MCID: ACT028
MIFTS: 31

Acute Closed-Angle Glaucoma

Categories: Eye diseases

Aliases & Classifications for Acute Closed-Angle Glaucoma

MalaCards integrated aliases for Acute Closed-Angle Glaucoma:

Name: Acute Closed-Angle Glaucoma 12 15
Acute Angle-Closure Glaucoma 12 74

Classifications:



External Ids:

Disease Ontology 12 DOID:13862
ICD9CM 36 365.22
SNOMED-CT 69 30041005
ICD10 34 H40.21
UMLS 74 C0154946

Summaries for Acute Closed-Angle Glaucoma

MalaCards based summary : Acute Closed-Angle Glaucoma, also known as acute angle-closure glaucoma, is related to neuropathy and retinal detachment. An important gene associated with Acute Closed-Angle Glaucoma is CTSA (Cathepsin A). The drugs Topiramate and Anticonvulsants have been mentioned in the context of this disorder. Affiliated tissues include eye, lung and endothelial, and related phenotype is pigmentation.

Related Diseases for Acute Closed-Angle Glaucoma

Diseases in the Acute Closed-Angle Glaucoma family:

Chronic Closed-Angle Glaucoma

Diseases related to Acute Closed-Angle Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 neuropathy 10.4
2 retinal detachment 10.3
3 uveitis 10.3
4 optic nerve disease 10.3
5 nonarteritic anterior ischemic optic neuropathy 10.2
6 retinitis pigmentosa 10.2
7 macular degeneration, age-related, 1 10.2
8 leber congenital amaurosis 4 10.2
9 cataract 10.2
10 ischemic optic neuropathy 10.2
11 leukemia 10.2
12 hypopyon 10.2
13 myopia 10.2
14 vogt-koyanagi-harada disease 10.2
15 miller fisher syndrome 10.2
16 melanoma 10.2
17 retinitis 10.2
18 headache 10.2
19 exudative vitreoretinopathy 1 10.1
20 melanoma, uveal 10.1
21 sturge-weber syndrome 10.1
22 von hippel-lindau syndrome 10.1
23 moyamoya disease 1 10.1
24 pseudoxanthoma elasticum 10.1
25 coats disease 10.1
26 choroideremia 10.1
27 yemenite deaf-blind hypopigmentation syndrome 10.1
28 granulomatosis with polyangiitis 10.1
29 aspergillosis 10.1
30 dengue virus 10.1
31 mucopolysaccharidosis-plus syndrome 10.1
32 chronic myelomonocytic leukemia 10.1
33 dengue disease 10.1
34 retinal ischemia 10.1
35 invasive aspergillosis 10.1
36 weill-marchesani syndrome 10.1
37 isolated ectopia lentis 10.1
38 renal hypertension 10.1
39 hypospadias 10.1
40 lens subluxation 10.1
41 ischemic neuropathy 10.1
42 guillain-barre syndrome 10.1
43 scleritis 10.1
44 posterior scleritis 10.1
45 chronic closed-angle glaucoma 10.1
46 ischemia 10.1
47 hyperglycemia 10.1
48 blepharospasm 10.1
49 acquired immunodeficiency syndrome 10.1
50 macular holes 10.1

Comorbidity relations with Acute Closed-Angle Glaucoma via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Acute Closed-Angle Glaucoma:



Diseases related to Acute Closed-Angle Glaucoma

Symptoms & Phenotypes for Acute Closed-Angle Glaucoma

MGI Mouse Phenotypes related to Acute Closed-Angle Glaucoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 pigmentation MP:0001186 8.62 BEST1 CHM

