MCID: ACT177
MIFTS: 31

Acute Basophilic Leukemia

Categories: Blood diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Acute Basophilic Leukemia

MalaCards integrated aliases for Acute Basophilic Leukemia:

Name: Acute Basophilic Leukemia 60 17 74

Classifications:



External Ids:

MESH via Orphanet 46 D015471
ICD10 via Orphanet 35 C94.7
UMLS via Orphanet 75 C0023437
Orphanet 60 ORPHA86849
UMLS 74 C0023437

Summaries for Acute Basophilic Leukemia

MalaCards based summary : Acute Basophilic Leukemia is related to myelodysplastic syndrome and leukemia, chronic myeloid. An important gene associated with Acute Basophilic Leukemia is MYB (MYB Proto-Oncogene, Transcription Factor), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and NF-kappaB Signaling. Affiliated tissues include myeloid, bone and bone marrow, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 77 Acute basophilic leukemia is a rare form of acute myeloid leukemia where blasts are accompanied by... more...

Related Diseases for Acute Basophilic Leukemia

Graphical network of the top 20 diseases related to Acute Basophilic Leukemia:



Diseases related to Acute Basophilic Leukemia

Symptoms & Phenotypes for Acute Basophilic Leukemia

GenomeRNAi Phenotypes related to Acute Basophilic Leukemia according to GeneCards Suite gene sharing:

27 (show all 39)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.52 CSF2RA MYB MPO
2 Increased shRNA abundance (Z-score > 2) GR00366-A-101 10.52 ETV6
3 Increased shRNA abundance (Z-score > 2) GR00366-A-102 10.52 CSF2RA
4 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.52 CSF2RA
5 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.52 CSF2RA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.52 CSF2RA
7 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.52 MYB
8 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.52 MYB
9 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.52 MYB
10 Increased shRNA abundance (Z-score > 2) GR00366-A-126 10.52 MPO
11 Increased shRNA abundance (Z-score > 2) GR00366-A-137 10.52 CSF2RA ETV6
12 Increased shRNA abundance (Z-score > 2) GR00366-A-146 10.52 CSF2RA
13 Increased shRNA abundance (Z-score > 2) GR00366-A-147 10.52 MYB
14 Increased shRNA abundance (Z-score > 2) GR00366-A-151 10.52 CSF2RA ETV6
15 Increased shRNA abundance (Z-score > 2) GR00366-A-157 10.52 MPO
16 Increased shRNA abundance (Z-score > 2) GR00366-A-159 10.52 ETV6
17 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.52 MYB
18 Increased shRNA abundance (Z-score > 2) GR00366-A-164 10.52 MYB
19 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.52 MYB
20 Increased shRNA abundance (Z-score > 2) GR00366-A-176 10.52 ETV6 MPO
21 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.52 MYB
22 Increased shRNA abundance (Z-score > 2) GR00366-A-186 10.52 MPO
23 Increased shRNA abundance (Z-score > 2) GR00366-A-198 10.52 ETV6
24 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.52 ETV6
25 Increased shRNA abundance (Z-score > 2) GR00366-A-215 10.52 CSF2RA
26 Increased shRNA abundance (Z-score > 2) GR00366-A-23 10.52 CSF2RA
27 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.52 MPO
28 Increased shRNA abundance (Z-score > 2) GR00366-A-32 10.52 CSF2RA
29 Increased shRNA abundance (Z-score > 2) GR00366-A-36 10.52 MPO
30 Increased shRNA abundance (Z-score > 2) GR00366-A-50 10.52 CSF2RA
31 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.52 ETV6
32 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.52 MPO
33 Increased shRNA abundance (Z-score > 2) GR00366-A-65 10.52 CSF2RA MYB
34 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.52 MPO
35 Increased shRNA abundance (Z-score > 2) GR00366-A-70 10.52 MPO
36 Increased shRNA abundance (Z-score > 2) GR00366-A-73 10.52 CSF2RA ETV6 MYB
37 Increased shRNA abundance (Z-score > 2) GR00366-A-83 10.52 MYB
38 Increased shRNA abundance (Z-score > 2) GR00366-A-96 10.52 CSF2RA
39 Reduced mammosphere formation GR00396-S 9.02 CSF2RA ETV6 GATA1 IL18R1 IL3RA

MGI Mouse Phenotypes related to Acute Basophilic Leukemia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 ETV6 GATA1 IL18R1 IL3RA MPO MYB
2 immune system MP:0005387 9.1 ETV6 GATA1 IL18R1 IL3RA MPO MYB

Drugs & Therapeutics for Acute Basophilic Leukemia

Search Clinical Trials , NIH Clinical Center for Acute Basophilic Leukemia

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Genetic Tests for Acute Basophilic Leukemia

