MCID: ACT093
MIFTS: 45

Actinic Cheilitis

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Actinic Cheilitis

MalaCards integrated aliases for Actinic Cheilitis:

Name: Actinic Cheilitis 53 73
Actinic Cheilosis 53

Classifications:



External Ids:

UMLS 73 C0267026

Summaries for Actinic Cheilitis

MalaCards based summary : Actinic Cheilitis, also known as actinic cheilosis, is related to cheilitis and lip cancer. An important gene associated with Actinic Cheilitis is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Akt Signaling and PI3K/AKT activation. The drugs Aminolevulinic acid and Imiquimod have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and brain, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and cellular

Wikipedia : 76 Actinic cheilitis (abbreviated to AC, also termed actinic cheilosis,actinic keratosis of lip,solar... more...

Related Diseases for Actinic Cheilitis

Diseases related to Actinic Cheilitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 cheilitis 31.5 MDM2 MSH2 TP53
2 lip cancer 29.9 CDKN1A MDM2 MSH2 TP53
3 squamous cell carcinoma 10.6
4 angular cheilitis 10.3
5 ring chromosome 7 10.1 MDM2 TP53
6 zika virus infection 10.1 MDM2 TP53
7 sclerosing liposarcoma 10.1 MDM2 TP53
8 liposarcoma 10.1 MDM2 TP53
9 periosteal osteogenic sarcoma 10.1 MDM2 TP53
10 gliomatosis cerebri 10.1 MDM2 TP53
11 soft tissue sarcoma 10.1 MDM2 TP53
12 dedifferentiated liposarcoma 10.1 MDM2 TP53
13 small cell sarcoma 10.1 MDM2 TP53
14 myxosarcoma 10.1 MDM2 TP53
15 verrucous carcinoma 10.1 MDM2 TP53
16 embryonal sarcoma 10.1 MDM2 TP53
17 cardia cancer 10.1 MDM2 TP53
18 lung papillary adenocarcinoma 10.1 ERCC1 TP53
19 invasive bladder transitional cell carcinoma 10.1 CDKN1A TP53
20 bladder transitional cell papilloma 10.1 CDKN1A TP53
21 atypical follicular adenoma 10.1 CDKN1A TP53
22 adult medulloblastoma 10.1 MDM2 TP53
23 suppressor of tumorigenicity 3 10.1 CDKN1A TP53
24 cellular schwannoma 10.1 MDM2 TP53
25 muscle cancer 10.1 MDM2 TP53
26 connective tissue cancer 10.1 MDM2 TP53
27 supratentorial cancer 10.1 MDM2 TP53
28 cerebrum cancer 10.1 MDM2 TP53
29 nodular ganglioneuroblastoma 10.1 CDKN1A MDM2
30 primary peritoneal carcinoma 10.1 ERCC1 TP53
31 myxoid liposarcoma 10.1 MDM2 TP53
32 grade iii astrocytoma 10.1 MDM2 TP53
33 histiocytoma 10.1 MDM2 TP53
34 cervical adenocarcinoma 10.1 CDKN1A TP53
35 cerebral primitive neuroectodermal tumor 10.1 MSH2 TP53
36 intestinal benign neoplasm 10.0 MSH2 TP53
37 anaplastic thyroid cancer 10.0 CDKN1A TP53
38 inflammatory myofibroblastic tumor 10.0 MDM2 TP53
39 pleomorphic adenoma 10.0 MDM2 TP53
40 tongue cancer 10.0 CDKN1A TP53
41 familial colorectal cancer 10.0 MSH2 TP53
42 uterine anomalies 10.0 MSH2 TP53
43 leiomyosarcoma 10.0 MDM2 TP53
44 colorectal adenoma 10.0 MSH2 TP53
45 non-invasive bladder papillary urothelial neoplasm 10.0 FGFR3 TP53
46 bladder papillary transitional cell neoplasm 10.0 FGFR3 TP53
47 urinary tract papillary transitional cell benign neoplasm 10.0 FGFR3 TP53
48 colonic disease 10.0 MSH2 TP53
49 colorectal adenocarcinoma 10.0 MSH2 TP53
50 cervix carcinoma 10.0 FGFR3 TP53

Graphical network of the top 20 diseases related to Actinic Cheilitis:



Diseases related to Actinic Cheilitis

Symptoms & Phenotypes for Actinic Cheilitis

GenomeRNAi Phenotypes related to Actinic Cheilitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.02 CDKN1A ERCC1 MDM2 MSH2 TP53

MGI Mouse Phenotypes related to Actinic Cheilitis:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.02 CDKN1A ERCC1 FGFR3 MDM2 MSH2 TP53
2 hematopoietic system MP:0005397 9.99 CDKN1A ERCC1 FGFR3 MDM2 MSH2 TP53
3 homeostasis/metabolism MP:0005376 9.97 CDKN1A ERCC1 FGFR3 MDM2 MSH2 TP53
4 immune system MP:0005387 9.95 CDKN1A ERCC1 FGFR3 MDM2 MSH2 TP53
5 integument MP:0010771 9.93 CDKN1A ERCC1 FGFR3 MDM2 MSH2 TP53
6 digestive/alimentary MP:0005381 9.92 CDKN1A FGFR3 MDM2 MSH2 TP53
7 mortality/aging MP:0010768 9.85 CDKN1A ERCC1 FGFR3 MDM2 MSH2 TP53
8 craniofacial MP:0005382 9.84 CDKN1A FGFR3 MDM2 TP53
9 neoplasm MP:0002006 9.8 CDKN1A ERCC1 FGFR3 MDM2 MSH2 TP53
10 limbs/digits/tail MP:0005371 9.73 CDKN1A FGFR3 MDM2 TP53
11 liver/biliary system MP:0005370 9.71 CDKN1A ERCC1 MDM2 TP53
12 no phenotypic analysis MP:0003012 9.56 CDKN1A FGFR3 MDM2 TP53
13 renal/urinary system MP:0005367 9.55 CDKN1A ERCC1 FGFR3 MDM2 TP53
14 reproductive system MP:0005389 9.35 CDKN1A ERCC1 FGFR3 MDM2 TP53
15 skeleton MP:0005390 9.02 CDKN1A ERCC1 FGFR3 MDM2 TP53

Drugs & Therapeutics for Actinic Cheilitis

Drugs for Actinic Cheilitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aminolevulinic acid Approved Phase 4,Phase 1 106-60-5 137
2
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
3 Photosensitizing Agents Phase 4,Phase 1
4 Dermatologic Agents Phase 4,Phase 1
5 Immunologic Factors Phase 4
6 Methyl 5-aminolevulinate Phase 4,Phase 1
7 Interferon Inducers Phase 4
8 Adjuvants, Immunologic Phase 4
9 interferons Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Photodynamic Therapy (PDT) With Levulan and Blue Light for the Treatment of Actinic Cheilitis Completed NCT02409732 Phase 4 aminolevulinic acid hydrochloride
2 Treatment Study for Actinic Cheilitis Comparing Imiquimod 5% and Photodynamic Therapy Completed NCT00849992 Phase 4 Imiquimod 5%
3 Photodynamic Therapy to Treat Actinic Damage in Patients With Squamous Cell Carcinoma (SCC) of the Lip Completed NCT00868088 Phase 4
4 Evaluation of Ingenol Mebutate for Actinic Cheilitis Treatment Not yet recruiting NCT03452566 Phase 1, Phase 2 Ingenol mebutate gel
5 Study of Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Laser in Actinic Cheilitis Completed NCT02198469 Phase 1 Er:YAG AFL-PDT;MAL-PDT
6 Actinic Cheilitis Pre-Treated With DNA Repair Enzyme Cream Withdrawn NCT03224715 Not Applicable

Search NIH Clinical Center for Actinic Cheilitis

Genetic Tests for Actinic Cheilitis

Anatomical Context for Actinic Cheilitis

MalaCards organs/tissues related to Actinic Cheilitis:

41
Lung, Skin, Brain, Bone, Colon, Thyroid, Thymus

Publications for Actinic Cheilitis

Articles related to Actinic Cheilitis:

(show top 50) (show all 159)
# Title Authors Year
1
Prevalence of and Factors Associated with Actinic Cheilitis in Extractive Mining Workers. ( 29898071 )
2018
2
Surgical versus non-surgical treatment of actinic cheilitis: a systematic review and meta-analysis. ( 29908101 )
2018
3
Non-invasive imaging of actinic cheilitis and squamous cell carcinoma of the lip. ( 29725529 )
2018
4
Expression of cancer stem cell markers CD44, ALDH1 and p75NTR in actinic cheilitis and lip cancer. ( 29779037 )
2018
5
Expression of stem cell markers Nanog and Nestin in lip squamous cell carcinoma and actinic cheilitis. ( 29761881 )
2018
6
Erratum: Time-resolved fluorescence spectroscopy for clinical diagnosis of actinic cheilitis: erratum. ( 29552401 )
2018
7
Evaluation of Cellular Proliferative Activity in Patients with Actinic Cheilitis through Silver-stained Nucleolar Organizer Region Method. ( 29728540 )
2018
8
Immunoexpression of glucocorticoid receptor alpha (GRI+) isoform and apoptotic proteins (Bcl-2 and Bax) in actinic cheilitis and lower lip squamous cell carcinoma. ( 29935090 )
2018
9
Dermoscopy and reflectance confocal microscopy for monitoring the treatment of actinic cheilitis with ingenol mebutate gel: Report of three cases. ( 29687567 )
2018
10
Malignant transformation of actinic cheilitis: A systematic review of observational studies. ( 29863311 )
2018
11
Herpes simplex reactivation after photodynamic therapy for actinic cheilitis in a patient with Non-Hodgkin Lymphoma: a possible indication for prophylaxis. ( 29512976 )
2018
12
Daylight photodynamic therapy for the treatment of actinic cheilitis. ( 30066408 )
2018
13
Actinic Cheilitis Prevalence and Risk Factors: A Cross-sectional, Multicentre Study in a Population Aged 45 Years and Over in North-west Spain. ( 30085328 )
2018
14
Evidence regarding how surgical treatment of actinic cheilitis compares with nonsurgical treatment is not trustworthy and does not consider all important outcomes. ( 30119827 )
2018
15
Ingenol mebutate versus imiquimod versus diclofenac for actinic cheilitis: a 6-month follow-up clinical study. ( 30242791 )
2018
16
CD8+ and FoxP3+ T-cell infiltration in actinic cheilitis. ( 27778327 )
2017
17
5-aminolaevulinic acid patch-photodynamic therapy in the treatment of actinic cheilitis. ( 28703320 )
2017
18
Immunoexpression of HDAC1, HDAC2, and HAT1 in actinic cheilitis and lip squamous cell carcinoma. ( 28107582 )
2017
19
Actinic cheilitis: proposition and reproducibility of a clinical criterion. ( 29607086 )
2017
20
Diclofenac sodium gel therapy as an alternative to actinic cheilitis. ( 28986686 )
2017
21
Management of actinic cheilitis using ingenol mebutate gel: A report of seven cases. ( 27241280 )
2017
22
Actinic cheilosis: early intervention prevents malignant transformation. ( 28320702 )
2017
23
Automated algorithm for actinic cheilitis diagnosis by wide-field fluorescence imaging. ( 27981067 )
2016
24
Immunohistochemical expression of DNA methyltransferases 1, 3a, and 3b in actinic cheilitis and lip squamous cell carcinomas. ( 27159259 )
2016
25
Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer. ( 26842232 )
2016
26
Histopathologic features in actinic cheilitis by the comparison of grading dysplasia systems. ( 27759902 )
2016
27
A comparative study using WHO and binary oral epithelial dysplasia grading systems in actinic cheilitis. ( 27029007 )
2016
28
Evaluation of hypoxia, angiogenesis, and lymphangiogenesis in actinic cheilitis. ( 27420649 )
2016
29
Evaluation of the efficacy of photodynamic therapy for the treatment of actinic cheilitis. ( 27864997 )
2016
30
Time-resolved fluorescence spectroscopy for clinical diagnosis of actinic cheilitis. ( 27867726 )
2016
31
Optical diagnosis of actinic cheilitis by infrared spectroscopy. ( 27491855 )
2016
32
Ingenol Mebutate for Recalcitrant Chronic Actinic Cheilitis. ( 27513668 )
2016
33
Link between immunoexpression of hMLH1 and hMSH2 proteins and clinical-epidemiological aspects of actinic cheilitis. ( 27579741 )
2016
34
Pattern of galectins expression in actinic cheilitis with different risks of malignant transformation. ( 26711374 )
2016
35
Value of videoroscopy in the detection of alterations of Actinic Cheilitis and the selection of biopsy areas. ( 25662549 )
2015
36
Clinicopathological profile and management of 161 cases of actinic cheilitis. ( 26375219 )
2015
37
Daylight photodynamic therapy with methyl-aminolevulinate for the treatment of actinic cheilitis. ( 26179312 )
2015
38
Treatment of actinic cheilitis with methyl aminolevulinate photodynamic therapy and light fractionation: a prospective study of 10 patients. ( 26677980 )
2015
39
Loss of cytokeratin 10 indicates malignant transformation in actinic cheilitis. ( 26264639 )
2015
40
Treatment of Actinic Cheilitis. ( 26418628 )
2015
41
Commentary on photodynamic therapy of actinic cheilitis. ( 25654194 )
2015
42
Ablative fractional laser assisted photodynamic therapy for the treatment of actinic cheilitis. ( 26174644 )
2015
43
Immunohistochemical expression of matrix metalloproteinase-1, matrix metalloproteinase-2 and matrix metalloproteinase-9, myofibroblasts and Ki-67 in actinic cheilitis and lip squamous cell carcinoma. ( 26515234 )
2015
44
Ingenol mebutate gel treatment for actinic cheilitis: report of four cases. ( 25545762 )
2015
45
Photodynamic therapy for actinic cheilitis: a systematic review. ( 25627629 )
2015
46
Prevalence of and risk factors for actinic cheilitis in Brazilian fishermen and women. ( 25039599 )
2014
47
Efficacy of ablative fractional laser-assisted photodynamic therapy for the treatment of actinic cheilitis: 12-month follow-up results of a prospective, randomised, comparative trial. ( 25400009 )
2014
48
Dermoscopic features of plasma cell cheilitis and actinic cheilitis. ( 24474043 )
2014
49
Study of MDM2 and SUMO-1 expression in actinic cheilitis and lip cancer. ( 25241153 )
2014
50
Regulatory T cells in the actinic cheilitis. ( 25060152 )
2014

