MCID: ACT017
MIFTS: 50

Acute Chest Syndrome

Categories: Cardiovascular diseases, Respiratory diseases

Aliases & Classifications for Acute Chest Syndrome

MalaCards integrated aliases for Acute Chest Syndrome:

Name: Acute Chest Syndrome 12 55 44 15 73
Acute Chest Syndrome in Sickle Cell Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1584
ICD9CM 35 517.3
MeSH 44 D056586
NCIt 50 C138179
UMLS 73 C0742343

Summaries for Acute Chest Syndrome

Disease Ontology : 12 A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. The crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion. The disease has symptom fever, has symptom pleuritic chest pain, has symptom tachypnea, has symptom cough, has symptom hypoxemia, has symptom marked leukocytosis, and has symptom diffuse infiltrates on chest radiograph.

MalaCards based summary : Acute Chest Syndrome, also known as acute chest syndrome in sickle cell disease, is related to sickle cell disease and asthma, and has symptoms including fever, hypoxemia and cough. An important gene associated with Acute Chest Syndrome is NOS3 (Nitric Oxide Synthase 3), and among its related pathways/superpathways are Innate Immune System and NF-kappaB Signaling. The drugs Hydroxyurea and Amodiaquine have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and endothelial, and related phenotype is cardiovascular system.

Wikipedia : 76 The acute chest syndrome is a vaso-occlusive crisis of the pulmonary vasculature commonly seen in people... more...

Related Diseases for Acute Chest Syndrome

Diseases related to Acute Chest Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 sickle cell disease 31.2 HBB VCAM1
2 asthma 29.7 CD40LG CXCL8 EDN1 PLA2G2A VCAM1
3 ischemia 29.6 EDN1 HMOX1 NOS3
4 sickle cell anemia 10.4
5 toxic myocarditis 10.2 CXCL8 NOS3
6 coronary artery vasospasm 10.1 EDN1 NOS3
7 chronic mountain sickness 10.1 EDN1 NOS3
8 aortic coarctation 10.1 EDN1 NOS3
9 persistent fetal circulation syndrome 10.1 EDN1 NOS3
10 meconium aspiration syndrome 10.1 CXCL8 EDN1
11 sexual disorder 10.1 EDN1 NOS3
12 hepatic vascular disease 10.1 EDN1 NOS3
13 peripheral artery disease 10.1 NOS3 VCAM1
14 angina pectoris 10.1 EDN1 NOS3
15 malignant secondary hypertension 10.1 EDN1 HBB
16 acute mountain sickness 10.1 EDN1 NOS3
17 ischemic optic neuropathy 10.1 EDN1 NOS3
18 bacteriuria 10.0 CD40LG CXCL8
19 nonarteritic anterior ischemic optic neuropathy 10.0 EDN1 NOS3
20 newborn respiratory distress syndrome 10.0 CXCL8 PLA2G2A
21 thalassemia 10.0
22 limb ischemia 10.0 EDN1 NOS3
23 buruli ulcer 10.0 CD40LG HBB
24 sleep apnea 10.0 CXCL8 EDN1 NOS3
25 dengue disease 10.0 CD40LG VCAM1
26 brachydactyly, type e2 10.0 EDN1 NOS3 VCAM1
27 arteries, anomalies of 10.0 EDN1 NOS3 VCAM1
28 mycobacterium abscessus 10.0 CXCL8 HMOX1
29 bronchitis 10.0
30 plastic bronchitis 10.0
31 chronic kidney failure 10.0 EDN1 NOS3 VCAM1
32 microvascular complications of diabetes 1 10.0 CXCL8 EDN1 VCAM1
33 pulmonary fibrosis, idiopathic 9.9 CXCL8 EDN1 VCAM1
34 brucellosis 9.9 CD40LG CXCL8
35 obstructive jaundice 9.9 CXCL8 EDN1
36 siderosis 9.9 HBB HMOX1
37 thrombosis 9.9
38 impotence 9.9 EDN1 NOS3
39 renovascular hypertension 9.8 EDN1 HMOX1 NOS3
40 hepatopulmonary syndrome 9.8 EDN1 HMOX1 NOS3
41 pulmonary hypertension 9.8
42 chlamydia 9.8
43 pneumonia 9.8
44 arteriosclerosis 9.8 EDN1 HMOX1 VCAM1
45 lung disease 9.8 CXCL8 EDN1 HMOX1
46 rheumatoid arthritis 9.7 CD40LG CXCL8 PLA2G2A VCAM1
47 pulmonary edema 9.7 CXCL8 EDN1 HMOX1 NOS3
48 pre-eclampsia 9.7 EDN1 HMOX1 NOS3 VCAM1
49 vascular disease 9.7 EDN1 HMOX1 NOS3 VCAM1
50 beta-thalassemia 9.7

