MCID: ACT093
MIFTS: 41

Actinic Cheilitis

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Actinic Cheilitis

MalaCards integrated aliases for Actinic Cheilitis:

Name: Actinic Cheilitis 53 72
Actinic Cheilosis 53

Classifications:



External Ids:

UMLS 72 C0267026

Summaries for Actinic Cheilitis

MalaCards based summary : Actinic Cheilitis, also known as actinic cheilosis, is related to cheilitis and lymphoma, non-hodgkin, familial. An important gene associated with Actinic Cheilitis is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Akt Signaling and PI3K-Akt signaling pathway. The drugs Imiquimod and Aminolevulinic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, salivary gland and t cells, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and cellular

Wikipedia : 75 Actinic cheilitis is cheilitis (lip inflammation) caused by long term sunlight exposure. Essentially it... more...

Related Diseases for Actinic Cheilitis

Diseases related to Actinic Cheilitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 115)
# Related Disease Score Top Affiliating Genes
1 cheilitis 30.2 TP53 MSH2 MDM2 APEX1
2 lymphoma, non-hodgkin, familial 29.8 TP53 MDM2 BCL2
3 suppressor of tumorigenicity 3 29.7 TP53 CDKN1A BCL2
4 lip cancer 29.7 TP53 MSH2 MDM2 CDKN1A
5 keratosis 10.6
6 actinic keratosis 10.6
7 squamous cell carcinoma 10.6
8 zika virus infection 10.4 TP53 MDM2
9 ring chromosome 7 10.4 TP53 MDM2
10 sclerosing liposarcoma 10.4 TP53 MDM2
11 liposarcoma 10.4 TP53 MDM2
12 sapho syndrome 10.4 TP53 MDM2
13 periosteal osteogenic sarcoma 10.3 TP53 MDM2
14 dedifferentiated liposarcoma 10.3 TP53 MDM2
15 gliomatosis cerebri 10.3 TP53 MDM2
16 small cell sarcoma 10.3 TP53 MDM2
17 myxosarcoma 10.3 TP53 MDM2
18 embryonal sarcoma 10.3 TP53 MDM2
19 verrucous carcinoma 10.3 TP53 MDM2
20 cardia cancer 10.3 TP53 MDM2
21 bladder transitional cell papilloma 10.3 TP53 CDKN1A
22 invasive bladder transitional cell carcinoma 10.3 TP53 CDKN1A
23 atypical follicular adenoma 10.3 TP53 CDKN1A
24 malignant teratoma 10.3 TP53 BCL2
25 basal cell carcinoma 10.3
26 adult medulloblastoma 10.3 TP53 MDM2
27 cervical carcinosarcoma 10.3 TP53 BCL2
28 testicular torsion 10.3 TP53 BCL2
29 cellular schwannoma 10.3 TP53 MDM2
30 muscle cancer 10.3 TP53 MDM2
31 gastric lymphoma 10.3 TP53 BCL2
32 giant cell glioblastoma 10.3 TP53 MDM2
33 connective tissue cancer 10.3 TP53 MDM2
34 cerebrum cancer 10.3 TP53 MDM2
35 nodular ganglioneuroblastoma 10.2 MDM2 CDKN1A
36 supratentorial cancer 10.2 TP53 MDM2
37 hidradenocarcinoma 10.2 TP53 BCL2
38 focal cortical dysplasia, type ii 10.2 TP53 BCL2
39 keratocystic odontogenic tumor 10.2 TP53 BCL2
40 in situ carcinoma 10.2
41 myxoid liposarcoma 10.2 TP53 MDM2
42 grade iii astrocytoma 10.2 TP53 MDM2
43 histiocytoma 10.2 TP53 MDM2
44 cervical adenocarcinoma 10.2 TP53 CDKN1A
45 cerebral primitive neuroectodermal tumor 10.2 TP53 MSH2
46 neurofibromatosis, type ii 10.1
47 skin disease 10.1
48 superficial basal cell carcinoma 10.1
49 herpes simplex 10.1
50 albinism 10.1

