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MCID: ACT008
MIFTS: 55

Actinic Keratosis

Categories: Cancer diseases, Genetic diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Actinic Keratosis

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MalaCards integrated aliases for Actinic Keratosis:

Name: Actinic Keratosis 12 77 56 15 17 74
Senile Hyperkeratosis 12
Seborrheic Keratosis 74
Sk - Solar Keratosis 12
Actinic Keratosis 12
Keratosis, Actinic 45
Solar Keratosis 12

Classifications:

MalaCards categories:
Global: Cancer diseases Genetic diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:8866
ICD9CM 36 702.0
MeSH 45 D055623
NCIt 51 C3148
SNOMED-CT 69 46795000 856006
ICD10 34 L57.0
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Summaries for Actinic Keratosis

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MalaCards based summary : Actinic Keratosis, also known as senile hyperkeratosis, is related to squamous cell carcinoma and bowen's disease. An important gene associated with Actinic Keratosis is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Mitotic G1-G1/S phases and MicroRNAs in cancer. The drugs Aminolevulinic acid and Imiquimod have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and kidney, and related phenotypes are growth/size/body region and behavior/neurological

Wikipedia : 77 Actinic keratosis (AK) is a pre-cancerous area of thick, scaly, or crusty skin. These growths are more... more...

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Related Diseases for Actinic Keratosis

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Diseases in the Actinic Keratosis family:

Keratosis, Familial Actinic

Diseases related to Actinic Keratosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 157)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 31.4 CDKN2A MMP2 PTGS2 TP53 TP63
2 bowen's disease 31.2 KRT17 PCNA
3 basal cell carcinoma 30.9 KRT17 KRT20 MC1R TP53
4 in situ carcinoma 30.8 CDKN2A KRT17 TP53
5 keratoacanthoma 30.3 FLG KRT17 TP53
6 papilloma 29.5 CDKN2A FLG KRT20 PCNA TP53 TP63
7 keratosis 11.9
8 actinic cheilitis 11.3
9 basal cell carcinoma 1 10.7
10 skin carcinoma 10.6
11 melanoma 10.5
12 vulvar intraepithelial neoplasia 10.4 MMP2 TP53
13 bladder squamous cell carcinoma 10.4 CDKN2A TP53
14 protoplasmic astrocytoma 10.4 PTGS2 TP53
15 keratinizing squamous cell carcinoma 10.4 CDKN2A TP53
16 spitz nevus 10.4 CDKN2A TP53
17 recurrent respiratory papillomatosis 10.4 PTGS2 TP53
18 multicentric osteolysis, nodulosis, and arthropathy 10.4 MMP14 MMP2
19 winchester syndrome 10.4 MMP14 MMP2
20 bizarre leiomyoma 10.4 CDKN2A PCNA
21 bladder carcinoma in situ 10.4 CDKN2A TP53
22 scrotal carcinoma 10.4 CDKN2A TP53
23 colloid adenoma 10.4 KRT20 TP53
24 thyroid lymphoma 10.4 CDKN2A TP53
25 arteriovenous fistula 10.4 MMP2 PCNA
26 vulvar disease 10.4 CDKN2A TP53
27 fibroepithelial basal cell carcinoma 10.4 KRT20 TP53
28 nasal cavity adenocarcinoma 10.3 CDKN2A TP53
29 bladder papillary transitional cell neoplasm 10.3 KRT20 TP53
30 ameloblastic carcinoma 10.3 CDKN2A TP63
31 lentigines 10.3
32 urinary tract papillary transitional cell benign neoplasm 10.3 KRT20 TP53
33 bartholin's gland disease 10.3 CDKN2A TP53
34 tongue disease 10.3 CDKN2A MMP2 TP53
35 laryngeal disease 10.3 CDKN2A MMP2 TP53
36 cystic basal cell carcinoma 10.3 KRT20 TP63
37 supratentorial cancer 10.3 CDKN2A MMP2 TP53
38 cerebrum cancer 10.3 CDKN2A MMP2 TP53
39 vulval paget's disease 10.3 CDKN2A KRT20
40 barrett's adenocarcinoma 10.3 CDKN2A PTGS2 TP53
41 juvenile pilocytic astrocytoma 10.3 CDKN2A TNC TP53
42 esophageal disease 10.3 CDKN2A PTGS2 TP53
43 tongue cancer 10.3 CDKN2A MMP2 TP53
44 bile duct adenoma 10.3 CDKN2A KRT20
45 female reproductive system disease 10.3 CDKN2A MMP2 TP53
46 respiratory system cancer 10.3 CDKN2A MMP2 TP53
47 tongue squamous cell carcinoma 10.3 CDKN2A MMP2 TP53
48 suppressor of tumorigenicity 3 10.3 CDKN2A PCNA TP53
49 lentigo maligna melanoma 10.3 MC1R MMP2
50 endocrine gland cancer 10.3 CDKN2A MMP2 TP53

