MCID: ACT036
MIFTS: 35

Acute Cholangitis

Categories: Gastrointestinal diseases, Immune diseases

Aliases & Classifications for Acute Cholangitis

MalaCards integrated aliases for Acute Cholangitis:

Name: Acute Cholangitis 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:14271
NCIt 50 C35334
SNOMED-CT 67 6215006
UMLS 71 C0267917

Summaries for Acute Cholangitis

MalaCards based summary : Acute Cholangitis is related to ascending cholangitis and cholangitis. An important gene associated with Acute Cholangitis is TREM1 (Triggering Receptor Expressed On Myeloid Cells 1), and among its related pathways/superpathways are Folate Metabolism and Cell surface interactions at the vascular wall. The drugs Antitubercular Agents and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include pancreas, kidney and thymus.

Related Diseases for Acute Cholangitis

Diseases in the Cholangitis family:

Autoimmune Cholangitis Acute Cholangitis
Chronic Cholangitis

Diseases related to Acute Cholangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 559)
# Related Disease Score Top Affiliating Genes
1 ascending cholangitis 31.4 GPT F2 CRP ALB
2 cholangitis 30.8 IL6 GPT F2 CRP CEACAM5 ALB
3 acute pancreatitis 30.7 IL6 GPT CRP
4 toxic shock syndrome 30.6 TREM1 IL6 IL1RN CRP
5 suppurative cholangitis 30.6 TREM1 GPT CRP
6 afferent loop syndrome 30.4 GPT ALB
7 choledocholithiasis 30.3 GPT F2 CRP CEACAM5 ALB
8 cholelithiasis 30.3 GPT CRP ALB
9 acute kidney failure 30.2 GPT F2 ALB
10 meningitis 30.1 IL6 CRP ALB
11 obstructive jaundice 30.0 IL6 GPT F2 CRP ALB
12 bacterial meningitis 30.0 IL6 CRP ALB
13 septic arthritis 30.0 TREM1 CRP CALCA
14 peritonitis 30.0 IL6 F2 CRP ALB
15 disseminated intravascular coagulation 29.9 THBD IL6 GPT F2 CRP
16 bilirubin metabolic disorder 29.9 GPT F2 CRP ALB
17 klebsiella pneumonia 29.8 IL6 CRP ALB
18 acalculous cholecystitis 29.8 GPT F2 CRP ALB
19 bronchitis 29.8 IL6 CRP ALB
20 peptic ulcer disease 29.7 TREM1 MUC5AC IL1RN
21 biliary atresia 29.7 GPT F2 ALB
22 portal hypertension 29.7 GPT F2 ALB
23 liver cirrhosis 29.7 IL6 GPT F2 CRP ALB
24 ileus 29.7 IL6 F2 CRP CALCA
25 bile duct cysts 29.7 GPT CEACAM5 ALB
26 cholecystitis 29.6 MUC5AC MUC1 GPT F2 CALCA ALB
27 bronchopneumonia 29.6 IL6 GPT CRP ALB
28 sclerosing cholangitis 29.6 IL6 GPT F2 CEACAM5 ALB
29 neuroma 29.6 MUC1 IL6 CALCA
30 kawasaki disease 29.6 IL6 GPT CRP ALB
31 disease by infectious agent 29.5 IL6 IL1RN GPT CRP ALB
32 endocarditis 29.5 IL6 F2 CRP ALB
33 non-alcoholic fatty liver disease 29.4 IL6 GPT CRP ALB
34 gastroenteritis 29.4 IL6 IL1RN CRP CALCA ALB
35 intrahepatic cholangiocarcinoma 29.3 MUC5AC MUC1 ALB
36 gallbladder disease 29.3 GPT CRP CEACAM5 ALB
37 bacterial pneumonia 29.3 IL6 GPT CRP CALCA ALB
38 exanthem 29.2 IL6 GPT F2 CRP ALB
39 biliary tract disease 29.2 IL6 GPT F2 CRP CEACAM5 ALB
40 cholangiocarcinoma 29.1 MUC5AC MUC1 IL6 CEACAM5
41 chronic kidney disease 29.0 THBD IL6 CRP ALB
42 diverticulitis 28.9 MUC5AC IL6 CRP CEACAM5 ALB
43 cholangitis, primary sclerosing 28.8 IL6 GPT F2 CRP CEACAM5 ALB
44 kidney disease 28.7 THBD MUC1 IL6 CRP ALB
45 respiratory failure 28.6 THBD MUC5AC IL6 IL1RN GPT F2
46 thrombocytopenia 28.5 THBD IL6 IL1RN GPT F2 CRP
47 pneumonia 28.4 TREM1 MUC1 IL6 GPT F2 CRP
48 bile duct cancer 28.3 MUC5AC MUC1 IL6 GPT CEACAM5 ALB
49 inflammatory bowel disease 28.1 TREM1 MUC5AC IL6 IL1RN IL1RAPL2 F2
50 gallbladder disease 1 10.4