Graphical network of the top 20 diseases related to Acute Chest Syndrome:



Diseases related to Acute Chest Syndrome

Symptoms & Phenotypes for Acute Chest Syndrome

Symptoms:

12
  • fever
  • hypoxemia
  • cough
  • tachypnea
  • pleuritic chest pain
  • marked leukocytosis
  • diffuse infiltrates on chest radiograph

UMLS symptoms related to Acute Chest Syndrome:


dyspnea, apnea, hemoptysis, coughing, hoarseness, cheyne-stokes respiration

MGI Mouse Phenotypes related to Acute Chest Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.1 CD40LG EDN1 HMOX1 NOS3 PLA2G10 VCAM1

Drugs & Therapeutics for Acute Chest Syndrome

Drugs for Acute Chest Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 135)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydroxyurea Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 127-07-1 3657
2
Amodiaquine Approved, Investigational Phase 4 86-42-0 2165
3
Proguanil Approved Phase 4 500-92-5 4923
4
Pyrimethamine Approved, Investigational, Vet_approved Phase 4 58-14-0 4993
5
Sulfadoxine Approved, Investigational Phase 4 2447-57-6 17134
6
Dihydroartemisinin Experimental, Investigational Phase 4 71939-50-9 6918483
7
Piperaquine Experimental, Investigational Phase 4 4085-31-8 5079497
8 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
9 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
10 Artemisinins Phase 4
11 Antiprotozoal Agents Phase 4
12 Folic Acid Antagonists Phase 4
13 Antiparasitic Agents Phase 4
14 Renal Agents Phase 4
15 Anti-Bacterial Agents Phase 4,Phase 2,Phase 1
16 Antimetabolites Phase 4,Phase 2,Phase 1
17 Artemisinine Phase 4
18 Antimalarials Phase 4
19 Anti-Infective Agents, Urinary Phase 4
20
Nitric Oxide Approved Phase 2, Phase 3,Phase 1 10102-43-9 145068
21
Morphine Approved, Investigational Phase 3 57-27-2 5288826
22
Nalbuphine Approved Phase 3 20594-83-6 5311304 5360630
23
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 2, Phase 3 7487-88-9 24083
24
Acetylcysteine Approved, Investigational Phase 3 616-91-1 12035
25
Heparin Approved, Investigational Phase 3,Phase 2 9005-49-6 772 46507594
26
Dalteparin Approved Phase 3,Phase 2 9005-49-6
27
Tinzaparin Approved Phase 3 9005-49-6, 9041-08-1 25244225
28
Ticagrelor Approved Phase 3 274693-27-5 9871419
29
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
30
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
31 Endothelium-Dependent Relaxing Factors Phase 2, Phase 3,Phase 1
32 Vasodilator Agents Phase 2, Phase 3,Phase 1
33 Free Radical Scavengers Phase 2, Phase 3,Phase 3,Phase 1
34 Antioxidants Phase 2, Phase 3,Phase 3,Phase 1
35 Autonomic Agents Phase 2, Phase 3,Phase 3,Phase 1
36 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 3,Phase 1
37 Respiratory System Agents Phase 2, Phase 3,Phase 3,Phase 1
38 Neurotransmitter Agents Phase 2, Phase 3,Phase 3,Phase 1
39 Anti-Asthmatic Agents Phase 2, Phase 3,Phase 1
40 Bronchodilator Agents Phase 2, Phase 3,Phase 1
41 Protective Agents Phase 2, Phase 3,Phase 3,Phase 1
42 Analgesics Phase 3,Phase 2
43 Narcotic Antagonists Phase 3
44 Analgesics, Opioid Phase 3
45 Narcotics Phase 3
46 Central Nervous System Depressants Phase 3,Phase 2
47 Tocolytic Agents Phase 2, Phase 3,Phase 1
48 Anesthetics Phase 2, Phase 3
49 Anti-Arrhythmia Agents Phase 2, Phase 3
50 Anticonvulsants Phase 2, Phase 3