Variations for Actinic Cheilitis

Cosmic variations for Actinic Cheilitis:

9 (show top 50) (show all 1103)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM45353 TP53 upper aerodigestive tract,mouth,other,actinic cheilitis c.673G>A p.V225I 17:7674290-7674290 4
2 COSM44129 TP53 upper aerodigestive tract,mouth,other,actinic cheilitis c.729G>A p.M243I 17:7674234-7674234 4
3 COSM714 FGFR3 upper aerodigestive tract,mouth,other,actinic cheilitis c.742C>T p.R248C 4:1801837-1801837 4
4 COSM29448 FGFR3 upper aerodigestive tract,mouth,other,actinic cheilitis c.1888G>A p.V630M 4:1806102-1806102 4
5 COSM29449 FGFR3 upper aerodigestive tract,mouth,other,actinic cheilitis c.1941C>T p.Y647Y 4:1806155-1806155 4
6 COSM29445 FGFR3 upper aerodigestive tract,mouth,other,actinic cheilitis c.2056G>A p.E686K 4:1806571-1806571 4
7 COSM29447 FGFR3 upper aerodigestive tract,mouth,other,actinic cheilitis c.1839C>T p.C613C 4:1806053-1806053 4
8 COSM29446 FGFR3 upper aerodigestive tract,mouth,other,actinic cheilitis c.753C>T p.H251H 4:1801848-1801848 4
9 COSM3724309 ZNF536 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.1935G>C p.Q645H 19:30445497-30445497 3
10 COSM6976115 YES1 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.1288C>T p.Q430* 18:736811-736811 3
11 COSM6914703 XPO1 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.619C>G p.Q207E 2:61498885-61498885 3
12 COSM6957917 TSC2 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.1120A>T p.T374S 16:2061871-2061871 3
13 COSM121050 TP63 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.551C>T p.S184L 3:189808498-189808498 3
14 COSM10645 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.527G>T p.C176F 17:7675085-7675085 3
15 COSM69404 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.994-1G>A p.? 17:7670716-7670716 3
16 COSM43708 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.422G>A p.C141Y 17:7675190-7675190 3
17 COSM11073 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.1024C>T p.R342* 17:7670685-7670685 3
18 COSM43947 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.614A>G p.Y205C 17:7674917-7674917 3
19 COSM10660 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.818G>A p.R273H 17:7673802-7673802 3
20 COSM45607 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.676G>A p.G226S 17:7674287-7674287 3
21 COSM43592 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.395A>T p.K132M 17:7675217-7675217 3
22 COSM45794 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.421T>G p.C141G 17:7675191-7675191 3
23 COSM43850 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.659A>C p.Y220S 17:7674872-7674872 3
24 COSM43606 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.734G>A p.G245D 17:7674229-7674229 3
25 COSM10958 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.797G>T p.G266V 17:7673823-7673823 3
26 COSM44351 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.572C>T p.P191L 17:7674959-7674959 3
27 COSM10648 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.524G>A p.R175H 17:7675088-7675088 3
28 COSM11084 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.517G>A p.V173M 17:7675095-7675095 3
29 COSM43665 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.746G>C p.R249T 17:7674217-7674217 3
30 COSM10756 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.827C>T p.A276V 17:7673793-7673793 3
31 COSM10663 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.916C>T p.R306* 17:7673704-7673704 3
32 COSM10659 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.817C>T p.R273C 17:7673803-7673803 3
33 COSM45618 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.931A>C p.N311H 17:7673597-7673597 3
