BOIL
MCID: ACT055
MIFTS: 40

Actinomycosis (BOIL)

Categories: Infectious diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Actinomycosis

MalaCards integrated aliases for Actinomycosis:

Name: Actinomycosis 12 76 53 59 44 15 73
Boil 12 76 15
Keratoactinomycosis 53 73
Actinomycetoma 12 73
Canaliculitis 53 73
Madura Foot Due to Actinomadura 12
Anaerobic Actinomyces Infection 53
Actinomycotic Mycetoma of Foot 12
Actinomycotic Madura Foot 12
Actinomycotic Infection 12
Actinomycotic Mycetema 12
Actinomyces Israeli 53
Actinomycetes 53
Furuncle 73

Characteristics:

Orphanet epidemiological data:

59
actinomycosis
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:8478
ICD10 33 A42 A42.9 B47.1
ICD9CM 35 039 039.9
MeSH 44 D000196
NCIt 50 C34350
SNOMED-CT 68 11817007 50508009
Orphanet 59 ORPHA457095
ICD10 via Orphanet 34 A42.8 A42.7 A42.0 more

Summaries for Actinomycosis

Disease Ontology : 12 A commensal bacterial infectious disease that results in infection, which is characterized by contiguous spread, suppurative and granulomatous inflammation, and formation of multiple abscesses and sinus tracts that may discharge sulfur granules, has material basis in Actinomyces israelii, has material basis in Actinomyces gerencseriae, has material basis in Actinomyces naeslundii, has material basis in Actinomyces odontolyticus, has material basis in Actinomyces viscosus, has material basis in Actinomyces meyeri, has material basis in Propionibacterium propionicum, which require a break in the integrity of the mucous membranes and the presence of devitalized tissue to invade deeper body structures.

MalaCards based summary : Actinomycosis, also known as boil, is related to acute canaliculitis and chronic canaliculitis. An important gene associated with Actinomycosis is TMEM79 (Transmembrane Protein 79). The drugs Cetylpyridinium and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include skin, colon and lung, and related phenotype is vision/eye.

NIH Rare Diseases : 53 Actinomycosis is a chronic bacterial infection that commonly affects the face and neck. It is usually caused by an anaerobic bacteria called Actinomyces israelii. Actinomyces are normal inhabitants of the mouth, gastrointestinal tract, and female genital tract, and do not cause an infection unless there is a break in the skin or mucosa. The infection usually occurs in the face and neck, but can sometimes occur in the chest, abdomen, pelvis, or other areas of the body. The infection is not contagious.

Wikipedia : 76 Actinomycosis is a rare infectious bacterial disease caused by Actinomyces species. About 70% of... more...

Related Diseases for Actinomycosis

Diseases related to Actinomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 229)
# Related Disease Score Top Affiliating Genes
1 acute canaliculitis 12.3
2 chronic canaliculitis 12.3
3 cutaneous leishmaniasis 11.5
4 hidradenitis suppurativa 11.5
5 farmer's lung 11.4
6 bagassosis 11.4
7 diarrhea 11.3
8 carbuncle 11.3
9 olecranon bursitis 11.1
10 hordeolum 11.1
11 ventilation pneumonitis 11.0
12 mushroom workers' lung 11.0
13 biotin deficiency 11.0
14 cholera 11.0
15 perichondritis of auricle 11.0
16 prion disease 11.0
17 eumycotic mycetoma 10.4
18 nocardiosis 10.3
19 lung cancer 10.2
20 ovarian cancer 10.2
21 osteomyelitis 10.1
22 appendicitis 10.1
23 mycobacterium chelonae 10.1
24 hydronephrosis 10.1
25 thrombosis 10.1
26 leishmaniasis 10.1
27 papilloma 10.0
28 lymphoma 10.0
29 chromoblastomycosis 10.0
30 ankylosis 10.0
31 pilonidal sinus 10.0
32 aspergillosis 10.0
33 pulmonary aspergilloma 10.0
34 epidural abscess 10.0
35 pneumonia 10.0
36 lymphogranuloma venereum 10.0
37 cryptosporidiosis 10.0
38 hidradenitis 10.0
39 thrombophlebitis 10.0
40 egg allergy 10.0
41 peanut allergy 10.0
42 impetigo 10.0
43 bullous pemphigoid 10.0
44 primary orthostatic tremor 10.0
45 dry eye syndrome 9.9
46 orbital cellulitis 9.9
47 cellulitis 9.9
48 plasmacytoma 9.9
49 meibomian cyst 9.9
50 dacryocystitis 9.9

