MCID: ACT093
MIFTS: 37

Actinic Cheilitis

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Actinic Cheilitis

MalaCards integrated aliases for Actinic Cheilitis:

Name: Actinic Cheilitis 20 70
Actinic Cheilosis 20

Classifications:



External Ids:

UMLS 70 C0267026

Summaries for Actinic Cheilitis

MalaCards based summary : Actinic Cheilitis, also known as actinic cheilosis, is related to suppressor of tumorigenicity 3 and oral cancer. An important gene associated with Actinic Cheilitis is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Akt Signaling and PI3K/AKT activation. The drugs Methyl 5-aminolevulinate and Imiquimod have been mentioned in the context of this disorder. Affiliated tissues include skin, nk cells and t cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 73 Actinic cheilitis is cheilitis (lip inflammation) caused by long term sunlight exposure. Essentially it... more...

Related Diseases for Actinic Cheilitis

Diseases related to Actinic Cheilitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
# Related Disease Score Top Affiliating Genes
1 suppressor of tumorigenicity 3 30.2 TP53 CDKN1A
2 oral cancer 30.1 TP53 MDM2 CDKN1A
3 cheilitis 30.0 TP53 MSH2 MDM2 FGFR3 CDKN1A APEX1
4 lip cancer 29.9 TP53 MSH2 MDM2 CDKN1A
5 basal cell carcinoma 29.6 TP53 MSH2 MDM2 CDKN1A
6 skin carcinoma 29.1 TP53 MSH2 MDM2 CDKN1A
7 lymphoma, non-hodgkin, familial 28.9 TP53 MSH2 MDM2
8 keratosis 10.7
9 actinic keratosis 10.6
10 squamous cell carcinoma 10.6
11 in situ carcinoma 10.2
12 ring chromosome 7 10.2 TP53 MDM2
13 ring chromosome 10.2 TP53 MDM2
14 esophagus verrucous carcinoma 10.2 TP53 MDM2
15 verrucous carcinoma 10.2 TP53 MDM2
16 undifferentiated embryonal sarcoma of the liver 10.2 TP53 MDM2
17 embryonal sarcoma 10.2 TP53 MDM2
18 pediatric liposarcoma 10.2 TP53 MDM2
19 periosteal osteogenic sarcoma 10.2 TP53 MDM2
20 maxillary sinus adenocarcinoma 10.2 TP53 MDM2
21 peripheral osteosarcoma 10.2 TP53 MDM2
22 soft tissue sarcoma 10.2 TP53 MDM2
23 parameningeal embryonal rhabdomyosarcoma 10.2 TP53 MDM2
24 embryonal rhabdomyosarcoma 10.2 TP53 MDM2
25 cheilitis glandularis 10.2
26 angular cheilitis 10.2
27 skin disease 10.2
28 superficial basal cell carcinoma 10.2
29 acne 10.2
30 herpes simplex 10.2
31 albinism 10.2
32 leukoplakia 10.2
33 discoid lupus erythematosus 10.2
34 conventional fibrosarcoma 10.1 TP53 MDM2
35 adult astrocytic tumour 10.1 TP53 MDM2
36 malignant spiradenoma 10.1 TP53 MDM2
37 familial retinoblastoma 10.1 TP53 MDM2
38 anal squamous cell carcinoma 10.1 TP53 MDM2
39 sapho syndrome 10.1 TP53 MDM2
40 human papillomavirus infectious disease 10.1 TP53 CDKN1A
41 sarcomatoid renal cell carcinoma 10.1 TP53 MDM2
42 gliomatosis cerebri 10.1 TP53 MDM2
43 invasive bladder transitional cell carcinoma 10.1 TP53 CDKN1A
44 cardia cancer 10.1 TP53 MDM2
45 connective tissue benign neoplasm 10.1 TP53 MDM2
46 skin papilloma 10.1 TP53 CDKN1A
47 acanthoma 10.1 TP53 FGFR3
48 cataract 10.1
49 premature aging 10.1
50 non-invasive bladder papillary urothelial neoplasm 10.1 TP53 FGFR3

Graphical network of the top 20 diseases related to Actinic Cheilitis:



Diseases related to Actinic Cheilitis

Symptoms & Phenotypes for Actinic Cheilitis

GenomeRNAi Phenotypes related to Actinic Cheilitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.17 CDKN1A
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.17 CDKN1A TP53
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.17 CDKN1A MDM2 MSH2 TP53

