MCID: ACT066
MIFTS: 32

Acute Cervicitis

Categories: Reproductive diseases

Aliases & Classifications for Acute Cervicitis

MalaCards integrated aliases for Acute Cervicitis:

Name: Acute Cervicitis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10616
NCIt 50 C27056
SNOMED-CT 68 19272000
UMLS 73 C0269061

Summaries for Acute Cervicitis

Disease Ontology : 12 A cervicitis that is characterized by onset within the past 1 - 3 days.

MalaCards based summary : Acute Cervicitis is related to cervicitis and acute gonococcal cervicitis. An important gene associated with Acute Cervicitis is MT-TG (Mitochondrially Encoded TRNA Glycine), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Affiliated tissues include lung, bone and spinal cord, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Acute Cervicitis

Diseases in the Cervicitis family:

Acute Cervicitis Chronic Cervicitis

Diseases related to Acute Cervicitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 cervicitis 30.0 MT-TG SERPIND1
2 acute gonococcal cervicitis 11.0
3 neurosyphilis 10.2 CXCL10 TLR2
4 spinal cord injury 10.1
5 endocervicitis 10.1 MT-TG TLR4
6 spotted fever 10.1 CCL5 CXCL10
7 autoimmune peripheral neuropathy 10.1 CD86 CXCL10
8 viral meningitis 10.1 CCL5 CXCL10
9 prosthetic joint infection 10.1 TLR2 TLR4
10 trench fever 10.1 TLR2 TLR4
11 fungal keratitis 10.1 TLR2 TLR4
12 anterior uveitis 10.1 TLR2 TLR4
13 suppurative otitis media 10.1 TLR2 TLR4
14 spondylarthropathy 10.1 TLR2 TLR4
15 neisseria meningitidis infection 10.1 TLR2 TLR4
16 genital herpes 10.1 CCL5 TLR2
17 alveolar echinococcosis 10.1 TLR2 TLR4
18 echinococcosis 10.1 TLR2 TLR4
19 septic arthritis 10.1 TLR2 TLR4
20 japanese encephalitis 10.1 CCL5 CXCL10
21 scrub typhus 10.1 TLR2 TLR4
22 irak4 deficiency 10.1 TLR2 TLR4
23 myd88 deficiency 10.0 TLR2 TLR4
24 middle ear disease 10.0 TLR2 TLR4
25 pelvic inflammatory disease 10.0 TLR2 TLR4
26 viral encephalitis 10.0 CCL5 CXCL10
27 pulmonary disease, chronic obstructive 10.0 CCL5 CXCL10 TLR2
28 japanese spotted fever 10.0 CCL4 CXCL10
29 invasive aspergillosis 10.0 CXCL10 TLR2 TLR4
30 q fever 10.0 TLR2 TLR4
31 primary bacterial infectious disease 10.0 CXCL10 TLR2 TLR4
32 mycobacterium tuberculosis 1 10.0 CXCL10 TLR2 TLR4
33 omsk hemorrhagic fever 10.0 CCL4 CCL5
34 penicilliosis 10.0 CD86 TLR2 TLR4
35 myositis fibrosa 10.0 CD86 TLR2 TLR4
36 whiplash 10.0 CCL4 CCL5
37 glaucomatocyclitic crisis 10.0 CCL4 CXCL10
38 filariasis 10.0 CCL5 TLR2 TLR4
39 cervical adenitis 10.0
40 chronic nk-cell lymphocytosis 9.9 CCL4 CCL5
41 stachybotrys chartarum 9.9 CCL4 CCL5
42 eosinophilic pneumonia 9.9 CCL5 CSF2
43 pulmonary sarcoidosis 9.9 CCL5 CSF2 CXCL5
44 keratitis, hereditary 9.9 CXCL1 TLR2 TLR4
45 idiopathic neutropenia 9.9 CCL5 TLR4
46 bacterial vaginosis 9.9 TLR2 TLR4
47 lymphadenitis 9.9
48 mastitis 9.9 CCL5 CSF2 TLR2
49 ileitis 9.9 CSF2 TLR2 TLR4
50 aspergillosis 9.9 CSF2 TLR2 TLR4

Graphical network of the top 20 diseases related to Acute Cervicitis:



Diseases related to Acute Cervicitis

Symptoms & Phenotypes for Acute Cervicitis

GenomeRNAi Phenotypes related to Acute Cervicitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00231-A 9.02 CCL4 CXCL10
2 Decreased viability GR00342-S-3 9.02 CCL4
3 Decreased viability GR00402-S-2 9.02 CCL4 CXCL10

MGI Mouse Phenotypes related to Acute Cervicitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.17 CCL5 CD86 CSF2 CXCL10 SERPIND1 TLR2

