MCID: ACT036
MIFTS: 37

Acute Cholangitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Acute Cholangitis

MalaCards integrated aliases for Acute Cholangitis:

Name: Acute Cholangitis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:14271
NCIt 50 C35334
SNOMED-CT 68 6215006
UMLS 73 C0267917

Summaries for Acute Cholangitis

MalaCards based summary : Acute Cholangitis is related to cholangitis and melioidosis. An important gene associated with Acute Cholangitis is TREM1 (Triggering Receptor Expressed On Myeloid Cells 1), and among its related pathways/superpathways are Microglia Activation During Neuroinflammation: Microglia Polarization and Lung fibrosis. The drugs Epinephrine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and bone.

Related Diseases for Acute Cholangitis

Diseases in the Cholangitis family:

Acute Cholangitis Chronic Cholangitis

Diseases related to Acute Cholangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 151)
# Related Disease Score Top Affiliating Genes
1 cholangitis 31.6 CRP IL6
2 melioidosis 30.0 IL6 TREM1
3 toxic shock syndrome 29.9 IL6 TREM1
4 obstructive jaundice 29.9 CRP IL6
5 acute cystitis 29.7 CRP IL6
6 bacterial meningitis 29.6 CRP IL6
7 ascending cholangitis 11.1
8 cholecystitis 10.4
9 choledocholithiasis 10.3
10 pancreatitis 10.2
11 crimean-congo hemorrhagic fever 10.2 IL6 TREM1
12 bullous impetigo 10.2 CALCA IL6
13 impetigo 10.2 CALCA IL6
14 diabetic foot ulcers 10.2 CALCA IL6
15 nodular goiter 10.1 CALCA IL6
16 juvenile ankylosing spondylitis 10.1 IL1RN IL6
17 complex regional pain syndrome 10.1 CALCA IL6
18 osteosclerotic myeloma 10.1 IL1RN IL6
19 necrotizing fasciitis 10.1 IL1RN IL6
20 joint disorders 10.1 IL1RN IL6
21 bone resorption disease 10.1 CALCA IL6
22 amyloid tumor 10.1 CALCA IL1RN
23 dengue shock syndrome 10.1 IL1RN IL6
24 aphthous stomatitis 10.1 IL1RN IL6
25 idiopathic neutropenia 10.1 IL1RN IL6
26 cold agglutinin disease 10.1 CRP IL6
27 root resorption 10.1 CALCA IL1RN
28 uremic pruritus 10.1 CRP IL6
29 neutrophilia, hereditary 10.1 CRP IL6
30 spinal disease 10.1 CRP IL6
31 viral pneumonia 10.1 CRP IL6
32 multicentric castleman disease 10.1 CRP IL6
33 castleman disease 10.1 CRP IL6
34 central nervous system vasculitis 10.1 CRP IL6
35 subacute thyroiditis 10.1 CRP IL6
36 intussusception 10.1 CRP IL6
37 louse-borne relapsing fever 10.1 CRP IL6
38 cecal disease 10.1 CRP IL6
39 pyelitis 10.1 CRP IL6
40 suppurative cholangitis 10.1 CRP TREM1
41 ischemic heart disease 10.1 CRP IL6
42 mesenteric lymphadenitis 10.1 CRP IL6
43 viral meningitis 10.1 CRP IL6
44 mycoplasma pneumoniae pneumonia 10.1 CRP IL6
45 sepsis in premature infants 10.1 CALCA CRP
46 hypersensitivity reaction type iii disease 10.1 CRP IL6
47 intermittent explosive disorder 10.1 CRP IL6
48 intermediate coronary syndrome 10.1 CRP IL6
49 systolic heart failure 10.1 CRP IL6
50 prediabetes syndrome 10.1 CRP IL6

Graphical network of the top 20 diseases related to Acute Cholangitis:



Diseases related to Acute Cholangitis

Symptoms & Phenotypes for Acute Cholangitis

Drugs & Therapeutics for Acute Cholangitis

Drugs for Acute Cholangitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
2
Racepinephrine Approved Phase 4 329-65-7 838
3 Peripheral Nervous System Agents Phase 4
4 Adrenergic beta-Agonists Phase 4
5 Anti-Asthmatic Agents Phase 4
6 Bronchodilator Agents Phase 4
7 Mydriatics Phase 4
8 Adrenergic alpha-Agonists Phase 4
9 Sympathomimetics Phase 4
10 Neurotransmitter Agents Phase 4
11 Epinephryl borate Phase 4
12 Autonomic Agents Phase 4
13 Respiratory System Agents Phase 4
14 Adrenergic Agents Phase 4
15 Adrenergic Agonists Phase 4
16 Vasoconstrictor Agents Phase 4
17
Pentoxifylline Approved, Investigational Early Phase 1 6493-05-6 4740
18
Somatostatin Approved, Investigational Not Applicable 51110-01-1, 38916-34-6 53481605
19
Meperidine Approved Not Applicable 57-42-1 4058
20
Midazolam Approved, Illicit Not Applicable 59467-70-8 4192
21
Vitamin A Approved, Nutraceutical, Vet_approved Not Applicable 11103-57-4, 68-26-8 445354
22 Radiation-Protective Agents Early Phase 1
23 Phosphodiesterase Inhibitors Early Phase 1
24 Protective Agents Early Phase 1
25 Antioxidants Early Phase 1
26 Free Radical Scavengers Early Phase 1
27 Platelet Aggregation Inhibitors Early Phase 1
28 Vasodilator Agents Early Phase 1
29 Hormone Antagonists Not Applicable
30 Hormones Not Applicable
31 Anti-Inflammatory Agents Not Applicable
32 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
33 Anti-Infective Agents Not Applicable
34 Antibiotics, Antitubercular Not Applicable
35 Anti-Bacterial Agents Not Applicable
36 Antitubercular Agents Not Applicable
37 Scopolamine hydrobromide Not Applicable 114-49-8
38 Butylscopolammonium Bromide Not Applicable
39 Retinol palmitate Not Applicable
40 retinol Not Applicable

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 Epinephrine Sprayed on the Papilla for the Prevention of Post-ERCP Pancreatitis Unknown status NCT02839356 Phase 4 epinephrine;normal saline
2 Balloon Catheter vs. Basket Catheter for Endoscopic Bile Duct Stone Extraction Completed NCT02909595 Phase 4
3 Near Infrared Fluorescence Cholangiography (NIRF-C) During Cholecystectomy -- Use in Acute Cholecystitis Sub-Study Completed NCT02070627 Phase 1 Indocyanine Green (ICG)
4 Pentoxifylline for the Prevention of PEP Unknown status NCT02992678 Early Phase 1 Pentoxifylline;Placebo
5 Transient ECG Changes in Patients With Acute Biliary Disease Unknown status NCT01706068
6 The Prophylactic Effect of Stilamin on Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis Unknown status NCT01431781 Not Applicable Stilamin+common daily treatment
7 ENBD After Endoscopic Sphincterotomy Plus Large-balloon Dilation for Preventing PEP Unknown status NCT02830984 Not Applicable
8 The Effect of Different Duration of Bolloon Dilation During ESBD Unknown status NCT02958618 Not Applicable
9 Best Biliary Drainage Option in Advanced Klatskin Tumor Completed NCT03104582 Not Applicable
10 Cytological Evaluation of Biliary Epithelium After Endoscopic Sphincterotomy Completed NCT01135732
11 Endoscopic Treatment of Benign Biliary Strictures and Cystic Duct Leakages With a Novel Biodegradable Biliary Stent Completed NCT02353286 Not Applicable
12 Effect of Endoscopic Papillary Balloon Dilation on ERCP Complications Completed NCT02510495 Not Applicable
13 If Different Types of Periampullary Diverticula Affect ERCP Cannulation? Completed NCT03556072
14 The Necessity of Bile Cultures in Patients With Acute Cholangitis Recruiting NCT02601417 Not Applicable
15 Application of Endoscopic Scissors Cutting ENBD Tube in the Treatment of Malignant Hilar Biliary Strictures Recruiting NCT03353181 Not Applicable
16 Effect of 37℃ Non-ionic Contrast Agent During ERCP Procedure in Hilar Cholangiocarcinoma Recruiting NCT03104569 Not Applicable
17 The Comparisons of One-stage and Two-stage Stone Removal in Moderate Cholangitis Recruiting NCT03754491 Not Applicable
18 Short Duration Versus Fourteen Days Antibiotic in Common Bile Duct Cholangitis Recruiting NCT03422042 Not Applicable
19 Effect of Papillary Epinephrine Spraying for the Prevention of Post-ERCP Pancreatitis in Patients Received Octreotide Recruiting NCT03756116 Not Applicable
20 RFA for Malignant Biliary Obstruction Recruiting NCT03166436 Not Applicable
21 Comparison of LCBDE vs ERCP + LC for Choledocholithiasis Recruiting NCT02515474 Not Applicable
22 Long-duration EPBD vs EST for Removal of Biliary Stones Recruiting NCT03683485 Not Applicable
23 Chinese Registry Study on Treatment of Cholecysto-Choledocholithiasis Active, not recruiting NCT02554097
24 Results of Bile and Blood Culture in Patients With Acute Cholangitis Terminated NCT02107560

