MCID: ACT055
MIFTS: 43

Actinomycosis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Actinomycosis

MalaCards integrated aliases for Actinomycosis:

Name: Actinomycosis 12 76 53 59 44 15 73
Keratoactinomycosis 53 73
Actinomycetoma 12 73
Canaliculitis 53 73
Boil 12 76
Madura Foot Due to Actinomadura 12
Anaerobic Actinomyces Infection 53
Actinomycotic Mycetoma of Foot 12
Actinomycotic Madura Foot 12
Actinomycotic Infection 12
Actinomycotic Mycetema 12
Actinomyces Israeli 53
Actinomycetes 53
Furuncle 73

Characteristics:

Orphanet epidemiological data:

59
actinomycosis
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 59  
Rare infectious diseases


Summaries for Actinomycosis

Disease Ontology : 12 A commensal bacterial infectious disease that results in infection, which is characterized by contiguous spread, suppurative and granulomatous inflammation, and formation of multiple abscesses and sinus tracts that may discharge sulfur granules, has material basis in Actinomyces israelii, has material basis in Actinomyces gerencseriae, has material basis in Actinomyces naeslundii, has material basis in Actinomyces odontolyticus, has material basis in Actinomyces viscosus, has material basis in Actinomyces meyeri, has material basis in Propionibacterium propionicum, which require a break in the integrity of the mucous membranes and the presence of devitalized tissue to invade deeper body structures.

MalaCards based summary : Actinomycosis, also known as keratoactinomycosis, is related to chronic canaliculitis and acute canaliculitis. An important gene associated with Actinomycosis is TMEM79 (Transmembrane Protein 79). The drugs Menthol and Thymol have been mentioned in the context of this disorder. Affiliated tissues include skin, colon and lung.

NIH Rare Diseases : 53 Actinomycosis is a chronic bacterial infection that commonly affects the face and neck. It is usually caused by an anaerobic bacteria called Actinomyces israelii. Actinomyces are normal inhabitants of the mouth, gastrointestinal tract, and female genital tract, and do not cause an infection unless there is a break in the skin or mucosa. The infection usually occurs in the face and neck, but can sometimes occur in the chest, abdomen, pelvis, or other areas of the body. The infection is not contagious.

Wikipedia : 76 Actinomycosis is a rare infectious bacterial disease caused by Actinomyces species. About 70% of... more...

Related Diseases for Actinomycosis

Diseases related to Actinomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 158)
# Related Disease Score Top Affiliating Genes
1 chronic canaliculitis 12.1
2 acute canaliculitis 12.0
3 hidradenitis suppurativa 11.3
4 carbuncle 11.2
5 olecranon bursitis 10.9
6 hordeolum 10.9
7 cutaneous leishmaniasis 10.8
8 biotin deficiency 10.8
9 diarrhea 10.8
10 cholera 10.8
11 perichondritis of auricle 10.8
12 prion disease 10.8
13 genetic prion diseases 10.8
14 hepatitis 10.3
15 esophagitis 10.1
16 lung cancer 10.1
17 mycobacterium chelonae 10.0
18 burns 10.0
19 osteomyelitis 10.0
20 tonsillitis 10.0
21 nocardiosis 10.0
22 pancreatitis 10.0
23 hydronephrosis 9.9
24 cervicitis 9.9
25 laryngitis 9.9
26 appendicitis 9.9
27 ovarian cancer 9.9
28 lymphogranuloma venereum 9.9
29 cryptosporidiosis 9.9
30 egg allergy 9.9
31 impetigo 9.9
32 bullous pemphigoid 9.9
33 pulmonary aspergilloma 9.8
34 nasopharyngitis 9.8
35 pneumonia 9.8
36 thyroiditis 9.8
37 breast cancer 9.8
38 plasmacytoma 9.8
39 aspergillosis 9.8
40 crohn's disease 9.8
41 sinusitis 9.8
42 thrombosis 9.8
43 epidural abscess 9.8
44 cardiac tamponade 9.8
45 adenocarcinoma 9.8
46 cerebritis 9.8
47 retroperitoneal fibrosis 9.8
48 langerhans cell histiocytosis 9.7
49 chronic kidney failure 9.7
50 salmonellosis 9.7

