BOIL
MCID: ACT055
MIFTS: 55

Actinomycosis (BOIL)

Categories: Gastrointestinal diseases, Infectious diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Actinomycosis

MalaCards integrated aliases for Actinomycosis:

Name: Actinomycosis 12 74 20 58 44 15 17 71 32
Actinomycetoma 12 71 32
Keratoactinomycosis 20 71
Canaliculitis 20 71
Boil 12 74
Madura Foot Due to Actinomadura 12
Anaerobic Actinomyces Infection 20
Actinomycotic Mycetoma of Foot 12
Actinomycotic Madura Foot 12
Actinomycotic Infection 12
Actinomycotic Mycetema 12
Actinomyces Israeli 20
Actinomycetes 20
Furuncle 71

Characteristics:

Orphanet epidemiological data:

58
actinomycosis
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:8478
ICD9CM 34 039.9
MeSH 44 D000196
NCIt 50 C34350
SNOMED-CT 67 50508009
ICD10 32 A42 A42.9 B47.1
ICD10 via Orphanet 33 A42.0 A42.1 A42.2 more
Orphanet 58 ORPHA457095
UMLS 71 C0001261 C0242301 C0423172 more

Summaries for Actinomycosis

GARD : 20 Actinomycosis is a bacterial infection that occurs most often in the face and neck. Symptoms of actinomycosis include a neck mass, jaw or face pain, and formation of pockets of pus (abscess). When actinomycosis occurs in other parts of the body, symptoms can include cough, chest or stomach pain, fever, and weight loss. It is usually caused by bacteria called Actinomyces israelii. These bacteria are found normally in the mouth, gastrointestinal tract, and female genital tract, and do not cause an infection unless there is a break in the skin or mucosa. The infection is not contagious. Actinomycosis is diagnosed based on the history and clinical exam, and through specific laboratory tests. It is treated with antibiotics.

MalaCards based summary : Actinomycosis, also known as actinomycetoma, is related to bagassosis and cholera. An important gene associated with Actinomycosis is H2AC18 (H2A Clustered Histone 18), and among its related pathways/superpathways are Innate Immune System and Allograft rejection. The drugs Metronidazole and Budesonide have been mentioned in the context of this disorder. Affiliated tissues include colon, tongue and skin, and related phenotypes are cardiovascular system and immune system

Disease Ontology : 12 A commensal bacterial infectious disease that results in infection, which is characterized by contiguous spread, suppurative and granulomatous inflammation, and formation of multiple abscesses and sinus tracts that may discharge sulfur granules, has material basis in Actinomyces israelii, has material basis in Actinomyces gerencseriae, has material basis in Actinomyces naeslundii, has material basis in Actinomyces odontolyticus, has material basis in Actinomyces viscosus, has material basis in Actinomyces meyeri, has material basis in Propionibacterium propionicum, which require a break in the integrity of the mucous membranes and the presence of devitalized tissue to invade deeper body structures.

Wikipedia : 74 Actinomycosis is a rare infectious bacterial disease caused by Actinomyces species. About 70% of... more...