Interventional clinical trials:

(show top 50) (show all 81)
# Name Status NCT ID Phase Drugs
1 Enhancing Preventive Therapy of Malaria In Children With Sickle Cell Anemia in East Africa (EPiTOMISE) Recruiting NCT03178643 Phase 4 Proguanil Oral Tablet;Sulfadoxine/Pyrimethanine-Amodiaquine (SP-AQ);Dihydroartemisinin-Piperaquine (DP)
2 Risk Clinical Stratification of Sickle Cell Disease in Nigeria, Assessment of Efficacy/Safety of Hydroxyurea Treatment Active, not recruiting NCT02149537 Phase 4 hydroxyurea
3 Effect of Inhaled Nitric Oxide in Acute Chest Syndrome (INOSTA Study) Completed NCT00748423 Phase 2, Phase 3 Nitric Oxide;Placebo
4 Choosing Opioid Management for Pain and Analyzing Acute Chest Syndrome (ACS) Rates Equally Completed NCT01380197 Phase 3 Morphine;Nubain
5 Evaluation of Repeat Administration of Purified Poloxamer 188 Completed NCT02449616 Phase 3 MST-188
6 Evaluation of Purified Poloxamer 188 in Vaso-Occlusive Crisis of Sickle Cell Disease (EPIC) Completed NCT01737814 Phase 3 Saline;MST-188
7 Intravenous Magnesium for Sickle Cell Vasoocclusive Crisis Completed NCT01197417 Phase 2, Phase 3 Intravenous Magnesium Sulfate;Normal Saline Placebo
8 N-Acetylcysteine in Patients With Sickle Cell Disease Completed NCT01849016 Phase 3 N-Acetylcysteine;Placebo
9 Therapeutic Anticoagulation Strategy for Acute Chest Syndrome Recruiting NCT02580773 Phase 3 Prophylactic anticoagulation ( INNOHEP®);Curative anticoagulation ( INNOHEP®)
10 Oxygen Therapy and Pregnancy in Sickle Cell Disease Recruiting NCT02813850 Phase 3
11 Safety Of Rivipansel (GMI-1070) In The Treatment Of One or More Vaso-occlusive Crises In Hospitalized Subjects With Sickle Cell Disease Recruiting NCT02433158 Phase 3 Rivipansel
12 Effect of Ticagrelor vs. Placebo in the Reduction of Vaso-occlusive Crises in Pediatric Patients With Sickle Cell Disease Recruiting NCT03615924 Phase 3 Ticagrelor;Placebo
13 Optimizing Hydroxyurea Therapy in Children With SCA In Malaria Endemic Areas Recruiting NCT03128515 Phase 3 Hydroxyurea
14 Primary Prevention of Stroke in Children With SCD in Sub-Saharan Africa II Active, not recruiting NCT02560935 Phase 3 Hydroxyurea (Moderate Dose);Hydroxyurea (Low Dose)
15 Dexamethasone to Treat Acute Chest Syndrome in People With Sickle Cell Disease Terminated NCT00530270 Phase 3 Dexamethasone;Placebo
16 A Study of Prasugrel in Pediatric Participants With Sickle Cell Disease (SCD) Terminated NCT01794000 Phase 3 Prasugrel;Placebo
17 IMPACTS Trial: Investigation of the Modulation of Phospholipase in Acute Chest Syndrome Completed NCT00434473 Phase 2 A-001
18 Nitric Oxide Therapy for Acute Chest Syndrome in Sickle Cell Disease Children Completed NCT01089439 Phase 2 Nitric oxide by inhalation INOMAX;Placebo
19 Arginine Treatment of Acute Chest Syndrome (Pneumonia) in Sickle Cell Disease Patients Completed NCT00029731 Phase 2 Arginine hydrochloride
20 A Phase II Trial of Regadenoson in Sickle Cell Anemia Completed NCT01788631 Phase 2 Regadenoson;Placebo
21 Treatment of Sickle Cell Patients Hospitalized in Pain Crisis With Prophylactic Dose Low-molecular-weight Heparin (LMWH) Versus Placebo Completed NCT01419977 Phase 2 Placebo;Dalteparin
22 Treatment of Hemoglobin SC Disease Completed NCT02336373 Phase 2 hydroxyurea
23 Effects of Nitric Oxide and Nitroglycerin in Patients With Sickle Cell Anemia Completed NCT00001716 Phase 2 Nitric Oxide;Nitroglycerin
24 Nitric Oxide Inhalation to Treat Sickle Cell Pain Crises Completed NCT00094887 Phase 2 Nitric Oxide;Placebo
25 A Study of SANGUINATE for the Treatment of Vaso-occlusive Crisis (VOC) in Adult Sickle Cell Disease Patients Completed NCT02672540 Phase 2 SANGUINATE 320 mg/kg;Normal Saline
26 Prasugrel Versus Placebo in Adult Sickle Cell Disease Completed NCT01167023 Phase 2 Prasugrel;Placebo
