BOIL
MCID: ACT055
MIFTS: 51

Actinomycosis (BOIL)

Categories: Eye diseases, Gastrointestinal diseases, Infectious diseases, Rare diseases, Respiratory diseases
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Aliases & Classifications for Actinomycosis

MalaCards integrated aliases for Actinomycosis:

Name: Actinomycosis 11 19 58 75 43 14 16 71 31 33
Actinomycetoma 11 71 31 33
Canaliculitis 19 71 33
Actinomycotic Madura Foot 11 33
Actinomycotic Infection 11 33
Keratoactinomycosis 19 71
Furuncle 71 33
Actinomycotic Infection of Unspecified Site 33
Mycetoma Due to Filamentous Bacteria 33
Madura Foot Due to Actinomadura 11
Anaerobic Actinomyces Infection 19
Actinomycotic Mycetoma of Foot 11
Actinomycotic Mycetema 11
Actinomycotic Mycetoma 33
Actinomyces Infection 33
Actinomyces Israeli 19
Actinomycotic Node 33
Actinomycosis Nos 33
Actinomycetes 19
Boil 33

Characteristics:


Age Of Onset:

All ages 58

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 11 DOID:8478
ICD9CM 34 039.9
MeSH 43 D000196
NCIt 49 C34350
SNOMED-CT 68 50508009
ICD10 31 A42 A42.9 B47.1
ICD10 via Orphanet 32 A42.0 A42.1 A42.2 more
Orphanet 58 ORPHA457095
UMLS 71 C0001261 C0242301 C0423172 more

Summaries for Actinomycosis

Disease Ontology: 11 A commensal bacterial infectious disease that results in infection, which is characterized by contiguous spread, suppurative and granulomatous inflammation, and formation of multiple abscesses and sinus tracts that may discharge sulfur granules, has material basis in Actinomyces israelii, has material basis in Actinomyces gerencseriae, has material basis in Actinomyces naeslundii, has material basis in Actinomyces odontolyticus, has material basis in Actinomyces viscosus, has material basis in Actinomyces meyeri, has material basis in Propionibacterium propionicum, which require a break in the integrity of the mucous membranes and the presence of devitalized tissue to invade deeper body structures.

MalaCards based summary: Actinomycosis, also known as actinomycetoma, is related to carbuncle and olecranon bursitis. An important gene associated with Actinomycosis is CRP (C-Reactive Protein), and among its related pathways/superpathways are PPARA activates gene expression and Adipogenesis. The drugs Racepinephrine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and lung, and related phenotypes are muscle and cellular

GARD: 19 Actinomycosis is a bacterial infection that occurs most often in the face and neck. Symptoms of Actinomycosis include a neck mass, jaw or face pain, and formation of pockets of pus (abscess). When Actinomycosis occurs in other parts of the body, symptoms can include cough, chest or stomach pain, fever, and weight loss. It is usually caused by bacteria called Actinomyces israelii. These bacteria are found normally in the mouth, gastrointestinal tract, and female genital tract, and do not cause an infection unless there is a break in the skin or mucosa. The infection is not contagious. Actinomycosis is diagnosed based on the history and clinical exam, and through specific laboratory tests.

Orphanet: 58 A rare bacterial infectious disease characterized by a chronic granulomatous infection by Actinomyces species which are commensals in the human gastrointestinal and urogenital tract and oropharynx. Corresponding to the affected site, the disease presents as cervicofacial, respiratory tract, genitourinary tract, digestive tract, central nervous system, or cutaneous actinomycosis and leads to the formation of abscesses and fistulae in the respective region.

Wikipedia: 75 Actinomycosis is a rare infectious bacterial disease caused by Actinomyces species. The name refers to... more...