Related Diseases for Actinomycosis

Diseases related to Actinomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1083)
# Related Disease Score Top Affiliating Genes
1 bagassosis 31.9 TNF IL6 IL1B
2 cholera 31.4 TNF INS IL6 IL4 IL1B
3 nocardiosis 31.2 TNF CRP CD4
4 pleural empyema 31.1 IL6 CRP CD4 ALB
5 appendicitis 30.9 TNF IL6 IL1B CRP ALB
6 diverticulitis 30.8 TNF IL6 CRP ALB
7 extrinsic allergic alveolitis 30.7 IL6 IL1B FN1 ALB
8 osteomyelitis 30.7 TNF IL6 IL4 IL1B CRP
9 epidural abscess 30.7 CRP CD4 ALB
10 pericarditis 30.5 TNF IL6 IL1B CRP
11 pulmonary tuberculosis 30.5 TNF IL6 IL4 ALB
12 intestinal obstruction 30.5 IL6 CRP ALB
13 urinary tract obstruction 30.5 FN1 CRP ALB
14 pericardial effusion 30.5 IL6 CRP CD68 CD4 ALB
15 splenic abscess 30.5 CRP CD4 ALB
16 disease by infectious agent 30.4 TNF IL6 IL4 IL1B H2AC18 CRP
17 bacterial conjunctivitis 30.4 TNF IL6 IL1B CRP ALB
18 mediastinitis 30.4 INS CRP CD4 ALB
19 aspergillosis 30.4 TNF IL6 IL4 IL1B
20 leishmaniasis 30.4 TNF IL6 IL4 IL1B
21 mucormycosis 30.4 INS CRP CD4 ALB
22 constipation 30.4 INS IL6 CRP ALB
23 bronchiectasis 30.4 TNF IL6 IL1B CRP
24 lung abscess 30.4 TNF IL6 IL1B CRP CD4 ALB
25 tonsillitis 30.4 TNF IL6 IL4 IL1B
26 pyelonephritis 30.4 TNF IL6 IL1B CRP ALB
27 chronic conjunctivitis 30.4 TNF IL6 IL4 IL1B CD4
28 xanthogranulomatous pyelonephritis 30.3 CRP CD68
29 salpingitis 30.3 TNF IL6 CRP CD4
30 thrombocytosis 30.3 IL6 IL1B CRP ALB
31 cutaneous leishmaniasis 30.3 TNF IL6 IL4 IL1B
32 allergic disease 30.3 TNF IL6 IL4 IL1B
33 peritonitis 30.3 TNF IL6 IL4 IL1B CRP ALB
34 candidiasis 30.3 TNF IL6 IL4 IL1B
35 endometritis 30.3 TNF IL6 IL1B
36 cholelithiasis 30.2 INS CRP ALB
37 pancreatitis 30.2 TNF INS IL6 IL1B CRP
38 periodontitis, chronic 30.2 IL6 IL1B
39 duodenal ulcer 30.2 TNF INS IL6 IL1B
40 ileus 30.1 TNF INS IL6 IL1B CRP
41 stachybotrys chartarum 30.1 TNF IL6 IL1B
42 disseminated intravascular coagulation 30.1 TNF IL6 FN1 CRP
43 mycobacterium tuberculosis 1 30.1 TNF IL4 H2AC18 CD4
44 erysipelas 30.1 TNF IL6 IL1B CRP
45 peptic ulcer perforation 30.1 CRP ALB
46 periodontitis 30.1 TNF IL6 IL4 IL1B CRP
47 cellulitis 30.1 TNF INS IL6 CRP CD4 ALB
48 gastric ulcer 30.1 TNF IL6 IL1B
49 vaginal discharge 30.1 TNF IL6 IL1B CRP CD4 ALB
50 pemphigoid 30.1 TNF IL4 IL1B

Graphical network of the top 20 diseases related to Actinomycosis:



Diseases related to Actinomycosis

Symptoms & Phenotypes for Actinomycosis

MGI Mouse Phenotypes related to Actinomycosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.9 ACTB ALB CRP FN1 GAPDH IL1B
2 immune system MP:0005387 9.73 ACTB ALB CD4 CD68 CRP FN1
3 liver/biliary system MP:0005370 9.28 ACTB ALB FN1 GAPDH IL4 IL6

