MCID: ACT150
MIFTS: 44

Acute Adrenal Insufficiency

Categories: Endocrine diseases, Rare diseases

Aliases & Classifications for Acute Adrenal Insufficiency

MalaCards integrated aliases for Acute Adrenal Insufficiency:

Name: Acute Adrenal Insufficiency 60 56
Addisonian Crisis 60 74
Acute Adrenocortical Insufficiency 60
Acute Adrenal Failure 60
Adrenocortical Crisis 60
Adrenal Crisis 60

Characteristics:

Orphanet epidemiological data:

60
acute adrenal insufficiency
Inheritance: Autosomal recessive,Not applicable,X-linked dominant; Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 60  
Rare endocrine diseases


Summaries for Acute Adrenal Insufficiency

MalaCards based summary : Acute Adrenal Insufficiency, also known as addisonian crisis, is related to classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency and adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete. An important gene associated with Acute Adrenal Insufficiency is CYP21A2 (Cytochrome P450 Family 21 Subfamily A Member 2), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Interleukin-4 and 13 signaling. Affiliated tissues include adrenal gland, skin and pituitary, and related phenotypes are decreased circulating cortisol level and muscle weakness

Wikipedia : 77 Adrenal crisis is a medical emergency and potentially life-threatening situation requiring immediate... more...

Related Diseases for Acute Adrenal Insufficiency

Diseases in the Acute Adrenal Insufficiency family:

Secondary Adrenal Insufficiency

Diseases related to Acute Adrenal Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 151)
# Related Disease Score Top Affiliating Genes
1 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 31.7 CYP21A2 POMC
2 adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete 31.6 CYP11A1 CYP21A2 POMC
3 hypoadrenocorticism, familial 31.2 CYP11A1 CYP21A2 POMC
4 diabetes insipidus 29.7 POMC REN
5 adrenocortical carcinoma, hereditary 29.5 CYP11A1 CYP21A2 POMC
6 adrenal cortical adenoma 29.1 CYP11A1 CYP21A2 POMC
7 lipoid congenital adrenal hyperplasia 28.8 CYP11A1 CYP21A2 POMC REN
8 conn's syndrome 28.8 CYP11A1 CYP21A2 POMC REN
9 sheehan syndrome 11.2
10 premature ovarian failure 7 10.3
11 histoplasmosis 10.2
12 antiphospholipid syndrome 10.2
13 cardiac tamponade 10.2
14 bilateral massive adrenal hemorrhage 10.1
15 hypoaldosteronism 10.1 POMC REN
16 inappropriate adh syndrome 10.1 POMC REN
17 familial glucocorticoid deficiency 10.1 POMC REN
18 hyperaldosteronism, familial, type i 10.1 POMC REN
19 premenstrual tension 10.1 POMC REN
20 adrenal cortex disease 10.1 POMC REN
21 ocular motor apraxia 10.1
22 mineral metabolism disease 10.1 POMC REN
23 endocrine organ benign neoplasm 10.1 POMC REN
24 pneumonia 10.0
25 hypokalemia 10.0 POMC REN
26 cell type benign neoplasm 10.0 POMC REN
27 euthyroid sick syndrome 10.0 IL6 POMC
28 pyelitis 10.0 IL6 REN
29 apnea, obstructive sleep 10.0 IL6 REN
30 intracranial hypertension, idiopathic 10.0
31 autoimmune polyendocrine syndrome, type ii 10.0
32 anorexia nervosa 10.0
33 adrenal cortical carcinoma 10.0
34 liver disease 10.0
35 pituitary apoplexy 10.0
36 cholera 10.0
37 candidiasis 10.0
38 pericarditis 10.0
39 orchitis 10.0
40 adrenal cortical adenocarcinoma 10.0
41 pellagra 10.0
42 epididymo-orchitis 10.0
43 hypopituitarism 10.0
44 pericardial effusion 10.0 IL6 REN
45 obstructive jaundice 10.0 IL6 REN
46 pancreas disease 10.0 IL6 POMC
47 leydig cell tumor 10.0 CYP11A1 CYP21A2
48 lung cancer 10.0
49 burns 10.0
50 spinal cord injury 10.0

Graphical network of the top 20 diseases related to Acute Adrenal Insufficiency:



Diseases related to Acute Adrenal Insufficiency

Symptoms & Phenotypes for Acute Adrenal Insufficiency

Human phenotypes related to Acute Adrenal Insufficiency:

33 60 (show all 47)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 decreased circulating cortisol level 33 obligate (100%) HP:0008163
2 muscle weakness 60 33 hallmark (90%) Very frequent (99-80%) HP:0001324
3 failure to thrive 60 33 hallmark (90%) Very frequent (99-80%) HP:0001508
4 nausea and vomiting 60 33 hallmark (90%) Very frequent (99-80%) HP:0002017
5 constipation 60 33 hallmark (90%) Very frequent (99-80%) HP:0002019
6 fatigue 60 33 hallmark (90%) Very frequent (99-80%) HP:0012378
7 abdominal pain 60 33 hallmark (90%) Very frequent (99-80%) HP:0002027
8 weight loss 60 33 hallmark (90%) Very frequent (99-80%) HP:0001824
9 autoimmunity 60 33 hallmark (90%) Very frequent (99-80%) HP:0002960
10 anorexia 60 33 hallmark (90%) Very frequent (99-80%) HP:0002039
11 diarrhea 60 33 hallmark (90%) Very frequent (99-80%) HP:0002014
12 increased circulating acth level 60 33 hallmark (90%) Very frequent (99-80%) HP:0003154
13 hypovolemia 60 33 hallmark (90%) Very frequent (99-80%) HP:0011106
14 hyperpigmentation of the skin 60 33 hallmark (90%) Very frequent (99-80%) HP:0000953
15 seizures 60 33 frequent (33%) Frequent (79-30%) HP:0001250
16 muscular hypotonia 60 33 frequent (33%) Frequent (79-30%) HP:0001252
17 renal insufficiency 60 33 frequent (33%) Frequent (79-30%) HP:0000083
18 hypoglycemia 60 33 frequent (33%) Frequent (79-30%) HP:0001943
19 hyperuricemia 60 33 frequent (33%) Frequent (79-30%) HP:0002149
20 hyponatremia 60 33 frequent (33%) Frequent (79-30%) HP:0002902
21 renal salt wasting 60 33 frequent (33%) Frequent (79-30%) HP:0000127
22 increased circulating renin level 60 33 frequent (33%) Frequent (79-30%) HP:0000848
23 hyperkalemia 60 33 frequent (33%) Frequent (79-30%) HP:0002153
24 orthostatic hypotension 60 33 frequent (33%) Frequent (79-30%) HP:0001278
25 normocytic anemia 60 33 frequent (33%) Frequent (79-30%) HP:0001897
26 decreased urinary potassium 60 33 frequent (33%) Frequent (79-30%) HP:0012364
27 androgen insufficiency 60 33 frequent (33%) Frequent (79-30%) HP:0008226
28 hyperkalemic metabolic acidosis 60 33 frequent (33%) Frequent (79-30%) HP:0005976
29 decreased circulating aldosterone level 33 frequent (33%) HP:0004319
30 recurrent acute respiratory tract infection 33 frequent (33%) HP:0011948
31 delayed puberty 60 33 occasional (7.5%) Occasional (29-5%) HP:0000823
32 arthralgia 60 33 occasional (7.5%) Occasional (29-5%) HP:0002829
33 myocardial infarction 60 33 occasional (7.5%) Occasional (29-5%) HP:0001658
34 dry skin 60 33 occasional (7.5%) Occasional (29-5%) HP:0000958
35 vitiligo 60 33 occasional (7.5%) Occasional (29-5%) HP:0001045
36 vertigo 60 33 occasional (7.5%) Occasional (29-5%) HP:0002321
37 hypercalcemia 60 33 occasional (7.5%) Occasional (29-5%) HP:0003072
38 stroke 60 33 occasional (7.5%) Occasional (29-5%) HP:0001297
39 adrenal hypoplasia 60 33 occasional (7.5%) Occasional (29-5%) HP:0000835
40 sparse axillary hair 60 33 occasional (7.5%) Occasional (29-5%) HP:0002215
41 salt craving 60 33 occasional (7.5%) Occasional (29-5%) HP:0030083
42 decreased female libido 60 33 occasional (7.5%) Occasional (29-5%) HP:0030018
43 hypotension 60 Very frequent (99-80%)
44 primary adrenal insufficiency 60 Obligate (100%)
45 hypocortisolemia 60 Obligate (100%)
46 hypoaldosteronism 60 Frequent (79-30%)
47 acute respiratory tract infection 60 Frequent (79-30%)