Graphical network of the top 20 diseases related to Actinic Keratosis:



Diseases related to Actinic Keratosis
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Symptoms & Phenotypes for Actinic Keratosis

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MGI Mouse Phenotypes related to Actinic Keratosis:

47 (show all 22)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.33 CDKN2A KRT17 LUM MC1R MCM2 MMP14
2 behavior/neurological MP:0005386 10.3 CDKN2A LUM MC1R MCM2 MMP14 PTGS2
3 cellular MP:0005384 10.29 CDKN2A KRT17 LUM MC1R MCM2 MMP14
4 immune system MP:0005387 10.26 CDKN2A LUM MC1R MCM2 MMP14 MMP2
5 mortality/aging MP:0010768 10.22 CDKN2A KRT17 LUM MCM2 MMP14 MMP2
6 integument MP:0010771 10.21 CDKN2A KRT17 LUM MC1R MCM2 MMP14
7 cardiovascular system MP:0005385 10.2 CDKN2A LUM MMP14 MMP2 PTGS2 TP53
8 hematopoietic system MP:0005397 10.19 CDKN2A LUM MC1R MCM2 MMP14 MMP2
9 digestive/alimentary MP:0005381 10.18 CDKN2A KRT17 LUM MCM2 MMP14 PTGS2
10 endocrine/exocrine gland MP:0005379 10.16 CDKN2A MCM2 MMP14 PCNA PTGS2 TP53
11 craniofacial MP:0005382 10.13 KRT17 MC1R MMP14 MMP2 TP53 TP63
12 embryo MP:0005380 10.11 CDKN2A MCM2 MMP14 PTGS2 TP53 TP63
13 no phenotypic analysis MP:0003012 10.1 CDKN2A KRT17 MC1R MMP14 PCNA PTGS2
14 muscle MP:0005369 10.06 CDKN2A LUM MCM2 MMP14 MMP2 PTGS2
15 neoplasm MP:0002006 10.03 CDKN2A MC1R MCM2 MMP2 PTGS2 TP53
16 limbs/digits/tail MP:0005371 9.97 LUM MC1R MMP14 TP53 TP63 TYR
17 normal MP:0002873 9.97 MCM2 MMP14 MMP2 PTGS2 TNC TP53
18 reproductive system MP:0005389 9.86 CDKN2A LUM MMP14 PCNA PTGS2 TP53
19 pigmentation MP:0001186 9.8 CDKN2A KRT17 MC1R MCM2 TP53 TYR
20 respiratory system MP:0005388 9.7 CDKN2A MCM2 MMP14 MMP2 PTGS2 TP53
21 skeleton MP:0005390 9.56 CDKN2A LUM MMP14 MMP2 PTGS2 TP53
22 vision/eye MP:0005391 9.23 CDKN2A LUM MMP14 MMP2 PTGS2 TP53
Sources

