MCID: ACT150
MIFTS: 52

Acute Adrenal Insufficiency

Categories: Endocrine diseases, Rare diseases

Aliases & Classifications for Acute Adrenal Insufficiency

MalaCards integrated aliases for Acute Adrenal Insufficiency:

Name: Acute Adrenal Insufficiency 59 55
Addisonian Crisis 59 73
Acute Adrenocortical Insufficiency 59
Acute Adrenal Failure 59
Adrenocortical Crisis 59
Adrenal Crisis 59

Characteristics:

Orphanet epidemiological data:

59
acute adrenal insufficiency
Inheritance: Autosomal recessive,Not applicable,X-linked dominant; Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 59  
Rare endocrine diseases


Summaries for Acute Adrenal Insufficiency

MalaCards based summary : Acute Adrenal Insufficiency, also known as addisonian crisis, is related to classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency and adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete. An important gene associated with Acute Adrenal Insufficiency is CYP21A2 (Cytochrome P450 Family 21 Subfamily A Member 2), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Cushing syndrome. Affiliated tissues include adrenal gland, skin and pituitary, and related phenotypes are seizures and muscular hypotonia

Wikipedia : 76 Adrenal crisis (also known as Addisonian crisis and acute adrenal insufficiency) is a medical emergency... more...

Related Diseases for Acute Adrenal Insufficiency

Diseases in the Acute Adrenal Insufficiency family:

Secondary Adrenal Insufficiency

Diseases related to Acute Adrenal Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 135)
# Related Disease Score Top Affiliating Genes
1 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 31.7 CYP21A2 POMC
2 adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete 31.7 CYP11A1 CYP21A2 POMC
3 hypoadrenocorticism, familial 31.3 CYP11A1 CYP21A2 POMC
4 adrenocortical carcinoma, hereditary 29.6 CYP11A1 CYP21A2 POMC
5 diabetes insipidus 29.6 POMC REN
6 lipoid congenital adrenal hyperplasia 29.2 CYP11A1 CYP21A2 POMC REN
7 conn's syndrome 29.0 CYP11A1 CYP21A2 POMC REN
8 sheehan syndrome 11.2
9 histoplasmosis 10.2
10 cardiac tamponade 10.1
11 antiphospholipid syndrome 10.1
12 euthyroid sick syndrome 10.1 IL6 POMC
13 pneumonia 10.0
14 pancreas disease 10.0 IL6 POMC
15 hypoaldosteronism 10.0 POMC REN
16 inappropriate adh syndrome 10.0 POMC REN
17 pyelitis 10.0 IL6 REN
18 hyperaldosteronism, familial, type i 10.0 POMC REN
19 familial glucocorticoid deficiency 10.0 POMC REN
20 premenstrual tension 10.0 POMC REN
21 apnea, obstructive sleep 10.0 IL6 REN
22 adrenal cortex disease 10.0 POMC REN
23 mineral metabolism disease 10.0 POMC REN
24 endocrine organ benign neoplasm 10.0 POMC REN
25 pericardial effusion 10.0 IL6 REN
26 chronic fatigue syndrome 10.0 IL6 POMC
27 obstructive jaundice 10.0 IL6 REN
28 hypokalemia 10.0 POMC REN
29 leydig cell tumor 10.0 CYP11A1 CYP21A2
30 intracranial hypertension, idiopathic 10.0
31 autoimmune polyendocrine syndrome, type ii 10.0
32 anorexia nervosa 10.0
33 metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 10.0
34 liver disease 10.0
35 pituitary apoplexy 10.0
36 cholera 10.0
37 candidiasis 10.0
38 pericarditis 10.0
39 orchitis 10.0
40 adrenal cortical adenocarcinoma 10.0
41 pellagra 10.0
42 epididymo-orchitis 10.0
43 hypopituitarism 10.0
44 bilateral massive adrenal hemorrhage 10.0
45 cell type benign neoplasm 10.0 POMC REN
46 overnutrition 10.0 IL6 POMC
47 aortic disease 10.0 IL6 REN
48 iga glomerulonephritis 10.0 IL6 REN
49 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 10.0 CYP11A1 CYP21A2
50 substance dependence 10.0 IL6 POMC

Graphical network of the top 20 diseases related to Acute Adrenal Insufficiency:



