MCID: ACT093
MIFTS: 43

Actinic Cheilitis

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Actinic Cheilitis

MalaCards integrated aliases for Actinic Cheilitis:

Name: Actinic Cheilitis 54 74
Actinic Cheilosis 54

Classifications:



External Ids:

UMLS 74 C0267026

Summaries for Actinic Cheilitis

MalaCards based summary : Actinic Cheilitis, also known as actinic cheilosis, is related to cheilitis and lip cancer. An important gene associated with Actinic Cheilitis is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Gene Expression and GPCR Pathway. The drugs Aminolevulinic acid and Imiquimod have been mentioned in the context of this disorder. Affiliated tissues include t cells, salivary gland and skin, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and Increased TP53 mRNA expression

Wikipedia : 77 Actinic cheilitis is cheilitis (lip inflammation) caused by long term sunlight exposure. Essentially it... more...

Related Diseases for Actinic Cheilitis

Diseases related to Actinic Cheilitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 cheilitis 31.4 MDM2 MSH2 TP53
2 lip cancer 29.7 CDKN1A MDM2 MSH2 TP53
3 squamous cell carcinoma 10.6
4 angular cheilitis 10.4
5 ring chromosome 7 10.2 MDM2 TP53
6 zika virus infection 10.2 MDM2 TP53
7 sclerosing liposarcoma 10.2 MDM2 TP53
8 liposarcoma 10.2 MDM2 TP53
9 sapho syndrome 10.2 MDM2 TP53
10 periosteal osteogenic sarcoma 10.2 MDM2 TP53
11 gliomatosis cerebri 10.2 MDM2 TP53
12 soft tissue sarcoma 10.2 MDM2 TP53
13 dedifferentiated liposarcoma 10.2 MDM2 TP53
14 small cell sarcoma 10.2 MDM2 TP53
15 myxosarcoma 10.2 MDM2 TP53
16 verrucous carcinoma 10.2 MDM2 TP53
17 embryonal sarcoma 10.2 MDM2 TP53
18 cardia cancer 10.2 MDM2 TP53
19 invasive bladder transitional cell carcinoma 10.2 CDKN1A TP53
20 bladder transitional cell papilloma 10.2 CDKN1A TP53
21 adult medulloblastoma 10.2 MDM2 TP53
22 atypical follicular adenoma 10.2 CDKN1A TP53
23 cellular schwannoma 10.2 MDM2 TP53
24 muscle cancer 10.2 MDM2 TP53
25 suppressor of tumorigenicity 3 10.2 CDKN1A TP53
26 giant cell glioblastoma 10.2 MDM2 TP53
27 connective tissue cancer 10.2 MDM2 TP53
28 supratentorial cancer 10.2 MDM2 TP53
29 cerebrum cancer 10.2 MDM2 TP53
30 nodular ganglioneuroblastoma 10.1 CDKN1A MDM2
31 myxoid liposarcoma 10.1 MDM2 TP53
32 grade iii astrocytoma 10.1 MDM2 TP53
33 cervical adenocarcinoma 10.1 CDKN1A TP53
34 histiocytoma 10.1 MDM2 TP53
35 cerebral primitive neuroectodermal tumor 10.1 MSH2 TP53
36 intestinal benign neoplasm 10.1 MSH2 TP53
37 inflammatory myofibroblastic tumor 10.1 MDM2 TP53
38 pleomorphic adenoma 10.1 MDM2 TP53
39 tongue cancer 10.1 CDKN1A TP53
40 familial colorectal cancer 10.0 MSH2 TP53
41 leiomyosarcoma 10.0 MDM2 TP53
42 uterine anomalies 10.0 MSH2 TP53
43 colorectal adenoma 10.0 MSH2 TP53
44 colonic disease 10.0 MSH2 TP53
45 cheilitis glandularis 10.0
46 lentigines 10.0
47 lymphoma, hodgkin, classic 10.0
48 lymphoma, non-hodgkin, familial 10.0
49 oculocutaneous albinism 10.0
50 oral squamous cell carcinoma 10.0

Graphical network of the top 20 diseases related to Actinic Cheilitis:



Diseases related to Actinic Cheilitis

Symptoms & Phenotypes for Actinic Cheilitis

GenomeRNAi Phenotypes related to Actinic Cheilitis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.02 CDKN1A HDAC1 MDM2 MSH2 TP53
2 Increased TP53 mRNA expression GR00389-S-6 8.96 HDAC1 TP53

MGI Mouse Phenotypes related to Actinic Cheilitis:

47 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10 CDKN1A HDAC1 ITGB4 MDM2 MSH2 TP53
2 immune system MP:0005387 9.95 CDKN1A HDAC1 ITGB4 MDM2 MSH2 TP53
3 cardiovascular system MP:0005385 9.93 CDKN1A HDAC1 ITGB4 MDM2 TP53
4 integument MP:0010771 9.93 CDKN1A HDAC1 ITGB4 MDM2 MSH2 TP53
5 craniofacial MP:0005382 9.91 CDKN1A HDAC1 ITGB4 MDM2 TP53
6 digestive/alimentary MP:0005381 9.89 CDKN1A ITGB4 MDM2 MSH2 TP53
7 mortality/aging MP:0010768 9.85 CDKN1A HDAC1 ITGB4 MDM2 MSH2 TP53
8 limbs/digits/tail MP:0005371 9.73 CDKN1A HDAC1 MDM2 TP53
9 neoplasm MP:0002006 9.72 CDKN1A HDAC1 MDM2 MSH2 TP53
10 liver/biliary system MP:0005370 9.71 CDKN1A HDAC1 MDM2 TP53
11 no phenotypic analysis MP:0003012 9.56 CDKN1A HDAC1 MDM2 TP53
12 pigmentation MP:0001186 9.33 HDAC1 MDM2 TP53
13 renal/urinary system MP:0005367 9.26 CDKN1A ITGB4 MDM2 TP53
14 respiratory system MP:0005388 8.92 CDKN1A HDAC1 ITGB4 TP53

Drugs & Therapeutics for Actinic Cheilitis

Drugs for Actinic Cheilitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aminolevulinic acid Approved Phase 4,Phase 1 106-60-5 137
2
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
3 Dermatologic Agents Phase 4,Phase 1
4 Photosensitizing Agents Phase 4,Phase 1
5 Adjuvants, Immunologic Phase 4
6 Immunologic Factors Phase 4
7 interferons Phase 4
8 Methyl 5-aminolevulinate Phase 4,Phase 1
9 Interferon Inducers Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Photodynamic Therapy (PDT) With Levulan and Blue Light for the Treatment of Actinic Cheilitis Completed NCT02409732 Phase 4 aminolevulinic acid hydrochloride
2 Treatment Study for Actinic Cheilitis Comparing Imiquimod 5% and Photodynamic Therapy Completed NCT00849992 Phase 4 Imiquimod 5%
3 Photodynamic Therapy to Treat Actinic Damage in Patients With Squamous Cell Carcinoma (SCC) of the Lip Completed NCT00868088 Phase 4
4 Evaluation of Ingenol Mebutate for Actinic Cheilitis Treatment Not yet recruiting NCT03452566 Phase 1, Phase 2 Ingenol mebutate gel
5 Study of Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Laser in Actinic Cheilitis Completed NCT02198469 Phase 1 Er:YAG AFL-PDT;MAL-PDT
6 Actinic Cheilitis Pre-Treated With DNA Repair Enzyme Cream Withdrawn NCT03224715 Not Applicable

Search NIH Clinical Center for Actinic Cheilitis

Genetic Tests for Actinic Cheilitis

Anatomical Context for Actinic Cheilitis

MalaCards organs/tissues related to Actinic Cheilitis:

42
T Cells, Salivary Gland, Skin, Brain, Colon, Bone, Breast

Publications for Actinic Cheilitis

Articles related to Actinic Cheilitis:

(show top 50) (show all 163)
# Title Authors Year
1
Daylight photodynamic therapy for the treatment of actinic cheilitis. ( 30066408 )
2019
2
Proper management of suspicious actinic cheilitis. ( 31032237 )
2019
3
Treatment of actinic cheilitis: a systematic review. ( 31011833 )
2019
4
Actinic cheilitis and lip squamous cell carcinoma: Literature review and new data from Brazil. ( 30697396 )
2019
5
Fludroxycortide cream as an alternative therapy for actinic cheilitis. ( 30673866 )
2019
6
Ingenol mebutate versus imiquimod versus diclofenac for actinic cheilitis: a 6-month follow-up clinical study. ( 30242791 )
2019
7
Evidence regarding how surgical treatment of actinic cheilitis compares with nonsurgical treatment is not trustworthy and does not consider all important outcomes. ( 30119827 )
2019
8
Diclofenac sodium gel therapy as an alternative to actinic cheilitis. ( 28986686 )
2018
9
Herpes simplex reactivation after photodynamic therapy for actinic cheilitis in a patient with Non-Hodgkin Lymphoma: a possible indication for prophylaxis. ( 29512976 )
2018
10
Erratum: Time-resolved fluorescence spectroscopy for clinical diagnosis of actinic cheilitis: erratum. ( 29552401 )
2018
11
Dermoscopy and reflectance confocal microscopy for monitoring the treatment of actinic cheilitis with ingenol mebutate gel: Report of three cases. ( 29687567 )
2018
12
Non-invasive imaging of actinic cheilitis and squamous cell carcinoma of the lip. ( 29725529 )
2018
13
Evaluation of Cellular Proliferative Activity in Patients with Actinic Cheilitis through Silver-stained Nucleolar Organizer Region Method. ( 29728540 )
2018
14
Expression of stem cell markers Nanog and Nestin in lip squamous cell carcinoma and actinic cheilitis. ( 29761881 )
2018
15
Expression of cancer stem cell markers CD44, ALDH1 and p75NTR in actinic cheilitis and lip cancer. ( 29779037 )
2018
16
Malignant transformation of actinic cheilitis: A systematic review of observational studies. ( 29863311 )
2018
17
Prevalence of and Factors Associated with Actinic Cheilitis in Extractive Mining Workers. ( 29898071 )
2018
18
Surgical versus non-surgical treatment of actinic cheilitis: A systematic review and meta-analysis. ( 29908101 )
2018
19
Immunoexpression of glucocorticoid receptor alpha (GRα) isoform and apoptotic proteins (Bcl-2 and Bax) in actinic cheilitis and lower lip squamous cell carcinoma. ( 29935090 )
2018
20
Actinic Cheilitis Prevalence and Risk Factors: A Cross-sectional, Multicentre Study in a Population Aged 45 Years and Over in North-west Spain. ( 30085328 )
2018
21
Management of actinic cheilitis using ingenol mebutate gel: A report of seven cases. ( 27241280 )
2017
22
Histopathologic features in actinic cheilitis by the comparison of grading dysplasia systems. ( 27759902 )
2017
23
CD8+ and FoxP3+ T-cell infiltration in actinic cheilitis. ( 27778327 )
2017
24
Evaluation of the efficacy of photodynamic therapy for the treatment of actinic cheilitis. ( 27864997 )
2017
25
Immunoexpression of HDAC1, HDAC2, and HAT1 in actinic cheilitis and lip squamous cell carcinoma. ( 28107582 )
2017
26
5-aminolaevulinic acid patch-photodynamic therapy in the treatment of actinic cheilitis. ( 28703320 )
2017
27
Actinic cheilitis: proposition and reproducibility of a clinical criterion. ( 29607086 )
2017
28
Actinic cheilosis: early intervention prevents malignant transformation. ( 28320702 )
2017
29
Loss of cytokeratin 10 indicates malignant transformation in actinic cheilitis. ( 26264639 )
2016
30
Pattern of galectins expression in actinic cheilitis with different risks of malignant transformation. ( 26711374 )
2016
31
Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer. ( 26842232 )
2016
32
A comparative study using WHO and binary oral epithelial dysplasia grading systems in actinic cheilitis. ( 27029007 )
2016
33
Immunohistochemical expression of DNA methyltransferases 1, 3a, and 3b in actinic cheilitis and lip squamous cell carcinomas. ( 27159259 )
2016
34
Evaluation of hypoxia, angiogenesis, and lymphangiogenesis in actinic cheilitis. ( 27420649 )
2016
35
Optical diagnosis of actinic cheilitis by infrared spectroscopy. ( 27491855 )
2016
36
Ingenol Mebutate for Recalcitrant Chronic Actinic Cheilitis. ( 27513668 )
2016
37
Link between immunoexpression of hMLH1 and hMSH2 proteins and clinical-epidemiological aspects of actinic cheilitis. ( 27579741 )
2016
38
Time-resolved fluorescence spectroscopy for clinical diagnosis of actinic cheilitis. ( 27867726 )
2016
39
Automated algorithm for actinic cheilitis diagnosis by wide-field fluorescence imaging. ( 27981067 )
2016
40
Efficacy of ablative fractional laser-assisted photodynamic therapy for the treatment of actinic cheilitis: 12-month follow-up results of a prospective, randomized, comparative trial. ( 25400009 )
2015
41
Ingenol mebutate gel treatment for actinic cheilitis: report of four cases. ( 25545762 )
2015
42
Photodynamic therapy for actinic cheilitis: a systematic review. ( 25627629 )
2015
43
Commentary on photodynamic therapy of actinic cheilitis. ( 25654194 )
2015
44
Value of videoroscopy in the detection of alterations of actinic cheilitis and the selection of biopsy areas. ( 25662549 )
2015
45
Ablative fractional laser assisted photodynamic therapy for the treatment of actinic cheilitis. ( 26174644 )
2015
46
Daylight photodynamic therapy with methyl-aminolevulinate for the treatment of actinic cheilitis. ( 26179312 )
2015
47
Clinicopathological profile and management of 161 cases of actinic cheilitis. ( 26375219 )
2015
48
Treatment of Actinic Cheilitis. ( 26418628 )
2015
49
Immunohistochemical expression of matrix metalloproteinase-1, matrix metalloproteinase-2 and matrix metalloproteinase-9, myofibroblasts and Ki-67 in actinic cheilitis and lip squamous cell carcinoma. ( 26515234 )
2015
50
Treatment of actinic cheilitis with methyl aminolevulinate photodynamic therapy and light fractionation: a prospective study of 10 patients. ( 26677980 )
2015

