MCID: ACT055
MIFTS: 46

Actinomycosis

Categories: Infectious diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Actinomycosis

MalaCards integrated aliases for Actinomycosis:

Name: Actinomycosis 12 77 54 60 45 15 17 74
Boil 12 77 15
Keratoactinomycosis 54 74
Actinomycetoma 12 74
Canaliculitis 54 74
Madura Foot Due to Actinomadura 12
Anaerobic Actinomyces Infection 54
Actinomycotic Mycetoma of Foot 12
Actinomycotic Madura Foot 12
Actinomycotic Infection 12
Actinomycotic Mycetema 12
Actinomyces Israeli 54
Actinomycetes 54
Furuncle 74

Characteristics:

Orphanet epidemiological data:

60
actinomycosis
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:8478
ICD9CM 36 039 039.9
MeSH 45 D000196
NCIt 51 C34350
SNOMED-CT 69 11817007 50508009
ICD10 34 A42 A42.9 B47.1
ICD10 via Orphanet 35 A42.0 A42.1 A42.2 more
Orphanet 60 ORPHA457095

Summaries for Actinomycosis

Disease Ontology : 12 A commensal bacterial infectious disease that results in infection, which is characterized by contiguous spread, suppurative and granulomatous inflammation, and formation of multiple abscesses and sinus tracts that may discharge sulfur granules, has material basis in Actinomyces israelii, has material basis in Actinomyces gerencseriae, has material basis in Actinomyces naeslundii, has material basis in Actinomyces odontolyticus, has material basis in Actinomyces viscosus, has material basis in Actinomyces meyeri, has material basis in Propionibacterium propionicum, which require a break in the integrity of the mucous membranes and the presence of devitalized tissue to invade deeper body structures.

MalaCards based summary : Actinomycosis, also known as boil, is related to brucellosis and gastroenteritis. An important gene associated with Actinomycosis is CTTNBP2 (Cortactin Binding Protein 2), and among its related pathways/superpathways are Visual Cycle in Retinal Rods and Development_Thrombopoetin signaling via JAK-STAT pathway. The drugs Menthol and Thymol have been mentioned in the context of this disorder. Affiliated tissues include lung, colon and skin.

NIH Rare Diseases : 54 Actinomycosis is a chronic bacterial infection that commonly affects the face and neck. It is usually caused by an anaerobic bacteria called Actinomyces israelii. Actinomyces are normal inhabitants of the mouth, gastrointestinal tract, and female genital tract, and do not cause an infection unless there is a break in the skin or mucosa. The infection usually occurs in the face and neck, but can sometimes occur in the chest, abdomen, pelvis, or other areas of the body. The infection is not contagious.

Wikipedia : 77 Actinomycosis is a rare infectious bacterial disease caused by Actinomyces species. About 70% of... more...

Related Diseases for Actinomycosis

Diseases related to Actinomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 298)
# Related Disease Score Top Affiliating Genes
1 brucellosis 29.9 CRP IL4
2 gastroenteritis 29.7 CRP IL4
3 mediastinitis 29.6 CRP RERE
4 periodontitis 29.6 CRP IL4
5 bone inflammation disease 29.4 CRP IL4
6 acute canaliculitis 12.4
7 chronic canaliculitis 12.3
8 cutaneous leishmaniasis 11.6
9 hidradenitis suppurativa 11.5
10 farmer's lung 11.4
11 bagassosis 11.4
12 diarrhea 11.4
13 cholera 11.4
14 carbuncle 11.4
15 olecranon bursitis 11.1
16 hordeolum 11.1
17 ventilation pneumonitis 11.1
18 mushroom workers' lung 11.1
19 biotin deficiency 11.0
20 perichondritis of auricle 11.0
21 agammaglobulinemia 11.0
22 prion disease 11.0
23 primary agammaglobulinemia 11.0
24 osteomyelitis 10.3
25 nocardiosis 10.3
26 lung cancer 10.2
27 appendicitis 10.2
28 ovarian cancer 10.2
29 pleural empyema 10.2
30 mycobacterium chelonae 10.1
31 lymphoma 10.1
32 hydronephrosis 10.1
33 aortitis 10.1 CRP RERE
34 crohn's disease 10.1
35 cardiac tamponade 10.1
36 egg allergy 10.1
37 leishmaniasis 10.1
38 primary orthostatic tremor 10.1
39 aspergillosis 10.0
40 thrombosis 10.0
41 tolosa-hunt syndrome 10.0
42 bronchus cancer 10.0
43 blood group, colton system 10.0
44 papilloma 10.0
45 carney complex, type 1 10.0
46 pigmentary disorder, reticulate, with systemic manifestations, x-linked 10.0
47 caronte 10.0
48 chromoblastomycosis 10.0
49 ankylosis 10.0
50 alexithymia 10.0 CRP IL4