Related Diseases for Actinomycosis

Diseases related to Actinomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1099)
# Related Disease Score Top Affiliating Genes
1 carbuncle 32.2 TNF ALB
2 olecranon bursitis 32.0 HSPD1 CRP
3 ventilation pneumonitis 31.9 CRP CD4
4 pleural empyema 30.8 CRP CD4 ALB
5 osteomyelitis 30.7 TNF IL10 CRP
6 nocardiosis 30.6 TNF HSPD1 CRP CD4
7 intracranial abscess 30.6 CRP CD4
8 diverticulitis 30.4 TNF CRP ALB
9 orbital cellulitis 30.4 CRP CD4
10 breast abscess 30.4 CRP CD4
11 mastoiditis 30.4 CRP CD4
12 blastomycosis 30.3 TNF CRP CD4
13 appendicitis 30.3 TNF IL10 CRP ALB
14 epidural abscess 30.3 CRP CD4 ALB
15 cavernous sinus thrombosis 30.2 CRP CD4
16 glanders 30.2 HSPD1 CD4
17 pyomyositis 30.2 CRP CD4
18 lung abscess 30.2 TNF CRP CD4 ALB
19 chronic conjunctivitis 30.2 TNF IL10 CD4
20 urinary tract obstruction 30.2 TNF CRP ALB
21 alcohol use disorder 30.1 TNF CRP CD4 ALB
22 purulent endophthalmitis 30.1 CRP CD4
23 cutaneous leishmaniasis 30.1 TNF IL10 CD4
24 mediastinitis 30.1 CRP CD4 ALB
25 bronchiectasis 30.1 TNF CRP ALB
26 anal fistula 30.0 TNF CRP ALB
27 pericardial effusion 30.0 TNF CRP CD4 ALB
28 colonic benign neoplasm 30.0 TNF PPARG IL10 CD4
29 intestinal obstruction 30.0 TNF CRP ALB
30 splenic abscess 30.0 CRP CD4 ALB
31 toxic shock syndrome 30.0 TNF IL10 CRP
32 ileus 29.9 TNF IL10 CRP
33 peritonitis 29.9 TNF IL10 CRP ALB
34 rocky mountain spotted fever 29.9 HSPD1 CRP CD4
35 optic papillitis 29.9 TNF CRP CD4
36 hemorrhoid 29.9 TNF CRP ALB
37 keratitis, hereditary 29.9 TNF IL10 CD4
38 pulmonary tuberculosis 29.9 TNF IL10 CRP ALB
39 ascaris lumbricoides infection 29.8 IL10 CD4 ALB
40 dry eye syndrome 29.8 TNF IL10 CD4
41 klebsiella pneumonia 29.8 CRP ALB
42 giardiasis 29.8 IL10 CD4 ALB
43 cellulitis 29.8 TNF CRP CD4 ALB
44 legionnaire disease 29.8 TNF CRP CD4
45 cauda equina syndrome 29.8 TNF CRP
46 mucormycosis 29.8 TNF IL10 CRP CD4
47 peptic ulcer perforation 29.8 CRP ALB
48 bartonellosis 29.8 HSPD1 CRP CD4
49 dermatophytosis 29.8 TNF POLR2B CD4
50 pneumonia 29.8 TNF IL10 CRP ALB

Graphical network of the top 20 diseases related to Actinomycosis:



Diseases related to Actinomycosis

Symptoms & Phenotypes for Actinomycosis

MGI Mouse Phenotypes related to Actinomycosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.97 ALB CEBPA FABP4 HSPD1 IL10 PPARG
2 cellular MP:0005384 9.96 ALB CD4 CEBPA COIL FABP4 HSPD1
3 liver/biliary system MP:0005370 9.92 ALB CEBPA DISP3 FABP4 IL10 PPARG
4 cardiovascular system MP:0005385 9.85 ALB CEBPA CRP DISP3 FABP4 HSPD1
5 immune system MP:0005387 9.65 ALB CD4 CEBPA CNTN5 CRP DISP3
6 mortality/aging MP:0010768 9.4 ALB CD4 CEBPA COIL DISP3 FABP4

Drugs & Therapeutics for Actinomycosis

Drugs for Actinomycosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Racepinephrine Approved, Vet_approved Phase 4 51-43-4, 329-65-7 838 5816
2
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
3 Epinephryl borate Phase 4
4 Bronchodilator Agents Phase 4
5 Neurotransmitter Agents Phase 4
6 Adrenergic beta-Agonists Phase 4
7 Adrenergic alpha-Agonists Phase 4
8 Adrenergic Agonists Phase 4
9 Adrenergic Agents Phase 4
10 Anti-Asthmatic Agents Phase 4
11 Anti-Arrhythmia Agents Phase 4
12 Sodium Channel Blockers Phase 4
13 Vasoconstrictor Agents Phase 4
14 Anesthetics, Local Phase 4
15 Respiratory System Agents Phase 4
16 Anesthetics Phase 4
17 Mydriatics Phase 4
18 Sympathomimetics Phase 4
19 Diuretics, Potassium Sparing Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Clinical Trial of Wound Packing Following Incision and Drainage of Superficial Skin Abscesses in the Pediatric Emergency Department Completed NCT00746109 Phase 4
2 Bacteriostatic Saline as a Local Anesthetic in Minor Eyelid Procedures Not yet recruiting NCT05294640 Phase 4 0.9% Bacteriostatic Local Anesthetic Injection;1% Lidocaine with 1:100,000 epinephrine Local Anesthetic Injection

