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MCID: ACT058
MIFTS: 52

Active Peptic Ulcer Disease

Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Active Peptic Ulcer Disease

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MalaCards integrated aliases for Active Peptic Ulcer Disease:

Name: Active Peptic Ulcer Disease 12 15
Gi Bleeding 12 15
Gastrointestinal Hemorrhage 73
Active Peptic Ulcer 73

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:749
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Summaries for Active Peptic Ulcer Disease

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MalaCards based summary : Active Peptic Ulcer Disease, also known as gi bleeding, is related to peptic ulcer disease and gastric antral vascular ectasia, and has symptoms including nausea and vomiting, constipation and fever. An important gene associated with Active Peptic Ulcer Disease is ATP12A (ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit), and among its related pathways/superpathways are Selenium Micronutrient Network and Salivary secretion. The drugs Misoprostol and Lansoprazole have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and heart, and related phenotypes are digestive/alimentary and homeostasis/metabolism

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Related Diseases for Active Peptic Ulcer Disease

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Diseases related to Active Peptic Ulcer Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 177)
# Related Disease Score Top Affiliating Genes
1 peptic ulcer disease 30.4 ATP4A HRH2 PTGS2
2 gastric antral vascular ectasia 30.0 ATP12A ATP4A
3 duodenitis 30.0 ATP12A ATP4A
4 esophagitis 29.9 HRH2 PTGS2
5 varicose veins 29.8 F2 VWF
6 thrombophilia due to thrombin defect 29.6 F2 VWF
7 portal hypertension 29.3 F2 VWF
8 myocardial infarction 29.2 F2 PTGS1 PTGS2 VWF
9 fungal esophagitis 10.2 ATP12A ATP4A
10 diclofenac allergy 10.2 ATP12A ATP4A
11 gastroduodenal crohn's disease 10.2 ATP12A ATP4A
12 neonatal candidiasis 10.2 ATP12A ATP4A
13 squamous papillomatosis 10.2 ATP12A ATP4A
14 toxic megacolon 10.2 ATP12A ATP4A
15 gastrointestinal neuroendocrine benign tumor 10.2 ATP12A ATP4A
16 granulomatous gastritis 10.2 ATP12A ATP4A
17 esophageal candidiasis 10.2 ATP12A ATP4A
18 gastric neuroendocrine neoplasm 10.2 ATP12A ATP4A
19 acute laryngitis 10.2 ATP12A ATP4A
20 rumination disorder 10.2 ATP12A ATP4A
21 congenital disorder of deglycosylation 10.2 ATP12A ATP4A
22 bladder calculus 10.2 ATP12A ATP4A
23 capillary disease 10.2 ATP12A ATP4A
24 dyskinesia of esophagus 10.2 ATP12A ATP4A
25 hernia, hiatus 10.2 ATP12A ATP4A
26 anismus 10.2 ATP12A ATP4A
27 postsurgical hypothyroidism 10.2 ATP12A ATP4A
28 lymphocytic colitis 10.2 ATP12A ATP4A
29 esophageal atresia/tracheoesophageal fistula 10.2 ATP12A ATP4A
30 clostridium difficile colitis 10.2 ATP12A ATP4A
31 diarrhea 1, secretory chloride, congenital 10.2 ATP12A ATP4A
32 microscopic colitis 10.2 ATP12A ATP4A
33 laryngeal tuberculosis 10.2 ATP12A ATP4A
34 eosinophilic gastritis 10.2 ATP12A ATP4A
35 chronic intestinal vascular insufficiency 10.2 ATP12A ATP4A
36 polyposis, skin pigmentation, alopecia, and fingernail changes 10.2 ATP12A ATP4A
37 jejunoileitis 10.2 ATP12A ATP4A
38 pancreatic steatorrhea 10.2 ATP12A ATP4A
39 superior mesenteric artery syndrome 10.2 ATP12A ATP4A
40 duodenal disease 10.2 ATP12A ATP4A
41 gastric lymphoma 10.2 ATP12A ATP4A
42 lower urinary tract calculus 10.2 ATP12A ATP4A
43 myopathy, x-linked, with excessive autophagy 10.2 ATP12A ATP4A
44 aspiration pneumonia 10.2 ATP12A ATP4A
45 pneumatosis cystoides intestinalis 10.2 ATP12A ATP4A
46 lateral medullary syndrome 10.2 ATP12A ATP4A
47 microinvasive gastric cancer 10.2 ATP12A ATP4A
48 osteopetrosis, autosomal recessive 3 10.2 ATP12A ATP4A
49 paine syndrome 10.2 ATP12A ATP4A
50 esophagitis, eosinophilic, 1 10.2 ATP12A ATP4A

