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MCID: ACT058
MIFTS: 42

Active Peptic Ulcer Disease

Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Active Peptic Ulcer Disease

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MalaCards integrated aliases for Active Peptic Ulcer Disease:

Name: Active Peptic Ulcer Disease 12 15
Gastrointestinal Hemorrhage 73
Active Peptic Ulcer 73
Gi Bleeding 12

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:749
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Summaries for Active Peptic Ulcer Disease

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MalaCards based summary : Active Peptic Ulcer Disease, also known as gastrointestinal hemorrhage, is related to duodenitis and peptic ulcer disease, and has symptoms including abdominal pain, chest pain and constipation. An important gene associated with Active Peptic Ulcer Disease is ATP12A (ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit), and among its related pathways/superpathways are Folate Metabolism and Salivary secretion. The drugs Lidocaine and Ketorolac have been mentioned in the context of this disorder. Affiliated tissues include liver, and related phenotypes are digestive/alimentary and homeostasis/metabolism

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Related Diseases for Active Peptic Ulcer Disease

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Diseases related to Active Peptic Ulcer Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 duodenitis 30.9 ATP12A ATP4A
2 peptic ulcer disease 30.3 ATP4A HRH2 PTGS2
3 esophagitis 30.1 HRH2 PTGS2
4 fungal esophagitis 10.7 ATP12A ATP4A
5 bladder calculus 10.7 ATP12A ATP4A
6 gastrointestinal neuroendocrine benign tumor 10.7 ATP12A ATP4A
7 neonatal candidiasis 10.7 ATP12A ATP4A
8 squamous papillomatosis 10.7 ATP12A ATP4A
9 acute laryngitis 10.7 ATP12A ATP4A
10 gastroduodenal crohn's disease 10.7 ATP12A ATP4A
11 gastric neuroendocrine neoplasm 10.7 ATP12A ATP4A
12 toxic megacolon 10.7 ATP12A ATP4A
13 postsurgical hypothyroidism 10.7 ATP12A ATP4A
14 gastric antral vascular ectasia 10.6 ATP12A ATP4A
15 esophageal candidiasis 10.6 ATP12A ATP4A
16 rumination disorder 10.6 ATP12A ATP4A
17 granulomatous gastritis 10.6 ATP12A ATP4A
18 laryngeal disease 10.6 ATP12A ATP4A
19 capillary disease 10.6 ATP12A ATP4A
20 duodenal disease 10.6 ATP12A ATP4A
21 dyskinesia of esophagus 10.6 ATP12A ATP4A
22 hernia, hiatus 10.6 ATP12A ATP4A
23 congenital disorder of deglycosylation 10.6 ATP12A ATP4A
24 anismus 10.6 ATP12A ATP4A
25 esophageal atresia/tracheoesophageal fistula 10.6 ATP12A ATP4A
26 laryngeal tuberculosis 10.6 ATP12A ATP4A
27 lymphocytic colitis 10.6 ATP12A ATP4A
28 clostridium difficile colitis 10.6 ATP12A ATP4A
29 aspiration pneumonia 10.6 ATP12A ATP4A
30 diarrhea 1, secretory chloride, congenital 10.6 ATP12A ATP4A
31 chronic intestinal vascular insufficiency 10.6 ATP12A ATP4A
32 eosinophilic gastritis 10.6 ATP12A ATP4A
33 polyposis, skin pigmentation, alopecia, and fingernail changes 10.6 ATP12A ATP4A
34 esophagus adenocarcinoma 10.6 ATP12A ATP4A
35 myopathy, x-linked, with excessive autophagy 10.6 ATP12A ATP4A
36 gastric lymphoma 10.6 ATP12A ATP4A
37 pancreatic steatorrhea 10.6 ATP12A ATP4A
38 pneumatosis cystoides intestinalis 10.6 ATP12A ATP4A
39 superior mesenteric artery syndrome 10.6 ATP12A ATP4A
40 jejunoileitis 10.5 ATP12A ATP4A
41 lateral medullary syndrome 10.5 ATP12A ATP4A
42 paine syndrome 10.5 ATP12A ATP4A
43 esophagitis, eosinophilic, 1 10.5 ATP12A ATP4A
44 cloacal exstrophy 10.5 ATP12A ATP4A
45 functional diarrhea 10.5 ATP12A ATP4A
46 aspiration pneumonitis 10.2 ATP12A ATP4A HRH2
47 peptic esophagitis 10.2 ATP12A ATP4A HRH2
48 laryngitis 10.2 ATP12A ATP4A HRH2
49 chronic laryngitis 10.2 ATP12A ATP4A HRH2
50 photoallergic dermatitis 10.1 ATP12A ATP4A PTGS2

