MCID: ACT017
MIFTS: 49

Acute Chest Syndrome

Categories: Cardiovascular diseases, Respiratory diseases

Aliases & Classifications for Acute Chest Syndrome

MalaCards integrated aliases for Acute Chest Syndrome:

Name: Acute Chest Syndrome 12 56 45 15 17 74
Acute Chest Syndrome in Sickle Cell Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1584
ICD9CM 36 517.3
MeSH 45 D056586
NCIt 51 C138179
UMLS 74 C0742343

Summaries for Acute Chest Syndrome

Disease Ontology : 12 A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. The crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion. The disease has symptom fever, has symptom pleuritic chest pain, has symptom tachypnea, has symptom cough, has symptom hypoxemia, has symptom marked leukocytosis, and has symptom diffuse infiltrates on chest radiograph.

MalaCards based summary : Acute Chest Syndrome, also known as acute chest syndrome in sickle cell disease, is related to sickle cell disease and sickle cell anemia, and has symptoms including fever, hypoxemia and cough. An important gene associated with Acute Chest Syndrome is NOS3 (Nitric Oxide Synthase 3), and among its related pathways/superpathways are Fluid shear stress and atherosclerosis and NF-kappa B signaling pathway. The drugs Hydroxyurea and Proguanil have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and bone marrow, and related phenotype is cardiovascular system.

Wikipedia : 77 The acute chest syndrome is a vaso-occlusive crisis of the pulmonary vasculature commonly seen in people... more...

Related Diseases for Acute Chest Syndrome

Diseases related to Acute Chest Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 sickle cell disease 31.0 G6PD HBB VCAM1
2 sickle cell anemia 30.3 G6PD HBB VCAM1
3 asthma 29.8 CD40LG CXCL8 EDN1 VCAM1
4 sickle cell - hemoglobin d disease 11.3
5 hemoglobin se disease 11.0
6 toxic myocarditis 10.3 CXCL8 NOS3
7 coronary artery vasospasm 10.2 EDN1 NOS3
8 chronic mountain sickness 10.2 EDN1 NOS3
9 aortic coarctation 10.2 EDN1 NOS3
10 peripheral artery disease 10.2 NOS3 VCAM1
11 viral encephalitis 10.2 CXCL8 VCAM1
12 persistent fetal circulation syndrome 10.2 EDN1 NOS3
13 sexual disorder 10.2 EDN1 NOS3
14 hepatic vascular disease 10.2 EDN1 NOS3
15 meconium aspiration syndrome 10.2 CXCL8 EDN1
16 renovascular hypertension 10.2 EDN1 NOS3
17 angina pectoris 10.1 EDN1 NOS3
18 acute mountain sickness 10.1 EDN1 NOS3
19 hepatopulmonary syndrome 10.1 EDN1 NOS3
20 malignant secondary hypertension 10.1 EDN1 HBB
21 nonarteritic anterior ischemic optic neuropathy 10.1 EDN1 NOS3
22 buruli ulcer 10.1 CD40LG HBB
23 limb ischemia 10.1 EDN1 NOS3
24 dengue disease 10.1 CD40LG VCAM1
25 thalassemia 10.1
26 glucosephosphate dehydrogenase deficiency 10.0 G6PD HBB
27 impotence 10.0 EDN1 NOS3
28 brucellosis 10.0 CD40LG CXCL8
29 endocarditis 10.0 CXCL8 VCAM1
30 obstructive jaundice 10.0 CXCL8 EDN1
31 orthostatic intolerance 10.0 EDN1 NOS3
32 methemoglobinemia 10.0 G6PD HBB
33 pulmonary edema 10.0 CXCL8 EDN1 NOS3
34 sleep apnea 10.0 CXCL8 EDN1 NOS3
35 bronchitis 10.0
36 plastic bronchitis 10.0
37 brachydactyly, type e2 10.0 EDN1 NOS3 VCAM1
38 arteries, anomalies of 10.0 EDN1 NOS3 VCAM1
39 hemoglobin h disease 10.0 G6PD HBB
40 chronic kidney failure 10.0 EDN1 NOS3 VCAM1
41 microvascular complications of diabetes 1 9.9 CXCL8 EDN1 VCAM1
42 pre-eclampsia 9.9 EDN1 NOS3 VCAM1
43 pulmonary fibrosis, idiopathic 9.9 CXCL8 EDN1 VCAM1
44 vascular disease 9.9 EDN1 NOS3 VCAM1
45 thrombosis 9.9
46 ischemia 9.9
47 acute respiratory distress syndrome 9.9
48 idiopathic interstitial pneumonia 9.9 CXCL8 EDN1
49 ischemic optic neuropathy 9.9 EDN1 G6PD NOS3
50 beta-thalassemia 9.8

