Acute Adrenal Insufficiency disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Orphanet: ⁵⁸ A primary adrenal insufficiency caused by a sudden defective production of adrenal steroids (cortisol and aldosterone). It represents an emergency, thus the rapid recognition and prompt therapy are critical for survival even before the diagnosis is made.

MalaCards based summary: Acute Adrenal Insufficiency, also known as addisonian crisis, is related to adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete and hypoadrenocorticism, familial. An important gene associated with Acute Adrenal Insufficiency is CYP21A2 (Cytochrome P450 Family 21 Subfamily A Member 2), and among its related pathways/superpathways are Metapathway biotransformation Phase I and II and Diseases of glycosylation. The drugs Racepinephrine and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, skin and pituitary, and related phenotypes are decreased circulating cortisol level and failure to thrive

Wikipedia: ⁷⁵ Adrenal crisis is a potentially life-threatening medical condition requiring immediate emergency... more...

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Related Diseases for Acute Adrenal Insufficiency

Diseases in the Rare Adrenal Disease family:

Secondary Adrenal Insufficiency	Acute Adrenal Insufficiency
Acquired Chronic Primary Adrenal Insufficiency	Chronic Primary Adrenal Insufficiency
Primary Adrenal Insufficiency

Diseases related to Acute Adrenal Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 313)

#	Related Disease	Score	Top Affiliating Genes
1	adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete	31.3	POMC CYP21A2 CYP11A1
2	hypoadrenocorticism, familial	29.9	POMC CYP21A2 CYP11A1
3	autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia	29.8	CYP21A2 CYP11A1
4	achalasia-addisonianism-alacrima syndrome	29.5	POMC CYP11A1
5	lipoid congenital adrenal hyperplasia	29.5	POMC CYP21A2 CYP11A1
6	conn's syndrome	29.3	POMC CYP21A2 CYP11A1
7	familial glucocorticoid deficiency	29.2	POMC CYP21A2 CYP11A1
8	adrenal hypoplasia, congenital	29.1	POMC CYP21A2 CYP11A1
9	adrenal cortical adenoma	29.1	POMC CYP21A2 CYP11A1
10	adrenal adenoma	29.1	POMC CYP21A2 CYP11A1
11	adrenal cortical carcinoma	29.1	POMC CYP21A2 CYP11A1
12	pseudohermaphroditism	29.0	POMC CYP21A2 CYP11A1
13	premature menopause	28.9	POMC CYP21A2 CYP11A1
14	intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies	11.4
15	waterhouse-friderichsen syndrome	11.3
16	sheehan syndrome	11.2
17	inherited isolated adrenal insufficiency due to partial cyp11a1 deficiency	11.1
18	premature ovarian failure 7	11.1
19	toxic shock syndrome	10.4
20	bilateral massive adrenal hemorrhage	10.4
21	antiphospholipid syndrome	10.4
22	primary adrenal insufficiency	10.3
23	histoplasmosis	10.3
24	autoimmune polyendocrine syndrome, type ii	10.3
25	thrombocytopenia	10.2
26	hypoglycemia	10.2
27	heparin-induced thrombocytopenia	10.2
28	thrombophilia due to thrombin defect	10.1
29	hypothyroidism	10.1
30	hypopituitarism	10.1
31	secondary adrenal insufficiency	10.1
32	lymphoma, hodgkin, classic	10.1
33	cardiac tamponade	10.1
34	autoimmune polyendocrine syndrome	10.1
35	pericarditis	10.1
36	central diabetes insipidus	10.1
37	graves' disease	10.1
38	hypogonadism	10.1
39	diabetes insipidus	10.1
40	broken heart syndrome	10.1
41	autoimmune disease	10.1
42	pituitary hormone deficiency, combined, 2	10.1
43	graves disease 1	10.1
44	cardiac arrest	10.1
45	diarrhea	10.1
46	hyperparathyroidism	10.1
47	adenocarcinoma	10.1
48	hypokalemia	10.1
49	thyroiditis	10.1
50	meningococcemia	10.1

Graphical network of the top 20 diseases related to Acute Adrenal Insufficiency:

