BOIL
MCID: ACT055
MIFTS: 47

Actinomycosis (BOIL)

Categories: Gastrointestinal diseases, Infectious diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Actinomycosis

MalaCards integrated aliases for Actinomycosis:

Name: Actinomycosis 12 74 52 58 43 15 17 71 32
Actinomycetoma 12 71 32
Keratoactinomycosis 52 71
Canaliculitis 52 71
Boil 12 74
Madura Foot Due to Actinomadura 12
Anaerobic Actinomyces Infection 52
Actinomycotic Mycetoma of Foot 12
Actinomycotic Madura Foot 12
Actinomycotic Infection 12
Actinomycotic Mycetema 12
Actinomyces Israeli 52
Actinomycetes 52
Furuncle 71

Characteristics:

Orphanet epidemiological data:

58
actinomycosis
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:8478
ICD9CM 34 039.9
MeSH 43 D000196
NCIt 49 C34350
SNOMED-CT 67 11817007
ICD10 32 A42 A42.9 B47.1
ICD10 via Orphanet 33 A42.0 A42.1 A42.2 more
Orphanet 58 ORPHA457095
UMLS 71 C0001261 C0242301 C0423172 more

Summaries for Actinomycosis

NIH Rare Diseases : 52 Actinomycosis is a bacterial infection that occurs most often in the face and neck. Symptoms of actinomycosis include a neck mass, jaw or face pain, and formation of pockets of pus (abscess). When actinomycosis occurs in other parts of the body, symptoms can include cough, chest or stomach pain, fever, and weight loss. It is usually caused by bacteria called Actinomyces israelii . These bacteria are found normally in the mouth, gastrointestinal tract, and female genital tract, and do not cause an infection unless there is a break in the skin or mucosa . The infection is not contagious. Actinomycosis is diagnosed based on the history and clinical exam, and through specific laboratory tests. It is treated with antibiotics .

MalaCards based summary : Actinomycosis, also known as actinomycetoma, is related to epidural abscess and splenic abscess. An important gene associated with Actinomycosis is ADD2 (Adducin 2), and among its related pathways/superpathways is Miscellaneous transport and binding events. The drugs Simethicone and Budesonide have been mentioned in the context of this disorder. Affiliated tissues include lung, colon and skin.

Disease Ontology : 12 A commensal bacterial infectious disease that results in infection, which is characterized by contiguous spread, suppurative and granulomatous inflammation, and formation of multiple abscesses and sinus tracts that may discharge sulfur granules, has material basis in Actinomyces israelii, has material basis in Actinomyces gerencseriae, has material basis in Actinomyces naeslundii, has material basis in Actinomyces odontolyticus, has material basis in Actinomyces viscosus, has material basis in Actinomyces meyeri, has material basis in Propionibacterium propionicum, which require a break in the integrity of the mucous membranes and the presence of devitalized tissue to invade deeper body structures.

Wikipedia : 74 Actinomycosis is a rare infectious bacterial disease caused by Actinomyces species. About 70% of... more...