Graphical network of the top 20 diseases related to Acute Chest Syndrome:



Diseases related to Acute Chest Syndrome

Symptoms & Phenotypes for Acute Chest Syndrome

Symptoms:

12
  • fever
  • hypoxemia
  • cough
  • tachypnea
  • pleuritic chest pain
  • marked leukocytosis
  • diffuse infiltrates on chest radiograph

UMLS symptoms related to Acute Chest Syndrome:


dyspnea, apnea, hemoptysis, cheyne-stokes respiration, coughing, hoarseness

MGI Mouse Phenotypes related to Acute Chest Syndrome:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.1 CD40LG EDN1 G6PD NOS3 PLA2G10 VCAM1

Drugs & Therapeutics for Acute Chest Syndrome

Drugs for Acute Chest Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 149)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydroxyurea Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1 127-07-1 3657
2
Proguanil Approved Phase 4 500-92-5 4923
3
Amodiaquine Approved, Investigational Phase 4 86-42-0 2165
4
Sulfadoxine Approved, Investigational Phase 4 2447-57-6 17134
5
Pyrimethamine Approved, Investigational, Vet_approved Phase 4 58-14-0 4993
6
Piperaquine Experimental, Investigational Phase 4 4085-31-8 5079497
7
Dihydroartemisinin Experimental, Investigational Phase 4 71939-50-9 6918483
8 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2
9 Anti-Bacterial Agents Phase 4,Phase 1,Phase 2
10 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable
11 Antiparasitic Agents Phase 4
12 Folic Acid Antagonists Phase 4
13 Renal Agents Phase 4
14 Anti-Infective Agents, Urinary Phase 4
15 Antiprotozoal Agents Phase 4
16 Antimalarials Phase 4
17 Artemisinins Phase 4
18 Artemisinine Phase 4
19 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1
20
Nitric Oxide Approved Phase 2, Phase 3,Phase 1 10102-43-9 145068
21
Nalbuphine Approved Phase 3 20594-83-6 5360630 5311304
22
Morphine Approved, Investigational Phase 3 57-27-2 5288826
23
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 2, Phase 3 7487-88-9 24083
24
Acetylcysteine Approved, Investigational Phase 3 616-91-1 12035
25
Heparin Approved, Investigational Phase 3,Phase 2 9005-49-6 772 46507594
26
Dalteparin Approved Phase 3,Phase 2 9005-49-6
27
Tinzaparin Approved Phase 3 9041-08-1, 9005-49-6 25244225
28
Ticagrelor Approved Phase 3 274693-27-5 9871419
29
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
30
Atorvastatin Approved Phase 3 134523-00-5 60823
31
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
32
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
33
Calcium Approved, Nutraceutical Phase 2, Phase 3 7440-70-2 271
34 Antirheumatic Agents Phase 3,Phase 2,Phase 1
35 Vasodilator Agents Phase 2, Phase 3,Phase 1
36 Bronchodilator Agents Phase 2, Phase 3,Phase 1
37 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 3,Phase 1
38 Protective Agents Phase 2, Phase 3,Phase 3,Phase 1
39 Autonomic Agents Phase 2, Phase 3,Phase 3,Phase 1
40 Neurotransmitter Agents Phase 2, Phase 3,Phase 3,Phase 1
41 Endothelium-Dependent Relaxing Factors Phase 2, Phase 3,Phase 1
42 Antioxidants Phase 2, Phase 3,Phase 3,Phase 1
43 Free Radical Scavengers Phase 2, Phase 3,Phase 3,Phase 1
44 Respiratory System Agents Phase 2, Phase 3,Phase 3,Phase 1
45 Anti-Asthmatic Agents Phase 2, Phase 3,Phase 1
46 Central Nervous System Depressants Phase 3,Phase 2
47 Narcotics Phase 3
48 Analgesics, Opioid Phase 3
49 Analgesics Phase 3,Phase 2
50 Hormones Phase 2, Phase 3,Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 83)
# Name Status NCT ID Phase Drugs
1 Enhancing Preventive Therapy of Malaria In Children With Sickle Cell Anemia in East Africa (EPiTOMISE) Recruiting NCT03178643 Phase 4 Proguanil Oral Tablet;Sulfadoxine/Pyrimethanine-Amodiaquine (SP-AQ);Dihydroartemisinin-Piperaquine (DP)