Comorbidity relations with Active Peptic Ulcer Disease via Phenotypic Disease Network (PDN): (show top 50) (show all 147)


Acquired Thrombocytopenia Acute Cystitis
Acute Kidney Failure Acute Myocardial Infarction
Acute Pancreatitis Acute Vascular Insufficiency of Intestine
Alcohol Abuse Alcoholic Gastritis
Alcoholic Hepatitis Alcoholic Liver Cirrhosis
Alzheimer Disease Anus Disease
Aortic Valve Disease 1 Ascending Colon Cancer
Atrophic Gastritis Bacteremia 2
Benign Essential Hypertension Bleeding Disorder, Platelet-Type, 11
Bronchitis Bronchopneumonia
Candidiasis Cardiac Arrest
Cardiogenic Shock Cecal Benign Neoplasm
Cerebral Atherosclerosis Cerebrovascular Disease
Cholestasis Chronic Intestinal Vascular Insufficiency
Chronic Kidney Failure Chronic Myocardial Ischemia
Chronic Pulmonary Heart Disease Chronic Ulcer of Skin
Chylomicron Retention Disease Colon Carcinoma in Situ
Colorectal Cancer Conjunctivitis
Crohn's Disease Cystitis
Decubitus Ulcer Deficiency Anemia
Dermatomycosis Descending Colon Cancer
Disseminated Intravascular Coagulation Duodenitis
Duodenum Cancer Dysthymic Disorder
Encephalopathy Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Esophageal Cancer Esophageal Candidiasis

Graphical network of the top 20 diseases related to Active Peptic Ulcer Disease:



Diseases related to Active Peptic Ulcer Disease
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Symptoms & Phenotypes for Active Peptic Ulcer Disease

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UMLS symptoms related to Active Peptic Ulcer Disease:


nausea and vomiting, constipation, fever, vomiting, fatigue, abdominal pain, edema, pruritus, hemoptysis, pain, chest pain, diarrhea, headache, syncope, nausea, chronic pain, sciatica, pelvic pain, coughing, icterus, vertigo/dizziness, dyspepsia, heartburn, gastrointestinal gas, symptoms, halitosis, digestive system symptom, blood in stool

MGI Mouse Phenotypes related to Active Peptic Ulcer Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.76 ATP12A ATP4A F2 HRH2 PTGS1 PTGS2
2 homeostasis/metabolism MP:0005376 9.56 ATP12A ATP4A F2 HRH2 PTGS1 PTGS2
3 immune system MP:0005387 9.1 ATP4A F2 PTGS1 PTGS2 SLC9A4 VWF
Sources

