MCID: ACT177
MIFTS: 35

Acute Basophilic Leukemia

Categories: Blood diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Acute Basophilic Leukemia

MalaCards integrated aliases for Acute Basophilic Leukemia:

Name: Acute Basophilic Leukemia 12 58 17 70

Classifications:

Orphanet: 58  
Rare haematological diseases


External Ids:

Disease Ontology 12 DOID:0080795
NCIt 50 C3164
MESH via Orphanet 45 D015471
ICD10 via Orphanet 33 C94.7
UMLS via Orphanet 71 C0023437
Orphanet 58 ORPHA86849
UMLS 70 C0023437

Summaries for Acute Basophilic Leukemia

Disease Ontology : 12 An acute myeloid leukemia that is characterized by primary differentiation to basophils.

MalaCards based summary : Acute Basophilic Leukemia is related to acute leukemia and leukemia, chronic myeloid. An important gene associated with Acute Basophilic Leukemia is GATA1 (GATA Binding Protein 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and NF-kappaB Signaling. The drugs Aldesleukin and Busulfan have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone marrow and liver, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 73 Acute basophilic leukemia is a rare form of acute myeloid leukemia where blasts are accompanied by... more...

Related Diseases for Acute Basophilic Leukemia

Diseases related to Acute Basophilic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
# Related Disease Score Top Affiliating Genes
1 acute leukemia 29.4 MPO IL3RA GATA1 ETV6
2 leukemia, chronic myeloid 28.9 MYB MPO GATA1 ETV6 CSF2RA
3 leukemia, acute lymphoblastic 28.6 MYB MPO IL3RA GATA1 ETV6
4 myelodysplastic syndrome 28.6 MYB MPO IL3RA GATA1 ETV6
5 chromosomal triplication 10.2
6 urticaria 10.1
7 down syndrome 10.0
8 langerhans cell histiocytosis 10.0
9 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.0
10 deficiency anemia 10.0
11 gastric ulcer 10.0
12 disseminated intravascular coagulation 10.0
13 leukemia 10.0
14 thrombocytopenia 10.0
15 essential thrombocythemia 10.0
16 histiocytosis 10.0
17 liver disease 10.0
18 peritonitis 10.0
19 mast-cell leukemia 10.0
20 exophthalmos 10.0
21 acute myeloblastic leukemia with maturation 10.0
22 cytokine deficiency 10.0
23 granulocytopenia 10.0
24 splenomegaly 10.0
25 acute liver failure 10.0
26 tonsil cancer 10.0 MYB ETV6
27 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 9.9 MPO ETV6
28 chromosomal duplication syndrome 9.9 GATA1 ETV6
29 childhood leukemia 9.9 MPO ETV6
30 hereditary pulmonary alveolar proteinosis 9.8 IL3RA CSF2RA
31 acute megakaryocytic leukemia 9.7 MPO GATA1 ETV6
32 pollen allergy 9.7 MPO IL3RA
33 b-lymphoblastic leukemia/lymphoma 9.7 MPO ETV6
34 precursor t-cell acute lymphoblastic leukemia 9.7 MYB MPO ETV6
35 myeloproliferative neoplasm 9.7 MPO GATA1 ETV6
36 myelofibrosis 9.7 MPO GATA1 ETV6
37 aplastic anemia 9.7 MPO GATA1 CSF2RA
38 acute promyelocytic leukemia 9.6 MPO GATA1 ETV6
39 leukemia, chronic lymphocytic 9.3 MYB IL3RA CSF2RA
40 leukemia, acute myeloid 9.1 MYB MPO IL3RA GATA1 ETV6

Graphical network of the top 20 diseases related to Acute Basophilic Leukemia:



Diseases related to Acute Basophilic Leukemia

Symptoms & Phenotypes for Acute Basophilic Leukemia

GenomeRNAi Phenotypes related to Acute Basophilic Leukemia according to GeneCards Suite gene sharing:

26 (show all 47)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-100 10.29 MYB
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-102 10.29 CSF2RA
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-115 10.29 CSF2RA
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-120 10.29 MYB
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-121 10.29 MYB
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-122 10.29 MYB
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 10.29 CSF2RA
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 10.29 MYB
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-146 10.29 CSF2RA
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-147 10.29 MYB
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-161 10.29 MYB
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-164 10.29 MYB
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-169 10.29 MYB
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-176 10.29 ETV6
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-177 10.29 MYB
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 10.29 MYB
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-198 10.29 ETV6
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 10.29 MYB
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-32 10.29 CSF2RA
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 10.29 CSF2RA
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 10.29 MYB
22 Decreased shRNA abundance (Z-score < -2) GR00366-A-73 10.29 CSF2RA ETV6 MYB
23 Decreased shRNA abundance (Z-score < -2) GR00366-A-83 10.29 MYB
24 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 10.29 CSF2RA
25 Decreased shRNA abundance (Z-score < -2) GR00366-A-96 10.29 CSF2RA
26 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.98 CSF2RA
27 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.98 CSF2RA
28 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.98 CSF2RA
29 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.98 CSF2RA
30 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.98 MPO
31 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.98 CSF2RA
32 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.98 CSF2RA
33 Increased shRNA abundance (Z-score > 2) GR00366-A-153 9.98 CSF2RA
34 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.98 MPO
35 Increased shRNA abundance (Z-score > 2) GR00366-A-184 9.98 MPO
36 Increased shRNA abundance (Z-score > 2) GR00366-A-215 9.98 CSF2RA
37 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.98 CSF2RA
38 Increased shRNA abundance (Z-score > 2) GR00366-A-28 9.98 MYB
39 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.98 MPO
40 Increased shRNA abundance (Z-score > 2) GR00366-A-40 9.98 MPO
41 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.98 CSF2RA
42 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.98 MPO
43 Increased shRNA abundance (Z-score > 2) GR00366-A-65 9.98 CSF2RA
44 Increased shRNA abundance (Z-score > 2) GR00366-A-68 9.98 CSF2RA
45 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.98 MPO
46 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.98 MPO
47 Reduced mammosphere formation GR00396-S 9.02 CSF2RA ETV6 GATA1 IL18R1 IL3RA

MGI Mouse Phenotypes related to Acute Basophilic Leukemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 ETV6 GATA1 IL18R1 IL3RA MPO MYB
2 immune system MP:0005387 9.1 ETV6 GATA1 IL18R1 IL3RA MPO MYB

Drugs & Therapeutics for Acute Basophilic Leukemia

Drugs for Acute Basophilic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aldesleukin Approved Phase 3 110942-02-4, 85898-30-2
2
Busulfan Approved, Investigational Phase 3 55-98-1 2478
3
Lenograstim Approved, Investigational Phase 3 135968-09-1
4
Cytarabine Approved, Investigational Phase 3 147-94-4 6253
5
Etoposide Approved Phase 3 33419-42-0 36462
6
Thioguanine Approved Phase 3 154-42-7 2723601
7
Daunorubicin Approved Phase 3 20830-81-3 30323
8
Aspartic acid Approved, Nutraceutical Phase 3 56-84-8 5960
9 Analgesics Phase 3
10 Alkylating Agents Phase 3
11 Anti-Retroviral Agents Phase 3
12 Anti-HIV Agents Phase 3
13 Interleukin-2 Phase 3
14 Analgesics, Non-Narcotic Phase 3
15 Immunologic Factors Phase 3
16 Anti-Infective Agents Phase 3
17 Antibiotics, Antitubercular Phase 3
18 Immunosuppressive Agents Phase 3
19 Antiviral Agents Phase 3
20 Antimetabolites Phase 3
21 Anti-Bacterial Agents Phase 3
22 Etoposide phosphate Phase 3
23 N-Methylaspartate Phase 3
24
asparaginase Phase 3
25
Mitoxantrone Approved, Investigational Phase 2 65271-80-9 4212
26
Lenalidomide Approved Phase 2 191732-72-6 216326
27
Bevacizumab Approved, Investigational Phase 2 216974-75-3
28
Idarubicin Approved Phase 2 58957-92-9 42890
29
tipifarnib Investigational Phase 1, Phase 2 192185-72-1 159324
30 Angiogenesis Inhibitors Phase 2
31 Antineoplastic Agents, Immunological Phase 2
32 Immunoglobulins Phase 2
33 Immunoglobulins, Intravenous Phase 2
34 Antibodies Phase 2
35 Antibodies, Monoclonal Phase 2
36
Sorafenib Approved, Investigational Phase 1 284461-73-0 216239 406563
37
Bortezomib Approved, Investigational Phase 1 179324-69-7 387447 93860
38
Entinostat Investigational Phase 1 209783-80-2
39
Alvocidib Experimental, Investigational Phase 1 146426-40-6, 131740-09-5 5287969
40 Protein Kinase Inhibitors Phase 1
41 Histone Deacetylase Inhibitors Phase 1