Search NIH Clinical Center for Acute Cholangitis

Genetic Tests for Acute Cholangitis

Anatomical Context for Acute Cholangitis

MalaCards organs/tissues related to Acute Cholangitis:

41
Liver, Kidney, Bone, Heart, Lymph Node, Pancreas, Thyroid

Publications for Acute Cholangitis

Articles related to Acute Cholangitis:

(show top 50) (show all 299)
# Title Authors Year
1
Saccharomyces cerevisiae fungemia in a critically ill patient with acute cholangitis and long term probiotic use. ( 30505677 )
2019
2
Response to Re: Tokyo Guidelines 2018: antimicrobial therapy for acute cholangitis and cholecystitis. ( 29878697 )
2018
3
Tokyo Guidelines 2018: management bundles for acute cholangitis and cholecystitis. ( 29090868 )
2018
4
Outcomes Associated With Timing of ERCP in Acute Cholangitis Secondary to Choledocholithiasis. ( 29356786 )
2018
5
Tokyo Guidelines 2018: antimicrobial therapy for acute cholangitis and cholecystitis. ( 29090866 )
2018
6
Re: Acute cholangitis: current concepts. ( 29392900 )
2018
7
Clinical applicability of Tokyo guidelines 2018/2013 in diagnosis and severity evaluation of acute cholangitis and determination of a new severity model. ( 29374984 )
2018
8
Endoscopic diagnosis and treatment of biliary obstruction due to acute cholangitis and acute pancreatitis secondary to Fasciola hepatica infection. ( 29350372 )
2018
9
Percutaneous cholecystostomy for high-risk patients with acute cholangitis. ( 29742738 )
2018
10
Tokyo Guidelines 2018: updated Tokyo Guidelines for the management of acute cholangitis/acute cholecystitis. ( 29334699 )
2018
11
Von Meyenburg Complexes Found Incidentally in a Patient with Acute Cholangitis. ( 29857154 )
2018
12
Acute cholangitis - an update. ( 29487761 )
2018
13
Acute cholangitis complicating a chronic alveolar echinococcosis: an unusual therapeutic cholangioscopy. ( 29895060 )
2018
14
Clinical Impact of Recombinant Soluble Thrombomodulin for Disseminated Intravascular Coagulation Associated with Severe Acute Cholangitis. ( 29699063 )
2018
15
Gastrointestinal: Unusual cause of acute cholangitis in a chronic pancreatitis patient. ( 29607537 )
2018
16
Diagnostic inflammatory markers in acute cholangitis. ( 29907228 )
2018
17
No Association of Timing of Endoscopic Biliary Drainage with Clinical Outcomes in Patients with Non-severe Acute Cholangitis. ( 29663264 )
2018
18
Procalcitonin as a Decision-Supporting Marker of Urgent Biliary Decompression in Acute Cholangitis. ( 29480416 )
2018
19
Worsening of Acute Cholangitis Caused by a Bile Duct Stone After Hospitalization: A Case Series. ( 29511408 )
2018
20
Tokyo Guidelines 2018: diagnostic criteria and severity grading of acute cholangitis (with videos). ( 29032610 )
2018
21
Early biliary drainage is associated with favourable outcomes in critically-ill patients with acute cholangitis. ( 29657606 )
2018
22
Re: Tokyo Guidelines 2018: antimicrobial therapy for acute cholangitis and cholecystitis. ( 29878694 )
2018
23
Successful emergency endoscopic drainage for afferent limb syndrome-induced severe acute cholangitis in a patient with altered Roux-en Y anatomy. ( 30039511 )
2018
24
Efficacy and Safety of Single-Session Endoscopic Stone Removal for Acute Cholangitis Associated with Choledocholithiasis. ( 30175087 )
2018
25
Acute cholangitis secondary to hydatid membranes in the biliary tract. ( 30176226 )
2018
26
Management of liver hydatid cyst with cystobiliary communication and acute cholangitis: a 27-year experience. ( 30191292 )
2018
27
Endoscopic ultrasound-guided choledochoduodenostomy using a lumen apposing metal stent for acute cholangitis. ( 30249569 )
2018
28
Endoscopic Retrograde Cholangio-Pancreatography-Obtained Bile Culture Can Guide Antibiotic Therapy in Acute Cholangitis. ( 30282078 )
2018
29
Diagnostic value of elevated serum carbohydrate antigen 199 level in acute cholangitis secondary to choledocholithiasis. ( 30294608 )
2018
30
