MCID: ACT036
MIFTS: 36

Acute Cholangitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Acute Cholangitis

MalaCards integrated aliases for Acute Cholangitis:

Name: Acute Cholangitis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:14271
NCIt 50 C35334
SNOMED-CT 68 6215006
UMLS 73 C0267917

Summaries for Acute Cholangitis

MalaCards based summary : Acute Cholangitis is related to cholangitis and toxic shock syndrome. An important gene associated with Acute Cholangitis is TREM1 (Triggering Receptor Expressed On Myeloid Cells 1), and among its related pathways/superpathways are IL6-mediated signaling events and Interleukin-10 signaling. The drugs Epinephrine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include liver, neutrophil and lung.

Related Diseases for Acute Cholangitis

Diseases in the Cholangitis family:

Acute Cholangitis Chronic Cholangitis

Diseases related to Acute Cholangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 135)
# Related Disease Score Top Affiliating Genes
1 cholangitis 31.4 CRP IL6
2 toxic shock syndrome 30.2 IL6 TREM1
3 melioidosis 30.2 IL6 TREM1
4 bacterial meningitis 29.8 CRP IL6
5 meningitis 29.2 CRP IL6
6 kawasaki disease 29.1 CRP IL6
7 ascending cholangitis 11.0
8 crimean-congo hemorrhagic fever 10.6 IL6 TREM1
9 osteosclerotic myeloma 10.5 IL1RN IL6
10 necrotizing fasciitis 10.5 IL1RN IL6
11 hydrarthrosis 10.5 IL1RN IL6
12 joint disorders 10.5 IL1RN IL6
13 aphthous stomatitis 10.5 IL1RN IL6
14 dengue shock syndrome 10.5 IL1RN IL6
15 idiopathic neutropenia 10.5 IL1RN IL6
16 cold agglutinin disease 10.5 CRP IL6
17 cardiogenic shock 10.4 CRP IL6
18 neutrophilia, hereditary 10.4 CRP IL6
19 uremic pruritus 10.4 CRP IL6
20 spinal disease 10.4 CRP IL6
21 castleman disease 10.4 CRP IL6
22 angina pectoris 10.4 CRP IL6
23 viral pneumonia 10.4 CRP IL6
24 cecal disease 10.4 CRP IL6
25 central nervous system vasculitis 10.4 CRP IL6
26 subacute thyroiditis 10.4 CRP IL6
27 intussusception 10.4 CRP IL6
28 louse-borne relapsing fever 10.4 CRP IL6
29 multicentric castleman disease 10.4 CRP IL6
30 suppurative cholangitis 10.4 CRP TREM1
31 hypersensitivity reaction type iii disease 10.4 CRP IL6
32 ischemic heart disease 10.4 CRP IL6
33 mesenteric lymphadenitis 10.4 CRP IL6
34 alexithymia 10.4 CRP IL6
35 intermittent explosive disorder 10.4 CRP IL6
36 intermediate coronary syndrome 10.4 CRP IL6
37 acute cystitis 10.4 CRP IL6
38 systolic heart failure 10.4 CRP IL6
39 aggressive periodontitis 10.4 IL1RN IL6
40 polyarteritis nodosa 10.4 CRP IL6
41 prediabetes syndrome 10.4 CRP IL6
42 acute pyelonephritis 10.4 CRP IL6
43 apnea, obstructive sleep 10.4 CRP IL6
44 perinatal necrotizing enterocolitis 10.4 CRP IL6
45 viral meningitis 10.4 CRP IL6
46 hyper-igd syndrome 10.4 CRP IL1RN
47 infective endocarditis 10.4 CRP IL6
48 hemorrhagic fever with renal syndrome 10.4 CRP IL6
49 cartilage disease 10.4 CRP IL1RN
50 lymph node disease 10.4 CRP IL6

Graphical network of the top 20 diseases related to Acute Cholangitis:



Diseases related to Acute Cholangitis

Symptoms & Phenotypes for Acute Cholangitis

Drugs & Therapeutics for Acute Cholangitis

Drugs for Acute Cholangitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
2
Racepinephrine Approved Phase 4 329-65-7 838
3 Adrenergic Agents Phase 4
4 Adrenergic Agonists Phase 4
5 Adrenergic alpha-Agonists Phase 4
6 Adrenergic beta-Agonists Phase 4
7 Anti-Asthmatic Agents Phase 4
8 Autonomic Agents Phase 4
9 Bronchodilator Agents Phase 4
10 Epinephryl borate Phase 4
11 Mydriatics Phase 4
12 Neurotransmitter Agents Phase 4
13 Peripheral Nervous System Agents Phase 4
14 Respiratory System Agents Phase 4
15 Vasoconstrictor Agents Phase 4
16
Somatostatin Approved, Investigational Not Applicable 38916-34-6, 51110-01-1 53481605
17
Menthol Approved Not Applicable 2216-51-5 16666
18
Pentoxifylline Approved, Investigational Early Phase 1 6493-05-6 4740
19
Meperidine Approved Not Applicable 57-42-1 4058
20
Midazolam Approved, Illicit Not Applicable 59467-70-8 4192
21 Anti-Inflammatory Agents Not Applicable
22 Hormone Antagonists Not Applicable
23 Hormones Not Applicable
24 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
25 Anti-Bacterial Agents Not Applicable
26 Antibiotics, Antitubercular Not Applicable
27 Anti-Infective Agents Not Applicable
28 Antitubercular Agents Not Applicable
29 Antioxidants Early Phase 1
30 Phosphodiesterase Inhibitors Early Phase 1
31 Platelet Aggregation Inhibitors Early Phase 1
32 Protective Agents Early Phase 1
33 Radiation-Protective Agents Early Phase 1
34 Vasodilator Agents Early Phase 1
35 Butylscopolammonium Bromide Not Applicable
36 Scopolamine hydrobromide Not Applicable 114-49-8

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Epinephrine Sprayed on the Papilla for the Prevention of Post-ERCP Pancreatitis Unknown status NCT02839356 Phase 4 epinephrine;normal saline
2 Balloon Catheter vs. Basket Catheter for Endoscopic Bile Duct Stone Extraction Completed NCT02909595 Phase 4
3 Near Infrared Fluorescence Cholangiography (NIRF-C) During Cholecystectomy -- Use in Acute Cholecystitis Sub-Study Completed NCT02070627 Phase 1 Indocyanine Green (ICG)
4 Transient ECG Changes in Patients With Acute Biliary Disease Unknown status NCT01706068
5 The Prophylactic Effect of Stilamin on Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis Unknown status NCT01431781 Not Applicable Stilamin+common daily treatment
6 ENBD After Endoscopic Sphincterotomy Plus Large-balloon Dilation for Preventing PEP Unknown status NCT02830984 Not Applicable
7 Best Biliary Drainage Option in Advanced Klatskin Tumor Completed NCT03104582 Not Applicable
8 Cytological Evaluation of Biliary Epithelium After Endoscopic Sphincterotomy Completed NCT01135732
9 Endoscopic Treatment of Benign Biliary Strictures and Cystic Duct Leakages With a Novel Biodegradable Biliary Stent Completed NCT02353286 Not Applicable
10 Effect of Endoscopic Papillary Balloon Dilation on ERCP Complications Completed NCT02510495 Not Applicable
11 The Necessity of Bile Cultures in Patients With Acute Cholangitis Recruiting NCT02601417 Not Applicable
12 Application of Endoscopic Scissors Cutting ENBD Tube in the Treatment of Malignant Hilar Biliary Strictures Recruiting NCT03353181 Not Applicable
13 Effect of 37℃ Non-ionic Contrast Agent During ERCP Procedure in Hilar Cholangiocarcinoma Recruiting NCT03104569 Not Applicable
14 Short Duration Versus Fourteen Days Antibiotic in Common Bile Duct Cholangitis Recruiting NCT03422042 Not Applicable
15 Pentoxifylline for the Prevention of PEP Recruiting NCT02992678 Early Phase 1 Pentoxifylline;Placebo
16 RFA for Malignant Biliary Obstruction Recruiting NCT03166436 Not Applicable
17 If Different Types of Periampullary Diverticula Affect ERCP Cannulation? Recruiting NCT03556072
18 Comparison of LCBDE vs ERCP + LC for Choledocholithiasis Recruiting NCT02515474 Not Applicable
19 Optimization and Cost-effective Analysis of Secondary Biliary Stones' Managements Enrolling by invitation NCT02554097
20 The Effect of Different Duration of Bolloon Dilation During ESBD Not yet recruiting NCT02958618 Not Applicable
21 Results of Bile and Blood Culture in Patients With Acute Cholangitis Terminated NCT02107560