Graphical network of the top 20 diseases related to Actinic Cheilitis:



Diseases related to Actinic Cheilitis

Symptoms & Phenotypes for Actinic Cheilitis

GenomeRNAi Phenotypes related to Actinic Cheilitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.1 APEX1 BCL2 CDKN1A MDM2 MSH2 TP53

MGI Mouse Phenotypes related to Actinic Cheilitis:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.01 APEX1 BCL2 CDKN1A MDM2 MSH2 TP53
2 cardiovascular system MP:0005385 9.95 APEX1 BCL2 CDKN1A MDM2 TP53
3 homeostasis/metabolism MP:0005376 9.93 APEX1 BCL2 CDKN1A MDM2 MSH2 TP53
4 digestive/alimentary MP:0005381 9.91 BCL2 CDKN1A MDM2 MSH2 TP53
5 immune system MP:0005387 9.91 APEX1 BCL2 CDKN1A MDM2 MSH2 TP53
6 embryo MP:0005380 9.89 APEX1 BCL2 CDKN1A MDM2 TP53
7 endocrine/exocrine gland MP:0005379 9.88 APEX1 BCL2 CDKN1A MDM2 TP53
8 craniofacial MP:0005382 9.83 BCL2 CDKN1A MDM2 TP53
9 integument MP:0010771 9.8 BCL2 CDKN1A MDM2 MSH2 TP53
10 mortality/aging MP:0010768 9.8 APEX1 BCL2 CDKN1A MDM2 MSH2 TP53
11 liver/biliary system MP:0005370 9.67 APEX1 CDKN1A MDM2 TP53
12 muscle MP:0005369 9.65 APEX1 BCL2 CDKN1A MDM2 TP53
13 neoplasm MP:0002006 9.63 APEX1 BCL2 CDKN1A MDM2 MSH2 TP53
14 renal/urinary system MP:0005367 9.26 BCL2 CDKN1A MDM2 TP53
15 reproductive system MP:0005389 9.02 APEX1 BCL2 CDKN1A MDM2 TP53

Drugs & Therapeutics for Actinic Cheilitis

DrugBank drugs 16 :

# Drug Name Indication DrugBank ID
1 Aminolevulinic acid Aminolevulinic acid plus blue light illumination using a blue light photodynamic therapy illuminator is indicated for the treatment of minimally to moderately thick actinic keratoses of the face or scalp. DB00855

Drugs for Actinic Cheilitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
2
Aminolevulinic acid Approved Phase 4 106-60-5 137
3 Adjuvants, Immunologic Phase 4
4 Methyl 5-aminolevulinate Phase 4
5 Immunologic Factors Phase 4
6 interferons Phase 4
7 Interferon Inducers Phase 4
8 Dermatologic Agents Phase 4
9 Photosensitizing Agents Phase 4
10
Lidocaine Approved, Vet_approved Phase 1 137-58-6 3676
11
Prilocaine Approved Phase 1 721-50-6 4906
12 Anesthetics, Local Phase 1
13 Sodium Channel Blockers Phase 1
14 Lidocaine, Prilocaine Drug Combination Phase 1
15 Diuretics, Potassium Sparing Phase 1
16 Peripheral Nervous System Agents Phase 1
17 Central Nervous System Depressants Phase 1
18 Anesthetics Phase 1
19 Anti-Arrhythmia Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Prospective Study Comparing 5% Imiquimod and Photodynamic Therapy for Actinic Cheilitis Completed NCT00849992 Phase 4 Imiquimod 5%
2 Photodynamic Therapy (PDT) With Levulan and Blue Light for the Treatment of Actinic Cheilitis Completed NCT02409732 Phase 4 aminolevulinic acid hydrochloride
3 A Clinical Trial of ALA Photodynamic Therapy for Treatment of Actinic Cheilitis in Patients With Squamous Cell Carcinoma of the Lip. Completed NCT00868088 Phase 4
4 Photodynamic Therapy With Metil 5-aminolevulinate for Actinic Cheilitis - A Phase 2 Randomized Double-blind Placebo Controlled Clinical Trial Not yet recruiting NCT03990636 Phase 2 Metil 5-aminolevulinate
5 Phase 1/2 Clinical Trial for the Evaluation of Ingenol Mebutate for Actinic Cheilitis Withdrawn NCT03452566 Phase 1, Phase 2 Ingenol mebutate gel
6 A Randomized, Prospective Study Comparing Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Ablative Fractional Laser Treatment for Actinic Cheilitis Completed NCT02198469 Phase 1 Er:YAG AFL-PDT;MAL-PDT
7 Efficacy of Iontophoresis-assisted Ablative Fractional Laser Photodynamic Therapy With Short Incubation Time for the Treatment of Actinic Keratosis: 12-month Follow-up Results of a Prospective, Randomised, Comparative Trial Completed NCT02670655 Phase 1 lidocaine/prilocaine (5%) application;MAL application
8 A Randomised Trial Comparing Methyl Aminolaevulinate Photodynamic Therapy With and Without Ablative Fractional Laser Treatment in Patients With Microinvasive Squamous Cell Carcinoma: Results From a 24-month Follow-up Completed NCT02666534 Phase 1 lidocaine-prilocaine 5% cream application;methyl-aminolevulinate application
9 Actinic Cheilitis Pre-Treated With DNA Repair Enzyme Cream Withdrawn NCT03224715