Drugs & Therapeutics for Actinic Keratosis

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Drugs for Actinic Keratosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 216)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aminolevulinic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 106-60-5 137
2
Imiquimod Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 99011-02-6 57469
3
Fluorouracil Approved Phase 4,Phase 3,Early Phase 1,Not Applicable 51-21-8 3385
4
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
5
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 15307-86-5 3033
6
Lidocaine Approved, Vet_approved Phase 4,Phase 1,Not Applicable 137-58-6 3676
7
Prilocaine Approved Phase 4,Phase 1 721-50-6 4906
8
Polymyxin B Approved, Vet_approved Phase 4 1404-26-8
9
Mineral oil Approved, Vet_approved Phase 4 8042-47-5
10
Bacitracin Approved, Vet_approved Phase 4 1405-87-4 10909430 439542
11
Hydrogen peroxide Approved, Vet_approved Phase 4,Phase 2 7722-84-1 784
12
Ethanol Approved Phase 4,Phase 2,Not Applicable 64-17-5 702
13
Bezafibrate Approved, Investigational Phase 4 41859-67-0 39042
14
Petrolatum Approved, Investigational Phase 4,Phase 2,Early Phase 1,Not Applicable 8009-03-8
15
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
16
Salicylic acid Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 69-72-7 338
17
Tacrolimus Approved, Investigational Phase 4,Phase 1,Phase 2 104987-11-3 6473866 445643 439492
18
Menthol Approved Phase 4 2216-51-5 16666
19
Everolimus Approved Phase 4,Phase 1,Phase 2 159351-69-6 70789204 6442177
20
Sirolimus Approved, Investigational Phase 4,Phase 1,Phase 2 53123-88-9 46835353 5284616 6436030
21
Azathioprine Approved Phase 4 446-86-6 2265
22
Mycophenolic acid Approved Phase 4 24280-93-1 446541
23
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 68-26-8, 22737-96-8, 11103-57-4 9904001 445354
24
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Not Applicable 1406-16-2
25
Calcium Approved, Nutraceutical Phase 4,Phase 1,Early Phase 1,Not Applicable 7440-70-2 271
26
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
27
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 1 50-14-6 5280793
28
Protoporphyrin IX Experimental Phase 4,Phase 1 553-12-8
29 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
30 Methyl 5-aminolevulinate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
31 Photosensitizing Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
32 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
33 interferons Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
34 Adjuvants, Immunologic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
35 Interferon Inducers Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Radiation-Protective Agents Phase 4,Phase 2
37 Protective Agents Phase 4,Phase 3,Phase 2,Not Applicable
38 Sunscreening Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
39 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
40 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Anti-Infective Agents, Local Phase 4,Phase 2,Not Applicable
42 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
43 Antimetabolites, Antineoplastic Phase 4,Phase 3,Early Phase 1,Not Applicable
44 Antimetabolites Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
45 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
46 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
47 Nutrients Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
48 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable
49 Vitamins Phase 4,Phase 2,Phase 1,Early Phase 1,Not Applicable
50 Keratolytic Agents Phase 4,Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 376)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Treatment of Actinic Keratoses With Photodynamic Therapy Between MAL Cream and ALA Gel Unknown status NCT02647151 Phase 4 METHYLAMINOLEVULINATE HYDROCHLORIDE;AMINOLEVULINIC ACID HYDROCHLORIDE
2 Imiquimod 3.75% Cream in Combination With Cryotherapy in the Treatment of Hypertrophic Actinic Keratoses Unknown status NCT01229319 Phase 4 Cryotherapy alone to Left arm plus cryotherapy + imiquimod to Right arm;Cryotherapy alone to Left arm plus cryotherapy + imiquimod to Right arm