Graphical network of the top 20 diseases related to Actinomycosis:



Diseases related to Actinomycosis

Symptoms & Phenotypes for Actinomycosis

Drugs & Therapeutics for Actinomycosis

Drugs for Actinomycosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Menthol Approved Phase 4 2216-51-5 16666
2
Thymol Approved Phase 4 89-83-8 6989
3
Methyl salicylate Approved, Vet_approved Phase 4 119-36-8 4133
4
Ethanol Approved Phase 4 64-17-5 702
5
Cetylpyridinium Approved Phase 4 7773-52-6
6
Ciclopirox Approved, Investigational Phase 4 29342-05-0 2749
7
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
8 Pharmaceutical Solutions Phase 4,Not Applicable
9 Fluorides Phase 4,Phase 3,Not Applicable
10 Anti-Infective Agents, Local Phase 4,Phase 3,Phase 1,Not Applicable
11 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Not Applicable,Early Phase 1
12 Salicylates Phase 4
13 Antifungal Agents Phase 4
14
Eucalyptol Experimental, Nutraceutical Phase 4 470-82-6 2758
15
Triclosan Approved, Investigational Phase 3 3380-34-5 5564
16
BCG vaccine Investigational Phase 3
17 Hypolipidemic Agents Phase 3
18 Cariostatic Agents Phase 3,Not Applicable
19 Lipid Regulating Agents Phase 3
20 Antimetabolites Phase 3
21 Tin Fluorides Phase 3
22
Tin Phase 3 7440-31-5
23 Protective Agents Phase 3,Not Applicable,Early Phase 1
24 Immunologic Factors Phase 3
25 Antibiotics, Antitubercular Phase 3
26 Alkylating Agents Phase 3
27 Vaccines Phase 3
28 Anti-Bacterial Agents Phase 3
29 Mitomycins Phase 3
30 Nucleic Acid Synthesis Inhibitors Phase 3
31 Adjuvants, Immunologic Phase 3
32
Tofacitinib Approved, Investigational Phase 2 477600-75-2
33 Protein Kinase Inhibitors Phase 2
34
Chlorhexidine Approved, Vet_approved Phase 1,Not Applicable 55-56-1 2713 9552079
35 Dermatologic Agents Phase 1
36 Disinfectants Phase 1
37 Chlorhexidine gluconate Phase 1,Not Applicable
38 sodium fluoride Approved Not Applicable 7681-49-4
39 Listerine Not Applicable
40 Yellow Dock Early Phase 1
41 Proanthocyanidin Early Phase 1
42 Antioxidants Early Phase 1
43 Antiprotozoal Agents Early Phase 1
44
Procyanidin Early Phase 1 4852-22-6 147299
45 Anthocyanidin Early Phase 1
46 Antiparasitic Agents Early Phase 1
47 arginine
48 Antibodies
49 Immunoglobulins