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Symptoms & Phenotypes for Acute Adrenal Insufficiency

Human phenotypes related to Acute Adrenal Insufficiency:

³⁰ ⁵⁸ (show all 46)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	decreased circulating cortisol level ³⁰	Obligate (100%)		HP:0008163
2	failure to thrive ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0001508
3	nausea and vomiting ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0002017
4	constipation ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0002019
5	muscle weakness ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0001324
6	fatigue ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0012378
7	autoimmunity ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0002960
8	abdominal pain ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0002027
9	anorexia ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0002039
10	weight loss ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0001824
11	diarrhea ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0002014
12	hyperpigmentation of the skin ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0000953
13	increased circulating acth level ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0003154
14	hypovolemia ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0011106
15	seizure ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001250
16	hypotonia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001252
17	renal insufficiency ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0000083
18	hypoglycemia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001943
19	hyperuricemia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002149
20	hyponatremia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002902
21	hyperkalemia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002153
22	orthostatic hypotension ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001278
23	decreased circulating aldosterone level ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0004319
24	normocytic anemia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001897
25	renal salt wasting ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0000127
26	increased circulating renin level ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0000848
27	decreased urinary potassium ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0012364
28	hyperkalemic metabolic acidosis ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0005976
29	androgen insufficiency ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0008226
30	recurrent acute respiratory tract infection ³⁰	Frequent (33%)		HP:0011948
31	delayed puberty ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000823
32	dry skin ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000958
33	vitiligo ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001045
34	myocardial infarction ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001658
35	vertigo ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002321
36	arthralgia ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002829
37	stroke ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001297
38	hypercalcemia ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0003072
39	sparse axillary hair ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002215
40	adrenal hypoplasia ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000835
41	decreased female libido ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0030018
42	salt craving ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0030083
43	hypotension ⁵⁸		Very frequent (99-80%)
44	primary adrenal insufficiency ⁵⁸		Obligate (100%)
45	hypocortisolemia ⁵⁸		Obligate (100%)
46	acute respiratory tract infection ⁵⁸		Frequent (79-30%)

GenomeRNAi Phenotypes related to Acute Adrenal Insufficiency according to GeneCards Suite gene sharing:

²⁵ (show all 17)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-100	9.9	CYP11A1 CYP21A2
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-105	9.9	CYP21A2
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-11	9.9	CYP11A1
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-120	9.9	CYP11A1
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-139	9.9	CYP21A2
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-145	9.9	CYP21A2
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-161	9.9	CYP21A2
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-166	9.9	CYP11A1
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-184	9.9	CYP11A1 CYP21A2
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-185	9.9	CYP21A2
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-203	9.9	CYP21A2
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-206	9.9	CYP21A2
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-208	9.9	CYP21A2
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-213	9.9	CYP21A2
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-42	9.9	CYP11A1
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-63	9.9	CYP21A2
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-8	9.9	CYP21A2

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Drugs & Therapeutics for Acute Adrenal Insufficiency

Drugs for Acute Adrenal Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Racepinephrine