Related Diseases for Actinomycosis

Diseases related to Actinomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 768)
# Related Disease Score Top Affiliating Genes
1 epidural abscess 30.9 CRP ALB
2 splenic abscess 30.6 CRP ALB
3 subdural empyema 30.6 CRP ASPRV1
4 neurofibromatosis, type ii 30.6 PRDM10 GAPDH ALB
5 sleeping sickness 30.5 PRDM10 H2AC18 GAPDH
6 endophthalmitis 30.5 CRP ASPRV1 ALB
7 mediastinitis 30.4 CRP ALB
8 klebsiella pneumonia 30.4 CRP ALB
9 peptic ulcer perforation 30.3 CRP ALB
10 corneal disease 30.3 TNFRSF10C PRDM10 H2AC18 ALB
11 endocarditis 30.3 GAPDH CRP ALB
12 fungal infectious disease 30.2 H2AC18 CRP ALB
13 exanthem 30.2 H2AC18 CRP ALB
14 acute cystitis 30.2 H2AC18 CRP ALB
15 dysentery 30.2 PRDM10 HUWE1 H2AC18 CRP ALB
16 bacterial pneumonia 30.2 H2AC18 CRP ALB
17 bone resorption disease 30.1 H2AC18 CRP ALB
18 neuromuscular disease 30.0 PRDM10 H2AC18 GAPDH ALB ACTB
19 myeloma, multiple 30.0 PRDM10 H2AC18 GAPDH CRP ALB ACTB
20 subacute bacterial endocarditis 29.9 CRP ALB
21 body mass index quantitative trait locus 11 29.7 PRDM10 H2AC18 GAPDH CRP ALB ACTB
22 eye disease 29.6 TNFRSF10C PRDM10 HUWE1 H2AC18 GAPDH CRP
23 acute canaliculitis 12.5
24 chronic canaliculitis 12.4
25 hidradenitis suppurativa 11.7
26 bagassosis 11.5
27 cholera 11.5
28 carbuncle 11.5
29 olecranon bursitis 11.3
30 ventilation pneumonitis 11.2
31 mushroom workers' lung 11.2
32 hypermethioninemia 11.2
33 biotin deficiency 11.2
34 perichondritis of auricle 11.2
35 agammaglobulinemia 11.2
36 prion disease 11.2
37 primary agammaglobulinemia 11.2
38 haemonchiasis 10.6 PRDM10 HUWE1
39 chronic duodenal ileus 10.6 CRP ALB
40 syphilitic encephalitis 10.6 PRDM10 C1orf210
41 adult brain stem glioma 10.6 H3-3B H3-3A
42 bone giant cell sarcoma 10.6 H3-3B H3-3A
43 malignant giant cell tumor 10.6 H3-3B H3-3A
44 tuberculous peritonitis 10.5 CRP ALB
45 spinal cord astrocytoma 10.5 H3-3B H3-3A
46 subacute glomerulonephritis 10.5 ALB ACTB
47 hereditary elliptocytosis 10.5 ADD3 ADD2 ADD1
48 pneumoconiosis due to talc 10.5 H3-3B H3-3A
49 ascending cholangitis 10.5 CRP ALB
50 renal infectious disease 10.5 HUWE1 CRP

Graphical network of the top 20 diseases related to Actinomycosis:



Diseases related to Actinomycosis

Symptoms & Phenotypes for Actinomycosis

Drugs & Therapeutics for Actinomycosis

Drugs for Actinomycosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Simethicone Approved Phase 4 8050-81-5
2
Budesonide Approved Phase 4 51333-22-3 63006 5281004
3
Povidone-iodine Approved Phase 4 25655-41-8
4
Iodine Approved, Investigational Phase 4 7553-56-2 807
5
Povidone Approved Phase 4 9003-39-8
6
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
7
Ciclopirox Approved, Investigational Phase 4 29342-05-0 2749
8
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
9
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
10 Anti-Infective Agents Phase 4
11 Aluminum hydroxide, magnesium hydroxide, drug combination Phase 4
12 Emollients Phase 4
13 Dermatologic Agents Phase 4
14 Anti-Inflammatory Agents Phase 4
15 Anti-Infective Agents, Local Phase 4
16 Plasma Substitutes Phase 4
17 Blood Substitutes Phase 4
18 cadexomer iodine Phase 4
19 Respiratory System Agents Phase 4
20 Hormones Phase 4
21 Anti-Asthmatic Agents Phase 4
22 Hormone Antagonists Phase 4
23 glucocorticoids Phase 4
24 Bronchodilator Agents Phase 4
25 Chlorhexidine gluconate Phase 4
26 Disinfectants Phase 4
27 Antifungal Agents Phase 4
28
Oxytetracycline Approved, Investigational, Vet_approved Phase 3 79-57-2 54715139 5280972
29
Adalimumab Approved Phase 3 331731-18-1 16219006
30 Antirheumatic Agents Phase 3
31 Nigella Phase 1, Phase 2
32
Iron Approved, Experimental 15438-31-0, 7439-89-6 27284 23925
33
Turmeric Approved, Experimental, Investigational
34
Hydrogen peroxide Approved, Vet_approved 7722-84-1 784
35
Acetaminophen Approved 103-90-2 1983
36
Oxytocin Approved, Vet_approved 50-56-6 53477758 439302
37
Caffeine Approved 58-08-2 2519
38
Vitamin A Approved, Nutraceutical, Vet_approved 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
39
Ethylene 74-85-1 6325
40 Turmeric extract
41 Floxacillin
42 Analgesics, Non-Narcotic
43 Antipyretics
44 penicillins
45 Analgesics
46 Senna
47 Sennoside A&B
48 Fibrin fragment D
49 Pharmaceutical Solutions
50 Retinol palmitate

