MCID: ACT164
MIFTS: 49

Actinic Prurigo

Categories: Genetic diseases, Rare diseases, Skin diseases

Aliases & Classifications for Actinic Prurigo

MalaCards integrated aliases for Actinic Prurigo:

Name: Actinic Prurigo 58 60 74
Hereditary Polymorphous Light Eruption of American Indians 60
Familial Polymorphous Light Eruption of American Indians 60
Polymorphic Light Eruption, Hereditary; Hple 58
Polymorphic Light Eruption, Hereditary 58
Hutchinson Summer Prurigo 60
Hydroa Aestivale 60
Hple 58

Characteristics:

Orphanet epidemiological data:

60
actinic prurigo
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Childhood;

OMIM:

58
Inheritance:
autosomal dominant


HPO:

33
actinic prurigo:
Inheritance autosomal dominant inheritance


Classifications:

Orphanet: 60  
Rare skin diseases


External Ids:

OMIM 58 174770
ICD10 via Orphanet 35 L56.4
UMLS via Orphanet 75 C0406217
Orphanet 60 ORPHA330061
MedGen 43 C0406217
UMLS 74 C0406217

Summaries for Actinic Prurigo

OMIM : 58 Hereditary polymorphic light eruption is a form of photosensitivity found in the American Indians of the central plains of Canada and the United States and in the Indians of Central and South America. The disorder has also been called familial actinic prurigo, solar dermatitis, and hydroa aestivale. In northern latitudes, skin lesions appear on exposed areas early in spring, become severe during the summer, and abate in the fall. Usually the disorder appears in childhood with eczematous crusted eruptions on the face and arms. Fissured, crusted exudative cheilitis develops on the lips, especially the lower lip. The dorsum of the hands, the laterodorsal aspects of the forearms, and the lower half of the arms often show excoriated papular and nodular lesions. Children frequently have complicating pyoderma. Adults usually exhibit an erythematous plaquelike eruption on the face and other exposed areas. The disease is more severe in children than in adults. Glomerulonephritis can follow streptococcal pyoderma (summary by Fusaro and Johnson, 1980). (174770)

MalaCards based summary : Actinic Prurigo, also known as hereditary polymorphous light eruption of american indians, is related to cutaneous lupus erythematosus and allergic contact dermatitis. An important gene associated with Actinic Prurigo is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. Affiliated tissues include skin, testes and b cells, and related phenotypes are cheilitis and cutaneous photosensitivity

Wikipedia : 77 Actinic prurigo is a rare sunlight-induced, pruritic, papular or nodular skin eruption. Some medical... more...

Related Diseases for Actinic Prurigo

Diseases related to Actinic Prurigo via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 146)
# Related Disease Score Top Affiliating Genes
1 cutaneous lupus erythematosus 30.2 ICAM1 SELE TNF
2 allergic contact dermatitis 29.7 ICAM1 IL1B SELE TNF
3 contact dermatitis 29.7 ICAM1 IL1B SELE TNF
4 porphyria 10.5
5 microscopic polyangiitis 10.4 HLA-DRB1 TNF
6 beryllium disease 10.4 HLA-DRB1 TNF
7 chronic beryllium disease 10.4 HLA-DRB1 TNF
8 whipple disease 10.4 CD58 HLA-DRB1
9 lethal midline granuloma 10.3 CD2 ICAM1
10 autoimmune enteropathy 10.3 ICAM1 ITGAL
11 microscopic colitis 10.3 HLA-DRB1 TNF
12 sympathetic ophthalmia 10.3 HLA-DRB1 TNF
13 penicilliosis 10.3 ITGAL TNF
14 critical limb ischemia 10.3 SELE TNF
15 scleritis 10.3 SELE TNF
16 nontuberculous mycobacterial lung disease 10.3 HLA-DRB1 TNF
17 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL13 TNF
18 pediatric multiple sclerosis 10.3 HLA-DRB1 ITGA4
19 protoporphyria, erythropoietic, 1 10.3
20 hypertrichosis 10.3
21 hydroa vacciniforme 10.3
22 heterophyiasis 10.3 ICAM1 SELE
23 mesial temporal lobe epilepsy with hippocampal sclerosis 10.3 HLA-DRB1 IL1B
24 exudative glomerulonephritis 10.3 IL1B TNF
25 trichuriasis 10.3 IL13 TNF
26 staphylococcal toxic shock syndrome 10.3 IL1B TNF
27 diffuse infiltrative lymphocytosis syndrome 10.3 ITGAL TNF
28 marburg hemorrhagic fever 10.3 ICAM3 TNF
29 hymenolepiasis 10.3 ICAM1 SELE
30 kashin-beck disease 10.3 IL1B TNF
31 trichosporonosis 10.3 ICAM3 TNF
32 vulvar vestibulitis syndrome 10.3 IL1B TNF
33 burns 10.2 IL1B TNF
34 plummer's disease 10.2 ICAM1 SELE
35 glossitis 10.2 IL1B TNF
36 laryngitis 10.2 IL1B TNF
37 haemophilus influenzae 10.2 IL1B TNF
38 cerebral artery occlusion 10.2 IL1B TNF
39 opisthorchiasis 10.2 IL1B TNF
40 lichen planus 10.2 ICAM1 ITGAL TNF
41 irritant dermatitis 10.2 IL1B TNF
42 acute vascular insufficiency of intestine 10.2 IL1B TNF
43 lepromatous leprosy 10.2 CD2 ICAM1 TNF
44 congenital cytomegalovirus 10.2 IL1B TNF
45 african tick-bite fever 10.2 IL13 SELE
46 osteosclerotic myeloma 10.2 IL1B TNF
47 cheilitis 10.2
48 focal segmental glomerulosclerosis 1 10.2 ICAM1 IL1B
49 diversion colitis 10.2 ICAM1 IL1B
50 pustulosis palmaris et plantaris 10.2 ITGAL SELE TNF