27 Defibrotide in Sickle Cell Disease-Related Acute Chest Syndrome Recruiting NCT03805581 Phase 2 Defibrotide
28 HLA-Identical Sibling Donor Bone Marrow Transplantation for Individuals With Severe Sickle Cell Disease Using a Reduced Intensity Conditioning Regimen Recruiting NCT02776202 Phase 2 Fludarabine monophosphate
29 Rifaximin to Modify the Disease Course in Sickle Cell Disease Recruiting NCT03719729 Phase 2 Rifaximin
30 Ph I/II Study of Allogeneic SCT for Clinically Aggressive Sickle Cell Disease (SCD) Recruiting NCT01499888 Phase 1, Phase 2 Alemtuzumab;Sirolimus
31 Arginine Therapy for Sickle Cell Disease Pain Recruiting NCT02536170 Phase 2 L-arginine;L-arginine Loading Dose
32 Pharmacokinetics and Pharmacodynamics Study of SEG101 (Crizanlizumab) in Sickle Cell Disease (SCD) Patients With Vaso- Occlusive Crisis (VOC) Recruiting NCT03264989 Phase 2 crizanlizumab
33 Study of Dose Confirmation and Safety of Crizanlizumab in Pediatric Sickle Cell Disease Patients Recruiting NCT03474965 Phase 2 Crizanlizumab
34 T-Cell Depleted Alternative Donor Bone Marrow Transplant for Sickle Cell Disease and Thalassemia Recruiting NCT03653338 Phase 1, Phase 2 Hydroxyurea;Rituximab;Alemtuzumab;Fludarabine;Thiotepa
35 Vitamin D for Sickle-cell Respiratory Complications Active, not recruiting NCT01443728 Phase 2 Vitamin D3;Vitamin D3
36 SCD-Haplo: Phase II Study of HLA-Haploidentical SCT for Aggressive SCD Active, not recruiting NCT02013375 Phase 2 Alemtuzumab;Cyclophosphamide;Sirolimus
37 A Study Evaluating the Efficacy and Safety of LentiGlobin BB305 Drug Product in Beta-Thalassemia Major and Sickle Cell Disease Active, not recruiting NCT02151526 Phase 1, Phase 2
38 Feasibility Study of Unfractionated Heparin in Acute Chest Syndrome Terminated NCT02098993 Phase 2 Unfractionated heparin
39 A Study of Varespladib Infusion in Subjects With Sickle Cell Disease. Terminated NCT01522196 Phase 2 Varespladib
40 Treatment of Adult Patients With Hemoglobin SC Disease (SCYTHE) Terminated NCT02640573 Phase 2 Hydroxyurea
41 Hydroxyurea and Magnesium Pidolate to Treat People With Hemoglobin Sickle Cell Disease Terminated NCT00532883 Phase 2 Hydroxyurea;Magnesium Pidolate
42 Evaluation of Different Dose Regimens of Aes-103 Given for 28 Days to Subjects With Stable Sickle Cell Disease Terminated NCT01987908 Phase 2 Aes-103
43 Macrolide Therapy to Improve Forced Expiratory Volume in 1 Second in Adults With Sickle Cell Disease Withdrawn NCT02960503 Phase 1, Phase 2 Azithromycin
44 Phase 2 Study of MP4CO to Treat Vaso-occlusive Sickle Crisis Withdrawn NCT01925001 Phase 2 MP4CO;Sodium chloride solution
45 A Phase 1 Study of Continuous Intravenous L-citrulline During Sickle Cell Pain Crisis or Acute Chest Syndrome Unknown status NCT02697240 Phase 1 Intravenous citrulline
46 Inhaled Corticosteroid Use to Prevent Acute Chest Syndrome Recurrence in Children Between 1 and 4 With Sickle Cell Disease: a Feasibility Trial Completed NCT02187445 Phase 1 Budesonide inhalation suspension
47 Pilot and Feasibility Trial of Plerixafor for Hematopoietic Stem Cell (HSC) Mobilization in Patients With Sickle Cell Disease Pilot and Feasibility Trial of Plerixafor for Hematopoietic Stem Cell (HSC) Mobilization in Patients With Sickle Cell Disease Completed NCT02989701 Phase 1 Plerixafor
48 Quantifying the Presence of Lung Disease and Pulmonary Hypertension in Children With Sickle Cell Disease Completed NCT01895998 Phase 1 Albuterol
49 Nitric Oxide and Transfusion Therapy for Sickle Cell Patients With Pulmonary Hypertension Completed NCT00023296 Phase 1 Nitric Oxide
50 Escalation of Plerixafor for Mobilization of CD34+ Hematopoietic Progenitor Cells and Evaluation of Globin Gene Transfer in Patients With Sickle Cell Disease Recruiting NCT02193191 Phase 1 Plerixafor