Drugs & Therapeutics for Actinomycosis

Drugs for Actinomycosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 156)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metronidazole Approved Phase 4 443-48-1 4173
2
Budesonide Approved Phase 4 51333-22-3 63006 5281004
3 Anti-Infective Agents Phase 4
4 Hawthorn Phase 4
5 Antiparasitic Agents Phase 4
6 Antiprotozoal Agents Phase 4
7 Bitter Melon Phase 4
8
BCG vaccine Approved, Investigational Phase 3
9
Adalimumab Approved, Experimental Phase 3 331731-18-1 16219006
10
Caffeine Approved Phase 3 58-08-2 2519
11
Tibolone Approved, Investigational Phase 3 5630-53-5
12
Ambroxol Approved, Investigational Phase 3 18683-91-5
13
acetic acid Approved Phase 3 64-19-7 176
14
Turmeric Approved, Experimental, Investigational Phase 3
15
Calcium carbonate Approved, Investigational Phase 3 471-34-1
16
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
17 Prednisolone acetate Approved, Vet_approved Phase 2, Phase 3 52-21-1
18
Methylprednisolone hemisuccinate Approved Phase 2, Phase 3 2921-57-5
19
Prednisolone phosphate Approved, Vet_approved Phase 2, Phase 3 302-25-0
20
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
21
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
22
Ethanol Approved Phase 2, Phase 3 64-17-5 702
23
Uric acid Investigational Phase 2, Phase 3 69-93-2 1175
24
Prednisolone hemisuccinate Experimental Phase 2, Phase 3 2920-86-7
25 Mitomycins Phase 3
26 Phosphodiesterase Inhibitors Phase 3
27 Central Nervous System Stimulants Phase 3
28 Neurotransmitter Agents Phase 3
29 Respiratory System Agents Phase 3
30 Expectorants Phase 3
31 Turmeric extract Phase 3
32 Anti-Inflammatory Agents Phase 2, Phase 3
33 Antirheumatic Agents Phase 2, Phase 3
34 Immunologic Factors Phase 2, Phase 3
35 Hormone Antagonists Phase 2, Phase 3
36 Astragalus Phase 2, Phase 3
37 glucocorticoids Phase 2, Phase 3
38 Methylprednisolone Acetate Phase 2, Phase 3
39 Chinese Rhubarb Phase 2, Phase 3
40 Hormones Phase 2, Phase 3
41 Hypoglycemic Agents Phase 2, Phase 3
42 Immunoglobulin A Phase 2, Phase 3
43 Alkylating Agents Phase 2, Phase 3
44 Antineoplastic Agents, Hormonal Phase 2, Phase 3
45 Insulin, Globin Zinc Phase 2, Phase 3
46 insulin Phase 2, Phase 3
47 Immunosuppressive Agents Phase 2, Phase 3
48 Dong Quai Phase 2, Phase 3
49 Angelica Phase 2, Phase 3
50 Angiotensin-Converting Enzyme Inhibitors Phase 2, Phase 3

Interventional clinical trials:

(show top 50) (show all 72)
# Name Status NCT ID Phase Drugs
1 The Efficacy and Safety Study of Honghe Fujie Lotion for the Treatment of Bacterial Vaginosis Unknown status NCT03446443 Phase 4 Honghe Fujie lotion;Metronidazole Suppositories
2 Steroid Nasal Irrigation for Flavor Evaluation and Detection (SNIFFED) Study Completed NCT02985515 Phase 4
3 Randomized, Controlled Crossover Trial to Evaluate the Effects of Ambulatory Oxygen on Health Status in Patients With Fibrotic Lung Disease (FLD). Completed NCT02286063 Phase 4 Ambulatory Oxygen
4 The Differentiation and Treatment Scheme of TCM Key Syndromes for the Treatment of Acute Disabling Ischemic Stroke: a Randomized, Double-Blind, Placebo-Controlled Multicenter Trial Recruiting NCT04199455 Phase 4 Integrative Treatment (EPACH Recipe Granules + NQABC Recipe Granules);Placebo
5 Adding Mitomycin C to Bacillus of Calmette-Guerin (BCG) as Adjuvant Intravesical Therapy for High-risk, Non-Muscle-invasive Bladder Cancer: a Randomised Phase 3 Trial Unknown status NCT02948543 Phase 3 Mitomycin C (MMC)
6 A Phase 3 Multicenter Study of the Safety and Efficacy of Adalimumab in Subjects With Moderate to Severe Hidradenitis Suppurativa - PIONEER II Completed NCT01468233 Phase 3
7 A Phase 3 Multicenter Study of the Safety and Efficacy of Adalimumab in Subjects With Moderate to Severe Hidradenitis Suppurativa - PIONEER I Completed NCT01468207 Phase 3
8 Effects of Caffeine and Coffee on Resting Metabolic Rate, Comparing Normal Weight Men to Obese Men Completed NCT02751840 Phase 3
9 Efficacy and Safety of Combined Treatment of Herbs and TCM Emotion Treatment for Women With Menopausal Syndrome: A Multiple-centered Randomized Controlled Trial Completed NCT00933725 Phase 3
10 A Randomised, Double-blind, Placebo Controlled, Parallel Group, Multicentre Trial to Assess the Efficacy and Safety of Ambroxol Lozenges 20 mg (Hard Boiled Lozenges) Versus Placebo for the Relief of Sore Throat Pain in Patients With Acute Pharyngitis Completed NCT03583658 Phase 3 ambroxol BIH1526;placebo
11 A Double-blind, Randomized, Two-dose Trial of Tumor-shrinking Decoction (TSD), a Chinese Medicine Preparation in Patients With Symptomatic Uterine Fibroids Completed NCT02189083 Phase 3 TSD
12 Treatment Effects of Chinese Medicine (Yi-Qi-Qing-Jie Herbal Compound) Combined With Immunosuppression Therapies in IgA Nephropathy Patients With High-risk of End-stage Renal Disease (TCM-WINE) Recruiting NCT03418779 Phase 2, Phase 3 The Yi-Qi-Qing-Jie herbal compound;Immunosuppressants
13 Efficacy, Safety and Response Predictors of Adjuvant Astragalus Therapy for Diabetic Kidney Disease (READY) - An Open-label Randomised Controlled Trial With Responder Regression Analysis Recruiting NCT03535935 Phase 2, Phase 3 Astragalus Powder
14 "973" Project for Pathology of Traditional Chinese Medicine Unknown status NCT00569088 Phase 2 Chinese herbs formula;Mannitol
15 A Double-blind,Placebo-controlled, Randomized, Crossover Trial of Mint Tea High in Rosmarinic Acid in Adults With Nasal Polyposis Completed NCT00465543 Phase 2
16 The Effects of Lactulose Supplementation to Enteral Feedings in Premature Infants - A Pilot Study Completed NCT00616876 Phase 2 Lactulose
17 The Herbal Medicine Peony-Glycyrrhiza Decoction (PGD) as an Adjunctive Therapy to Treat Antipsychotic-induced Hyperprolactinemia in Patients With Schizophrenia: a Double-blind, Randomized, Placebo-controlled Study Completed NCT01852331 Phase 2 PGD granules;Placebo
18 Laxative Effectiveness of a Phytotherapeutic Tea: A Randomized Placebo-Controlled Clinical Trial Completed NCT00872430 Phase 2
19 The Effects of a Very Low Carbohydrate Diet Intervention on Weight Control in Overweight/Obese Patients in China Completed NCT02283151 Phase 2
20 Multi-center, Randomized, Double Blind and Placebo Controlled Clinical Trial on the Effectiveness and Safety of Jinhua Qinggan Granules (JHQG) for the Treatment of COVID 19 Patients Recruiting NCT04723524 Phase 2
21 Oral Chinese Herbal Medicine for Psoriasis Vulgaris With Blood Heat Syndrome: a Randomised, Double-blind, Doubledummy, Multicentre Clinical Trial Not yet recruiting NCT03961230 Phase 2 Jueyin granules;Jueyin Granules Placebo
22 Oral Chinese Herbal Medicine for Psoriasis Vulgaris With Blood Stasis Syndrome: a Randomised, Double-blind, Doubledummy, Multicentre Clinical Trial Not yet recruiting NCT03942198 Phase 2 Taodan Granules;Taodan Granules Placebo
23 Buqitongluo Granule for Qi Deficiency and Blood Stasis Syndrome: A Multicenter, Randomized, Double-blind, Placebo-Controlled Trial Not yet recruiting NCT04408261 Phase 2 Buqitongluo Granule;Buqitongluo Granule Placebo
