinic Cheilitis 52 71
Actinic Cheilosis 52

Classifications:



External Ids:

UMLS 71 C0267026

Summaries for Actinic Cheilitis

MalaCards based summary : Actinic Cheilitis, also known as actinic cheilosis, is related to lip cancer and suppressor of tumorigenicity 3. An important gene associated with Actinic Cheilitis is TP53 (Tumor Protein P53), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Regulation of TP53 Activity. The drugs Imiquimod and Aminolevulinic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, salivary gland and t cells, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and cellular

Wikipedia : 74 Actinic cheilitis is cheilitis (lip inflammation) caused by long term sunlight exposure. Essentially it... more...

Related Diseases for Actinic Cheilitis

Diseases related to Actinic Cheilitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
# Related Disease Score Top Affiliating Genes
1 lip cancer 29.7 TP53 MSH2 MDM2 CDKN1A
2 suppressor of tumorigenicity 3 29.7 TP53 CDKN1A BCL2
3 cheilitis 29.2 TP53 MSH2 MDM2 CDKN1A BCL2 APEX1
4 lymphoma, non-hodgkin, familial 29.0 TP53 MSH2 MDM2 BCL2
5 basal cell carcinoma 28.9 TP53 MSH2 MDM2 CDKN1A BCL2
6 keratosis 10.6
7 actinic keratosis 10.6
8 squamous cell carcinoma 10.6
9 in situ carcinoma 10.2
10 ring chromosome 7 10.2 TP53 MDM2
11 ring chromosome 10.2 TP53 MDM2
12 esophagus verrucous carcinoma 10.2 TP53 MDM2
13 verrucous carcinoma 10.2 TP53 MDM2
14 bone giant cell sarcoma 10.2 TP53 MDM2
15 maxillary sinus adenocarcinoma 10.2 TP53 MDM2
16 parameningeal embryonal rhabdomyosarcoma 10.2 TP53 MDM2
17 embryonal rhabdomyosarcoma 10.2 TP53 MDM2
18 embryonal sarcoma 10.2 TP53 MDM2
19 dedifferentiated liposarcoma 10.2 TP53 MDM2
20 conventional fibrosarcoma 10.2 TP53 MDM2
21 familial retinoblastoma 10.2 TP53 MDM2
22 uterine adnexa cancer 10.2 TP53 MDM2
23 anal squamous cell carcinoma 10.2 TP53 MDM2
24 neurofibromatosis, type ii 10.1
25 skin disease 10.1
26 superficial basal cell carcinoma 10.1
27 herpes simplex 10.1
28 albinism 10.1
29 leukoplakia 10.1
30 oral cancer 10.1
31 cataract 10.1
32 premature aging 10.1
33 invasive bladder transitional cell carcinoma 10.1 TP53 CDKN1A
34 bladder transitional cell papilloma 10.1 TP53 CDKN1A
35 bone osteosarcoma 10.1 TP53 MDM2
36 keratocystic odontogenic tumor 10.1 TP53 BCL2
37 gliomatosis cerebri 10.1 TP53 MDM2
38 connective tissue benign neoplasm 10.1 TP53 MDM2
39 testicular torsion 10.1 TP53 BCL2
40 cardia cancer 10.1 TP53 MDM2
41 skin papilloma 10.1 TP53 CDKN1A
42 focal cortical dysplasia, type ii 10.1 TP53 BCL2
43 cervical mucinous adenocarcinoma 10.1 TP53 MSH2
44 oral submucous fibrosis 10.1 TP53 MDM2
45 endometrioid ovary carcinoma 10.0 TP53 MSH2
46 extramedullary plasmacytoma 10.0 CDKN1A BCL2
47 endocervical adenocarcinoma 10.0 TP53 CDKN1A
48 chondromyxoid fibroma 10.0 CDKN1A BCL2
49 female reproductive endometrioid cancer 10.0 TP53 MSH2
50 osteochondroma 10.0 CDKN1A BCL2

Graphical network of the top 20 diseases related to Actinic Cheilitis:



Diseases related to Actinic Cheilitis

Symptoms & Phenotypes for Actinic Cheilitis

GenomeRNAi Phenotypes related to Actinic Cheilitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.1 APEX1 BCL2 CDKN1A MDM2 MSH2 TP53

MGI Mouse Phenotypes related to Actinic Cheilitis:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.97 APEX1 BCL2 CDKN1A MDM2 MSH2 TP53
2 digestive/alimentary MP:0005381 9.85 BCL2 CDKN1A MDM2 MSH2 TP53
3 homeostasis/metabolism MP:0005376 9.85 APEX1 BCL2 CDKN1A MDM2 MSH2 TP53
4 embryo MP:0005380 9.83 APEX1 BCL2 CDKN1A MDM2 TP53
5 endocrine/exocrine gland MP:0005379 9.8 APEX1 BCL2 CDKN1A MDM2 TP53
6 immune system MP:0005387 9.8 APEX1 BCL2 CDKN1A MDM2 MSH2 TP53
7 craniofacial MP:0005382 9.78 BCL2 CDKN1A MDM2 TP53
8 integument MP:0010771 9.65 BCL2 CDKN1A MDM2 MSH2 TP53
9 muscle MP:0005369 9.55 APEX1 BCL2 CDKN1A MDM2 TP53
10 neoplasm MP:0002006 9.43 APEX1 BCL2 CDKN1A MDM2 MSH2 TP53
11 reproductive system MP:0005389 9.02 APEX1 BCL2 CDKN1A MDM2 TP53

Drugs & Therapeutics for Actinic Cheilitis

Drugs for Actinic Cheilitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
2
Aminolevulinic acid Approved Phase 4 106-60-5 137
3 Adjuvants, Immunologic Phase 4
4 Methyl 5-aminolevulinate Phase 4
5 Immunologic Factors Phase 4
6 interferons Phase 4
7 Interferon Inducers Phase 4
8 Dermatologic Agents Phase 4
9 Photosensitizing Agents Phase 4
10
Prilocaine Approved Phase 1 721-50-6 4906
11
Lidocaine Approved, Vet_approved Phase 1 137-58-6 3676
12 Anesthetics, Local Phase 1
13 Anti-Arrhythmia Agents Phase 1
14 Anesthetics Phase 1
15 Sodium Channel Blockers Phase 1
16 Central Nervous System Depressants Phase 1
17 Diuretics, Potassium Sparing Phase 1
18 Lidocaine, Prilocaine Drug Combination Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Prospective Study Comparing 5% Imiquimod and Photodynamic Therapy for Actinic Cheilitis Completed NCT00849992 Phase 4 Imiquimod 5%
2 Photodynamic Therapy (PDT) With Levulan and Blue Light for the Treatment of Actinic Cheilitis Completed NCT02409732 Phase 4 aminolevulinic acid hydrochloride
3 A Clinical Trial of ALA Photodynamic Therapy for Treatment of Actinic Cheilitis in Patients With Squamous Cell Carcinoma of the Lip. Completed NCT00868088 Phase 4
4 Photodynamic Therapy With Metil 5-aminolevulinate for Actinic Cheilitis - A Phase 2 Randomized Double-blind Placebo Controlled Clinical Trial Not yet recruiting NCT03990636 Phase 2 Metil 5-aminolevulinate
5 Phase 1/2 Clinical Trial for the Evaluation of Ingenol Mebutate for Actinic Cheilitis Withdrawn NCT03452566 Phase 1, Phase 2 Ingenol mebutate gel
6 A Randomized, Prospective Study Comparing Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Ablative Fractional Laser Treatment for Actinic Cheilitis Completed NCT02198469 Phase 1 Er:YAG AFL-PDT;MAL-PDT
7 A Randomised Trial Comparing Methyl Aminolaevulinate Photodynamic Therapy With and Without Ablative Fractional Laser Treatment in Patients With Microinvasive Squamous Cell Carcinoma: Results From a 24-month Follow-up Completed NCT02666534 Phase 1 lidocaine-prilocaine 5% cream application;methyl-aminolevulinate application
8 Efficacy of Iontophoresis-assisted Ablative Fractional Laser Photodynamic Therapy With Short Incubation Time for the Treatment of Actinic Keratosis: 12-month Follow-up Results of a Prospective, Randomised, Comparative Trial Completed NCT02670655 Phase 1 lidocaine/prilocaine (5%) application;MAL application
9 Actinic Cheilitis Pre-Treated With DNA Repair Enzyme Cream Withdrawn NCT03224715