Search NIH Clinical Center for Acute Chest Syndrome

Cochrane evidence based reviews: acute chest syndrome

Genetic Tests for Acute Chest Syndrome

Anatomical Context for Acute Chest Syndrome

MalaCards organs/tissues related to Acute Chest Syndrome:

41
Lung, Bone, Endothelial, Kidney, Bone Marrow, Heart, Thyroid

Publications for Acute Chest Syndrome

Articles related to Acute Chest Syndrome:

(show top 50) (show all 272)
# Title Authors Year
1
Acute Chest Syndrome Progressing to ARDS in a Patient of 25-Week Gestation. ( 29666710 )
2018
2
Early Noninvasive Ventilation and Nonroutine Transfusion for Acute Chest Syndrome in Sickle Cell Disease in Children: A Descriptive Study. ( 29356722 )
2018
3
Successful Use of Veno-Venous Extracorporeal Membrane Oxygenation in an Adult Patient with Sickle Cell Anemia and Severe Acute Chest Syndrome. ( 29633667 )
2018
4
Augmented NRF2 activation protects adult sickle mice from lethal acute chest syndrome. ( 29923176 )
2018
5
Early initiation of inhaled corticosteroids does not decrease acute chest syndrome morbidity in pediatric patients with sickle cell disease. ( 29550053 )
2018
6
Acute chest syndrome among children hospitalized with vaso-occlusive crisis: A nationwide study in the United States. ( 29134776 )
2018
7
Comprehensive management reduces incidence and mortality of acute chest syndrome in patients with sickle cell disease. ( 29205462 )
2018
8
Factors Associated With Mechanical Ventilation Use in Children With Sickle Cell Disease and Acute Chest Syndrome. ( 29923940 )
2018
9
The McConnell Sign is Seen in Patients With Acute Chest Syndrome. ( 29498079 )
2018
10
Recurrent Acute Chest Syndrome in Pediatric Sickle Cell Disease: Clinical Features and Risk Factors. ( 29200151 )
2018
11
Acute chest syndrome in sickle cell disease. ( 29648482 )
2018
12
Aeroallergen sensitization predicts acute chest syndrome in children with sickle cell anaemia. ( 29363738 )
2018
13
Bedside ultrasound as a predictive tool for acute chest syndrome in sickle cell patients. ( 30017686 )
2018
14
Limited Exchange Transfusion Can Be Very Beneficial in Sickle Cell Anemia with Acute Chest Syndrome: A Case Report from Tanzania. ( 30034890 )
2018
15
Children with HbSβ0 thalassemia have higher hemoglobin levels and lower incidence rate of acute chest syndrome compared to children with HbSS. ( 30094930 )
2018
16
Bronchodilator Use for Acute Chest Syndrome Among Large Pediatric Hospitals in North America. ( 30173539 )
2018
17
Acute chest syndrome in sickle cell anaemia: higher serum levels of interleukin-8 and highly sensitive C-reactive proteins are associated with impaired lung function. ( 30295174 )
2018
18
Association of plasma CD40L with acute chest syndrome in sickle cell anemia. ( 28609750 )
2017
19
Extracorporeal Lung Support in Acute Chest Syndrome Associated With Sickle Cell Disease: A Rare Report of a Common Case. ( 28703372 )
2017
20
Association of Guideline-Adherent Antibiotic Treatment With Readmission of Children With Sickle Cell Disease Hospitalized With Acute Chest Syndrome. ( 28892533 )
2017
21
Exosomes contribute to endothelial integrity and acute chest syndrome risk: Preliminary findings. ( 28486752 )
2017
22
Plastic bronchitis: An unusual complication of acute chest syndrome in adult. ( 28443234 )
2017
23
Acute Splenic Sequestration Crisis After Red Blood Cell Exchange for Acute Chest Syndrome in an Adult With Sickle I^-Thalassemia: What Went Wrong? ( 29205801 )