Drugs & Therapeutics for Acute Adrenal Insufficiency

Search Clinical Trials , NIH Clinical Center for Acute Adrenal Insufficiency

Genetic Tests for Acute Adrenal Insufficiency

Anatomical Context for Acute Adrenal Insufficiency

MalaCards organs/tissues related to Acute Adrenal Insufficiency:

42
Adrenal Gland, Skin, Pituitary, Liver, Lung, Spinal Cord, Thyroid

Publications for Acute Adrenal Insufficiency

Articles related to Acute Adrenal Insufficiency:

(show top 50) (show all 183)
# Title Authors Year
1
Acute Adrenal Insufficiency in the Perioperative Period: A Case Report. ( 30020102 )
2019
2
Acute Adrenal Insufficiency After an Antiemetic Dose of Dexamethasone: A Case Report. ( 30633007 )
2019
3
Bilateral adrenal myelolipomas presenting as acute adrenal insufficiency in an adult with congenital adrenal hyperplasia. ( 30739087 )
2019
4
Acute Adrenal Insufficiency Precipitated by the Discontinuation of a Betamethasone and Dextrochlorpheniramine Combination: The Diagnostic Utility of an Echocardiographic Assessment of Systemic Vascular Resistance. ( 30996179 )
2019
5
SEEN guidelines for the management and prevention of acute adrenal insufficiency. ( 31003863 )
2019
6
Frequent and prolonged administration of glucocorticoid for acute adrenal insufficiency treatment can cause diabetes mellitus: A case of holoprosencephaly. ( 31037021 )
2019
7
Refractory collapse and severe burn: Think about acute adrenal insufficiency. ( 29306651 )
2018
8
Acute adrenal insufficiency due to adrenal hemorrhage complicating colorectal surgery: Report of two cases and correlation with the antiphospholipid antibody syndrome. ( 30145500 )
2018
9
Hypotensive presentation of cardiac tamponade can simulate Addisonian crisis. ( 29894241 )
2018
10
Addisonian crisis: assessment and management. ( 29528741 )
2018
11
Russell's Viper Envenomation-Associated Addisonian Crisis. ( 30309826 )
2018
12
Group 5: Acute adrenal insufficiency in adults and pediatric patients. ( 29174201 )
2017
13
Group 1. Epidemiology of primary and secondary adrenal insufficiency: Prevalence and incidence, acute adrenal insufficiency, long-term morbidity and mortality. ( 29174931 )
2017
14
Fecal impaction as the first manifestation of Addisonian crisis. ( 28267136 )
2017
15
Durable left ventricular assist device as a bridge to recovery for addisonian crisis related cardiomyopathy. ( 28895194 )
2017
16
Acute adrenal insufficiency: an aide-memoire of the critical importance of its recognition and prevention. ( 26968598 )
2016
17
Acute Adrenal Insufficiency Associated with Rathke's Cleft Cyst. ( 26984082 )
2016
18
Acute adrenal insufficiency secondary to bilateral adrenal B-cell lymphoma: a case report and review of the literature. ( 27170834 )
2016
19
An acute adrenal insufficiency revealing pituitary metastases of lung cancer in an elderly patient. ( 27200139 )
2016
20
SOCIETY FOR ENDOCRINOLOGY ENDOCRINE EMERGENCY GUIDANCE: Emergency management of acute adrenal insufficiency (adrenal crisis) in adult patients. ( 27935813 )
2016
21
Conduct protocol in emergency: Acute adrenal insufficiency. ( 27992012 )
2016
22
Histoplasmosis with Addisonian Crisis: Call for Bird Control. ( 26162388 )
2015
23
Addisonian Crisis after Missed Diagnosis of Posttraumatic Hypopituitarism. ( 26239458 )
2015
24
Addisonian Crisis Due to Antitubercular Therapy. ( 25772943 )
2015
25
Addisonian crisis in a dog treated with phenobarbitone. ( 25817975 )
2015
26
Peri-portal lymphedema in association with an acute adrenal insufficiency: case report. ( 24661563 )
2014
27
Systemic lupus erythematosus presenting as acute adrenal insufficiency: a rare clinical presentation. ( 24669348 )
2014
28
Transient acute adrenal insufficiency associated with adenovirus serotype 40 infection. ( 24928932 )
2014
29
Acute adrenal insufficiency as a first presentation of myelodysplastic syndrome and sigmoid colon adenocarcinoma: a case report. ( 25988040 )
2014
30
Rare presentation of shock and acute mesenteric ischaemia secondary to acute adrenal insufficiency in an 11-year-old male. ( 22970910 )
2013
31
Idiopathic bilateral adrenal haemorrhage related to acute adrenal insufficiency. ( 23729712 )
2013
32
Acute adrenal insufficiency following arthroplasty: a case report and review of the literature. ( 24028157 )
2013
33
Acute adrenal insufficiency due to primary antiphospholipid antibody syndrome. ( 24251172 )
2013
34
Addisonian crisis secondary to bilateral adrenal metastases in rectal carcinoma: report of a rare case and literature review. ( 22890387 )
2013
35
A case of Addisonian crisis, acute renal failure, vesiculobullous rash, rhabdomyolysis, neurological disturbances and prolonged viraemia in a patient on long term steroids. ( 23369888 )
2013
36
Addisonian crisis and severe acidosis in a cat: a case of feline hypoadrenocorticism. ( 23482253 )
2013
37
Acute adrenal insufficiency in cervical spinal cord injury. ( 22120347 )
2012
38
A case of acute adrenal insufficiency unmasked during sunitinib treatment for metastatic renal cell carcinoma. ( 22581915 )
2012
39
Acute adrenal insufficiency associated with tuberculous vertebral osteomyelitis and lymphadenopathy: case report. ( 22649455 )
2012
40
Acute adrenal insufficiency in a neonate with bilateral adrenal hemorrhage and combined prothrombotic risk factors. ( 22652827 )
2012
41
Acute adrenal insufficiency. ( 22712152 )
2012
42
Community acquired bilateral upper lobe pneumonia with acute adrenal insufficiency: A new face of Achromobacter Xylosoxidans. ( 23173016 )
2012
43
A strategy for management of intraoperative Addisonian crisis during coronary artery bypass grafting. ( 22269144 )
2012
44
Acquired long QT interval in a recurrent septic female patient with polymorphic ventricular tachycardia due to primary acute adrenal insufficiency. ( 21161542 )
2011
45
Acute adrenal insufficiency due to bilateral adrenal hemorrhage. ( 21466057 )
2011
46
Addisonian crisis in a young man with atypical anorexia nervosa. ( 21178996 )
2011
47
Manchester United induced addisonian crisis. ( 22174325 )
2011
48
Hypoglycaemic seizure and neonatal acute adrenal insufficiency after maternal exposure to prednisone during pregnancy: a case report. ( 19902248 )
2010
49
Primary antiphospholipid syndrome presenting as hyponatremic hypertensive syndrome and acute adrenal insufficiency following it: a rare case. ( 19365633 )
2009
50
Acute adrenal insufficiency may affect outcome in the trauma patient. ( 19385286 )
2009

