MCID: ACT017
MIFTS: 50

Acute Chest Syndrome

Categories: Cardiovascular diseases, Respiratory diseases

Aliases & Classifications for Acute Chest Syndrome

MalaCards integrated aliases for Acute Chest Syndrome:

Name: Acute Chest Syndrome 12 54 44 15 17 70
Acute Chest Syndrome in Sickle Cell Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1584
ICD9CM 34 517.3
MeSH 44 D056586
NCIt 50 C138179
SNOMED-CT 67 372146004
UMLS 70 C0742343

Summaries for Acute Chest Syndrome

Disease Ontology : 12 A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. The crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion. The disease has symptom fever, has symptom pleuritic chest pain, has symptom tachypnea, has symptom cough, has symptom hypoxemia, has symptom marked leukocytosis, and has symptom diffuse infiltrates on chest radiograph.

MalaCards based summary : Acute Chest Syndrome, also known as acute chest syndrome in sickle cell disease, is related to sickle cell disease and hemoglobinopathy, and has symptoms including fever, cough and tachypnea. An important gene associated with Acute Chest Syndrome is NOS3 (Nitric Oxide Synthase 3), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Heparin and Dalteparin have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and endothelial, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 73 The acute chest syndrome is a vaso-occlusive crisis of the pulmonary vasculature commonly seen in people... more...

Related Diseases for Acute Chest Syndrome

Diseases related to Acute Chest Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 245)
# Related Disease Score Top Affiliating Genes
1 sickle cell disease 31.1 VCAM1 THBS1 PLA2G10 NOS3 HMOX1 HBB
2 hemoglobinopathy 30.2 VEGFA VCAM1 HBB G6PD
3 rheumatic heart disease 30.0 VCAM1 HLA-DRB1 HLA-DQB1
4 pneumonia 30.0 HMOX1 CXCL8 CSF3 CD40LG
5 pulmonary hypertension 29.9 VEGFA NOS3 HMOX1 EDN1 CXCL8
6 pulmonary edema 29.9 NOS3 HMOX1 EDN1 CXCL8 CSF3
7 sleep apnea 29.8 VEGFA VCAM1 NOS3 EDN1 CXCL8
8 sickle cell anemia 29.6 VCAM1 NOS3 HMOX1 HLA-DRB1 HBB G6PD
9 ischemia 29.5 VEGFA NOS3 NOS1 HMOX1 EDN1
10 respiratory failure 29.5 VEGFA PTX3 IL1A G6PD EDN1 CXCL8
11 lung disease 29.2 VEGFA IL1A HMOX1 EDN1 CXCL8 CSF3
12 bacterial infectious disease 29.0 PTX3 IL1A CXCL8 CSF3
13 thrombocytopenia 28.9 THBS1 IL1A EDN1 CXCL8 CSF3 CD40LG
14 hemolytic anemia 28.6 IL1A HMOX1 HBB G6PD CSF3 CD40LG
15 asthma 28.2 VCAM1 PLA2G2A NOS1 IL1A HLA-DRB1 HLA-DQB1
16 sickle cell - hemoglobin d disease 11.0
17 deficiency anemia 10.5
18 thalassemia 10.4
19 achalasia, familial esophageal 10.4 NOS1 HLA-DQB1
20 limbic encephalitis with lgi1 antibodies 10.4 HLA-DRB1 HLA-DQB1
21 autoimmune polyglandular syndrome type 3 10.4 HLA-DRB1 HLA-DQB1
22 pemphigoid 10.4 HLA-DRB1 HLA-DQB1
23 idiopathic hypersomnia 10.4 HLA-DRB1 HLA-DQB1
24 hypersomnia 10.4 HLA-DRB1 HLA-DQB1
25 narcolepsy 2 10.4 HLA-DRB1 HLA-DQB1
26 htlv-1 associated myelopathy/tropical spastic paraparesis 10.3 HLA-DRB1 HLA-DQB1
27 latent autoimmune diabetes in adults 10.3 HLA-DRB1 HLA-DQB1
28 occupational asthma 10.3 HLA-DRB1 HLA-DQB1
29 adult respiratory distress syndrome 10.3
30 primary adrenal insufficiency 10.3 HLA-DRB1 HLA-DQB1
31 recurrent respiratory papillomatosis 10.3 HLA-DRB1 HLA-DQB1
32 beryllium disease 10.3 HLA-DRB1 HLA-DQB1
33 apple allergy 10.3 HLA-DRB1 HLA-DQB1
34 chronic beryllium disease 10.3 HLA-DRB1 HLA-DQB1
35 metal allergy 10.3 HLA-DRB1 HLA-DQB1
36 autoimmune hepatitis type 1 10.3 HLA-DRB1 HLA-DQB1
37 focal epithelial hyperplasia 10.3 HLA-DRB1 HLA-DQB1
38 pediatric multiple sclerosis 10.3 HLA-DRB1 HLA-DQB1
39 engraftment syndrome 10.3 CXCL8 CSF3
40 impotence 10.3 NOS3 NOS1 EDN1
41 podoconiosis 10.3 HLA-DRB1 HLA-DQB1
42 mycobacterium abscessus 10.3 HMOX1 CXCL8
43 actinic prurigo 10.2 VCAM1 HLA-DRB1
44 hemifacial spasm 10.2 VEGFA NOS3
45 rheumatoid vasculitis 10.2 VCAM1 HLA-DRB1
46 kidney papillary necrosis 10.2 HBB EDN1
47 mumps 10.2 HLA-DRB1 HLA-DQB1 CXCL8
48 sclerosing cholangitis 10.2 HLA-DRB1 HLA-DQB1 CXCL8
49 plantar fasciitis 10.2 VEGFA NOS3
50 primary progressive multiple sclerosis 10.2 VCAM1 HLA-DRB1 HLA-DQB1

