MCID: ACT170
MIFTS: 16

Acute Ackee Fruit Intoxication

Categories: Rare diseases

Aliases & Classifications for Acute Ackee Fruit Intoxication

MalaCards integrated aliases for Acute Ackee Fruit Intoxication:

Name: Acute Ackee Fruit Intoxication 52 58
Jamaican Vomiting Sickness 52 58
Acute Intoxication by Blighia Sapida 58
Jamaican Vomiting Syndrome 58
Ackee Poisoning 52

Characteristics:

Orphanet epidemiological data:

58
acute ackee fruit intoxication
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;

Classifications:



External Ids:

ICD10 via Orphanet 33 T62.2
UMLS via Orphanet 72 C0274888
Orphanet 58 ORPHA73423

Summaries for Acute Ackee Fruit Intoxication

NIH Rare Diseases : 52 The following summary is from Orphanet , a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 73423 Definition A rare disease caused by the ingestion of unripe Blighia sapida fruits. It is a serious intoxication that is frequent in certain countries in the Caribbean and Western Africa. In contrast, it is rare in France and other Western countries. Intoxication leads to toxic hypoglycaemia and inhibition of neoglucogenesis. The hypoglycaemia is caused by the effect of hypoglycin A, which is found in the arils. Clinical description The clinical manifestations are severe (coma, convulsions, delirium, toxic hepatitis, acute dehydration and a state of shock) and may lead to death. Management and treatment Treatment is symptomatic (administration of glucose, IV or per os ). Prognosis Although the intoxication is generally benign or has a favourable outcome, ingestion of large doses may lead to death: ackee fruit intoxication lead to 29 deaths in 1998 and more than 50 in 2001. Visit the Orphanet disease page for more resources.

MalaCards based summary : Acute Ackee Fruit Intoxication, also known as jamaican vomiting sickness, is related to hypoglycemia and diarrhea. Affiliated tissues include liver and whole blood.

Related Diseases for Acute Ackee Fruit Intoxication

Diseases related to Acute Ackee Fruit Intoxication via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 hypoglycemia 10.4
2 diarrhea 10.3
3 reye syndrome 10.3
4 isovaleric acidemia 10.1
5 ocular motor apraxia 10.1
6 organic acidemia 10.1

Graphical network of the top 20 diseases related to Acute Ackee Fruit Intoxication:



Diseases related to Acute Ackee Fruit Intoxication

Symptoms & Phenotypes for Acute Ackee Fruit Intoxication

Drugs & Therapeutics for Acute Ackee Fruit Intoxication

Search Clinical Trials , NIH Clinical Center for Acute Ackee Fruit Intoxication

Genetic Tests for Acute Ackee Fruit Intoxication

Anatomical Context for Acute Ackee Fruit Intoxication

MalaCards organs/tissues related to Acute Ackee Fruit Intoxication:

40
Liver, Whole Blood

Publications for Acute Ackee Fruit Intoxication

Articles related to Acute Ackee Fruit Intoxication:

(show all 35)
# Title Authors PMID Year
1
Quantification of hypoglycin A and methylenecyclopropylglycine in human plasma by HPLC-MS/MS. 61
30056267 2018
2
Ackee Fruit Poisoning in Eight Siblings: Implications for Public Health Awareness. 61
26324727 2015
3
Quantification of metabolites for assessing human exposure to soapberry toxins hypoglycin A and methylenecyclopropylglycine. 61
26328472 2015
4
A validated method for quantifying hypoglycin A in whole blood by UHPLC-HRMS/MS. 61
25531872 2015
5
Fulminant hepatic failure attributed to ackee fruit ingestion in a patient with sickle cell trait. 61
23259140 2012
6
Akee fruit and Jamaican vomiting sickness (Blighia sapida Köenig). 61
19446675 2009
7
Impact of short- and medium-chain organic acids, acylcarnitines, and acyl-CoAs on mitochondrial energy metabolism. 61
18582432 2008
8
Ackee (Blighia sapida) hypoglycin A toxicity: dose response assessment in laboratory rats. 61
16099087 2006
9
Synthesis of beta-cyclopropylalanines by photolysis of diacyl peroxides. 61
14627411 2003
10
[Neurological syndromes linked with the intake of plants and fungi containing a toxic component (I). Neurotoxic syndromes caused by the ingestion of plants, seeds and fruits]. 61
12717675 2003
11
Metabolic defects caused by treatment with the tetrahydropyridine analog of haloperidol (HPTP), in baboons. 61
9217286 1997
12
The mitochondrial permeability transition: a new pathophysiological mechanism for Reye's syndrome and toxic liver injury. 61
8819478 1996
13
Inhibition of the human methylmalonyl-CoA mutase by various CoA-esters. 61
7989334 1994
14
Jamaican vomiting sickness in Toledo, Ohio. 61
8185109 1994
15
Is serious research possible in the Caribbean? 61
1842551 1991
16
Hypoglycin and Jamaican vomiting sickness. 61
2183231 1990
17
Microvesicular steatosis of the liver. 61
2177300 1990
18
Effect of hypoglycin A on insulin release. 61
3548729 1987
19
Jamaican vomiting sickness: a study of two adult cases. 61
6488562 1984
20
The biogenesis of dicarboxylic acid in rats given hypoglycin. 61
6733131 1984
21
Valproate-induced hepatic injury: analyses of 23 fatal cases. 61
6811394 1982
22
Twin siblings with a Reye's-like syndrome associated with an abnormal organic aciduria, hypoglycemia, diarrhea, and vomiting with close similarities to Jamaican vomiting sickness. 61
7008010 1980
23
Identification of 5-hydroxyhexanoic acid in the urine of twin siblings with a Reye's-like syndrome associated with dicarboxylic aciduria and hypoglycaemia and with similarities to Jamaican vomiting sickness. 61
575058 1979
24
Plasma and urine amino acid changes in rats treated with hypoglycin. 61
699343 1978
25
Dicarboxylic aciduria as an indicator of defective beta-oxidation in twin siblings with a vomiting sickness and hypoglycaemia similar to Jamaican vomiting sickness [proceedings]. 61
640133 1978
26
Identification of 5-hydroxyhexanoic acid in the urine of twin siblings with a syndrome having close similarities to Jamaican vomiting sickness [proceedings]. 61
640132 1978
27
Hypoglycin stimulates insulin secretion. 61
590655 1977
28
Organic acids in Reye's like syndrome: similarities with Jamaican vomiting sickness. 61
68256 1977
29
Jamaican vomiting sickness and Reye's syndrome. 61
995147 1976
30
Identification of n-hexanoylglycine in urines from two patients with Jamaican vomiting sickness. 61
1000831 1976
31
Jamaican vomiting sickness. Biochemical investigation of two cases. 61
940578 1976
32
Jamaican vomiting sickness: a theoretical investigation. 61
968504 1976
33
Production of the features of Reye's syndrome in rats with 4-pentenoic acid. 61
1121419 1975
34
Isovaleric and -methylbutyric acidemias induced by hypoglycin A: mechanism of Jamaican vomiting sickness. 61
5008580 1972
35
Toxic hypoglycaemia (Jamaican vomiting sickness). First case reported from the territory of Trinidad and Tobago. 61
13700023 1960

Variations for Acute Ackee Fruit Intoxication

Expression for Acute Ackee Fruit Intoxication

Search GEO for disease gene expression data for Acute Ackee Fruit Intoxication.

Pathways for Acute Ackee Fruit Intoxication

GO Terms for Acute Ackee Fruit Intoxication

Sources for Acute Ackee Fruit Intoxication

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....