Search NIH Clinical Center for Actinomycosis

Cochrane evidence based reviews: actinomycosis

Genetic Tests for Actinomycosis

Anatomical Context for Actinomycosis

Organs/tissues related to Actinomycosis:

MalaCards : Skin, Eye, Lung, Colon, Liver, Tongue, Appendix

Publications for Actinomycosis

Articles related to Actinomycosis:

(show top 50) (show all 11244)
# Title Authors PMID Year
1
Imaging of Uncommon Bacterial, Rickettsia, Spirochete, and Fungal Infections. 62
36404049 2023
2
Spatial and temporal dynamics of microbial community composition and factors influencing the surface water and sediments of urban rivers. 62
36182129 2023
3
Genome scale metabolic model combined with single molecule real-time sequencing to analyze Actinomycete chromosomal heterogeneity. 62
36220451 2023
4
Characterization of non-taste & odor produced aerobic denitrification actinomycetes strains Streptomyces spp. isolated from reservoir ecosystem: Denitrification performance and carbon source metabolism. 62
36347481 2023
5
Pulmonary arterial pseudoaneurysm as an unusual complication of pulmonary actinomycosis: Two case reports. 62
36340225 2023
6
Streptomyces genus as a source of probiotics and its potential for its use in health. 62
36335804 2023
7
Cloning and Expression of Metagenomic DNA in Streptomyces lividans and Its Subsequent Fermentation for Optimized Production. 62
36306090 2023
8
Mechanisms underlying the succession of plant rhizosphere microbial community structure and function in an alpine open-pit coal mining disturbance zone. 62
36308787 2023
9
Application of Sophora alopecuroides organic fertilizer changes the rhizosphere microbial community structure of melon plants and increases the fruit sugar content. 62
35837792 2023
10
m4C DNA methylation regulates biosynthesis of daptomycin in Streptomyces roseosporus L30. 62
35801092 2022
11
Screening for microbial potentiators of neutral lipid degradation in CHO-K1 cells. 62
36450503 2022
12
Potential of indigenous ligno-cellulolytic microbial consortium to accelerate degradation of heterogenous crop residues. 62
35834084 2022
13
[A PhD completed. Predictability and long-term effects of MAD treatment of obstructive sleep apnea]. 62
36472309 2022
14
A rare diagnosis of pulmonary actinomycosis by bronchoalveolar lavage cytology. 62
36458469 2022
15
Rhodococcus: A promising genus of actinomycetes for the bioremediation of organic and inorganic contaminants. 62
36116255 2022
16
Cytotoxic potential of Nephthea sp.-derived actinomycetes supported by metabolomics analysis. 62
35175884 2022
17
Construction of actinomycetes complex flora in degrading corn straw and an evaluation of their degradative effects. 62
36315299 2022
18
Diversity and Biotechnological Potential of Marine Actinomycetes from India. 62
35601673 2022
19
Epidemiology and in vitro antimicrobial susceptibility of aerobic Actinomycetales in a clinical setting. 62
36464473 2022
20
A prospective study comparing mini-invasive and conventional canaliculotomy of punctum-sparing canaliculotomy for primary canaliculitis treatment. 62
36473974 2022
21
Genotype-by-environment interaction and stability of root mealiness and other organoleptic properties of boiled cassava roots. 62
36463268 2022
22
Probing the electronic relaxation pathways and photostability of the synthetic nucleobase Z via laser interfaced mass spectrometry. 62
36354978 2022
23
A novel, magnetic bead-based extraction method for the isolation of antimicrobial resistance genes with a case study in river water in Malawi. 62
35946113 2022
24
Long-Term Outcomes of Canaliculotomy with Silicone Tube Intubation in the Management of Canaliculitis. 62
36431305 2022
25
Staphylococcus aureus causing primary foot botryomycosis mimicking actinomycetoma: a case report from Sudan. 62
36241164 2022
26
Metagenomics of infective canaliculitis: The Lacriome paper 3. 62
35354326 2022
27
Microbiological status of natural and anthropogenic soils of the Taganrog Bay coast at different levels of combined pollution with heavy metals and PAHs. 62