3 Long Term Efficacy and Safety of Eryfotona AK-NMSC® in Patients With Actinic Keratosis Unknown status NCT01656226 Phase 4
4 Potential Effect of Topical Imiquimod on Atrial Ectopy in Patients With Actinic Keratosis Unknown status NCT01413763 Phase 4 Imiquimod cream 3.75%;Placebo cream
5 Daylight PDT for Actinic Keratoses: a Multicentre Study Comparing Two Photosensitizers (BF-200 ALA Versus MAL) Completed NCT02464709 Phase 4 Aminolevulinic Acid;Methyl 5-aminolevulinate
6 Study of Daylight Photodynamic Therapy With Aminolevulinic Acid for Actinic Keratoses Completed NCT03327831 Phase 4 Aminolevulinic Acid
7 Evaluate the Efficacy and Safety of Large-Scale Field-Directed Topical Therapy of Actinic Keratosis of the Chest w/Ingenol Mebutate 0.015% Completed NCT02446223 Phase 4 Inggenol Mebutate 0.015%
8 Topical Imiquimod Cream in Combination With Cryotherapy for the Treatment of Actinic Keratoses Completed NCT00774787 Phase 4 imiquimod 5% cream
9 Effects of Topical Diclofenac on Tumor Metabolism Completed NCT01935531 Phase 4 3% diclofenac in 2.5% hyaluronic acid gel
10 Clinical Trial of Ingenol Mebutate Gel 0.015% & 0.05% in Actinic Keratosis Completed NCT02716714 Phase 4 ingenol mebutate gel 0.015%;ingenol mebutate gel 0.05%
11 Efficacy of Ablative Fractional Laser-assisted Photodynamic Therapy According to the Laser Density for Actinic Keratosis Completed NCT03731988 Phase 4 lidocaine/prilocaine (5%) application;MAL application
12 Open-Label Safety Study to Evaluate Imiquimod Cream, 5% for Large Areas of Actinic Keratosis Completed NCT00116649 Phase 4 imiquimod cream
13 Safety and Efficacy of Ingenol Mebutate Gel 0.015% for Treatment of AK on the Face in Solid Organ Transplant Recipients Completed NCT02866695 Phase 4 ingenol mebutate gel 0.015%
14 Gene Expression in Renal Transplant Patients With Field Actinic Keratosis Undergoing Metvix® Photodynamic Therapy (PDT) Completed NCT01000636 Phase 4
15 Safety and Efficacy of Ingenol Mebutate 0.05% Gel When Used After Cryotherapy in the Hypertrophic Actinic Keratoses Completed NCT02251652 Phase 4 Ingenol Mebutate
16 Long-term Effects of Imiquimod and Diclofenac in Actinic Keratoses (LEIDA 2) Completed NCT01453179 Phase 4 Imiquimod;Diclofenac
17 Long-term Effects of Imiquimod and Diclofenac in Actinic Keratoses Completed NCT00777127 Phase 4 Imiquimod;Diclofenac
18 Bilateral Comparison of Treatment of Facial Actinic Keratoses Using Microneedling and Photodynamic Therapy With Aminolevulinic Acid and Blue Light Versus Photodynamic Therapy With Aminolevulinic Acid and Blue Light Using Two Incubation Times Completed NCT02622594 Phase 4 Aminolevulinic Acid (ALA)
19 Study of Imiquimod 5% Cream in Addition to Cryotherapy in the Management of Actinic Keratoses Completed NCT00110682 Phase 4 Imiquimod used as an adjunct to cryotherapy
20 Clinical Trial to Evaluate Biafine Cream Versus Standard Care in Subjects With Actinic Keratosis Post Cryotherapy Completed NCT00695578 Phase 4 Biafine;Polysporin
21 An Open-Label 18-Month Safety Study of Fluorouracil Cream 0.5% for the Treatment of Actinic Keratoses Completed NCT00377273 Phase 4 fluorouracil cream 0.5%
22 Photodynamic Therapy of Actinic Keratosis of the Face and Scalp With and Without Prior Curettage Completed NCT03697590 Phase 4 No curettage;Curettage
23 Comparison of the Efficacy and Tolerability of Solaraze for 3 Versus 6 Months in Patients With Mild to Moderate Actinic Keratosis Located on the Face and Head Completed NCT00204542 Phase 4 Diclofenac;Diclofenac
24 Study to Assess the Safety and Efficacy of Imiquimod 5% Cream for the Treatment of Actinic Keratosis on the Arms and Hands Completed NCT00115154 Phase 4 Aldara (imiquimod) cream, 5%
25 Efficacy and Safety of Ingenol Mebutate Gel 0.015% Compared to Diclofenac Sodium Gel 3% in Subjects With Actinic Keratoses on the Face or Scalp Completed NCT02406014 Phase 4 Ingenol Mebutate Gel, 0.015%;Diclofenac sodium gel 3%