Variations for Actinic Cheilitis

Cosmic variations for Actinic Cheilitis:

9 (show top 50) (show all 1150)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM3724309 ZNF536 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.1935G>C p.Q645H 19:30445497-30445497 0
2 COSM6976115 YES1 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.1288C>T p.Q430* 18:736811-736811 0
3 COSM6914703 XPO1 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.619C>G p.Q207E 2:61498885-61498885 0
4 COSM6957917 TSC2 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.1120A>T p.T374S 16:2061871-2061871 0
5 COSM121050 TP63 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.551C>T p.S184L 3:189808498-189808498 0
6 COSM10645 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.527G>T p.C176F 17:7675085-7675085 0
7 COSM69404 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.994-1G>A p.? 17:7670716-7670716 0
8 COSM10659 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.817C>T p.R273C 17:7673803-7673803 0
9 COSM10905 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.451C>T p.P151S 17:7675161-7675161 0
10 COSM11244 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.764T>A p.I255N 17:7674199-7674199 0
11 COSM44233 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.840A>C p.R280S 17:7673780-7673780 0
12 COSM10958 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.797G>T p.G266V 17:7673823-7673823 0
13 COSM10654 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.637C>T p.R213* 17:7674894-7674894 0
14 COSM11354 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.991C>T p.Q331* 17:7673537-7673537 0
15 COSM10648 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.524G>A p.R175H 17:7675088-7675088 0
16 COSM11084 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.517G>A p.V173M 17:7675095-7675095 0
17 COSM43665 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.746G>C p.R249T 17:7674217-7674217 0
18 COSM44351 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.572C>T p.P191L 17:7674959-7674959 0
19 COSM10663 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.916C>T p.R306* 17:7673704-7673704 0
20 COSM10756 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.827C>T p.A276V 17:7673793-7673793 0
21 COSM45353 TP53 upper aerodigestive tract,mouth,other,actinic cheilitis c.673G>A p.V225I 17:7674290-7674290 0
22 COSM45618 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.931A>C p.N311H 17:7673597-7673597 0
23 COSM43695 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.748C>T p.P250S 17:7674215-7674215 0
24 COSM44229 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.515T>A p.V172D 17:7675097-7675097 0
25 COSM10725 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.701A>G p.Y234C 17:7674262-7674262 0
26 COSM10758 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.659A>G p.Y220C 17:7674872-7674872 0
27 COSM10771 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.749C>T p.P250L 17:7674214-7674214 0
28 COSM10939 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.832C>T p.P278S 17:7673788-7673788 0
29 COSM44633 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.583A>T p.I195F 17:7674948-7674948 0
30 COSM10704 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.844C>T p.R282W 17:7673776-7673776 0
31 COSM44935 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.724T>A p.C242S 17:7674239-7674239 0
32 COSM10646 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.725G>A p.C242Y 17:7674238-7674238 0
33 COSM43714 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.836G>A p.G279E 17:7673784-7673784 0
34 COSM44823 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.981T>G p.Y327* 17:7673547-7673547 0
35 COSM10724 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.839G>C p.R280T 17:7673781-7673781 0
36 COSM43559 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.517G>T p.V173L 17:7675095-7675095 0
37 COSM43680 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.523C>T p.R175C 17:7675089-7675089 0
38 COSM43906 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.843C>A p.D281E 17:7673777-7673777 0
39 COSM10863 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.833C>T p.P278L 17:7673787-7673787 0
40 COSM43947 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.614A>G p.Y205C 17:7674917-7674917 0
41 COSM44393 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.821T>C p.V274A 17:7673799-7673799 0
42 COSM10728 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.839G>A p.R280K 17:7673781-7673781 0
43 COSM11286 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.1015G>T p.E339* 17:7670694-7670694 0
44 COSM10660 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.818G>A p.R273H 17:7673802-7673802 0
45 COSM10867 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.797G>A p.G266E 17:7673823-7673823 0
46 COSM10886 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.310C>T p.Q104* 17:7676059-7676059 0
47 COSM44091 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.746G>A p.R249K 17:7674217-7674217 0
48 COSM44310 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.738G>A p.M246I 17:7674225-7674225 0
49 COSM45632 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.741C>A p.N247K 17:7674222-7674222 0
50 COSM44326 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.706T>C p.Y236H 17:7674257-7674257 0