24 Use of Maytenus Ilicifolia Mart. ex Reiss in the Treatment of Dyspepsia Terminated NCT01408849 Phase 2 Maytenus ilicifolia leaves infusion;Omeprazole
25 Feed-Back Suppression of Meal-Induced GLP-1 Secretion Mediated Through Elevations in Intact GLP-1 Caused by Dipeptidyl Peptidase 4 (DPP-4) Inhibition: A Randomized, Prospective Comparison of Sitagliptin and Vildagliptin Treatment Completed NCT02749032 Phase 1 Vildagliptin;Sitagliptin;Placebo;Metformin
26 A Single Dose, Open Label, Randomized Scintigraphic Study to Investigate the Gastrointestinal Behavior of 2 Triple Combination Products (Acetaminophen, Phenylephrine and Dextromethorphan) in Healthy Male Volunteers Completed NCT03415243 Phase 1 Acetaminophen 650mg+Dextromethorphan 20mg+Phenylephrine 10mg;Acetaminophen 325mg+Dextromethorphan 10mg+Phenylephrine 5mg
27 Boiled Peanut Oral Immunotherapy for the Treatment of Peanut Allergic Pediatric Patients Enrolling by invitation NCT04090203 Phase 1 Boiled Peanut Powder
28 A Phase Ib Placebo-controlled Study to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SY-008 After Multiple Ascending Doses in Patients With Type 2 Diabetes Mellitus Not yet recruiting NCT04345120 Phase 1 SY-008;SY-008 matching placebo
29 A Phase Ib Placebo-controlled Study to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SY-009 After Multiple Ascending Doses in Patients With Type 2 Diabetes Mellitus Not yet recruiting NCT04345107 Phase 1 SY-009;SY-009 matching placebo
30 Immunologic Response to Euphorbia Kansui Extract Powder Prepared as Tea in HIV-infected Antiretroviral Therapy (ART)-Suppressed Individuals: a Dose Escalation Study Suspended NCT02531295 Phase 1 Euphorbia kansui extract powder prepared as tea
31 The Study of TCM in Prevention and Promote of Community-based Diabetes Unknown status NCT01471275 Metformin;Jiangtangtiaozhi decoction
32 Improving Nutrition and Health Outcomes in Intibuca, Honduras Unknown status NCT01303016
33 Assessment of the Effect of n-3(Omega 3) Fortified Egg Compared to Omega-6 Israeli Regular Egg on Metabolic, Inflammation and Other Physiologic Parameters Prospective, Crossover, Compared Study in Healthy Subjects Unknown status NCT01565252
34 Effect of Enteral Albumin on Healing of Superficial Partial Thickness Fresh Flame Burns of Adults Unknown status NCT03709069
35 A Randomized Clinical Trial Comparing Use of Rapid Molecular Testing for Staphylococcus Aureus for Patients With Cutaneous Abscesses in the Emergency Department With Standard of Care. Completed NCT01523899
36 Efficacy of Yellow Cassava to Improve Vitamin A Status of Mildly Deficient Primary School Children in Kenya: a Randomized Controlled Trial Completed NCT01614483
37 Effect of Treatment Nutritional With Supplementation About Biochemical Profile and Anthropometry in Adult Patients With HIV/AIDS Completed NCT02180035
38 Biomarkers of Meats and Potatoes Intake: a Meal Study in Healthy Men and Women - the MEPO Study Completed NCT04548362
39 Efficacy of Standardized Brooke Bond Black Tea Extract on Flow-Mediated Dilation After an Acute Dose as Well as After One Week of Consumption in Healthy Adult Indian Males Completed NCT01561300
40 Safety and Efficacy of a Complex Herbal Tea Mixture in Type 2 Diabetics Completed NCT04054284
41 Influence of Resistant Starch in Baked and Boiled Potatoes on Glycemic and Satiety Responses in Overweight Females Completed NCT03310476
42 Cooking With Iron Ingots: Assessing Feasibility and Natural History Among Infants in Resource-limited Settings Completed NCT03606993
43 Senna Alata Leaf Decoction as a Treatment for Tinea Imbricata in an Indigenous Tribe in Southern Philippines :a Pilot Study Completed NCT03745183
44 A Randomized Placebo-compared Study on Efficiency of Two Different Administration Forms of Phyllanthus Niruri and Sida Cordifolia in Patients With Diabetic Peripheral Polyneuropathy Completed NCT02107469 Sida cordifolia roots;Phyllanthus niruri;Sida cordifolia roots extract;Phyllanthus niruri extract
45 Identification of the Antiplatelet Compounds of Garlic Ex Vivo Completed NCT00200785
46 The Effects of Daily Ginger Tea Consumption in Reducing Discomfort During Menstruation Completed NCT03300999
47 Post-prandial Glucose and Insulin Levels in Type 2 Diabetes Mellitus Patients After Consumption of Ready-to-eat Mixed Meals Completed NCT02543684
48 The Effectiveness of the Neutropenic Diet in Pediatric Oncology Patients Completed NCT00726934
49 Evaluation of a Polymeric Plate Derived From Castor Oil to Thermotherapy Completed NCT01100541
50 Flavonoid Effect on Activation and Stimulation of Thrombocytes, hsCRP and Lipid Profile Completed NCT00559663

