MCID: ACT241
MIFTS: 29

Acute Bilirubin Encephalopathy

Categories: Metabolic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Acute Bilirubin Encephalopathy

MalaCards integrated aliases for Acute Bilirubin Encephalopathy:

Name: Acute Bilirubin Encephalopathy 60
Acute Kernicterus 60
Abe 60

Classifications:



Summaries for Acute Bilirubin Encephalopathy

MalaCards based summary : Acute Bilirubin Encephalopathy, also known as acute kernicterus, is related to gm2-gangliosidosis, ab variant and thymoma type ab. Affiliated tissues include thyroid, prostate and t cells, and related phenotypes are prolonged neonatal jaundice and neonatal hyperbilirubinemia

Related Diseases for Acute Bilirubin Encephalopathy

Diseases in the Acute Bilirubin Encephalopathy family:

Chronic Bilirubin Encephalopathy

Diseases related to Acute Bilirubin Encephalopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 309)
# Related Disease Score Top Affiliating Genes
1 gm2-gangliosidosis, ab variant 12.8
2 thymoma type ab 12.2
3 malignant type ab thymoma 12.1
4 gm2-gangliosidosis, b, b1, ab variant 12.1
5 constricting bands, congenital 11.5
6 antley-bixler syndrome with genital anomalies and disordered steroidogenesis 11.3
7 antley-bixler syndrome without genital anomalies or disordered steroidogenesis 11.3
8 anemia, sideroblastic, 4 11.1
9 macs syndrome 11.1
10 tay-sachs disease 11.1
11 mixed type thymoma 11.1
12 fraser jequier chen syndrome 11.1
13 kernicterus 10.5
14 encephalopathy 10.5
15 open-angle glaucoma 10.4
16 blood group, gerbich system 10.3
17 gm2 gangliosidosis 10.3
18 gangliosidosis 10.3
19 horns in sheep 10.3
20 thymoma, familial 10.3
21 thymoma 10.3
22 cataract 10.2
23 glaucoma, primary open angle 10.2
24 retinoblastoma 10.2
25 allergic encephalomyelitis 10.2
26 syphilis 10.1
27 hepatitis 10.1
28 thyroid cancer 10.1
29 streptococcal group a invasive disease 10.1
30 isolated optic neuritis 10.1
31 melanoma 10.1
32 encephalitis 10.1
33 carney complex, type 1 10.0
34 prostate cancer 10.0
35 triiodothyronine receptor auxiliary protein 10.0
36 prostate cancer, hereditary, 8 10.0
37 caronte 10.0
38 prostate cancer, hereditary, 6 10.0
39 human immunodeficiency virus infectious disease 10.0
40 glaucoma 3, primary congenital, a 10.0
41 myasthenia gravis 10.0
42 glaucoma 3, primary infantile, b 10.0
43 malaria 10.0
44 thrombocytopenia 10.0
45 primary congenital glaucoma 10.0
46 squamous cell carcinoma 10.0
47 amelanotic melanoma 10.0
48 myasthenia gravis congenital 10.0
49 rheumatoid arthritis 9.9
50 cystic fibrosis 9.9

Graphical network of the top 20 diseases related to Acute Bilirubin Encephalopathy:



Diseases related to Acute Bilirubin Encephalopathy

Symptoms & Phenotypes for Acute Bilirubin Encephalopathy

Human phenotypes related to Acute Bilirubin Encephalopathy:

60 33 (show all 20)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 prolonged neonatal jaundice 60 33 hallmark (90%) Very frequent (99-80%) HP:0006579
2 neonatal hyperbilirubinemia 60 33 hallmark (90%) Very frequent (99-80%) HP:0003265
3 abnormal auditory evoked potentials 60 33 hallmark (90%) Very frequent (99-80%) HP:0006958
4 hepatic encephalopathy 60 33 hallmark (90%) Very frequent (99-80%) HP:0002480
5 seizures 60 33 frequent (33%) Frequent (79-30%) HP:0001250
6 sensorineural hearing impairment 60 33 frequent (33%) Frequent (79-30%) HP:0000407
7 hypertonia 60 33 frequent (33%) Frequent (79-30%) HP:0001276
8 fever 60 33 frequent (33%) Frequent (79-30%) HP:0001945
9 hemolytic anemia 60 33 frequent (33%) Frequent (79-30%) HP:0001878
10 feeding difficulties 60 33 frequent (33%) Frequent (79-30%) HP:0011968
11 cerebral palsy 60 33 frequent (33%) Frequent (79-30%) HP:0100021
12 central apnea 60 33 frequent (33%) Frequent (79-30%) HP:0002871
13 hypoalbuminemia 60 33 frequent (33%) Frequent (79-30%) HP:0003073
14 abnormal thalamic mri signal intensity 60 33 frequent (33%) Frequent (79-30%) HP:0012696
15 kernicterus 60 33 frequent (33%) Frequent (79-30%) HP:0001343
16 conjunctival icterus 60 33 frequent (33%) Frequent (79-30%) HP:0032106
17 neonatal sepsis 60 33 occasional (7.5%) Occasional (29-5%) HP:0040187
18 hypernatremia 60 33 occasional (7.5%) Occasional (29-5%) HP:0003228
19 upgaze palsy 60 33 occasional (7.5%) Occasional (29-5%) HP:0025331
20 abnormal conjunctiva morphology 60 Frequent (79-30%)

