MCID: ACT036
MIFTS: 39

Acute Cholangitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Acute Cholangitis

MalaCards integrated aliases for Acute Cholangitis:

Name: Acute Cholangitis 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:14271
NCIt 51 C35334
SNOMED-CT 69 6215006
UMLS 74 C0267917

Summaries for Acute Cholangitis

MalaCards based summary : Acute Cholangitis is related to cholangitis and melioidosis. An important gene associated with Acute Cholangitis is TREM1 (Triggering Receptor Expressed On Myeloid Cells 1), and among its related pathways/superpathways are Dendritic Cells Developmental Lineage Pathway and Microglia Activation During Neuroinflammation: Microglia Polarization. The drugs Epinephrine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and heart, and related phenotype is immune system.

Related Diseases for Acute Cholangitis

Diseases in the Cholangitis family:

Acute Cholangitis Chronic Cholangitis

Diseases related to Acute Cholangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 154)
# Related Disease Score Top Affiliating Genes
1 cholangitis 31.7 CRP IL6
2 melioidosis 30.2 IL6 TREM1
3 toxic shock syndrome 30.0 IL6 TREM1
4 obstructive jaundice 29.9 CRP IL6
5 acute cystitis 29.8 CRP IL6
6 bacterial meningitis 29.7 CRP IL6
7 ascending cholangitis 11.2
8 cholecystitis 10.4
9 crimean-congo hemorrhagic fever 10.3 IL6 TREM1
10 choledocholithiasis 10.3
11 bullous impetigo 10.3 CALCA IL6
12 impetigo 10.3 CALCA IL6
13 diabetic foot ulcers 10.3 CALCA IL6
14 pancreatitis 10.2
15 nodular goiter 10.2 CALCA IL6
16 juvenile ankylosing spondylitis 10.2 IL1RN IL6
17 complex regional pain syndrome 10.2 CALCA IL6
18 osteosclerotic myeloma 10.2 IL1RN IL6
19 necrotizing fasciitis 10.2 IL1RN IL6
20 joint disorders 10.2 IL1RN IL6
21 amyloid tumor 10.2 CALCA IL1RN
22 bone resorption disease 10.2 CALCA IL6
23 aphthous stomatitis 10.2 IL1RN IL6
24 idiopathic neutropenia 10.2 IL1RN IL6
25 aseptic meningitis 10.2 CALCA IL1RN
26 cold agglutinin disease 10.2 CRP IL6
27 uremic pruritus 10.2 CRP IL6
28 neutrophilia, hereditary 10.2 CRP IL6
29 spinal disease 10.2 CRP IL6
30 root resorption 10.1 CALCA IL1RN
31 viral pneumonia 10.1 CRP IL6
32 multicentric castleman disease 10.1 CRP IL6
33 castleman disease 10.1 CRP IL6
34 central nervous system vasculitis 10.1 CRP IL6
35 subacute thyroiditis 10.1 CRP IL6
36 intussusception 10.1 CRP IL6
37 louse-borne relapsing fever 10.1 CRP IL6
38 cecal disease 10.1 CRP IL6
39 pyelitis 10.1 CRP IL6
40 ischemic heart disease 10.1 CRP IL6
41 mesenteric lymphadenitis 10.1 CRP IL6
42 viral meningitis 10.1 CRP IL6
43 sepsis in premature infants 10.1 CALCA CRP
44 mycoplasma pneumoniae pneumonia 10.1 CRP IL6
45 hypersensitivity reaction type iii disease 10.1 CRP IL6
46 suppurative cholangitis 10.1 CRP TREM1
47 intermittent explosive disorder 10.1 CRP IL6
48 intermediate coronary syndrome 10.1 CRP IL6
49 suppurative thyroiditis 10.1 CALCA CRP
50 discitis 10.1 CALCA CRP

Graphical network of the top 20 diseases related to Acute Cholangitis:



Diseases related to Acute Cholangitis

Symptoms & Phenotypes for Acute Cholangitis

MGI Mouse Phenotypes related to Acute Cholangitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.1 CRP IL1RN IL6 SBDS THBD TREM1

Drugs & Therapeutics for Acute Cholangitis

Drugs for Acute Cholangitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4,Not Applicable 51-43-4 5816
2
Racepinephrine Approved Phase 4,Not Applicable 329-65-7 838
3 Adrenergic Agonists Phase 4,Not Applicable
4 Bronchodilator Agents Phase 4,Not Applicable
5 Neurotransmitter Agents Phase 4,Not Applicable
6 Adrenergic beta-Agonists Phase 4,Not Applicable
7 Respiratory System Agents Phase 4,Not Applicable
8 Vasoconstrictor Agents Phase 4,Not Applicable
9 Autonomic Agents Phase 4,Not Applicable
10 Epinephryl borate Phase 4,Not Applicable
11 Mydriatics Phase 4,Not Applicable
12 Adrenergic Agents Phase 4,Not Applicable
13 Peripheral Nervous System Agents Phase 4,Not Applicable
14 Anti-Asthmatic Agents Phase 4,Not Applicable
15 Sympathomimetics Phase 4,Not Applicable
16 Adrenergic alpha-Agonists Phase 4,Not Applicable
17
Pentoxifylline Approved, Investigational Early Phase 1 6493-05-6 4740
18
Somatostatin Approved, Investigational Not Applicable 38916-34-6, 51110-01-1 53481605
19
Indomethacin Approved, Investigational Not Applicable 53-86-1 3715
20
Pancrelipase Approved, Investigational Not Applicable 53608-75-6
21
Octreotide Approved, Investigational Not Applicable 83150-76-9 6400441 383414
22
Nitroglycerin Approved, Investigational Not Applicable 55-63-0 4510
23
Scopolamine Approved, Investigational Not Applicable 51-34-3, 6533-68-2 5184
24
Midazolam Approved, Illicit Not Applicable 59467-70-8 4192
25
Meperidine Approved Not Applicable 57-42-1 4058
26
Vitamin A Approved, Nutraceutical, Vet_approved Not Applicable 68-26-8, 22737-96-8, 11103-57-4 9904001 445354
27 Platelet Aggregation Inhibitors Early Phase 1
28 Phosphodiesterase Inhibitors Early Phase 1
29 Radiation-Protective Agents Early Phase 1
30 Free Radical Scavengers Early Phase 1
31 Vasodilator Agents Early Phase 1,Not Applicable
32 Protective Agents Early Phase 1
33 Antioxidants Early Phase 1
34 Anti-Inflammatory Agents Not Applicable
35 Hormones Not Applicable
36 Hormone Antagonists Not Applicable
37 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
38 Ulipristal acetate Not Applicable 126784-99-4
39 Anti-Bacterial Agents Not Applicable
40 Antibiotics, Antitubercular Not Applicable
41 Anti-Infective Agents Not Applicable
42 pancreatin Not Applicable
43 Antitubercular Agents Not Applicable
44 Antineoplastic Agents, Hormonal Not Applicable
45 Gastrointestinal Agents Not Applicable
46 Butylscopolammonium Bromide Not Applicable
47 retinol Not Applicable
48 Retinol palmitate Not Applicable

Interventional clinical trials:

(show all 26)
# Name Status NCT ID Phase Drugs
1 Epinephrine Sprayed on the Papilla for the Prevention of Post-ERCP Pancreatitis Unknown status NCT02839356 Phase 4 epinephrine;normal saline
2 Balloon Catheter vs. Basket Catheter for Endoscopic Bile Duct Stone Extraction Completed NCT02909595 Phase 4
3 Near Infrared Fluorescence Cholangiography (NIRF-C) During Cholecystectomy -- Use in Acute Cholecystitis Sub-Study Completed NCT02070627 Phase 1 Indocyanine Green (ICG)
4 Pentoxifylline for the Prevention of PEP Unknown status NCT02992678 Early Phase 1 Pentoxifylline;Placebo
5 Transient ECG Changes in Patients With Acute Biliary Disease Unknown status NCT01706068
6 The Prophylactic Effect of Stilamin on Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis Unknown status NCT01431781 Not Applicable Stilamin+common daily treatment
7 ENBD After Endoscopic Sphincterotomy Plus Large-balloon Dilation for Preventing PEP Unknown status NCT02830984 Not Applicable
8 The Effect of Different Duration of Bolloon Dilation During ESBD Unknown status NCT02958618 Not Applicable
9 Outcomes of Elderly Patients Admitted to the Intensive Care Unit With Severe Acute Cholangitis Completed NCT03831529
10 Best Biliary Drainage Option in Advanced Klatskin Tumor Completed NCT03104582 Not Applicable
11 Cytological Evaluation of Biliary Epithelium After Endoscopic Sphincterotomy Completed NCT01135732
12 Endoscopic Treatment of Benign Biliary Strictures and Cystic Duct Leakages With a Novel Biodegradable Biliary Stent Completed NCT02353286 Not Applicable
13 Effect of Endoscopic Papillary Balloon Dilation on ERCP Complications Completed NCT02510495 Not Applicable
14 If Different Types of Periampullary Diverticula Affect ERCP Cannulation? Completed NCT03556072
15 The Necessity of Bile Cultures in Patients With Acute Cholangitis Recruiting NCT02601417 Not Applicable
16 Application of Endoscopic Scissors Cutting ENBD Tube in the Treatment of Malignant Hilar Biliary Strictures Recruiting NCT03353181 Not Applicable
17 Effect of 37℃ Non-ionic Contrast Agent During ERCP Procedure in Hilar Cholangiocarcinoma Recruiting NCT03104569 Not Applicable
18 The Comparisons of One-stage and Two-stage Stone Removal in Moderate Cholangitis Recruiting NCT03754491 Not Applicable
19 Short Duration Versus Fourteen Days Antibiotic in Common Bile Duct Cholangitis Recruiting NCT03422042 Not Applicable
20 Effect of Papillary Epinephrine Spraying for the Prevention of Post-ERCP Pancreatitis in Patients Received Octreotide Recruiting NCT03756116 Not Applicable
21 RFA for Malignant Biliary Obstruction Recruiting NCT03166436 Not Applicable
22 Comparison of LCBDE vs ERCP + LC for Choledocholithiasis Recruiting NCT02515474 Not Applicable
23 Long-duration EPBD vs EST for Removal of Biliary Stones Recruiting NCT03683485 Not Applicable
24 A Clinical Trial of Electro-acupuncture for Treating Gallstone Diseases Recruiting NCT03891147 Not Applicable
25 Chinese Registry Study on Treatment of Cholecysto-Choledocholithiasis Active, not recruiting NCT02554097
26 Results of Bile and Blood Culture in Patients With Acute Cholangitis Terminated NCT02107560

Search NIH Clinical Center for Acute Cholangitis

Genetic Tests for Acute Cholangitis

Anatomical Context for Acute Cholangitis

MalaCards organs/tissues related to Acute Cholangitis:

42
Liver, Bone, Heart, Thyroid, Lung, Neutrophil, Myeloid

Publications for Acute Cholangitis

Articles related to Acute Cholangitis:

(show top 50) (show all 303)
# Title Authors Year
1
Acute cholangitis secondary to hydatid membranes in the biliary tract. ( 30176226 )
2019
2
Endoscopic Retrograde Cholangio-Pancreatography-Obtained Bile Culture Can Guide Antibiotic Therapy in Acute Cholangitis. ( 30282078 )
2019
3
Short-Course Antibiotic Treatment Is Not Inferior to a Long-Course One in Acute Cholangitis: A Systematic Review. ( 30368681 )
2019
4
Acute Cholangitis with Atypical Clinical Presentation and Imaging. ( 30392151 )
2019
5
Efficacy of Combined Thrombomodulin and Antithrombin in Anticoagulant Therapy for Acute Cholangitis-induced Disseminated Intravascular Coagulation. ( 30449812 )
2019
6
Saccharomyces cerevisiae fungemia in a critically ill patient with acute cholangitis and long term probiotic use. ( 30505677 )
2019
7
Efficacy and safety of early cholecystectomy for comorbid acute cholecystitis and acute cholangitis: Retrospective cohort study. ( 30581570 )
2019
8
Early vs late endoscopic retrograde cholangiopancreatography in patients with acute cholangitis: A nationwide analysis. ( 30705731 )
2019
9
Upper gastrointestinal hemorrhage is associated with poor outcomes among patients with acute cholangitis: a nationwide analysis. ( 30741727 )
2019
10
Unchanged mortality in patients with acute cholangitis despite an increase in malignant etiologies - a 25-year epidemiological study. ( 30946608 )
2019
11
Association between early ERCP and mortality in patients with acute cholangitis. ( 28433613 )
2018
12
Platelet hyperaggregability is associated with decreased ADAMTS13 activity and enhanced endotoxemia in patients with acute cholangitis. ( 28628948 )
2018
13
Temporal trends in utilization and outcomes of endoscopic retrograde cholangiopancreatography in acute cholangitis due to choledocholithiasis from 1998 to 2012. ( 28917018 )
2018
14
Tokyo Guidelines 2018: initial management of acute biliary infection and flowchart for acute cholangitis. ( 28941329 )
2018
15
Tokyo Guidelines 2018: diagnostic criteria and severity grading of acute cholangitis (with videos). ( 29032610 )
2018
16
Tokyo Guidelines 2018: antimicrobial therapy for acute cholangitis and cholecystitis. ( 29090866 )
2018
17
Tokyo Guidelines 2018: management bundles for acute cholangitis and cholecystitis. ( 29090868 )
2018
18
Tokyo Guidelines 2018: updated Tokyo Guidelines for the management of acute cholangitis/acute cholecystitis. ( 29334699 )
2018
19
Endoscopic diagnosis and treatment of biliary obstruction due to acute cholangitis and acute pancreatitis secondary to Fasciola hepatica infection. ( 29350372 )
2018
20
Outcomes Associated With Timing of ERCP in Acute Cholangitis Secondary to Choledocholithiasis. ( 29356786 )
2018
21
Clinical applicability of Tokyo guidelines 2018/2013 in diagnosis and severity evaluation of acute cholangitis and determination of a new severity model. ( 29374984 )
2018
22
Re: Acute cholangitis: current concepts. ( 29392900 )
2018
23
Procalcitonin as a Decision-Supporting Marker of Urgent Biliary Decompression in Acute Cholangitis. ( 29480416 )
2018
24
Acute cholangitis - an update. ( 29487761 )
2018
25
Worsening of Acute Cholangitis Caused by a Bile Duct Stone After Hospitalization: A Case Series. ( 29511408 )
2018
26
Gastrointestinal: Unusual cause of acute cholangitis in a chronic pancreatitis patient. ( 29607537 )
2018
27
Early biliary drainage is associated with favourable outcomes in critically-ill patients with acute cholangitis. ( 29657606 )
2018
28
No Association of Timing of Endoscopic Biliary Drainage with Clinical Outcomes in Patients with Non-severe Acute Cholangitis. ( 29663264 )
2018
29
Clinical Impact of Recombinant Soluble Thrombomodulin for Disseminated Intravascular Coagulation Associated with Severe Acute Cholangitis. ( 29699063 )
