MCID: ACT016
MIFTS: 30

Actinobacillosis

Categories: Infectious diseases, Respiratory diseases

Aliases & Classifications for Actinobacillosis

MalaCards integrated aliases for Actinobacillosis:

Name: Actinobacillosis 12 44 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:4974
MeSH 44 D000187
SNOMED-CT 67 16140007
UMLS 70 C0001247

Summaries for Actinobacillosis

Disease Ontology : 12 A commensal bacterial infectious disease that results in infection, has material basis in Actinobacillus ureae, which is a commensal of the human respiratory tract. The pathogen causes meningitis, endocarditis, bacteremia, atrophic rhinitis, bronchitis, pneumonia, conjunctivitis, peritonitis, and otitis media.

MalaCards based summary : Actinobacillosis is related to idiopathic eosinophilic pneumonia and xanthogranulomatous pyelonephritis, and has symptoms including lameness, animal An important gene associated with Actinobacillosis is CWC15 (CWC15 Spliceosome Associated Protein Homolog), and among its related pathways/superpathways are Hematopoietic cell lineage and IgA-Producing B Cells in the Intestine. Affiliated tissues include tongue, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 73 Actinobacillosis is a zoonotic disease caused by... more...

Related Diseases for Actinobacillosis

Diseases related to Actinobacillosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 idiopathic eosinophilic pneumonia 10.3 ITGB2 ITGAL
2 xanthogranulomatous pyelonephritis 10.2 EGF CD68
3 microphthalmia, syndromic 10 10.2 CWC15 CTTNBP2
4 nodular tenosynovitis 10.2 CYP19A1 CD68
5 granulomatous gastritis 10.2 CR2 CD68
6 periodontitis, aggressive, 1 10.2 ITGB2 IL1A
7 t-cell/histiocyte rich large b cell lymphoma 10.2 CR2 CD68
8 langerhans cell sarcoma 10.2 CR2 CD68
9 histiocytic and dendritic cell cancer 10.1 CR2 CD68
10 lymphohistiocytoid mesothelioma 10.1 CD68 CD5
11 malignant giant cell tumor of soft parts 10.1 CR2 CD68
12 ureteral lymphoma 10.1 CR2 CD5
13 lymphadenitis 10.0
14 chronic graft versus host disease 10.0 IL1A CD79A
15 pustulosis palmaris et plantaris 10.0 ITGB2 ITGAL CD79A
16 membranoproliferative glomerulonephritis 10.0 ITGB2 ITGAL CD79A
17 bladder lymphoma 10.0 CD79A CD5
18 dendritic cell tumor 10.0 CR2 CD68
19 epiglottis neoplasm 10.0 CD79A CD5
20 lung lymphoma 10.0 CD79A CD5
21 bone lymphoma 10.0 CD79A CD5
22 colon lymphoma 10.0 CD79A CD5
23 breast lymphoma 9.9 CD79A CD5
24 sclerosing hepatic carcinoma 9.9 CD79A CD5
25 esophageal tuberculosis 9.9 IL11 CR2 CD68
26 gastrointestinal lymphoma 9.9 CD79A CD5
27 prion disease 9.9 IL1A CR2 APP
28 alpha chain disease 9.9 CD79A CD5
29 breast osteosarcoma 9.9 CD79A CD5
30 actinomycosis 9.9
31 pneumonia 9.9
32 rhinitis 9.9
33 cellulitis 9.9
34 pericarditis 9.9
35 echinococcosis 9.9
36 glossitis 9.9
37 bronchopneumonia 9.9
38 pleurisy 9.9
39 mild cognitive impairment 9.9 BACE1 APP
40 vascular dementia 9.9 OCLN BACE1 APP
41 calciphylaxis 9.9 MGP CD79A
42 composite lymphoma 9.9 CD79A CD5
43 mediastinal cancer 9.8 CD79A CD5
44 gallbladder lymphoma 9.7 CR2 CD79A CD5
45 cryoglobulinemia 9.7 CR2 CD79A CD5
46 marginal zone b-cell lymphoma 9.7 CR2 CD79A CD5
47 mature t-cell and nk-cell lymphoma 9.7 CR2 CD79A CD5
48 mature b-cell neoplasm 9.7 CR2 CD79A CD5
49 lymphoma, mucosa-associated lymphoid type 9.7 CR2 CD79A CD5
50 plasmacytoma 9.7 IL11 CD79A CD5

