MCID: ACT066
MIFTS: 30

Acute Cervicitis

Categories: Reproductive diseases

Aliases & Classifications for Acute Cervicitis

MalaCards integrated aliases for Acute Cervicitis:

Name: Acute Cervicitis 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:10616
NCIt 50 C27056
SNOMED-CT 67 19272000
UMLS 70 C0269061

Summaries for Acute Cervicitis

Disease Ontology : 12 A cervicitis that is characterized by onset within the past 1 - 3 days.

MalaCards based summary : Acute Cervicitis is related to acute gonococcal cervicitis and cervicitis. An important gene associated with Acute Cervicitis is SCARF1 (Scavenger Receptor Class F Member 1), and among its related pathways/superpathways are NF-kappaB Signaling and Diseases associated with the TLR signaling cascade. The drugs Cyclobenzaprine and Psychotropic Drugs have been mentioned in the context of this disorder. Affiliated tissues include spinal cord and cervix, and related phenotype is hematopoietic system.

Related Diseases for Acute Cervicitis

Diseases in the Cervicitis family:

Acute Cervicitis Chronic Cervicitis

Diseases related to Acute Cervicitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 179)
# Related Disease Score Top Affiliating Genes
1 acute gonococcal cervicitis 30.4 SCARF1 LY96 IL10 CXCL8 CEACAM1 ASGR1
2 cervicitis 30.2 SERPIND1 IL10 CXCL8
3 vaginal discharge 30.0 IL10 CXCL8
4 vulvovaginitis 30.0 IL10 CXCL8
5 endometritis 29.7 TLR2 CXCL8
6 genital herpes 29.7 TLR2 IL10
7 enterocolitis 10.1 IL10 CXCL8
8 myelitis 10.1 IL10 CXCL8
9 acute transverse myelitis 10.1 IL10 CXCL8
10 transverse myelitis 10.1 IL10 CXCL8
11 bacterial conjunctivitis 10.1 IL10 CXCL8
12 progressive myoclonus epilepsy 8 10.1 IL10 CXCL8
13 mycetoma 10.1 IL10 CXCL8
14 primary peritoneal carcinoma 10.1 IL10 CXCL8
15 mansonelliasis 10.1 IL10 CXCL8
16 tungiasis 10.1 IL10 CXCL8
17 scabies 10.1 IL10 CXCL8
18 trichomoniasis 10.1 IL10 CXCL8
19 clonorchiasis 10.1 IL10 CXCL8
20 cardiomyopathy, familial hypertrophic, 20 10.1 IL10 CXCL8
21 fungal meningitis 10.1 IL10 CXCL8
22 juvenile arthritis 10.1 IL10 CXCL8
23 funisitis 10.1 IL10 CXCL8
24 chronic conjunctivitis 10.1 IL10 CXCL8
25 cecal disease 10.1 IL10 CXCL8
26 viral pneumonia 10.1 IL10 CXCL8
27 bronchopneumonia 10.1 IL10 CXCL8
28 drug-induced lupus erythematosus 10.1 IL10 CXCL8
29 relapsing polychondritis 10.1 IL10 CXCL8
30 lichen disease 10.1 IL10 CXCL8
31 urethral syndrome 10.1 CXCL8 CEACAM1
32 status asthmaticus 10.1 IL10 CXCL8
33 lacrimal apparatus disease 10.1 IL10 CXCL8
34 acute pyelonephritis 10.1 IL10 CXCL8
35 radiculopathy 10.1 IL10 CXCL8
36 retinal artery occlusion 10.1 IL10 CXCL8
37 conjunctival disease 10.1 IL10 CXCL8
38 dysentery 10.1 IL10 CXCL8
39 helicobacter pylori infection 10.1 IL10 CXCL8
40 churg-strauss syndrome 10.0 IL10 CXCL8
41 erythema nodosum 10.0 IL10 CXCL8
42 coronavirus infectious disease 10.0 IL10 CXCL8
43 autoimmune disease of cardiovascular system 10.0 IL10 CXCL8
44 dermatitis herpetiformis 10.0 IL10 CXCL8
45 viral encephalitis 10.0 IL10 CXCL8
46 complex regional pain syndrome 10.0 IL10 CXCL8
47 aseptic meningitis 10.0 IL10 CXCL8
48 nasal cavity disease 10.0 IL10 CXCL8
49 paranasal sinus disease 10.0 IL10 CXCL8
50 allergic conjunctivitis 10.0 IL10 CXCL8

Graphical network of the top 20 diseases related to Acute Cervicitis:



Diseases related to Acute Cervicitis

Symptoms & Phenotypes for Acute Cervicitis

MGI Mouse Phenotypes related to Acute Cervicitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.17 ASGR1 CEACAM1 IL10 LY96 SCARF1 SERPIND1