36436180 2022
28
A BioBricks Metabolic Engineering Platform for the Biosynthesis of Anthracyclinones in Streptomyces coelicolor. 62
36378506 2022
29
Nitric Oxide Signaling for Aerial Mycelium Formation in Streptomyces coelicolor A3(2) M145. 62
36354316 2022
30
Isolation and Characterization of a Novel Actinomycete Isolated from Marine Sediments and Its Antibacterial Activity against Fish Pathogens. 62
36358200 2022
31
Metabolomic Profiling, In Vitro Antimalarial Investigation and In Silico Modeling of the Marine Actinobacterium Strain Rhodococcus sp. UR111 Associated with the Soft Coral Nephthea sp. 62
36421275 2022
32
Bioinsecticidal activity of actinomycete secondary metabolites against the acetylcholinesterase of the legume's insect pest Acyrthosiphon pisum: a computational study. 62
36417041 2022
33
1-(6-Methylsalicyloyl)glycerol from stony coral-derived Micromonospora sp. 62
36446953 2022
34
Volatile Compounds in Actinomycete Communities: A New Tool for Biosynthetic Gene Cluster Activation, Cooperative Growth Promotion, and Drug Discovery. 62
36359906 2022
35
Mechanism of 17β-estradiol degradation by Rhodococcus equi via the 4,5-seco pathway and its key genes. 62
36037852 2022
36
Screening, isolation and mechanism of a nematicidal extract from actinomycetes against the pine wood nematode Bursaphelenchus xylophilus. 62
36425437 2022
37
Systematic Review of Actinomycetes in the Baijiu Fermentation Microbiome. 62
36429142 2022
38
Biosynthesis of silver nanoparticles using actinomycetes, phytotoxicity on rice seeds, and potential application in the biocontrol of phytopathogens. 62
36336636 2022
39
Antibiofilm properties of bioactive compounds from Actinomycetes against foodborne and fish pathogens. 62
36329158 2022
40
Clinical features and treatment outcomes of pulmonary actinomycosis. 62
36394726 2022
41
A Case of Actinomycosis in the Rosenmüller's Fossa. 62
33236645 2022
42
Colloid cyst with hyphal-like structures: A rarity that mimics actinomycosis of the third ventricle. 62
36366963 2022
43
Actinomycosis of the nasal cavity. 62
34112606 2022
44
[Clinical presentation and short-term treatment of pulmonary actinomycosis]. 62
36382979 2022
45
Sanitary sewage overflows, boil water advisories, and emergency room and urgent care visits for gastrointestinal illness: a case-crossover study in South Carolina, USA, 2013-2017. 62
36376586 2022
46
Actinomycosis of the Middle Ear in Children: Case Report and Literature Review. 62
36102698 2022
47
Comparative Study of Antimicrobial Activity of Silver, Gold, and Silver/Gold Bimetallic Nanoparticles Synthesized by Green Approach. 62
36431998 2022
48
A case report of pulmonary nocardiosis during pembrolizumab: the emerging challenge of the infections on immunotherapy. 62
36420679 2022
49
Actinomycosis and osteonecrosis of the jaw: Every why hides a why. 62
35640875 2022
50
Laryngeal and pharyngeal actinomycosis: a systematic review and report of 3 cases. 62
36029619 2022

Variations for Actinomycosis

Expression for Actinomycosis

Search GEO for disease gene expression data for Actinomycosis.

Pathways for Actinomycosis

GO Terms for Actinomycosis

Biological processes related to Actinomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA-templated transcription GO:0045893 10.13 ANKRD49 CD4 CEBPA IL10 PPARG RUNX2
2 positive regulation of miRNA transcription GO:1902895 9.88 TNF PPARG IL10
3 negative regulation of cytokine production involved in immune response GO:0002719 9.67 TNF IL10
4 positive regulation of macrophage activation GO:0043032 9.63 IL10 HSPD1 CEBPA
5 response to organic substance GO:0010033 9.61 TNF PPARG IL10
6 chronic inflammatory response to antigenic stimulus GO:0002439 9.56 TNF IL10
7 white fat cell differentiation GO:0050872 9.43 PPARG FABP4 CEBPA
8 negative regulation of lipid storage GO:0010888 9.1 TNF PPARG CRP

Sources for Actinomycosis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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