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Phase III Randomized Study of Induction Chemotherapy With or Without MDR-Modulation With PSC-833 (NSC # 648265, IND # 41121) Followed by Cytogenetic Risk-Adapted Intensification Therapy Followed by Immunotherapy With rIL-2 (NSC # 373364, IND # 1969) vs. Observation in Previously Untreated Patients With AML &lt; 60 Years Completed NCT00006363 Phase 3 cytarabine;daunorubicin hydrochloride;etoposide;valspodar;busulfan
2 The Treatment of Down Syndrome Children With Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS) Under the Age of 4 Years Active, not recruiting NCT00369317 Phase 3 asparaginase;daunorubicin hydrochloride;cytarabine;thioguanine;etoposide
3 A Phase II Study of Lenalidomide (REVLIMID, NSC-703813) for Previously Untreated Non-M3, Deletion 5q Acute Myeloid Leukemia (AML) in Patients Age 60 or Older Who Decline Remission Induction Chemotherapy Completed NCT00352365 Phase 2 lenalidomide
4 Phase II Study of Alvocidib (NSC 649890, Flavopiridol) in Timed Sequential Combination With Cytosine Arabinoside (Ara-C) and Mitoxantrone for Adults With Newly Diagnosed, Previously Untreated, Poor-Risk Acute Myelogenous Leukemias Completed NCT00407966 Phase 2 alvocidib;cytarabine;mitoxantrone hydrochloride
5 PHASE I-II STUDY OF IDARUBICIN, CYTARABINE AND R115777 (TIPIFARNIB, ZARNESTRA; 702818; IND 58359), A FARNESYLTRANSFERASE INHIBITOR, IN PATIENTS WITH HIGH-RISK MYELODYSPLASTIC SYNDROMES AND ACUTE MYELOID LEUKEMIAS Completed NCT00096122 Phase 1, Phase 2 cytarabine;idarubicin;tipifarnib
6 Randomized Phase II Trial of Idarubicin + Ara-C +/- Bevacizumab in Patients Age < 60 With Untreated Acute Myeloid Leukemia Terminated NCT00096148 Phase 2 idarubicin;cytarabine
7 A Phase 2 Study of EMD 121974 as Maintenance Therapy for Patinets With Acute Myeloid Leukemia in Complete Remission Terminated NCT00089388 Phase 2 cilengitide
8 A Phase I Dose-Escalation Study of R115777 (Tipifarnib) Plus PS-341 (Bortezomib) in Relapsed or Refractory Acute Leukemias Completed NCT00383474 Phase 1 Bortezomib;Tipifarnib
9 Phase I Dose Escalation Trial of the Raf Kinase Inhibitor BAY 43-9006 (NSC #724772) as Single Agent for Adults With Relapsed and Refractory Acute Leukemias and Chronic Myeloid Leukemia in Blast Crisis Completed NCT00131989 Phase 1 sorafenib tosylate
10 Phase I Study of BAY 43-9006 (NSC 724772) in Patients With Acute Leukemias, Myelodysplastic Syndromes and Chronic Myeloid Leukemia in Blast Phase Completed NCT00217646 Phase 1 Sorafenib Tosylate
11 A Phase I Study of XK469R (NSC 698215) in Patients With Refractory Hematologic Malignancies Completed NCT00095797 Phase 1 R(+)XK469
12 Phase I Dose-Finding Study of Eltrombopag Following High Dose Cytarabine and Mitoxantrone in Relapsed/Refractory Patients With Acute Myeloid Leukemia Terminated NCT01550185 Phase 1 eltrombopag olamine
13 A Phase I Study of Sorafenib in Combination With the Histone Deacetylase Inhibitor, Entinostat in Patients With Advanced Cancers Terminated NCT01159301 Phase 1 entinostat;sorafenib tosylate
14 A Dose Escalation Study of Flavopiridol (NSC 649890) Administered as a 30 Minute Loading Dose Followed by a 4-Hour Infusion in Patients With Relapsed and Refractory Acute Leukemias Terminated NCT00101231 Phase 1 alvocidib
15 A Phase I Study of PS-341 (Velcade, Bortezomib) in Combination With 17-allylamino-17-demethoxygeldanamycin (17-AAG) in Patients With Relapsed or Refractory Hematologic Malignancies Terminated NCT00103272 Phase 1 tanespimycin;bortezomib
16 Target: Identification for High Risk Childhood AML Based on Genome-Wide Analysis Completed NCT01076569

