MCID: ACT093
MIFTS: 40

Actinic Cheilitis

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Actinic Cheilitis

MalaCards integrated aliases for Actinic Cheilitis:

Name: Actinic Cheilitis 52 71
Actinic Cheilosis 52

Classifications:



External Ids:

UMLS 71 C0267026

Summaries for Actinic Cheilitis

MalaCards based summary : Actinic Cheilitis, also known as actinic cheilosis, is related to basal cell carcinoma and lip cancer. An important gene associated with Actinic Cheilitis is TP53 (Tumor Protein P53), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Regulation of TP53 Activity. The drugs Aminolevulinic acid and Methyl 5-aminolevulinate have been mentioned in the context of this disorder. Affiliated tissues include skin, salivary gland and t cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 74 Actinic cheilitis is cheilitis (lip inflammation) caused by long term sunlight exposure. Essentially it... more...

Related Diseases for Actinic Cheilitis

Diseases related to Actinic Cheilitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 139)
# Related Disease Score Top Affiliating Genes
1 basal cell carcinoma 29.8 TP53 CDKN1A BCL2
2 lip cancer 29.8 TP53 MSH2 MDM2 CDKN1A
3 suppressor of tumorigenicity 3 29.7 TP53 CDKN1A BCL2
4 cheilitis 29.2 TP53 MSH2 MDM2 CDKN1A BCL2 APEX1
5 lymphoma, non-hodgkin, familial 29.0 TP53 MSH2 MDM2 BCL2
6 keratosis 10.6
7 actinic keratosis 10.6
8 squamous cell carcinoma 10.6
9 in situ carcinoma 10.2
10 ring chromosome 7 10.2 TP53 MDM2
11 ring chromosome 10.2 TP53 MDM2
12 esophagus verrucous carcinoma 10.2 TP53 MDM2
13 verrucous carcinoma 10.2 TP53 MDM2
14 periosteal osteogenic sarcoma 10.2 TP53 MDM2
15 maxillary sinus adenocarcinoma 10.2 TP53 MDM2
16 peripheral osteosarcoma 10.2 TP53 MDM2
17 parameningeal embryonal rhabdomyosarcoma 10.2 TP53 MDM2
18 embryonal rhabdomyosarcoma 10.2 TP53 MDM2
19 embryonal sarcoma 10.2 TP53 MDM2
20 adult astrocytic tumour 10.2 TP53 MDM2
21 malignant spiradenoma 10.2 TP53 MDM2
22 conventional fibrosarcoma 10.2 TP53 MDM2
23 uterine adnexa cancer 10.2 TP53 MDM2
24 familial retinoblastoma 10.2 TP53 MDM2
25 anal squamous cell carcinoma 10.1 TP53 MDM2
26 cataract 10.1
27 premature aging 10.1
28 neurofibromatosis, type ii 10.1
29 angular cheilitis 10.1
30 skin disease 10.1
31 superficial basal cell carcinoma 10.1
32 herpes simplex 10.1
33 albinism 10.1
34 leukoplakia 10.1
35 oral cancer 10.1
36 bladder transitional cell papilloma 10.1 TP53 CDKN1A
37 invasive bladder transitional cell carcinoma 10.1 TP53 CDKN1A
38 gliomatosis cerebri 10.1 TP53 MDM2
39 keratocystic odontogenic tumor 10.1 TP53 BCL2
40 bone osteosarcoma 10.1 TP53 MDM2
41 cardia cancer 10.1 TP53 MDM2
42 testicular torsion 10.1 TP53 BCL2
43 connective tissue benign neoplasm 10.1 TP53 MDM2
44 skin papilloma 10.1 TP53 CDKN1A
45 focal cortical dysplasia, type ii 10.1 TP53 BCL2
46 cervical adenoma malignum 10.0 TP53 MSH2
47 endometrioid ovary carcinoma 10.0 TP53 MSH2
48 well-differentiated liposarcoma 10.0 TP53 MDM2
49 extramedullary plasmacytoma 10.0 CDKN1A BCL2
50 endocervical adenocarcinoma 10.0 TP53 CDKN1A

Graphical network of the top 20 diseases related to Actinic Cheilitis:



Diseases related to Actinic Cheilitis

Symptoms & Phenotypes for Actinic Cheilitis

GenomeRNAi Phenotypes related to Actinic Cheilitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.17 CDKN1A
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.17 CDKN1A TP53
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.17 CDKN1A MDM2 MSH2 TP53

MGI Mouse Phenotypes related to Actinic Cheilitis:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.97 APEX1 BCL2 CDKN1A MDM2 MSH2 TP53
2 digestive/alimentary MP:0005381 9.85 BCL2 CDKN1A MDM2 MSH2 TP53
3 homeostasis/metabolism MP:0005376 9.85 APEX1 BCL2 CDKN1A MDM2 MSH2 TP53
4 embryo MP:0005380 9.83 APEX1 BCL2 CDKN1A MDM2 TP53
5 endocrine/exocrine gland MP:0005379 9.8 APEX1 BCL2 CDKN1A MDM2 TP53
6 immune system MP:0005387 9.8 APEX1 BCL2 CDKN1A MDM2 MSH2 TP53
7 craniofacial MP:0005382 9.78 BCL2 CDKN1A MDM2 TP53
8 integument MP:0010771 9.65 BCL2 CDKN1A MDM2 MSH2 TP53
9 muscle MP:0005369 9.55 APEX1 BCL2 CDKN1A MDM2 TP53
10 neoplasm MP:0002006 9.43 APEX1 BCL2 CDKN1A MDM2 MSH2 TP53
11 reproductive system MP:0005389 9.02 APEX1 BCL2 CDKN1A MDM2 TP53

Drugs & Therapeutics for Actinic Cheilitis

Drugs for Actinic Cheilitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aminolevulinic acid Approved Phase 4 106-60-5 137
2 Methyl 5-aminolevulinate Phase 4
3 Photosensitizing Agents Phase 4
4
Imiquimod Approved, Investigational Phase 2, Phase 3 99011-02-6 57469
5
Chitosan Experimental Phase 2, Phase 3 9012-76-4 71853
6 Adjuvants, Immunologic Phase 2, Phase 3
7 interferons Phase 2, Phase 3
8 Immunologic Factors Phase 2, Phase 3
9 Dermatologic Agents Phase 2, Phase 3
10 Sunscreening Agents Phase 2, Phase 3
11 Radiation-Protective Agents Phase 2, Phase 3
12 Protective Agents Phase 2, Phase 3
13
Lidocaine Approved, Vet_approved Phase 1 137-58-6 3676
14
Prilocaine Approved Phase 1 721-50-6 4906
15 Sodium Channel Blockers Phase 1
16 Anesthetics Phase 1
17 Anti-Arrhythmia Agents Phase 1
18 Lidocaine, Prilocaine Drug Combination Phase 1
19 Anesthetics, Local Phase 1
20 Diuretics, Potassium Sparing Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Prospective Study Comparing 5% Imiquimod and Photodynamic Therapy for Actinic Cheilitis Completed NCT00849992 Phase 4 Imiquimod 5%
2 Photodynamic Therapy (PDT) With Levulan and Blue Light for the Treatment of Actinic Cheilitis Completed NCT02409732 Phase 4 aminolevulinic acid hydrochloride
3 A Clinical Trial of ALA Photodynamic Therapy for Treatment of Actinic Cheilitis in Patients With Squamous Cell Carcinoma of the Lip. Completed NCT00868088 Phase 4
4 Evaluation of Topical Application of 5% Imiquimod, 0.05% Imiquimod and 0.05% Nanoencapsulated Imiquimod Gel in the Treatment of Actinic Cheilitis: a Randomized Controlled Trial Recruiting NCT04219358 Phase 2, Phase 3 Vehicle Gel Base;Imiquimod 5% gel;Imiquimod 0,05% gel;Imiquimod nanoencapsulated 0,05% gel;Lip sunscreen 30 Sun Protector Factor (SPF);Dexpanthenol
5 Photodynamic Therapy With Metil 5-aminolevulinate for Actinic Cheilitis - A Phase 2 Randomized Double-blind Placebo Controlled Clinical Trial Not yet recruiting NCT03990636 Phase 2 Metil 5-aminolevulinate
6 Phase 1/2 Clinical Trial for the Evaluation of Ingenol Mebutate for Actinic Cheilitis Withdrawn NCT03452566 Phase 1, Phase 2 Ingenol mebutate gel
7 A Randomized, Prospective Study Comparing Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Ablative Fractional Laser Treatment for Actinic Cheilitis Completed NCT02198469 Phase 1 Er:YAG AFL-PDT;MAL-PDT
8 A Randomised Trial Comparing Methyl Aminolaevulinate Photodynamic Therapy With and Without Ablative Fractional Laser Treatment in Patients With Microinvasive Squamous Cell Carcinoma: Results From a 24-month Follow-up Completed NCT02666534 Phase 1 lidocaine-prilocaine 5% cream application;methyl-aminolevulinate application
9 Efficacy of Iontophoresis-assisted Ablative Fractional Laser Photodynamic Therapy With Short Incubation Time for the Treatment of Actinic Keratosis: 12-month Follow-up Results of a Prospective, Randomised, Comparative Trial Completed NCT02670655 Phase 1 lidocaine/prilocaine (5%) application;MAL application
10 Actinic Cheilitis Pre-Treated With DNA Repair Enzyme Cream Withdrawn NCT03224715

