MCID: ACT036
MIFTS: 36

Acute Cholangitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Acute Cholangitis

MalaCards integrated aliases for Acute Cholangitis:

Name: Acute Cholangitis 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:14271
NCIt 49 C35334
SNOMED-CT 67 6215006
UMLS 71 C0267917

Summaries for Acute Cholangitis

MalaCards based summary : Acute Cholangitis is related to ascending cholangitis and toxic shock syndrome. An important gene associated with Acute Cholangitis is TREM1 (Triggering Receptor Expressed On Myeloid Cells 1), and among its related pathways/superpathways are Folate Metabolism and Overview of nanoparticle effects. The drugs Anti-Bacterial Agents and Antibiotics, Antitubercular have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and lung.

Related Diseases for Acute Cholangitis

Diseases in the Cholangitis family:

Acute Cholangitis Chronic Cholangitis

Diseases related to Acute Cholangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 488)
# Related Disease Score Top Affiliating Genes
1 ascending cholangitis 31.5 GPT GGTLC3 F2 CRP ALB
2 toxic shock syndrome 30.6 TREM1 IL6 IL1RN CRP
3 cholecystitis 30.5 MUC5AC GPT F2 ALB
4 disseminated intravascular coagulation 30.3 IL6 GPT F2 CRP
5 acute kidney failure 30.2 GPT F2 ALB
6 pancreatitis 30.2 IL6 GGT1 CRP ALB
7 acute pancreatitis 30.1 IL6 IL1RN GPT CRP ALB
8 bacterial meningitis 30.0 IL6 CRP ALB
9 fascioliasis 29.9 GPT GGT1 ALB
10 fatty liver disease, nonalcoholic 1 29.9 GPT GGT1
11 peritonitis 29.9 IL6 F2 CRP ALB
12 cholelithiasis 29.8 GPT GGT1 CRP ALB
13 meningitis 29.8 IL6 CRP CALCA ALB
14 cholestasis 29.8 IL6 GPT GGT1 F2 ALB
15 septic arthritis 29.8 TREM1 IL6 CRP CALCA
16 liver cirrhosis 29.7 GPT GGT1 F2 ALB
17 cholangitis 29.7 IL6 GPT GGT1 F2 CRP CEACAM5
18 ileus 29.7 IL6 F2 CRP CALCA
19 acalculous cholecystitis 29.7 GPT F2 CRP ALB
20 portal hypertension 29.7 GPT F2 ALB
21 urinary tract obstruction 29.6 GGT1 CRP ALB
22 bronchitis 29.6 IL6 CRP CALCA ALB
23 bronchopneumonia 29.6 IL6 GPT CRP ALB
24 kawasaki disease 29.5 IL6 GPT CRP ALB
25 endocarditis 29.5 IL6 F2 CRP ALB
26 diarrhea 29.5 IL6 GPT CALCA ALB
27 obstructive jaundice 29.5 IL6 GPT GGT1 F2 CRP ALB
28 peptic ulcer disease 29.4 TREM1 MUC5AC IL1RN ALB
29 suppurative cholangitis 29.3 TREM1 GPT GGTLC3 GGT2 GGT1
30 biliary atresia 29.3 GPT GGT1 F2 ALB
31 gastroenteritis 29.3 IL6 IL1RN CRP CALCA ALB
32 bacterial pneumonia 29.3 IL6 GPT CRP CALCA ALB
33 acute cystitis 29.1 IL6 GPT F2 CRP ALB
34 fatty liver disease 29.0 IL6 GPT GGT1 CRP ALB
35 liver disease 29.0 IL6 GPT GGT1 F2 ALB
36 cholangiocarcinoma 28.9 MUC5AC IL6 GGT1 CEACAM5
37 respiratory failure 28.7 MUC5AC IL6 IL1RN GPT F2 CRP
38 sclerosing cholangitis 28.5 IL6 GPT GGT1 F2 CEACAM5 ALB
39 bile duct cancer 28.4 MUC5AC IL6 GPT CEACAM5 ALB
40 thrombocytopenia 28.3 IL6 IL1RN GPT GGT1 F2 CRP
41 bilirubin metabolic disorder 28.1 GPT GGTLC3 GGT2 GGT1 F2 CRP
42 bile duct cysts 28.0 GPT GGTLC3 GGT2 GGT1 CEACAM5
43 choledocholithiasis 27.9 GPT GGTLC3 GGT2 GGT1 F2 CRP
44 gallbladder disease 27.1 GPT GGTLC3 GGT2 GGT1 CRP CEACAM5
45 biliary tract disease 26.8 IL6 GPT GGTLC3 GGT2 GGT1 F2
46 bullous impetigo 10.5 IL6 CALCA
47 sepsis in premature infants 10.5 CRP CALCA
48 systemic onset juvenile idiopathic arthritis 10.5 IL1RN IL1RAPL2
49 indolent myeloma 10.4 IL6 IL1RN
50 cold agglutinin disease 10.4 IL6 CRP