Graphical network of the top 20 diseases related to Actinomycosis:



Diseases related to Actinomycosis

Symptoms & Phenotypes for Actinomycosis

MGI Mouse Phenotypes related to Actinomycosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 8.92 IL4 RDH11 RERE TMEM79

Drugs & Therapeutics for Actinomycosis

Drugs for Actinomycosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cetylpyridinium Approved Phase 4 7773-52-6
2
Ethanol Approved Phase 4 64-17-5 702
3
Thymol Approved Phase 4 89-83-8 6989
4
Menthol Approved Phase 4 2216-51-5 16666
5
Methyl salicylate Approved, Vet_approved Phase 4 119-36-8 4133
6
Ciclopirox Approved, Investigational Phase 4 29342-05-0 2749
7
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
8
Eucalyptol Approved, Nutraceutical Phase 4 470-82-6 2758
9 Anti-Infective Agents, Local Phase 4,Phase 3,Phase 1,Not Applicable
10 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Not Applicable,Early Phase 1
11 Fluorides Phase 4,Phase 3,Not Applicable
12 Pharmaceutical Solutions Phase 4,Not Applicable
13 Salicylates Phase 4
14 Antifungal Agents Phase 4
15
Triclosan Approved, Investigational Phase 3 3380-34-5 5564
16
BCG vaccine Investigational Phase 3
17 Antimetabolites Phase 3
18
Tin Phase 3 7440-31-5
19 Hypolipidemic Agents Phase 3
20 Cariostatic Agents Phase 3,Not Applicable
21 Protective Agents Phase 3,Not Applicable,Early Phase 1
22 Tin Fluorides Phase 3
23 Lipid Regulating Agents Phase 3
24 Nucleic Acid Synthesis Inhibitors Phase 3
25 Immunologic Factors Phase 3
26 Alkylating Agents Phase 3
27 Antibiotics, Antitubercular Phase 3
28 Anti-Bacterial Agents Phase 3
29 Adjuvants, Immunologic Phase 3
30 Mitomycins Phase 3
31 Vaccines Phase 3
32
Tofacitinib Approved, Investigational Phase 2 477600-75-2
33 Protein Kinase Inhibitors Phase 2
34
Chlorhexidine Approved, Vet_approved Phase 1,Not Applicable 55-56-1 2713 9552079
35 Chlorhexidine gluconate Phase 1,Not Applicable
36 Disinfectants Phase 1
37 Dermatologic Agents Phase 1
38 sodium fluoride Approved Not Applicable 7681-49-4
39 Listerine Not Applicable
40 Antiprotozoal Agents Early Phase 1
41 Proanthocyanidin Early Phase 1
42 Antiparasitic Agents Early Phase 1
43 Anthocyanidin Early Phase 1
44 Antioxidants Early Phase 1
45 Yellow Dock Early Phase 1
46
Procyanidin Early Phase 1 4852-22-6 147299
47 arginine
48 Immunoglobulins
49 Antibodies