Short-Course Antibiotic Treatment Is Not Inferior to a Long-Course One in Acute Cholangitis: A Systematic Review. ( 30368681 )
2018
31
Acute Cholangitis with Atypical Clinical Presentation and Imaging. ( 30392151 )
2018
32
Efficacy of Combined Thrombomodulin and Antithrombin in Anticoagulant Therapy for Acute Cholangitis-induced Disseminated Intravascular Coagulation. ( 30449812 )
2018
33
Can endoscopic stone retraction be carried out even in cases with severe acute cholangitis? ( 28425647 )
2017
34
Cholangiohydatidosis: an Infrequent Cause of Obstructive Jaundice and Acute Cholangitis. ( 28425414 )
2017
35
Tokyo Guidelines 2018: initial management of acute biliary infection and flowchart for acute cholangitis. ( 28941329 )
2017
36
Acute Cholangitis After Bilioenteric Anastomosis for Bile Duct Injuries. ( 28744740 )
2017
37
Endoscopic Retrograde Cholangiopancreatography (ERCP) and Acute Cholangitis: The Sooner, the Better. ( 28697150 )
2017
38
Feasibility of initial endoscopic common bile duct stone removal in patients with acute cholangitis. ( 28798923 )
2017
39
Endoscopic management of acute cholangitis according to the TG13. ( 28425666 )
2017
40
Platelet hyperaggregability is associated with decreased ADAMTS13 activity and enhanced endotoxemia in patients with acute cholangitis. ( 28628948 )
2017
41
Is addition of endoscopic sphincterotomy before endoscopic biliary drainage necessary for acute cholangitis as a result of common bile duct stones? ( 28425654 )
2017
42
The First Case Report of Acute Cholangitis and Bacteremia Due to Neisseria subflava. ( 28090057 )
2017
43
Clinical application and verification of the TG13 diagnostic and severity grading criteria for acute cholangitis: an international multicenter observational study. ( 28419764 )
2017
44
Association between early ERCP and mortality in patients with acute cholangitis. ( 28433613 )
2017
45
Temporal trends in utilization and outcomes of endoscopic retrograde cholangiopancreatography in acute cholangitis due to choledocholithiasis from 1998 to 2012. ( 28917018 )
2017
46
Indications and techniques of biliary drainage for acute cholangitis in updated Tokyo guidelines 2018. ( 28834389 )
2017
47
Management of acute cholangitis as a result of occlusion from a self-expandable metallic stent in patients with malignant distal and hilar biliary obstructions. ( 28425663 )
2017
48
Acquired Leukocyte Inclusion Bodies Resembling DAPhle Bodies During Acute Cholangitis. ( 28747290 )
2017
49
A case report of patient with severe acute cholangitis with tigecycline treatment causing coagulopathy and hypofibrinogenemia. ( 29245350 )
2017
50
Endoscopic management of acute cholangitis as a result of common bile duct stones. ( 28425658 )
2017

Variations for Acute Cholangitis

Expression for Acute Cholangitis

Search GEO for disease gene expression data for Acute Cholangitis.

Pathways for Acute Cholangitis

Pathways related to Acute Cholangitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.17 IL1RN IL6
2 11.06 CALCA IL6
3 10.85 IL1RN IL6
4 10.61 CALCA IL6
5 9.9 CRP IL6

GO Terms for Acute Cholangitis

Cellular components related to Acute Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 CALCA CRP IL1RN IL6 TREM1

Biological processes related to Acute Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.65 CALCA IL1RN IL6
2 response to glucocorticoid GO:0051384 9.46 IL1RN IL6
3 positive regulation of interleukin-6 production GO:0032755 9.43 IL1RN IL6
4 humoral immune response GO:0006959 9.4 IL6 TREM1
5 monocyte chemotaxis GO:0002548 9.37 CALCA IL6
6 acute-phase response GO:0006953 9.32 CRP IL6
7 negative regulation of bone resorption GO:0045779 9.26 CALCA IL6
8 inflammatory response GO:0006954 9.26 CALCA CRP IL1RN IL6
9 negative regulation of lipid storage GO:0010888 9.16 CRP IL6
10 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 8.62 IL1RN IL6

Sources for Acute Cholangitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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