Graphical network of the top 20 diseases related to Acute Chest Syndrome:



Diseases related to Acute Chest Syndrome

Symptoms & Phenotypes for Acute Chest Syndrome

Symptoms:

12
  • fever
  • cough
  • tachypnea
  • hypoxemia
  • pleuritic chest pain
  • marked leukocytosis
  • diffuse infiltrates on chest radiograph

UMLS symptoms related to Acute Chest Syndrome:


dyspnea; hemoptysis; apnea; cheyne-stokes respiration; coughing; hoarseness

MGI Mouse Phenotypes related to Acute Chest Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.23 CD40LG EDN1 G6PD HLA-DQB1 HMOX1 IL1A
2 hematopoietic system MP:0005397 10.18 CD40LG CSF3 G6PD HLA-DQB1 HMOX1 IL1A
3 cellular MP:0005384 10.17 CD40LG G6PD HLA-DQB1 HMOX1 NOS1 NOS3
4 endocrine/exocrine gland MP:0005379 10.1 CD40LG EDN1 HLA-DQB1 HMOX1 NOS1 NOS3
5 immune system MP:0005387 10.1 CD40LG CSF3 HLA-DQB1 HMOX1 IL1A NOS1
6 muscle MP:0005369 9.86 EDN1 HLA-DQB1 HMOX1 NOS1 NOS3 PLA2G10
7 renal/urinary system MP:0005367 9.81 CD40LG CSF3 EDN1 HLA-DQB1 HMOX1 NOS1
8 reproductive system MP:0005389 9.65 CD40LG HLA-DQB1 HMOX1 NOS1 NOS3 PLA2G10
9 respiratory system MP:0005388 9.17 HLA-DQB1 HMOX1 NOS1 NOS3 PTX3 THBS1