2 Risk Clinical Stratification of Sickle Cell Disease in Nigeria, Assessment of Efficacy/Safety of Hydroxyurea Treatment Active, not recruiting NCT02149537 Phase 4 hydroxyurea
3 Effect of Inhaled Nitric Oxide in Acute Chest Syndrome (INOSTA Study) Completed NCT00748423 Phase 2, Phase 3 Nitric Oxide;Placebo
4 Choosing Opioid Management for Pain and Analyzing Acute Chest Syndrome (ACS) Rates Equally Completed NCT01380197 Phase 3 Morphine;Nubain
5 Evaluation of Repeat Administration of Purified Poloxamer 188 Completed NCT02449616 Phase 3 MST-188
6 Evaluation of Purified Poloxamer 188 in Vaso-Occlusive Crisis of Sickle Cell Disease (EPIC) Completed NCT01737814 Phase 3 Saline;MST-188
7 Intravenous Magnesium for Sickle Cell Vasoocclusive Crisis Completed NCT01197417 Phase 2, Phase 3 Intravenous Magnesium Sulfate;Normal Saline Placebo
8 N-Acetylcysteine in Patients With Sickle Cell Disease Completed NCT01849016 Phase 3 N-Acetylcysteine;Placebo
9 Therapeutic Anticoagulation Strategy for Acute Chest Syndrome Recruiting NCT02580773 Phase 3 Prophylactic anticoagulation ( INNOHEP®);Curative anticoagulation ( INNOHEP®)
10 Oxygen Therapy and Pregnancy in Sickle Cell Disease Recruiting NCT02813850 Phase 3
11 Safety Of Rivipansel (GMI-1070) In The Treatment Of One or More Vaso-occlusive Crises In Hospitalized Subjects With Sickle Cell Disease Recruiting NCT02433158 Phase 3 Rivipansel
12 Effect of Ticagrelor vs. Placebo in the Reduction of Vaso-occlusive Crises in Pediatric Patients With Sickle Cell Disease Recruiting NCT03615924 Phase 3 Ticagrelor;Placebo
13 Optimizing Hydroxyurea Therapy in Children With SCA In Malaria Endemic Areas Recruiting NCT03128515 Phase 3 Hydroxyurea
14 Primary Prevention of Stroke in Children With SCD in Sub-Saharan Africa II Active, not recruiting NCT02560935 Phase 3 Hydroxyurea (Moderate Dose);Hydroxyurea (Low Dose)
15 Effect of Platelet Inhibition and / or Lipid Lowering in Non-ACS-patients With Positive Troponin Not yet recruiting NCT03820466 Phase 3 Aspirin;Atorvastatin;Placebo Aspirin;Placebo Atorvastatin
16 A Sickle CEll Disease ComplicatioN Trial Not yet recruiting NCT02604368 Phase 3 SC411;Placebo
17 Dexamethasone to Treat Acute Chest Syndrome in People With Sickle Cell Disease Terminated NCT00530270 Phase 3 Dexamethasone;Placebo
18 A Study of Prasugrel in Pediatric Participants With Sickle Cell Disease (SCD) Terminated NCT01794000 Phase 3 Prasugrel;Placebo
19 Ph I/II Study of Allogeneic SCT for Clinically Aggressive Sickle Cell Disease (SCD) Unknown status NCT01499888 Phase 1, Phase 2 Alemtuzumab;Sirolimus
20 SCD-Haplo: Phase II Study of HLA-Haploidentical SCT for Aggressive SCD Unknown status NCT02013375 Phase 2 Alemtuzumab;Cyclophosphamide;Sirolimus
21 IMPACTS Trial: Investigation of the Modulation of Phospholipase in Acute Chest Syndrome Completed NCT00434473 Phase 2 A-001
22 Nitric Oxide Therapy for Acute Chest Syndrome in Sickle Cell Disease Children Completed NCT01089439 Phase 2 Nitric oxide by inhalation INOMAX;Placebo
23 Arginine Treatment of Acute Chest Syndrome (Pneumonia) in Sickle Cell Disease Patients Completed NCT00029731 Phase 2 Arginine hydrochloride
24 A Phase II Trial of Regadenoson in Sickle Cell Anemia Completed NCT01788631 Phase 2 Regadenoson;Placebo
25 Assessment of Algorithm-Based Hydroxyurea Dosing on Fetal Hemoglobin Response, Acute Complications, and Organ Function in People With Sickle Cell Disease Completed NCT02225132 Phase 1, Phase 2 Hydroxyurea
26 Treatment of Sickle Cell Patients Hospitalized in Pain Crisis With Prophylactic Dose Low-molecular-weight Heparin (LMWH) Versus Placebo Completed NCT01419977 Phase 2 Placebo;Dalteparin