Drugs & Therapeutics for Active Peptic Ulcer Disease

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Drugs for Active Peptic Ulcer Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Misoprostol Approved Phase 4 59122-46-2 5282381
2
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
3
Dexlansoprazole Approved, Investigational Phase 4 103577-45-3, 138530-94-6 9578005
4 Anti-Ulcer Agents Phase 4
5 Oxytocics Phase 4
6 Antacids Phase 4
7 Gastrointestinal Agents Phase 4,Phase 3
8
Ketorolac Approved Phase 3 66635-83-4, 74103-06-3 3826
9
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
10
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
11
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
12 Autonomic Agents Phase 3,Not Applicable
13 Peripheral Nervous System Agents Phase 3,Not Applicable
14 BB 1101 Phase 3
15
protease inhibitors Phase 3
16 Ketorolac Tromethamine Phase 3
17 Analgesics, Non-Narcotic Phase 3
18 glucocorticoids Phase 3
19 Liver Extracts Phase 3
20 Hormones Phase 3
21 Hormone Antagonists Phase 3
22 Dexamethasone 21-phosphate Phase 3
23 Analgesics Phase 3
24 Antineoplastic Agents, Hormonal Phase 3
25 Anti-Inflammatory Agents, Non-Steroidal Phase 3
26 Antirheumatic Agents Phase 3
27 Anti-Inflammatory Agents Phase 3
28 HIV Protease Inhibitors Phase 3
29 Antiemetics Phase 3
30 Cyclooxygenase Inhibitors Phase 3
31 Analgesics, Opioid Phase 3
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
33
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
34
Racepinephrine Approved Not Applicable 329-65-7 838
35 Sympathomimetics Not Applicable
36 Bronchodilator Agents Not Applicable
37 Vasoconstrictor Agents Not Applicable
38 Adrenergic beta-Agonists Not Applicable
39 Anti-Asthmatic Agents Not Applicable
40 Adrenergic Agonists Not Applicable
41 Epinephryl borate Not Applicable
42 Mydriatics Not Applicable
43 Coagulants Not Applicable
44 Adrenergic alpha-Agonists Not Applicable
45 Respiratory System Agents Not Applicable
46 Hemostatics Not Applicable
47 Neurotransmitter Agents Not Applicable
48 Adrenergic Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prevention of Recurrent Ulcer Bleeding in Patients With Idiopathic Gastroduodenal Ulcer Recruiting NCT03675672 Phase 4 Misoprostol Oral Tablet;Placebo Oral Tablet
2 Dexamethasone Versus Ketorolac Injection for the Treatment of Local Inflammatory Hand and Upper Extremity Disorders Recruiting NCT02266433 Phase 3 Ketorolac;Dexamethasone
3 Efficacy of Hemostasis by Soft Coagulation Using Endoscopic Hemostatic Forceps for Acute Peptic Ulcer Bleeding Completed NCT02020603 Not Applicable

Search NIH Clinical Center for Active Peptic Ulcer Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :
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Genetic Tests for Active Peptic Ulcer Disease

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Anatomical Context for Active Peptic Ulcer Disease

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MalaCards organs/tissues related to Active Peptic Ulcer Disease:

41
Liver, Lung, Heart, Bone, Skin, Colon, Small Intestine
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Publications for Active Peptic Ulcer Disease

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Articles related to Active Peptic Ulcer Disease:

(show top 50) (show all 412)
# Title Authors Year
1
A novel, duodenoscope-friendly endoscopic clip for treating massive upper-GI bleeding secondary to a Dieulafoy lesion. ( 30128389 )
2018
2
Upper GI Bleeding in Cirrhotic Patients: Which Method to Search for Helicobacter Pylori Infection? ( 29888786 )
2018
3
GI Bleeding (Abstracts 530-567). ( 30297920 )
2018
4
GI Bleeding. ( 30297926 )
2018
5
Clinical Vignettes/Case Reports - GI Bleeding. ( 30297942 )
2018
6
Clinical Vignettes/Case Reports - GI Bleeding. ( 30315289 )
2018
7
Outcomes and Predictors of Readmissions with GI Bleeding in Patients with Left Ventricular Assist Devices. ( 30392001 )
2018
8
The utility of intravenous heparin to aid diagnosis and intervention in obscure GI bleeding. ( 30449413 )
2018
9
Chronic GI bleeding in a middle-aged woman. ( 30554158 )
2018
10
Acute lower GI bleeding in the UK: patient characteristics, interventions and outcomes in the first nationwide audit. ( 28148540 )
2018
11
Therapeutic endoscopy-related GI bleeding and thromboembolic events in patients using warfarin or direct oral anticoagulants: results from a large nationwide database analysis. ( 28874418 )
2018
12
Life-threatening GI bleeding secondary to multiple gastric metastases from urothelial carcinoma of the renal pelvis. ( 29102733 )
2018
13
Prognostic factors affecting outcomes in patients with malignant GI bleeding treated with a novel endoscopically delivered hemostatic powder. ( 29158179 )
2018
14
Metastatic renal cell carcinoma to the small bowel: three cases of GI bleeding and a literature review. ( 29185198 )
2018
15
A Novel Technique to Measure the Intensity of Abnormality on GI Bleeding Scans: Development, Initial Implementation, and Correlation With Conventional Angiography. ( 29215411 )
2018
16
Subacute Upper GI Bleeding Due To Infected Aortic Graft with Aorto-Duodenal Fistula. ( 29512003 )
2018
17
Blood urea nitrogen increase is an expected finding in nonvariceal upper GI bleeding patients with underlying moderate or severe renal disease. ( 29655440 )
2018
18
GI Bleeding Risk of DOACs Versus Warfarin: Is Newer Better? ( 29671162 )
2018
19
Non-variceal upper GI bleeding. ( 29671414 )
2018
20
GI Bleeding During CF-LVAD Support: State of the Field. ( 29746258 )
2018
21
Metastatic hepatocellular carcinoma of small bowel presenting as GI bleeding. ( 29908177 )
2018
22
A randomized controlled trial comparing efficacy of early video capsule endoscopy with standard of care in the approach to nonhematemesis GI bleeding (with videos). ( 29935143 )
2018
23
Treatment of thrombocytopenic patients with GI bleeding. ( 29935628 )
2018
24
Acquired Factor VIII Inhibitor Presenting as Occult GI Bleeding. ( 30018830 )
2018
25
Endoscopic Therapy for Upper GI Bleeding on Antithrombotics - A Safe Option or Do Questions Remain? ( 30036644 )
2018
26
The Hemodynamic Profile of GI Bleeding in Continuous-Flow LVADs: Is it All About the Right Ventricle? ( 30076881 )
2018
27
Double-lumen duodenum with obscure overt GI bleeding. ( 30128382 )
2018
28
First UK data for CT angiography in persisting upper GI bleeding. ( 30245799 )
2018
29
EUS-guided arterial embolization with cyanoacrylate glue of a pancreatic neuroendocrine tumor infiltrating the gastric wall causing upper GI bleeding. ( 29905271 )
2017
30
Can Nonvalidated Lower GI Bleeding Predictive Scores be Evaluated by Receiver Operator Characteristics? ( 27253465 )
2017
31
Pharmacologic provocation combined with endoscopy in refractory cases of GI bleeding. ( 27343413 )
2017
32
Foiled by coils: upper GI bleeding from a rare delayed adverse event of transarterial embolization. ( 27443967 )
2017
33
Timing of upper endoscopy influences outcomes in patients with acute nonvariceal upper GI bleeding. ( 27693643 )
2017
34
Thinking out of the Gut: a case of obscure lower GI bleeding. ( 27965282 )
2017
35
A rare cause of GI bleeding in a 56-year-old man. ( 27998985 )
2017
36
Association of prophylactic endotracheal intubation in critically ill patients with upper GI bleeding and cardiopulmonary unplanned events. ( 28011279 )
2017
37
Negative result of capsule endoscopy in obscure GI bleeding: searching in the dark despite bright lights. ( 28089030 )
2017
38
Urgent colonoscopy in patients with lower GI bleeding: a systematic review and meta-analysis. ( 28174123 )
2017
39
Super-Selective Mesenteric Embolization Provides Effective Control of Lower GI Bleeding. ( 28210507 )
2017
40
Association between an increase in blood urea nitrogen at 24 hours and worse outcomes in acute nonvariceal upper GI bleeding. ( 28377105 )
2017
41
Relationship of time to presentation after onset of upper GI bleeding with patient characteristics and outcomes: a prospective study. ( 28396275 )
2017
42
Is timing everything in the management of acute upper GI bleeding? ( 28411763 )
2017
43
Glasgow Blatchford score predicted intervention or death better than 4 other prediction models in upper GI bleeding. ( 28418549 )
2017
44
The role of early colonoscopy in acute lower GI bleeding: summarizing conflicting data in the presence of society recommendations. ( 28610853 )
2017
45
Apixaban may have lower risk of GI bleeding compared with dabigatran and rivaroxaban in patients with atrial fibrillation. ( 28705921 )
2017
46
In high-risk patients with arthritis and previous upper GI bleeding, celecoxib vs naproxen reduced recurrent bleeding. ( 28806798 )
2017
47
In nonvalvular AF, DOAC-related risk for GI bleeding was lower with apixaban than dabigatran or rivaroxaban. ( 28806802 )
2017
48
Capsule endoscopy in obscure GI bleeding: better to be negative, but let us not be too positive. ( 28826553 )
2017
49
ERCP-related complication is not the only cause of GI bleeding in post-liver transplantation patients: A case report. ( 28906357 )
2017
50
Ectopic Duodenal Varices: A rare cause of upper GI bleeding. ( 28952680 )
2017
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Variations for Active Peptic Ulcer Disease