Graphical network of the top 20 diseases related to Actinic Prurigo:



Diseases related to Actinic Prurigo

Symptoms & Phenotypes for Actinic Prurigo

Human phenotypes related to Actinic Prurigo:

33
# Description HPO Frequency HPO Source Accession
1 cheilitis 33 HP:0100825
2 cutaneous photosensitivity 33 HP:0000992
3 glomerulonephritis 33 HP:0000099
4 pyoderma 33 HP:0000999

Symptoms via clinical synopsis from OMIM:

58
Skin:
photosensitivity
actinic prurigo
solar dermatitis
hydroa aestivale
eczematous crusted eruptions on face and arms
more
G U:
glomerulonephritis can follow streptococcal pyoderma

Misc:
found in indians of north, central and south america
frequent complicating pyoderma
more severe in children than in adults
oral beta carotene provides photoprotection

Clinical features from OMIM:

174770

GenomeRNAi Phenotypes related to Actinic Prurigo according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.5 ITGA4
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.5 IL1B ITGA4
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 9.5 IL1B
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.5 CD58
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.5 CD58 ITGA4
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-150 9.5 CD58
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.5 IL13
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.5 CD58 IL13 IL1B ITGA4
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.5 IL13
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-62 9.5 CD58

MGI Mouse Phenotypes related to Actinic Prurigo:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.61 CD69 ICAM1 IL13 IL1B ITGA4 ITGAL
2 immune system MP:0005387 9.28 CD69 ICAM1 IL13 IL1B ITGA4 ITGAL

Drugs & Therapeutics for Actinic Prurigo

Search Clinical Trials , NIH Clinical Center for Actinic Prurigo

Genetic Tests for Actinic Prurigo

Anatomical Context for Actinic Prurigo

MalaCards organs/tissues related to Actinic Prurigo:

42
Skin, Testes, B Cells, Lung, Colon, Bone, Heart

Publications for Actinic Prurigo

Articles related to Actinic Prurigo:

(show top 50) (show all 99)
# Title Authors Year
1
Expression of E-cadherin, syndecan 1, Ki-67, and maintenance minichromosome 3 in tissue lesions of actinic prurigo obtained by incisional biopsy. ( 29676362 )
2018
2
Serum cytokine profiling in patients with actinic prurigo. ( 30530429 )
2018
3
Actinic prurigo as a hypersensitivity reaction type 4. ( 28239837 )
2017
4
Actinic Prurigo in Scandinavian Adolescent Successfully Treated with Cyclosporine A. ( 29142659 )
2017
5
Risk factors associated with actinic prurigo: a case control study. ( 29364431 )
2017
6
Adult-onset actinic prurigo: report of 19 patients from Taiwan. ( 26538497 )
2016
7
Apoptosis and apoptotic pathway in actinic prurigo by immunohistochemistry. ( 26615506 )
2016
8
Actinic Prurigo in Singaporean Chinese: A Positive Association with HLA-DRB1*03:01. ( 26787110 )
2016
9
Characteristics of actinic prurigo in Scotland: 24 cases seen between 2001 and 2015. ( 26847497 )
2016
10
Actinic Prurigo Cheilitis: A Clinicopathologic Review of 75 Cases. ( 26981737 )
2016
11
Correlation of serum IgE levels and clinical manifestations in patients with actinic prurigo. ( 26982774 )
2016
12
Determination of apoptosis in actinic prurigo by TUNEL technique. ( 25377923 )
2015
13
Allergic contact dermatitis to Parthenium hysterophorus mimicking actinic prurigo. ( 25566915 )
2015
14
Oral and Maxillofacial Pathology. Case of the Month. Actinic prurigo. ( 26234110 )
2015
15
Inmunohistochemical detection of mastocytes in tissue from patients with actinic prurigo. ( 26644844 )
2015
16
Actinic Prurigo. ( 26861426 )
2015
17
Actinic prurigo: a case-control study of risk factors. ( 23968196 )
2014
18
Actinic prurigo. ( 24891055 )
2014
19
Actinic prurigo of the lip: Two case reports. ( 25133153 )
2014
20
Clinical characteristics of adult-onset actinic prurigo in Asians: a case series. ( 24177610 )
2013
21
Chronic actinic prurigo presenting in an adopted child. ( 20199425 )
2010
22
Case for diagnosis. Actinic prurigo. ( 21152806 )
2010
23
Epidermal Langerhans cells in Actinic Prurigo: a comparison between lesional and non-lesional skin. ( 19335731 )
2009
24
Hypodontia in a patient with actinic prurigo: a case report. ( 19619430 )
2009
25
Epidermal Langerhans cells in actinic prurigo: a comparison between lesional and non-lesional skin. ( 19744180 )
2009
26
Actinic prurigo. ( 18811871 )
2008
27
Class I and class II major histocompatibility complex genes in Mexican patients with actinic prurigo. ( 17355228 )
2007
28
Actinic prurigo deterioration due to degradation of DermaGard window film. ( 17553049 )
2007
29
Adult-onset actinic prurigo in Thailand. ( 17986059 )
2007
30
Actinic prurigo in an Albanian girl. ( 16445427 )
2006
31
Immune responses to isolated human skin antigens in actinic prurigo. ( 16501416 )
2006
32
Association of HLA subtype DRB10407 in Colombian patients with actinic prurigo. ( 16606409 )
2006
33
Successful thalidomide therapy for actinic prurigo in a European woman. ( 17081272 )
2006
34
Primary cutaneous B-cell lymphoma associated with actinic prurigo. ( 16029348 )
2005
35
Actinic prurigo. ( 16101881 )
2005
36
Pentoxifylline in the treatment of actinic prurigo. A preliminary report of 10 patients. ( 15118367 )
2004
37
Evidence that thalidomide modifies the immune response of patients suffering from actinic prurigo. ( 15569010 )
2004
38
Diagnosis and treatment of actinic prurigo. ( 12919125 )
2003
39
Actinic prurigo: a retrospective analysis of 21 cases referred to an Australian photobiology clinic. ( 11982570 )
2002
40
Lymphocyte subtypes and adhesion molecules in actinic prurigo: observations with cyclosporin A. ( 12010338 )
2002
41
Actinic prurigo cheilitis: clinicopathologic analysis and therapeutic results in 116 cases. ( 12193899 )
2002
42
Caucasian actinic prurigo: 8 cases observed in France. ( 11167711 )
2001
43
Actinic prurigo: clinical features and HLA associations in a Canadian Inuit population. ( 11369906 )
2001
44
Effectors of inflammation in actinic prurigo. ( 11369907 )
2001
45
A case of severe actinic prurigo successfully treated with thalidomide. ( 11488714 )
2001
46
A candidate gene analysis of three related photosensitivity disorders: cutaneous lupus erythematosus, polymorphic light eruption and actinic prurigo. ( 11531784 )
2001
47
Tumour necrosis factor alpha promoter polymorphism at position -308 is not associated with actinic prurigo. ( 11722460 )
2001
48
Long-term thalidomide for actinic prurigo. ( 11903163 )
2001
49
A case of actinic prurigo in Thailand. ( 10692819 )
2000
50
A case of actinic prurigo showing hypersensitivity of skin fibroblasts to ultraviolet A (UVA). ( 10721864 )
2000

Variations for Actinic Prurigo

Expression for Actinic Prurigo

Search GEO for disease gene expression data for Actinic Prurigo.