Search NIH Clinical Center for Actinic Cheilitis

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Aminolevulinic acid

Genetic Tests for Actinic Cheilitis

Anatomical Context for Actinic Cheilitis

MalaCards organs/tissues related to Actinic Cheilitis:

41
Skin, Salivary Gland, T Cells, Kidney, Nk Cells

Publications for Actinic Cheilitis

Articles related to Actinic Cheilitis:

(show top 50) (show all 293)
# Title Authors PMID Year
1
Proper management of suspicious actinic cheilitis. 38
31032237 2019
2
Treatments of actinic cheilitis: a systematic review of the literature. 38
31400450 2019
3
Detection of human papillomaviruses and human polyomaviruses in immunosuppressed and immunocompetent individuals with actinic cheilitis: a case series. 38
31281986 2019
4
DNA Repair Enzyme Containing Lip Balm for the Treatment of Actinic Cheilitis: A Pilot Study 38
31251551 2019
5
Actinic Cheilitis: Analysis of Clinical Subtypes, Risk Factors and Associated Signs of Actinic Damage. 38
31197386 2019
6
Surgical versus non-surgical treatment of actinic cheilitis: A systematic review and meta-analysis. 38
29908101 2019
7
Treatment of actinic cheilitis: a systematic review. 38
31011833 2019
8
Plasma cell cheilitis: the diagnosis of a disorder mimicking lip cancer. 38
30963053 2019
9
Ingenol mebutate versus imiquimod versus diclofenac for actinic cheilitis: a 6-month follow-up clinical study. 38
30242791 2019
10
Immune response and evasion mechanisms in lip carcinogenesis: An immunohistochemical study. 38
30468994 2019
11
Evidence regarding how surgical treatment of actinic cheilitis compares with nonsurgical treatment is not trustworthy and does not consider all important outcomes. 38
30119827 2019
12
Fludroxycortide cream as an alternative therapy for actinic cheilitis. 38
30673866 2019
13
Daylight photodynamic therapy for the treatment of actinic cheilitis. 38
30066408 2019
14
Actinic cheilitis and lip squamous cell carcinoma: Literature review and new data from Brazil. 38
30697396 2019
15
Malignant transformation of actinic cheilitis: A systematic review of observational studies. 38
29863311 2018
16
Actinic Cheilitis Prevalence and Risk Factors: A Cross-sectional, Multicentre Study in a Population Aged 45 Years and Over in North-west Spain. 38
30085328 2018
17
Expression of stem cell markers Nanog and Nestin in lip squamous cell carcinoma and actinic cheilitis. 38
29761881 2018
18
Daylight Photodynamic Therapy for Actinic Keratoses. 38
29752702 2018
19
Immunoexpression of glucocorticoid receptor alpha (GRα) isoform and apoptotic proteins (Bcl-2 and Bax) in actinic cheilitis and lower lip squamous cell carcinoma. 38
29935090 2018
20
Telediagnosis of oral lesions in primary care: The EstomatoNet Program. 38
29505701 2018
21
Prevalence of oral potentially malignant disorders: A systematic review and meta-analysis. 38
29738071 2018
22
Association between oral mucosal lesions and crack and cocaine addiction in men: a cross-sectional study. 38
29736657 2018
23
Dermoscopy and reflectance confocal microscopy for monitoring the treatment of actinic cheilitis with ingenol mebutate gel: Report of three cases. 38
29687567 2018
24