Search NIH Clinical Center for Acute Basophilic Leukemia

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Thioguanine

Genetic Tests for Acute Basophilic Leukemia

Anatomical Context for Acute Basophilic Leukemia

MalaCards organs/tissues related to Acute Basophilic Leukemia:

40
Myeloid, Bone Marrow, Liver, Bone, Tonsil

Publications for Acute Basophilic Leukemia

Articles related to Acute Basophilic Leukemia:

(show top 50) (show all 51)
# Title Authors PMID Year
1
Acute basophilic leukemia with U2AF1 mutation. 61
30827760 2019
2
[Philadelphia chromosome-positive acute lymphoblastic leukemia with basophilic blast features]. 61
31391365 2019
3
c-MYB and DMTF1 in Cancer. 61
30599775 2019
4
Acute basophilic leukemia associated with the t(16;21)(p11;q22)/FUS-ERG fusion gene. 61
29225830 2017
5
Acute basophilic leukemia with add(3)(q12) accompanied by histamine excess symptoms. 61
28424883 2017
6
Proposed diagnostic criteria and classification of basophilic leukemias and related disorders. 61
28090091 2017
7
Basophilia and megakaryoblastic differentiation in a case of acute myeloid leukemia: An unusual morphological combination. 61
26169238 2016
8
Acute basophilic leukemia presenting with maculopapular rashes and a gastric ulcer: A case report. 61
25364419 2014
9
Myelomastocytic leukemia: histopathological features, diagnostic criteria and differential diagnosis. 61
25025369 2014
10
Acute basophilic leukemia. 61
24949509 2014
11
A novel karyotype in acute myeloid leukemia with basophilia. 61
24552500 2014
12
Arsenic trioxide in treatment of de novo acute basophilic leukemia. 61
23422134 2013
13
A case of Langerhans cell histiocytosis following acute basophilic leukemia. 61
22895553 2013
14
Acute basophilic leukemia associated with loss of gene ETV6 and protean complications. 61
21576634 2011
15
Identification of a transforming MYB-GATA1 fusion gene in acute basophilic leukemia: a new entity in male infants. 61
21474671 2011
16
Acute basophilic leukemia in an infant with proptosis. 61
21393925 2011
17
Trisomy 19 and t(9;22) in a patient with acute basophilic leukemia. 61
22937382 2011
18
A case of acute basophilic leukemia arising from chronic myelogenous leukemia with development of t(7;8)(q32;q13). 61
18328951 2008
19
Monosomy 7 as the sole abnormality of an acute basophilic leukemia. 61
17213028 2007
20
[Picture in clinical hematology. Acute basophilic leukemia]. 61
17313070 2007
21
Imatinib resistant chronic myelogenous leukemia, BCR-ABL positive by chromosome and FISH analyses but negative by PCR, in a child progressing to acute basophilic leukemia: cytogenetic follow-up. 61
16965955 2006
22
Acute basophilic leukemia: case report. 61
15164378 2004
23
Acute basophilic leukemia with t(8;21). 61
15160925 2004
24
Acute basophilic leukemia lacking basophil-specific antigens: the importance of cytokine receptor expression in differential diagnosis. 61
11999362 2002
25
Differentiation of human basophils: an overview of recent advances and pending questions. 61
11927641 2002
26
Acute basophilic leukemia. 61
11722593 2001
27
[Basophilic differentiation of leukemic cells in a patient with acute leukemia carrying minor bcr/abl chimeric mRNA]. 61