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Mouthwashes During Orthodontic Treatment Enrolling by invitation NCT03179735 Phase 4 Essential oils;Cetylpyridinium Chloride 0.7 mg/ml;Placebos
2 Safety Study of Ciclopirox Olamine Cream for Dermatomycoses in Children Terminated NCT01646580 Phase 4 ciclopirox
3 Investigate Oral Bacteria in Adult Population Completed NCT00762177 Phase 3 Fluoride;Fluoride, Triclosan;Stannous Fluoride
4 Adding Mitomycin C to Bacillus of Calmette-Guerin (BCG) as Adjuvant Intravesical Therapy for High-risk, Non-Muscle-invasive Bladder Cancer Recruiting NCT02948543 Phase 3 Mitomycin C (MMC)
5 A Open-Label Study Of CP-690,550 As Long-Term Therapy (48 Weeks) In Subjects With Crohn's Disease Completed NCT01470599 Phase 2 CP-690,550;CP-690,550
6 Chlorhexidine Gel Therapy for Cariogenic Oral Microflora Completed NCT01036412 Phase 1 1% Chlorhexidine Gluconate Gel
7 Oral Hygiene Care and Microflora in Elderly Residents Completed NCT02627469 Not Applicable
8 Oral Hygiene Intervention Pilot Study Completed NCT02668809 Not Applicable
9 Assessment of the Impact of Probiotics on Biofilm Formation on Removable Acrylic Dentures Completed NCT02736994 Not Applicable PIP toothbrush cleaner® (Chrisal, Lommel, Belgium).;Corega Tabs Anti-bacteria®
10 Detection and Characteristic of Whipple Diseases in the Great Britany Completed NCT03350685
11 The Influence of Rumex Acetosa L on the Intraoral Colonization With Porphyromonas Gingivalis Completed NCT02039648 Early Phase 1
12 Interaction Between Immune Cells and Bacteria Associated With Periodontitis Active, not recruiting NCT03225950
13 Assessment of Salivary Bacterial Level and Dental Caries Experience in a Group of Egyptian Children With Black Stained Teeth Not yet recruiting NCT03563469

Search NIH Clinical Center for Actinomycosis

Cochrane evidence based reviews: actinomycosis

Genetic Tests for Actinomycosis

Anatomical Context for Actinomycosis

MalaCards organs/tissues related to Actinomycosis:

42
Lung, Colon, Skin, Liver, Bone, Breast, Tongue

Publications for Actinomycosis

Articles related to Actinomycosis:

(show top 50) (show all 2173)
# Title Authors Year
1
Acute abdomen caused by actinomycosis. ( 29784476 )
2019
2
Actinomycosis-induced adnexal and uterine masses mimicking malignancy on FDG PET/CT. ( 30096319 )
2019
3
Actinomycosis-induced Trismus with Orbital Involvement. ( 30101938 )
2019
4
Pancreatic Actinomycosis. ( 30187330 )
2019
5
A case of thoracic actinomycosis presenting as sudden paraplegia. ( 30309660 )
2019
6
Atypical Form of Cervicofacial Actinomycosis Involving the Skull Base and Temporal Bone. ( 30371104 )
2019
7
Intracranial Actinomycosis Manifesting as a Parenchymal Mass Lesion: A Case Report and Review of Literature. ( 30391617 )
2019
8
Actinomycosis of tongue: Rare presentation mimicking malignancy with literature review and imaging features. ( 30425772 )
2019
9
Splendore-Hoeppli phenomenon in a fine needle aspirate of cervicofacial actinomycosis. ( 30488615 )
2019
10
Pulmonary actinomycosis in a free-living black-tufted marmoset (Callithrix penicillata). ( 30635747 )
2019
11
Actinomycosis of the omentum with invasion of the abdominal wall, small bowel and transverse colon mimicking malignancy. ( 30696650 )
2019
12
A case report of esophageal actinomycosis in an immunocompetent patient and review of the literature. ( 30785207 )
2019
13
Palatal actinomycosis osteomyelitis-Complication of impacted tooth in a diabetic. ( 30820977 )
2019
14
Deep ulcerative esophagitis: A rare presentation of gastrointestinal actinomycosis. ( 30824406 )
2019
15
Primary urachal actinomycosis: A case report. ( 30905551 )
2019
16
A case series of actinomycosis from a single tertiary care center in Saudi Arabia. ( 30937285 )
2019
17
Laryngeal Actinomycosis: A Rare Cause of Dysphonia. ( 30943809 )
2019
18
Actinomycosis of the breast and lungs. ( 30956585 )
2019
19
Rhinocerebral mucormycosis associated with actinomycosis in a diabetic patient: A rare presentation. ( 30967740 )
2019
20
Actinomyces naeslundii causing pulmonary endobronchial Actinomycosis - A case report. ( 30971569 )
2019
21
A case of recurrent hemoptysis caused by pulmonary actinomycosis diagnosed using transbronchial lung biopsy after bronchial artery embolism and a brief review of the literature. ( 31019958 )
2019
22
Mimicking oesophageal cancer: oesophageal actinomycosis. ( 31034399 )
2019
23
Ruptured Appendicitis and a Palpable Mass: Delayed Presentation of Appendiceal Actinomycosis. ( 31043216 )
2019
24
Ruptured Appendicitis and a Palpable Mass: Delayed Presentation of Appendiceal Actinomycosis. ( 31053193 )
2019
25
Abdominal Actinomycosis Mimicking Colon Cancer. ( 31060658 )
2019
26
Actinomycosis of the scalp or tuberculosis? A clinical conundrum! ( 31110072 )
2019
27
Histopathological evaluation of a rare fulminant case of contemporaneous mucormycosis, aspergillosis and actinomycosis. ( 31110432 )
2019
28
Genomic focus brings tea research to the boil. ( 30728517 )
2019
29
Does CMS' Meaningful Measures initiative boil down to cost-benefit analysis? ( 30763035 )
2019
30
Pulmonary actinomycosis masquerading as lung cancer: keep it in mind. ( 29423982 )
2018
31
Nasal Cavity Actinomycosis Mimicking Rhinolith. ( 29461370 )
2018
32
Pulmonary actinomycosis mimicking a lung metastasis from esophageal cancer; a case report. ( 29486747 )
2018
33
Actinomycosis, a lurking threat: a report of 11 cases and literature review. ( 29513846 )
2018
34
Wolf in Sheep's clothing: Intracranial actinomycosis masquerading as en-plaque meningioma. ( 29527397 )
2018
35
Cervicofacial actinomycosis can obscure a malignancy: A case report. ( 29548682 )
2018
36
Intraabdominal actinomycosis resulting in a difficult to diagnose intraperitoneal mass: A case report. ( 29604528 )
2018
37
Brain abscess caused by chronic invasive actinomycosis in the nasopharynx: A case report and literature review. ( 29668598 )
2018
38
Rapid Bone Healing after Intentional Replantation of a Molar with Apical Actinomycosis. ( 29692850 )
2018
39
Actinomycosis of Distal Phalanx Twenty Years after Flap Reconstruction of Index Finger: A Case Report. ( 29725514 )
2018
40
Central Nervous System Actinomycosis-A Clinicoradiologic and Histopathologic Analysis. ( 29751182 )
2018
41
Intraabdominal and Pelvic actinomycosis in association with posterior reversible encephalopathy syndrome (PRES): A case report. ( 29758229 )
2018
42
Chronic Madura foot: mycetoma and/or Actinomyces spp or actinomycosis. ( 29789306 )
2018
43
Hepatic actinomycosis with immunoglobulin G4-related liver disease: A case report. ( 29901644 )
2018
44
"Pulmonary Actinomycosis attributable to Actinomyces meyeri presenting as cardiac tamponade: a case report". ( 29946465 )
2018
45
Actinomyces meyeri: A Rare Cause of Postsurgical Pelvic Actinomycosis. ( 30034893 )
2018
46
Rare Case of Male Pelvic Actinomycosis. ( 30039030 )
2018
47
Actinomycosis: An infrequent disease in renal transplant recipients? ( 30055044 )
2018
48
Severe abdominopelvic actinomycosis with colon perforation and hepatic involvement mimicking advanced sigmoid colon cancer with hepatic metastasis: a case study. ( 30068330 )
2018
49
Rare Abdominopelvic Actinomycosis Causing an Intestinal Band Obstruction and Mimicking an Ovarian Malignancy. ( 30079287 )
2018
50
Comment on "Intra-abdominal actinomycosis resulting in a difficult-to-diagnose intraperitoneal mass: A case study report''. ( 30087029 )
2018

Variations for Actinomycosis

Expression for Actinomycosis

Search GEO for disease gene expression data for Actinomycosis.

Pathways for Actinomycosis

Pathways related to Actinomycosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.6 CRP RDH11
2 10.32 CRP RDH11

GO Terms for Actinomycosis

Sources for Actinomycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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