MCID: ACT164
MIFTS: 48

Actinic Prurigo

Categories: Skin diseases, Rare diseases, Genetic diseases

Aliases & Classifications for Actinic Prurigo

MalaCards integrated aliases for Actinic Prurigo:

Name: Actinic Prurigo 57 59 73
Hereditary Polymorphous Light Eruption of American Indians 59
Familial Polymorphous Light Eruption of American Indians 59
Polymorphic Light Eruption, Hereditary; Hple 57
Polymorphic Light Eruption, Hereditary 57
Hutchinson Summer Prurigo 59
Hydroa Aestivale 59
Hple 57

Characteristics:

Orphanet epidemiological data:

59
actinic prurigo
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Childhood;

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
actinic prurigo:
Inheritance autosomal dominant inheritance


Classifications:

Orphanet: 59  
Rare skin diseases


External Ids:

OMIM 57 174770
Orphanet 59 ORPHA330061
ICD10 via Orphanet 34 L56.4
UMLS via Orphanet 74 C0406217
MedGen 42 C0406217
UMLS 73 C0406217

Summaries for Actinic Prurigo

OMIM : 57 Hereditary polymorphic light eruption is a form of photosensitivity found in the American Indians of the central plains of Canada and the United States and in the Indians of Central and South America. The disorder has also been called familial actinic prurigo, solar dermatitis, and hydroa aestivale. In northern latitudes, skin lesions appear on exposed areas early in spring, become severe during the summer, and abate in the fall. Usually the disorder appears in childhood with eczematous crusted eruptions on the face and arms. Fissured, crusted exudative cheilitis develops on the lips, especially the lower lip. The dorsum of the hands, the laterodorsal aspects of the forearms, and the lower half of the arms often show excoriated papular and nodular lesions. Children frequently have complicating pyoderma. Adults usually exhibit an erythematous plaquelike eruption on the face and other exposed areas. The disease is more severe in children than in adults. Glomerulonephritis can follow streptococcal pyoderma (summary by Fusaro and Johnson, 1980). (174770)

MalaCards based summary : Actinic Prurigo, also known as hereditary polymorphous light eruption of american indians, is related to cutaneous lupus erythematosus and allergic contact dermatitis. An important gene associated with Actinic Prurigo is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. Affiliated tissues include skin, testes and b cells, and related phenotypes are cheilitis and cutaneous photosensitivity

Wikipedia : 76 Actinic prurigo is a rare sunlight-induced, pruritic, papular or nodular skin eruption. Some medical... more...