Search NIH Clinical Center for Acute Cholangitis

Genetic Tests for Acute Cholangitis

Anatomical Context for Acute Cholangitis

MalaCards organs/tissues related to Acute Cholangitis:

41
Liver, Neutrophil, Lung, Myeloid

Publications for Acute Cholangitis

Articles related to Acute Cholangitis:

(show top 50) (show all 275)
# Title Authors Year
1
Response to Re: Tokyo Guidelines 2018: antimicrobial therapy for acute cholangitis and cholecystitis. ( 29878697 )
2018
2
Tokyo Guidelines 2018: management bundles for acute cholangitis and cholecystitis. ( 29090868 )
2018
3
Outcomes Associated With Timing of ERCP in Acute Cholangitis Secondary to Choledocholithiasis. ( 29356786 )
2018
4
Tokyo Guidelines 2018: antimicrobial therapy for acute cholangitis and cholecystitis. ( 29090866 )
2018
5
Re: Acute cholangitis: current concepts. ( 29392900 )
2018
6
Clinical applicability of Tokyo guidelines 2018/2013 in diagnosis and severity evaluation of acute cholangitis and determination of a new severity model. ( 29374984 )
2018
7
Endoscopic diagnosis and treatment of biliary obstruction due to acute cholangitis and acute pancreatitis secondary to Fasciola hepatica infection. ( 29350372 )
2018
8
Percutaneous cholecystostomy for high-risk patients with acute cholangitis. ( 29742738 )
2018
9
Tokyo Guidelines 2018: updated Tokyo Guidelines for the management of acute cholangitis/acute cholecystitis. ( 29334699 )
2018
10
Von Meyenburg Complexes Found Incidentally in a Patient with Acute Cholangitis. ( 29857154 )
2018
11
Acute cholangitis - an update. ( 29487761 )
2018
12
Acute cholangitis complicating a chronic alveolar echinococcosis: an unusual therapeutic cholangioscopy. ( 29895060 )
2018
13
Clinical Impact of Recombinant Soluble Thrombomodulin for Disseminated Intravascular Coagulation Associated with Severe Acute Cholangitis. ( 29699063 )
2018
14
Gastrointestinal: Unusual cause of acute cholangitis in a chronic pancreatitis patient. ( 29607537 )
2018
15
Diagnostic inflammatory markers in acute cholangitis. ( 29907228 )
2018
16
No Association of Timing of Endoscopic Biliary Drainage with Clinical Outcomes in Patients with Non-severe Acute Cholangitis. ( 29663264 )
2018
17
Procalcitonin as a Decision-Supporting Marker of Urgent Biliary Decompression in Acute Cholangitis. ( 29480416 )
2018
18
Worsening of Acute Cholangitis Caused by a Bile Duct Stone After Hospitalization: A Case Series. ( 29511408 )
2018
19
Tokyo Guidelines 2018: diagnostic criteria and severity grading of acute cholangitis (with videos). ( 29032610 )
2018
20
Early biliary drainage is associated with favourable outcomes in critically-ill patients with acute cholangitis. ( 29657606 )
2018
21
Re: Tokyo Guidelines 2018: antimicrobial therapy for acute cholangitis and cholecystitis. ( 29878694 )
2018
22
Can endoscopic stone retraction be carried out even in cases with severe acute cholangitis? ( 28425647 )
2017
23
Cholangiohydatidosis: an Infrequent Cause of Obstructive Jaundice and Acute Cholangitis. ( 28425414 )
2017
24
Tokyo Guidelines 2018: initial management of acute biliary infection and flowchart for acute cholangitis. ( 28941329 )
2017
25
Acute Cholangitis After Bilioenteric Anastomosis for Bile Duct Injuries. ( 28744740 )
2017
26
Endoscopic Retrograde Cholangiopancreatography (ERCP) and Acute Cholangitis: The Sooner, the Better. ( 28697150 )
2017
27
Feasibility of initial endoscopic common bile duct stone removal in patients with acute cholangitis. ( 28798923 )
2017
28
Endoscopic management of acute cholangitis according to the TG13. ( 28425666 )
2017
29
Platelet hyperaggregability is associated with decreased ADAMTS13 activity and enhanced endotoxemia in patients with acute cholangitis. ( 28628948 )