2018
30
Percutaneous cholecystostomy for high-risk patients with acute cholangitis. ( 29742738 )
2018
31
Von Meyenburg Complexes Found Incidentally in a Patient With Acute Cholangitis. ( 29857154 )
2018
32
Re: Tokyo Guidelines 2018: antimicrobial therapy for acute cholangitis and cholecystitis. ( 29878694 )
2018
33
Response to Re: Tokyo Guidelines 2018: antimicrobial therapy for acute cholangitis and cholecystitis. ( 29878697 )
2018
34
Acute cholangitis complicating a chronic alveolar echinococcosis: an unusual therapeutic cholangioscopy. ( 29895060 )
2018
35
Diagnostic inflammatory markers in acute cholangitis. ( 29907228 )
2018
36
Successful emergency endoscopic drainage for afferent limb syndrome-induced severe acute cholangitis in a patient with altered Roux-en Y anatomy. ( 30039511 )
2018
37
Efficacy and Safety of Single-Session Endoscopic Stone Removal for Acute Cholangitis Associated with Choledocholithiasis. ( 30175087 )
2018
38
Management of liver hydatid cyst with cystobiliary communication and acute cholangitis: a 27-year experience. ( 30191292 )
2018
39
Endoscopic ultrasound-guided choledochoduodenostomy using a lumen apposing metal stent for acute cholangitis. ( 30249569 )
2018
40
Diagnostic value of elevated serum carbohydrate antigen 199 level in acute cholangitis secondary to choledocholithiasis. ( 30294608 )
2018
41
A duplicated Gallbladder in a Patient Presenting with Acute Cholangitis. A Case Study and a Literature Review. ( 30596619 )
2018
42
Bacteremia Due to Arthrobacter creatinolyticus in an Elderly Diabetic Man with Acute Cholangitis. ( 27357988 )
2017
43
Usefulness of the Delta Neutrophil Index as a Promising Prognostic Marker of Acute Cholangitis in Emergency Departments. ( 27559701 )
2017
44
Procalcitonin is a useful biomarker to predict severe acute cholangitis: a single-center prospective study. ( 27783206 )
2017
45
Optimal Timing of Endoscopic Retrograde Cholangiopancreatography in Acute Cholangitis. ( 27875357 )
2017
46
IL-7 and procalcitonin are useful biomarkers in the comprehensive evaluation of the severity of acute cholangitis. ( 28002647 )
2017
47
Short-course antimicrobial treatment for acute cholangitis with Gram-negative bacillary bacteremia. ( 28027992 )
2017
48
Risk Factors for Multi-Drug Resistant Pathogens and Failure of Empiric First-Line Therapy in Acute Cholangitis. ( 28076388 )
2017
49
The First Case Report of Acute Cholangitis and Bacteremia Due to Neisseria subflava. ( 28090057 )
2017
50
Correction: Risk Factors for Multi-Drug Resistant Pathogens and Failure of Empiric First-Line Therapy in Acute Cholangitis. ( 28192501 )
2017

Variations for Acute Cholangitis

Expression for Acute Cholangitis

Search GEO for disease gene expression data for Acute Cholangitis.

Pathways for Acute Cholangitis

GO Terms for Acute Cholangitis

Cellular components related to Acute Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 CALCA CRP IL1RN IL6 TREM1
2 extracellular space GO:0005615 9.02 CALCA CRP IL1RN IL6 THBD

Biological processes related to Acute Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.65 CALCA IL1RN IL6
2 response to glucocorticoid GO:0051384 9.46 IL1RN IL6
3 positive regulation of interleukin-6 production GO:0032755 9.43 IL1RN IL6
4 humoral immune response GO:0006959 9.4 IL6 TREM1
5 monocyte chemotaxis GO:0002548 9.37 CALCA IL6
6 acute-phase response GO:0006953 9.32 CRP IL6
7 negative regulation of bone resorption GO:0045779 9.26 CALCA IL6
8 negative regulation of lipid storage GO:0010888 9.16 CRP IL6
9 inflammatory response GO:0006954 9.13 CRP IL1RN IL6
10 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 8.62 IL1RN IL6

Sources for Acute Cholangitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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