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Mouthwashes During Orthodontic Treatment Enrolling by invitation NCT03179735 Phase 4 Essential oils;Cetylpyridinium Chloride 0.7 mg/ml;Placebos
2 Safety Study of Ciclopirox Olamine Cream for Dermatomycoses in Children Terminated NCT01646580 Phase 4 ciclopirox
3 Investigate Oral Bacteria in Adult Population Completed NCT00762177 Phase 3 Fluoride;Fluoride, Triclosan;Stannous Fluoride
4 Adding Mitomycin C to Bacillus of Calmette-Guerin (BCG) as Adjuvant Intravesical Therapy for High-risk, Non-Muscle-invasive Bladder Cancer Recruiting NCT02948543 Phase 3 Mitomycin C (MMC)
5 A Open-Label Study Of CP-690,550 As Long-Term Therapy (48 Weeks) In Subjects With Crohn's Disease Completed NCT01470599 Phase 2 CP-690,550;CP-690,550
6 Chlorhexidine Gel Therapy for Cariogenic Oral Microflora Completed NCT01036412 Phase 1 1% Chlorhexidine Gluconate Gel
7 Oral Hygiene Care and Microflora in Elderly Residents Completed NCT02627469 Not Applicable
8 Oral Hygiene Intervention Pilot Study Completed NCT02668809 Not Applicable
9 Assessment of the Impact of Probiotics on Biofilm Formation on Removable Acrylic Dentures Completed NCT02736994 Not Applicable PIP toothbrush cleaner® (Chrisal, Lommel, Belgium).;Corega Tabs Anti-bacteria®
10 Detection and Characteristic of Whipple Diseases in the Great Britany Completed NCT03350685
11 The Influence of Rumex Acetosa L on the Intraoral Colonization With Porphyromonas Gingivalis Completed NCT02039648 Early Phase 1
12 Interaction Between Immune Cells and Bacteria Associated With Periodontitis Active, not recruiting NCT03225950
13 Assessment of Salivary Bacterial Level and Dental Caries Experience in a Group of Egyptian Children With Black Stained Teeth Not yet recruiting NCT03563469

Search NIH Clinical Center for Actinomycosis

Cochrane evidence based reviews: actinomycosis

Genetic Tests for Actinomycosis

Anatomical Context for Actinomycosis

MalaCards organs/tissues related to Actinomycosis:

41
Skin, Colon, Lung, Bone, Liver, Breast, Appendix

Publications for Actinomycosis

Articles related to Actinomycosis:

(show top 50) (show all 1140)
# Title Authors Year
1
Actinomycosis of tongue: Rare presentation mimicking malignancy with literature review and imaging features. ( 30425772 )
2019
2
Actinomycosis ( 29489261 )
2018
3
Pulmonary actinomycosis mimicking a lung metastasis from esophageal cancer; a case report. ( 29486747 )
2018
4
Chronic Madura foot: mycetoma and/or <i>Actinomyces</i> spp or actinomycosis. ( 29789306 )
2018
5
Refractory actinomycosis of the humerus. ( 29348917 )
2018
6
Brain abscess caused by chronic invasive actinomycosis in the nasopharynx: A case report and literature review. ( 29668598 )
2018
7
A case of esophageal actinomycosis with a unique morphology presenting as a refractory ulcer. ( 29124648 )
2018
8
Actinomycosis of Distal Phalanx Twenty Years after Flap Reconstruction of Index Finger: A Case Report. ( 29725514 )
2018
9
Central Nervous System Actinomycosis-A Clinicoradiologic and Histopathologic Analysis. ( 29751182 )
2018
10
Rapid Bone Healing after Intentional Replantation of a Molar with Apical Actinomycosis. ( 29692850 )
2018
11
Wolf in Sheep's clothing: Intracranial actinomycosis masquerading as <i>en-plaque</i> meningioma. ( 29527397 )
2018
12
Nasal Cavity Actinomycosis Mimicking Rhinolith. ( 29461370 )
2018
13
Cervicofacial actinomycosis can obscure a malignancy: A case report. ( 29548682 )
2018
14
Pulmonary actinomycosis masquerading as lung cancer: keep it in mind. ( 29423982 )
2018
15
&amp;quot;Pulmonary Actinomycosis attributable to <i>Actinomyces meyeri</i> presenting as cardiac tamponade: a case report&amp;quot;. ( 29946465 )
2018
16
Actinomycosis, a lurking threat: a report of 11 cases and literature review. ( 29513846 )
2018
17
Hepatic actinomycosis with immunoglobulin G4-related liver disease: A case report. ( 29901644 )
2018
18
Intraabdominal actinomycosis resulting in a difficult to diagnose intraperitoneal mass: A case report. ( 29604528 )
2018
19
Retraction: Thoracic Vertebral Actinomycosis Secondary to a Pulmonary Origin. ( 29383289 )
2018
20
Intraabdominal and Pelvic actinomycosis in association with posterior reversible encephalopathy syndrome (PRES): A case report. ( 29758229 )
2018
21
Actinomyces meyeri: A Rare Cause of Postsurgical Pelvic Actinomycosis. ( 30034893 )
2018
22
Rare Case of Male Pelvic Actinomycosis. ( 30039030 )
2018
23
Actinomycosis: An infrequent disease in renal transplant recipients? ( 30055044 )
2018
24
Severe abdominopelvic actinomycosis with colon perforation and hepatic involvement mimicking advanced sigmoid colon cancer with hepatic metastasis: a case study. ( 30068330 )
2018
25
Rare Abdominopelvic Actinomycosis Causing an Intestinal Band Obstruction and Mimicking an Ovarian Malignancy. ( 30079287 )
2018
26
Comment on "Intra-abdominal actinomycosis resulting in a difficult-to-diagnose intraperitoneal mass: A case study report''. ( 30087029 )
2018
27
Actinomycosis-induced adnexal and uterine masses mimicking malignancy on FDG PET/CT. ( 30096319 )
2018
28
Reply to comment on "Intra-abdominal actinomycosis resulting in a difficult-to-diagnose intraperitoneal mass: A case study report". ( 30100171 )
2018
29
Actinomycosis-induced Trismus with Orbital Involvement. ( 30101938 )
2018
30
Orbital and Pulmonary Actinomycosis: The First Case Report and Literature Review. ( 30147972 )
2018
31
Masking and misleading: concomitant actinomycosis and B-cell lymphoma - a case report and review of literature. ( 30165794 )
2018
32
Treatment of penile actinomycosis. ( 30182465 )
2018
33
Pulmonary actinomycosis diagnosed by transbronchoscopic lung biopsy: A case report and literature review. ( 30186488 )
2018
34
Pancreatic Actinomycosis. ( 30187330 )
2018
35
"Holes" in the Jaw-A Report of Two Cases of Periapical Actinomycosis. ( 30200654 )
2018
36
Disseminated Actinomycosis. ( 30207906 )
2018
37
Is appendectomy always adequate for treatment?: Clinical manifestations of isolated actinomycosis in the appendix. ( 30216180 )
2018
38
Actinomyces denticolens as a causative agent of actinomycosis in animals. ( 30224576 )
2018
39
Actinomycosis Presenting as Macroglossia: Case Report and Review of Literature. ( 30244331 )
2018
40
A case of thoracic actinomycosis presenting as sudden paraplegia. ( 30309660 )
2018
41
Atypical Form of Cervicofacial Actinomycosis Involving the Skull Base and Temporal Bone. ( 30371104 )
2018
42
Intracranial Actinomycosis Presenting As A Parenchymal Mass Lesion: A Case Report And Review Of Literature. ( 30391617 )
2018
43
Splendore-Hoeppli phenomenon in a fine needle aspirate of cervicofacial actinomycosis. ( 30488615 )
2018
44
Actinomycosis of the Middle Ear and Mastoid. ( 30514999 )
2018
45
Non-invasive diagnosis of cutaneous leishmaniasis by the direct boil loop-mediated isothermal amplification method and MinION™ nanopore sequencing. ( 28288843 )
2018
46
Recovery of Surgical Equipment Sterile Processing During a Floodwater Boil Advisory. ( 28803582 )
2018
47
To Boil an Egg: Substrate Binding Affects Critical Stability in Thermal Unfolding of Proteins. ( 29401389 )
2018
48
"We Boil at Different Degrees": Factors Associated With Severity of Attack in Sexual Killing. ( 29502505 )
2018
49
The Boil Test-Strategies for Resistance Determination of Microorganisms. ( 29954922 )
2018
50
Pulmonary Actinomycosis Mimicking Pulmonary Aspergilloma and a Brief Review of the Literature. ( 28202870 )
2017

Variations for Actinomycosis

Expression for Actinomycosis

Search GEO for disease gene expression data for Actinomycosis.

Pathways for Actinomycosis

GO Terms for Actinomycosis

Sources for Actinomycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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