27 Treatment of Hemoglobin SC Disease Completed NCT02336373 Phase 2 hydroxyurea
28 Effects of Nitric Oxide and Nitroglycerin in Patients With Sickle Cell Anemia Completed NCT00001716 Phase 2 Nitric Oxide;Nitroglycerin
29 Nitric Oxide Inhalation to Treat Sickle Cell Pain Crises Completed NCT00094887 Phase 2 Nitric Oxide;Placebo
30 A Study of SANGUINATE for the Treatment of Vaso-occlusive Crisis (VOC) in Adult Sickle Cell Disease Patients Completed NCT02672540 Phase 2 SANGUINATE 320 mg/kg;Normal Saline
31 Prasugrel Versus Placebo in Adult Sickle Cell Disease Completed NCT01167023 Phase 2 Prasugrel;Placebo
32 Defibrotide in Sickle Cell Disease-Related Acute Chest Syndrome Recruiting NCT03805581 Phase 2 Defibrotide
33 HLA-Identical Sibling Donor Bone Marrow Transplantation for Individuals With Severe Sickle Cell Disease Using a Reduced Intensity Conditioning Regimen Recruiting NCT02776202 Phase 2 Fludarabine monophosphate
34 Rifaximin to Modify the Disease Course in Sickle Cell Disease Recruiting NCT03719729 Phase 2 Rifaximin
35 Arginine Therapy for Sickle Cell Disease Pain Recruiting NCT02536170 Phase 2 L-arginine;L-arginine Loading Dose
36 Pharmacokinetics and Pharmacodynamics Study of SEG101 (Crizanlizumab) in Sickle Cell Disease (SCD) Patients With Vaso- Occlusive Crisis (VOC) Recruiting NCT03264989 Phase 2 crizanlizumab
37 Study of Dose Confirmation and Safety of Crizanlizumab in Pediatric Sickle Cell Disease Patients Recruiting NCT03474965 Phase 2 Crizanlizumab
38 T-Cell Depleted Alternative Donor Bone Marrow Transplant for Sickle Cell Disease (SCD) and Other Anemias Recruiting NCT03653338 Phase 1, Phase 2 Hydroxyurea;Rituximab;Alemtuzumab;Fludarabine;Thiotepa
39 Vitamin D for Sickle-cell Respiratory Complications Active, not recruiting NCT01443728 Phase 2 Experimental: Vitamin D3 100,000 IU;Active Comparator: Vitamin D3 12,000 IU
40 A Study Evaluating the Efficacy and Safety of LentiGlobin BB305 Drug Product in Beta-Thalassemia Major and Sickle Cell Disease Active, not recruiting NCT02151526 Phase 1, Phase 2
41 Feasibility Study of Unfractionated Heparin in Acute Chest Syndrome Terminated NCT02098993 Phase 2 Unfractionated heparin
42 A Study of Varespladib Infusion in Subjects With Sickle Cell Disease. Terminated NCT01522196 Phase 2 Varespladib
43 Treatment of Adult Patients With Hemoglobin SC Disease (SCYTHE) Terminated NCT02640573 Phase 2 Hydroxyurea
44 Hydroxyurea and Magnesium Pidolate to Treat People With Hemoglobin Sickle Cell Disease Terminated NCT00532883 Phase 2 Hydroxyurea;Magnesium Pidolate
45 Evaluation of Different Dose Regimens of Aes-103 Given for 28 Days to Subjects With Stable Sickle Cell Disease Terminated NCT01987908 Phase 2 Aes-103
46 Macrolide Therapy to Improve Forced Expiratory Volume in 1 Second in Adults With Sickle Cell Disease Withdrawn NCT02960503 Phase 1, Phase 2 Azithromycin
47 Phase 2 Study of MP4CO to Treat Vaso-occlusive Sickle Crisis Withdrawn NCT01925001 Phase 2 MP4CO;Sodium chloride solution
48 A Phase 1 Study of Continuous Intravenous L-citrulline During Sickle Cell Pain Crisis or Acute Chest Syndrome Unknown status NCT02697240 Phase 1 Intravenous citrulline
49 Inhaled Corticosteroid Use to Prevent Acute Chest Syndrome Recurrence in Children Between 1 and 4 With Sickle Cell Disease: a Feasibility Trial Completed NCT02187445 Phase 1 Budesonide inhalation suspension
50 Pilot and Feasibility Trial of Plerixafor for Hematopoietic Stem Cell (HSC) Mobilization in Patients With Sickle Cell Disease Pilot and Feasibility Trial of Plerixafor for Hematopoietic Stem Cell (HSC) Mobilization in Patients With Sickle Cell Disease Completed NCT02989701 Phase 1 Plerixafor

