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MCID: ACT249
MIFTS: 40

Acute Asthma

Categories: Genetic diseases, Immune diseases, Mental diseases, Rare diseases, Respiratory diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Acute Asthma

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MalaCards integrated aliases for Acute Asthma:

Name: Acute Asthma 12
Asthma, Severe, Susceptibility to 6

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Respiratory diseases Immune diseases Mental diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0080810
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Summaries for Acute Asthma

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Disease Ontology : 12 An asthma that is characterized by severe and sudden onset of increasing wheezing, airways closing, smooth muscle contraction, mucus plugging and lower airway edema that may be reversible upon treatment.

MalaCards based summary : Acute Asthma, also known as asthma, severe, susceptibility to, is related to status asthmaticus and chronic asthma. An important gene associated with Acute Asthma is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways are Folate Metabolism and Immune response Fc epsilon RI pathway. The drugs Prednisone and Budesonide have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, t cells and heart, and related phenotypes are hematopoietic system and immune system

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Related Diseases for Acute Asthma

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Diseases in the Asthma family:

Chronic Asthma Acute Asthma
Adult-Onset Severe Asthma

Diseases related to Acute Asthma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 225)
# Related Disease Score Top Affiliating Genes
1 status asthmaticus 31.6 RNASE3 IL5 ADRB2
2 chronic asthma 30.3 RNASE3 IL5 IL4 ALOX5
3 bronchiolitis 30.1 RNASE3 IL5 IL4
4 bronchitis 30.0 RNASE3 IL5 IL4
5 ige responsiveness, atopic 30.0 RNASE3 IL5 IL4
6 peanut allergy 29.8 IL5 IL4
7 strongyloidiasis 29.7 IL5 IL4
8 common cold 29.6 RNASE3 IL5 IL4
9 hypereosinophilic syndrome 29.6 RNASE3 IL5 IL4 ALOX5
10 respiratory failure 29.6 SCGB1A1 RNASE3 IL5 ALOX5 ADRB2
11 allergic bronchopulmonary aspergillosis 29.6 IL5 IL4
12 pollen allergy 29.6 RNASE3 IL5 ADRB2
13 asthma 29.6 SCGB1A1 RNASE3 IL5 IL4 ALOX5AP ALOX5
14 proteasome-associated autoinflammatory syndrome 1 29.5 RNASE3 IL5 IL4 ALOX5
15 allergic rhinitis 29.5 RNASE3 IL5 IL4 ALOX5
16 schistosomiasis 29.4 RNASE3 IL5 IL4
17 conjunctival disease 29.4 RNASE3 IL5 IL4
18 onchocerciasis 29.4 RNASE3 IL5 IL4
19 food allergy 29.4 RNASE3 IL5 IL4
20 dermatitis 29.4 RNASE3 IL5 IL4
21 dermatitis, atopic 29.3 RNASE3 IL5 IL4
22 chlamydia 29.3 IL5 IL4
23 pneumonia 29.3 SCGB1A1 IL5 IL4
24 allergic asthma 29.2 SCGB1A1 RNASE3 IL5 IL4 ALOX5
25 rhinitis 29.1 SCGB1A1 RNASE3 IL5 IL4
26 allergic disease 29.1 RNASE3 IL5 IL4 ADRB2
27 pulmonary disease, chronic obstructive 28.8 SCGB1A1 RNASE3 IL5 IL4 ADRB2
28 lung disease 28.6 SCGB1A1 RNASE3 IL5 IL4 ADRB2
29 near-fatal asthma 11.0
30 thunderstorm triggered asthma 11.0
31 tremor 10.4
32 pneumothorax 10.3
33 loeffler endocarditis 10.2 RNASE3 IL5
34 disseminated eosinophilic collagen disease 10.2 RNASE3 IL5
35 patulous eustachian tube 10.2 RNASE3 IL5
36 metabolic acidosis 10.2
37 pemphigoid gestationis 10.2 RNASE3 IL5
38 paragonimiasis 10.2 RNASE3 IL5
39 vasomotor rhinitis 10.2 RNASE3 IL5
40 wells syndrome 10.2 RNASE3 IL5
41 chronic eosinophilic pneumonia 10.2 RNASE3 IL5
42 cellulitis 10.1 RNASE3 IL5
43 exercise-induced bronchoconstriction 10.1 RNASE3 ALOX5
44 echinococcosis 10.1 RNASE3 IL5
45 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.1
46 churg-strauss syndrome 10.1 RNASE3 IL5
47 cyanosis, transient neonatal 10.1
48 47,xyy 10.1
49 cytokine deficiency 10.1
50 vernal conjunctivitis 10.1 RNASE3 IL4