2017
24
Inflammatory and endothelial markers during vaso-occlusive crisis and acute chest syndrome in sickle cell disease. ( 28741692 )
2017
25
A clinical risk score for pulmonary artery thrombosis during acute chest syndrome in adult patients with sickle cell disease. ( 28905364 )
2017
26
Acute Chest Syndrome in Children with Sickle Cell Disease. ( 29279787 )
2017
27
Accuracy of Point-of-Care Lung Ultrasonography for Diagnosis of Acute Chest Syndrome in Pediatric Patients with Sickle Cell Disease and Fever. ( 27155438 )
2016
28
Rapidly progressive acute chest syndrome in individuals with sickle cell anemia. ( 27543812 )
2016
29
Inhaled bronchodilators for acute chest syndrome in people with sickle cell disease. ( 27673392 )
2016
30
Rare Case of Posterior Reversible Leukoencephalopathy Syndrome Secondary to Acute Chest Syndrome. ( 27957377 )
2016
31
Score Predicting Acute Chest Syndrome During Vaso-occlusive Crises in Adult Sickle-cell Disease Patients. ( 27412264 )
2016
32
Original Research: Acute chest syndrome in sickle cell disease: Effect of genotype and asthma. ( 26936083 )
2016
33
Sickle cell crisis - Acute chest syndrome. ( 27728299 )
2016
34
Bedside Lung Ultrasound During Acute Chest Syndrome in Sickle Cell Disease. ( 26886600 )
2016
35
Effect of automated red cell exchanges on oxygen saturation on-air, blood parameters and length of hospitalization in sickle cell disease patients with acute chest syndrome. ( 27397962 )
2016
36
Are We Missing the Mark? Fever, Respiratory Symptoms, Chest Radiographs and Acute Chest Syndrome in Sickle Cell Disease. ( 27153121 )
2016
37
Prevalence of acute kidney injury during pediatric admissions for acute chest syndrome. ( 27011218 )
2016
38
The intersection between asthma and acute chest syndrome in children with sickle-cell anaemia. ( 27353685 )
2016
39
Acute Chest Syndrome, Asthma, and Lung Function in Sickle Cell Disease. Which Is the Chicken, and Which Is the Egg? ( 27509149 )
2016
40
Blood transfusions for treating acute chest syndrome in people with sickle cell disease. ( 27574910 )
2016
41
Extracorporeal membrane oxygenation for the treatment of adult sickle cell acute chest syndrome. ( 26130498 )
2015
42
Platelets Decline during Vaso-Occlusive Crisis as a Predictor of Acute Chest Syndrome in Sickle Cell Disease. ( 26453077 )
2015
43
Increased risk of severe vaso-occlusive episodes after initial acute chest syndrome in children with sickle cell anemia less than 4 years old: Sleep and asthma cohort. ( 25619382 )
2015
44
Hashimoto's thyroiditis and acute chest syndrome revealing sickle cell anemia in a 32 years female patient. ( 26327979 )
2015
45
A case of acute chest syndrome complicated by diffuse cerebral infarcts in an adult with HbSI^-thalassemia(.). ( 26088144 )
2015
46
The Acute Chest Syndrome in Cameroonian children living with sickle cell disease. ( 26391669 )
2015
47
Age-dependent pathophysiology of acute chest syndrome in children with sickle cell disease. ( 25683565 )
2015
48
Positron Emission Tomography With 18F-Fluorodeoxyglucose in Patients With Sickle Cell Acute Chest Syndrome. ( 25950690 )
2015
49
Inhaled nitric oxide for acute chest syndrome in adult sickle cell patients: a randomized controlled study. ( 26431718 )
2015
50
Red blood cell storage duration is not associated with clinical outcomes for acute chest syndrome in children with sickle cell disease. ( 26033266 )
2015