Approved, Vet_approved

Phase 4

51-43-4, 329-65-7

838 5816

2

Prednisolone phosphate

Approved, Vet_approved

Phase 4

302-25-0

3

Prednisolone acetate

Approved, Vet_approved

Phase 4

52-21-1

4

Prednisolone

Approved, Vet_approved

Phase 4

50-24-8

4894 5755

5

Prednisone

Approved, Vet_approved

Phase 4

53-03-2

5865

6

Methylprednisolone hemisuccinate

Approved

Phase 4

2921-57-5

1875

7

Methylprednisolone

Approved, Vet_approved

Phase 4

83-43-2

4159 6741

8

Hydrocortisone succinate

Approved

Phase 4

2203-97-6

3643

9

Hydrocortisone acetate

Approved, Vet_approved

Phase 4

50-03-3

10

Hydrocortisone

Approved, Vet_approved

Phase 4

50-23-7

3640 5754

11

Prednisolone hemisuccinate

Experimental

Phase 4

2920-86-7

4897

12

Epinephryl borate

Phase 4

13

Antineoplastic Agents, Hormonal

Phase 4

14

Neuroprotective Agents

Phase 4

15

Hormones

Phase 4

16

Hormone Antagonists

Phase 4

17

Vasoconstrictor Agents

Phase 4

18

Antiemetics

Phase 4

19

glucocorticoids

Phase 4

20

Anti-Inflammatory Agents

Phase 4

21

Methylprednisolone Acetate

Phase 4

584547

22

Gastrointestinal Agents

Phase 4

23

Hydrocortisone-17-butyrate

Phase 4

24

Hydrocortisone 17-butyrate 21-propionate

Phase 4

25

Protective Agents

Phase 4

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	An Open-label, Prospective, Randomized, Controlled Clinical Trial of the Use of Reduced Duration Versus Standard Duration Steroid Replacement Therapy for Acute Adrenal Insufficiency in Patients With Septic Shock	Terminated	NCT00842933	Phase 4	Corticosteroid
2	Vaginal Prednisone Administration for Prevention of Adrenal Crisis - a Bioequivalence Study	Completed	NCT02689960	Phase 2	100mg prednisone suppository
3	Predisposing Factors for the Incidence of Adrenal Crisis in Chronic Adrenal Insufficiency	Unknown status	NCT03410160
4	Prospective Study to Investigate Adrenal Crisis in Patients With Chronic Adrenal Insufficiency (Six-year Follow-up)	Completed	NCT03499990
5	Prospective Cohort-study on the Incidence of Adrenal Crisis in Patients With Chronic Adrenal Insufficiency	Completed	NCT01184209
6	Novel Treatment of Adrenal Crisis: an Early Clinical Trial With Nebulized Prednisolone	Recruiting	NCT05639127	Early Phase 1	Prednisolone

Search NIH Clinical Center for Acute Adrenal Insufficiency

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Genetic Tests for Acute Adrenal Insufficiency

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Anatomical Context for Acute Adrenal Insufficiency

Organs/tissues related to Acute Adrenal Insufficiency:

MalaCards : Adrenal Gland, Skin, Pituitary, Adrenal Cortex, Spinal Cord, Cortex, Lung

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Publications for Acute Adrenal Insufficiency

Articles related to Acute Adrenal Insufficiency:

(show top 50) (show all 1530)