Drugs & Therapeutics for Acute Chest Syndrome

Drugs for Acute Chest Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 68)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 3 9005-49-6 772 9812414
2
Dalteparin Approved Phase 3 9005-49-6
3
Tinzaparin Approved Phase 3 9041-08-1, 9005-49-6 25244225
4
Nitric Oxide Approved Phase 2, Phase 3 10102-43-9 145068
5
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
6
Atorvastatin Approved Phase 3 134523-00-5 60823
7
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
8
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
9 Anticoagulants Phase 3
10 Fibrinolytic Agents Phase 3
11 calcium heparin Phase 3
12 Heparin, Low-Molecular-Weight Phase 3
13 Neurotransmitter Agents Phase 2, Phase 3
14 Anti-Asthmatic Agents Phase 2, Phase 3
15 Respiratory System Agents Phase 2, Phase 3
16 Bronchodilator Agents Phase 2, Phase 3
17 Vasodilator Agents Phase 2, Phase 3
18 Antioxidants Phase 2, Phase 3
19 Endothelium-Dependent Relaxing Factors Phase 2, Phase 3
20 Protective Agents Phase 2, Phase 3
21 Analgesics, Non-Narcotic Phase 3
22 Cyclooxygenase Inhibitors Phase 3
23 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 3
24 Anticholesteremic Agents Phase 3
25 Analgesics Phase 3
26 Antimetabolites Phase 3
27 Antirheumatic Agents Phase 3
28 Lipid Regulating Agents Phase 3
29 Antipyretics Phase 3
30 Anti-Inflammatory Agents, Non-Steroidal Phase 3
31 Hypolipidemic Agents Phase 3
32 Hormones Phase 3
33 Anti-Inflammatory Agents Phase 3
34 Hormone Antagonists Phase 3
35 glucocorticoids Phase 3
36 Gastrointestinal Agents Phase 3
37 Antiemetics Phase 3
38 Antineoplastic Agents, Hormonal Phase 3
39
Defibrotide Approved, Investigational Phase 2 83712-60-1
40
tannic acid Approved Phase 2 1401-55-4
41
Benzocaine Approved, Investigational Phase 2 1994-09-7, 94-09-7 2337
42
Vitamin D3 Approved, Nutraceutical Phase 2 67-97-0 5280795 6221
43
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2 1406-16-2
44
Ergocalciferol Approved, Nutraceutical Phase 2 50-14-6 5280793
45
Varespladib methyl Investigational Phase 2 172733-08-3
46 Trace Elements Phase 2
47 Nutrients Phase 2
48 Vitamins Phase 2
49 Vitamin D2 Phase 2
50 Ergocalciferols Phase 2