26 Measuring Adherence To Topical 5-Fluorouracil in a Clinic Population Completed NCT00696488 Phase 4 Fluorouracil 0.5%
27 An A Study Assessing Subject Satisfaction With A-101 Topical Solution for Seborrheic Keratoses Completed NCT03487588 Phase 4 A-101 Topical Solution
28 PRO With Luxerm® in the Field Treatment of Thin and Non-hyperkeratotic Non-pigmented AK Completed NCT03511326 Phase 4 Methyl Aminolaevulinate 16% Cream
29 Daylight-PDT for AKs: Comparing Two Photosensitizers (BF-200 ALA and MAL) Completed NCT01893203 Phase 4 BF-200 ALA cream;MAL cream
30 Zurich Multiple Endpoint Vitamin D Trial in Knee OA Patients Completed NCT00599807 Phase 4
31 The Effect of Fibrate Therapy in Two Patients With Neutral Lipid Storage Disease With Myopathy (NLSDM) Completed NCT01527318 Phase 4 Fibrate treatment
32 Aminolevulinic Acid-photodynamic Therapy for Facial Actinic Keratosis Treatment and Prevention Recruiting NCT03642535 Phase 4 ALA
33 Evaluating Skin Appearance Following 5-Flourouracil Cream for Treatment of Actinic Keratosis and the Effects of Topical Agents Recruiting NCT03279328 Phase 4 Topical Steroid Ointment;Skin Barrier Moisturier
34 Menthol for PDT Pain Relief Recruiting NCT02984072 Phase 4 Menthol;Aqueous Cream
35 Treatment of Photodamaged Skin of the décolleté Recruiting NCT03573076 Phase 4
36 Efficacy of Ingenol Mebutate on Actinic Keratoses and Field Cancerization vs Cryotherapy Active, not recruiting NCT02990221 Phase 4 Ingenol mebutate
37 IM Versus 5-FU Versus IMI Versus MAL-PDT in Treatment of Actinic Keratosis Active, not recruiting NCT02281682 Phase 4 Imiquimod;5-fluorouracil;Ingenol mebutate
38 Daylight-PDT With MAL for AK and Photodamaged Skin Active, not recruiting NCT02736760 Phase 4 Daylight photodynamic therapy using Methylaminolevulinate (MAL)
39 Risk of Squamous Cell Carcinoma on Skin Areas Treated With Ingenol Mebutate Gel, 0.015% and Imiquimod Cream, 5% Active, not recruiting NCT01926496 Phase 4 Ingenol Mebutate Gel, 0.015%;Imiquimod Cream, 5%
40 Imiquimod Versus Photodynamic Therapy of Actinic Keratoses in Organ Transplant Recipients Terminated NCT01538901 Phase 4 imiquimod 5% cream
41 Treatment of Actinic Keratoses of the Face With Imiquimod 3.75% Cream Followed by Photodynamic Therapy Terminated NCT01203878 Phase 4 Photodynamic therapy;Imiquimod
42 Efficacy and Safety of Salkera Emollient Foam in the Treatment of Moderate to Severe Keratosis Pilaris, a Prospective Study Terminated NCT00944216 Phase 4 Salkera Emollient Foam
43 Prevention of Skin Cancer in High Risk Patients After Conversion to a Sirolimus-based Immunosuppressive Protocol Terminated NCT00866684 Phase 4 Sirolimus;Azathioprine;Mycophenolate;Ciclosporin;Tacrolimus
44 Prevention of Skin Cancer in High Risk Patients After Conversion to a Sirolimus-based Immunosuppressive Protocol Terminated NCT01797315 Phase 4 Sirolimus
45 T4N5 Liposome Lotion Compared With Placebo Lotion for Preventing Actinic Keratoses in Patients With Xeroderma Pigmentosum Unknown status NCT00002811 Phase 3 liposomal T4N5 lotion
46 5fluorouracil for Advanced Photoaging Unknown status NCT01405144 Phase 3 5-fluoruracil
47 Treatment of the Recessive Nonbullous Congenital Ichthyosis by the Epigallocatechine Cutaneous Unknown status NCT01222000 Phase 3 apply VEREGEN ® 10 % on a randomized area and the moisturizing cream of the other side;apply VEREGEN ® 10 % on a randomized area and the moisturizing cream of the other side
48 A Multicenter Study to Evaluate the Efficacy and Safety of PEP005 (Ingenol Mebutate) Gel When Used to Treat Actinic Keratoses (AKs) on the Non Head Locations Completed NCT00942604 Phase 3 PEP005 (ingenol mebutate) Gel;Vehicle gel
49 A Multicenter Study to Evaluate the Efficacy and Safety of PEP005 (Ingenol Mebutate) Gel When Used to Treat Actinic Keratoses (AKs) on the Non Head Locations Completed NCT00742391 Phase 3 PEP005 (ingenol mebutate) Gel;Vehicle gel
50 Study To Evaluate The Efficacy And Safety Of Actikerall® Solution In Patients With Grade I-II Actinic Keratoses Completed NCT02289768 Phase 3 5-fluorouracil/salicylic acid;Vehicle