Graphical network of the top 20 diseases related to Acute Asthma:



Diseases related to Acute Asthma
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Symptoms & Phenotypes for Acute Asthma

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MGI Mouse Phenotypes related to Acute Asthma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 ADRB2 ALOX5 ALOX5AP IL4 IL5 SCGB1A1
2 immune system MP:0005387 9.1 ADRB2 ALOX5 ALOX5AP IL4 IL5 SCGB1A1
Sources

Drugs & Therapeutics for Acute Asthma

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Drugs for Acute Asthma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
2
Budesonide Approved Phase 4 51333-22-3 63006 5281004
3
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
4
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
5
Procaterol Approved, Investigational Phase 4 72332-33-3 688561
6
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
7
Azithromycin Approved Phase 4 83905-01-5 55185 447043
8 Bromides Phase 4
9 Hydrocortisone hemisuccinate Phase 4
10 Hydrocortisone 17-butyrate 21-propionate Phase 4
11 Sympathomimetics Phase 4
12 Hormones Phase 4
13 Tocolytic Agents Phase 4
14 Anticonvulsants Phase 4
15 Anti-Arrhythmia Agents Phase 4
16 Anesthetics Phase 4
17 Calcium, Dietary Phase 4
18 Analgesics Phase 4
19 calcium channel blockers Phase 4
20 Formoterol Fumarate Phase 4
21 Anti-Infective Agents Phase 4
22 Anti-Bacterial Agents Phase 4
23
Calcium Nutraceutical Phase 4 7440-70-2 271
24
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
25
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
26
mometasone furoate Approved, Investigational, Vet_approved Phase 3 83919-23-7
27 Pharmaceutical Solutions Phase 3
28 Anti-Allergic Agents Phase 3
29 Dermatologic Agents Phase 3
30 BB 1101 Phase 3
31
Montelukast Approved Phase 2 158966-92-8 5281040
32 Hormone Antagonists Phase 2
33 Respiratory System Agents Phase 2
34 Anti-Asthmatic Agents Phase 2
35 Leukotriene Antagonists Phase 2
36 Ancrod Approved, Investigational 9046-56-4
37
tannic acid Approved 1401-55-4
38
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
39
Fenoterol Approved, Investigational 13392-18-2 3343
40 HIV Protease Inhibitors
41
protease inhibitors

Interventional clinical trials:

(show top 50) (show all 54)
# Name Status NCT ID Phase Drugs
1 Treatment of Acute Asthma in ER With Combination of Systemic Steroids and Inhaled Steroids Unknown status NCT00397267 Phase 4 inhalation of corticosteroids
2 Impact of Continuous Positive Airway Pressure on the Treatment of Acute Asthma Exacerbation Completed NCT01403467 Phase 4
3 Assessment of the Effect of Oral Montelukast as Additional Treatment in the Management of Patients With Acute Severe Asthma. Completed NCT01011452 Phase 4 Montelukast;Placebo
4 Phase 4 Study of Oral Montelukast Hospitalized Preschool Children Completed NCT03369119 Phase 4 Montelukast 4 Mg Oral Granule;Placebos
5 Efficacy of a Loading Dose of IV Salbutamol in Children Admitted to a PICU for Severe Acute Asthma or Severe Acute Wheeze Completed NCT03493503 Phase 4 Salbutamol;Sodium Chloride 0.9%
6 Budesonide Inhalation Suspension for Acute Asthma in Children Completed NCT00393367 Phase 4 Budesonide inhalation suspension (0.5 mg/2mL) 2mg, albuterol (5mg/mL) 7.5 or 10mg;Prednisolone, prednisone, or methylprednisolone;Albuterol, ipratropium bromide;Ipratropium bromide
7 A Randomized Double Blind Comparison Between Single Doses of Symbicort Turbuhaler (Budesonide/Formoterol Combination), Formoterol, Salbutamol and Placebo in Repeated AMP-challenges in Patients With Mild - to Moderate Asthma. Investigating the Supplementary Value of the Budesonide Component Within Symbicort When Tested in a Model of Slow Onset Acute Asthma Completed NCT00272753 Phase 4 budesonide/formoterol Turbuhaler;formoterol Turbuhaler;salbutamol
8 Comparative Study on the Efficacy and Safety of Procaterol vs Salbutamol Given Via Metered Dose Inhaler With Spacer in the Management of Acute Asthma Attack in the Emergency Room Completed NCT01091337 Phase 4 Procaterol;Salbutamol
9 Comparison of Hospital Admission Rates and Plasma(s)-Albuterol Levels in Children Treated With Racemic Albuterol Versus Levalbuterol for Acute Asthma Exacerbations: A Randomized Double-Blind Clinical Trial Completed NCT00585039 Phase 4 xopenex
10 Positive Expiratory Pressure for the Treatment of Acute Asthma Exacerbations in Children: A Randomized Controlled Trial Completed NCT02494076 Phase 4 EzPAP
11 Comparasion of Efficacy of Nebulized Magnesium Sulphate With Intravenous Magnesium Sulphate in Children With Acute Asthma Recruiting NCT04497766 Phase 4 Nebulized Magnesium sulfate;Intravenous magnesium sulphate
12 A Pilot Study to Determine the Most Effective Dose of Arformoterol for Treating Acute Asthmatic Patients Presenting to the Emergency Department and to Evaluate Its Side Effect and Safety Profile When Used in This Clinical Situation. Terminated NCT00819637 Phase 4 arformoterol (RR formoterol);placebo;levalbuterol
13 A Double-Blind, Randomized, Placebo-Controlled Trial of Azithromycin in Children Hospitalized With Acute Asthma Exacerbations Terminated NCT02003911 Phase 4 Azithromycin;Placebo
14 Non Invasive Ventilation in Acute Asthma Unknown status NCT00510991 Phase 3
15 A Phase III, Randomized, Active-Controlled, Parallel-Group Clinical Trial to Study the Efficacy and Long-Term Safety of Mometasone Furoate/Formoterol Fumarate (MF/F, MK-0887A [SCH418131]), Compared With Mometasone Furoate (MF, MK-0887 [SCH032088]), in Children With Persistent Asthma Completed NCT02741271 Phase 3 MF MDI 100 mcg BID (Open Label);MF/F MDI 100/10 mcg BID;MF MDI 100 mcg BID;Albuterol/Salbutamol PRN;Prednisone/Prednisolone
16 The Efficacy of Nebulized Procaterol Versus Nebulized Salbutamol for the Treatment of Moderate Acute Asthma: a Randomized, Double-blind, Parallel Group Study Completed NCT00990847 Phase 3 Procaterol, Salbultamol
17 A Multicenter, Randomized, Double-Blind Study Comparing the Clinical Effects of Intravenous Montelukast With Placebo in Patients With Acute Asthma Completed NCT00092989 Phase 3 montelukast sodium;placebo
18 A Randomized Double Blinded Placebo Controlled Trial of One Versus Two Doses of Oral Dexamethasone for the Treatment of Acute Asthma Exacerbation in the Pediatric Emergency Department (ED) Completed NCT02725008 Phase 3 Dexamethasone;placebo
19 A Multicenter, Randomized, Double-Blind Study Comparing the Clinical Effects of Intravenous Montelukast With Placebo in Pediatric Patients (Ages 6 to 14 Years) With Acute Asthma Completed NCT00117338 Phase 3 montelukast sodium;Comparator: placebo (unspecified)
20 Effectiveness of Salbutamol Administration by Nebulizer Versus Metered Dose Inhaler With Spacer in Acute Asthma in Children in Suez Canal University Hospital Emergency Department: A Randomized Control Trial Completed NCT03816267 Phase 3 Salbutamol