#	Title	Authors	PMID	Year
1	Hypopituitarism. ⁵³ ⁶²	Ascoli P...Cavagnini F	17077946	2006
2	Congenital adrenal hyperplasia. ⁵³ ⁶²	Spandri A...Beccaria L	15568308	2004
3	The Assessment of the Hypothalamic-Pituitary-Adrenal Axis After Oncological Treatment in Pediatric Patients with Acute Lymphoblastic Leukemia ⁶²	Hull B...Starzyk JB	35633644	2022
4	Approach to the Patient with Adrenal Hemorrhage. ⁶²	Elhassan YS...Baldeweg SE	36404284	2022
5	Intracardiac thrombosis following intravenous zoledronate treatment in a child with steroid-induced osteoporosis. ⁶²	Case SJ...Davies JH	36427218	2022
6	End-of-life impact of concurrent diabetes mellitus and adrenal insufficiency as immune-related adverse events in an advanced non-small cell lung cancer patient. ⁶²	Nakamura T...Ohe Y	36195556	2022
7	The management of congenital adrenal hyperplasia during preconception, pregnancy, and postpartum. ⁶²	Maher JY...Merke DP	36399318	2022
8	Acute adrenal insufficiency in a patient with panhypopituitarism after vaccination against COVID-19 (BNT162b2 Pfizer-BioNTech). ⁶²	Gonzalez Lopez J...Riestra Fernandez M	36428206	2022
9	[Acute adrenal insufficiency in a patient with panhypopituitarism after vaccination against COVID-19 (BNT162b2 Pfizer-Biontech)]. ⁶²	Gonzalez Lopez J...Riestra Fernandez M	34957378	2022
10	Effect of long-term management of hypoadrenocorticism on the quality of life of affected dogs and their owners. ⁶²	Hupfeld J...Rieder J	35941756	2022
11	Doctors, teach your adrenal insufficiency patients well: provide them with a European Emergency Card! ⁶²	Beun JG...Dahlqvist P	36327148	2022
12	Congenital adrenal hyperplasia in patients with adrenal tumors: a population-based case-control study. ⁶²	Sahlander F...Falhammar H	36269558	2022
13	Glucocorticoid receptor blockers. ⁶²	Molitch ME	35507245	2022
14	Prevalence and risk factors for hypothalamus-pituitary-adrenal axis suppression in infants receiving glucocorticoid eye drops after ocular surgery. ⁶²	Schmidt DC...Bangsgaard R	36165330	2022
15	Emphasizing Pulmonary Function With Respiratory Therapy in an Infant With Congenital Adrenal Hyperplasia, Bronchopneumonia and Leptomeningitis. ⁶²	Jaiswal PR...Vardhan V	36199651	2022
16	Congenital lipoid adrenal hyperplasia with Graves' disease: A case report. ⁶²	Wang YJ...Wang FT	36159444	2022
17	Congenital lipoid adrenal hyperplasia in a Saudi infant. ⁶²	Subki SH...Al-Agha AE	36053179	2022
18	Central hypothyroidism with myxoedema: a less known but clinically challenging presentation. ⁶²	Kaur K...Sridharan K	36100285	2022
19	Delayed diagnosis of complex glycerol kinase deficiency in a Chinese male infant: a case report. ⁶²	Tao N...Su Y	36050749	2022
20	Chinese primary adrenal lymphoma complicated with adrenal crisis: A case report and literature review. ⁶²	Zhang Y...Zhang Q	36204896	2022
21	Adult height of children with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. ⁶²	Tsai MM...Tung YC	36155706	2022
22	Survey of glucocorticoid dose escalation in patients with adrenal insufficiency during the peri-COVID-19 vaccination period. ⁶²	Bando H...Ogawa W	36104247	2022
23	[Acute adrenal insufficiency: an entity that should not be missed]. ⁶²	Ducor L...Rouiller N	36082384	2022
24	Adrenal insufficiency among children treated with hormonal therapy for infantile spasms. ⁶²	Dore-Brabant G...Chrestian N	35759339	2022
25	Diagnosis and Management of Adrenal Insufficiency and Adrenal Crisis in the Emergency Department. ⁶²	Lentz S...Long B	36038436	2022