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 A Prospective, Randomized, Double-blind, Placebo Controlled, Multi-national Study of Therapeutic Anticoagulation Strategy for Acute Chest Syndrome in Adults Unknown status NCT02580773 Phase 3 Prophylactic anticoagulation ( INNOHEP®);Curative anticoagulation ( INNOHEP®)
2 Bicentric Study of the Effect of Inhaled Nitric Oxide Compared to Placebo in Acute Chest Syndrome of Adult Sickle Cell Patients Completed NCT00748423 Phase 2, Phase 3 Nitric Oxide;Placebo
3 Investigator-initiated, Placebo-controlled, Randomized Trial to Assess the Efficacy and Safety of Platelet Inhibition and/ or Lipid Lowering in Non-ACS-patients With Elevated High-sensitivity Troponin Values Recruiting NCT03820466 Phase 3 Aspirin;Atorvastatin;Placebo Aspirin;Placebo Atorvastatin
4 Randomized Trial of Oral Dexamethasone for Acute Chest Syndrome Terminated NCT00530270 Phase 3 Dexamethasone;Placebo
5 Vitamin D for Sickle-cell Respiratory Complications Completed NCT01443728 Phase 2 Experimental: Vitamin D3 100,000 IU;Active Comparator: Vitamin D3 12,000 IU
6 Nitric Oxide Therapy for Acute Chest Syndrome in Sickle Cell Disease Children: Randomized, Double Blind Placebo-controlled Concept-proof Trial Completed NCT01089439 Phase 2 Nitric oxide by inhalation INOMAX;Placebo
7 Arginine Therapy for Acute Chest Syndrome in Sickle Cell Disease Completed NCT00029731 Phase 2 Arginine hydrochloride
8 IMPACTS Trial: Investigation of the Modulation of Phospholipase in Acute Chest Syndrome (Dose Escalation Study: Varespladib Infusion [A-001] for the Prevention of Acute Chest Syndrome in At-Risk Patients With Sickle Cell Disease and Vaso-occlusive Crisis) Completed NCT00434473 Phase 2 A-001
9 Daily Vitamin D for Sickle-cell Respiratory Complications Recruiting NCT04170348 Phase 2 Daily oral vitamin D3, 3,333 IU;Bolus oral vitamin D3, 100,000 IU;Placebo oral tablet
10 A Phase II Study to Determine the Safety of Defibrotide in Sickle Cell Disease-Related Acute Chest Syndrome Active, not recruiting NCT03805581 Phase 2 Defibrotide
11 Unfractionated Heparin in Acute Chest Syndrome: A Pilot Feasibility Randomized Controlled Trial of Unfractionated Heparin vs. Standard of Care in Acute Chest Syndrome Terminated NCT02098993 Phase 2 Unfractionated heparin
12 A Randomized, Double-blind, Placebo-Controlled Study With Varespladib Infusion (A-001) in Subjects With Sickle Cell Disease and Vaso-Occlusive Crisis for the Prevention of Acute Chest Syndrome At-Risk Subjects. Terminated NCT01522196 Phase 2 Varespladib
13 Quantifying the Presence of Lung Disease and Pulmonary Hypertension in Children With Sickle Cell Disease Completed NCT01895998 Phase 1 Albuterol
14 A Phase 1 Dose Escalation Study of Continuous Intravenous L-citrulline During Sickle Cell Pain Crisis or Acute Chest Syndrome Completed NCT02697240 Phase 1 Intravenous citrulline
15 Inhaled Corticosteroid Use to Prevent Acute Chest Syndrome Recurrence in Children Between 1 and 4 With Sickle Cell Disease: a Feasibility Trial Completed NCT02187445 Phase 1 Budesonide inhalation suspension
16 A Pilot Study of Azithromycin Prophylaxis for Acute Chest Syndrome in Sickle Cell Disease Withdrawn NCT02630394 Phase 1 Azithromycin
17 Validation of a Predictive Score of Acute Chest Syndrome Unknown status NCT03032055
18 Utility of the Cardiac Electrical Biomarker in Patients With Ischaemic Heart Disease Unknown status NCT03498105
19 Secretory Phospholipases A2 in Exhaled Breath Condensate From Sickle Cell Patients With Acute Chest Syndrome: A Feasibility Study Completed NCT03250585
20 Epidemiology and Pathophysiological Mechanisms of Pulmonary Arterial Hypertension in SS and SC Children in Martinique and Guadeloupe.Three Years Follow up of a Cohort of Children Aged From 8 to 16 Years Old Completed NCT03368261
21 ST Elevation (Acute Coronary Syndrome Versus Pericarditis;Could Measurement of Lp-associated PLA2 -a Vascular Specific Marker of Inflammation- be Helpful to the Clinician? Completed NCT01041339
22 Role of Placenta Growth Factor in Sickle Acute Chest Syndrome Completed NCT00448370
23 Preventing Acute Chest Syndrome by Transfusion Feasibility Study( PROACTIVE Feasibility Study) Completed NCT00951808
24 Combined Use of a Respiratory Broad Panel Multiplex PCR and Procalcitonin to Reduce Antibiotics Exposure in Adult Patients With Sickle-cell Disease Hospitalized for Acute Chest Syndrome. A Bi-centric, Open, Parallel-group, Randomized Controlled Study Recruiting NCT03919266
25 Early Diagnosis of Sickle Acute Chest Syndrome Using a Combination of Plasma Biomarkers and Chest Imaging Active, not recruiting NCT03478917
26 Non Invasive Positive Pressure Ventilation for Prevention of Acute Chest Syndrome in Sickle Cell Disease With Vaso-occlusive Crisis and Morphinic Treatment Terminated NCT01501643
27 Early Bi-Level Positive Airway Pressure (BiPAP) Ventilation for Acute Chest Syndrome (ACS) - a Double-Blind Randomized Controlled Pilot Study Terminated NCT01589926

Search NIH Clinical Center for Acute Chest Syndrome

Cochrane evidence based reviews: acute chest syndrome

Genetic Tests for Acute Chest Syndrome

Anatomical Context for Acute Chest Syndrome

MalaCards organs/tissues related to Acute Chest Syndrome:

40
Lung, Bone, Endothelial, Bone Marrow, Placenta, Kidney, Neutrophil

Publications for Acute Chest Syndrome

Articles related to Acute Chest Syndrome:

(show top 50) (show all 1071)
# Title Authors PMID Year
1
Physician-diagnosed asthma and acute chest syndrome: associations with NOS polymorphisms. 61 54
17351927 2007
2
ET-1 and ecNOS gene polymorphisms andsusceptibility to acute chest syndrome and painful vaso-occlusive crises in children with sickle cell anemia. 54 61
16956834 2006
3
Elevated plasma sVCAM-1 levels in children with sickle cell disease: impact of chronic transfusion therapy. 61 54
15114598 2004
4
Sera of patients suffering from inflammatory diseases contain group IIA but not group V phospholipase A(2). 61 54
11040450 2000
5
Red cell transfusion and alloimmunization in sickle cell disease. 61
33792218 2021
6
Ultrasound-guided recruitment maneuvers in pediatric acute chest syndrome due to sickle cell disease. 61
31331675 2021
7
Acute chest syndrome in pediatric sickle cell disease: Associations with racial composition and neighborhood deprivation. 61
33405365 2021
8
Vasculopathy in Sickle Cell Disease: From Red Blood Cell Sickling to Vascular Dysfunction. 61
33792905 2021
9
Mortality in sickle cell disease: A population-based study in an aboriginal community in the Gudalur Valley, Nilgiris, Tamil Nadu, India. 61
33381914 2021
10
Infectious aetiologies of severe acute chest syndrome in sickle-cell adult patients, combining conventional microbiological tests and respiratory multiplex PCR. 61
33649379 2021
11
Abdominal Manifestations of Sickle Cell Disease. 61
32564896 2021
12
Dual-energy CT evidence of pulmonary microvascular occlusion in patients with sickle cell disease experiencing acute chest syndrome. 61
33773449 2021
13
Insights image for "Circulating extracellular vesicles from patients with acute chest syndrome disrupt adherens junctions between endothelial cells". 61
33790407 2021
14
Opioids are not a major cause of death of patients with sickle cell disease. 61
33758998 2021
15
Maternal and perinatal outcomes in pregnant women with sickle cell disease: an update. 61
33716021 2021
16
Pregnancy Outcome In Homozygous Sickle Cell Disease: Observations From The Jamaican Birth Cohort. 61
33683802 2021
17
Longitudinal Assessment of Retinal Thinning in Adults With and Without Sickle Cell Retinopathy Using Spectral-Domain Optical Coherence Tomography. 61
33538815 2021
18
Long Term Tolerability of Sildenafil in Sickle Cell Disease. 61
33650125 2021
19
Post-traumatic cerebral fat embolism syndrome with a favourable outcome: a case report. 61
33602171 2021
20
Primary prevention of stroke in children with sickle cell anemia in sub-Saharan Africa: rationale and design of phase III randomized clinical trial. 61
33236662 2021
21
Clinical presentations and outcomes of COVID-19 infection in sickle cell disease patients: Case series from Komfo Anokye teaching hospital, Ghana. 61
33598289 2021
22
The burden of obstructive sleep apnea in pediatric sickle cell disease: a Kids' inpatient database study. 61
32835382 2021
23
Nocturnal hypoxemia measured by polysomnogram is associated with acute chest syndrome in pediatric sickle cell disease. 61
33006312 2021
24
Severe Acute Chest Syndrome in a Sickle Cell Patient That Required Repeated Exchange Transfusion. 61
33680608 2021
25
Hyperhemolysis Syndrome in a Patient with Sickle Cell Disease: A Case Report. 61
33560964 2021
26
Non-invasive ventilation in pediatric acute chest syndrome: a preliminary two-center prospective observational study. 61
33300327 2021
27
Definity, an affinity for painful crisis: a case series describing vaso-occlusive pain crises in sickle cell patients undergoing echocardiogram with Definity contrast. 61
33598623 2021
28
Streptococcus pneumoniae and Its Virulence Factors H2O2 and Pneumolysin Are Potent Mediators of the Acute Chest Syndrome in Sickle Cell Disease. 61
33671422 2021
29
Krüppel-like factor 1 (KLF1) gene single nucleotide polymorphisms in sickle cell disease and its association with disease-related morbidities. 61
33388857 2021
30
Management of Sickle Cell Disease Complications Beyond Acute Chest Syndrome. 61
33658881 2021
31
ADAMTS13 and von Willebrand factor assessment in steady state and acute vaso-occlusive crisis of sickle cell disease. 61
33537544 2021
32
Nonsurgical Management of Acute Appendicitis in Sickle Cell Disease. 61
32134840 2021
33
The burden of respiratory syncytial virus infections among children with sickle cell disease. 61
33034160 2021
34
Sickle Hepatopathy. 61
33679049 2021
35
BEHAVIORAL CHARACTERISTICS OF CHILDREN WITH SICKLE CELL DISEASE. 61
32785431 2021
36
Clinical predictors of poor outcomes in patients with sickle cell disease and COVID-19 infection. 61
33570644 2021
37
Acute chest syndrome and COVID-19 in sickle cell disease pediatric patients. 61
33363267 2021
38
Risk Factors and Complications Among Pediatric Patients With Sickle Cell Anemia: A Single Tertiary Center Retrospective Study. 61
33552759 2021
39
Hemoglobinopathy and pediatrics in the time of COVID-19. 61
33289008 2021
40
Hyperhemolysis Syndrome in a Patient With Sickle Cell Disease and Acute Chest Syndrome. 61
33659145 2021
41
Characteristics and risk factors associated with critical illness in pediatric COVID-19. 61
33340348 2020
42
COVID-19 Infection and Acute Pulmonary Embolism in an Adolescent Female With Sickle Cell Disease. 61
33520543 2020
43
IL-6 levels are dramatically high in the sputum from children with sickle cell disease during acute chest syndrome. 61
33351109 2020
44
Hemoglobin Target and Transfusion Modality for Adult Patients With Sickle Cell Disease Acute Chest Syndrome. 61
33307945 2020
45
Splenectomy in Jamaican children with sickle cell disease: Outcome of selective blood transfusion. 61
33241734 2020
46
Acute chest syndrome in the setting of SARS-COV-2 infections-A case series at an urban medical center in the Bronx. 61
32893954 2020
47
Procalcitonin to Reduce Antibiotic Exposure during Acute Chest Syndrome in Adult Patients with Sickle-Cell Disease. 61
33228148 2020
48
Unfractionated heparin in acute chest syndrome: a pilot feasibility randomized controlled trial of unfractionated heparin vs. standard of care in acute chest syndrome. 61
33292674 2020
49
Gap Junctions between Endothelial Cells Are Disrupted by Circulating Extracellular Vesicles from Sickle Cell Patients with Acute Chest Syndrome. 61
33255173 2020
50
The association between hydroxyurea adherence and opioid utilization among Texas Medicaid enrollees with sickle cell disease. 61
33119448 2020