2017
30
Is addition of endoscopic sphincterotomy before endoscopic biliary drainage necessary for acute cholangitis as a result of common bile duct stones? ( 28425654 )
2017
31
The First Case Report of Acute Cholangitis and Bacteremia Due to Neisseria subflava. ( 28090057 )
2017
32
Clinical application and verification of the TG13 diagnostic and severity grading criteria for acute cholangitis: an international multicenter observational study. ( 28419764 )
2017
33
Association between early ERCP and mortality in patients with acute cholangitis. ( 28433613 )
2017
34
Temporal trends in utilization and outcomes of endoscopic retrograde cholangiopancreatography in acute cholangitis due to choledocholithiasis from 1998 to 2012. ( 28917018 )
2017
35
Indications and techniques of biliary drainage for acute cholangitis in updated Tokyo guidelines 2018. ( 28834389 )
2017
36
Management of acute cholangitis as a result of occlusion from a self-expandable metallic stent in patients with malignant distal and hilar biliary obstructions. ( 28425663 )
2017
37
Acquired Leukocyte Inclusion Bodies Resembling DAPhle Bodies During Acute Cholangitis. ( 28747290 )
2017
38
A case report of patient with severe acute cholangitis with tigecycline treatment causing coagulopathy and hypofibrinogenemia. ( 29245350 )
2017
39
Endoscopic management of acute cholangitis as a result of common bile duct stones. ( 28425658 )
2017
40
Endoscopic-ultrasonography-guided biliary drainage for repetitive acute cholangitis of the accessory hepatic duct obstructed by clipping during laparoscopic cholecystectomy. ( 28381783 )
2017
41
Current strategies for endoscopic management of acute cholangitis. ( 28425650 )
2017
42
Comparison of acute cholangitis with or without common bile duct dilatation. ( 28587432 )
2017
43
Risk Factors for Multi-Drug Resistant Pathogens and Failure of Empiric First-Line Therapy in Acute Cholangitis. ( 28076388 )
2017
44
Evaluation and Comparison of Charcot's Triad and Tokyo Guidelines for the Diagnosis of Acute Cholangitis. ( 29089703 )
2017
45
Updated comprehensive epidemiology, microbiology, and outcomes among patients with acute cholangitis. ( 28371094 )
2017
46
Case Report: Biliary Pancreatitis With Acute Cholangitis in a Patient Under Anticoagulant Treatment With Dabigatran. ( 29075173 )
2017
47
Acute Cholangitis Management: Prevention of Organ Failure and Death. ( 27556590 )
2016
48
Association of Admission Laboratory Values and the Timing of Endoscopic Retrograde Cholangiopancreatography With Clinical Outcomes in Acute Cholangitis. ( 27557050 )
2016
49
Controversy and progress for treatment of acute cholangitis after Tokyo Guidelines (TG13). ( 26961212 )
2016
50
Optimal Timing of Endoscopic Retrograde Cholangiopancreatography in Acute Cholangitis. ( 27875357 )
2016

Variations for Acute Cholangitis

Expression for Acute Cholangitis

Search GEO for disease gene expression data for Acute Cholangitis.

Pathways for Acute Cholangitis

Pathways related to Acute Cholangitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.09 CRP IL6
2 10.65 IL1RN IL6
3 9.9 CRP IL6

GO Terms for Acute Cholangitis

Biological processes related to Acute Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.54 CRP IL1RN IL6
2 response to glucocorticoid GO:0051384 9.32 IL1RN IL6
3 humoral immune response GO:0006959 9.26 IL6 TREM1
4 acute-phase response GO:0006953 9.16 CRP IL6
5 negative regulation of lipid storage GO:0010888 8.96 CRP IL6
6 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 8.62 IL1RN IL6

Sources for Acute Cholangitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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