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Expression for Active Peptic Ulcer Disease

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Search GEO for disease gene expression data for Active Peptic Ulcer Disease.
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Pathways for Active Peptic Ulcer Disease

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Pathways related to Active Peptic Ulcer Disease according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Selenium Micronutrient Network 1
Show member pathways
 11.97 F2 PTGS1 PTGS2
2
Salivary secretion 37
Show member pathways
 11.65 ATP4A HRH2 SLC9A4
3
Celecoxib Pathway, Pharmacodynamics 61
11.3 PTGS1 PTGS2
4
Regulation of lipolysis in adipocytes 37
11.26 PTGS1 PTGS2
5
Proton Pump Inhibitor Pathway, Pharmacodynamics 61
11.17 ATP4A HRH2
6
Prostaglandin Synthesis and Regulation 1
10.97 PTGS1 PTGS2
7
Ibuprofen Pathway, Pharmacodynamics 61
10.92 PTGS1 PTGS2
8
HETE and HPETE biosynthesis and metabolism 22
Show member pathways
 10.86 PTGS1 PTGS2
9
Eicosanoid Synthesis 1
10.78 PTGS1 PTGS2
10
Prostaglandin 2 biosynthesis and metabolism FM 22
10.73 PTGS1 PTGS2
11
Overview of nanoparticle effects 1
10.6 PTGS1 PTGS2
12
Platelet Aggregation Inhibitor Pathway, Pharmacodynamics 61
10.51 F2 PTGS1 VWF
13
Etoposide Pathway, Pharmacokinetics/Pharmacodynamics 61
10.33 PTGS1 PTGS2
14
Secretion of Hydrochloric Acid in Parietal Cells 1
9.65 ATP4A HRH2
Sources

GO Terms for Active Peptic Ulcer Disease

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Biological processes related to Active Peptic Ulcer Disease according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 regulation of blood pressure GO:0008217 9.56 PTGS1 PTGS2
2 hemostasis GO:0007599 9.55 F2 VWF
3 potassium ion import across plasma membrane GO:1990573 9.54 ATP12A ATP4A
4 potassium ion import GO:0010107 9.52 ATP12A ATP4A
5 positive regulation of vasoconstriction GO:0045907 9.51 HRH2 PTGS2
6 ATP hydrolysis coupled proton transport GO:0015991 9.49 ATP12A ATP4A
7 prostaglandin metabolic process GO:0006693 9.48 PTGS1 PTGS2
8 regulation of pH GO:0006885 9.46 ATP12A SLC9A4
9 blood coagulation, intrinsic pathway GO:0007597 9.43 F2 VWF
10 sodium ion transport GO:0006814 9.43 ATP12A ATP4A SLC9A4
11 cellular sodium ion homeostasis GO:0006883 9.4 ATP12A ATP4A
12 prostaglandin biosynthetic process GO:0001516 9.37 PTGS1 PTGS2
13 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.32 ATP12A ATP4A
14 cellular potassium ion homeostasis GO:0030007 9.16 ATP12A ATP4A
15 sodium ion export across plasma membrane GO:0036376 8.96 ATP12A ATP4A
16 cyclooxygenase pathway GO:0019371 8.62 PTGS1 PTGS2

Molecular functions related to Active Peptic Ulcer Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxidase activity GO:0004601 9.26 PTGS1 PTGS2
2 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP12A ATP4A
3 potassium:proton exchanging ATPase activity GO:0008900 8.96 ATP12A ATP4A
4 prostaglandin-endoperoxide synthase activity GO:0004666 8.62 PTGS1 PTGS2
Sources

Sources for Active Peptic Ulcer Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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