Search NIH Clinical Center for Actinic Keratosis

Cochrane evidence based reviews: keratosis, actinic

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Genetic Tests for Actinic Keratosis

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Anatomical Context for Actinic Keratosis

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MalaCards organs/tissues related to Actinic Keratosis:

42
Skin, Testes, Kidney, Lung, Bone, Tongue, T Cells
Sources

Publications for Actinic Keratosis

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Articles related to Actinic Keratosis:

(show top 50) (show all 897)
# Title Authors Year
1
Insight into the management of actinic keratosis: a qualitative interview study among general practitioners and dermatologists. ( 30801664 )
2019
2
Monitoring sequential treatment of actinic keratosis using post-processed images: Ingenol mebutate and cryosurgery. ( 30815968 )
2019
3
Reducing Unpleasant Side Effects of Topical 5-Flourouracil Treatment for Actinic Keratosis: A Randomized Controlled Trial. ( 30821548 )
2019
4
Comprehensive analysis of β and γ Human Papillomaviruses in actinic keratosis and apparently healthy skin of elderly patients. ( 30825192 )
2019
5
Daylight photodynamic therapy for severe facial and scalp actinic keratosis: a prospective non-sponsored single-centre study employing the actinic keratosis area and severity index (AKASI). ( 30827943 )
2019
6
Efficacy of topical Imiquimod 3.75% in the treatment of Actinic Keratosis of the scalp in immunosuppressed patients: our case series. ( 30836026 )
2019
7
What is the most relevent factor during ALA-PDT？ A multi-center, open clinical pain score research about actinic keratosis, acne and condylomatata acuminata. ( 30836211 )
2019
8
A randomized, double-blind trial comparing 5-aminolevulinic acid nanoemulsion (BF-200 ALA) with methyl-5-aminolevulinate (MAL) in daylight photodynamic therapy for actinic keratosis. ( 30845350 )
2019
9
Randomized Trial of Four Treatment Approaches for Actinic Keratosis. ( 30855743 )
2019
10
Split face study comparing conventional mal photodynamic therapy in multiple actinic keratosis with complete time versus half-time red light led conventional illumination. ( 30868672 )
2019
11
Geographic variability of pricing and insurance coverage of topical actinic keratosis therapy - a survey-based study. ( 30910661 )
2019
12
A discrete-choice experiment and actinic keratosis: what is the answer? ( 30933330 )
2019
13
From actinic keratosis to squamous cell carcinoma - answers to some open questions. ( 30933346 )
2019
14
5-fluorouracil-induced erythema and transepidermal water loss associated with complete actinic keratosis resolution. ( 30942937 )
2019
15
Disruption of latent HIV in vivo during the clearance of actinic keratosis by ingenol mebutate. ( 30944245 )
2019
16
Review of Clinical Evidence over 10 Years on Prevention and Treatment of a Film-Forming Medical Device Containing Photolyase in the Management of Field Cancerization in Actinic Keratosis. ( 30968311 )
2019
17
Low-irradiance red light compared to conventional red light in photodynamic therapy of actinic keratosis: A way to reduce pain during treatment. ( 30968530 )
2019
18
5-aminolevulinic acid photodynamic therapy with and without Er:YAG laser for actinic keratosis: changes in immune infiltration. ( 30986538 )
2019
19
Prevalence, Discontinuation Rate, and Risk Factors for Severe Local Site Reactions with Topical Field Treatment Options for Actinic Keratosis of the Face and Scalp. ( 30987411 )
2019
20
Safety and Efficacy of Aminolevulinic Acid 10% Topical Gel versus Aminolevulinic Acid 20% Topical Solution Followed by Blue-light Photodynamic Therapy for the Treatment of Actinic Keratosis on the Face and Scalp: A Randomized, Double-blind Study. ( 30988871 )
2019
21
The conventional protocol versus a protocol including illumination with a fabric-based biophotonic device (the Phosistos protocol) in photodynamic therapy for actinic keratosis: a randomized, controlled, non-inferiority clinical study. ( 31021404 )
2019
22
Conceptual, statistical and clinical interpretation of results from: Cryosurgery combined with topical interventions for actinic keratosis: reply from the authors. ( 31021410 )
2019
23
Evaluating the Noninferiority of a New Photodynamic Therapy (Flexitheralight) Compared With Conventional Treatment for Actinic Keratosis: Protocol for a Phase 2 Study. ( 31025952 )