Graphical network of the top 20 diseases related to Acute Cholangitis:



Diseases related to Acute Cholangitis

Symptoms & Phenotypes for Acute Cholangitis

Drugs & Therapeutics for Acute Cholangitis

Drugs for Acute Cholangitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Bacterial Agents Phase 4
2 Antibiotics, Antitubercular Phase 4
3
Sage Approved
4
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
5
Lidocaine Approved, Vet_approved 137-58-6 3676
6
Sodium citrate Approved, Investigational 68-04-2
7
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
8
Rocuronium Approved 119302-91-9, 143558-00-3 441290
9
Sevoflurane Approved, Vet_approved 28523-86-6 5206
10
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
11
Indomethacin Approved, Investigational 53-86-1 3715
12
Citric acid Approved, Nutraceutical, Vet_approved 77-92-9 311
13 Antitubercular Agents
14 Tea
15 Citrate
16 Anesthetics
17 Hemostatics
18 Coagulants
19 Anti-Infective Agents

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Albumin Administration in the Prevention of Hepatorenal Syndrome and Death in Patients With Cirrhosis, Bacterial Infections Other Than Spontaneous Bacterial Peritonitis and High Risk of Hospital Mortality Terminated NCT02034279 Phase 4 Albumin
2 Near Infrared Fluorescence Cholangiography (NIRF-C) During Cholecystectomy Sub-Study Completed NCT02070627 Phase 1 Indocyanine Green (ICG)
3 The Necessity of Bile Cultures in Patients With Acute Cholangitis Unknown status NCT02601417
4 The Assessment of Awareness and Implementation of the SAGES Safe Cholecystectomy Program Among Polish Surgeons, as Well as Their Opinion on the Usefulness of the SAGES Safe Cholecystectomy Rules: Increasing the Safety of Cholecystectomy by Popularising the SAGES Safe Cholecystectomy Program Unknown status NCT03155321
5 Prospective Randomized Study Comparing the Effects of Endoscopic Sphincterotomy (EST) and Endoscopic Papillary Balloon Dilation (EPBD) in Patients With Acute Biliary Pancreatitis (ABP) Unknown status NCT02668081
6 Radiofrequency Ablation Plus Stenting Versus Stenting Alone for Treatment of Malignant Biliary Obstruction Unknown status NCT03166436
7 Prognostic Factors Associated With Mortality Within 6 Months Among Critically Ill Elderly Patients Admitted to the Intensive Care Unit With Severe Acute Cholangitis Completed NCT03831529
8 An Open-labeled, Randomized Controlled Trial Comparing Between Short Duration And Standard Fourteen Days Antibiotic Treatments In Patients With Acute Common Bile Duct Stone Cholangitis After Successful Endoscopic Biliary Drainage Completed NCT03422042
9 Cytological Evaluation of Biliary Epithelium After Previous Endoscopic Sphincterotomy for Benign Disease Completed NCT01135732
10 A Randomized Trial to Identify the Optimal Approach for Management of Difficult Bile Duct Stones Completed NCT00852072
11 A Prospective Randomized Trial Comparing EUS Guided ERCP Without Fluoroscopy With Standard ERCP in Common Bile Duct Stone Removal Completed NCT02870686
12 Comparison of Bi-spectral Index-Controlled Sedation During a Thoracic Epidural Anesthesia With General Anesthesia in Laparoscopic Cholecystectomy Completed NCT03107832
13 Common Bile Duct Stone Management: What Have we Learned? Completed NCT02155244
14 Laparoscopic Cholecystectomy is no More Risky in Emergent Cases With in Cardiopulmonary Risk: Fundus-Callot Cholecystectomy With Low Pressure Pneumo-peritoneum VS Open Cholecystectomy - Randomized Controlled Trials Completed NCT04373447
15 Division of Hepato-gastroenterology; Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung,Taiwan Recruiting NCT03754491
16 Is Short Antibiotherapy Duration After Drainage Suitable for Patients Admitted in Intensive Care Medicine With a Severe Acute Cholangitis? Recruiting NCT04173286
17 The Clinical Evaluation of Oddi Spincteroplasty With Blood Vessel Clamp After Iatrogenic Injury by ERCP Recruiting NCT03795584
18 Randomized Multicentre Double-blind Clinical Trial Comparing ERCP vs ERCP and Transmural Gall Bladder Drainage in Non-surgical Patients With Symptomatic Choledocholithiasis Recruiting NCT03921502
19 Endoscopic Sphincterotomy (EST) for Bile Duct Gallstones Cause Damage to the Ampulla of Vater and Sphincter of Oddi (SO): Endoclip Papillaplasty Help Recover the Damaged SO Function and Possibly Prevent Gallstone Recurrence Recruiting NCT04183036
20 Microbial Profile of Cholangitis in Patients Undergoing Biliary Intervention Not yet recruiting NCT04216745
21 A Comparison of Results With Bile and Blood Culture in Patients With Acute Cholangitis According to Severity Terminated NCT02107560