11524847 2001
28
Acute basophilic leukemia presenting with abnormal liver function tests and the absence of blast cells in the peripheral blood. 61
10740808 2000
29
Diagnosis of acute basophilic leukemia. 61
10037024 1999
30
Protein tyrosine kinases in activation signal of human basophils through the immunoglobulin E receptor type l. 61
8604027 1996
31
An abnormal clone with monosomy 7 and trisomy 21 in the bone marrow of a child with congenital agranulocytosis (Kostmann disease) treated with granulocyte colony-stimulating factor. Evolution towards myelodysplastic syndrome and acute basophilic leukemia. 61
8536230 1995
32
Acute basophilic leukemia in a child. Anaphylactoid reaction and coagulopathy secondary to vincristine-mediated degranulation. 61
7804964 1995
33
[Acute basophilic leukemia]. 61
7847033 1994
34
[Acute basophilic leukemia with an intense erythroblastic reaction]. 61
8140501 1993
35
Acute basophilic leukemia and acute eosinophilic leukemia after therapy for non-Hodgkin's lymphoma. 61
8257517 1993
36
[Acute basophilic leukemia: a case report]. 61
7689662 1993
37
Acute basophilic leukemia. 61
1489389 1992
38
Acute basophilic leukemia. A case report. 61
1718580 1991
39
Evolution of the French-American-British (FAB) proposals. Is there a place for acute basophilic leukemia? 61
1862770 1991
40
Acute basophilic leukemia. A clinical, morphologic, and cytogenetic study of eight cases. 61
1862771 1991
41
[Atypical urticaria disclosing acute basophilic leukemia. Apropos of a case associated with hyperhistaminemia]. 61
2437851 1987
42
[Ultrastructural study of a case of acute basophilic leukemia--observation of the large membrane complexes and a hypothesis of basophil granule formation]. 61
3747173 1986
43
[Acute basophilic leukemia]. 61
3860999 1985
44
Acute basophilic leukemia. 61
6731465 1984
45
[Acute basophilic leukemia in a 75-year-old man. A clinical and cytological study with a review of the literature]. 61
6203233 1984
46
Mast cell leukemia and acute basophilic leukemia. Cytochemical studies. 61
747630 1978
47
[An autopsy case of acute basophilic leukemia (author's transl)]. 61
633630 1978
48
Follow-up of sixty two cases of acute basophilic leukemia. 61
667277 1978
49
[Acute basophilic leukemia with histamine excess symptoms (author's transl)]. 61
56471 1975
50
[Initial electron microscopy studies in 2 cases of acute basophilic leukemia]. 61
5532288 1970

Variations for Acute Basophilic Leukemia

Expression for Acute Basophilic Leukemia

Search GEO for disease gene expression data for Acute Basophilic Leukemia.

Pathways for Acute Basophilic Leukemia

GO Terms for Acute Basophilic Leukemia

Biological processes related to Acute Basophilic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of hematopoietic stem cell differentiation GO:1902036 8.62 MYB GATA1

Molecular functions related to Acute Basophilic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.33 MYB GATA1 ETV6
2 cytokine receptor activity GO:0004896 8.96 IL3RA CSF2RA
3 cytokine binding GO:0019955 8.62 IL3RA CSF2RA

Sources for Acute Basophilic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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