26	Serological Evidence and Self-reported Outcomes in Patients with Adrenal Insufficiency during the first waves of COVID-19 in the North-East Italy. ⁶²	Sabbadin C...Ceccato F	35959624	2022
27	Case of Junctional Rhythm in the Setting of Acute Adrenal Insufficiency. ⁶²	Patel P...Kelschenbach K	36059370	2022
28	Adrenal Gland Function and Dysfunction During COVID-19. ⁶²	Kanczkowski W...Bornstein SR	35944524	2022
29	Hypothalamic-pituitary-adrenal axis recovery after treatment of Cushing's syndrome. ⁶²	Balasko A...Dusek T	35726348	2022
30	Adrenal Crisis Mimicking COVID-19 Encephalopathy in a Teenager with Craniopharyngioma. ⁶²	Chien TC...Liu YL	36010128	2022
31	Pallister-Hall syndrome diagnosed in a young man after an acute adrenal crisis. ⁶²	Grassa A...Chihaoui M	36017114	2022
32	Management of patients at risk of adrenal crisis in the dental setting: a review of current practice in UK dental teaching hospitals. ⁶²	Gaw AG...Goodall CA	35931749	2022
33	The ISAQ Score Does Not Predict Adrenal Crisis in Patients with Primary Adrenal Insufficiency. ⁶²	Quinkler M...Kienitz T	35240692	2022
34	Devastating salt-wasting crisis in a four-month-old male child with congenital adrenal hyperplasia, highlighting the essence of neonatal screening. ⁶²	Reddy NA...Maskey U	35846927	2022
35	Isolated ACTH deficiency following immunization with the BNT162b2 SARS-CoV-2 vaccine: a case report. ⁶²	Morita S...Matsuoka TA	35854260	2022
36	Adrenal insufficiency. ⁶²	Kumar R...Wassif WS	35534201	2022
37	Adrenal Crisis Presenting as Recurrent Encephalopathy Mimicking Autoimmune, Infectious Encephalitis, and Common Variable Immune Deficiency: A Case Report. ⁶²	Poon JT...Paz Soldan MM	34855666	2022
38	Adrenal Crisis Secondary to COVID-19 Vaccination in a Patient With Hypopituitarism. ⁶²	Markovic N...Nambi S	35496468	2022
39	Adrenal insufficiency in pregnancy: Physiology, diagnosis, management and areas for future research. ⁶²	Lee JH...Torpy DJ	35816262	2022
40	Interventions for the prevention of adrenal crisis in adults with primary adrenal insufficiency: a systematic review. ⁶²	Shepherd LM...Carrick-Sen DM	35536876	2022
41	Critical Illness-induced Corticosteroid Insufficiency: What It Is Not and What It Could Be. ⁶²	Teblick A...Van den Berghe G	35358303	2022
42	Postoperative adrenal insufficiency in Conn's syndrome-does it occur frequently? ⁶²	Zelinka T...Widimsky J	34615973	2022
43	Approach to the Patient With Glucocorticoid-induced Adrenal Insufficiency. ⁶²	Borresen SW...Feldt-Rasmussen U	35302603	2022
44	Antibody and T cell responses to COVID-19 vaccination in patients receiving anticancer therapies. ⁶²	Rouhani SJ...Gajewski TF	35732350	2022
45	Adrenal crises in adolescents and young adults. ⁶²	Rushworth RL...Falhammar H	35583847	2022
46	A Novel SCNN1A Variation in a Patient with Autosomal-recessive Pseudohypoaldosteronism Type 1 ⁶²	Huneif MA...AlSaheel A	33829730	2022
47	Factors influencing the levothyroxine dose in the hormone replacement therapy of primary hypothyroidism in adults. ⁶²	Caron P...Duntas L	34671932	2022
48	Atypical Case of Schmidt's Syndrome in a Young Male. ⁶²	Abdullah I...Camferdam RR	35911265	2022
49	Regarding "Fatal adrenal crisis due to Addison's disease arising in the context of autoimmune polyglandular syndrome type 1". ⁶²	De-Giorgio F...Vetrugno G	34851495	2022
50	Author Correction: Regarding "Fatal adrenal crisis due to Addison's disease arising in the context of autoimmune polyglandular syndrome type 1". ⁶²	De-Giorgio F...Vetrugno G	35275325	2022