21 A Randomized, Double-Blind Study to Determine the Efficacy of Levalbuterol Versus Racemic Albuterol in the Treatment of Acute Asthma Completed NCT00667407 Phase 3 Levalbuterol 1.25 mg;Racemic Albuterol Sulfate
22 Study of Montelukast In ChiLdrEn With Sickle Cell Disease (SMILES) Not yet recruiting NCT04351698 Phase 2, Phase 3 Montelukast
23 Steroids In The Management Of Acute Asthma Exacerbations In Children, Which Form Is More Suitable? Unknown status NCT03204760 Phase 2 Dexamethasone 8Mg Solution for Injection;Prednisolone Oral, Per 5 Mg
24 Magnesium Nebulization Utilization in Management of Pediatric Asthma Completed NCT01429415 Phase 2 Magnesium Sulfate Sandoz;Sodium Chloride , USP PPC
25 Use of Aerosolized rhDNase (Pulmozyme®) in Emergency Department Adults With Refractory Acute Asthma: A Pilot Study Completed NCT00169962 Phase 2 rhDNAse (pulmozyme)
26 Can Montelukast Shorten Corticosteroid Therapy In Children With Mild To Moderate Acute Asthma? Completed NCT00213252 Phase 2 Montelukast plus prednisolone;Prednisolone
27 Pragmatic RCT of High-dose Oral Montelukast for Moderate and Severe Pediatric Acute Asthma Exacerbations Not yet recruiting NCT03277170 Phase 2 Montelukast Oral Granules
28 Nebulized Budesonide Combined With Systemic Corticosteroid in Acute Severe Asthma Managed in the Emergency Department: A Randomized Controlled Trial Recruiting NCT04016220 Phase 1 Budesonide;normal saline
29 β2AR Polymorphisms and Albuterol Responsiveness in Acute Asthma Unknown status NCT01016444
30 Human Model of Rhinovirus Induced Acute Asthma Exacerbations Unknown status NCT01159782
31 Comparison of Breath-Enhanced and T-Piece Nebulizers in Children With Acute Asthma Unknown status NCT02566902 Albuterol
32 Comparison Efficacy of Nebulized Magnesium Sulphate to Intravenous Magnesium Sulphate in Children With Severe Acute Asthma Unknown status NCT02112305 isotonic magnesium sulphate;50% magnesium sulphate
33 Exhaled Breath Biomarkers in Acute Asthma: A Feasibility Study Unknown status NCT03084016
34 Assessment of the Severity of Acute Asthma Exacerbation in Children Attending the Emergency Departments to Predict Outcomes by Modified Pulmonary Index Score Unknown status NCT03190759
35 A Pilot and Feasibility Study of Mobile-Based Asthma Action Plans Completed NCT01514760
36 Emergency Department (ED)-Directed Interventions to Improve Outcomes After Asthma Exacerbations Completed NCT01079000
37 Personalized Medicine, Biomarker-based Study of Optimal Albuterol Regimens for Acute Asthma Exacerbations: DBRCT Pilot Study Completed NCT01196377 Albuterol
38 Heliox and Posture Optimize Action of Nebulization With Bronchodilators for Asthma Attacks. Randomized Trial. Completed NCT00922350
39 Feasibility of an ED-initiated Online Asthma Management Program for Urban Teens (Puff City-ED) Completed NCT01695031
40 A Pilot Study Determining Mechanisms of Acute Asthma Exacerbations Through Detailed Molecular Analysis of Airway Secretions and Tissues Completed NCT00603629
41 A Comparison of Levalbuterol Plus Ipratropium With Levalbuterol Alone in the Treatment of Acute Asthma Exacerbation Completed NCT00583778 ipratropium
42 Outdoor Allergen Exposure, Sensitivity, and Acute Asthma Completed NCT00043992
43 Mechanisms of Interplay Between Allergy and Viruses in Asthma: A Human Model of Rhinovirus Induced Acute Asthma Exacerbations Completed NCT01773590
44 Comparison of Single Dose Versus Two Doses of Oral Dexamethasone in the Management of Acute Asthma Exacerbations in the Pediatric Emergency Department. Completed NCT00942201 Dexamethasone;Dexamethasone
45 Efficacy of the PARI LC Sprint Sp Nebulizer for Acute Asthma Attack in Hospitalized Children Less Than 36 Months of Age Completed NCT01649401
46 Dexamethasone Tolerability in the Treatment of Acute Asthma in Children Completed NCT00973687 Ora Sweet;Dexamethasone
47 Patient Reported Outcomes for Acute Asthma Care Treatment Recruiting NCT04349020
48 Peak Expiratory Flow Rate (PEFR) for Emergency Department Management of Acute Asthma Recruiting NCT03420651
49 A Pilot Study Examining Changes in Nasal IL-1 During Acute Asthma Exacerbation in Adolescents Not yet recruiting NCT04748055
50 Randomized Controlled Trial of Oral Montelukast Added to Standard Therapy for Acute Asthma Exacerbations in Children Age 6 to 14 Years Terminated NCT00353184 Montelukast 5-mg orally added to standard therapy