Interventional clinical trials:

(show all 35)
# Name Status NCT ID Phase Drugs
1 A Double Blinded Randomized Controlled Trial for the Management of Pediatric Community Acquired Skin Abscesses - To Treat or Not to Treat With Antibiotics Completed NCT00679302 Phase 4 Trimethoprim-sulfamethoxazole;Placebo group
2 Steroid Nasal Irrigation for Flavor Evaluation and Detection (SNIFFED) Study Completed NCT02985515 Phase 4
3 Skin and Soft Tissue Infection (SSTI) Study Completed NCT02600871 Phase 4 Provodine
4 The Impact Of The Addition Of Budesonide To Low-Pressure, High-Volume Saline Sinus Irrigation For Chronic Rhinosinusitis Completed NCT02696850 Phase 4 Budesonide;Saline alone
5 Clinical Trial of the Effectiveness of Chlorhexidine Gluconate 0.125 % Compared With Sterile Deionized Water in the Closure of Diabetic Foot Ulcer Syndrome. Completed NCT02097615 Phase 4
6 Study for the Assessment of Safety and Efficacy of Ciclopirox Olamine Cream in 3 Months to 10 Years Old Children With Dermatomycoses Terminated NCT01646580 Phase 4 ciclopirox
7 Multicenter Clinical Study,Phase III, Prospective, Randomized, Open and Comparative to Measure Tolerability and Efficacy of Taro Elixir on the Evolution Treatment of Acne Vulgaris II and III Degree or of Furunculosis Compared With Oxytetracycline Unknown status NCT01032499 Phase 3 oxytetracycline, taro elixir;Taro Elixir
8 A Phase 3 Multicenter Study of the Safety and Efficacy of Adalimumab in Subjects With Moderate to Severe Hidradenitis Suppurativa - PIONEER II Completed NCT01468233 Phase 3
9 A Phase 3 Multicenter Study of the Safety and Efficacy of Adalimumab in Subjects With Moderate to Severe Hidradenitis Suppurativa - PIONEER I Completed NCT01468207 Phase 3
10 Effectiveness of Nigella Sativa (Kalonji) Seed in Dyslipidemia: A Randomized Controlled Trial Completed NCT00327054 Phase 1, Phase 2 Nigella sativa seed
11 Diet-Induced Thermogenesis: A Comparison of Whole and Processed Foods Completed NCT02943434 Phase 1
12 Assessment of Salivary Bacterial Level and Dental Caries Experience in a Group of Egyptian Children With Black Stained Teeth: A Cross Sectional Study Unknown status NCT03563469
13 A Multi-center, Non-randomized, Open, Single-arm Confirmatory Clinical Study to Evaluate the Safety and Efficacy of Surgical Material for Nasal Septoplasty in Septal Deformity Patients With Nasal Obstruction Unknown status NCT03088618
14 Lacrimal Sac Dacryoliths (86 Samples): Chemical and Mineralogic Analyses Completed NCT01826734
15 Abscess Packing Versus Wick Placement After Incision and Drainage Completed NCT01281930
16 Studying the Tissue Microenvironment Signatures of the Mycetoma Granuloma Completed NCT04401969
17 Role of Udumbara Sutra in the Management of Fistula in Ano a Rare Case Study Completed NCT01954225
18 Speech Performance of Rugby Players When Using Different Types of Mouthguard Completed NCT04010500