Variations for Acute Adrenal Insufficiency

Expression for Acute Adrenal Insufficiency

Search GEO for disease gene expression data for Acute Adrenal Insufficiency.

Pathways for Acute Adrenal Insufficiency

Pathways related to Acute Adrenal Insufficiency according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.2 CYP11A1 CYP21A2 POMC
2 11.46 IL6 POMC
3
Show member pathways
11.34 CYP11A1 POMC
4 11.24 IL6 POMC
5 11.1 CYP11A1 CYP21A2 POMC
6
Show member pathways
11.08 CYP11A1 CYP21A2
7
Show member pathways
10.74 CYP11A1 CYP21A2 POMC

GO Terms for Acute Adrenal Insufficiency

Biological processes related to Acute Adrenal Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid metabolic process GO:0008202 9.32 CYP11A1 CYP21A2
2 regulation of blood pressure GO:0008217 9.26 POMC REN
3 steroid biosynthetic process GO:0006694 9.16 CYP11A1 CYP21A2
4 sterol metabolic process GO:0016125 8.96 CYP11A1 CYP21A2
5 glucocorticoid biosynthetic process GO:0006704 8.62 CYP11A1 CYP21A2

Molecular functions related to Acute Adrenal Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.16 CYP11A1 CYP21A2
2 iron ion binding GO:0005506 8.96 CYP11A1 CYP21A2
3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 8.62 CYP11A1 CYP21A2

Sources for Acute Adrenal Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
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43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
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52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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