Related Diseases for Actinic Prurigo

Diseases related to Actinic Prurigo via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 137)
# Related Disease Score Top Affiliating Genes
1 cutaneous lupus erythematosus 30.1 ICAM1 SELE TNF
2 allergic contact dermatitis 29.6 ICAM1 IL1B SELE TNF
3 contact dermatitis 29.6 ICAM1 IL1B SELE TNF
4 microscopic polyangiitis 10.9 HLA-DRB1 TNF
5 beryllium disease 10.8 HLA-DRB1 TNF
6 autoimmune pancreatitis 10.8 HLA-DRB1 TNF
7 chronic beryllium disease 10.8 HLA-DRB1 TNF
8 systemic onset juvenile idiopathic arthritis 10.8 IL1B TNF
9 staphylococcal toxic shock syndrome 10.8 IL1B TNF
10 autoimmune myocarditis 10.8 IL1B TNF
11 anca-associated vasculitis 10.8 HLA-DRB1 TNF
12 kashin-beck disease 10.8 IL1B TNF
13 lichen sclerosus 10.8 HLA-DRB1 TNF
14 vulvar vestibulitis syndrome 10.7 IL1B TNF
15 burns 10.7 IL1B TNF
16 critical limb ischemia 10.7 SELE TNF
17 laryngitis 10.7 IL1B TNF
18 cerebral artery occlusion 10.7 IL1B TNF
19 whipple disease 10.7 CD58 HLA-DRB1
20 haemophilus influenzae 10.7 IL1B TNF
21 scleritis 10.7 SELE TNF
22 irritant dermatitis 10.6 IL1B TNF
23 acute vascular insufficiency of intestine 10.6 IL1B TNF
24 penicilliosis 10.6 ITGAL TNF
25 sympathetic ophthalmia 10.6 HLA-DRB1 TNF
26 poems syndrome 10.6 IL1B TNF
27 funisitis 10.6 IL1B SELE
28 angioimmunoblastic lymphadenopathy with dysproteinemia 10.6 IL13 TNF
29 crohn's colitis 10.6 IL1B TNF
30 central nervous system vasculitis 10.6 HLA-DRB1 IL1B TNF
31 autoimmune enteropathy 10.5 ICAM1 ITGAL
32 palindromic rheumatism 10.5 HLA-DRB1 IL1B TNF
33 idiopathic neutropenia 10.5 HLA-DRB1 IL1B TNF
34 nontuberculous mycobacterial lung disease 10.5 HLA-DRB1 TNF
35 diversion colitis 10.5 ICAM1 IL1B
36 lethal midline granuloma 10.5 CD2 ICAM1
37 bone inflammation disease 10.5 HLA-DRB1 IL1B TNF
38 helicobacter pylori infection 10.5 HLA-DRB1 IL1B TNF
39 juvenile rheumatoid arthritis 10.5 HLA-DRB1 IL1B TNF
40 graft-versus-host disease 10.5 HLA-DRB1 IL1B TNF
41 heterophyiasis 10.5 ICAM1 SELE
42 microscopic colitis 10.5 HLA-DRB1 TNF
43 pustulosis palmaris et plantaris 10.5 ITGAL SELE TNF
44 trichuriasis 10.4 IL13 TNF
45 retinitis pigmentosa 60 10.4 IL1B SELE TNF
46 rheumatic heart disease 10.4 HLA-DRB1 TNF VCAM1
47 endometritis 10.4 IL1B SELE TNF
48 african tick-bite fever 10.4 IL13 SELE
49 plummer's disease 10.4 ICAM1 SELE
50 viral encephalitis 10.4 IL1B TNF VCAM1

Graphical network of the top 20 diseases related to Actinic Prurigo:



Diseases related to Actinic Prurigo

Symptoms & Phenotypes for Actinic Prurigo

Symptoms via clinical synopsis from OMIM:

57
Skin:
photosensitivity
actinic prurigo
solar dermatitis
hydroa aestivale
eczematous crusted eruptions on face and arms
more
GU:
glomerulonephritis can follow streptococcal pyoderma

Misc:
found in indians of north, central and south america
frequent complicating pyoderma
more severe in children than in adults
oral beta carotene provides photoprotection


Clinical features from OMIM:

174770

Human phenotypes related to Actinic Prurigo:

32
# Description HPO Frequency HPO Source Accession
1 cheilitis 32 HP:0100825
2 cutaneous photosensitivity 32 HP:0000992
3 pyoderma 32 HP:0000999
4 glomerulonephritis 32 HP:0000099

GenomeRNAi Phenotypes related to Actinic Prurigo according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.5 ITGA4
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.5 IL1B ITGA4
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 9.5 IL1B
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.5 CD58
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.5 CD58 ITGA4
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-150 9.5 CD58
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.5 IL13
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.5 CD58 IL13 IL1B ITGA4
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.5 IL13
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-62 9.5 CD58

MGI Mouse Phenotypes related to Actinic Prurigo:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.61 CD69 ICAM1 IL13 IL1B ITGA4 ITGAL
2 immune system MP:0005387 9.28 CD69 ICAM1 IL13 IL1B ITGA4 ITGAL

Drugs & Therapeutics for Actinic Prurigo

Search Clinical Trials , NIH Clinical Center for Actinic Prurigo

Genetic Tests for Actinic Prurigo

Anatomical Context for Actinic Prurigo

MalaCards organs/tissues related to Actinic Prurigo:

41
Skin, Testes, B Cells

Publications for Actinic Prurigo

Articles related to Actinic Prurigo:

(show top 50) (show all 99)
# Title Authors Year
1
Actinic Prurigo ( 29763132 )
2018
2
Expression of E-cadherin, syndecan 1, Ki-67, and maintenance minichromosome 3 in tissue lesions of actinic prurigo obtained by incisional biopsy. ( 29676362 )
2018
3
Risk factors associated with actinic prurigo: a case control study. ( 29364431 )
2017
4
Actinic Prurigo in Scandinavian Adolescent Successfully Treated with Cyclosporine A. ( 29142659 )
2017
5
Actinic prurigo as a hypersensitivity reaction type 4. ( 28239837 )
2017
6
Apoptosis and apoptotic pathway in actinic prurigo by immunohistochemistry. ( 26615506 )
2016
7
Actinic Prurigo Cheilitis: A Clinicopathologic Review of 75 Cases. ( 26981737 )
2016
8
Correlation of serum IgE levels and clinical manifestations in patients with actinic prurigo. ( 26982774 )
2016
9
Actinic Prurigo in Singaporean Chinese: A Positive Association with HLA-DRB1*03:01. ( 26787110 )
2016
10
Characteristics of actinic prurigo in Scotland: 24 cases seen between 2001 -2015. ( 26847497 )
2016
11
Allergic contact dermatitis to Parthenium hysterophorus mimicking actinic prurigo. ( 25566915 )
2015
12
Adult-onset actinic prurigo: report of 19 patients from Taiwan. ( 26538497 )
2015
13
Actinic Prurigo. ( 26861426 )
2015
14
Oral and Maxillofacial Pathology. Case of the Month. Actinic prurigo. ( 26234110 )
2015
15
Inmunohistochemical detection of mastocytes in tissue from patients with actinic prurigo. ( 26644844 )
2015
16
Actinic prurigo. ( 24891055 )
2014
17
Determination of apoptosis in actinic prurigo by TUNEL technique. ( 25377923 )
2014
18
Actinic prurigo of the lip: Two case reports. ( 25133153 )
2014
19
Clinical characteristics of adult-onset actinic prurigo in Asians: a case series. ( 24177610 )
2013
20
Actinic prurigo: a case-control study of risk factors. ( 23968196 )
2013
21
Chronic actinic prurigo presenting in an adopted child. ( 20199425 )
2010
22
Case for diagnosis. Actinic prurigo. ( 21152806 )
2010
23
Hypodontia in a patient with actinic prurigo: a case report. ( 19619430 )
2009
24
Epidermal Langerhans cells in Actinic Prurigo: a comparison between lesional and non-lesional skin. ( 19335731 )
2009
25
Epidermal Langerhans cells in actinic prurigo: a comparison between lesional and non-lesional skin. ( 19744180 )
2009
26
Actinic prurigo. ( 18811871 )
2008
27
Adult-onset actinic prurigo in Thailand. ( 17986059 )
2007
28
Actinic prurigo deterioration due to degradation of DermaGard window film. ( 17553049 )
2007
29
Class I and class II major histocompatibility complex genes in Mexican patients with actinic prurigo. ( 17355228 )
2007
30
Immune responses to isolated human skin antigens in actinic prurigo. ( 16501416 )
2006
31
Association of HLA subtype DRB10407 in Colombian patients with actinic prurigo. ( 16606409 )
2006
32
Successful thalidomide therapy for actinic prurigo in a European woman. ( 17081272 )
2006
33
Actinic prurigo in an Albanian girl. ( 16445427 )
2006
34
Actinic prurigo. ( 16101881 )
2005
35
Primary cutaneous B-cell lymphoma associated with actinic prurigo. ( 16029348 )
2005
36
Evidence that thalidomide modifies the immune response of patients suffering from actinic prurigo. ( 15569010 )
2004
37
Pentoxifylline in the treatment of actinic prurigo. A preliminary report of 10 patients. ( 15118367 )
2004
38
Diagnosis and treatment of actinic prurigo. ( 12919125 )
2003
39
Actinic prurigo cheilitis: clinicopathologic analysis and therapeutic results in 116 cases. ( 12193899 )
2002
40
Actinic prurigo: a retrospective analysis of 21 cases referred to an Australian photobiology clinic. ( 11982570 )
2002
41
Lymphocyte subtypes and adhesion molecules in actinic prurigo: observations with cyclosporin A. ( 12010338 )
2002
42
Actinic prurigo: clinical features and HLA associations in a Canadian Inuit population. ( 11369906 )
2001
43
Caucasian actinic prurigo: 8 cases observed in France. ( 11167711 )
2001
44
A case of severe actinic prurigo successfully treated with thalidomide. ( 11488714 )
2001
45
Tumour necrosis factor alpha promoter polymorphism at position -308 is not associated with actinic prurigo. ( 11722460 )
2001
46
Effectors of inflammation in actinic prurigo. ( 11369907 )
2001
47
A candidate gene analysis of three related photosensitivity disorders: cutaneous lupus erythematosus, polymorphic light eruption and actinic prurigo. ( 11531784 )
2001
48
Long-term thalidomide for actinic prurigo. ( 11903163 )
2001
49
Use of topical cyclosporin for conjunctival manifestations of actinic prurigo. ( 11124306 )
2000
50
The conjunctivitis of solar (actinic) prurigo. ( 11123772 )
2000