Graphical network of the top 20 diseases related to Acute Cholangitis:



Diseases related to Acute Cholangitis

Symptoms & Phenotypes for Acute Cholangitis

Drugs & Therapeutics for Acute Cholangitis

Drugs for Acute Cholangitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antitubercular Agents
2 Anti-Infective Agents
3 Antibiotics, Antitubercular
4 Anti-Bacterial Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Near Infrared Fluorescence Cholangiography (NIRF-C) During Cholecystectomy Sub-Study Completed NCT02070627 Phase 1 Indocyanine Green (ICG)
2 The Necessity of Bile Cultures in Patients With Acute Cholangitis Unknown status NCT02601417
3 Long-term Risks After Endoscopic Retrograde Cholangiopancreatography (ERCP) With Sphincterotomy. Completed NCT04735224
4 An Open-labeled, Randomized Controlled Trial Comparing Between Short Duration And Standard Fourteen Days Antibiotic Treatments In Patients With Acute Common Bile Duct Stone Cholangitis After Successful Endoscopic Biliary Drainage Completed NCT03422042
5 Prognostic Factors Associated With Mortality Within 6 Months Among Critically Ill Elderly Patients Admitted to the Intensive Care Unit With Severe Acute Cholangitis Completed NCT03831529
6 Is Short Antibiotherapy Duration After Drainage Suitable for Patients Admitted in Intensive Care Medicine With a Severe Acute Cholangitis? Recruiting NCT04173286
7 A Comparison of Results With Bile and Blood Culture in Patients With Acute Cholangitis According to Severity Terminated NCT02107560

Search NIH Clinical Center for Acute Cholangitis

Genetic Tests for Acute Cholangitis

Anatomical Context for Acute Cholangitis

MalaCards organs/tissues related to Acute Cholangitis:

40
Pancreas, Kidney, Thymus, Myeloid, T Cells, Endothelial, Neutrophil

Publications for Acute Cholangitis

Articles related to Acute Cholangitis:

(show top 50) (show all 1042)
# Title Authors PMID Year
1
Obstructive Jaundice Due to Duodenal Ulcer Induced by Lenvatinib Therapy for Hepatocellular Carcinoma. 61
33028766 2021
2
Acute cholangitis in intensive care units: clinical, biological, microbiological spectrum and risk factors for mortality: a multicenter study. 61
33549136 2021
3
Todani Type II Choledochal Cyst Mimicking a Pancreatic Cyst. 61
33600028 2021
4
Comment on the management of liver hydatid cyst with cystobiliary communication and acute cholangitis: a 27-year experience. 61
33587153 2021
5
Temocillin as an alternative treatment for acute bacterial cholangitis: a retrospective microbiology susceptibility-based study of 140 episodes. 61
33609262 2021
6
Antibiotic selection based on microbiology and resistance profiles of bile from gallbladder of patients with acute cholecystitis. 61
33536564 2021
7
Prevalence, Resistance Rates, and Risk Factors of Pathogens in Routine Bile Cultures Obtained during Endoscopic Retrograde Cholangiography. 61
32521535 2021
8
A case of a smooth transition to subsequent percutaneous transjejunal biliary intervention for hepatolithiasis after biliary reconstruction by adding jejunostomy during an emergency operation for perforation due to balloon-assisted endoscopy. 61
33400187 2021
9
Title: Endoscopic retrograde cholangiopancreatography and carbohydrate antigen 19-9 in the differential diagnosis of biliary strictures. 61
33438433 2021
10
Comparable safety of ERCP in symptomatic and asymptomatic patients with common bile duct stones: a propensity-matched analysis. 61
33295209 2021
11
[Pathogens' distribution and changes of antimicrobial resistance in the bile of acute biliary tract infection patients]. 61
33412630 2021
12
Antibiotic Therapy of 3 Days May Be Sufficient After Biliary Drainage for Acute Cholangitis: A Systematic Review. 61
33462749 2021
13
Urgent and early EUS-guided biliary drainage in patients with acute cholangitis. 61
33463555 2021
14
ERCP is more challenging in cases of acute biliary pancreatitis than in acute cholangitis - Analysis of the Hungarian ERCP registry data. 61
33309622 2021
15
Alternative application of percutaneous cholecystostomy in patients with biliary obstruction. 61
33388808 2021
16
Factors Associated with Mortality in Severe Acute Cholangitis in a Moroccan Intensive Care Unit: A Retrospective Analysis of 140 Cases. 61
33574838 2021
17
Predictive factors for developing acute cholangitis and/or cholecystitis in patients undergoing delayed cholecystectomy: A retrospective study. 61
32709456 2021
18
Trends and risk factors for 30-day readmissions in patients with acute cholangitis: analysis from the national readmission database. 61
31950275 2021
19
Surgical resection for non-Asian intrahepatic lithiasis: The Brazilian experience. 61
33323316 2020
20
Acute Cholangitis Caused by Boryong Strain of Orientia tsutsugamushi. 61
32869554 2020
21
Role of cholangitis in predicting survival in patients with carcinoma of the ampulla of vater. 61
32823087 2020
22
Novel case of percutaneous access of afferent limb of Roux-en-Y hepaticojejunostomy for biliary decompression and jejunoplasty in a patient with primary sclerosing cholangitis. 61
33117467 2020
23
Association of Anti-TNF Therapy With Increased Risk of Acute Cholangitis in Patients With Primary Sclerosing Cholangitis. 61
33300561 2020
24
Risk Factors for Acute Cholangitis Caused by Enterococcus faecalis and Enterococcus faecium. 61
33361547 2020
25
Fecal Microbiota Transplant in a Patient Infected with Multidrug-Resistant Bacteria: A Case Report. 61
33564705 2020
26
First case report of Solobacterium moorei bacteremia due to acute cholangitis in South Korea. 61
32992021 2020
27
The influence of stone size on spontaneous passage of common bile duct stones in patients with acute cholangitis: A retrospective cohort study. 61
33133588 2020
28
Quantitation of plasma and biliary cefpiramide concentrations in human samples using high-performance liquid chromatography. 61
32706918 2020
29
Inside Plastic Stents versus Metal Stents for Treating Unresectable Malignant Perihilar Biliary Obstructions: A Retrospective Comparative Study. 61
32126740 2020
30
Direct visualization of pancreatic intraductal papillary mucinous neoplasms in a patient with acute cholangitis. 61
32872737 2020
31
Cholangiohydatidosis: an uncommon cause of acute cholangitis. 61
33054284 2020
32
Impact of the Sensitivity to Empiric Antibiotics on Clinical Outcomes after Biliary Drainage for Acute Cholangitis. 61
32050314 2020
33
Surgical clip migration following laparoscopic cholecystectomy: A rare cause of acute cholangitis. 61
32983443 2020
34
Microbiological findings in bile cultures of patients with acute cholangitis undergoing endoscopic retrograde cholangiography. 61
33228372 2020
35
Acute cholangitis on a Lemmel syndrome with signs of diverticulitis. 61
33207900 2020
36
Endoscopic ultrasound-guided gallbladder drainage in pancreatic cancer and cholangitis: A case report. 61
33269057 2020
37
Trend and Predictors of the Utilization of Endoscopic Retrograde Cholangiopancreatography in Acute Pancreatitis Hospitalizations. 61
33312816 2020
38
A rare case of duodenal diaphragm in an adult during ERCP treatment for choledocholithiasis. 61
33160346 2020
39
What is the Treatment Role of Transpapillary Cholecystostomy for Delayed Cholecystectomy in the Coexistence of Acute Cholecystitis and Cholangitis. 61
33048896 2020
40
ERCP for severe acute cholangitis: critical timing. 61
32964847 2020
41
Endoscopic management of non-anastomotic biliary strictures following liver transplantation: Long-term results from a single-center experience. 61
33080081 2020
42
Application and Value of Endoscopic Ultrasonography Guided Biliary Interventional Therapy in Patients With Biliary Obstruction and Surgically Altered Anatomy. 61
32487860 2020
43
National trends and outcomes in timing of ERCP in patients with cholangitis. 61
32611515 2020
44
Clinical characteristics, aetiology and mortality/recurrence risk factors of acute cholangitis in patients with and without biliary stent. 61
32980185 2020
45
Long-Term Safety of Endoscopic Biliary Stents for Cholangitis Complicating Choledocholithiasis: A Multi-Center Study. 61
32932631 2020
46
The efficacy and safety of one-stage endoscopic treatment for ascending acute cholangitis caused by choledocholithiasis with severe comorbidities. 61
31586253 2020
47
Recombinant Human Soluble Thrombomodulin Contributes to a Reduction In-Hospital Mortality of Acute Cholangitis with Disseminated Intravascular Coagulation: A Propensity Score Analyses of a Japanese Nationwide Database. 61
32879147 2020
48
Diagnostic value of hematological parameters in acute pancreatitis. 61
32787347 2020
49
Prognostic factors associated with six month mortality of critically ill elderly patients admitted to the intensive care unit with severe acute cholangitis. 61
32839088 2020
50
Signet-ring cell carcinoma of the ampulla of Vater: a case diagnosed via repeated biopsies. 61
31981088 2020