Search NIH Clinical Center for Actinomycosis

Cochrane evidence based reviews: actinomycosis

Genetic Tests for Actinomycosis

Anatomical Context for Actinomycosis

MalaCards organs/tissues related to Actinomycosis:

40
Colon, Tongue, Skin, Breast, Appendix, Kidney, Thyroid

Publications for Actinomycosis

Articles related to Actinomycosis:

(show top 50) (show all 4489)
# Title Authors PMID Year
1
Cervicofacial actinomycosis following third molar removal: case-series and review. 61
32820354 2021
2
Pathologist-performed palpation-guided fine needle aspiration cytology of lingual actinomycosis: A case report and review of literature. 61
32936539 2021
3
Mycetoma imaging: the best practice. 61
33537774 2021
4
Ectopic mediastinal thyroid removed by U-VATS approach. A case report. 61
33373924 2021
5
Actinomyces in explanted transvaginal mesh: commensal or pathogen? 61
33416964 2021
6
Mesenteric actinomycosis 61
33459607 2021
7
Deep mycoses and pseudomycoses of the foot: a single-center retrospective study of 160 cases, in a tertiary-care center in Mexico. 61
33453613 2021
8
Case Report: Coral Reef Pathogen Aspergillus sydowii Causing Black Grain Mycetoma: A Review. 61
33399044 2021
9
Mycetoma caused by Microascus gracilis: a novel agent of human eumycetoma in Sudan. 61
33515449 2021
10
Actinomycetoma laboratory-based diagnosis: a mini-review. 61
33449118 2021
11
The challenges of recruitment in clinical trials in developing countries: the Mycetoma Research Centre experience. 61
33484566 2021
12
Extensive perineal Actinomadura pelletieri actinomycetoma-induced urethral stricture: a rare complication. 61
33399848 2021
13
Rectal actinomycosis mimicking malignancy. 61
33461413 2021
14
Pulmonary Actinomycosis in South Australian Koalas (Phascolarctos cinereus). 61
33461422 2021
15
[Pulmonary actinomycosis in children: a case report and literature review]. 61
33397001 2021
16
Abdominal Actinomycosis After Bariatric Surgery. 61
32557388 2021
17
Hypertrophic osteopathy in South Australian koalas (Phascolarctos cinereus) with concurrent pulmonary actinomycosis. 61
33501661 2021
18
Mimicking uterine malignancy: Pelvic actinomycosis with giant uterine leiomyoma. 61
33294369 2021
19
Image screening for maxillo-mandibular actinomycosis with CT, 18F-FDG-PET/CT, and 18F-α-methyl tyrosine PET/CT. 61
31925626 2021
20
Orofacial soft tissues actinomycosis: A retrospective, 10-year single-institution experience. 61
33384821 2021
21
A rare cause of dysphagia: gastro-esophageal junction actinomycosis diagnosed with endoscopic ultrasound. 61
33259384 2021
22
A Decade Old Case of Actinomycetoma Evading «Diagnosis». 61
33373594 2020
23
Actinomycetoma with systemic features: A warning sign for immunosuppression? 61
33270626 2020
24
Abdominopelvic Actinomycosis Mimicking Peritoneal Carcinomatosis: A Case Report. 61
32054258 2020
25
Actinomyces in Forensic Practice. 61
33346982 2020
26
Role of bronchoalveolar lavage in diagnosing pulmonary infections and malignancies: Experience from a tertiary care center. 61
32770787 2020
27
Pulmonary Actinomycosis Mimicking Pulmonary Cancer on Fluorine-18 Fluorodeoxyglucose PET-CT. 61
33520505 2020
28
Hepatobiliary Actinomycosis, a Rare Presentation of a Rare Disease! 61
33542863 2020
29
[Atypical actinomycosis revealed by distant dermatological disorders: Report of an unusual case and literature review]. 61
33303221 2020
30
Imaging of disseminated actinomycosis. 61
33288490 2020
31
A very rare case of possible actinomycosis of the mandible from the Middle Ages. 61
32949891 2020
32
Abdominopelvic Actinomycosis Mimicking a Malignant Ovarian Neoplasia: Case Report and Review of Literature. 61
33489593 2020
33
Cyto-morphological and clinical approach to infections presenting with discharging sinuses mimicking malignancy. 61
33460244 2020
34
Human actinomycetoma caused by Actinomadura mexicana in Sudan: the first report. 61
33382899 2020
35
Molecular identification of Actinomadura madurae isolated from a patient originally from Algeria; observations from a case report. 61
33176717 2020
36
Hidradenitis suppurativa associated with actinomycosis owing to Actinomyces meyeri. 61
33140414 2020
37
Intracranial Mycotic Aneurysm in a Patient with Abdominal Actinomycosis. 61
33220485 2020
38
Actinomycosis: A rare etiology of chronic appendicitis in elderly. 61
32800856 2020
39
A Case of Actinomycosis in the Rosenmüller's Fossa. 61
33236645 2020
40
Pulmonary actinomycosis diagnosed by radial endobronchial ultrasound coupled with metagenomic next-generation sequencing: A case report and brief literature review. 61
32979589 2020
41
A disease disregards anatomical planes: actinomycosis and an intrauterine device. 61
33248498 2020
42
Actinomycetoma caused by Nocardia asiatica associated with traditional Chinese medicine foot bath. 61
33089495 2020
43
Cervicofacial actinomycosis: a report of 14 patients observed at the Dermatology Unit of the University of Milan, Italy. 61
32403186 2020
44
Cervicofacial actinomycosis. 61
32162331 2020
45
Inducible nitric oxide synthase blockade with aminoguanidine, protects mice infected with Nocardia brasiliensis from actinomycetoma development. 61
33091049 2020
46
Suppurative cervical lymphadenitis in adult: An analysis of predictors for surgical drainage. 61
32370913 2020
47
Pelvic actinomycosis presenting as a single episode of postmenopausal bleeding in a 60-year-old woman whose intrauterine contraceptive device had been removed 10 years previously: A case report. 61
33145181 2020
48
Pulmonary Sequestration Associated with Actinomycosis: A Case Report. 61
33050328 2020
49
Disseminated Pelvic Actinomycosis Caused by Actinomyces Naeslundii. 61
33137889 2020
50
Pelvic actinomycosis: a forgotten cause of pelvic pain. 61
33135910 2020