Graphical network of the top 20 diseases related to Actinomycosis:



Diseases related to Actinomycosis

Symptoms & Phenotypes for Actinomycosis

Drugs & Therapeutics for Actinomycosis

Drugs for Actinomycosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Menthol Approved Phase 4,Not Applicable 2216-51-5 16666
2
Thymol Approved Phase 4 89-83-8 6989
3
Ethanol Approved Phase 4 64-17-5 702
4
Methyl salicylate Approved, Vet_approved Phase 4 119-36-8 4133
5
Cetylpyridinium Approved Phase 4 7773-52-6
6
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
7
Ciclopirox Approved, Investigational Phase 4 29342-05-0 2749
8
Eucalyptol Approved, Nutraceutical Phase 4 470-82-6 2758
9 Fluorides Phase 4,Phase 3,Not Applicable
10 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Not Applicable,Early Phase 1
11 Anti-Infective Agents, Local Phase 4,Phase 3,Phase 1,Not Applicable
12 Pharmaceutical Solutions Phase 4,Not Applicable
13 Salicylates Phase 4
14 Antifungal Agents Phase 4
15
Triclosan Approved, Investigational Phase 3 3380-34-5 5564
16
BCG vaccine Investigational Phase 3
17
Tin Phase 3 7440-31-5
18 Tin Fluorides Phase 3
19 Hypolipidemic Agents Phase 3
20 Protective Agents Phase 3,Not Applicable,Early Phase 1
21 Lipid Regulating Agents Phase 3
22 Antimetabolites Phase 3
23 Cariostatic Agents Phase 3,Not Applicable
24 Alkylating Agents Phase 3
25 Adjuvants, Immunologic Phase 3
26 Mitomycins Phase 3
27 Nucleic Acid Synthesis Inhibitors Phase 3
28 Vaccines Phase 3
29 Anti-Bacterial Agents Phase 3
30 Antibiotics, Antitubercular Phase 3
31
Tofacitinib Approved, Investigational Phase 2 477600-75-2
32 Protein Kinase Inhibitors Phase 2
33
Chlorhexidine Approved, Vet_approved Phase 1,Not Applicable 55-56-1 9552079 2713
34 Chlorhexidine gluconate Phase 1,Not Applicable
35 Dermatologic Agents Phase 1
36 Disinfectants Phase 1
37 sodium fluoride Approved Not Applicable 7681-49-4
38 Antioxidants Early Phase 1
39 Antiparasitic Agents Early Phase 1
40 Listerine Not Applicable
41 Antiprotozoal Agents Early Phase 1
42 Antibodies
43 Immunoglobulins
44
Procyanidin Nutraceutical Early Phase 1 4852-22-6 147299
45 Anthocyanidin Nutraceutical Early Phase 1
46 Yellow Dock Nutraceutical Early Phase 1
47 Proanthocyanidin Nutraceutical Early Phase 1
48 arginine Nutraceutical