Search NIH Clinical Center for Acute Cholangitis

Genetic Tests for Acute Cholangitis

Anatomical Context for Acute Cholangitis

MalaCards organs/tissues related to Acute Cholangitis:

40
Liver, Pancreas, Lung, T Cells, Thymus, Heart, Colon

Publications for Acute Cholangitis

Articles related to Acute Cholangitis:

(show top 50) (show all 1005)
# Title Authors PMID Year
1
Outcomes following early versus delayed cholecystectomy performed for acute cholangitis. 61
31482348 2020
2
A different kind of acute cholangitis: Subacute Ikeda type II peripapillary choledochoduodenal fistula? 61
32409178 2020
3
A rare case of acute cholangitis after endoscopic ampullectomy. 61
32450700 2020
4
Post-endoscopic retrograde cholangiopancreatography pancreatitis in single-stage endoscopic common bile duct stone removal. 61
32514443 2020
5
Response to: Approach to evaluation of choledocholithiasis in patient with or without acute cholangitis. 61
32125414 2020
6
Application and Value of Endoscopic Ultrasonography Guided Biliary Interventional Therapy in Patients With Biliary Obstruction and Surgically Altered Anatomy. 61
32487860 2020
7
Prevalence, resistance-rates and risk-factors of pathogens in routine bile cultures obtained during endoscopic retrograde cholangiography. 61
32521535 2020
8
Troubleshooting for severe acute cholangitis caused by proximally migrated metal stent into the intrahepatic bile duct: Stent shortening via a balloon catheter. 61
32472625 2020
9
Hepatectomy and intrahepatic hepaticocutaneous jejunostomy for bilateral primary hepatolithiasis: Case report. 61
32512411 2020
10
Three-day antibiotic treatment for acute cholangitis due to choledocholithiasis with successful biliary duct drainage: A single-center retrospective cohort study. 61
32376307 2020
11
Utilization of a new technology of 3D biliary CT for ERCP-related procedures: a case report. 61
32448154 2020
12
[Novel Insights of Primary Sclerosing Cholangitis and Primary Biliary Cholangitis]. 61
32448856 2020
13
Diagnostic inflammatory markers of acute cholangitis in liver transplant recipients. 61
32378775 2020
14
Antimicrobial therapy of 3 days or less is sufficient after successful ERCP for acute cholangitis. 61
32213042 2020
15
ERCP for acute cholangitis: timing is everything. 61
32204811 2020
16
Diagnostic performance of 64-MDCT in detecting ERCP-proven periampullary duodenal diverticula. 61
31893332 2020
17
Early malfunction of a biliary self-expandable metal stent with an antireflux valve: A case report. 61
32311973 2020
18
Management of portal cavernoma-associated cholangiopathy: Single-centre experience. 61
31255533 2020
19
Microbiology and clinical characteristics of acute cholangitis with their impact on mortality; a retrospective cross sectional study. 61
32296203 2020
20
The Impact of Laparoscopic Cholecystectomy on 30-Day Readmission Rate for Acute Cholangitis Patients: A Single-Center Study. 61
32248392 2020
21
Emergent versus urgent ERCP in acute cholangitis: a systematic review and meta-analysis. 61
31628955 2020
22
Rethinking fibrinogen storage disease of the liver: ground glass and globular inclusions do not represent a congenital metabolic disorder but acquired collective retention of proteins. 61
32330484 2020
23
Disparities in bile duct injury care. 61
31190224 2020
24
Risk factors for adverse events associated with bile leak during EUS-guided hepaticogastrostomy. 61
32295968 2020
25
Inside Plastic Stents versus Metal Stents for Treating Unresectable Malignant Perihilar Biliary Obstructions: A Retrospective Comparative Study. 61
32126740 2020
26
Safety and efficacy of emergency laparoscopic common bile duct exploration in elderly patients with complicated acute cholangitis. 61
31209606 2020
27
Timing of Performing Endoscopic Retrograde Cholangiopancreatography and Inpatient Mortality in Acute Cholangitis: A Systematic Review and Meta-Analysis. 61
32352721 2020
28
A novel integrated inside biliary stent and nasobiliary drainage catheter system for biliary drainage (with video). 61
31654477 2020
29
[Gallstone disease - interdisciplinary treatment]. 61
32120403 2020
30
Endoscopic Self-Expandable Metal Stent Placement for Malignant Afferent Loop Obstruction After Pancreaticoduodenectomy: A Case Series and Review. 61
32124582 2020
31
Active bleeding due to a hepatic arterial pseudoaneurysm that occurred after acute cholangitis. 61
32054281 2020
32
Emergent Treatment of Acute Cholangitis and Acute Cholecystitis. 61
32139966 2020
33
Use of microbiological and patient data for choice of empirical antibiotic therapy in acute cholangitis. 61
32164573 2020
34
Impact of the Sensitivity to Empiric Antibiotics on Clinical Outcomes after Biliary Drainage for Acute Cholangitis. 61
32050314 2020
35
Rapid formation of large pseudostones and acute cholangitis caused by ceftriaxone treatment for bacterial pneumonia in a patient on kidney transplantation: potential risk of ceftriaxone use in patients with decreased kidney function. 61
31531767 2020
36
Quantification of metronidazole in human bile fluid and plasma by liquid chromatography-tandem mass spectrometry. 61
31911204 2020
37
Signet-ring cell carcinoma of the ampulla of Vater: a case diagnosed via repeated biopsies. 61
31981088 2020
38
Autologous Adipose Tissue-Derived Mesenchymal Stem Cells Introduced by Biliary Stents or Local Immersion in Porcine Bile Duct Anastomoses. 61
31742878 2020
39
Management of afferent loop syndrome after Roux-en-Y subtotal gastrectomy and choledocolithiasis with recurrent cholangitis. 61
31907217 2020
40
Increasing burden of biliary tract infection caused by extended-spectrum beta-lactamase-producing organisms in Korea: A nationwide population-based study. 61
31359494 2020
41
Shortening antibiotic duration in the treatment of acute cholangitis: rationale and study protocol for an open-label randomized controlled trial. 61
31952554 2020
42
A nomogram for predicting the risk of sepsis in patients with acute cholangitis. 61
31429338 2020
43
Dynamic Monitoring of sTREM-1 and Other Biomarkers in Acute Cholangitis. 61
32508526 2020
44
ERCP for severe acute cholangitis: The earlier, the better. 61
32009619 2020
45
Life-threatening duodenal perforation complicating endoscopic retrograde cholangiopanceatography: A case series. 61
31978721 2020
46
Trends and risk factors for 30-day readmissions in patients with acute cholangitis: analysis from the national readmission database. 61
31950275 2020
47
Clinical Efficacy Analysis of the Combination of the Laparoscope and Preoperative or Intraoperative Duodenoscope in the Treatment of Cholecystolithiasis with Choledocholithiasis: A Retrospective Study. 61
31647359 2019
48
Laparoscopic cholecystectomy after endoscopic treatment of choledocholithiasis: a retrospective comparative study. 61
30644060 2019
49
The risk of acute cholangitis after endoscopic stenting for malignant hilar strictures: A large comprehensive study. 61
31802535 2019
50
Management of liver hydatid cyst with cystobiliary communication and acute cholangitis: a 27-year experience. 61
30191292 2019