2019
24
A New Light-Emitting, Fabric-Based Device for Photodynamic Therapy of Actinic Keratosis: Protocol for a Randomized, Controlled, Multicenter, Intra-Individual, Phase II Noninferiority Study (the Phosistos Study). ( 31025953 )
2019
25
T-Cadherin Expression in Actinic Keratosis Transforming to Invasive Squamous Cell Carcinoma. ( 31049318 )
2019
26
Diclofenac-Derived Hybrids for Treatment of Actinic Keratosis and Squamous Cell Carcinoma. ( 31075867 )
2019
27
Photodynamic therapy for actinic keratosis in vegan and omnivore patients: the role of diet on skin healing. ( 31076007 )
2019
28
Correlations between histopathologic and dermoscopic findings in Korean actinic keratosis. ( 29676831 )
2019
29
Physician-patient communication and patient-reported outcomes in the actinic keratosis treatment adherence initiative (AK-TRAIN): a multicenter, prospective, real-life study of treatment satisfaction, quality of life and adherence to topical field-directed therapy for the treatment of actinic keratosis in Italy. ( 29920789 )
2019
30
A randomized, intraindividual, non-inferiority, Phase III study comparing daylight photodynamic therapy with BF-200 ALA gel and MAL cream for the treatment of actinic keratosis. ( 30022544 )
2019
31
Long-term sheltering mustaches reduce incidence of lower lip actinic keratosis. ( 30031144 )
2019
32
Actinic keratosis - review for clinical practice. ( 30070357 )
2019
33
Efficacy and safety of daylight photodynamic therapy after tailored pretreatment with ablative fractional laser or microdermabrasion: a randomized, side-by-side, single-blind trial in patients with actinic keratosis and large-area field cancerization. ( 30117140 )
2019
34
Local interventions for actinic keratosis in organ transplant recipients: a systematic review. ( 30188570 )
2019
35
Laser-assisted photodynamic therapy for actinic keratosis: A systematic review and meta-analysis. ( 30267719 )
2019
36
Evaluation of the treatment costs and duration of topical treatments for multiple actinic keratosis based on the area of the cancerization field and not on the number of lesions. ( 30288788 )
2019
37
Full face ingenol mebutate for actinic keratosis: patient perspective. ( 30302750 )
2019
38
Conjunctival actinic keratosis. ( 30314825 )
2019
39
Monitoring treatment response in patients affected by actinic keratosis: Dermoscopic assessment and metalloproteinases evaluation after piroxicam 0.8% and sunfilter cream. ( 30318747 )
2019
40
Dynamic thermal imaging on actinic keratosis patients: A preliminary study. ( 30357926 )
2019
41
Daylight versus conventional photodynamic therapy for the treatment of actinic keratosis: A meta-analysis of randomized controlled trials. ( 30412779 )
2019
42
Comparative effectiveness of treatment of actinic keratosis with topical fluorouracil and imiquimod in the prevention of keratinocyte carcinoma: A cohort study. ( 30458208 )
2019
43
Low-level light-assisted photodynamic therapy using a wearable cap-like device for the treatment of actinic keratosis of the scalp. ( 30508663 )
2019
44
Actinic keratosis and imiquimod: a review of novel carriers and patents. ( 30582385 )
2019
45
'Surprisingly little evidence' on how best to treat actinic keratosis in organ transplant recipients. ( 30604541 )
2019
46
Occurrence of newly discovered human polyomaviruses in skin of liver transplant recipients and their relation with squamous cell carcinoma in situ and actinic keratosis - a single-center cohort study. ( 30632206 )
2019
47
Methyl aminolevulinate daylight photodynamic therapy applied at home for non-hyperkeratotic actinic keratosis of the face or scalp: an open, interventional study conducted in Germany. ( 30633376 )
2019
48
Healthcare utilization and management of actinic keratosis in primary and secondary care: a complementary database analysis. ( 30636037 )
2019
49
Relative efficacy of 5-fluorouracil compared with other treatments among patients with actinic keratosis: A network meta-analysis. ( 30638294 )
2019
50
Non-invasive monitoring of subclinical and clinical actinic keratosis of face and scalp under topical treatment with ingenolmebutate gel 150 mcg/gby means of reflectance confocal microscopy and optical coherence tomography: new perspectives and comparison of diagnostic techniques. ( 30653833 )
2019
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Variations for Actinic Keratosis