Expression for Actinic Cheilitis

Search GEO for disease gene expression data for Actinic Cheilitis.

Pathways for Actinic Cheilitis

Pathways related to Actinic Cheilitis according to GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.57 CDKN1A HDAC1 MDM2 MSH2 TP53
2
Show member pathways
13.48 CDKN1A HDAC1 ITGB4 MDM2 TP53
3
Show member pathways
13.21 CDKN1A HDAC1 MDM2 TP53
4
Show member pathways
13.19 CDKN1A ITGB4 MDM2 TP53
5
Show member pathways
12.88 HDAC1 ITGB4 MDM2 TP53
6
Show member pathways
12.81 CDKN1A HDAC1 ITGB4 MDM2 TP53
7
Show member pathways
12.78 CDKN1A HDAC1 MDM2 MSH2 TP53
8
Show member pathways
12.63 CDKN1A MDM2 TP53
9
Show member pathways
12.62 CDKN1A HDAC1 MDM2 MSH2 TP53
10 12.58 CDKN1A HDAC1 MDM2 MSH2 TP53
11
Show member pathways
12.56 CDKN1A MDM2 TP53
12
Show member pathways
12.56 CDKN1A MDM2 MSH2 TP53
13
Show member pathways
12.51 CDKN1A MDM2 TP53
14
Show member pathways
12.47 CDKN1A MDM2 TP53
15
Show member pathways
12.45 CDKN1A HDAC1 MDM2 TP53
16
Show member pathways
12.44 CDKN1A MDM2 TP53
17
Show member pathways
12.43 CDKN1A MSH2 TP53
18 12.4 CDKN1A HDAC1 MDM2 TP53
19 12.38 CDKN1A MDM2 MSH2 TP53
20
Show member pathways
12.26 CDKN1A MDM2 TP53
21
Show member pathways
12.24 CDKN1A MDM2 TP53
22 12.24 CDKN1A HDAC1 MDM2 TP53
23
Show member pathways
12.22 CDKN1A HDAC1 TP53
24
Show member pathways
12.22 CDKN1A HDAC1 TP53
25 12.16 CDKN1A MDM2 TP53
26 12.16 CDKN1A HDAC1 MDM2 TP53
27 12.12 CDKN1A HDAC1 MDM2 TP53
28
Show member pathways
12.1 CDKN1A HDAC1 MDM2 TP53
29 12.08 CDKN1A MSH2 TP53
30
Show member pathways
12.08 CDKN1A ITGB4 MDM2 TP53
31 12.06 CDKN1A MDM2 TP53
32 11.99 CDKN1A ITGB4 MDM2 TP53
33 11.92 HDAC1 MDM2 MSH2 TP53
34 11.91 HDAC1 MDM2 TP53
35 11.9 CDKN1A MDM2 TP53
36 11.89 CDKN1A HDAC1 MDM2 TP53
37 11.88 CDKN1A MDM2 TP53
38 11.86 CDKN1A MDM2 TP53
39 11.79 CDKN1A HDAC1 ITGB4 TP53
40 11.78 CDKN1A HDAC1 MDM2
41
Show member pathways
11.76 CDKN1A MDM2 TP53
42 11.74 CDKN1A MDM2 MSH2 TP53
43
Show member pathways
11.73 HDAC1 MSH2 TP53
44 11.67 CDKN1A MDM2 TP53
45 11.64 CDKN1A HDAC1
46 11.62 CDKN1A ITGB4
47 11.61 CDKN1A HDAC1
48
Show member pathways
11.61 MDM2 TP53
49 11.58 CDKN1A HDAC1 ITGB4
50 11.53 CDKN1A HDAC1 MDM2