Variations for Acute Cholangitis

Expression for Acute Cholangitis

Search GEO for disease gene expression data for Acute Cholangitis.

Pathways for Acute Cholangitis

Pathways related to Acute Cholangitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.43 IL6 GGT2 GGT1 F2 CRP ALB
2 10.23 IL6 CRP

GO Terms for Acute Cholangitis

Cellular components related to Acute Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 TREM1 MUC5AC IL6 IL1RN F2 CRP
2 extracellular exosome GO:0070062 9.61 MUC5AC IL1RN GPT GGTLC3 GGT2 GGT1
3 extracellular space GO:0005615 9.28 MUC5AC IL6 IL1RN GPT GGT1 F2

Biological processes related to Acute Cholangitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.78 IL6 IL1RN CRP CALCA
2 cellular protein metabolic process GO:0044267 9.62 IL6 F2 CALCA ALB
3 zymogen activation GO:0031638 9.49 GGT2 GGT1
4 negative regulation of bone resorption GO:0045779 9.46 IL6 CALCA
5 negative regulation of lipid storage GO:0010888 9.43 IL6 CRP
6 regulation of immune system process GO:0002682 9.4 GGT2 GGT1
7 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.37 IL6 IL1RN
8 acute-phase response GO:0006953 9.33 IL6 F2 CRP
9 peptide modification GO:0031179 9.26 GGT2 GGT1
10 glutathione catabolic process GO:0006751 9.13 GGTLC3 GGT2 GGT1
11 leukotriene D4 biosynthetic process GO:1901750 8.8 GGTLC3 GGT2 GGT1

Molecular functions related to Acute Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidyltransferase activity GO:0000048 8.96 GGT2 GGT1
2 glutathione hydrolase activity GO:0036374 8.8 GGTLC3 GGT2 GGT1

Sources for Acute Cholangitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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