Drugs & Therapeutics for Acute Cervicitis

Drugs for Acute Cervicitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclobenzaprine Approved Phase 3 303-53-7 2895
2 Psychotropic Drugs Phase 3
3 Antidepressive Agents Phase 3
4 Antidepressive Agents, Tricyclic Phase 3
5
Amitriptyline Approved Phase 2 50-48-6 2160
6
Ibuprofen Approved Phase 2 15687-27-1 3672
7 Neurotransmitter Agents Phase 2
8 Analgesics, Non-Narcotic Phase 2
9 Analgesics Phase 2
10 Amitriptyline, perphenazine drug combination Phase 2
11 Cyclooxygenase Inhibitors Phase 2
12 Antirheumatic Agents Phase 2
13 Adrenergic Agents Phase 2
14 Anti-Inflammatory Agents Phase 2
15 Anti-Inflammatory Agents, Non-Steroidal Phase 2
16 Imatinib Mesylate Phase 2 220127-57-1 123596
17 Protein Kinase Inhibitors Phase 2
18 Vasoconstrictor Agents

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Multicenter Trial to Study the Efficacy and Safety of Cyclobenzaprine HCl Extended Release (CER) 15 mg in Subjects With Acute Cervical and/or Lower Back Pain Due to Muscle Spasms of Local Origin Completed NCT02814565 Phase 3 Cyclobenzaprine HCl;Placebo
2 A Phase II/III, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study to Assess the Efficacy and Safety of Cethrin in Subjects With Acute Cervical Spinal Cord Injury Withdrawn NCT02053883 Phase 2, Phase 3 Cethrin (BA-210);Placebo
3 Transcranial Electrical Stimulation for Management of Orthostatic Instability in Acute Cervical Spinal Cord Injury Completed NCT01874782 Phase 2
4 Comparison of Ibuprofen, Cyclobenzaprine, or Both for Acute Cervical Strain: A Randomized Clinical Trial Completed NCT00790270 Phase 2 Cyclobenzaprine;Ibuprofen;Ibuprofen plus Cyclobenzaprine
5 Treatment of Acute Cervical Spinal Cord Injury With Imatinib (Glivec®) - a Safety and Feasibility Study (EudraCT no 2014-002170-36) Not yet recruiting NCT02363361 Phase 2 Imatinib
6 A Phase IIb, Double-Blind, Randomized, Placebo Controlled, Multicenter Study to Assess the Safety and Efficacy of Intraoperative Epidural Cethrin® in Adult Subjects With Acute Cervical Spinal Cord Injury Withdrawn NCT00610337 Phase 2 Cethrin® (BA-210)
7 Effect of Two Different Air-stacking Techniques, Combined With Manually Assisted Cough, on Peak Cough Flow (PCF) in Patients With Acute Cervical or High Thoracic Spinal Cord Injury Withdrawn NCT01046175 Phase 2
8 A Randomised Controlled Trial of Multimodal Physiotherapy for Patients With Acute / Sub-acute Cervical Radiculopathy Unknown status NCT02449200
9 A Comparison of High vs. Low Tidal Volumes in Ventilator Weaning for Individuals With Sub-Acute Cervical Spinal Cord Injuries Completed NCT00412308
10 Medical Imaging Characteristics of Patient With Unclassified Acute Cervical Pain Completed NCT03690882
11 No Difference in Gait Pattern Between a Cemented and Non-cemented Femur Stem. 45 Prospective Randomized Total Hip Arthroplasty Patients After Acute Cervical Femur Fracture Evaluated After 2 Years Completed NCT04791605
12 The Effectiveness of Manipulation Treatment in Acute Cervical Region Pain Recruiting NCT04455048
13 Systemic Hypothermia in Acute Cervical Spinal Cord Injury - A Prospective, Multi-center Case Controlled Study Recruiting NCT02991690
14 Characterizing Hemorrhage in Acute Spinal Cord Injury With MRI Not yet recruiting NCT04758377
15 Diffusion Tensor MRI to Assess Subacute Functional Outcomes in Patients With Acute Cervical Spinal Cord Injuries Withdrawn NCT01712698

Search NIH Clinical Center for Acute Cervicitis

Genetic Tests for Acute Cervicitis

Anatomical Context for Acute Cervicitis

MalaCards organs/tissues related to Acute Cervicitis:

40
Spinal Cord, Cervix

Publications for Acute Cervicitis

Articles related to Acute Cervicitis:

(show all 25)
# Title Authors PMID Year
1
Comparison of the AV Magnivisualizer device with colposcopy to detect cervical intraepithelial neoplasia using the Swede scoring system. 61
31353466 2019
2
National Institute of Allergy and Infectious Diseases workshop report: "Chlamydia vaccines: The way forward". 61
29097007 2019
3
New serum biomarker identification and analysis by mass spectrometry in cervical precancerous lesion and acute cervicitis in South China. 61
31308751 2019
4
Identifying acute cervicitis in an era of less-frequent routine gynecologic examinations. 61
29369931 2018
5
Cytopathological Examination and Epidemiological Study of Cervicitis in Commercial Sex Workers (CSWs) in Coal City (Enugu), Nigeria. 61
26633925 2015
6
Underrecognition of cervical Neisseria gonorrhoeae and Chlamydia trachomatis infections in pregnant patients in the ED. 61
23391639 2013
7
Acute cervicitis and vulvovaginitis may be associated with Cytomegalovirus. 61
23606387 2013
8
Flavonoid naringenin: a potential immunomodulator for Chlamydia trachomatis inflammation. 61
23766556 2013
9
A cyto-epidemiological study on married women in reproductive age group (15-49 years) regarding reproductive tract infection in a rural community of West Bengal. 61
23229212 2012
10
Prevention of infection after induced abortion: release date October 2010: SFP guideline 20102. 61
21397086 2011
11
Duration of untreated chlamydial genital infection and factors associated with clearance: review of animal studies. 61
20470047 2010
12
Early detection of precursors of cervical cancer with cervical cytology and visual inspection of cervix with acetic Acid. 61
18709035 2008
13
Non-neoplastic diseases of the cervix in Nigerians: a histopathological study. 61
16916295 2006
14
Noncorrelating Pap tests and cervical biopsies: histological predictors of subsequent correlation. 61
15830356 2005
15
[Preliminary study on the relationship between loads of human papillomavirus in cervical carcinoma and cervical intraepithelial neoplasia]. 61
15312325 2004
16
Natural history of cervical intraepithelial neoplasia 1 in primigravida. 61
17051041 2003
17
Evaluation of a new instrument designed for directed cervical excision: cone biopsy excisor. 61
25951355 1998
18
[Vaginal parasites and acute cervicitis: local treatment with propolis. Preliminary report]. 61
8715223 1995
19
[Chlamydia trachomatis infection in the cervix uteri]. 61
8288136 1993
20
Urogenital infection due to meningococcus in men and women. 61
1907403 1991
21
Secretory IgA against herpes simplex virus in cervical secretions. 61
2852157 1988
22
[Pathogenetic characteristics of cervical erosion in puerperae]. 61
3675219 1987
23
[Acute cervicitis and erosion of the cervix uteri]. 61
3646132 1986
24
A colposcopic and histological study of experimental chlamydial cervicitis in marmosets. 61
6421304 1984
25
The copper-7 device in chronic and IUD-induced acute cervicitis treated with oral estriol. 61
4614936 1974

Variations for Acute Cervicitis

Expression for Acute Cervicitis

Search GEO for disease gene expression data for Acute Cervicitis.

Pathways for Acute Cervicitis

Pathways related to Acute Cervicitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.12 TLR2 IL10 CEACAM1
2
Show member pathways
11.82 TLR2 LY96 CXCL8
3
Show member pathways
11.77 TLR2 LY96 IL10
4
Show member pathways
11.65 TLR2 LY96 CXCL8
5 11.34 TLR2 IL10 CXCL8
6 11.09 IL10 CXCL8
7 11.01 LY96 IL10 CXCL8
8 10.5 TLR2 IL10 CXCL8

GO Terms for Acute Cervicitis

Cellular components related to Acute Cervicitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.1 SERPIND1 LY96 IL10 CXCL8 CEACAM1 ASGR1
2 intrinsic component of plasma membrane GO:0031226 8.96 TLR2 LY96

Biological processes related to Acute Cervicitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.43 TLR2 LY96 IL10
2 toll-like receptor signaling pathway GO:0002224 9.4 TLR2 LY96
3 lipopolysaccharide-mediated signaling pathway GO:0031663 9.37 TLR2 LY96
4 cellular response to lipopolysaccharide GO:0071222 9.33 LY96 IL10 CXCL8
5 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.32 TLR2 LY96
6 negative regulation of interleukin-1 production GO:0032692 8.96 IL10 CEACAM1
7 response to molecule of bacterial origin GO:0002237 8.8 TLR2 IL10 CXCL8

Molecular functions related to Acute Cervicitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 8.96 TLR2 LY96
2 lipopolysaccharide receptor activity GO:0001875 8.62 TLR2 LY96

Sources for Acute Cervicitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....