GO Terms for Actinic Cheilitis

Cellular components related to Actinic Cheilitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear body GO:0016604 9.13 CDKN1A MDM2 TP53
2 protein-containing complex GO:0032991 8.92 CDKN1A HDAC1 MDM2 TP53

Biological processes related to Actinic Cheilitis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.74 CDKN1A MSH2 TP53
2 negative regulation of apoptotic process GO:0043066 9.62 CDKN1A HDAC1 MDM2 TP53
3 Ras protein signal transduction GO:0007265 9.56 CDKN1A TP53
4 cellular response to ionizing radiation GO:0071479 9.55 CDKN1A TP53
5 intrinsic apoptotic signaling pathway GO:0097193 9.54 CDKN1A TP53
6 response to antibiotic GO:0046677 9.52 MDM2 TP53
7 positive regulation of reactive oxygen species metabolic process GO:2000379 9.51 CDKN1A TP53
8 cellular response to gamma radiation GO:0071480 9.49 MDM2 TP53
9 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.48 MSH2 TP53
10 response to X-ray GO:0010165 9.46 CDKN1A MSH2
11 positive regulation of protein export from nucleus GO:0046827 9.43 MDM2 TP53
12 cell cycle arrest GO:0007050 9.43 CDKN1A MSH2 TP53
13 determination of adult lifespan GO:0008340 9.4 MSH2 TP53
14 replicative senescence GO:0090399 9.37 CDKN1A TP53
15 signal transduction by p53 class mediator GO:0072331 9.16 CDKN1A TP53
16 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.13 CDKN1A MDM2 TP53
17 cellular response to actinomycin D GO:0072717 8.62 MDM2 TP53

Molecular functions related to Actinic Cheilitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.65 CDKN1A MSH2 TP53
2 chromatin binding GO:0003682 9.63 HDAC1 MSH2 TP53
3 ubiquitin protein ligase binding GO:0031625 9.5 CDKN1A MDM2 TP53
4 RNA polymerase II transcription factor binding GO:0001085 9.43 HDAC1 TP53
5 protein N-terminus binding GO:0047485 9.43 HDAC1 MDM2 TP53
6 promoter-specific chromatin binding GO:1990841 9.4 HDAC1 TP53
7 disordered domain specific binding GO:0097718 9.37 MDM2 TP53
8 enzyme binding GO:0019899 9.26 HDAC1 MDM2 MSH2 TP53
9 core promoter sequence-specific DNA binding GO:0001046 9.16 HDAC1 TP53
10 p53 binding GO:0002039 8.8 HDAC1 MDM2 TP53

Sources for Actinic Cheilitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
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47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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