Expression of cancer stem cell markers CD44, ALDH1 and p75NTR in actinic cheilitis and lip cancer. 38
29779037 2018
25
Evaluation of specific modified histones in lip carcinogenesis. 38
29699903 2018
26
Differential Diagnosis of Cheilitis - How to Classify Cheilitis? 38
30431729 2018
27
Non-invasive imaging of actinic cheilitis and squamous cell carcinoma of the lip. 38
29725529 2018
28
Evaluation of epithelial dysplasia adjacent to lip squamous cell carcinoma indicates that the degree of dysplasia is not associated with the occurrence of invasive carcinoma in this site. 38
29740875 2018
29
Evaluation of Cellular Proliferative Activity in Patients with Actinic Cheilitis through Silver-stained Nucleolar Organizer Region Method. 38
29728540 2018
30
Diclofenac sodium gel therapy as an alternative to actinic cheilitis. 38
28986686 2018
31
Expression of E-cadherin, syndecan 1, Ki-67, and maintenance minichromosome 3 in tissue lesions of actinic prurigo obtained by incisional biopsy. 38
29676362 2018
32
Herpes simplex reactivation after photodynamic therapy for actinic cheilitis in a patient with Non-Hodgkin Lymphoma: a possible indication for prophylaxis. 38
29512976 2018
33
Prevalence of and Factors Associated with Actinic Cheilitis in Extractive Mining Workers. 38
29898071 2018
34
Erratum: Time-resolved fluorescence spectroscopy for clinical diagnosis of actinic cheilitis: erratum. 38
29552401 2018
35
Neglected Under Lip Cancer. 38
29483993 2018
36
The ultrastructural features of the premalignant oral lesions. 38
29940634 2018
37
5-aminolaevulinic acid patch-photodynamic therapy in the treatment of actinic cheilitis. 38
28703320 2017
38
A Diagnostic Approach to Recurrent Orofacial Swelling: A Retrospective Study of 104 Patients. 38
28601424 2017
39
Severely Crusted Cheilitis as an Initial Presentation of Systemic Lupus Erythematosus. 38
28794568 2017
40
Immunoexpression of HDAC1, HDAC2, and HAT1 in actinic cheilitis and lip squamous cell carcinoma. 38
28107582 2017
41
Oral Thrombus: Report of 122 cases with clinically descriptive data. 38
28390126 2017
42
Thioredoxin and metallothionein: Homeostasis-related proteins in lip carcinogenesis. 38
28183007 2017
43
Histopathologic features in actinic cheilitis by the comparison of grading dysplasia systems. 38
27759902 2017
44
Management of actinic cheilitis using ingenol mebutate gel: A report of seven cases. 38
27241280 2017
45
Actinic cheilosis: early intervention prevents malignant transformation. 38
28320702 2017
46
High Altitude Dermatology. 38
28216727 2017
47
Application of Theranostics in Oncology. 38
28971421 2017
48
Common malignant cutaneous conditions among albinos in Kenya. 38
28638810 2017
49
Evaluation of the efficacy of photodynamic therapy for the treatment of actinic cheilitis. 38
27864997 2017
50
Actinic cheilitis: proposition and reproducibility of a clinical criterion. 38
29607086 2017

Variations for Actinic Cheilitis

Cosmic variations for Actinic Cheilitis:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM563 NRAS upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.34G>A p.G12S 1:114716127-114716127 0

Expression for Actinic Cheilitis

Search GEO for disease gene expression data for Actinic Cheilitis.