MGI Mouse Phenotypes related to Actinic Cheilitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.91 APEX1 CDKN1A FGFR3 MDM2 MSH2 TP53
2 immune system MP:0005387 9.85 APEX1 CDKN1A FGFR3 MDM2 MSH2 TP53
3 digestive/alimentary MP:0005381 9.8 CDKN1A FGFR3 MDM2 MSH2 TP53
4 integument MP:0010771 9.72 CDKN1A FGFR3 MDM2 MSH2 TP53
5 neoplasm MP:0002006 9.63 APEX1 CDKN1A FGFR3 MDM2 MSH2 TP53
6 limbs/digits/tail MP:0005371 9.56 CDKN1A FGFR3 MDM2 TP53
7 no phenotypic analysis MP:0003012 9.26 CDKN1A FGFR3 MDM2 TP53
8 reproductive system MP:0005389 9.02 APEX1 CDKN1A FGFR3 MDM2 TP53

Drugs & Therapeutics for Actinic Cheilitis

Drugs for Actinic Cheilitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Methyl 5-aminolevulinate Phase 4
2
Imiquimod Approved, Investigational Phase 2, Phase 3 99011-02-6 57469
3
Chitosan Experimental Phase 2, Phase 3 9012-76-4 71853
4 Dermatologic Agents Phase 2, Phase 3
5 Immunologic Factors Phase 2, Phase 3
6 Adjuvants, Immunologic Phase 2, Phase 3
7 interferons Phase 2, Phase 3
8 Protective Agents Phase 2, Phase 3
9 Radiation-Protective Agents Phase 2, Phase 3
10 Sunscreening Agents Phase 2, Phase 3
11
Aminolevulinic acid Approved Phase 2 106-60-5 137
12 Photosensitizing Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Photodynamic Therapy (PDT) With Levulan and Blue Light for the Treatment of Actinic Cheilitis Completed NCT02409732 Phase 4 aminolevulinic acid hydrochloride
2 Randomized Prospective Study Comparing 5% Imiquimod and Photodynamic Therapy for Actinic Cheilitis Completed NCT00849992 Phase 4 Imiquimod 5%
3 A Clinical Trial of ALA Photodynamic Therapy for Treatment of Actinic Cheilitis in Patients With Squamous Cell Carcinoma of the Lip. Completed NCT00868088 Phase 4
4 Trichloroacetic Acid as a Topical Treatment for Actinic Cheilitis Not yet recruiting NCT04744103 Phase 4 TCA
5 Evaluation of Topical Application of 5% Imiquimod, 0.05% Imiquimod and 0.05% Nanoencapsulated Imiquimod Gel in the Treatment of Actinic Cheilitis: a Randomized Controlled Trial Recruiting NCT04219358 Phase 2, Phase 3 Vehicle Gel Base;Imiquimod 5% gel;Imiquimod 0,05% gel;Imiquimod nanoencapsulated 0,05% gel;Lip sunscreen 30 Sun Protector Factor (SPF);Dexpanthenol
6 Photodynamic Therapy With Metil 5-aminolevulinate for Actinic Cheilitis - A Phase 2 Randomized Double-blind Placebo Controlled Clinical Trial Not yet recruiting NCT03990636 Phase 2 Metil 5-aminolevulinate
7 Phase 1/2 Clinical Trial for the Evaluation of Ingenol Mebutate for Actinic Cheilitis Withdrawn NCT03452566 Phase 1, Phase 2 Ingenol mebutate gel
8 A Randomized, Prospective Study Comparing Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Ablative Fractional Laser Treatment for Actinic Cheilitis Completed NCT02198469 Phase 1 Er:YAG AFL-PDT;MAL-PDT
9 Actinic Cheilitis Pre-Treated With DNA Repair Enzyme Cream Withdrawn NCT03224715

Search NIH Clinical Center for Actinic Cheilitis

Genetic Tests for Actinic Cheilitis

Anatomical Context for Actinic Cheilitis

MalaCards organs/tissues related to Actinic Cheilitis:

40
Skin, Nk Cells, T Cells

Publications for Actinic Cheilitis

Articles related to Actinic Cheilitis:

(show top 50) (show all 328)
# Title Authors PMID Year
1
Actinic cheilitis: a systematic review of treatment options. 61
33251620 2021
2
Sun protection as a protective factor for actinic cheilitis: cross-sectional population-based study. 61
33751725 2021
3
Use of topical anti-inflammatory and antineoplastic agents in the treatment of young-aged actinic cheilitis: A systematic review. 61
33786961 2021
4
Co-existence of cheilitis glandularis and actinic cheilitis-an update. 61
32740769 2021
5
Actinic cheilitis or discoid lupus erythematosus? 61
33625556 2021
6
Actinic cheilitis may resemble oral lichenoid-type lesions or discoid lupus erythematosus. 61
33625557 2021
7
Vermilionectomy followed by reconstruction of the vermilion mucosa using allograft dermal matrix in patients with actinic cheilitis of the lower lip. 61
32396694 2021
8
The relevance of miRNAs as promising biomarkers in lip cancer. 61
33439343 2021
9
Presence of Incipient Fungal Infection in Atypical Squamous Lesions of the Lip. 61
33481375 2021
10
Epithelial Dysplasia in Actinic Cheilitis: Microscopic Study of 70 Cases from Brazil. 61
33372240 2020
11
Daylight photodynamic therapy for the management of actinic cheilitis. 61
32266532 2020
12
Actinic Cheilitis Treated With Daylight Photodynamic Therapy. 61
32619419 2020
13
Demographic and Clinicopathologic Features of Actinic Cheilitis and Lip Squamous Cell Carcinoma: a Brazilian Multicentre Study. 61
32077056 2020
14
Therapeutic approaches for actinic cheilitis: therapeutic efficacy and malignant transformation after treatment. 61
32171621 2020
15
Evaluation of effect of a vitamin-based barrier cream on the clinical severity of actinic cheilitis: A preliminary study. 61
33154796 2020
16
5-Aminolaevulinic acid patch photodynamic therapy for the treatment of actinic keratoses: preliminary results from an Italian study in the real-life setting. 61
33026214 2020
17
Immunohistochemical analysis of epithelium adjacent to lip cancer: A meta-analysis. 61
32945581 2020
18
Dermatological and epidemiological profile of patients with albinism in Togo in 2019: results of two consultation campaigns. 61
32720350 2020
19
Treatments of actinic cheilitis: A systematic review of the literature. 61
31400450 2020
20
PI3K/AKT/mTOR pathway activation in actinic cheilitis and lip squamous cell carcinomas. 61
32255224 2020
21
5-Aminolevulinic acid patch (Alacare) photodynamic therapy for actinic cheilitis: data from a prospective 12-month follow-up study on 21 patients. 61
31999856 2020
22
Social and behavioural associated factors of actinic cheilitis in rural workers. 61
32790925 2020
23
Histopathological features of photodamage and mast cell infiltrate in actinic cheilitis with different grades of epithelial dysplasia. 61
32133685 2020
24
In Vivo Reflectance Confocal Microscopy-Diagnostic Criteria for Actinic Cheilitis and Squamous Cell Carcinoma of the Lip. 61
32630380 2020
25
Modification in CLIC4 Expression is Associated with P53, TGF-β, TNF-α and Myofibroblasts in Lip Carcinogenesis. 61
32667519 2020
26
A retrospective 11-year study on lip lesions attended at an oral diagnostic service. 61
32040463 2020
27
Clinical evaluation and efficacy of Imiquimod 3.75% cream for the treatment of actinic keratosis, pigmented basal cell carcinomas, and actinic cheilitis. 61
32239714 2020
28
Ingenol mebutate treatment for actinic cheilitis: clinical, histopathological and p53 profile of 14 cases. 61
32072836 2020
29
Oral potentially malignant disorders: clinical-pathological study of 684 cases diagnosed in a Brazilian population. 61
31880285 2020
30
Can immunohistochemical biomarkers distinguish epithelial dysplasia degrees in actinic cheilitis? A systematic review and meta-analysis. 61
31880283 2020
31
Actinic cheilitis: Morphometric parameters and its relationship with the degree of epithelial dysplasia. 61
31558280 2020
32
Detection of human papillomaviruses and human polyomaviruses in immunosuppressed and immunocompetent individuals with actinic cheilitis: a case series. 61
31281986 2019
33
Herpes simplex reactivation after photodynamic therapy for actinic cheilitis in a patient with non-Hodgkin lymphoma: a possible indication for prophylaxis. 61
29512976 2019
34
Proper management of suspicious actinic cheilitis. 61
31032237 2019
35
Patch Testing for Cheilitis: A 10-Year Series. 61
31609855 2019
36
High rate of clinical improvement of actinic cheilitis with laser, surgery, and chemotherapeutic agents in patients who have a favorable prognosis. 61
31519297 2019
37
Fludroxycortide cream as an alternative therapy for actinic cheilitis. 61
30673866 2019
38
[Potentially malignant disorders of the oral mucosa]. 61
32237647 2019
39
Actinic Cheilitis: Analysis of Clinical Subtypes, Risk Factors and Associated Signs of Actinic Damage. 61
31197386 2019
40
Use of lip photoprotection in patients suffering from actinic cheilitis. 61
31475909 2019
41
Immunoexpression of human leukocyte antigen-DR in actinic cheilitis and lower lip squamous cell carcinoma. 61
31483051 2019
42
DNA Repair Enzyme Containing Lip Balm for the Treatment of Actinic Cheilitis: A Pilot Study 61
31251551 2019
43
Treatment of actinic cheilitis: a systematic review. 61
31011833 2019
44
Surgical versus non-surgical treatment of actinic cheilitis: A systematic review and meta-analysis. 61
29908101 2019
45
Plasma cell cheilitis: the diagnosis of a disorder mimicking lip cancer. 61
30963053 2019
46
Ingenol mebutate versus imiquimod versus diclofenac for actinic cheilitis: a 6-month follow-up clinical study. 61
30242791 2019
47
Immune response and evasion mechanisms in lip carcinogenesis: An immunohistochemical study. 61
30468994 2019
48
Daylight photodynamic therapy for the treatment of actinic cheilitis. 61
30066408 2019
49
Evidence regarding how surgical treatment of actinic cheilitis compares with nonsurgical treatment is not trustworthy and does not consider all important outcomes. 61
30119827 2019
50
Actinic cheilitis and lip squamous cell carcinoma: Literature review and new data from Brazil. 61
30697396 2019