34 COSM43695 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.748C>T p.P250S 17:7674215-7674215 3
35 COSM44229 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.515T>A p.V172D 17:7675097-7675097 3
36 COSM10704 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.844C>T p.R282W 17:7673776-7673776 3
37 COSM44935 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.724T>A p.C242S 17:7674239-7674239 3
38 COSM10758 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.659A>G p.Y220C 17:7674872-7674872 3
39 COSM43714 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.836G>A p.G279E 17:7673784-7673784 3
40 COSM10646 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.725G>A p.C242Y 17:7674238-7674238 3
41 COSM43743 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.914A>G p.K305R 17:7673706-7673706 3
42 COSM10905 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.451C>T p.P151S 17:7675161-7675161 3
43 COSM10656 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.742C>T p.R248W 17:7674221-7674221 3
44 COSM10735 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.638G>A p.R213Q 17:7674893-7674893 3
45 COSM10662 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.743G>A p.R248Q 17:7674220-7674220 3
46 COSM44823 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.981T>G p.Y327* 17:7673547-7673547 3
47 COSM43906 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.843C>A p.D281E 17:7673777-7673777 3
48 COSM10724 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.839G>C p.R280T 17:7673781-7673781 3
49 COSM43680 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.523C>T p.R175C 17:7675089-7675089 3
50 COSM43559 TP53 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.517G>T p.V173L 17:7675095-7675095 3

Expression for Actinic Cheilitis

Search GEO for disease gene expression data for Actinic Cheilitis.

Pathways for Actinic Cheilitis

Pathways related to Actinic Cheilitis according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.18 CDKN1A FGFR3 MDM2 TP53
2
Show member pathways
12.91 CDKN1A FGFR3 MDM2 TP53
3
Show member pathways
12.8 CDKN1A FGFR3 MDM2 TP53
4
Show member pathways
12.77 CDKN1A MDM2 MSH2 TP53
5
Show member pathways
12.65 CDKN1A MDM2 MSH2 TP53
6
Show member pathways
12.61 CDKN1A MDM2 TP53
7
Show member pathways
12.56 CDKN1A FGFR3 MDM2 TP53
8 12.55 CDKN1A FGFR3 MDM2 MSH2 TP53
9
Show member pathways
12.5 CDKN1A FGFR3 MDM2 TP53
10
Show member pathways
12.46 CDKN1A MDM2 TP53
11
Show member pathways
12.42 CDKN1A MSH2 TP53
12
Show member pathways
12.4 CDKN1A MDM2 TP53
13
Show member pathways
12.33 CDKN1A ERCC1 MDM2 MSH2 TP53
14
Show member pathways
12.32 CDKN1A MDM2 TP53
15
Show member pathways
12.29 FGFR3 MDM2 TP53
16 12.29 CDKN1A FGFR3 MDM2 TP53
17
Show member pathways
12.24 CDKN1A MDM2 TP53
18
Show member pathways
12.22 CDKN1A MDM2 TP53
19 12.21 CDKN1A MDM2 TP53
20 12.15 CDKN1A MDM2 TP53
21 12.14 CDKN1A MDM2 TP53
22 12.14 CDKN1A MDM2 TP53
23 12.13 CDKN1A ERCC1 MDM2 MSH2 TP53
24 12.1 CDKN1A MDM2 TP53
25
Show member pathways
12.09 CDKN1A MDM2 TP53
26 12.02 CDKN1A MSH2 TP53
27 12 CDKN1A MDM2 TP53
28 11.98 MDM2 MSH2 TP53
29
Show member pathways
11.98 CDKN1A FGFR3 MDM2 TP53
30 11.91 CDKN1A FGFR3 MDM2 TP53
31 11.9 CDKN1A MDM2 TP53
32 11.84 CDKN1A MDM2 TP53
33 11.81 CDKN1A MDM2 TP53
34 11.79 CDKN1A MDM2 MSH2 TP53
35 11.77 CDKN1A MDM2 TP53
36 11.67 CDKN1A MDM2 TP53
37
Show member pathways
11.65 CDKN1A MDM2 TP53
38 11.61 CDKN1A MDM2 TP53
39
Show member pathways
11.59 MDM2 TP53
40 11.54 FGFR3 TP53
41 11.54 CDKN1A MDM2 TP53
42 11.5 MDM2 TP53
43 11.47 CDKN1A MDM2
44 11.45 MDM2 TP53
45 11.45 MDM2 TP53
46
Show member pathways
11.45 MDM2 TP53
47 11.42 CDKN1A TP53
48 11.42 CDKN1A TP53
49 11.41 CDKN1A TP53
50 11.32 CDKN1A FGFR3 MDM2 TP53