Diseases related to Acute Adrenal Insufficiency

Symptoms & Phenotypes for Acute Adrenal Insufficiency

Human phenotypes related to Acute Adrenal Insufficiency:

59 32 (show all 46)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 seizures 59 32 frequent (33%) Frequent (79-30%) HP:0001250
2 muscular hypotonia 59 32 frequent (33%) Frequent (79-30%) HP:0001252
3 muscle weakness 59 32 hallmark (90%) Very frequent (99-80%) HP:0001324
4 failure to thrive 59 32 hallmark (90%) Very frequent (99-80%) HP:0001508
5 nausea and vomiting 59 32 hallmark (90%) Very frequent (99-80%) HP:0002017
6 constipation 59 32 hallmark (90%) Very frequent (99-80%) HP:0002019
7 renal insufficiency 59 32 frequent (33%) Frequent (79-30%) HP:0000083
8 delayed puberty 59 32 occasional (7.5%) Occasional (29-5%) HP:0000823
9 fatigue 59 32 hallmark (90%) Very frequent (99-80%) HP:0012378
10 arthralgia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002829
11 hypoglycemia 59 32 frequent (33%) Frequent (79-30%) HP:0001943
12 hyperuricemia 59 32 frequent (33%) Frequent (79-30%) HP:0002149
13 myocardial infarction 59 32 occasional (7.5%) Occasional (29-5%) HP:0001658
14 abdominal pain 59 32 hallmark (90%) Very frequent (99-80%) HP:0002027
15 weight loss 59 32 hallmark (90%) Very frequent (99-80%) HP:0001824
16 dry skin 59 32 occasional (7.5%) Occasional (29-5%) HP:0000958
17 vitiligo 59 32 occasional (7.5%) Occasional (29-5%) HP:0001045
18 autoimmunity 59 32 hallmark (90%) Very frequent (99-80%) HP:0002960
19 anorexia 59 32 hallmark (90%) Very frequent (99-80%) HP:0002039
20 vertigo 59 32 occasional (7.5%) Occasional (29-5%) HP:0002321
21 hyponatremia 59 32 frequent (33%) Frequent (79-30%) HP:0002902
22 hypercalcemia 59 32 occasional (7.5%) Occasional (29-5%) HP:0003072
23 diarrhea 59 32 hallmark (90%) Very frequent (99-80%) HP:0002014
24 stroke 59 32 occasional (7.5%) Occasional (29-5%) HP:0001297
25 renal salt wasting 59 32 frequent (33%) Frequent (79-30%) HP:0000127
26 adrenal hypoplasia 59 32 occasional (7.5%) Occasional (29-5%) HP:0000835
27 increased circulating renin level 59 32 frequent (33%) Frequent (79-30%) HP:0000848
28 hyperkalemia 59 32 frequent (33%) Frequent (79-30%) HP:0002153
29 increased circulating acth level 59 32 hallmark (90%) Very frequent (99-80%) HP:0003154
30 hypovolemia 59 32 hallmark (90%) Very frequent (99-80%) HP:0011106
31 orthostatic hypotension 59 32 frequent (33%) Frequent (79-30%) HP:0001278
32 hyperpigmentation of the skin 59 32 hallmark (90%) Very frequent (99-80%) HP:0000953
33 normocytic anemia 59 32 frequent (33%) Frequent (79-30%) HP:0001897
34 decreased urinary potassium 59 32 frequent (33%) Frequent (79-30%) HP:0012364
35 sparse axillary hair 59 32 occasional (7.5%) Occasional (29-5%) HP:0002215
36 decreased female libido 59 32 occasional (7.5%) Occasional (29-5%) HP:0030018
37 acute respiratory tract infection 59 32 frequent (33%) Frequent (79-30%) HP:0011948
38 androgen insufficiency 59 32 frequent (33%) Frequent (79-30%) HP:0008226
39 hyperkalemic metabolic acidosis 59 32 frequent (33%) Frequent (79-30%) HP:0005976
40 salt craving 59 32 occasional (7.5%) Occasional (29-5%) HP:0030083
41 hypotension 59 Very frequent (99-80%)
42 primary adrenal insufficiency 59 Obligate (100%)
43 decreased circulating aldosterone level 32 frequent (33%) HP:0004319
44 decreased circulating cortisol level 32 obligate (100%) HP:0008163
45 hypocortisolemia 59 Obligate (100%)
46 hypoaldosteronism 59 Frequent (79-30%)