Search NIH Clinical Center for Actinic Cheilitis

Genetic Tests for Actinic Cheilitis

Anatomical Context for Actinic Cheilitis

MalaCards organs/tissues related to Actinic Cheilitis:

40
Skin, Salivary Gland, T Cells, Kidney, Testes, Nk Cells

Publications for Actinic Cheilitis

Articles related to Actinic Cheilitis:

(show top 50) (show all 298)
# Title Authors PMID Year
1
Proper management of suspicious actinic cheilitis. 61
31032237 2019
2
Detection of human papillomaviruses and human polyomaviruses in immunosuppressed and immunocompetent individuals with actinic cheilitis: a case series. 61
31281986 2019
3
High rate of clinical improvement of actinic cheilitis with laser, surgery, and chemotherapeutic agents in patients who have a favorable prognosis. 61
31519297 2019
4
Patch Testing for Cheilitis: A 10-Year Series. 61
31609855 2019
5
Fludroxycortide cream as an alternative therapy for actinic cheilitis. 61
30673866 2019
6
Actinic cheilitis: Morphometric parameters and its relationship with the degree of epithelial dysplasia. 61
31558280 2019
7
Actinic Cheilitis: Analysis of Clinical Subtypes, Risk Factors and Associated Signs of Actinic Damage. 61
31197386 2019
8
Use of lip photoprotection in patients suffering from actinic cheilitis. 61
31475909 2019
9
Treatments of actinic cheilitis: a systematic review of the literature. 61
31400450 2019
10
Immunoexpression of human leukocyte antigen-DR in actinic cheilitis and lower lip squamous cell carcinoma. 61
31483051 2019
11
DNA Repair Enzyme Containing Lip Balm for the Treatment of Actinic Cheilitis: A Pilot Study 61
31251551 2019
12
Surgical versus non-surgical treatment of actinic cheilitis: A systematic review and meta-analysis. 61
29908101 2019
13
Treatment of actinic cheilitis: a systematic review. 61
31011833 2019
14
Plasma cell cheilitis: the diagnosis of a disorder mimicking lip cancer. 61
30963053 2019
15
Ingenol mebutate versus imiquimod versus diclofenac for actinic cheilitis: a 6-month follow-up clinical study. 61
30242791 2019
16
Immune response and evasion mechanisms in lip carcinogenesis: An immunohistochemical study. 61
30468994 2019
17
Evidence regarding how surgical treatment of actinic cheilitis compares with nonsurgical treatment is not trustworthy and does not consider all important outcomes. 61
30119827 2019
18
Daylight photodynamic therapy for the treatment of actinic cheilitis. 61
30066408 2019
19
Actinic cheilitis and lip squamous cell carcinoma: Literature review and new data from Brazil. 61
30697396 2019
20
Actinic Cheilitis Prevalence and Risk Factors: A Cross-sectional, Multicentre Study in a Population Aged 45 Years and Over in North-west Spain. 61
30085328 2018
21
Malignant transformation of actinic cheilitis: A systematic review of observational studies. 61
29863311 2018
22
Expression of stem cell markers Nanog and Nestin in lip squamous cell carcinoma and actinic cheilitis. 61
29761881 2018
23
Daylight Photodynamic Therapy for Actinic Keratoses. 61
29752702 2018
24
Immunoexpression of glucocorticoid receptor alpha (GRα) isoform and apoptotic proteins (Bcl-2 and Bax) in actinic cheilitis and lower lip squamous cell carcinoma. 61
29935090 2018
25
Telediagnosis of oral lesions in primary care: The EstomatoNet Program. 61