Search NIH Clinical Center for Actinic Cheilitis

Genetic Tests for Actinic Cheilitis

Anatomical Context for Actinic Cheilitis

MalaCards organs/tissues related to Actinic Cheilitis:

40
Skin, Salivary Gland, T Cells, Kidney, Testes, Nk Cells

Publications for Actinic Cheilitis

Articles related to Actinic Cheilitis:

(show top 50) (show all 311)
# Title Authors PMID Year
1
Histopathological features of photodamage and mast cell infiltrate in actinic cheilitis with different grades of epithelial dysplasia. 61
32133685 2020
2
Vermilionectomy followed by reconstruction of the vermilion mucosa using allograft dermal matrix in patients with actinic cheilitis of the lower lip. 61
32396694 2020
3
A retrospective 11-year study on lip lesions attended at an oral diagnostic service. 61
32040463 2020
4
Clinical evaluation and efficacy of Imiquimod 3.75% cream for the treatment of actinic keratosis, pigmented basal cell carcinomas, and actinic cheilitis. 61
32239714 2020
5
Daylight photodynamic therapy for the management of actinic cheilitis. 61
32266532 2020
6
PI3K/AKT/mTOR pathway activation in actinic cheilitis and lip squamous cell carcinomas. 61
32255224 2020
7
Therapeutic approaches for actinic cheilitis: therapeutic efficacy and malignant transformation after treatment. 61
32171621 2020
8
Demographic and Clinicopathologic Features of Actinic Cheilitis and Lip Squamous Cell Carcinoma: a Brazilian Multicentre Study. 61
32077056 2020
9
Ingenol mebutate treatment for actinic cheilitis: clinical, histopathological and p53 profile of 14 cases. 61
32072836 2020
10
Oral potentially malignant disorders: clinical-pathological study of 684 cases diagnosed in a Brazilian population. 61
31880285 2020
11
5-Aminolevulinic acid patch (Alacare) photodynamic therapy for actinic cheilitis: data from a prospective 12-month follow-up study on 21 patients. 61
31999856 2020
12
Actinic cheilitis: Morphometric parameters and its relationship with the degree of epithelial dysplasia. 61
31558280 2020
13
Can immunohistochemical biomarkers distinguish epithelial dysplasia degrees in actinic cheilitis? A systematic review and meta-analysis. 61
31880283 2020
14
Detection of human papillomaviruses and human polyomaviruses in immunosuppressed and immunocompetent individuals with actinic cheilitis: a case series. 61
31281986 2019
15
Proper management of suspicious actinic cheilitis. 61
31032237 2019
16
Herpes simplex reactivation after photodynamic therapy for actinic cheilitis in a patient with non-Hodgkin lymphoma: a possible indication for prophylaxis. 61
29512976 2019
17
High rate of clinical improvement of actinic cheilitis with laser, surgery, and chemotherapeutic agents in patients who have a favorable prognosis. 61
31519297 2019
18
Patch Testing for Cheilitis: A 10-Year Series. 61
31609855 2019
19
Fludroxycortide cream as an alternative therapy for actinic cheilitis. 61
30673866 2019
20
[Potentially malignant disorders of the oral mucosa]. 61
32237647 2019
21
Actinic Cheilitis: Analysis of Clinical Subtypes, Risk Factors and Associated Signs of Actinic Damage. 61
31197386 2019
22
Treatments of actinic cheilitis: A systematic review of the literature. 61
31400450 2019
23
Use of lip photoprotection in patients suffering from actinic cheilitis. 61
31475909 2019
24
Immunoexpression of human leukocyte antigen-DR in actinic cheilitis and lower lip squamous cell carcinoma. 61
31483051 2019
25
DNA Repair Enzyme Containing Lip Balm for the Treatment of Actinic Cheilitis: A Pilot Study 61
