Aliases & Classifications for Actinic Cheilitis

MalaCards integrated aliases for Actinic Cheilitis:

Name: Actinic Cheilitis 53 73
Actinic Cheilosis 53

Classifications:



External Ids:

UMLS 73 C0267026

Summaries for Actinic Cheilitis

MalaCards based summary : Actinic Cheilitis, also known as actinic cheilosis, is related to cheilitis and lip cancer. An important gene associated with Actinic Cheilitis is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Akt Signaling and PI3K-Akt signaling pathway. The drugs Aminolevulinic acid and Imiquimod have been mentioned in the context of this disorder. Affiliated tissues include t cells and salivary gland, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and cellular

Wikipedia : 76 Actinic cheilitis (abbreviated to AC, also termed actinic cheilosis,actinic keratosis of lip,solar... more...

Related Diseases for Actinic Cheilitis

Diseases related to Actinic Cheilitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 cheilitis 31.0 MDM2 MSH2 TP53
2 lip cancer 29.7 MDM2 MSH2 TP53
3 ring chromosome 7 10.5 MDM2 TP53
4 zika virus infection 10.5 MDM2 TP53
5 squamous cell carcinoma 10.5
6 sclerosing liposarcoma 10.4 MDM2 TP53
7 periosteal osteogenic sarcoma 10.4 MDM2 TP53
8 dedifferentiated liposarcoma 10.4 MDM2 TP53
9 gliomatosis cerebri 10.4 MDM2 TP53
10 soft tissue sarcoma 10.4 MDM2 TP53
11 small cell sarcoma 10.4 MDM2 TP53
12 myxosarcoma 10.4 MDM2 TP53
13 embryonal sarcoma 10.4 MDM2 TP53
14 adult medulloblastoma 10.4 MDM2 TP53
15 invasive bladder transitional cell carcinoma 10.4 CDKN1A TP53
16 bladder transitional cell papilloma 10.4 CDKN1A TP53
17 cellular schwannoma 10.4 MDM2 TP53
18 atypical follicular adenoma 10.4 CDKN1A TP53
19 giant cell glioblastoma 10.4 MDM2 TP53
20 muscle cancer 10.4 MDM2 TP53
21 connective tissue cancer 10.3 MDM2 TP53
22 suppressor of tumorigenicity 3 10.3 CDKN1A TP53
23 nodular ganglioneuroblastoma 10.3 CDKN1A MDM2
24 myxoid liposarcoma 10.3 MDM2 TP53
25 grade iii astrocytoma 10.3 MDM2 TP53
26 in situ carcinoma 10.3 ITGB4 TP53
27 tongue cancer 10.3 CDKN1A TP53
28 histiocytoma 10.3 MDM2 TP53
29 anaplastic thyroid cancer 10.3 CDKN1A TP53
30 inflammatory myofibroblastic tumor 10.2 MDM2 TP53
31 cervical adenocarcinoma 10.2 CDKN1A TP53
32 pleomorphic adenoma 10.2 MDM2 TP53
33 cerebral primitive neuroectodermal tumor 10.2 MSH2 TP53
34 intestinal benign neoplasm 10.2 MSH2 TP53
35 leiomyosarcoma 10.2 MDM2 TP53
36 familial colorectal cancer 10.1 MSH2 TP53
37 liposarcoma 10.1 MDM2 TP53
38 colorectal adenoma 10.1 MSH2 TP53
39 hereditary breast ovarian cancer syndrome 10.1 MSH2 TP53
40 colorectal adenocarcinoma 10.0 MSH2 TP53
41 female reproductive organ cancer 10.0 MSH2 TP53
42 meningeal melanomatosis 10.0 PDCD1 TP53
43 autosomal genetic disease 10.0 MSH2 TP53
44 malignant peripheral nerve sheath tumor 9.9 MDM2 TP53
45 malignant mesenchymoma 9.9 CDKN1A MDM2 TP53
46 retinal cancer 9.9 CDKN1A MDM2 TP53
47 sensory system cancer 9.9 CDKN1A MDM2 TP53
48 ocular cancer 9.9 CDKN1A MDM2 TP53
49 nervous system cancer 9.9 CDKN1A MDM2 TP53
50 li-fraumeni syndrome 9.9 CDKN1A MDM2 TP53