Variations for Actinic Prurigo

Expression for Actinic Prurigo

Search GEO for disease gene expression data for Actinic Prurigo.

Pathways for Actinic Prurigo

Pathways related to Actinic Prurigo according to GeneCards Suite gene sharing:

(show all 47)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 CD58 HLA-DRB1 ICAM1 ICAM3 IL13 IL1B
2
Show member pathways
13.41 CD2 IL13 IL1B ITGA4 ITGAL TNF
3
Show member pathways
13.35 HLA-DRB1 ICAM1 ICAM3 ITGA4 ITGAL VCAM1
4
Show member pathways
13.31 CD2 IL13 IL1B ITGA4 ITGAL TNF
5
Show member pathways
13.26 HLA-DRB1 ICAM1 IL13 IL1B TNF VCAM1
6
Show member pathways
12.85 HLA-DRB1 ICAM1 IL13 IL1B ITGA4 ITGAL
7
Show member pathways
12.74 HLA-DRB1 ICAM1 IL13 IL1B TNF
8
Show member pathways
12.69 ICAM1 ICAM3 ITGA4 ITGAL VCAM1
9
Show member pathways
12.57 ICAM1 ITGA4 ITGAL VCAM1
10 12.48 CD2 IL1B TNF VCAM1
11 12.4 HLA-DRB1 ICAM1 ITGAL TNF VCAM1
12
Show member pathways
12.38 HLA-DRB1 IL13 IL1B TNF
13 12.25 CD58 HLA-DRB1 ICAM1 ITGAL
14
Show member pathways
12.23 CD2 CD58 ITGA4 ITGAL SELE
15
Show member pathways
12.21 HLA-DRB1 IL1B ITGA4 TNF
16
Show member pathways
12.12 ICAM1 ICAM3 ITGA4 ITGAL VCAM1
17 12.09 IL13 IL1B TNF
18 12.08 ICAM1 IL1B SELE TNF VCAM1
19 12.05 ICAM1 ICAM3 ITGA4 ITGAL VCAM1
20
Show member pathways
12 CD2 ICAM1 IL13 IL1B
21 11.98 CD2 CD69 ITGAL TNF
22 11.97 ICAM1 IL13 IL1B TNF VCAM1
23
Show member pathways
11.95 IL13 IL1B ITGA4
24 11.94 ICAM1 ITGA4 VCAM1
25 11.93 ICAM1 IL1B TNF
26 11.93 ICAM1 IL1B SELE TNF VCAM1
27 11.88 ICAM1 IL1B TNF VCAM1
28 11.85 ICAM1 IL1B SELE TNF VCAM1
29 11.82 CD2 HLA-DRB1 IL1B ITGA4 TNF
30 11.79 IL13 IL1B ITGA4 TNF
31 11.76 ICAM1 IL13 SELE
32 11.76 HLA-DRB1 ICAM1 IL1B ITGAL TNF
33 11.63 IL13 IL1B TNF
34 11.57 HLA-DRB1 ICAM1 ITGAL
35
Show member pathways
11.57 ICAM1 IL1B SELE TNF VCAM1
36 11.55 ICAM1 IL13 IL1B TNF
37 11.46 ICAM1 SELE VCAM1
38
Show member pathways
11.44 ITGA4 ITGAL VCAM1
39 11.43 CD2 CD58 HLA-DRB1 ICAM1 ICAM3 ITGA4
40 11.3 IL13 IL1B TNF
41 11.3 ICAM1 ICAM3 ITGA4 ITGAL VCAM1
42 11.26 HLA-DRB1 IL13 IL1B TNF
43 11.12 IL1B TNF VCAM1
44 11.12 ICAM1 IL1B ITGAL SELE TNF VCAM1
45 11.1 ICAM1 IL1B
46 11.1 ICAM1 IL1B SELE TNF VCAM1
47 10.83 ICAM1 IL1B TNF VCAM1