Search NIH Clinical Center for Acute Chest Syndrome

Cochrane evidence based reviews: acute chest syndrome

Genetic Tests for Acute Chest Syndrome

Anatomical Context for Acute Chest Syndrome

MalaCards organs/tissues related to Acute Chest Syndrome:

42
Lung, Bone, Bone Marrow, Endothelial, Kidney, Monocytes, Placenta

Publications for Acute Chest Syndrome

Articles related to Acute Chest Syndrome:

(show top 50) (show all 278)
# Title Authors Year
1
Management of an adult patient with sickle cell disease and acute chest syndrome by veno-venous extracorporeal membrane oxygenation. ( 30643938 )
2019
2
Successful Treatment of Acute Chest Syndrome with Manual Exchange Transfusion in a Patient with Sickle Beta+-thalassemia. ( 30713307 )
2019
3
Low-risk factors for severe bacterial infection and acute chest syndrome in children with sickle cell disease. ( 30740900 )
2019
4
Extracorporeal Life Support for Severe Acute Chest Syndrome in Adult Sickle Cell Disease: A Preliminary Report. ( 30768514 )
2019
5
Misdiagnosis: Acute Chest Syndrome That Evolved into Acute Respiratory Distress Syndrome in a Patient without a Documented History of Hemoglobinopathy. ( 30853992 )
2019
6
Candida albicans induced acute chest syndrome in sickle cell disease. ( 30900797 )
2019
7
Acute Chest Syndrome Progressing to ARDS in a Patient of 25-Week Gestation. ( 29666710 )
2018
8
Early Noninvasive Ventilation and Nonroutine Transfusion for Acute Chest Syndrome in Sickle Cell Disease in Children: A Descriptive Study. ( 29356722 )
2018
9
Successful Use of Veno-Venous Extracorporeal Membrane Oxygenation in an Adult Patient with Sickle Cell Anemia and Severe Acute Chest Syndrome. ( 29633667 )
2018
10
Augmented NRF2 activation protects adult sickle mice from lethal acute chest syndrome. ( 29923176 )
2018
11
Early initiation of inhaled corticosteroids does not decrease acute chest syndrome morbidity in pediatric patients with sickle cell disease. ( 29550053 )
2018
12
Acute chest syndrome among children hospitalized with vaso-occlusive crisis: A nationwide study in the United States. ( 29134776 )
2018
13
Comprehensive management reduces incidence and mortality of acute chest syndrome in patients with sickle cell disease. ( 29205462 )
2018
14
Factors Associated With Mechanical Ventilation Use in Children With Sickle Cell Disease and Acute Chest Syndrome. ( 29923940 )
2018
15
The McConnell Sign is Seen in Patients With Acute Chest Syndrome. ( 29498079 )
2018
16
Recurrent Acute Chest Syndrome in Pediatric Sickle Cell Disease: Clinical Features and Risk Factors. ( 29200151 )
2018
17
Acute chest syndrome in sickle cell disease. ( 29648482 )
2018
18
Aeroallergen sensitization predicts acute chest syndrome in children with sickle cell anaemia. ( 29363738 )
2018
19
Bedside ultrasound as a predictive tool for acute chest syndrome in sickle cell patients. ( 30017686 )
2018
20
Limited Exchange Transfusion Can Be Very Beneficial in Sickle Cell Anemia with Acute Chest Syndrome: A Case Report from Tanzania. ( 30034890 )
2018
21
Children with HbSβ0 thalassemia have higher hemoglobin levels and lower incidence rate of acute chest syndrome compared to children with HbSS. ( 30094930 )
2018
22
Bronchodilator Use for Acute Chest Syndrome Among Large Pediatric Hospitals in North America. ( 30173539 )
2018
23
Acute chest syndrome in sickle cell anaemia: higher serum levels of interleukin-8 and highly sensitive C-reactive proteins are associated with impaired lung function. ( 30295174 )