19 A Randomized Clinical Trial Comparing Use of Rapid Molecular Testing for Staphylococcus Aureus for Patients With Cutaneous Abscesses in the Emergency Department With Standard of Care. Completed NCT01523899
20 Epidemiology and Pulmonary Response To Organic Dust Exposure Completed NCT00005288
21 Cooking With Iron Ingots: Assessing Feasibility and Natural History Among Infants in Resource-limited Settings Completed NCT03606993
22 Case Study of Fistula in Ano Managed by Kshar Sutra, Para Surgical Procedure Completed NCT01880398
23 The Safe Start Trial: a Cluster Randomised Controlled Trial for the Effect of a Food Hygiene Intervention on Infant Enteric Infections and Diarrhoeal Disease in Low-income Informal Settlements of Kisumu, Kenya. Completed NCT03468114
24 Speech Adaptation When Using Mouthguards Completed NCT04064099
25 Single Case Study of Vaginal Fistula Managed by Kshar Sutra, a Minimal Invasive Treatment. Completed NCT01864473
26 A RCT in Sweden of Acupuncture and Care Interventions for the Relief of Inflammatory Symptoms of the Breast During Lactation Completed NCT00405158 Anti-pyretic medication, paracetamol;cefadroxil;penicillin;flucloxacillin
27 Influence of Different Doses of Coffee in the Blood Pressure Response Post-exercise Completed NCT02335840
28 Senna Alata Leaf Decoction as a Treatment for Tinea Imbricata in an Indigenous Tribe in Southern Philippines :a Pilot Study Completed NCT03745183
29 Surveillance of Community-Associated MRSA and Treatment Outcomes of Skin and Soft Tissue Infections in the Ambulatory Setting Recruiting NCT04083092
30 The Effect of miRNA and Epigenetic Modifications on Prognosis in Covid-19 Infection Recruiting NCT04411563
31 CHoBI7 Trial: A Hospital Based Water, Sanitation and Hygiene Intervention for Households of Diarrheal Patients in Bangladesh Active, not recruiting NCT04008134
32 Clinical Extend Study to Evaluate Safety and Effectiveness of TnR Nasal Mesh for Correction of Nasal Septum on Patients Who Need Correction of Nasal Septum That Accompanies With Rhinanchone Symptom Not yet recruiting NCT04332575
33 Study Protocol for A Randomized Controlled Trial of Incision and Drainage Versus Ultrasound-Guided Needle Aspiration for Uncomplicated Skin Abscesses Not yet recruiting NCT04127071
34 Spatial Analysis and Validation of Glioblastoma on 7 T MRI Terminated NCT02062372
35 The Use of Adjuvant Antibiotic Therapy After Incision and Drainage for Pediatric Abscess: A Prospective, Randomized, Double-blinded, Placebo-Controlled Trial Withdrawn NCT00900510 Trimethoprim/Sulfamethoxazole (Bactrim);Placebo

Search NIH Clinical Center for Actinomycosis

Cochrane evidence based reviews: actinomycosis

Genetic Tests for Actinomycosis

Anatomical Context for Actinomycosis

MalaCards organs/tissues related to Actinomycosis:

40
Lung, Colon, Skin, Liver, Testes, Bone, Breast

Publications for Actinomycosis

Articles related to Actinomycosis:

(show top 50) (show all 4348)
# Title Authors PMID Year
1
Abdominal Actinomycosis After Bariatric Surgery. 61
32557388 2020
2
A Case Report of Pelvic Actinomycosis and a Literature Review. 61
32532952 2020
3
Ocular Actinomycosis Mimicking Meningioma. 61
32529000 2020
4
Cervicofacial actinomycosis of the mandible in a paediatric patient. 61
32467116 2020
5
Suppurative cervical lymphadenitis in adult: An analysis of predictors for surgical drainage. 61
32370913 2020
6
A rare case of brain abscess caused by Actinomyces meyeri. 61
32460724 2020
7
A rare case of Actinomyces skin and soft tissue infection in an end-stage kidney disease patient with a review of the literature. 61
32458569 2020
8
Cervicofacial actinomycosis: a report of 14 patients observed at the Dermatology Unit of the University of Milan, Italy. 61
32403186 2020
9
Caecum actinomycosis with acute abdomen: A case report. 61
32368212 2020
10
A difficult disease to diagnosis: Pulmonary actinomycosis. 61
31854106 2020
11
Primary urachal actinomycosis: A literature review. 61
31924416 2020
12
Successful Limb Salvage in a Case of Advanced Long-Standing Eumycetoma of the Foot Using Adjunctive Local Amphotericin B Delivery Through Bioabsorbable Beads. 61
32257041 2020
13
A scoring system based on computed tomography for the correct diagnosis of xanthogranulomatous cholecystitis. 61
32313694 2020
14
Bony cystic lesion with associated submandibular lymphadenopathy on a background of breast carcinoma: an unexpected case of cervicofacial actinomycosis. 61
32265208 2020
15
Unusual aetiology of lymphocyte-predominant exudative pleural effusion: primary mediastinal actinomycosis. 61
32148837 2020
16
Laryngeal Actinomycosis: A Rare Cause of Dysphonia. 61
30943809 2020
17
Nasal Septum Actinomycosis Mimicking Mucocele. 61
31688262 2020
18
Pelvic Actinomycosis in a Pregnant Woman Misdiagnosed as Placental Implantation. 61
32212407 2020
19
Actinomycetoma of the hand: a case report. 61
31069882 2020
20
Actinomycetoma caused by Gordonia westfalica: first reported case of human infection. 61
32194964 2020
21
Esophageal actinomycosis mimicking a carcinoma. 61
31960679 2020
22
Cutaneous nocardiosis: A great imitator. 61
32513396 2020
23
Disseminated Actinomycosis A Rare Cause of Abdominal Pain: A Case Report. 61
32395260 2020
24
Successful Treatment of Recalcitrant Actinomycetoma of Gluteal Area with Combined Medical Treatment and Surgical Excision with Graft Reconstruction. 61
32308989 2020
25
Esophageal Actinomycosis in an End-Stage Renal Disease Patient: What Can We Expect to See? 61
31809295 2020
26
Cervicofacial actinomycosis. 61
32162331 2020
27
Actinomycosis of the Tongue: A Case Report and Review of Literature. 61
32187989 2020
28
Added-Value of Endometrial Biopsy in the Diagnostic and Therapeutic Strategy for Pelvic Actinomycosis. 61
32197366 2020
29
Diagnosis and Management of Cervicofacial Actinomycosis: Lessons from Two Distinct Clinical Cases. 61
32218154 2020
30
Actinomycosis of the appendix mimicking cecal tumor treated by single-port laparoscopic approach. 61
32178493 2020
31
Diversity and geographic distribution of soil streptomycetes with antagonistic potential against actinomycetoma-causing Streptomyces sudanensis in Sudan and South Sudan. 61
32050891 2020
32
Clinical characteristics and treatment of actinomycetoma in northeast Mexico: A case series. 61
32097417 2020
33
Actinomycetoma Caused by Actinomadura mexicana, A Neglected Entity in the Caribbean. 61
31961313 2020
34
Hepatic actinomycosis - A potential mimicker of malignancy. 61
31762867 2020
35
Esophageal Actinomycosis Masquerading as Cancer in an Immunocompetent Patient. 61
32309511 2020
36
Microstructural analysis of bony alterations in a historic case of actinomycosis. 61
32109842 2020
37
Thoracic and Renal Actinomycosis Requiring Complete Right Nephrectomy in a Costa Rican Female Child. 61
32190442 2020
38
Abdominal actinomycosis in an elderly diabetic. 61
31933616 2020
39
Surgical endodontics for management of progressive actinomycosis. 61
31859665 2020
40
Clinicopathological and ultrastructural characterization of periapical actinomycosis. 61
31880281 2020
41
Image screening for maxillo-mandibular actinomycosis with CT, 18F-FDG-PET/CT, and 18F-α-methyl tyrosine PET/CT. 61
31925626 2020
42
Renal actinomycosis presenting as uro-cutaneous fistula. 61
31709154 2020
43
Mycetoma epidemiology, diagnosis management, and outcome in three hospital centres in Senegal from 2008 to 2018. 61
32330155 2020
44
Madurella mycetomatis infection of the foot: a case report of a neglected tropical disease in a non-endemic region. 61
31918687 2020
45
Climate, soil type, and geographic distribution of actinomycetoma cases in Northeast Mexico: A cross-sectional study. 61
32384126 2020
46
Actinomycosis as a Rare Local Manifestation of Severe Periodontitis. 61
32089900 2020
47
Abdominal Actinomycosis misdiagnosed as liposarcoma. 61
32039066 2020
48
[Thoracal actinomycosis - a diagnostic challenge]. 61
31821519 2019
49
Post-transplantation laryngeal actinomycosis. 61
30579693 2019
50
Pulmonary lesions associated with sputum culture-positive actinomycetes: report of one case. 61
32042809 2019