Graphical network of the top 20 diseases related to Actinic Cheilitis:



Diseases related to Actinic Cheilitis

Symptoms & Phenotypes for Actinic Cheilitis

GenomeRNAi Phenotypes related to Actinic Cheilitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 8.92 CDKN1A MDM2 MSH2 TP53

MGI Mouse Phenotypes related to Actinic Cheilitis:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10 MSH2 ITGB4 PDCD1 MDM2 CDKN1A TP53
2 homeostasis/metabolism MP:0005376 9.95 CDKN1A MSH2 ITGB4 PDCD1 MDM2 TP53
3 cardiovascular system MP:0005385 9.93 CDKN1A ITGB4 PDCD1 MDM2 TP53
4 immune system MP:0005387 9.93 MSH2 ITGB4 PDCD1 MDM2 CDKN1A TP53
5 digestive/alimentary MP:0005381 9.89 MSH2 ITGB4 MDM2 CDKN1A TP53
6 mortality/aging MP:0010768 9.85 CDKN1A MSH2 ITGB4 PDCD1 MDM2 TP53
7 integument MP:0010771 9.83 MSH2 ITGB4 MDM2 CDKN1A TP53
8 craniofacial MP:0005382 9.81 CDKN1A ITGB4 MDM2 TP53
9 liver/biliary system MP:0005370 9.71 MDM2 CDKN1A PDCD1 TP53
10 neoplasm MP:0002006 9.65 MSH2 PDCD1 MDM2 CDKN1A TP53
11 nervous system MP:0003631 9.63 MSH2 ITGB4 PDCD1 MDM2 CDKN1A TP53
12 muscle MP:0005369 9.62 MDM2 CDKN1A PDCD1 TP53
13 renal/urinary system MP:0005367 9.35 ITGB4 PDCD1 MDM2 CDKN1A TP53
14 respiratory system MP:0005388 8.92 CDKN1A ITGB4 PDCD1 TP53

Drugs & Therapeutics for Actinic Cheilitis

Drugs for Actinic Cheilitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aminolevulinic acid Approved Phase 4,Phase 1 106-60-5 137
2
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
3 interferons Phase 4
4 Methyl 5-aminolevulinate Phase 4,Phase 1
5 Adjuvants, Immunologic Phase 4
6 Dermatologic Agents Phase 4,Phase 1
7 Photosensitizing Agents Phase 4,Phase 1
8 Interferon Inducers Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment Study for Actinic Cheilitis Comparing Imiquimod 5% and Photodynamic Therapy Completed NCT00849992 Phase 4 Imiquimod 5%
2 Photodynamic Therapy to Treat Actinic Damage in Patients With Squamous Cell Carcinoma (SCC) of the Lip Completed NCT00868088 Phase 4
3 Photodynamic Therapy (PDT) With Levulan and Blue Light for the Treatment of Actinic Cheilitis Active, not recruiting NCT02409732 Phase 4 aminolevulinic acid hydrochloride
4 Evaluation of Ingenol Mebutate for Actinic Cheilitis Treatment Not yet recruiting NCT03452566 Phase 1, Phase 2 Ingenol mebutate gel
5 Study of Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Laser in Actinic Cheilitis Completed NCT02198469 Phase 1 Er:YAG AFL-PDT;MAL-PDT
6 Actinic Cheilitis Pre-Treated With DNA Repair Enzyme Cream Withdrawn NCT03224715 Not Applicable

Search NIH Clinical Center for Actinic Cheilitis

Genetic Tests for Actinic Cheilitis

Anatomical Context for Actinic Cheilitis

MalaCards organs/tissues related to Actinic Cheilitis:

41
T Cells, Salivary Gland

Publications for Actinic Cheilitis

Articles related to Actinic Cheilitis:

(show top 50) (show all 150)
# Title Authors Year
1
Prevalence of and Factors Associated with Actinic Cheilitis in Extractive Mining Workers. ( 29898071 )
2018
2
Surgical versus non-surgical treatment of actinic cheilitis: a systematic review and meta-analysis. ( 29908101 )
2018
3
Non-invasive imaging of actinic cheilitis and squamous cell carcinoma of the lip. ( 29725529 )
2018
4
Expression of cancer stem cell markers CD44, ALDH1 and p75NTR in actinic cheilitis and lip cancer. ( 29779037 )
2018
5
Expression of stem cell markers Nanog and Nestin in lip squamous cell carcinoma and actinic cheilitis. ( 29761881 )
2018
6
Erratum: Time-resolved fluorescence spectroscopy for clinical diagnosis of actinic cheilitis: erratum. ( 29552401 )
2018
7
Evaluation of Cellular Proliferative Activity in Patients with Actinic Cheilitis through Silver-stained Nucleolar Organizer Region Method. ( 29728540 )
2018
8
Immunoexpression of glucocorticoid receptor alpha (GRI+) isoform and apoptotic proteins (Bcl-2 and Bax) in actinic cheilitis and lower lip squamous cell carcinoma. ( 29935090 )
2018
9
Dermoscopy and reflectance confocal microscopy for monitoring the treatment of actinic cheilitis with ingenol mebutate gel: Report of three cases. ( 29687567 )
2018
10
Malignant transformation of actinic cheilitis: A systematic review of observational studies. ( 29863311 )
2018
11
Herpes simplex reactivation after photodynamic therapy for actinic cheilitis in a patient with Non-Hodgkin Lymphoma: a possible indication for prophylaxis. ( 29512976 )
2018
12
CD8+ and FoxP3+ T-cell infiltration in actinic cheilitis. ( 27778327 )
2017
13
5-aminolaevulinic acid patch-photodynamic therapy in the treatment of actinic cheilitis. ( 28703320 )
2017
14
Immunoexpression of HDAC1, HDAC2, and HAT1 in actinic cheilitis and lip squamous cell carcinoma. ( 28107582 )
2017
15
Actinic cheilitis: proposition and reproducibility of a clinical criterion. ( 29607086 )
2017
16
Diclofenac sodium gel therapy as an alternative to actinic cheilitis. ( 28986686 )
2017
17
Automated algorithm for actinic cheilitis diagnosis by wide-field fluorescence imaging. ( 27981067 )
2016
18
Immunohistochemical expression of DNA methyltransferases 1, 3a, and 3b in actinic cheilitis and lip squamous cell carcinomas. ( 27159259 )
2016
19
Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer. ( 26842232 )
2016
20
Histopathologic features in actinic cheilitis by the comparison of grading dysplasia systems. ( 27759902 )
2016
21
A comparative study using WHO and binary oral epithelial dysplasia grading systems in actinic cheilitis. ( 27029007 )
2016
22
Evaluation of hypoxia, angiogenesis, and lymphangiogenesis in actinic cheilitis. ( 27420649 )
2016
23
Evaluation of the efficacy of photodynamic therapy for the treatment of actinic cheilitis. ( 27864997 )
2016
24
Time-resolved fluorescence spectroscopy for clinical diagnosis of actinic cheilitis. ( 27867726 )