Variations for Acute Chest Syndrome

Expression for Acute Chest Syndrome

Search GEO for disease gene expression data for Acute Chest Syndrome.

Pathways for Acute Chest Syndrome

Pathways related to Acute Chest Syndrome according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.81 VEGFA VCAM1 PTX3 PLA2G2A NOS3 NOS1
2
Show member pathways
13.59 PLA2G2A NOS3 NOS1 IL1A EDN1 CXCL8
3
Show member pathways
13.22 VEGFA VCAM1 IL1A HMOX1 HLA-DRB1 HLA-DQB1
4
Show member pathways
12.71 VEGFA IL1A HLA-DRB1 HLA-DQB1 CXCL8 CD40LG
5
Show member pathways
12.4 PLA2G2A PLA2G10 NOS3 EDN1
6
Show member pathways
12.38 NOS3 NOS1 HMOX1 CXCL8
7
Show member pathways
12.18 IL1A HLA-DRB1 HLA-DQB1 CD40LG
8 12.06 THBS1 NOS1 HLA-DRB1 HLA-DQB1
9 12.04 VCAM1 HLA-DRB1 HLA-DQB1 CD40LG
10 11.93 PLA2G2A NOS1 IL1A CXCL8
11 11.89 VEGFA VCAM1 IL1A HMOX1 CXCL8
12 11.85 THBS1 IL1A CXCL8
13 11.85 VEGFA NOS3 HMOX1 EDN1
14 11.84 VCAM1 CXCL8 CD40LG
15 11.78 VEGFA VCAM1 NOS3 IL1A HMOX1 EDN1
16 11.77 IL1A HLA-DRB1 HLA-DQB1 CSF3
17 11.77 VEGFA IL1A HLA-DRB1 HLA-DQB1 CXCL8
18 11.75 THBS1 NOS3 HMOX1
19 11.66 VEGFA THBS1 CXCL8
20 11.59 VEGFA HMOX1 EDN1
21
Show member pathways
11.52 VEGFA VCAM1 IL1A CXCL8 CD40LG
22 11.5 VEGFA NOS3 EDN1
23 11.45 IL1A CXCL8 CSF3
24 11.45 PTX3 HMOX1 EDN1 CXCL8 CSF3
25 11.43 VEGFA VCAM1 NOS3 IL1A EDN1 CXCL8
26 11.27 NOS3 HMOX1 CXCL8
27 11.17 IL1A HLA-DRB1 CSF3
28 11.15 PLA2G2A NOS3 NOS1
29 10.8 VCAM1 THBS1 HBB CXCL8 CSF3 CD40LG
30 10.75 NOS3 NOS1
31 10.51 NOS3 NOS1