Pathways for Actinic Cheilitis

Pathways related to Actinic Cheilitis according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.18 TP53 MDM2 CDKN1A BCL2
2
Show member pathways
12.81 TP53 MDM2 CDKN1A BCL2
3
Show member pathways
12.79 TP53 MSH2 MDM2 CDKN1A
4
Show member pathways
12.78 TP53 MDM2 CDKN1A BCL2
5
Show member pathways
12.67 TP53 MSH2 MDM2 CDKN1A BCL2
6
Show member pathways
12.66 TP53 MDM2 CDKN1A BCL2
7 12.63 TP53 MSH2 MDM2 CDKN1A BCL2
8
Show member pathways
12.57 TP53 CDKN1A BCL2
9
Show member pathways
12.54 TP53 MDM2 CDKN1A
10
Show member pathways
12.54 TP53 MDM2 CDKN1A BCL2
11
Show member pathways
12.46 TP53 MDM2 CDKN1A
12
Show member pathways
12.44 TP53 MDM2 CDKN1A
13
Show member pathways
12.44 TP53 MSH2 CDKN1A BCL2
14
Show member pathways
12.41 TP53 MDM2 CDKN1A
15
Show member pathways
12.41 TP53 MSH2 MDM2 CDKN1A BCL2 APEX1
16 12.4 TP53 MDM2 CDKN1A BCL2
17 12.3 TP53 MSH2 MDM2 CDKN1A APEX1
18
Show member pathways
12.29 TP53 MDM2 BCL2
19
Show member pathways
12.25 TP53 MDM2 CDKN1A
20
Show member pathways
12.25 TP53 MDM2 CDKN1A BCL2
21 12.23 TP53 MDM2 CDKN1A
22 12.16 TP53 MDM2 CDKN1A
23 12.16 TP53 MDM2 CDKN1A
24 12.12 TP53 MDM2 CDKN1A
25
Show member pathways
12.11 TP53 MDM2 CDKN1A BCL2
26
Show member pathways
12.08 TP53 MDM2 CDKN1A BCL2
27 12.06 TP53 MSH2 CDKN1A
28 12.04 TP53 MDM2 CDKN1A
29 12 TP53 MDM2 CDKN1A BCL2
30 11.98 TP53 MSH2 MDM2 BCL2
31 11.88 TP53 CDKN1A BCL2
32 11.86 TP53 MDM2 CDKN1A
33 11.85 TP53 MDM2 CDKN1A BCL2 APEX1
34 11.84 TP53 MDM2 CDKN1A BCL2
35 11.78 TP53 CDKN1A BCL2
36 11.78 TP53 MDM2 CDKN1A BCL2
37 11.78 TP53 MSH2 MDM2 CDKN1A BCL2
38 11.75 TP53 MDM2 CDKN1A
39
Show member pathways
11.74 TP53 MDM2 CDKN1A
40 11.71 TP53 MDM2 CDKN1A
41 11.66 TP53 MDM2 CDKN1A
42
Show member pathways
11.6 TP53 MDM2
43 11.53 TP53 MDM2 CDKN1A BCL2 APEX1
44 11.51 CDKN1A BCL2
45 11.51 TP53 MDM2 APEX1
46 11.5 TP53 MDM2
47 11.47 MDM2 CDKN1A
48 11.47 TP53 CDKN1A BCL2
49
Show member pathways
11.45 TP53 MDM2
50 11.45 TP53 MDM2

GO Terms for Actinic Cheilitis

Cellular components related to Actinic Cheilitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleolus GO:0005730 9.56 TP53 MDM2 CDKN1A APEX1
2 nuclear body GO:0016604 9.33 TP53 MDM2 CDKN1A
3 protein-containing complex GO:0032991 9.26 TP53 MDM2 CDKN1A BCL2
4 nucleoplasm GO:0005654 9.1 TP53 MSH2 MDM2 CDKN1A BCL2 APEX1