Pathways for Actinic Prurigo

Pathways related to Actinic Prurigo according to GeneCards Suite gene sharing:

(show all 50)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 CD58 HLA-DRB1 ICAM1 ICAM3 IL13 IL1B
2
Show member pathways
13.45 CD2 ICAM1 IL13 IL1B ITGA4 ITGAL
3
Show member pathways
13.36 HLA-DRB1 ICAM1 ICAM3 ITGA4 ITGAL VCAM1
4
Show member pathways
13.32 CD2 IL13 IL1B ITGA4 ITGAL TNF
5
Show member pathways
13.27 HLA-DRB1 ICAM1 IL13 IL1B TNF VCAM1
6
Show member pathways
12.83 HLA-DRB1 ICAM1 IL13 IL1B ITGA4 ITGAL
7
Show member pathways
12.7 ICAM1 ICAM3 ITGA4 ITGAL VCAM1
8
Show member pathways
12.58 ICAM1 ITGA4 ITGAL VCAM1
9
Show member pathways
12.52 HLA-DRB1 IL13 IL1B TNF
10 12.49 CD2 IL1B TNF VCAM1
11 12.33 HLA-DRB1 ICAM1 ITGAL TNF VCAM1
12
Show member pathways
12.23 CD2 CD58 ITGA4 ITGAL SELE
13
Show member pathways
12.22 HLA-DRB1 IL1B ITGA4 TNF
14
Show member pathways
12.16 ICAM1 IL1B ITGA4 ITGAL VCAM1
15
Show member pathways
12.14 ICAM1 ICAM3 ITGA4 ITGAL VCAM1
16 12.09 IL13 IL1B TNF
17 12.08 ICAM1 IL1B SELE TNF VCAM1
18 12.05 ICAM1 ICAM3 ITGA4 ITGAL VCAM1
19
Show member pathways
12 CD2 ICAM1 IL13 IL1B
20
Show member pathways
11.98 IL13 IL1B TNF
21 11.98 CD2 CD69 ITGAL TNF
22 11.97 ICAM1 IL13 IL1B TNF VCAM1
23 11.96 ICAM1 ITGA4 VCAM1
24
Show member pathways
11.96 IL13 IL1B ITGA4
25 11.94 ICAM1 IL1B TNF
26 11.93 ICAM1 IL1B SELE TNF VCAM1
27 11.9 ICAM1 IL1B TNF VCAM1
28 11.85 ICAM1 IL1B SELE TNF VCAM1
29 11.82 CD2 HLA-DRB1 IL1B ITGA4 TNF
30 11.79 IL13 IL1B ITGA4 TNF
31 11.76 ICAM1 IL13 SELE
32 11.76 HLA-DRB1 ICAM1 IL1B ITGAL TNF
33 11.69 IL13 IL1B TNF
34 11.66 HLA-DRB1 ICAM1 ITGAL
35 11.63 IL13 IL1B TNF
36
Show member pathways
11.57 ICAM1 IL1B SELE TNF VCAM1
37 11.56 ICAM1 IL13 IL1B TNF
38 11.47 ICAM1 SELE VCAM1
39
Show member pathways
11.45 ITGA4 ITGAL VCAM1
40 11.44 CD2 CD58 HLA-DRB1 ICAM1 ICAM3 ITGA4
41 11.3 IL13 IL1B TNF
42 11.3 ICAM1 ICAM3 ITGA4 ITGAL VCAM1
43 11.24 HLA-DRB1 IL13 IL1B TNF
44 11.17 CD2 IL13 IL1B TNF
45 11.13 IL1B TNF VCAM1
46 11.12 ICAM1 IL1B SELE TNF VCAM1
47 11.12 ICAM1 IL1B ITGAL SELE TNF VCAM1
48 11.11 ICAM1 IL1B
49 10.99 CD2 IL13 IL1B ITGA4 ITGAL TNF
50 10.83 ICAM1 IL1B TNF VCAM1