31251551 2019
26
Surgical versus non-surgical treatment of actinic cheilitis: A systematic review and meta-analysis. 61
29908101 2019
27
Treatment of actinic cheilitis: a systematic review. 61
31011833 2019
28
Plasma cell cheilitis: the diagnosis of a disorder mimicking lip cancer. 61
30963053 2019
29
Ingenol mebutate versus imiquimod versus diclofenac for actinic cheilitis: a 6-month follow-up clinical study. 61
30242791 2019
30
Immune response and evasion mechanisms in lip carcinogenesis: An immunohistochemical study. 61
30468994 2019
31
Daylight photodynamic therapy for the treatment of actinic cheilitis. 61
30066408 2019
32
Evidence regarding how surgical treatment of actinic cheilitis compares with nonsurgical treatment is not trustworthy and does not consider all important outcomes. 61
30119827 2019
33
Actinic cheilitis and lip squamous cell carcinoma: Literature review and new data from Brazil. 61
30697396 2019
34
Actinic Cheilitis Prevalence and Risk Factors: A Cross-sectional, Multicentre Study in a Population Aged 45 Years and Over in North-west Spain. 61
30085328 2018
35
Malignant transformation of actinic cheilitis: A systematic review of observational studies. 61
29863311 2018
36
Expression of stem cell markers Nanog and Nestin in lip squamous cell carcinoma and actinic cheilitis. 61
29761881 2018
37
Daylight Photodynamic Therapy for Actinic Keratoses. 61
29752702 2018
38
Immunoexpression of glucocorticoid receptor alpha (GRα) isoform and apoptotic proteins (Bcl-2 and Bax) in actinic cheilitis and lower lip squamous cell carcinoma. 61
29935090 2018
39
Telediagnosis of oral lesions in primary care: The EstomatoNet Program. 61
29505701 2018
40
Prevalence of oral potentially malignant disorders: A systematic review and meta-analysis. 61
29738071 2018
41
Dermoscopy and reflectance confocal microscopy for monitoring the treatment of actinic cheilitis with ingenol mebutate gel: Report of three cases. 61
29687567 2018
42
Expression of cancer stem cell markers CD44, ALDH1 and p75NTR in actinic cheilitis and lip cancer. 61
29779037 2018
43
Association between oral mucosal lesions and crack and cocaine addiction in men: a cross-sectional study. 61
29736657 2018
44
Evaluation of specific modified histones in lip carcinogenesis. 61
29699903 2018
45
Differential Diagnosis of Cheilitis - How to Classify Cheilitis? 61
30431729 2018
46
Non-invasive imaging of actinic cheilitis and squamous cell carcinoma of the lip. 61
29725529 2018
47
Evaluation of epithelial dysplasia adjacent to lip squamous cell carcinoma indicates that the degree of dysplasia is not associated with the occurrence of invasive carcinoma in this site. 61
29740875 2018
48
Expression of E-cadherin, syndecan 1, Ki-67, and maintenance minichromosome 3 in tissue lesions of actinic prurigo obtained by incisional biopsy. 61
29676362 2018
49
Evaluation of Cellular Proliferative Activity in Patients with Actinic Cheilitis through Silver-stained Nucleolar Organizer Region Method. 61
29728540 2018
50
Diclofenac sodium gel therapy as an alternative to actinic cheilitis. 61
28986686 2018

Variations for Actinic Cheilitis

Cosmic variations for Actinic Cheilitis:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM122734401 upper aerodigestive tract,mouth,carcinoma,squamous cell carcinoma c.448C>T p.R150W 17:7673776-7673776 0

Expression for Actinic Cheilitis

Search GEO for disease gene expression data for Actinic Cheilitis.