Comorbidity relations with Active Peptic Ulcer Disease via Phenotypic Disease Network (PDN): (show top 50) (show all 147)


Acquired Thrombocytopenia Acute Cystitis
Acute Kidney Failure Acute Myocardial Infarction
Acute Pancreatitis Acute Vascular Insufficiency of Intestine
Alcohol Abuse Alcoholic Gastritis
Alcoholic Hepatitis Alcoholic Liver Cirrhosis
Alzheimer Disease Anus Disease
Aortic Valve Disease 1 Ascending Colon Cancer
Atrophic Gastritis Bacteremia 2
Benign Essential Hypertension Bleeding Disorder, Platelet-Type, 11
Bronchitis Bronchopneumonia
Candidiasis Cardiac Arrest
Cardiogenic Shock Cecal Benign Neoplasm
Cerebral Atherosclerosis Cerebrovascular Disease
Cholestasis Chronic Intestinal Vascular Insufficiency
Chronic Kidney Failure Chronic Myocardial Ischemia
Chronic Pulmonary Heart Disease Chronic Ulcer of Skin
Chylomicron Retention Disease Colon Carcinoma in Situ
Colorectal Cancer Conjunctivitis
Crohn's Disease Cystitis
Decubitus Ulcer Deficiency Anemia
Dermatomycosis Descending Colon Cancer
Disseminated Intravascular Coagulation Duodenitis
Duodenum Cancer Dysthymic Disorder
Encephalopathy Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Esophageal Cancer Esophageal Candidiasis

Graphical network of the top 20 diseases related to Active Peptic Ulcer Disease:



Diseases related to Active Peptic Ulcer Disease
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Symptoms & Phenotypes for Active Peptic Ulcer Disease

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UMLS symptoms related to Active Peptic Ulcer Disease:


abdominal pain, chest pain, constipation, coughing, diarrhea, dyspepsia, edema, fatigue, fever, halitosis, headache, heartburn, hemoptysis, icterus, nausea, nausea and vomiting, pain, pelvic pain, pruritus, sciatica, syncope, vomiting, chronic pain, digestive system symptom, vertigo/dizziness, gastrointestinal gas, blood in stool, symptoms

MGI Mouse Phenotypes related to Active Peptic Ulcer Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.76 VWF ATP12A ATP4A F2 HRH2 PTGS1
2 homeostasis/metabolism MP:0005376 9.56 VWF ATP12A ATP4A F2 HRH2 PTGS1
3 immune system MP:0005387 9.1 SLC9A4 VWF ATP4A F2 PTGS1 PTGS2
Sources

Drugs & Therapeutics for Active Peptic Ulcer Disease

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Drugs for Active Peptic Ulcer Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
2
Ketorolac Approved Phase 3 74103-06-3, 66635-83-4 3826
3
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
4 Peripheral Nervous System Agents Phase 3,Not Applicable
5 Autonomic Agents Phase 3,Not Applicable
6 Dexamethasone acetate Phase 3 1177-87-3
7 Analgesics Phase 3
8 glucocorticoids Phase 3
9
protease inhibitors Phase 3
10 Gastrointestinal Agents Phase 3
11 Cyclooxygenase Inhibitors Phase 3
12 Analgesics, Non-Narcotic Phase 3
13 HIV Protease Inhibitors Phase 3
14 Hormone Antagonists Phase 3
15 Dexamethasone 21-phosphate Phase 3
16 Hormones Phase 3
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
18 Antiemetics Phase 3
19 Ketorolac Tromethamine Phase 3
20 Liver Extracts Phase 3
21 Anti-Inflammatory Agents Phase 3
22 Anti-Inflammatory Agents, Non-Steroidal Phase 3
23 Antirheumatic Agents Phase 3
24 BB 1101 Phase 3
25 Antineoplastic Agents, Hormonal Phase 3
26
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
27
Racepinephrine Approved Not Applicable 329-65-7 838
28 Respiratory System Agents Not Applicable
29 Adrenergic Agents Not Applicable
30 Adrenergic Agonists Not Applicable
31 Adrenergic alpha-Agonists Not Applicable
32 Adrenergic beta-Agonists Not Applicable
33 Mydriatics Not Applicable
34 Coagulants Not Applicable
35 Neurotransmitter Agents Not Applicable
36 Hemostatics Not Applicable
37 Vasoconstrictor Agents Not Applicable
38 Anti-Asthmatic Agents Not Applicable
39 Epinephryl borate Not Applicable
40 Bronchodilator Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Dexamethasone Versus Ketorolac Injection for the Treatment of Local Inflammatory Hand and Upper Extremity Disorders Recruiting NCT02266433 Phase 3 Ketorolac;Dexamethasone
2 Efficacy of Hemostasis by Soft Coagulation Using Endoscopic Hemostatic Forceps for Acute Peptic Ulcer Bleeding Completed NCT02020603 Not Applicable