Variations for Actinomycosis

Expression for Actinomycosis

Search GEO for disease gene expression data for Actinomycosis.

Pathways for Actinomycosis

Pathways related to Actinomycosis according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 TNF PECAM1 OSTF1 INS IL6 IL4
2
Show member pathways
12.78 TNF INS IL6 IL4 IL1B CD4
3
Show member pathways
12.73 TNF IL6 IL1B GAPDH ACTB
4
Show member pathways
12.6 TNF IL6 IL4 IL1B CD4
5
Show member pathways
12.59 TNF IL6 IL4 IL1B CD4
6
Show member pathways
12.58 TNF IL6 IL1B FN1 CD4
7
Show member pathways
12.32 TNF IL6 IL4 IL1B
8
Show member pathways
12.26 TNF POLR2B IL6 IL4 IL1B
9 12.18 TNF IL6 IL1B GAPDH
10
Show member pathways
12.14 TNF IL6 IL4 IL1B FN1
11 12.08 TNF PECAM1 IL1B ACTB
12 12 TNF IL6 IL4 IL1B
13 11.93 INS IL6 IL1B FN1
14 11.91 TNF IL6 IL1B FN1
15 11.9 TNF IL6 IL4 CD68 CD4
16 11.89 TNF IL6 IL1B FN1
17 11.86 TNF IL6 IL4 IL1B FN1
18
Show member pathways
11.84 IL6 IL4 IL1B CD4
19
Show member pathways
11.83 TNF INS IL6 IL4 IL1B CRP
20 11.78 TNF IL4 IL1B CD4
21 11.77 TNF IL6 IL1B FN1 CD4 ACTB
22 11.76 TNF IL6 IL4 IL1B CD4
23 11.75 TNF IL6 IL1B
24
Show member pathways
11.75 TNF IL6 IL1B CD4
25 11.73 TNF IL6 IL1B CD4
26 11.68 TNF IL6 IL4
27
Show member pathways
11.65 TNF IL6 IL1B
28 11.64 TNF IL6 IL4 IL1B
29 11.61 TNF IL6 IL1B
30 11.53 TNF IL1B ACTB
31 11.53 TNF IL6 FN1
32 11.49 TNF IL6 IL1B
33 11.48 TNF PECAM1 IL6 IL1B
34 11.45 TNF IL6 IL4 IL1B
35 11.42 PECAM1 FN1 ACTB
36 11.37 TNF IL6 IL1B
37 11.34 TNF IL6 IL1B
38 11.28 TNF IL6 IL1B
39 11.13 TNF IL6 IL4 IL1B
40 10.93 TNF IL1B CD68
41 10.84 TNF IL6 FN1 CRP
42 10.77 IL6 IL4 IL1B
43 10.48 TNF IL6 IL4 IL1B CD4