Drugs & Therapeutics for Acute Cervicitis

Search Clinical Trials , NIH Clinical Center for Acute Cervicitis

Genetic Tests for Acute Cervicitis

Anatomical Context for Acute Cervicitis

MalaCards organs/tissues related to Acute Cervicitis:

41
Lung, Bone, Spinal Cord, Nk Cells

Publications for Acute Cervicitis

Articles related to Acute Cervicitis:

# Title Authors Year
1
Identifying acute cervicitis in an era of less-frequent routine gynecologic examinations. ( 29369931 )
2018
2
Acute cervicitis and vulvovaginitis may be associated with Cytomegalovirus. ( 23606387 )
2013
3
The copper-7 device in chronic and IUD-induced acute cervicitis treated with oral estriol. ( 4614936 )
1974

Variations for Acute Cervicitis

Expression for Acute Cervicitis

Search GEO for disease gene expression data for Acute Cervicitis.

Pathways for Acute Cervicitis

Pathways related to Acute Cervicitis according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.82 CCL4 CCL5 CD86 CSF2 CXCL1 CXCL10
2
Show member pathways
13.48 CCL4 CCL5 CSF2 CXCL1 CXCL10 CXCL5
3
Show member pathways
13.23 CCL4 CCL5 CSF2 CXCL1 CXCL10 CXCL5
4
Show member pathways
13.18 CCL4 CCL5 CXCL1 CXCL10 CXCL5
5
Show member pathways
13.17 CCL4 CCL5 CD86 CSF2 CXCL1 CXCL10
6
Show member pathways
13.12 CCL4 CCL5 CSF2 CXCL1 CXCL10 CXCL5
7
Show member pathways
12.89 CCL4 CCL5 CD86 CSF2 CXCL1 TLR2
8
Show member pathways
12.83 CCL4 CCL5 CD86 CXCL1 CXCL10 TLR2
9
Show member pathways
12.71 CCL4 CCL5 CXCL1 CXCL10 CXCL5
10
Show member pathways
12.62 CCL5 CXCL10 TLR2 TLR4
11
Show member pathways
12.59 CCL4 CCL5 CXCL10 TLR4
12
Show member pathways
12.23 CSF2 CXCL1 CXCL10 CXCL5 TLR2
13
Show member pathways
12.03 CXCL10 TLR2 TLR4
14
Show member pathways
12.02 CCL4 CCL5 CXCL1 CXCL10 CXCL5 TLR2
15
Show member pathways
11.91 CD86 TLR2 TLR4
16
Show member pathways
11.89 CSF2 TLR2 TLR4
17
Show member pathways
11.87 CCL4 CCL5 CXCL1 CXCL10 CXCL5
18 11.86 CXCL1 CXCL10 TLR4
19 11.82 CSF2 CXCL1 TLR2 TLR4
20 11.76 CCL5 CSF2 CXCL1 CXCL10 CXCL5
21 11.75 CCL4 CSF2 CXCL1 TLR4
22
Show member pathways
11.74 CSF2 CXCL1 TLR4
23 11.54 CCL4 CCL5 CSF2
24 11.48 CCL4 CCL5 CD86 CSF2 CXCL1 CXCL10
25 11.46 CXCL1 TLR2 TLR4
26 11.12 CCL4 CCL5 CD86 CSF2 CXCL1 CXCL10
27 11.12 CCL5 CD86 CSF2 CXCL1 CXCL5 TLR2
28 11.1 CSF2 CXCL1
29 10.96 CCL4 CCL5 CSF2 CXCL1 CXCL10 CXCL5
30 10.9 CCL4 CCL5 CSF2 CXCL1 CXCL10 CXCL5

GO Terms for Acute Cervicitis

Cellular components related to Acute Cervicitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 CCL4 CCL5 CSF2 CXCL1 CXCL10 CXCL5
2 extracellular space GO:0005615 9.17 CCL4 CCL5 CSF2 CXCL1 CXCL10 CXCL5
3 intrinsic component of plasma membrane GO:0031226 9.16 TLR2 TLR4

Biological processes related to Acute Cervicitis according to GeneCards Suite gene sharing:

(show all 43)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.97 CD86 CSF2 CXCL10 CXCL5
2 regulation of signaling receptor activity GO:0010469 9.91 CCL4 CCL5 CSF2 CXCL1 CXCL10 CXCL5
3 cytokine-mediated signaling pathway GO:0019221 9.88 CCL4 CCL5 CD86 CSF2 CXCL1 CXCL10
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.86 CCL4 CCL5 TLR4
5 response to lipopolysaccharide GO:0032496 9.83 CXCL10 TLR2 TLR4
6 cell-cell signaling GO:0007267 9.83 CCL4 CCL5 CXCL10 CXCL5
7 defense response GO:0006952 9.81 CXCL1 CXCL10 CXCL5
8 inflammatory response GO:0006954 9.8 CCL4 CCL5 CXCL1 CXCL10 CXCL5 TLR2
9 response to virus GO:0009615 9.79 CCL4 CCL5 CXCL10
10 neutrophil chemotaxis GO:0030593 9.77 CCL4 CCL5 CXCL1 CXCL10 CXCL5
11 response to toxic substance GO:0009636 9.76 CCL4 CCL5 TLR2
12 cellular response to interferon-gamma GO:0071346 9.76 CCL4 CCL5 TLR2 TLR4
13 cell chemotaxis GO:0060326 9.74 CCL5 CXCL10 CXCL5
14 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.72 CXCL1 CXCL10 CXCL5
15 chemokine-mediated signaling pathway GO:0070098 9.72 CCL4 CCL5 CXCL1 CXCL10 CXCL5
16 monocyte chemotaxis GO:0002548 9.69 CCL4 CCL5
17 lipopolysaccharide-mediated signaling pathway GO:0031663 9.69 CCL5 TLR2 TLR4
18 toll-like receptor signaling pathway GO:0002224 9.68 TLR2 TLR4
19 lymphocyte chemotaxis GO:0048247 9.68 CCL4 CCL5
20 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.68 TLR2 TLR4
21 positive regulation of interleukin-8 production GO:0032757 9.67 TLR2 TLR4
22 positive regulation of interferon-beta production GO:0032728 9.67 TLR2 TLR4
23 positive regulation of calcium ion transport GO:0051928 9.66 CCL4 CCL5
24 positive regulation of interleukin-12 production GO:0032735 9.66 TLR2 TLR4
25 positive regulation of interleukin-10 production GO:0032733 9.65 TLR2 TLR4
26 eosinophil chemotaxis GO:0048245 9.65 CCL4 CCL5
27 leukocyte chemotaxis GO:0030595 9.65 CXCL1 CXCL10 CXCL5
28 positive regulation of chemokine production GO:0032722 9.64 TLR2 TLR4
29 positive regulation of monocyte chemotaxis GO:0090026 9.63 CCL5 CXCL10
30 positive regulation of T cell migration GO:2000406 9.63 CCL5 CXCL10
31 cellular response to lipopolysaccharide GO:0071222 9.63 CD86 CSF2 CXCL1 CXCL10 CXCL5 TLR4
32 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.62 TLR2 TLR4
33 regulation of cytokine secretion GO:0050707 9.62 TLR2 TLR4
34 I-kappaB phosphorylation GO:0007252 9.61 TLR2 TLR4
35 negative regulation by host of viral transcription GO:0043922 9.6 CCL4 CCL5
36 macrophage activation GO:0042116 9.59 CSF2 TLR4
37 cellular response to lipoteichoic acid GO:0071223 9.58 TLR2 TLR4
38 positive regulation of natural killer cell chemotaxis GO:2000503 9.56 CCL4 CCL5
39 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.49 TLR2 TLR4
40 chemotaxis GO:0006935 9.43 CCL4 CCL5 CXCL1 CXCL10 CXCL5 SERPIND1
41 immune response GO:0006955 9.28 CCL4 CCL5 CD86 CSF2 CXCL1 CXCL10
42 signal transduction GO:0007165 10.08 CCL4 CD86 CXCL1 CXCL10 CXCL5 TLR2
43 G protein-coupled receptor signaling pathway GO:0007186 10.07 CCL4 CCL5 CXCL1 CXCL10 CXCL5

Molecular functions related to Acute Cervicitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.77 CCL4 CCL5 CXCL5 TLR2 TLR4
2 signaling receptor activity GO:0038023 9.63 CD86 TLR2 TLR4
3 lipopolysaccharide binding GO:0001530 9.43 TLR2 TLR4
4 CCR chemokine receptor binding GO:0048020 9.4 CCL4 CCL5
5 cytokine activity GO:0005125 9.35 CCL4 CCL5 CSF2 CXCL1 CXCL10
6 CCR5 chemokine receptor binding GO:0031730 9.32 CCL4 CCL5
7 CCR1 chemokine receptor binding GO:0031726 9.26 CCL4 CCL5
8 lipopolysaccharide receptor activity GO:0001875 9.16 TLR2 TLR4
9 chemokine activity GO:0008009 9.02 CCL4 CCL5 CXCL1 CXCL10 CXCL5

Sources for Acute Cervicitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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