Search NIH Clinical Center for Active Peptic Ulcer Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :
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Genetic Tests for Active Peptic Ulcer Disease

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Anatomical Context for Active Peptic Ulcer Disease

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MalaCards organs/tissues related to Active Peptic Ulcer Disease:

41
Liver
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Publications for Active Peptic Ulcer Disease

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Articles related to Active Peptic Ulcer Disease:

# Title Authors Year
1
Active peptic ulcer disease in patients with hepatitis C virus-related cirrhosis: the role of Helicobacter pylori infection and portal hypertensive gastropathy. ( 15372116 )
2004
2
Risk of postoperative upper gastrointestinal tract hemorrhage in patients with active peptic ulcer disease undergoing nonulcer surgery. ( 8379806 )
1993
3
Campylobacter pylori is associated with chronic gastritis but not with active peptic ulcer disease. ( 3345253 )
1988
4
Ulcer pain mechanisms. The clinical features of active peptic ulcer disease and implications for therapy. ( 3310199 )
1987
5
Comparison of basal gastric acid and pepsin output in controls vs. active peptic ulcer disease (PUD). ( 358827 )
1978
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Variations for Active Peptic Ulcer Disease

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Expression for Active Peptic Ulcer Disease

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Search GEO for disease gene expression data for Active Peptic Ulcer Disease.
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Pathways for Active Peptic Ulcer Disease

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Pathways related to Active Peptic Ulcer Disease according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Folate Metabolism 1
Show member pathways
 11.97 F2 PTGS1 PTGS2
2
Salivary secretion 37
Show member pathways
 11.65 ATP4A HRH2 SLC9A4
3
Celecoxib Pathway, Pharmacodynamics 61
11.3 PTGS1 PTGS2
4
Regulation of lipolysis in adipocytes 37
11.26 PTGS1 PTGS2
5
Proton Pump Inhibitor Pathway, Pharmacodynamics 61
11.17 ATP4A HRH2
6
Prostaglandin Synthesis and Regulation 1
10.97 PTGS1 PTGS2
7
Ibuprofen Pathway, Pharmacodynamics 61
10.92 PTGS1 PTGS2
8
HETE and HPETE biosynthesis and metabolism 22
Show member pathways
 10.86 PTGS1 PTGS2
9
Eicosanoid Synthesis 1
10.78 PTGS1 PTGS2
10
Prostaglandin 2 biosynthesis and metabolism FM 22
10.73 PTGS1 PTGS2
11
Overview of nanoparticle effects 1
10.6 PTGS1 PTGS2
12
Platelet Aggregation Inhibitor Pathway, Pharmacodynamics 61
10.51 F2 PTGS1 VWF
13
Etoposide Pathway, Pharmacokinetics/Pharmacodynamics 61
10.33 PTGS1 PTGS2
14
Secretion of Hydrochloric Acid in Parietal Cells 1
9.65 ATP4A HRH2
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GO Terms for Active Peptic Ulcer Disease

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Biological processes related to Active Peptic Ulcer Disease according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 hemostasis GO:0007599 9.54 F2 VWF
2 potassium ion import GO:0010107 9.52 ATP12A ATP4A
3 positive regulation of vasoconstriction GO:0045907 9.51 HRH2 PTGS2
4 ATP hydrolysis coupled proton transport GO:0015991 9.49 ATP12A ATP4A
5 prostaglandin metabolic process GO:0006693 9.48 PTGS1 PTGS2
6 regulation of pH GO:0006885 9.46 ATP12A SLC9A4
7 blood coagulation, intrinsic pathway GO:0007597 9.43 F2 VWF
8 cellular sodium ion homeostasis GO:0006883 9.4 ATP12A ATP4A
9 prostaglandin biosynthetic process GO:0001516 9.37 PTGS1 PTGS2
10 sodium ion transport GO:0006814 9.33 ATP12A ATP4A SLC9A4
11 cellular potassium ion homeostasis GO:0030007 9.32 ATP12A ATP4A
12 sodium ion export across plasma membrane GO:0036376 9.26 ATP12A ATP4A
13 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.96 ATP12A ATP4A
14 cyclooxygenase pathway GO:0019371 8.62 PTGS1 PTGS2

Molecular functions related to Active Peptic Ulcer Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxidase activity GO:0004601 9.26 PTGS1 PTGS2
2 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP12A ATP4A
3 potassium:proton exchanging ATPase activity GO:0008900 8.96 ATP12A ATP4A
4 prostaglandin-endoperoxide synthase activity GO:0004666 8.62 PTGS1 PTGS2
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Sources for Active Peptic Ulcer Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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