29505701 2018
26
Prevalence of oral potentially malignant disorders: A systematic review and meta-analysis. 61
29738071 2018
27
Association between oral mucosal lesions and crack and cocaine addiction in men: a cross-sectional study. 61
29736657 2018
28
Dermoscopy and reflectance confocal microscopy for monitoring the treatment of actinic cheilitis with ingenol mebutate gel: Report of three cases. 61
29687567 2018
29
Expression of cancer stem cell markers CD44, ALDH1 and p75NTR in actinic cheilitis and lip cancer. 61
29779037 2018
30
Evaluation of specific modified histones in lip carcinogenesis. 61
29699903 2018
31
Differential Diagnosis of Cheilitis - How to Classify Cheilitis? 61
30431729 2018
32
Non-invasive imaging of actinic cheilitis and squamous cell carcinoma of the lip. 61
29725529 2018
33
Evaluation of epithelial dysplasia adjacent to lip squamous cell carcinoma indicates that the degree of dysplasia is not associated with the occurrence of invasive carcinoma in this site. 61
29740875 2018
34
Evaluation of Cellular Proliferative Activity in Patients with Actinic Cheilitis through Silver-stained Nucleolar Organizer Region Method. 61
29728540 2018
35
Diclofenac sodium gel therapy as an alternative to actinic cheilitis. 61
28986686 2018
36
Expression of E-cadherin, syndecan 1, Ki-67, and maintenance minichromosome 3 in tissue lesions of actinic prurigo obtained by incisional biopsy. 61
29676362 2018
37
Herpes simplex reactivation after photodynamic therapy for actinic cheilitis in a patient with Non-Hodgkin Lymphoma: a possible indication for prophylaxis. 61
29512976 2018
38
Prevalence of and Factors Associated with Actinic Cheilitis in Extractive Mining Workers. 61
29898071 2018
39
Erratum: Time-resolved fluorescence spectroscopy for clinical diagnosis of actinic cheilitis: erratum. 61
29552401 2018
40
Neglected Under Lip Cancer. 61
29483993 2018
41
The ultrastructural features of the premalignant oral lesions. 61
29940634 2018
42
5-aminolaevulinic acid patch-photodynamic therapy in the treatment of actinic cheilitis. 61
28703320 2017
43
A Diagnostic Approach to Recurrent Orofacial Swelling: A Retrospective Study of 104 Patients. 61
28601424 2017
44
Severely Crusted Cheilitis as an Initial Presentation of Systemic Lupus Erythematosus. 61
28794568 2017
45
Immunoexpression of HDAC1, HDAC2, and HAT1 in actinic cheilitis and lip squamous cell carcinoma. 61
28107582 2017
46
Oral Thrombus: Report of 122 cases with clinically descriptive data. 61
28390126 2017
47
Thioredoxin and metallothionein: Homeostasis-related proteins in lip carcinogenesis. 61
28183007 2017
48
Histopathologic features in actinic cheilitis by the comparison of grading dysplasia systems. 61
27759902 2017
49
Actinic cheilosis: early intervention prevents malignant transformation. 61
28320702 2017
50
Management of actinic cheilitis using ingenol mebutate gel: A report of seven cases. 61
27241280 2017

Variations for Actinic Cheilitis

Cosmic variations for Actinic Cheilitis:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM122734401 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.448C>T p.R150W 17:7673776-7673776 0

Expression for Actinic Cheilitis

Search GEO for disease gene expression data for Actinic Cheilitis.