Drugs & Therapeutics for Acute Adrenal Insufficiency

Search Clinical Trials , NIH Clinical Center for Acute Adrenal Insufficiency

Genetic Tests for Acute Adrenal Insufficiency

Anatomical Context for Acute Adrenal Insufficiency

MalaCards organs/tissues related to Acute Adrenal Insufficiency:

41
Adrenal Gland, Skin, Pituitary, Lung, Spinal Cord, Colon, Kidney

Publications for Acute Adrenal Insufficiency

Articles related to Acute Adrenal Insufficiency:

(show top 50) (show all 168)
# Title Authors Year
1
Acute Adrenal Insufficiency in the Perioperative Period: A Case Report. ( 30020102 )
2018
2
Acute adrenal insufficiency due to adrenal hemorrhage complicating colorectal surgery: Report of two cases and correlation with the antiphospholipid antibody syndrome. ( 30145500 )
2018
3
Addisonian crisis: assessment and management. ( 29528741 )
2018
4
Russell's Viper Envenomation-Associated Addisonian Crisis. ( 30309826 )
2018
5
Refractory collapse and severe burn: Think about acute adrenal insufficiency. ( 29306651 )
2017
6
GroupA 1. Epidemiology of primary and secondary adrenal insufficiency: Prevalence and incidence, acute adrenal insufficiency, long-term morbidity and mortality. ( 29174931 )
2017
7
Group 5: Acute adrenal insufficiency in adults and pediatric patients. ( 29174201 )
2017
8
Fecal impaction as the first manifestation of Addisonian crisis. ( 28267136 )
2017
9
Durable left ventricular assist device as a bridge to recovery for addisonian crisis related cardiomyopathy. ( 28895194 )
2017
10
SOCIETY FOR ENDOCRINOLOGY ENDOCRINE EMERGENCY GUIDANCE: Emergency management of acute adrenal insufficiency (adrenal crisis) in adult patients. ( 27935813 )
2016
11
Acute adrenal insufficiency: an aide-memoire of the critical importance of its recognition and prevention. ( 26968598 )
2016
12
Conduct protocol in emergency: Acute adrenal insufficiency. ( 27992012 )
2016
13
Acute Adrenal Insufficiency Associated with Rathke's Cleft Cyst. ( 26984082 )
2016
14
Acute adrenal insufficiency secondary to bilateral adrenal B-cell lymphoma: a case report and review of the literature. ( 27170834 )
2016
15
An acute adrenal insufficiency revealing pituitary metastases of lung cancer in an elderly patient. ( 27200139 )
2016
16
Histoplasmosis with Addisonian Crisis: Call for Bird Control. ( 26162388 )
2015
17
Addisonian Crisis Due to Antitubercular Therapy. ( 25772943 )
2015
18
Addisonian crisis in a dog treated with phenobarbitone. ( 25817975 )
2015
19
Transient acute adrenal insufficiency associated with adenovirus serotype 40 infection. ( 24928932 )
2014
20
Acute adrenal insufficiency as a first presentation of myelodysplastic syndrome and sigmoid colon adenocarcinoma: a case report. ( 25988040 )
2014
21
Systemic lupus erythematosus presenting as acute adrenal insufficiency: a rare clinical presentation. ( 24669348 )
2014
22
Peri-portal lymphedema in association with an acute adrenal insufficiency: case report. ( 24661563 )
2014
23
Acute adrenal insufficiency following arthroplasty: a case report and review of the literature. ( 24028157 )
2013
24
Idiopathic bilateral adrenal haemorrhage related to acute adrenal insufficiency. ( 23729712 )
2013
25
Rare presentation of shock and acute mesenteric ischaemia secondary to acute adrenal insufficiency in an 11-year-old male. ( 22970910 )
2013
26
Acute adrenal insufficiency due to primary antiphospholipid antibody syndrome. ( 24251172 )
2013
27
A case of Addisonian crisis, acute renal failure, vesiculobullous rash, rhabdomyolysis, neurological disturbances and prolonged viraemia in a patient on long term steroids. ( 23369888 )
2013
28
Addisonian crisis secondary to bilateral adrenal metastases in rectal carcinoma: report of a rare case and literature review. ( 22890387 )
2013
29
Addisonian crisis and severe acidosis in a cat: a case of feline hypoadrenocorticism. ( 23482253 )
2013
30
Acute adrenal insufficiency in cervical spinal cord injury. ( 22120347 )
2012
31
Acute adrenal insufficiency. ( 22712152 )
2012
32
A case of acute adrenal insufficiency unmasked during sunitinib treatment for metastatic renal cell carcinoma. ( 22581915 )
2012
33
Acute adrenal insufficiency in a neonate with bilateral adrenal hemorrhage and combined prothrombotic risk factors. ( 22652827 )
2012
34
Community acquired bilateral upper lobe pneumonia with acute adrenal insufficiency: A new face of Achromobacter Xylosoxidans. ( 23173016 )
2012
35
Acute adrenal insufficiency associated with tuberculous vertebral osteomyelitis and lymphadenopathy: case report. ( 22649455 )
2012
36
A strategy for management of intraoperative Addisonian crisis during coronary artery bypass grafting. ( 22269144 )
2012
37
Acute adrenal insufficiency due to bilateral adrenal hemorrhage. ( 21466057 )
2011
38
Acquired long QT interval in a recurrent septic female patient with polymorphic ventricular tachycardia due to primary acute adrenal insufficiency. ( 21161542 )
2011
39
Addisonian crisis in a young man with atypical anorexia nervosa. ( 21178996 )
2011
40
Manchester United induced addisonian crisis. ( 22174325 )
2011
41
Hypoglycaemic seizure and neonatal acute adrenal insufficiency after maternal exposure to prednisone during pregnancy: a case report. ( 19902248 )
2010
42
Acute adrenal insufficiency may affect outcome in the trauma patient. ( 19385286 )
2009
43
Primary antiphospholipid syndrome presenting as hyponatremic hypertensive syndrome and acute adrenal insufficiency following it: a rare case. ( 19365633 )
2009
44
Evaluation of serum cortisol in the postmortem diagnosis of acute adrenal insufficiency. ( 18520491 )
2008
45
Acute adrenal insufficiency associated with heparin-induced thrombocytopenia. ( 18575053 )
2008
46
Epigastric pain as presentation of an addisonian crisis in a patient with Schmidt syndrome. ( 18272130 )
2008
47
Treatment of acute adrenal insufficiency. ( 17542196 )
2007
48
Acute adrenal insufficiency after a single dose of etomidate. ( 17456730 )
2007
49
Acute reversible cardiomyopathy with cardiogenic shock in a patient with Addisonian crisis: a case report. ( 17079038 )
2007
50
[Acute adrenal insufficiency in the newborn]. ( 16962294 )
2006