Variations for Acute Cholangitis

Expression for Acute Cholangitis

Search GEO for disease gene expression data for Acute Cholangitis.

Pathways for Acute Cholangitis

Pathways related to Acute Cholangitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.59 IL6 F2 CRP ALB
2
Show member pathways
11.17 TREM1 THBD F2 CEACAM5
3 10.43 IL6 CRP

GO Terms for Acute Cholangitis

Cellular components related to Acute Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.8 MUC5AC MUC1 IL1RN GPT F2 CEACAM5
2 extracellular region GO:0005576 9.65 TREM1 MUC5AC MUC1 IL6 IL1RN F2
3 Golgi lumen GO:0005796 9.33 MUC5AC MUC1 F2
4 extracellular space GO:0005615 9.32 THBD MUC5AC MUC1 IL6 IL1RN GPT

Biological processes related to Acute Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.78 IL6 IL1RN CRP CALCA
2 cytokine-mediated signaling pathway GO:0019221 9.71 MUC1 IL6 IL1RN IL1RAPL2
3 negative regulation of bone resorption GO:0045779 9.46 IL6 CALCA
4 cellular protein metabolic process GO:0044267 9.46 IL6 F2 CALCA ALB
5 negative regulation of fibrinolysis GO:0051918 9.43 THBD F2
6 negative regulation of lipid storage GO:0010888 9.37 IL6 CRP
7 negative regulation of platelet activation GO:0010544 9.32 THBD F2
8 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.26 IL6 IL1RN
9 leukocyte migration GO:0050900 9.26 TREM1 THBD F2 CEACAM5
10 acute-phase response GO:0006953 8.92 IL6 IL1RN F2 CRP

Sources for Acute Cholangitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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