Pathways for Actinic Cheilitis

Pathways related to Actinic Cheilitis according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.81 TP53 MDM2 CDKN1A BCL2
2
Show member pathways
12.8 TP53 MSH2 MDM2 CDKN1A
3
Show member pathways
12.76 TP53 MDM2 CDKN1A BCL2
4
Show member pathways
12.67 TP53 MDM2 CDKN1A BCL2
5
Show member pathways
12.66 TP53 MDM2 CDKN1A BCL2
6
Show member pathways
12.65 TP53 MSH2 MDM2 CDKN1A BCL2
7 12.62 TP53 MSH2 MDM2 CDKN1A BCL2
8
Show member pathways
12.55 TP53 MDM2 CDKN1A
9
Show member pathways
12.53 TP53 MDM2 CDKN1A BCL2
10
Show member pathways
12.47 TP53 MDM2 CDKN1A
11
Show member pathways
12.47 TP53 MDM2 CDKN1A BCL2
12
Show member pathways
12.44 TP53 MSH2 CDKN1A BCL2
13
Show member pathways
12.41 TP53 MDM2 CDKN1A
14
Show member pathways
12.41 TP53 MSH2 MDM2 CDKN1A BCL2 APEX1
15 12.38 TP53 MDM2 CDKN1A BCL2
16
Show member pathways
12.3 TP53 MDM2 BCL2
17 12.27 TP53 MSH2 MDM2 CDKN1A APEX1
18
Show member pathways
12.26 TP53 MDM2 CDKN1A
19 12.24 TP53 MDM2 BCL2
20 12.23 TP53 MDM2 CDKN1A
21
Show member pathways
12.23 TP53 MDM2 CDKN1A BCL2
22 12.17 TP53 MDM2 CDKN1A
23 12.16 TP53 MDM2 CDKN1A
24 12.13 TP53 MDM2 CDKN1A
25
Show member pathways
12.1 TP53 MDM2 CDKN1A BCL2
26 12.07 TP53 MSH2 CDKN1A
27
Show member pathways
12.07 TP53 MDM2 CDKN1A BCL2
28 12.05 TP53 MDM2 CDKN1A
29 11.97 TP53 MSH2 MDM2 BCL2
30 11.88 TP53 CDKN1A BCL2
31 11.87 TP53 MDM2 CDKN1A
32 11.82 TP53 MDM2 CDKN1A BCL2
33 11.78 TP53 CDKN1A BCL2
34 11.78 TP53 MSH2 MDM2 CDKN1A BCL2
35 11.76 TP53 MDM2 CDKN1A BCL2
36 11.75 TP53 MDM2 CDKN1A
37
Show member pathways
11.74 TP53 MDM2 CDKN1A
38 11.71 TP53 MDM2 CDKN1A
39 11.64 TP53 MDM2 CDKN1A
40 11.51 CDKN1A BCL2
41 11.5 TP53 MDM2
42 11.5 TP53 MDM2 CDKN1A BCL2 APEX1
43 11.48 TP53 MDM2 APEX1
44 11.47 MDM2 CDKN1A
45
Show member pathways
11.46 TP53 MDM2
46 11.45 TP53 MDM2
47 11.45 TP53 CDKN1A BCL2
48 11.43 TP53 CDKN1A
49 11.41 TP53 CDKN1A
50 11.37 TP53 MDM2 CDKN1A

GO Terms for Actinic Cheilitis

Cellular components related to Actinic Cheilitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleolus GO:0005730 9.46 TP53 MDM2 CDKN1A APEX1
2 nuclear body GO:0016604 9.43 TP53 MDM2 CDKN1A
3 nucleoplasm GO:0005654 9.43 TP53 MSH2 MDM2 CDKN1A BCL2 APEX1
4 protein-containing complex GO:0032991 8.92 TP53 MDM2 CDKN1A BCL2