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Genes for Acute Adrenal Insufficiency

Genes related to Acute Adrenal Insufficiency (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	CYP21A2	Cytochrome P450 Family 21 Subfamily A Member 2	Protein Coding	8.26	Novoseek inferred ⁵³	15568308
2	CYP11A1	Cytochrome P450 Family 11 Subfamily A Member 1	Protein Coding	7.69	GeneCards inferred via : Disorders (show sections)
3	POMC	Proopiomelanocortin	Protein Coding	7.25	Novoseek inferred ⁵³	17077946

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Variations for Acute Adrenal Insufficiency

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Expression for Acute Adrenal Insufficiency

Search GEO for disease gene expression data for Acute Adrenal Insufficiency.

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Pathways for Acute Adrenal Insufficiency

Pathways related to Acute Adrenal Insufficiency according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Metapathway biotransformation Phase I and II ⁷⁴ Show member pathways Acetaminophen metabolism ²² Aflatoxin B1 metabolism ⁷⁴ Artemisinin and Derivatives Pathway, Pharmacokinetics ⁶⁰ Arylamine metabolism ⁷⁴ Benzo(a)pyrene metabolism ⁷⁴ Benzo[a]pyrene metabolism ²² Benzodiazepine Pathway, Pharmacokinetics ⁶⁰ Biological oxidations ⁶⁶ Cannabidiol Pathway, Pharmacokinetics ⁶⁰ Doxepin Pathway, Pharmacokinetics ⁶⁰ Estradiol metabolism ²² Flurbiprofen Pathway, Pharmacokinetics ⁶⁰ Haloperidol Pathway, Pharmacokinetics ⁶⁰ Methylation ⁶⁶ Naproxen Pathway, Pharmacokinetics ⁶⁰ Phase II - Conjugation of compounds ⁶⁶ Phenprocoumon Pathway, Pharmacokinetics ⁶⁰ Sorafenib Pharmacokinetics ⁶⁰ Tamoxifen Pathway, Pharmacokinetics ⁶⁰ Voriconazole Pathway, Pharmacokinetics ⁶⁰	12.42	POMC CYP21A2 CYP11A1
2	Diseases of glycosylation ⁶⁶ Show member pathways Defective ALG1 causes CDG-1k ⁶⁶ Defective ALG11 causes CDG-1p ⁶⁶ Defective ALG12 causes CDG-1g ⁶⁶ Defective ALG14 causes ALG14-CMS ⁶⁶ Defective ALG2 causes CDG-1i ⁶⁶ Defective ALG3 causes CDG-1d ⁶⁶ Defective ALG6 causes CDG-1c ⁶⁶ Defective ALG8 causes CDG-1h ⁶⁶ Defective ALG9 causes CDG-1l ⁶⁶ Defective DPAGT1 causes CDG-1j, CMSTA2 ⁶⁶ Defective GNE causes sialuria, NK and IBM2 ⁶⁶ Defective MPDU1 causes CDG-1f ⁶⁶ Defective NEU1 causes sialidosis ⁶⁶ Defective RFT1 causes CDG-1n ⁶⁶ Diseases associated with glycosylation precursor biosynthesis ⁶⁶ Diseases associated with N-glycosylation of proteins ⁶⁶ Diseases of metabolism ⁶⁶ MPS IV - Morquio syndrome B ⁶⁶	12.15	POMC CYP21A2 CYP11A1
3	Oxidation by cytochrome P450 ⁷⁴ Show member pathways Amine Oxidase reactions ⁶⁶ Aryl hydrocarbon receptor signalling ⁶⁶ Atomoxetine Pathway, Pharmacokinetics ⁶⁰ Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB ⁶⁶ Celecoxib Pathway, Pharmacokinetics ⁶⁰ Cyclophosphamide Pathway, Pharmacokinetics ⁶⁰ CYP2E1 reactions ⁶⁶ Cytochrome P450 - arranged by substrate type ⁶⁶ Defective CYP24A1 causes HCAI ⁶⁶ Defective CYP26B1 causes RHFCA ⁶⁶ Defective CYP26C1 causes FFDD4 ⁶⁶ Defective CYP27A1 causes CTX ⁶⁶ Defective CYP27B1 causes VDDR1A ⁶⁶ Defective CYP27B1 causes VDDR1B ⁶⁶ Defective CYP4F22 causes ARCI5 ⁶⁶ Defective MAOA causes BRUNS ⁶⁶ Eicosanoids ⁶⁶ Endogenous sterols ⁶⁶ Ethanol oxidation ⁶⁶ Fatty acid omega-oxidation ⁷⁴ Fatty acids ⁶⁶ Fluvoxamine Pathway, Pharmacokinetics ⁶⁰ Lidocaine Pathway, Pharmacokinetics ⁶⁰ Miscellaneous substrates ⁶⁶ Phase I - Functionalization of compounds ⁶⁶ Prasugrel Pathway, Pharmacokinetics ⁶⁰ Sterols are 12-hydroxylated by CYP8B1 ⁶⁶ Vitamin D2 (ergocalciferol) metabolism ²² Vitamins ⁶⁶ Xenobiotics ⁶⁶	12.07	POMC CYP21A2 CYP11A1
4	Metabolism of steroids ⁶⁶ Show member pathways Activation of gene expression by SREBF (SREBP) ⁶⁶ allopregnanolone biosynthesis ⁶¹ androgen biosynthesis ⁶¹ Cholesterol synthesis disorders ⁷⁴ Defective CYP17A1 causes AH5 ⁶⁶ Regulation of cholesterol biosynthesis by SREBP (SREBF) ⁶⁶ Sterol regulatory element-binding proteins (SREBP) signaling ⁷⁴ Vitamin D (calciferol) metabolism ⁶⁶	11.89	POMC CYP21A2 CYP11A1
5	Metabolism of steroid hormones ⁶⁶ Show member pathways Androgen biosynthesis ⁶⁶ Defective CYP11A1 causes AICSR ⁶⁶ Defective CYP11B1 causes AH4 ⁶⁶ Defective CYP21A2 causes AH3 ⁶⁶ Electron transport from NADPH to Ferredoxin ⁶⁶ Estrogen biosynthesis ⁶⁶ Glucocorticoid and Mineralcorticoid Metabolism ⁷⁴ Glucocorticoid biosynthesis ⁶⁶ Mineralocorticoid biosynthesis ⁶⁶ Pregnenolone biosynthesis ⁶⁶	11.12	POMC CYP21A2 CYP11A1
6	Metabolic disorders of biological oxidation enzymes ⁶⁶	10.9	CYP21A2 CYP11A1
7	Corticotropin-releasing hormone signaling pathway ⁷⁴	10.76	POMC CYP21A2 CYP11A1