Search NIH Clinical Center for Acute Asthma

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Genetic Tests for Acute Asthma

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Anatomical Context for Acute Asthma

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MalaCards organs/tissues related to Acute Asthma:

40
Smooth Muscle, T Cells, Heart, Neutrophil, Endothelial, Spleen, Skin
Sources

Publications for Acute Asthma

About this section

Articles related to Acute Asthma:

(show top 50) (show all 3508)
# Title Authors PMID Year
1
Pilot Study of Peak Plasma Concentration After High-Dose Oral Montelukast in Children With Acute Asthma Exacerbations. 61
32960980 2021
2
Implementation of a Critical Care Asthma Pathway in the PICU. 61
33604577 2021
3
Clinical Phenotypes of Patients Hospitalized for an Asthma Exacerbation: Prognostic Implications. 61
33011298 2021
4
Impact of Type of Health Care Provider on Long Term Asthma Control. 61
33600737 2021
5
Systemic glucocorticoid at discharge after hospitalization for pediatric asthma: a prospective pilot study. 61
33492180 2021
6
Stratifying asthma severity in children using cough sound analytic technology. 61
31638844 2021
7
Can low-dose dexamethasone be used instead of prednisolone in acute asthma attacks? 61
33593742 2021
8
Attack, flare-up, or exacerbation? The terminology preferences of patients with severe asthma. 61
31490698 2021
9
Intravenous Magnesium Sulfate for Acute Asthma Exacerbation in Children and Adults. 61
33587577 2021
10
Novel machine learning can predict acute asthma exacerbation. 61
33440184 2021
11
Adherence to medication among adult asthma patients in the Middle East and North Africa: results from the ESMAA study. 61
33253971 2021
12
Impact of obstructive sleep apnea on assisted ventilation in children with asthma exacerbation. 61
33428827 2021
13
Show Me The Money…Saved! Cost Savings From Acute Asthma Care in the School-Based Health Center. 61
33438512 2021
14
Factors Associated With First Medication Time for Children Treated in the Emergency Department for Asthma. 61
30281550 2021
15
Nebulised magnesium with salbutamol in refractory acute asthma. 61
33318043 2021
16
Th2 cell markers in peripheral blood increase during an acute asthma exacerbation. 61
32750154 2021
17
Difficult diagnosis: A case report of thyroid storm obscured by acute asthma exacerbation and concurrent H1N1 influenza. 61
33583620 2021
18
Efficacy and safety of once-daily single-inhaler triple therapy (FF/UMEC/VI) versus FF/VI in patients with inadequately controlled asthma (CAPTAIN): a double-blind, randomised, phase 3A trial. 61
32918892 2021
19
Characterization of Negative Allosteric Modulators of the Calcium-Sensing Receptor for Repurposing as a Treatment of Asthma. 61
33115824 2021
20
Acute asthma exacerbations: tips from the shop floor. 61
33377848 2020
21
Emergency department treatment of asthma in children: A review. 61
33392563 2020
22
Reply to Lipworth et al.: Don't Forget about Facilitatory Effects of Corticosteroids on β2-Adrenoceptors in Acute Asthma. 61
32970450 2020
23
Don't Forget about Facilitatory Effects of Corticosteroids on β2-Adrenoceptors in Acute Asthma. 61
32970458 2020
24
Noninvasive Ventilation Use in Critically Ill Patients with Acute Asthma Exacerbations. 61
32663410 2020
25
Variability in care for children with severe acute asthma in Latin America. 61
33333632 2020
26
Methods and implementation of a pediatric asthma pharmacogenomic study in the emergency department setting. 61
33017130 2020
27
Long-term risk of pneumothorax in asthmatic children: A 12-year population-based cohort study. 61
33371147 2020
28
Fungal sensitization and positive fungal culture from sputum in children with asthma are associated with reduced lung function and acute asthma attacks respectively. 61
33274520 2020
29
Physiologically variable ventilation in a rabbit model of asthma exacerbation. 61
33070949 2020
30
The impact of maternal asthma during pregnancy on fetal growth and development: a review. 61
32825809 2020
31
Noninvasive Ventilation for Acute Asthma: The Neglected Sibling. 61
32755489 2020
32
Prevalence of viral respiratory infections amongst asthmatics: Results of a meta-regression analysis. 61
33190740 2020
33
Question 5: Magnesium Sulphate for Acute Asthma in children. 61
32600821 2020
34
Oscillometry for acute asthma in the pediatric emergency department: A feasibility study. 61
32652127 2020
35
Effect of Nebulized Magnesium vs Placebo Added to Albuterol on Hospitalization Among Children With Refractory Acute Asthma Treated in the Emergency Department: A Randomized Clinical Trial. 61
33231663 2020
36
Determinants of cough and caregivers' quality of life in pediatric asthma exacerbations. 61
33179390 2020
37
Reducing oral corticosteroids in severe asthma (ROSA Project): a nationwide Portuguese consensus. 61
33177008 2020
38
Corticosteroid choice and clinical outcomes for asthma exacerbations in the primary care setting. 61
33106059 2020
39
Association of asthma severity and educational attainment at age 6-7 years in a birth cohort: population-based record-linkage study. 61
33177228 2020
40
Spatiotemporal characteristics of asthma emergency department presentations in diverse geographical and climatic regions, Queensland, Australia. 61
33230971 2020
41
Use of the ReCIVA device in breath sampling of patients with acute breathlessness: a feasibility study. 61
33263021 2020
42
Evaluating an Air Quality Health Index (AQHI) amendment for communities impacted by residential woodsmoke in British Columbia, Canada. 61
32791025 2020
43
Impact of antipyretics on acute asthma exacerbation during respiratory infection-A nationwide population-based study. 61
32331972 2020
44
Adding nebulized corticosteroids to systemic corticosteroids for acute asthma in children: A systematic review with meta-analysis. 61
32658381 2020
45
Pediatric acute asthma scoring systems: a systematic review and survey of UK practice. 61
33145551 2020
46
Prevalence and risk factors of lactic acidosis in children with acute moderate and severe asthma, a prospective observational study. 61
33089387 2020
47
The Impact of Terbutaline as Adjuvant Therapy in the Treatment of Severe Asthma in the Pediatric Emergency Department. 61
33136831 2020
48
Biologic treatment options for severe asthma. 61
33212388 2020
49
Fractional exhaled nitric oxide response to oral corticosteroids in children with mild-to-moderate asthma: Influence of race. 61
32621994 2020
50
Intravenous Magnesium Sulfate for Acute Asthma Exacerbation in Adults. 61
32574392 2020
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Variations for Acute Asthma