Biological processes related to Actinic Cheilitis according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.9 TP53 CDKN1A BCL2
2 negative regulation of apoptotic process GO:0043066 9.88 TP53 MDM2 CDKN1A BCL2
3 cytokine-mediated signaling pathway GO:0019221 9.87 TP53 CDKN1A BCL2
4 regulation of apoptotic process GO:0042981 9.86 TP53 BCL2 APEX1
5 negative regulation of gene expression GO:0010629 9.86 TP53 MDM2 CDKN1A
6 heart development GO:0007507 9.83 TP53 MDM2 CDKN1A
7 regulation of cell cycle GO:0051726 9.77 TP53 CDKN1A BCL2
8 cell cycle arrest GO:0007050 9.74 TP53 MSH2 CDKN1A
9 response to glucocorticoid GO:0051384 9.72 CDKN1A BCL2
10 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 9.72 CDKN1A BCL2
11 response to ischemia GO:0002931 9.72 TP53 BCL2
12 response to UV GO:0009411 9.72 TP53 CDKN1A
13 cellular response to hypoxia GO:0071456 9.72 TP53 MDM2 BCL2
14 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.71 MSH2 BCL2
15 neuron apoptotic process GO:0051402 9.71 TP53 BCL2
16 positive regulation of B cell proliferation GO:0030890 9.71 CDKN1A BCL2
17 positive regulation of intrinsic apoptotic signaling pathway GO:2001244 9.71 TP53 BCL2
18 cellular response to glucose starvation GO:0042149 9.71 TP53 BCL2
19 negative regulation of cell growth GO:0030308 9.71 TP53 CDKN1A BCL2
20 negative regulation of mitotic cell cycle GO:0045930 9.7 TP53 BCL2
21 base-excision repair GO:0006284 9.7 TP53 APEX1
22 cellular response to organic substance GO:0071310 9.7 MDM2 BCL2
23 response to toxic substance GO:0009636 9.7 MDM2 CDKN1A BCL2
24 cellular response to ionizing radiation GO:0071479 9.69 TP53 CDKN1A
25 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 9.69 TP53 BCL2
26 response to organonitrogen compound GO:0010243 9.69 CDKN1A APEX1
27 response to steroid hormone GO:0048545 9.68 MDM2 BCL2
28 intrinsic apoptotic signaling pathway GO:0097193 9.68 TP53 CDKN1A
29 T cell differentiation in thymus GO:0033077 9.67 TP53 BCL2
30 positive regulation of reactive oxygen species metabolic process GO:2000379 9.67 TP53 CDKN1A
31 response to antibiotic GO:0046677 9.67 TP53 MDM2
32 cell aging GO:0007569 9.66 TP53 BCL2
33 response to gamma radiation GO:0010332 9.65 TP53 BCL2
34 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.65 TP53 BCL2
35 negative regulation of reactive oxygen species metabolic process GO:2000378 9.65 TP53 BCL2
36 cellular response to DNA damage stimulus GO:0006974 9.65 TP53 MSH2 CDKN1A BCL2 APEX1
37 release of cytochrome c from mitochondria GO:0001836 9.64 TP53 BCL2
38 cellular response to peptide hormone stimulus GO:0071375 9.64 MDM2 APEX1
39 positive regulation of protein export from nucleus GO:0046827 9.63 TP53 MDM2
40 response to iron ion GO:0010039 9.63 MDM2 BCL2
41 determination of adult lifespan GO:0008340 9.62 TP53 MSH2
42 mitotic cell cycle arrest GO:0071850 9.62 TP53 CDKN1A
43 response to hyperoxia GO:0055093 9.61 TP53 CDKN1A
44 cardiac septum morphogenesis GO:0060411 9.61 TP53 MDM2
45 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.61 TP53 MDM2 CDKN1A
46 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.6 TP53 CDKN1A
47 replicative senescence GO:0090399 9.58 TP53 CDKN1A
48 regulation of mitochondrial membrane permeability GO:0046902 9.56 TP53 BCL2
49 cellular response to gamma radiation GO:0071480 9.54 TP53 MDM2 CDKN1A
50 cellular response to UV-C GO:0071494 9.51 TP53 MDM2

Molecular functions related to Actinic Cheilitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.43 TP53 MSH2 MDM2
2 p53 binding GO:0002039 9.37 TP53 MDM2
3 damaged DNA binding GO:0003684 9.32 MSH2 APEX1
4 disordered domain specific binding GO:0097718 9.16 TP53 MDM2
5 protein phosphatase 2A binding GO:0051721 8.96 TP53 BCL2
6 ubiquitin protein ligase binding GO:0031625 8.92 TP53 MDM2 CDKN1A BCL2

Sources for Actinic Cheilitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....