Variations for Acute Chest Syndrome

Expression for Acute Chest Syndrome

Search GEO for disease gene expression data for Acute Chest Syndrome.

Pathways for Acute Chest Syndrome

Pathways related to Acute Chest Syndrome according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.66 CD40LG CXCL8 HBB HMOX1 NOS3 PLA2G2A
2 12.3 CD40LG HMOX1 VCAM1
3
Show member pathways
12.18 CXCL8 HMOX1 NOS3
4
Show member pathways
11.92 CXCL8 EDN1 HMOX1
5 11.69 CXCL8 HMOX1 VCAM1
6 11.61 EDN1 HMOX1 NOS3
7 11.6 EDN1 HMOX1 NOS3 VCAM1
8 11.56 CD40LG CXCL8 VCAM1
9 11.34 CXCL8 EDN1 HMOX1
10 11.33 EDN1 NOS3
11
Show member pathways
11.3 CD40LG CXCL8 VCAM1
12
Show member pathways
11.29 PLA2G10 PLA2G2A
13 11.25 CXCL8 EDN1 NOS3 VCAM1
14 11.24 NOS3 VCAM1
15
Show member pathways
11.22 PLA2G10 PLA2G2A
16 11.21 CXCL8 VCAM1
17 11.09 HBB VCAM1
18 11.07 EDN1 NOS3
19 10.96 NOS3 PLA2G2A
20 10.96 CXCL8 HMOX1 NOS3
21 10.76 CXCL8 HMOX1
22 10.61 CD40LG CXCL8 HBB VCAM1