2018
24
Association of plasma CD40L with acute chest syndrome in sickle cell anemia. ( 28609750 )
2017
25
Extracorporeal Lung Support in Acute Chest Syndrome Associated With Sickle Cell Disease: A Rare Report of a Common Case. ( 28703372 )
2017
26
Association of Guideline-Adherent Antibiotic Treatment With Readmission of Children With Sickle Cell Disease Hospitalized With Acute Chest Syndrome. ( 28892533 )
2017
27
Exosomes contribute to endothelial integrity and acute chest syndrome risk: Preliminary findings. ( 28486752 )
2017
28
Plastic bronchitis: An unusual complication of acute chest syndrome in adult. ( 28443234 )
2017
29
Acute Splenic Sequestration Crisis After Red Blood Cell Exchange for Acute Chest Syndrome in an Adult With Sickle I^-Thalassemia: What Went Wrong? ( 29205801 )
2017
30
Inflammatory and endothelial markers during vaso-occlusive crisis and acute chest syndrome in sickle cell disease. ( 28741692 )
2017
31
A clinical risk score for pulmonary artery thrombosis during acute chest syndrome in adult patients with sickle cell disease. ( 28905364 )
2017
32
Acute Chest Syndrome in Children with Sickle Cell Disease. ( 29279787 )
2017
33
Accuracy of Point-of-Care Lung Ultrasonography for Diagnosis of Acute Chest Syndrome in Pediatric Patients with Sickle Cell Disease and Fever. ( 27155438 )
2016
34
Rapidly progressive acute chest syndrome in individuals with sickle cell anemia. ( 27543812 )
2016
35
Inhaled bronchodilators for acute chest syndrome in people with sickle cell disease. ( 27673392 )
2016
36
Rare Case of Posterior Reversible Leukoencephalopathy Syndrome Secondary to Acute Chest Syndrome. ( 27957377 )
2016
37
Score Predicting Acute Chest Syndrome During Vaso-occlusive Crises in Adult Sickle-cell Disease Patients. ( 27412264 )
2016
38
Original Research: Acute chest syndrome in sickle cell disease: Effect of genotype and asthma. ( 26936083 )
2016
39
Sickle cell crisis - Acute chest syndrome. ( 27728299 )
2016
40
Bedside Lung Ultrasound During Acute Chest Syndrome in Sickle Cell Disease. ( 26886600 )
2016
41
Effect of automated red cell exchanges on oxygen saturation on-air, blood parameters and length of hospitalization in sickle cell disease patients with acute chest syndrome. ( 27397962 )
2016
42
Are We Missing the Mark? Fever, Respiratory Symptoms, Chest Radiographs and Acute Chest Syndrome in Sickle Cell Disease. ( 27153121 )
2016
43
Blood transfusions for treating acute chest syndrome in people with sickle cell disease. ( 27574910 )
2016
44
Prevalence of acute kidney injury during pediatric admissions for acute chest syndrome. ( 27011218 )
2016
45
Acute Chest Syndrome, Asthma, and Lung Function in Sickle Cell Disease. Which Is the Chicken, and Which Is the Egg? ( 27509149 )
2016
46
The intersection between asthma and acute chest syndrome in children with sickle-cell anaemia. ( 27353685 )
2016
47
Extracorporeal membrane oxygenation for the treatment of adult sickle cell acute chest syndrome. ( 26130498 )
2015
48
Platelets Decline during Vaso-Occlusive Crisis as a Predictor of Acute Chest Syndrome in Sickle Cell Disease. ( 26453077 )
2015
49
Increased risk of severe vaso-occlusive episodes after initial acute chest syndrome in children with sickle cell anemia less than 4 years old: Sleep and asthma cohort. ( 25619382 )
2015
50
Hashimoto's thyroiditis and acute chest syndrome revealing sickle cell anemia in a 32 years female patient. ( 26327979 )
2015