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ClinVar genetic disease variations for Acute Asthma:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 IL12B IL12B, 4237G-A SNV Uncertain significance 14055
Sources

Expression for Acute Asthma

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Search GEO for disease gene expression data for Acute Asthma.
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Pathways for Acute Asthma

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Pathways related to Acute Asthma according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Folate Metabolism 1
Show member pathways
 11.83 IL4 ALOX5AP ALOX5
2
Immune response Fc epsilon RI pathway 23
Show member pathways
 11.46 IL5 IL4 ALOX5AP ALOX5
3
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.42 IL5 IL4
4
IgA-Producing B Cells in the Intestine 64
11.34 IL5 IL4
5
Lung fibrosis 1
11.31 IL5 IL4
6
IL4-mediated signaling events 1
11.29 IL5 IL4
7
Th2 Differentiation Pathway 64
11.14 IL5 IL4
8
Inflammatory Response Pathway 1
10.98 IL5 IL4
9
Development and heterogeneity of the ILC family 1
10.94 IL5 IL4
10
Cytokines and Inflammatory Response 1
10.87 IL5 IL4
11
OX40 Pathway 63
10.78 IL5 IL4
12
Eicosanoid Synthesis 1
10.64 ALOX5AP ALOX5
13
IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 64
10.23 IL5 IL4
14
Leukotriene modifiers pathway, Pharmacodynamics 60
9.86 ALOX5AP ALOX5
Sources

GO Terms for Acute Asthma

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Cellular components related to Acute Asthma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.55 SCGB1A1 RNASE3 IL5 IL4 ALOX5
2 extracellular space GO:0005615 9.35 SCGB1A1 RNASE3 IL5 IL4 ALOX5
3 nuclear envelope GO:0005635 8.8 SCGB1A1 ALOX5AP ALOX5

Biological processes related to Acute Asthma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.61 IL5 IL4 ALOX5
2 positive regulation of B cell proliferation GO:0030890 9.46 IL5 IL4
3 positive regulation of bone mineralization GO:0030501 9.4 ALOX5 ADRB2
4 innate immune response in mucosa GO:0002227 9.37 RNASE3 IL4
5 leukotriene metabolic process GO:0006691 9.32 ALOX5AP ALOX5
6 lipoxygenase pathway GO:0019372 9.26 ALOX5AP ALOX5
7 leukotriene biosynthetic process GO:0019370 9.16 ALOX5AP ALOX5
8 lipoxin biosynthetic process GO:2001301 8.96 ALOX5AP ALOX5
9 leukotriene production involved in inflammatory response GO:0002540 8.62 ALOX5AP ALOX5

Molecular functions related to Acute Asthma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 arachidonate 5-lipoxygenase activity GO:0004051 8.62 ALOX5AP ALOX5
Sources

Sources for Acute Asthma

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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