Variations for Actinomycosis

Expression for Actinomycosis

Search GEO for disease gene expression data for Actinomycosis.

Pathways for Actinomycosis

Pathways related to Actinomycosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.08 ADD3 ADD2 ADD1

GO Terms for Actinomycosis

Cellular components related to Actinomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoskeleton GO:0005856 9.8 WASHC1 GAPDH FRY ADD3 ADD2 ADD1
2 F-actin capping protein complex GO:0008290 9.16 ADD2 ADD1
3 Barr body GO:0001740 8.96 H3-3B H3-3A
4 plasma membrane raft GO:0044853 8.8 ADD3 ADD2 ADD1

Biological processes related to Actinomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multicellular organism growth GO:0035264 9.61 H3-3B H3-3A ADD1
2 actin filament bundle assembly GO:0051017 9.5 ADD3 ADD2 ADD1
3 negative regulation of mitochondrial fusion GO:0010637 9.4 MUL1 HUWE1
4 pericentric heterochromatin assembly GO:0031508 9.37 H3-3B H3-3A
5 regulation of centromere complex assembly GO:0090230 9.26 H3-3B H3-3A
6 negative regulation of chromosome condensation GO:1902340 9.16 H3-3B H3-3A
7 telomeric heterochromatin assembly GO:0031509 8.96 H3-3B H3-3A
8 barbed-end actin filament capping GO:0051016 8.8 ADD3 ADD2 ADD1

Molecular functions related to Actinomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.87 WRNIP1 MUL1 GAPDH CRP COIL ALB
2 protein heterodimerization activity GO:0046982 9.65 H3-3B H3-3A H2AC18 ADD2 ADD1
3 nucleosomal DNA binding GO:0031492 9.33 H3-3B H3-3A ACTB
4 spectrin binding GO:0030507 9.13 ADD3 ADD2 ADD1
5 structural constituent of cytoskeleton GO:0005200 8.92 ADD3 ADD2 ADD1 ACTB

Sources for Actinomycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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