Variations for Acute Chest Syndrome

Expression for Acute Chest Syndrome

Search GEO for disease gene expression data for Acute Chest Syndrome.

Pathways for Acute Chest Syndrome

GO Terms for Acute Chest Syndrome

Cellular components related to Acute Chest Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 CD40LG CXCL8 EDN1 HBB PLA2G10 PTX3
2 extracellular space GO:0005615 9.17 CD40LG CXCL8 EDN1 HBB PLA2G10 PTX3
3 tertiary granule lumen GO:1904724 9.16 HBB PTX3

Biological processes related to Acute Chest Syndrome according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.61 EDN1 NOS3 VCAM1
2 cellular response to tumor necrosis factor GO:0071356 9.58 CXCL8 EDN1 VCAM1
3 positive regulation of T cell proliferation GO:0042102 9.51 CD40LG VCAM1
4 response to nicotine GO:0035094 9.49 EDN1 VCAM1
5 leukocyte cell-cell adhesion GO:0007159 9.48 CD40LG VCAM1
6 positive regulation of neutrophil chemotaxis GO:0090023 9.46 CXCL8 EDN1
7 regulation of blood pressure GO:0008217 9.43 EDN1 HBB NOS3
8 positive regulation of prostaglandin secretion GO:0032308 9.37 EDN1 PLA2G10
9 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.32 EDN1 NOS3
10 nitric oxide transport GO:0030185 9.16 EDN1 HBB
11 positive regulation of nitric oxide biosynthetic process GO:0045429 9.13 EDN1 HBB PTX3
12 regulation of blood vessel size GO:0050880 8.8 EDN1 HBB NOS3

Molecular functions related to Acute Chest Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADP binding GO:0050661 8.96 G6PD NOS3
2 cytokine activity GO:0005125 8.8 CD40LG CXCL8 EDN1

Sources for Acute Chest Syndrome

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