GO Terms for Actinic Prurigo

Cellular components related to Actinic Prurigo according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.86 CD58 HLA-DRB1 ICAM1 ICAM3 IL1B ITGA4
2 integral component of plasma membrane GO:0005887 9.76 CD2 CD58 CD69 ICAM1 ICAM3 SELE
3 external side of plasma membrane GO:0009897 9.5 CD2 CD69 HLA-DRB1 ICAM1 IL13 TNF
4 cell surface GO:0009986 9.28 CD2 CD58 CD69 HLA-DRB1 ICAM1 ITGA4
5 plasma membrane GO:0005886 10.07 CD2 CD58 HLA-DRB1 ICAM1 ICAM3 ITGA4
6 integral component of membrane GO:0016021 10.06 CD2 CD58 CD69 HLA-DRB1 ICAM1 ICAM3

Biological processes related to Actinic Prurigo according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.95 CD2 ICAM1 ICAM3 ITGA4 ITGAL SELE
2 inflammatory response GO:0006954 9.92 IL13 IL1B ITGAL SELE TNF
3 cytokine-mediated signaling pathway GO:0019221 9.88 ICAM1 IL13 IL1B TNF VCAM1
4 cellular response to lipopolysaccharide GO:0071222 9.85 ICAM1 IL1B TNF
5 regulation of immune response GO:0050776 9.85 ICAM1 ICAM3 ITGA4 ITGAL VCAM1
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.84 ICAM1 IL1B TNF
7 cellular response to tumor necrosis factor GO:0071356 9.83 CD58 ICAM1 VCAM1
8 response to lipopolysaccharide GO:0032496 9.83 ICAM1 IL13 IL1B SELE VCAM1
9 cell-matrix adhesion GO:0007160 9.8 ITGA4 ITGAL VCAM1
10 extracellular matrix organization GO:0030198 9.8 ICAM1 ICAM3 ITGA4 ITGAL TNF VCAM1
11 interferon-gamma-mediated signaling pathway GO:0060333 9.79 HLA-DRB1 ICAM1 VCAM1
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.73 ICAM1 IL1B TNF
13 heterotypic cell-cell adhesion GO:0034113 9.69 CD2 CD58 ITGA4
14 negative regulation of neurogenesis GO:0050768 9.67 IL1B TNF
15 response to ethanol GO:0045471 9.67 ICAM1 IL13 VCAM1
16 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.67 ICAM1 ITGAL SELE VCAM1
17 microglial cell activation GO:0001774 9.66 IL13 TNF
18 negative regulation of lipid catabolic process GO:0050995 9.65 IL1B TNF
19 positive regulation of glial cell proliferation GO:0060252 9.65 IL1B TNF
20 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.65 IL1B TNF
21 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.64 IL1B TNF
22 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.64 IL1B TNF
23 positive regulation of interleukin-8 secretion GO:2000484 9.63 CD2 CD58
24 cell-cell adhesion GO:0098609 9.63 CD2 CD58 ICAM1 ICAM3 ITGAL VCAM1
25 positive regulation of chemokine biosynthetic process GO:0045080 9.62 IL1B TNF
26 regulation of establishment of endothelial barrier GO:1903140 9.61 IL1B TNF
27 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.61 ICAM1 TNF
28 positive regulation of neuroinflammatory response GO:0150078 9.6 IL1B TNF
29 membrane to membrane docking GO:0022614 9.59 ICAM1 VCAM1
30 positive regulation of fever generation GO:0031622 9.58 IL1B TNF
31 sequestering of triglyceride GO:0030730 9.57 IL1B TNF
32 leukocyte tethering or rolling GO:0050901 9.56 ITGA4 SELE TNF VCAM1
33 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.55 IL1B TNF
34 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:0002291 9.54 ICAM1 ITGAL
35 leukocyte cell-cell adhesion GO:0007159 9.35 ICAM1 ITGA4 ITGAL SELE VCAM1
36 chronic inflammatory response to antigenic stimulus GO:0002439 9.27 TNF
37 leukocyte migration GO:0050900 9.23 CD2 CD58 ICAM1 IL1B ITGA4 ITGAL

Molecular functions related to Actinic Prurigo according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion molecule binding GO:0050839 9.13 ITGA4 ITGAL VCAM1
2 integrin binding GO:0005178 8.92 ICAM1 ICAM3 IL1B VCAM1

Sources for Actinic Prurigo

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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