Drugs & Therapeutics for Acute Bilirubin Encephalopathy

Search Clinical Trials , NIH Clinical Center for Acute Bilirubin Encephalopathy

Genetic Tests for Acute Bilirubin Encephalopathy

Anatomical Context for Acute Bilirubin Encephalopathy

MalaCards organs/tissues related to Acute Bilirubin Encephalopathy:

42
Thyroid, Prostate, T Cells, Bone, Eye, Breast, Globus Pallidus

Publications for Acute Bilirubin Encephalopathy

Articles related to Acute Bilirubin Encephalopathy:

(show all 17)
# Title Authors Year
1
Characteristics and outcome of newborn admitted with acute bilirubin encephalopathy to a tertiary neonatal intensive care unit. ( 30406356 )
2019
2
The Neonatal Acute Bilirubin Encephalopathy Registry (NABER): Background, Aims, and Protocol. ( 30669144 )
2019
3
Patterns of acute bilirubin encephalopathy in Nigeria: a multicenter pre-intervention study. ( 29593357 )
2018
4
Extreme neonatal hyperbilirubinemia, acute bilirubin encephalopathy, and kernicterus spectrum disorder in children with galactosemia. ( 29892033 )
2018
5
Emergency release uncross-matched packed red blood cells for immediate double volume exchange transfusion in neonates with intermediate to advanced acute bilirubin encephalopathy: timely but insufficient? ( 29997396 )
2018
6
Magnetic Resonance Imaging Abnormalities in Advanced Acute Bilirubin Encephalopathy Highlight Dentato-Thalamo-Cortical Pathways. ( 27113379 )
2016
7
Risk factors for acute bilirubin encephalopathy on admission to two Myanmar national paediatric hospitals. ( 27057339 )
2015
8
Apnea in acute bilirubin encephalopathy. ( 25239473 )
2014
9
Acute kernicterus in a neonate with O/B blood group incompatibility and a mutation in SLC4A1. ( 23878048 )
2013
10
Predictors of acute bilirubin encephalopathy among Nigerian term babies with moderate-to-severe hyperbilirubinaemia. ( 20554515 )
2011
11
The kernicteric facies: facial features of acute bilirubin encephalopathy. ( 21215919 )
2011
12
Prevention of acute bilirubin encephalopathy and kernicterus in newborns: position statement #3049. ( 22123452 )
2011
13
Neurodevelopmental outcome of acute bilirubin encephalopathy. ( 20123952 )
2010
14
Prevention of acute bilirubin encephalopathy and kernicterus in newborns. Position Statement #3049. NANN Board of Directors, March 2010. ( 20505419 )
2010
15
Hyperintense globus pallidus on T1-weighted MR imaging in acute kernicterus: is it common or rare? ( 15565320 )
2005
16
Acute bilirubin encephalopathy induced with sulfadimethoxine in Gunn rats. ( 263615 )
1979
17
Electron microscopic observations on acute bilirubin encephalopathy in Gunn rats induced by sulfadimethoxine. ( 4322704 )
1971

Variations for Acute Bilirubin Encephalopathy

Expression for Acute Bilirubin Encephalopathy

Search GEO for disease gene expression data for Acute Bilirubin Encephalopathy.

Pathways for Acute Bilirubin Encephalopathy

GO Terms for Acute Bilirubin Encephalopathy

Sources for Acute Bilirubin Encephalopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
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20 FMA
29 GO
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35 ICD10 via Orphanet
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46 MESH via Orphanet
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50 NCI
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52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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