GO Terms for Actinomycosis

Cellular components related to Actinomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.36 TNF PECAM1 LGALS4 INS IL6 IL4
2 endoplasmic reticulum lumen GO:0005788 9.35 INS IL6 FN1 CD4 ALB

Biological processes related to Actinomycosis according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.92 INS IL6 FN1 ALB
2 positive regulation of protein phosphorylation GO:0001934 9.9 TNF PECAM1 IL1B CD4
3 cellular response to lipopolysaccharide GO:0071222 9.86 TNF IL6 IL1B CD68
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.84 TNF INS IL6 IL1B
5 regulation of insulin secretion GO:0050796 9.8 TNF IL6 IL1B
6 cytokine-mediated signaling pathway GO:0019221 9.8 TNF IL6 IL4 IL1B FN1 CD4
7 positive regulation of gene expression GO:0010628 9.8 TNF INS IL6 IL4 IL1B FN1
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.79 TNF IL6 IL4
9 glucose metabolic process GO:0006006 9.77 TNF INS GAPDH
10 positive regulation of interleukin-8 production GO:0032757 9.76 TNF IL6 IL1B
11 positive regulation of cytokine production GO:0001819 9.75 TNF INS GAPDH
12 positive regulation of T cell proliferation GO:0042102 9.71 IL6 IL4 IL1B CD4
13 maintenance of permeability of blood-brain barrier GO:0035633 9.67 PECAM1 IL6 ACTB
14 negative regulation of neurogenesis GO:0050768 9.65 TNF IL6 IL1B
15 regulation of establishment of endothelial barrier GO:1903140 9.63 TNF IL1B
16 positive regulation of glial cell proliferation GO:0060252 9.63 TNF IL6 IL1B
17 regulation of transmembrane transporter activity GO:0022898 9.61 INS ACTB
18 negative regulation of acute inflammatory response GO:0002674 9.61 INS IL4
19 negative regulation of lipid catabolic process GO:0050995 9.61 TNF INS IL1B
20 positive regulation of mononuclear cell migration GO:0071677 9.57 TNF IL4
21 positive regulation of fever generation GO:0031622 9.55 TNF IL1B
22 positive regulation of neuroinflammatory response GO:0150078 9.54 TNF IL6 IL1B
23 sequestering of triglyceride GO:0030730 9.52 TNF IL1B
24 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.51 TNF IL1B
25 negative regulation of lipid storage GO:0010888 9.33 TNF IL6 CRP
26 acute-phase response GO:0006953 9.26 INS IL6 FN1 CRP
27 vascular endothelial growth factor production GO:0010573 8.8 TNF IL6 IL1B

Molecular functions related to Actinomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.96 TNF POLR2B PECAM1 PAICS OSTF1 LGALS4
2 cytokine activity GO:0005125 9.46 TNF IL6 IL4 IL1B
3 identical protein binding GO:0042802 9.28 TNF PAICS INS GAPDH FN1 CRP

Sources for Actinomycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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