Variations for Actinic Cheilitis

Expression for Actinic Cheilitis

Search GEO for disease gene expression data for Actinic Cheilitis.

Pathways for Actinic Cheilitis

Pathways related to Actinic Cheilitis according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.18 TP53 MDM2 FGFR3 CDKN1A
2
Show member pathways
12.91 TP53 MDM2 FGFR3 CDKN1A
3
Show member pathways
12.78 TP53 MDM2 FGFR3 CDKN1A
4
Show member pathways
12.76 TP53 MSH2 MDM2 CDKN1A
5
Show member pathways
12.66 TP53 MSH2 MDM2 CDKN1A
6 12.56 TP53 MSH2 MDM2 FGFR3 CDKN1A
7
Show member pathways
12.52 TP53 MDM2 CDKN1A
8
Show member pathways
12.52 TP53 MDM2 FGFR3 CDKN1A
9
Show member pathways
12.5 TP53 MDM2 CDKN1A
10
Show member pathways
12.46 TP53 MDM2 CDKN1A
11
Show member pathways
12.41 TP53 MSH2 CDKN1A
12
Show member pathways
12.39 TP53 MDM2 CDKN1A
13
Show member pathways
12.39 TP53 MDM2 FGFR3 CDKN1A
14
Show member pathways
12.33 TP53 MDM2 FGFR3
15
Show member pathways
12.33 TP53 MSH2 MDM2 CDKN1A APEX1
16 12.3 TP53 MDM2 FGFR3 CDKN1A
17
Show member pathways
12.28 TP53 MDM2 FGFR3
18
Show member pathways
12.24 TP53 MDM2 CDKN1A
19
Show member pathways
12.22 TP53 MDM2 CDKN1A
20 12.21 TP53 MDM2 CDKN1A
21
Show member pathways
12.16 TP53 MDM2 CDKN1A
22 12.15 TP53 MDM2 CDKN1A
23 12.14 TP53 MDM2 CDKN1A
24 12.13 TP53 MSH2 MDM2 CDKN1A APEX1
25 12.11 TP53 MDM2 CDKN1A
26
Show member pathways
12.09 TP53 MDM2 CDKN1A
27 12.03 TP53 MSH2 CDKN1A
28
Show member pathways
12.01 TP53 MDM2 FGFR3 CDKN1A
29 12 TP53 MDM2 CDKN1A
30 11.99 TP53 MSH2 MDM2
31 11.84 TP53 MDM2 CDKN1A
32 11.82 TP53 MDM2 CDKN1A
33 11.79 TP53 MDM2 CDKN1A
34 11.79 TP53 MSH2 MDM2 CDKN1A
35 11.69 TP53 MDM2 CDKN1A
36
Show member pathways
11.67 TP53 MDM2 CDKN1A
37 11.64 TP53 MDM2 CDKN1A
38 11.57 TP53 FGFR3
39 11.49 TP53 MDM2
40 11.49 TP53 MDM2 CDKN1A APEX1
41 11.47 MDM2 CDKN1A
42
Show member pathways
11.45 TP53 MDM2
43 11.45 TP53 MDM2
44 11.42 TP53 CDKN1A
45 11.42 TP53 CDKN1A
46 11.41 TP53 CDKN1A
47 11.4 TP53 MDM2 APEX1
48
Show member pathways
11.35 MSH2 APEX1
49 11.32 TP53 MSH2 MDM2 CDKN1A
50
Show member pathways
11.3 TP53 MSH2