GO Terms for Actinic Prurigo

Cellular components related to Actinic Prurigo according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.97 CD58 HLA-DRB1 ICAM1 ICAM3 IL1B ITGA4
2 integral component of plasma membrane GO:0005887 9.7 CD2 CD58 CD69 ICAM1 ICAM3 SELE
3 cell surface GO:0009986 9.56 CD2 CD58 HLA-DRB1 ICAM1 ITGA4 ITGAL
4 external side of plasma membrane GO:0009897 9.17 CD2 CD69 HLA-DRB1 ICAM1 IL13 TNF
5 plasma membrane GO:0005886 10.02 CD2 CD58 HLA-DRB1 ICAM1 ICAM3 ITGA4
6 integral component of membrane GO:0016021 10 CD2 CD58 CD69 HLA-DRB1 ICAM1 ICAM3

Biological processes related to Actinic Prurigo according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.93 IL13 IL1B ITGAL SELE TNF
2 cell adhesion GO:0007155 9.92 CD2 CD58 ICAM1 ICAM3 ITGA4 ITGAL
3 cytokine-mediated signaling pathway GO:0019221 9.89 ICAM1 IL13 IL1B TNF VCAM1
4 regulation of immune response GO:0050776 9.85 ICAM1 ICAM3 ITGA4 ITGAL VCAM1
5 extracellular matrix organization GO:0030198 9.85 ICAM1 ICAM3 ITGA4 ITGAL TNF VCAM1
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.83 ICAM1 IL1B TNF
7 response to lipopolysaccharide GO:0032496 9.83 ICAM1 IL13 IL1B SELE VCAM1
8 cellular response to tumor necrosis factor GO:0071356 9.82 CD58 ICAM1 VCAM1
9 response to ethanol GO:0045471 9.8 ICAM1 IL13 VCAM1
10 cell-matrix adhesion GO:0007160 9.79 ITGA4 ITGAL VCAM1
11 interferon-gamma-mediated signaling pathway GO:0060333 9.77 HLA-DRB1 ICAM1 VCAM1
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.72 ICAM1 IL1B TNF
13 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.71 ICAM1 ITGAL SELE VCAM1
14 receptor clustering GO:0043113 9.65 ITGA4 ITGAL
15 heterotypic cell-cell adhesion GO:0034113 9.65 CD2 CD58 ITGA4
16 negative regulation of lipid catabolic process GO:0050995 9.64 IL1B TNF
17 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.64 IL1B TNF
18 positive regulation of interleukin-8 secretion GO:2000484 9.63 CD2 CD58
19 cell-cell adhesion GO:0098609 9.63 CD2 CD58 ICAM1 ICAM3 ITGAL VCAM1
20 inflammatory response to antigenic stimulus GO:0002437 9.62 HLA-DRB1 IL1B
21 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.62 IL1B TNF
22 positive regulation of chemokine biosynthetic process GO:0045080 9.61 IL1B TNF
23 regulation of establishment of endothelial barrier GO:1903140 9.59 IL1B TNF
24 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.58 ICAM1 TNF
25 positive regulation of fever generation GO:0031622 9.58 IL1B TNF
26 membrane to membrane docking GO:0022614 9.57 ICAM1 VCAM1
27 sequestering of triglyceride GO:0030730 9.56 IL1B TNF
28 leukocyte tethering or rolling GO:0050901 9.56 ITGA4 SELE TNF VCAM1
29 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.52 IL1B TNF
30 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:0002291 9.51 ICAM1 ITGAL
31 leukocyte cell-cell adhesion GO:0007159 9.35 ICAM1 ITGA4 ITGAL SELE VCAM1
32 leukocyte migration GO:0050900 9.23 CD2 CD58 ICAM1 IL1B ITGA4 ITGAL

Molecular functions related to Actinic Prurigo according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.97 CD2 CD58 CD69 HLA-DRB1 ICAM1 ICAM3
2 cell adhesion molecule binding GO:0050839 9.13 ITGA4 ITGAL VCAM1
3 integrin binding GO:0005178 8.92 ICAM1 ICAM3 IL1B VCAM1

Sources for Actinic Prurigo

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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