Biological processes related to Actinic Cheilitis according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.85 TP53 CDKN1A BCL2
2 cytokine-mediated signaling pathway GO:0019221 9.83 TP53 CDKN1A BCL2
3 regulation of apoptotic process GO:0042981 9.81 TP53 BCL2 APEX1
4 negative regulation of apoptotic process GO:0043066 9.81 TP53 MDM2 CDKN1A BCL2
5 B cell differentiation GO:0030183 9.69 MSH2 BCL2
6 Ras protein signal transduction GO:0007265 9.68 TP53 CDKN1A
7 response to glucocorticoid GO:0051384 9.68 CDKN1A BCL2
8 cellular response to hydrogen peroxide GO:0070301 9.68 MDM2 APEX1
9 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 9.67 CDKN1A BCL2
10 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.67 MSH2 BCL2
11 cellular response to organic substance GO:0071310 9.67 MDM2 BCL2
12 cell cycle arrest GO:0007050 9.67 TP53 MSH2 CDKN1A
13 cellular response to glucose starvation GO:0042149 9.66 TP53 BCL2
14 base-excision repair GO:0006284 9.66 TP53 APEX1
15 response to organonitrogen compound GO:0010243 9.65 CDKN1A APEX1
16 positive regulation of intrinsic apoptotic signaling pathway GO:2001244 9.65 TP53 BCL2
17 cellular response to ionizing radiation GO:0071479 9.64 TP53 CDKN1A
18 response to steroid hormone GO:0048545 9.63 MDM2 BCL2
19 response to antibiotic GO:0046677 9.63 TP53 MDM2
20 intrinsic apoptotic signaling pathway GO:0097193 9.62 TP53 CDKN1A
21 response to gamma radiation GO:0010332 9.62 TP53 BCL2
22 positive regulation of reactive oxygen species metabolic process GO:2000379 9.61 TP53 CDKN1A
23 cellular response to gamma radiation GO:0071480 9.61 TP53 MDM2
24 cellular response to hypoxia GO:0071456 9.61 TP53 MDM2 BCL2
25 cell aging GO:0007569 9.6 TP53 BCL2
26 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.59 TP53 MSH2
27 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.58 TP53 BCL2
28 response to X-ray GO:0010165 9.58 MSH2 CDKN1A
29 negative regulation of cell growth GO:0030308 9.58 TP53 CDKN1A BCL2
30 positive regulation of protein export from nucleus GO:0046827 9.57 TP53 MDM2
31 cellular response to peptide hormone stimulus GO:0071375 9.56 MDM2 APEX1
32 response to drug GO:0042493 9.56 MDM2 CDKN1A BCL2 APEX1
33 response to iron ion GO:0010039 9.55 MDM2 BCL2
34 determination of adult lifespan GO:0008340 9.54 TP53 MSH2
35 response to toxic substance GO:0009636 9.54 MDM2 CDKN1A BCL2
36 replicative senescence GO:0090399 9.52 TP53 CDKN1A
37 response to UV-B GO:0010224 9.48 MSH2 BCL2
38 regulation of mitochondrial membrane permeability GO:0046902 9.46 TP53 BCL2
39 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.33 TP53 MDM2 CDKN1A
40 signal transduction by p53 class mediator GO:0072331 9.32 TP53 CDKN1A
41 cellular response to DNA damage stimulus GO:0006974 9.02 TP53 MSH2 CDKN1A BCL2 APEX1
42 cellular response to actinomycin D GO:0072717 8.96 TP53 MDM2

Molecular functions related to Actinic Cheilitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.58 TP53 MSH2 CDKN1A
2 enzyme binding GO:0019899 9.43 TP53 MSH2 MDM2
3 damaged DNA binding GO:0003684 9.37 MSH2 APEX1
4 p53 binding GO:0002039 9.32 TP53 MDM2
5 disordered domain specific binding GO:0097718 9.16 TP53 MDM2
6 protein phosphatase 2A binding GO:0051721 8.96 TP53 BCL2
7 ubiquitin protein ligase binding GO:0031625 8.92 TP53 MDM2 CDKN1A BCL2

Sources for Actinic Cheilitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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