Variations for Acute Adrenal Insufficiency

Expression for Acute Adrenal Insufficiency

Search GEO for disease gene expression data for Acute Adrenal Insufficiency.

Pathways for Acute Adrenal Insufficiency

Pathways related to Acute Adrenal Insufficiency according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.11 CYP11A1 CYP21A2 POMC
2
Show member pathways
11.74 CYP11A1 CYP21A2 POMC
3 11.49 IL6 POMC
4
Show member pathways
11.37 CYP11A1 POMC
5 11.28 IL6 POMC
6
Show member pathways
11.14 CYP11A1 CYP21A2
7 11.1 CYP11A1 CYP21A2 POMC
8
Show member pathways
10.74 CYP11A1 CYP21A2 POMC

GO Terms for Acute Adrenal Insufficiency

Biological processes related to Acute Adrenal Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid metabolic process GO:0008202 9.32 CYP11A1 CYP21A2
2 regulation of blood pressure GO:0008217 9.26 POMC REN
3 steroid biosynthetic process GO:0006694 9.16 CYP11A1 CYP21A2
4 sterol metabolic process GO:0016125 8.96 CYP11A1 CYP21A2
5 glucocorticoid biosynthetic process GO:0006704 8.62 CYP11A1 CYP21A2

Molecular functions related to Acute Adrenal Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.16 CYP11A1 CYP21A2
2 iron ion binding GO:0005506 8.96 CYP11A1 CYP21A2
3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 8.62 CYP11A1 CYP21A2

Sources for Acute Adrenal Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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44 MeSH
45 MESH via Orphanet
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49 NCI
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
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74 UMLS via Orphanet
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