Sources

GO Terms for Acute Adrenal Insufficiency

Biological processes related to Acute Adrenal Insufficiency according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	steroid metabolic process	GO:0008202	9.43	CYP21A2 CYP11A1
2	steroid biosynthetic process	GO:0006694	9.33	CYP21A2 CYP11A1
3	sterol metabolic process	GO:0016125	9.26	CYP21A2 CYP11A1
4	glucocorticoid biosynthetic process	GO:0006704	8.92	CYP21A2 CYP11A1

Molecular functions related to Acute Adrenal Insufficiency according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	heme binding	GO:0020037	9.56	CYP21A2 CYP11A1
2	iron ion binding	GO:0005506	9.46	CYP21A2 CYP11A1
3	monooxygenase activity	GO:0004497	8.96	CYP21A2 CYP11A1
4	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0016705	8.62	CYP21A2 CYP11A1

Sources

Sources for Acute Adrenal Insufficiency

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: ACT150 MIFTS: 47	Acute Adrenal Insufficiency Categories: Endocrine diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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Acute Adrenal Insufficiency

Aliases & Classifications for Acute Adrenal Insufficiency

MalaCards integrated aliases for Acute Adrenal Insufficiency:

Characteristics:

Inheritance:

Age Of Onset:

Classifications:

External Ids:

Summaries for Acute Adrenal Insufficiency

Related Diseases for Acute Adrenal Insufficiency

Diseases in the Rare Adrenal Disease family:

Diseases related to Acute Adrenal Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Acute Adrenal Insufficiency:

Symptoms & Phenotypes for Acute Adrenal Insufficiency

Human phenotypes related to Acute Adrenal Insufficiency:

GenomeRNAi Phenotypes related to Acute Adrenal Insufficiency according to GeneCards Suite gene sharing:

Drugs & Therapeutics for Acute Adrenal Insufficiency

Drugs for Acute Adrenal Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Genetic Tests for Acute Adrenal Insufficiency

Anatomical Context for Acute Adrenal Insufficiency

Organs/tissues related to Acute Adrenal Insufficiency:

Publications for Acute Adrenal Insufficiency

Articles related to Acute Adrenal Insufficiency:

Genes for Acute Adrenal Insufficiency

Genes related to Acute Adrenal Insufficiency (0 elite genes):

Variations for Acute Adrenal Insufficiency

Expression for Acute Adrenal Insufficiency

Pathways for Acute Adrenal Insufficiency

Pathways related to Acute Adrenal Insufficiency according to GeneCards Suite gene sharing:

GO Terms for Acute Adrenal Insufficiency

Biological processes related to Acute Adrenal Insufficiency according to GeneCards Suite gene sharing:

Molecular functions related to Acute Adrenal Insufficiency according to GeneCards Suite gene sharing:

Sources for Acute Adrenal Insufficiency