Pathways for Actinic Cheilitis

Pathways related to Actinic Cheilitis according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.81 TP53 MDM2 CDKN1A BCL2
2
Show member pathways
12.8 TP53 MSH2 MDM2 CDKN1A
3
Show member pathways
12.77 TP53 MDM2 CDKN1A BCL2
4
Show member pathways
12.67 TP53 MDM2 CDKN1A BCL2
5
Show member pathways
12.65 TP53 MSH2 MDM2 CDKN1A BCL2
6 12.62 TP53 MSH2 MDM2 CDKN1A BCL2
7
Show member pathways
12.57 TP53 MDM2 CDKN1A BCL2
8
Show member pathways
12.55 TP53 MDM2 CDKN1A
9
Show member pathways
12.53 TP53 MDM2 CDKN1A BCL2
10
Show member pathways
12.47 TP53 MDM2 CDKN1A
11
Show member pathways
12.47 TP53 MDM2 CDKN1A BCL2
12
Show member pathways
12.43 TP53 MSH2 CDKN1A BCL2
13
Show member pathways
12.41 TP53 MDM2 CDKN1A
14
Show member pathways
12.41 TP53 MSH2 MDM2 CDKN1A BCL2 APEX1
15 12.38 TP53 MDM2 CDKN1A BCL2
16
Show member pathways
12.3 TP53 MDM2 BCL2
17 12.27 TP53 MSH2 MDM2 CDKN1A APEX1
18 12.26 TP53 MDM2 BCL2
19
Show member pathways
12.26 TP53 MDM2 CDKN1A
20 12.23 TP53 MDM2 CDKN1A
21
Show member pathways
12.23 TP53 MDM2 CDKN1A BCL2
22
Show member pathways
12.19 TP53 MDM2 CDKN1A
23 12.18 TP53 MDM2 CDKN1A
24 12.17 TP53 MDM2 CDKN1A
25 12.14 TP53 MDM2 CDKN1A
26
Show member pathways
12.09 TP53 MDM2 CDKN1A BCL2
27
Show member pathways
12.08 TP53 MDM2 CDKN1A BCL2
28 12.07 TP53 MSH2 CDKN1A
29 12.04 TP53 MDM2 CDKN1A
30 11.97 TP53 MSH2 MDM2 BCL2
31 11.89 TP53 CDKN1A BCL2
32 11.87 TP53 MDM2 CDKN1A
33 11.82 TP53 MDM2 CDKN1A BCL2
34 11.78 TP53 CDKN1A BCL2
35 11.78 TP53 MSH2 MDM2 CDKN1A BCL2
36 11.76 TP53 MDM2 CDKN1A BCL2
37 11.75 TP53 MDM2 CDKN1A
38
Show member pathways
11.74 TP53 MDM2 CDKN1A
39 11.71 TP53 MDM2 CDKN1A
40 11.64 TP53 MDM2 CDKN1A
41 11.52 CDKN1A BCL2
42 11.5 TP53 MDM2
43 11.5 TP53 MDM2 CDKN1A BCL2 APEX1
44 11.48 MDM2 CDKN1A
45 11.48 TP53 MDM2 APEX1
46
Show member pathways
11.46 TP53 MDM2
47 11.46 TP53 MDM2
48 11.45 TP53 CDKN1A BCL2
49 11.43 TP53 CDKN1A
50 11.42 TP53 CDKN1A

GO Terms for Actinic Cheilitis

Cellular components related to Actinic Cheilitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleolus GO:0005730 9.56 TP53 MDM2 CDKN1A APEX1
2 nuclear body GO:0016604 9.33 TP53 MDM2 CDKN1A
3 protein-containing complex GO:0032991 9.26 TP53 MDM2 CDKN1A BCL2
4 nucleoplasm GO:0005654 9.1 TP53 MSH2 MDM2 CDKN1A BCL2 APEX1