2016
25
Optical diagnosis of actinic cheilitis by infrared spectroscopy. ( 27491855 )
2016
26
Ingenol Mebutate for Recalcitrant Chronic Actinic Cheilitis. ( 27513668 )
2016
27
Link between immunoexpression of hMLH1 and hMSH2 proteins and clinical-epidemiological aspects of actinic cheilitis. ( 27579741 )
2016
28
Management of actinic cheilitis using ingenol mebutate gel: A report of seven cases. ( 27241280 )
2016
29
Value of videoroscopy in the detection of alterations of Actinic Cheilitis and the selection of biopsy areas. ( 25662549 )
2015
30
Clinicopathological profile and management of 161 cases of actinic cheilitis. ( 26375219 )
2015
31
Daylight photodynamic therapy with methyl-aminolevulinate for the treatment of actinic cheilitis. ( 26179312 )
2015
32
Treatment of actinic cheilitis with methyl aminolevulinate photodynamic therapy and light fractionation: a prospective study of 10 patients. ( 26677980 )
2015
33
Loss of cytokeratin 10 indicates malignant transformation in actinic cheilitis. ( 26264639 )
2015
34
Treatment of Actinic Cheilitis. ( 26418628 )
2015
35
Commentary on photodynamic therapy of actinic cheilitis. ( 25654194 )
2015
36
Ablative fractional laser assisted photodynamic therapy for the treatment of actinic cheilitis. ( 26174644 )
2015
37
Immunohistochemical expression of matrix metalloproteinase-1, matrix metalloproteinase-2 and matrix metalloproteinase-9, myofibroblasts and Ki-67 in actinic cheilitis and lip squamous cell carcinoma. ( 26515234 )
2015
38
Ingenol mebutate gel treatment for actinic cheilitis: report of four cases. ( 25545762 )
2015
39
Photodynamic therapy for actinic cheilitis: a systematic review. ( 25627629 )
2015
40
Pattern of galectins expression in actinic cheilitis with different risks of malignant transformation. ( 26711374 )
2015
41
Prevalence of and risk factors for actinic cheilitis in Brazilian fishermen and women. ( 25039599 )
2014
42
Efficacy of ablative fractional laser-assisted photodynamic therapy for the treatment of actinic cheilitis: 12-month follow-up results of a prospective, randomised, comparative trial. ( 25400009 )
2014
43
Dermoscopic features of plasma cell cheilitis and actinic cheilitis. ( 24474043 )
2014
44
Study of MDM2 and SUMO-1 expression in actinic cheilitis and lip cancer. ( 25241153 )
2014
45
Regulatory T cells in the actinic cheilitis. ( 25060152 )
2014
46
Expression of matrix metalloproteinases 9 and 12 in actinic cheilitis. ( 24520545 )
2013
47
Topical photodynamic therapy may not be effective for actinic cheilitis despite repeated treatments. ( 24201136 )
2013
48
Usefulness of tissue autofluorescence imaging in actinic cheilitis diagnosis. ( 23887482 )
2013
49
Erbium laser resurfacing for actinic cheilitis. ( 24196339 )
2013
50
Two cases of actinic cheilitis responsive to daylight-activated photodynamic therapy (DA-PDT). ( 24001384 )
2013