GO Terms for Actinic Cheilitis

Cellular components related to Actinic Cheilitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor TFIID complex GO:0005669 8.96 ERCC1 TP53
2 nuclear body GO:0016604 8.8 CDKN1A MDM2 TP53

Biological processes related to Actinic Cheilitis according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.76 CDKN1A FGFR3 MDM2 TP53
2 cellular response to DNA damage stimulus GO:0006974 9.67 CDKN1A ERCC1 MSH2 TP53
3 Ras protein signal transduction GO:0007265 9.62 CDKN1A TP53
4 double-strand break repair GO:0006302 9.61 ERCC1 MSH2
5 interstrand cross-link repair GO:0036297 9.61 ERCC1 MSH2
6 cell cycle arrest GO:0007050 9.61 CDKN1A MSH2 TP53
7 nucleotide-excision repair GO:0006289 9.6 ERCC1 TP53
8 germ cell development GO:0007281 9.59 ERCC1 MSH2
9 cellular response to ionizing radiation GO:0071479 9.58 CDKN1A TP53
10 intrinsic apoptotic signaling pathway GO:0097193 9.58 CDKN1A TP53
11 response to antibiotic GO:0046677 9.57 MDM2 TP53
12 positive regulation of reactive oxygen species metabolic process GO:2000379 9.56 CDKN1A TP53
13 cellular response to gamma radiation GO:0071480 9.55 MDM2 TP53
14 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.54 MSH2 TP53
15 positive regulation of protein export from nucleus GO:0046827 9.52 MDM2 TP53
16 isotype switching GO:0045190 9.51 ERCC1 MSH2
17 determination of adult lifespan GO:0008340 9.49 MSH2 TP53
18 replicative senescence GO:0090399 9.48 CDKN1A TP53
19 mitotic recombination GO:0006312 9.4 ERCC1 MSH2
20 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.33 CDKN1A MDM2 TP53
21 signal transduction by p53 class mediator GO:0072331 9.32 CDKN1A TP53
22 meiotic mismatch repair GO:0000710 9.26 ERCC1 MSH2
23 cellular response to actinomycin D GO:0072717 8.96 MDM2 TP53
24 response to X-ray GO:0010165 8.8 CDKN1A ERCC1 MSH2

Molecular functions related to Actinic Cheilitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.58 CDKN1A MSH2 TP53
2 enzyme binding GO:0019899 9.43 MDM2 MSH2 TP53
3 damaged DNA binding GO:0003684 9.37 ERCC1 MSH2
4 p53 binding GO:0002039 9.32 MDM2 TP53
5 disordered domain specific binding GO:0097718 9.16 MDM2 TP53
6 ubiquitin protein ligase binding GO:0031625 9.13 CDKN1A MDM2 TP53
7 TFIID-class transcription factor complex binding GO:0001094 8.62 ERCC1 TP53

Sources for Actinic Cheilitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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