Biological processes related to Actinic Cheilitis according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.9 TP53 CDKN1A BCL2
2 negative regulation of gene expression GO:0010629 9.87 TP53 MDM2 CDKN1A
3 negative regulation of apoptotic process GO:0043066 9.87 TP53 MDM2 CDKN1A BCL2
4 cytokine-mediated signaling pathway GO:0019221 9.86 TP53 CDKN1A BCL2
5 regulation of apoptotic process GO:0042981 9.85 TP53 BCL2 APEX1
6 heart development GO:0007507 9.82 TP53 MDM2 CDKN1A
7 regulation of cell cycle GO:0051726 9.77 TP53 CDKN1A BCL2
8 cell cycle arrest GO:0007050 9.73 TP53 MSH2 CDKN1A
9 response to glucocorticoid GO:0051384 9.72 CDKN1A BCL2
10 double-strand break repair GO:0006302 9.72 TP53 MSH2
11 cellular response to hypoxia GO:0071456 9.72 TP53 MDM2 BCL2
12 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 9.71 CDKN1A BCL2
13 response to ischemia GO:0002931 9.71 TP53 BCL2
14 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.71 MSH2 BCL2
15 response to UV GO:0009411 9.71 TP53 CDKN1A
16 neuron apoptotic process GO:0051402 9.71 TP53 BCL2
17 negative regulation of cell growth GO:0030308 9.71 TP53 CDKN1A BCL2
18 cellular response to glucose starvation GO:0042149 9.7 TP53 BCL2
19 positive regulation of B cell proliferation GO:0030890 9.7 CDKN1A BCL2
20 positive regulation of intrinsic apoptotic signaling pathway GO:2001244 9.7 TP53 BCL2
21 negative regulation of mitotic cell cycle GO:0045930 9.69 TP53 BCL2
22 cellular response to organic substance GO:0071310 9.69 MDM2 BCL2
23 response to toxic substance GO:0009636 9.69 MDM2 CDKN1A BCL2
24 cellular response to ionizing radiation GO:0071479 9.68 TP53 CDKN1A
25 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 9.68 TP53 BCL2
26 T cell differentiation in thymus GO:0033077 9.68 TP53 BCL2
27 response to organonitrogen compound GO:0010243 9.68 CDKN1A APEX1
28 response to steroid hormone GO:0048545 9.67 MDM2 BCL2
29 intrinsic apoptotic signaling pathway GO:0097193 9.67 TP53 CDKN1A
30 positive regulation of reactive oxygen species metabolic process GO:2000379 9.66 TP53 CDKN1A
31 response to antibiotic GO:0046677 9.66 TP53 MDM2
32 cell aging GO:0007569 9.65 TP53 BCL2
33 response to gamma radiation GO:0010332 9.65 TP53 BCL2
34 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.64 TP53 BCL2
35 negative regulation of reactive oxygen species metabolic process GO:2000378 9.64 TP53 BCL2
36 release of cytochrome c from mitochondria GO:0001836 9.63 TP53 BCL2
37 cellular response to peptide hormone stimulus GO:0071375 9.63 MDM2 APEX1
38 positive regulation of protein export from nucleus GO:0046827 9.62 TP53 MDM2
39 response to iron ion GO:0010039 9.62 MDM2 BCL2
40 determination of adult lifespan GO:0008340 9.61 TP53 MSH2
41 mitotic cell cycle arrest GO:0071850 9.61 TP53 CDKN1A
42 cardiac septum morphogenesis GO:0060411 9.59 TP53 MDM2
43 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.58 TP53 CDKN1A
44 replicative senescence GO:0090399 9.58 TP53 CDKN1A
45 cellular response to DNA damage stimulus GO:0006974 9.55 TP53 MSH2 CDKN1A BCL2 APEX1
46 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.54 TP53 MDM2 CDKN1A
47 response to UV-B GO:0010224 9.52 MSH2 BCL2
48 cellular response to gamma radiation GO:0071480 9.5 TP53 MDM2 CDKN1A
49 cellular response to UV-C GO:0071494 9.49 TP53 MDM2
50 T cell lineage commitment GO:0002360 9.48 TP53 BCL2

Molecular functions related to Actinic Cheilitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.43 TP53 MSH2 MDM2
2 p53 binding GO:0002039 9.37 TP53 MDM2
3 damaged DNA binding GO:0003684 9.32 MSH2 APEX1
4 disordered domain specific binding GO:0097718 9.16 TP53 MDM2
5 protein phosphatase 2A binding GO:0051721 8.96 TP53 BCL2
6 ubiquitin protein ligase binding GO:0031625 8.92 TP53 MDM2 CDKN1A BCL2

Sources for Actinic Cheilitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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