GO Terms for Acute Chest Syndrome

Cellular components related to Acute Chest Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 CD40LG CXCL8 EDN1 HBB PLA2G10 PLA2G2A
2 extracellular space GO:0005615 9.23 CD40LG CXCL8 EDN1 HBB HMOX1 PLA2G10

Biological processes related to Acute Chest Syndrome according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.8 CXCL8 HMOX1 VCAM1
2 angiogenesis GO:0001525 9.78 CXCL8 HMOX1 NOS3
3 response to hypoxia GO:0001666 9.72 EDN1 HMOX1 VCAM1
4 response to lipopolysaccharide GO:0032496 9.7 EDN1 NOS3 VCAM1
5 positive regulation of angiogenesis GO:0045766 9.67 CXCL8 HMOX1 NOS3
6 positive regulation of smooth muscle cell proliferation GO:0048661 9.63 EDN1 HMOX1
7 response to hydrogen peroxide GO:0042542 9.63 HBB HMOX1
8 positive regulation of nitric oxide biosynthetic process GO:0045429 9.62 EDN1 HBB
9 phosphatidic acid biosynthetic process GO:0006654 9.61 PLA2G10 PLA2G2A
10 cellular response to tumor necrosis factor GO:0071356 9.61 CXCL8 EDN1 VCAM1
11 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.6 HMOX1 NOS3
12 leukocyte cell-cell adhesion GO:0007159 9.59 CD40LG VCAM1
13 phosphatidylcholine acyl-chain remodeling GO:0036151 9.58 PLA2G10 PLA2G2A
14 phosphatidylethanolamine acyl-chain remodeling GO:0036152 9.58 PLA2G10 PLA2G2A
15 arachidonic acid secretion GO:0050482 9.57 PLA2G10 PLA2G2A
16 positive regulation of neutrophil chemotaxis GO:0090023 9.56 CXCL8 EDN1
17 phosphatidylserine acyl-chain remodeling GO:0036150 9.54 PLA2G10 PLA2G2A
18 phosphatidylglycerol acyl-chain remodeling GO:0036148 9.51 PLA2G10 PLA2G2A
19 phosphatidylinositol acyl-chain remodeling GO:0036149 9.48 PLA2G10 PLA2G2A
20 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.46 PLA2G10 PLA2G2A
21 response to nicotine GO:0035094 9.43 EDN1 HMOX1 VCAM1
22 positive regulation of prostaglandin secretion GO:0032308 9.4 EDN1 PLA2G10
23 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.37 EDN1 NOS3
24 nitric oxide transport GO:0030185 9.32 EDN1 HBB
25 smooth muscle hyperplasia GO:0014806 9.16 HMOX1 NOS3
26 regulation of blood vessel size GO:0050880 9.13 EDN1 HBB NOS3
27 regulation of blood pressure GO:0008217 8.92 EDN1 HBB HMOX1 NOS3

Molecular functions related to Acute Chest Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.5 CD40LG CXCL8 EDN1
2 phospholipase A2 activity GO:0004623 9.37 PLA2G10 PLA2G2A
3 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) GO:0102567 9.26 PLA2G10 PLA2G2A
4 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) GO:0102568 9.16 PLA2G10 PLA2G2A
5 calcium-dependent phospholipase A2 activity GO:0047498 8.96 PLA2G10 PLA2G2A
6 heme binding GO:0020037 8.8 HBB HMOX1 NOS3

Sources for Acute Chest Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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