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Mouthwashes During Orthodontic Treatment Enrolling by invitation NCT03179735 Phase 4 Essential oils;Cetylpyridinium Chloride 0.7 mg/ml;Placebos
2 Safety Study of Ciclopirox Olamine Cream for Dermatomycoses in Children Terminated NCT01646580 Phase 4 ciclopirox
3 Investigate Oral Bacteria in Adult Population Completed NCT00762177 Phase 3 Fluoride;Fluoride, Triclosan;Stannous Fluoride
4 Adding Mitomycin C to Bacillus of Calmette-Guerin (BCG) as Adjuvant Intravesical Therapy for High-risk, Non-Muscle-invasive Bladder Cancer Recruiting NCT02948543 Phase 3 Mitomycin C (MMC)
5 A Open-Label Study Of CP-690,550 As Long-Term Therapy (48 Weeks) In Subjects With Crohn's Disease Completed NCT01470599 Phase 2 CP-690,550;CP-690,550
6 Chlorhexidine Gel Therapy for Cariogenic Oral Microflora Completed NCT01036412 Phase 1 1% Chlorhexidine Gluconate Gel
7 Oral Hygiene Care and Microflora in Elderly Residents Completed NCT02627469 Not Applicable
8 Assessment of the Impact of Probiotics on Biofilm Formation on Removable Acrylic Dentures Completed NCT02736994 Not Applicable PIP toothbrush cleaner® (Chrisal, Lommel, Belgium).;Corega Tabs Anti-bacteria®
9 Detection and Characteristic of Whipple Diseases in the Great Britany Completed NCT03350685
10 The Influence of Rumex Acetosa L on the Intraoral Colonization With Porphyromonas Gingivalis Completed NCT02039648 Early Phase 1
11 Interaction Between Immune Cells and Bacteria Associated With Periodontitis Recruiting NCT03225950
12 Oral Hygiene Intervention Pilot Study Active, not recruiting NCT02668809 Not Applicable
13 Assessment of Salivary Bacterial Level and Dental Caries Experience in a Group of Egyptian Children With Black Stained Teeth Not yet recruiting NCT03563469

Search NIH Clinical Center for Actinomycosis

Cochrane evidence based reviews: actinomycosis

Genetic Tests for Actinomycosis

Anatomical Context for Actinomycosis

MalaCards organs/tissues related to Actinomycosis:

41
Skin, Colon, Lung, Bone, Liver, Appendix, Tonsil

Publications for Actinomycosis

Articles related to Actinomycosis:

(show top 50) (show all 683)
# Title Authors Year
1
Actinomycosis ( 29489261 )
2018
2
Pulmonary actinomycosis mimicking a lung metastasis from esophageal cancer; a case report. ( 29486747 )
2018
3
Chronic Madura foot: mycetoma and/or <i>Actinomyces</i> spp or actinomycosis. ( 29789306 )
2018
4
Refractory actinomycosis of the humerus. ( 29348917 )
2018
5
Brain abscess caused by chronic invasive actinomycosis in the nasopharynx: A case report and literature review. ( 29668598 )
2018
6
A case of esophageal actinomycosis with a unique morphology presenting as a refractory ulcer. ( 29124648 )
2018
7
Actinomycosis of Distal Phalanx Twenty Years after Flap Reconstruction of Index Finger: A Case Report. ( 29725514 )
2018
8
Central Nervous System Actinomycosis-A Clinicoradiologic and Histopathologic Analysis. ( 29751182 )
2018
9
Rapid Bone Healing after Intentional Replantation of a Molar with Apical Actinomycosis. ( 29692850 )
2018
10
Wolf in Sheep's clothing: Intracranial actinomycosis masquerading as <i>en-plaque</i> meningioma. ( 29527397 )
2018
11
Nasal Cavity Actinomycosis Mimicking Rhinolith. ( 29461370 )
2018
12
Cervicofacial actinomycosis can obscure a malignancy: A case report. ( 29548682 )
2018
13
Pulmonary actinomycosis masquerading as lung cancer: keep it in mind. ( 29423982 )
2018
14
&amp;quot;Pulmonary Actinomycosis attributable to <i>Actinomyces meyeri</i> presenting as cardiac tamponade: a case report&amp;quot;. ( 29946465 )
2018
15
Actinomycosis, a lurking threat: a report of 11 cases and literature review. ( 29513846 )
2018
16
Hepatic actinomycosis with immunoglobulin G4-related liver disease: A case report. ( 29901644 )
2018
17
Intraabdominal actinomycosis resulting in a difficult to diagnose intraperitoneal mass: A case report. ( 29604528 )
2018
18
Retraction: Thoracic Vertebral Actinomycosis Secondary to a Pulmonary Origin. ( 29383289 )
2018
19
Intraabdominal and Pelvic actinomycosis in association with posterior reversible encephalopathy syndrome (PRES): A case report. ( 29758229 )
2018
20
Pulmonary Actinomycosis Mimicking Pulmonary Aspergilloma and a Brief Review of the Literature. ( 28202870 )
2017
21
Pulmonary Actinomycosis in a Patient with Chronic Eosinophilic Pneumonia treated with Omalizumab. ( 28720253 )
2017
22
Osteoma with actinomycosis in a nasal cavity: A case report. ( 29390536 )
2017
23
Nonhealing Wound at Wrist for 2 Years: Ultimately Proved to be Actinomycosis. ( 29263556 )
2017
24
Pulmonary actinomycosis coexisting with intestinal tuberculosis as a complication of adalimumab treatment for Crohn's disease. ( 29560655 )
2017
25
Actinomycosis is not Frequent in the Periapex But is a Persistent Lesion. ( 29211122 )
2017
26
Pulmonary Actinomycosis in a Patient with AIDS/HCV. ( 28764230 )
2017
27
Actinomycosis of the foot - A South African case. ( 28876622 )
2017
28
Pulmonary actinomycosis masquerading as aspergilloma. ( 28473686 )
2017
29
A case of relapsed lung abscess caused by Eubacterium brachy infection following an initial diagnosis of pulmonary actinomycosis. ( 28856090 )
2017
30
Pelvic actinomycosis fistulised to the skin, treated with doxycycline. ( 29446822 )
2017
31
Pericardial actinomycosis in a patient with oesophageal dysmotility and autoantibodies. ( 28783393 )
2017
32
A Complicated Thread: Abdominal Actinomycosis in a Young Woman with Crohn Disease. ( 28690491 )
2017
33
A rare case of subacute appendicitis, actinomycosis as the final pathology reports: A case report and literature review. ( 28531869 )
2017
34
Thoracic Actinomycosis With Infiltration of the Spine: An Oncological Pitfall. ( 29240031 )
2017
35
Periorbital actinomycosis masquerading as a cutaneous malignancy. ( 29181765 )
2017
36
Retroperitoneal Actinomycosis: A Rare Sequela of an Infected Obstructing Ureteral Stone. ( 28894842 )
2017
37
Omental actinomycosis imitating a foreign body infection. ( 28709171 )
2017
38
A bump in the groin: Cutaneous actinomycosis. ( 28932167 )
2017
39
Actinomycosis presenting as an anterior abdominal mass after laparoscopic cholecystectomy. ( 28536234 )
2017
40
Pulmonary actinomycosis masquerading as lung cancer: A case report. ( 28889138 )
2017
41
Pulmonary actinomycosis - the great imitator. ( 29936825 )
2017
42
Pancreatic Head Actinomycosis. ( 28755735 )
2017
43
Abdominal and pelvic actinomycosis due to longstanding intrauterine device: a slow and devastating infection. ( 28536687 )
2017
44
A rare coexistence of aspergillosis with actinomycosis. ( 28932040 )
2017
45
Primary pulmonary actinomycosis: a retrospective analysis of 145 cases in mainland China. ( 28633709 )
2017
46
Endobronchial actinomycosis associated with an inorganic foreign body. ( 28599808 )
2017
47
Actinomycosis Causing Recurrent Perianal Fistulae. ( 28670596 )
2017
48
Pelvic Actinomycosis. ( 28684963 )
2017
49
Cervical vertebral actinomycosis mimicking malignancy in a paediatric patient. ( 27033296 )
2016
50
Actinomycosis presenting as recurrent hepatic abscess. ( 27593605 )
2016

Variations for Actinomycosis

Expression for Actinomycosis

Search GEO for disease gene expression data for Actinomycosis.

Pathways for Actinomycosis

GO Terms for Actinomycosis

Sources for Actinomycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....