GO Terms for Actinic Cheilitis

Cellular components related to Actinic Cheilitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleolus GO:0005730 9.26 TP53 MDM2 CDKN1A APEX1
2 nuclear body GO:0016604 8.8 TP53 MDM2 CDKN1A

Biological processes related to Actinic Cheilitis according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.79 TP53 MDM2 CDKN1A
2 cellular response to DNA damage stimulus GO:0006974 9.76 TP53 MSH2 CDKN1A APEX1
3 heart development GO:0007507 9.75 TP53 MDM2 CDKN1A
4 response to drug GO:0042493 9.67 TP53 MDM2 CDKN1A APEX1
5 cell cycle arrest GO:0007050 9.65 TP53 MSH2 CDKN1A
6 cellular response to hydrogen peroxide GO:0070301 9.63 MDM2 APEX1
7 double-strand break repair GO:0006302 9.63 TP53 MSH2
8 response to UV GO:0009411 9.62 TP53 CDKN1A
9 cellular response to ionizing radiation GO:0071479 9.61 TP53 CDKN1A
10 response to organonitrogen compound GO:0010243 9.61 CDKN1A APEX1
11 response to antibiotic GO:0046677 9.6 TP53 MDM2
12 positive regulation of reactive oxygen species metabolic process GO:2000379 9.59 TP53 CDKN1A
13 intrinsic apoptotic signaling pathway GO:0097193 9.58 TP53 CDKN1A
14 cellular response to peptide hormone stimulus GO:0071375 9.57 MDM2 APEX1
15 positive regulation of protein export from nucleus GO:0046827 9.56 TP53 MDM2
16 determination of adult lifespan GO:0008340 9.55 TP53 MSH2
17 mitotic cell cycle arrest GO:0071850 9.54 TP53 CDKN1A
18 replicative senescence GO:0090399 9.52 TP53 CDKN1A
19 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.51 TP53 CDKN1A
20 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.5 TP53 MDM2 CDKN1A
21 cardiac septum morphogenesis GO:0060411 9.49 TP53 MDM2
22 cellular response to UV-C GO:0071494 9.43 TP53 MDM2
23 signal transduction by p53 class mediator GO:0072331 9.4 TP53 CDKN1A
24 cellular response to gamma radiation GO:0071480 9.33 TP53 MDM2 CDKN1A
25 cellular response to actinomycin D GO:0072717 9.26 TP53 MDM2
26 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.13 TP53 MSH2 CDKN1A
27 response to X-ray GO:0010165 8.8 TP53 MSH2 CDKN1A

Molecular functions related to Actinic Cheilitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.33 TP53 MSH2 MDM2
2 p53 binding GO:0002039 9.32 TP53 MDM2
3 damaged DNA binding GO:0003684 9.26 MSH2 APEX1
4 disordered domain specific binding GO:0097718 8.96 TP53 MDM2
5 ubiquitin protein ligase binding GO:0031625 8.8 TP53 MDM2 CDKN1A

Sources for Actinic Cheilitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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