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Expression for Actinic Keratosis

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Search GEO for disease gene expression data for Actinic Keratosis.
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Pathways for Actinic Keratosis

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Pathways related to Actinic Keratosis according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Mitotic G1-G1/S phases 67
Show member pathways
 12.31 CDKN2A MCM2 PCNA TP53
2
MicroRNAs in cancer 38
12.13 CDKN2A PTGS2 TNC TP53 TP63
3
Cell cycle 38 1
12.09 CDKN2A MCM2 PCNA TP53
4
DNA Damage 4
12.02 CDKN2A MCM2 PCNA TP53 TP63
5
Colorectal Cancer Metastasis 65
11.89 MMP14 MMP2 PTGS2 TP53
6
Interleukin-4 and 13 signaling 67
11.74 MMP2 PTGS2 TP53
7
Direct p53 effectors 1
11.74 MMP2 PCNA TP53 TP63
8
Angiogenesis (CST) 4
11.6 MMP2 PTGS2 TNC
9
Bladder cancer 1 38
11.5 CDKN2A MMP2 TP53
10
Photodynamic therapy-induced AP-1 survival signaling. 1
11.29 CDKN2A MMP2 TP53
11
Senescence and Autophagy in Cancer 1
11.28 CDKN2A MMP14 PCNA TP53
12
Inhibition of Ribosome Biogenesis by p14(ARF) 65
10.87 CDKN2A TP53
13
TP53 Network 1
Show member pathways
 10.14 CDKN2A TP53 TP63
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GO Terms for Actinic Keratosis

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Cellular components related to Actinic Keratosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.26 LUM MMP14 MMP2 TNC
2 collagen-containing extracellular matrix GO:0062023 8.92 FLG LUM MMP2 TNC

Biological processes related to Actinic Keratosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.8 PCNA TP53 TP63 TYR
2 apoptotic process GO:0006915 9.72 CDKN2A KRT20 MCM2 TP53 TP63
3 response to organic cyclic compound GO:0014070 9.61 LUM MMP14 PTGS2
4 response to oxidative stress GO:0006979 9.58 MMP14 PCNA PTGS2
5 establishment of skin barrier GO:0061436 9.48 FLG TP63
6 response to vitamin D GO:0033280 9.46 PTGS2 TYR
7 cornification GO:0070268 9.43 FLG KRT17 KRT20
8 intermediate filament organization GO:0045109 9.37 KRT17 KRT20
9 melanin biosynthetic process GO:0042438 9.16 MC1R TYR
10 replicative senescence GO:0090399 8.96 CDKN2A TP53
11 cellular response to UV GO:0034644 8.8 PCNA PTGS2 TP53

Molecular functions related to Actinic Keratosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.53 CDKN2A FLG KRT17 KRT20 LUM MC1R
2 enzyme binding GO:0019899 9.26 MCM2 PCNA PTGS2 TP53
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Sources for Actinic Keratosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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