Graphical network of the top 20 diseases related to Actinobacillosis:



Diseases related to Actinobacillosis

Symptoms & Phenotypes for Actinobacillosis

UMLS symptoms related to Actinobacillosis:


lameness, animal

GenomeRNAi Phenotypes related to Actinobacillosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00240-S-1 9.66 CWC15
2 Decreased viability GR00249-S 9.66 BACE1 CD79A CTTNBP2 IL1A SORD
3 Decreased viability GR00381-A-1 9.66 CD79A CTTNBP2 MGP PYY
4 Decreased viability GR00381-A-2 9.66 MGP
5 Decreased viability GR00381-A-3 9.66 CD79A MGP
6 Decreased viability GR00386-A-1 9.66 CD5 CD79A CWC15 OCLN SORD
7 Decreased viability GR00402-S-2 9.66 BACE1 CWC15 IL11 PYY

MGI Mouse Phenotypes related to Actinobacillosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10 APEX1 APP BACE1 CD79A CR2 CTTNBP2
2 immune system MP:0005387 9.77 APEX1 APP CD5 CD68 CD79A CR2
3 normal MP:0002873 9.32 APEX1 APP BACE1 CD5 CD79A CYP19A1

Drugs & Therapeutics for Actinobacillosis

Search Clinical Trials , NIH Clinical Center for Actinobacillosis

Cochrane evidence based reviews: actinobacillosis

Genetic Tests for Actinobacillosis

Anatomical Context for Actinobacillosis

MalaCards organs/tissues related to Actinobacillosis:

40
Tongue

Publications for Actinobacillosis

Articles related to Actinobacillosis:

(show top 50) (show all 61)
# Title Authors PMID Year
1
Vertebral fracture due to Actinobacillus pleuropneumoniae osteomyelitis in a weaner. 61
33176789 2020
2
Diverse strains of Actinobacillus lignieresii isolated from clinically affected cattle in a geographically restricted area. 61
31475335 2019
3
Actinobacillus species isolated from Japanese Thoroughbred racehorses in the last two decades. 61
31292334 2019
4
Atypical actinobacillosis affecting hind limbs and lungs in a single beef cattle herd. 61
30548325 2019
5
Natural lymphatic ("atypical") actinobacillosis in cattle caused by Actinobacillus lignieresii. 61
29202671 2018
6
Factors responsible for the post-slaughter loss of carcass and offal's in abattoirs in South Africa. 61
29224980 2018
7
Multifocal suppurative granuloma caused by Actinobacillus lignieresii in the peritoneum of a beef steer. 61
27773882 2017
8
[Lung and pleural lesions before and after implementation of a national eradication program against enzootic pneumonia and actinobacillosis as well as changes of slaughter carcass organs in slaughter pigs in Switzerland]. 61
26891572 2015
9
A retrospective study of equine actinobacillosis cases: 1999-2011. 61
24742921 2014
10
Atypical cutaneous actinobacillosis in young beef cattle. 61
22915684 2012
11
Rhinitis due to actinobacillosis in a UK suckler cow herd. 61
22550121 2012
12
Field experience with two different vaccination strategies aiming to control infections with Actinobacillus pleuropneumoniae in a fattening pig herd. 61
20334700 2010
13
Ovine genital actinobacillosis: a review. 61
19966895 2009
14
An atypical case of respiratory actinobacillosis in a cow. 61
19687629 2009
15
Use of a chain écraseur for excision of a pharyngeal granuloma in a cow. 61
19335246 2009
16
Pathological changes in accessory sex organs of rams following experimental infection with Actinobacillus seminis. 61
19043470 2008
17
[The seroprevalence of Actinobacillus pleuropneumoniae in Swiss pig breeding herds--a study with the ApxIV ELISA]. 61
18429500 2008
18
Epididymal and testicular lesions in rams following experimental infection with Actinobacillus seminis. 61
17534414 2007
19
Outbreak of actinobacillosis in dairy cows. 61
12974346 2003
20
Atypical actinobacillosis in a dairy replacement herd. 61
12243281 2002
21
Atypical actinobacillosis in a dairy replacement herd. 61
12233835 2002
22
Actinobacillus sp. bacteremia in foals: clinical signs and prognosis. 61
12141310 2002
23
[Actinobacillosis, an old friend found in an unusual place]. 61
12125165 2002
24
Clinical recognition and treatment of bovine cutaneous actinobacillosis. 61
11292088 2001
25
An atypical case of actinobacillosis in a cow. 61
8592894 1995
26
[30 years of the Swine Health Service]. 61
8465177 1993
27
Actinobacillosis in bovine caesarean sections. 61
1462491 1992
28
Actinobacillosis in an alpaca (Lama pacos). 61
16031654 1992
29
Saskatchewan. An outbreak of actinobacillosis in foals. 61
17423968 1992
30
Suspected actinobacillosis manifested by facial enlargement in a heifer. 61
2266054 1990
31
Actinobacillus suis septicemia in mature swine: two outbreaks resembling erysipelas. 61
17423473 1989
32
Saskatchewan. Acute neonatal actinobacillosis in calves. 61
17423379 1989
33
The occurrence of lesions in the tongue of adult cattle and their implications for the development of actinobacillosis. 61
2506716 1989
34
Concurrent infection with Mycobacterium farcinogenes and Actinobacillus lignièresi in slaughtered cattle. 61
3204172 1988
35
Atypical actinobacillosis granulomas in cattle. 61
3371003 1988
36
Suspected cutaneous actinobacillosis in camels. 61
3365176 1988
37
Actinobacillosis in free-ranging snowshoe hares (Lepus americanus) from Alaska. 61
3352090 1988
38
Isolation of Actinobacillus lignieresii from enlarged tongue of a horse. 61
6490508 1984
39
A histological and ultrastructural comparison of the sulfur granule of the actinomycosis and actinobacillosis. 61
7442815 1980
40
Collective outbreaks of bovine actinobacillosis. 61
926504 1977
41
Porcine abortion caused by Actinobacillus equuli. 61
965291 1976
42
Pulmonary diseases of cattle in the Kimberley District of Western Australia. 61
962735 1976
43
Characterization of atypical Actinobacillus lignieresii isolated from ducks with salpingitis and peritonitis. 61
1161454 1975
44
An unusual epizootic of actinobacillosis in dairy heifers. 61
1168181 1975
45
[Actinobacillosis of cattle and sheep]. 61
4838521 1974
46
[Economics of veterinary measures in sheep actinobacillosis]. 61
4784416 1973
47
Septic embolic actinobacillosis of swine: a case report and laboratory reproduction of the disease. 61
5047120 1972
48
Enteric actinobacillosis in calves. 61
5039604 1972
49
[Bovine actinobacillosis of the spermatic cord]. 61
5528593 1970
50
Generalized actinobacillosis in a Holstein cow (postmortem lesions). 61
5201330 1970

Variations for Actinobacillosis

Expression for Actinobacillosis

Search GEO for disease gene expression data for Actinobacillosis.

Pathways for Actinobacillosis

GO Terms for Actinobacillosis

Cellular components related to Actinobacillosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.26 ITGB2 CD79A BACE1 APP
2 integrin alphaL-beta2 complex GO:0034687 8.62 ITGB2 ITGAL

Biological processes related to Actinobacillosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell differentiation GO:0030183 9.33 IL11 CR2 CD79A
2 response to copper ion GO:0046688 9.26 SORD IL1A
3 cellular response to manganese ion GO:0071287 8.96 BACE1 APP
4 regulation of peptidyl-tyrosine phosphorylation GO:0050730 8.8 ITGB2 EGF APP

Molecular functions related to Actinobacillosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ICAM-3 receptor activity GO:0030369 8.62 ITGB2 ITGAL

Sources for Actinobacillosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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