GO Terms for Acute Chest Syndrome

Cellular components related to Acute Chest Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.72 VEGFA VCAM1 THBS1 HLA-DRB1 CD40LG
2 extracellular region GO:0005576 9.7 VEGFA THBS1 PTX3 PLA2G2A PLA2G10 IL1A
3 extracellular space GO:0005615 9.47 VEGFA VCAM1 THBS1 PTX3 PLA2G2A PLA2G10
4 secretory granule GO:0030141 9.43 VEGFA THBS1 PLA2G2A
5 endocytic vesicle membrane GO:0030666 9.33 NOS3 HLA-DRB1 HLA-DQB1

Biological processes related to Acute Chest Syndrome according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.85 VCAM1 NOS3 NOS1 EDN1
2 inflammatory response GO:0006954 9.85 THBS1 PTX3 PLA2G2A IL1A CXCL8 CD40LG
3 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.81 VEGFA NOS1 CSF3
4 cellular response to tumor necrosis factor GO:0071356 9.8 VCAM1 THBS1 EDN1 CXCL8
5 interferon-gamma-mediated signaling pathway GO:0060333 9.79 VCAM1 HLA-DRB1 HLA-DQB1
6 positive regulation of endothelial cell migration GO:0010595 9.78 VEGFA THBS1 EDN1
7 positive regulation of smooth muscle cell proliferation GO:0048661 9.77 THBS1 HMOX1 EDN1
8 cellular response to heat GO:0034605 9.73 THBS1 IL1A HMOX1
9 cytokine-mediated signaling pathway GO:0019221 9.73 VEGFA VCAM1 IL1A HMOX1 CXCL8 CSF3
10 positive regulation of blood vessel endothelial cell migration GO:0043536 9.71 VEGFA THBS1 NOS3
11 positive regulation of nitric oxide biosynthetic process GO:0045429 9.7 PTX3 HBB EDN1
12 immune response GO:0006955 9.7 THBS1 IL1A HLA-DRB1 HLA-DQB1 CXCL8 CSF3
13 induction of positive chemotaxis GO:0050930 9.64 VEGFA CXCL8
14 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.64 HLA-DRB1 HLA-DQB1
15 positive regulation of guanylate cyclase activity GO:0031284 9.63 NOS3 NOS1
16 positive regulation of prostaglandin secretion GO:0032308 9.62 PLA2G10 EDN1
17 chronic inflammatory response GO:0002544 9.62 VCAM1 THBS1
18 regulation of blood pressure GO:0008217 9.62 NOS3 HMOX1 HBB EDN1
19 response to nicotine GO:0035094 9.61 VCAM1 HMOX1 EDN1
20 arginine catabolic process GO:0006527 9.6 NOS3 NOS1
21 phosphatidic acid metabolic process GO:0046473 9.58 PLA2G2A PLA2G10
22 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.58 NOS3 EDN1
23 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.57 HLA-DRB1 HLA-DQB1
24 phosphatidylethanolamine metabolic process GO:0046337 9.51 PLA2G2A PLA2G10
25 nitric oxide transport GO:0030185 9.48 HBB EDN1
26 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.46 HLA-DRB1 HLA-DQB1
27 response to hypoxia GO:0001666 9.43 VEGFA VCAM1 THBS1 NOS1 HMOX1 EDN1
28 smooth muscle hyperplasia GO:0014806 9.4 NOS3 HMOX1
29 positive regulation of angiogenesis GO:0045766 9.1 VEGFA THBS1 NOS3 IL1A HMOX1 CXCL8

Molecular functions related to Acute Chest Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 arginine binding GO:0034618 9.46 NOS3 NOS1
2 heme binding GO:0020037 9.46 NOS3 NOS1 HMOX1 HBB
3 MHC class II receptor activity GO:0032395 9.43 HLA-DRB1 HLA-DQB1
4 NADP binding GO:0050661 9.43 NOS3 NOS1 G6PD
5 NADPH-hemoprotein reductase activity GO:0003958 9.4 NOS3 NOS1
6 cadmium ion binding GO:0046870 9.37 NOS3 NOS1
7 tetrahydrobiopterin binding GO:0034617 9.32 NOS3 NOS1
8 cytokine activity GO:0005125 9.1 VEGFA IL1A EDN1 CXCL8 CSF3 CD40LG
9 nitric-oxide synthase activity GO:0004517 8.96 NOS3 NOS1

Sources for Acute Chest Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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