Variations for Actinic Cheilitis

Expression for Actinic Cheilitis

Search GEO for disease gene expression data for Actinic Cheilitis.

Pathways for Actinic Cheilitis

Pathways related to Actinic Cheilitis according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.17 CDKN1A ITGB4 MDM2 TP53
2
Show member pathways
12.76 CDKN1A ITGB4 MDM2 TP53
3
Show member pathways
12.75 CDKN1A MDM2 MSH2 TP53
4
Show member pathways
12.64 CDKN1A MDM2 MSH2 TP53
5
Show member pathways
12.6 CDKN1A MDM2 TP53
6 12.6 CDKN1A MDM2 MSH2 TP53
7
Show member pathways
12.57 CDKN1A MDM2 TP53
8
Show member pathways
12.53 CDKN1A MDM2 TP53
9
Show member pathways
12.45 CDKN1A MDM2 TP53
10
Show member pathways
12.42 CDKN1A MDM2 MSH2 TP53
11
Show member pathways
12.4 CDKN1A MSH2 TP53
12
Show member pathways
12.38 CDKN1A MDM2 TP53
13 12.33 CDKN1A MDM2 TP53
14
Show member pathways
12.3 CDKN1A MDM2 TP53
15
Show member pathways
12.21 CDKN1A MDM2 TP53
16 12.2 CDKN1A MDM2 TP53
17 12.18 CDKN1A MDM2 MSH2 TP53
18 12.13 CDKN1A MDM2 TP53
19 12.13 CDKN1A MDM2 TP53
20 12.13 CDKN1A MDM2 TP53
21
Show member pathways
12.09 CDKN1A MDM2 TP53
22 12.08 CDKN1A MDM2 TP53
23 12.01 CDKN1A MSH2 TP53
24 11.99 CDKN1A MDM2 TP53
25 11.97 MDM2 MSH2 TP53
26 11.88 CDKN1A MDM2 TP53
27 11.88 CDKN1A ITGB4 TP53
28
Show member pathways
11.84 CDKN1A MDM2 TP53
29 11.79 CDKN1A MDM2 TP53
30 11.78 CDKN1A ITGB4 MDM2 TP53
31 11.77 CDKN1A MDM2 TP53
32 11.73 CDKN1A MDM2 TP53
33
Show member pathways
11.65 MSH2 TP53
34 11.62 CDKN1A MDM2 TP53
35 11.59 CDKN1A ITGB4
36
Show member pathways
11.59 CDKN1A MDM2 TP53
37
Show member pathways
11.58 MDM2 TP53
38 11.58 CDKN1A MDM2 MSH2 TP53
39 11.55 CDKN1A MDM2 TP53
40 11.5 CDKN1A ITGB4
41 11.48 MDM2 TP53
42 11.47 CDKN1A MDM2 TP53
43 11.46 CDKN1A MDM2
44 11.44 MDM2 TP53
45 11.44 MDM2 TP53
46
Show member pathways
11.44 MDM2 TP53
47 11.41 CDKN1A TP53
48 11.41 CDKN1A TP53
49 11.39 CDKN1A TP53
50
Show member pathways
11.29 MSH2 TP53

GO Terms for Actinic Cheilitis

Cellular components related to Actinic Cheilitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear body GO:0016604 8.8 CDKN1A MDM2 TP53

Biological processes related to Actinic Cheilitis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.75 CDKN1A MSH2 TP53
2 negative regulation of apoptotic process GO:0043066 9.73 CDKN1A MDM2 PDCD1 TP53
3 Ras protein signal transduction GO:0007265 9.58 CDKN1A TP53
4 cell cycle arrest GO:0007050 9.58 CDKN1A MSH2 TP53
5 protein kinase B signaling GO:0043491 9.57 CDKN1A MDM2
6 cellular response to ionizing radiation GO:0071479 9.56 CDKN1A TP53
7 response to antibiotic GO:0046677 9.55 MDM2 TP53
8 intrinsic apoptotic signaling pathway GO:0097193 9.54 CDKN1A TP53
9 positive regulation of reactive oxygen species metabolic process GO:2000379 9.52 CDKN1A TP53
10 positive regulation of protein export from nucleus GO:0046827 9.51 MDM2 TP53
11 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.5 CDKN1A MDM2 TP53
12 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.49 CDKN1A TP53
13 replicative senescence GO:0090399 9.48 CDKN1A TP53
14 determination of adult lifespan GO:0008340 9.46 MSH2 TP53
15 signal transduction by p53 class mediator GO:0072331 9.37 CDKN1A TP53
16 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.33 CDKN1A MSH2 TP53
17 cellular response to actinomycin D GO:0072717 9.26 MDM2 TP53
18 cellular response to gamma radiation GO:0071480 9.13 CDKN1A MDM2 TP53
19 response to X-ray GO:0010165 8.8 CDKN1A MSH2 TP53

Molecular functions related to Actinic Cheilitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.5 CDKN1A MSH2 TP53
2 p53 binding GO:0002039 9.37 MDM2 TP53
3 enzyme binding GO:0019899 9.33 MDM2 MSH2 TP53
4 damaged DNA binding GO:0003684 9.26 MSH2 TP53
5 ubiquitin protein ligase binding GO:0031625 9.13 CDKN1A MDM2 TP53
6 disordered domain specific binding GO:0097718 8.62 MDM2 TP53

Sources for Actinic Cheilitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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