Anatomical Context for Acute Basophilic Leukemia

MalaCards organs/tissues related to Acute Basophilic Leukemia:

42
Myeloid, Bone, Bone Marrow, Liver, Testes, T Cells

Publications for Acute Basophilic Leukemia

Articles related to Acute Basophilic Leukemia:

(show all 31)
# Title Authors Year
1
Acute basophilic leukemia with U2AF1 mutation. ( 30827760 )
2019
2
Acute basophilic leukemia with add(3)(q12) accompanied by histamine excess symptoms. ( 28424883 )
2017
3
Acute basophilic leukemia associated with the t(16;21)(p11;q22)/FUS-ERG fusion gene. ( 29225830 )
2017
4
Acute basophilic leukemia. ( 24949509 )
2014
5
Acute basophilic leukemia presenting with maculopapular rashes and a gastric ulcer: A case report. ( 25364419 )
2014
6
A case of Langerhans cell histiocytosis following acute basophilic leukemia. ( 22895553 )
2013
7
Arsenic trioxide in treatment of de novo acute basophilic leukemia. ( 23422134 )
2013
8
Acute basophilic leukemia in an infant with proptosis. ( 21393925 )
2011
9
Identification of a transforming MYB-GATA1 fusion gene in acute basophilic leukemia: a new entity in male infants. ( 21474671 )
2011
10
Acute basophilic leukemia associated with loss of gene ETV6 and protean complications. ( 21576634 )
2011
11
Trisomy 19 and t(9;22) in a patient with acute basophilic leukemia. ( 22937382 )
2011
12
A case of acute basophilic leukemia arising from chronic myelogenous leukemia with development of t(7;8)(q32;q13). ( 18328951 )
2008
13
Monosomy 7 as the sole abnormality of an acute basophilic leukemia. ( 17213028 )
2007
14
Imatinib resistant chronic myelogenous leukemia, BCR-ABL positive by chromosome and FISH analyses but negative by PCR, in a child progressing to acute basophilic leukemia: cytogenetic follow-up. ( 16965955 )
2006
15
Acute basophilic leukemia with t(8;21). ( 15160925 )
2004
16
Acute basophilic leukemia: case report. ( 15164378 )
2004
17
Acute basophilic leukemia lacking basophil-specific antigens: the importance of cytokine receptor expression in differential diagnosis. ( 11999362 )
2002
18
Acute basophilic leukemia. ( 11722593 )
2001
19
Acute basophilic leukemia presenting with abnormal liver function tests and the absence of blast cells in the peripheral blood. ( 10740808 )
2000
20
Diagnosis of acute basophilic leukemia. ( 10037024 )
1999
21
Acute basophilic leukemia in a child. Anaphylactoid reaction and coagulopathy secondary to vincristine-mediated degranulation. ( 7804964 )
1995
22
An abnormal clone with monosomy 7 and trisomy 21 in the bone marrow of a child with congenital agranulocytosis (Kostmann disease) treated with granulocyte colony-stimulating factor. Evolution towards myelodysplastic syndrome and acute basophilic leukemia. ( 8536230 )
1995
23
Acute basophilic leukemia and acute eosinophilic leukemia after therapy for non-Hodgkin's lymphoma. ( 8257517 )
1993
24
[Acute basophilic leukemia: a case report]. ( 7689662 )
1993
25
Acute basophilic leukemia. ( 1489389 )
1992
26
Acute basophilic leukemia. A case report. ( 1718580 )
1991
27
Evolution of the French-American-British (FAB) proposals. Is there a place for acute basophilic leukemia? ( 1862770 )
1991
28
Acute basophilic leukemia. A clinical, morphologic, and cytogenetic study of eight cases. ( 1862771 )
1991
29
Acute basophilic leukemia. ( 6731465 )
1984
30
Follow-up of sixty two cases of acute basophilic leukemia. ( 667277 )
1978
31
Mast cell leukemia and acute basophilic leukemia. Cytochemical studies. ( 747630 )
1978

Variations for Acute Basophilic Leukemia

Expression for Acute Basophilic Leukemia

Search GEO for disease gene expression data for Acute Basophilic Leukemia.

Pathways for Acute Basophilic Leukemia

GO Terms for Acute Basophilic Leukemia

Biological processes related to Acute Basophilic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of hematopoietic stem cell differentiation GO:1902036 8.62 GATA1 MYB

Molecular functions related to Acute Basophilic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.33 ETV6 GATA1 MYB
2 cytokine binding GO:0019955 8.96 CSF2RA IL3RA
3 cytokine receptor activity GO:0004896 8.62 CSF2RA IL3RA

Sources for Acute Basophilic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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