Drugs & Therapeutics for Acute Closed-Angle Glaucoma

Drugs for Acute Closed-Angle Glaucoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Topiramate Approved Phase 4 97240-79-4 5284627
2 Anticonvulsants Phase 4,Not Applicable
3 Hypoglycemic Agents Phase 4
4
Racepinephrine Approved Phase 2, Phase 3 329-65-7 838
5
Epinephrine Approved, Vet_approved Phase 2, Phase 3 51-43-4 5816
6 Bronchodilator Agents Phase 2, Phase 3
7 Adrenergic Agonists Phase 2, Phase 3
8 Neurotransmitter Agents Phase 2, Phase 3
9 Adrenergic alpha-Agonists Phase 2, Phase 3
10 Anti-Asthmatic Agents Phase 2, Phase 3
11 Epinephryl borate Phase 2, Phase 3
12 Sympathomimetics Phase 2, Phase 3
13 Peripheral Nervous System Agents Phase 2, Phase 3
14 Respiratory System Agents Phase 2, Phase 3
15 Vasoconstrictor Agents Phase 2, Phase 3
16 Adrenergic Agents Phase 2, Phase 3
17 Mydriatics Phase 2, Phase 3
18 Autonomic Agents Phase 2, Phase 3
19 Adrenergic beta-Agonists Phase 2, Phase 3
20
Mannitol Approved, Investigational 69-65-8 6251 453
21
Acetazolamide Approved, Vet_approved Not Applicable 59-66-5 1986
22
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
23
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
24 Natriuretic Agents ,Not Applicable
25 diuretics ,Not Applicable
26 Carbonic Anhydrase Inhibitors Not Applicable
27 Hormones, Hormone Substitutes, and Hormone Antagonists
28 Hormones
29 Gastrointestinal Agents
30 Antiemetics
31 glucocorticoids
32 Antineoplastic Agents, Hormonal
33 Anti-Inflammatory Agents
34 BB 1101
35 Hormone Antagonists

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Relationship Between Topiramate Use and Ocular Angle Status Unknown status NCT00153699 Phase 4 Topiramate
2 Prophylactic Topical Epinephrine to Reduce Bleeding in Transbronchial Lung Biopsies Recruiting NCT03126968 Phase 2, Phase 3 Topical epinephrine;Placebos
3 Phase IIA Double-Masked Randomized Sham-Controlled Trial of QPI-1007 Delivered by a Single Intravitreal Injection to Subjects With Acute Primary Angle-Closure Glaucoma (APACG) Completed NCT01965106 Phase 2 QPI-1007 Injection;(including placebo)
4 Angle Closure (Glaucoma) in Caucasians Unknown status NCT02054403
5 Comparison of Anterior Chamber Paracentesis and Conventional Mannitol Infusion in Patients With Primary Acute Angle-closure Glaucoma Completed NCT01266343
6 Immediate Anterior Chamber Paracentesis With A 30-Gauge Needle for Acute Primary Angle - Closure Completed NCT01923454 Not Applicable Acetazolamide
7 Sequential Laser Iridotomy Using Argon and Q-Switched 532 nm Frequency Doubled Neodymium Yag Laser: A Pilot Study Completed NCT00452998 Not Applicable
8 Chart Review: Drug Utilization Study in Participants Who Received Ozurdex™ (Dexamethasone Intravitreal Implant) 0.7 mg Injections for Visual Impairment Due to Diabetic Macular Edema (DME) Active, not recruiting NCT03889444

Search NIH Clinical Center for Acute Closed-Angle Glaucoma

Genetic Tests for Acute Closed-Angle Glaucoma

Anatomical Context for Acute Closed-Angle Glaucoma

MalaCards organs/tissues related to Acute Closed-Angle Glaucoma:

42
Eye, Lung, Endothelial, Bone, Testes

Publications for Acute Closed-Angle Glaucoma

Articles related to Acute Closed-Angle Glaucoma:

(show top 50) (show all 272)
# Title Authors Year
1
Acute Angle Closure Glaucoma in Von Hippel-Lindau Syndrome. ( 31005188 )
2019
2
Primary Acute Angle-Closure Glaucoma: Three-Dimensional Reconstruction Imaging of Optic Nerve Heard Structure in Based on Optical Coherence Tomography (OCT). ( 31096262 )
2019
3
Acute Angle-Closure Glaucoma Secondary to a Phakic Intraocular Lens, an Ophthalmic Emergency. ( 31061970 )
2019
4
Bilateral Acute Angle-Closure Glaucoma after Macular Hole Surgery. ( 30746920 )
2019
5
Postoperative Acute Angle-Closure Glaucoma: A Rare but Serious Complication: A Case Report. ( 30633003 )
2019
6
A frameshift mutation in the CHM gene causes choroideremia with acute angle‑closure glaucoma. ( 29620233 )
2018
7
Acute Angle-closure Glaucoma as a First Presentation of Coats' Disease: A Case Report. ( 29176335 )
2018
8
Endoscopic Goniosynechialysis for Acute Angle Closure Glaucoma Following Descemet's Stripping Automated Endothelial Keratoplasty. ( 30473604 )
2018
9
A Novel Association between Oxybutynin Use and Bilateral Acute Angle Closure Glaucoma: A Case Report and Literature Review. ( 30087808 )
2018
10
Acute Angle-Closure Glaucoma Caused by Venlafaxine. ( 29893371 )
2018
11
Acute angle closure glaucoma? ( 29665201 )
2018
12
Acute Angle-Closure Glaucoma. ( 29514027 )
2018
13
Bilateral acute angle-closure glaucoma following tramadol subcutaneous administration. ( 29454329 )
2018
14
Acute Angle-closure Glaucoma Associated With Aripiprazole in the Setting of Plateau Iris Configuration. ( 29189543 )
2018
15
Primary acute angle-closure glaucoma complicating ciliochoroidal detachment: report of four cases and review of the literature. ( 29170973 )
2018
16
Bilateral acute angle closure glaucoma and myopic shift by topiramate-induced ciliochoroidal effusion: case report and literature review. ( 29063980 )
2018
17
An uncommon case of intermittent Pourfour du Petit Syndrome associated with acute angle-closure glaucoma successfully treated by laser iridotomy. ( 28674857 )
2018
18
Miller Fisher syndrome with acute angle-closure glaucoma as the first manifestation: A case report. ( 29390338 )
2017
19
Acute Angle Closure Glaucoma in a Patient with Pseudoxanthoma Elasticum. ( 28914006 )
2017
20
Bilateral acute angle-closure glaucoma induced by duloxetine. ( 29870629 )
2017
21
An unusual case of acute angle-closure glaucoma following deep anterior lamellar keratoplasty using the "big bubble" technique. ( 29260096 )
2017
22
Acute angle closure glaucoma - A potential blind spot in critical care. ( 29118839 )
2017
23
A Rare Case of Topiramate Induced Secondary Acute Angle Closure Glaucoma. ( 28764211 )
2017
24
Acute angle closure glaucoma secondary to polypoidal choroidal vasculopathy - a devastating complication. ( 28154791 )
2017
25
Course of serum autoantibodies in patients after acute angle-closure glaucoma attack. ( 27758063 )
2017
26
Atypical Presentation of Acute Angle-Closure Glaucoma in Maroteaux-Lamy Mucopolysaccharidosis with Patent Prophylactic Laser Peripheral Iridotomy: A Case Report. ( 29035183 )
2017
27
Bilateral acute closed angle glaucoma associated with the discontinuation of escitalopram: a case report. ( 27660499 )
2016
28
Bilateral acute angle-closure glaucoma as a first presentation of granulomatosis with polyangiitis (Wegener's). ( 27982217 )
2016
29
Refractory acute angle-closure glaucoma with retinal ischemia: January consultation #1. ( 26948794 )
2016
30
Acute angle-closure glaucoma in a highly myopic patient secondary to Weill-Marchesani syndrome: histopathologic lens features. ( 26966104 )
2016
31
Safety in Treating Primary Acute Angle-closure Glaucoma under High Intraocular Pressure by Compound Trabeculectomy. ( 28412683 )
2016
32
Bilateral, Simultaneous, Acute Angle Closure Glaucoma in Pseudophakia Induced by Chlorthalidone. ( 27274878 )
2016
33
Oblique Flashlight Test: Lighting Up Acute Angle-Closure Glaucoma. ( 27173500 )
2016
34
Association of Selective Serotonin Reuptake Inhibitor Use and Acute Angle-Closure Glaucoma. ( 27135704 )
2016
35
Retraction: Bilateral acute angle closure glaucoma following a snake bite: Are we missing it? ( 27076740 )
2016
36
Bilateral acute angle closure glaucoma following a snake bite: Are we missing it? ( 26955216 )
2016
37
Unilateral Acute Angle-Closure Glaucoma After Lumbar Spine Surgery: A Case Report and Systematic Review of the Literature. ( 26571166 )
2016
38
Unilateral Acute Closed-Angle Glaucoma After Elective Lumbar Surgery Reveals Multiple Intracranial Aneurysms. A Case Report and Discussion on Workup of Differential Diagnoses. ( 25959248 )
2015
39
Acute angle closure glaucoma after hypospadias surgery: A vision-threatening complication of oxybutynin. ( 26166994 )
2015
40
Acute angle-closure glaucoma in a patient with miller fisher syndrome without pupillary dysfunction. ( 25393040 )
2015
41
Acute angle-closure glaucoma in retinopathy of prematurity following pupil dilation. ( 26253103 )
2015
42
A review of drug-induced acute angle closure glaucoma for non-ophthalmologists. ( 26535174 )
2015
43
Acute angle closure glaucoma precipitated by olanzapine. ( 26376106 )
2015
44
Should anesthesiologists be concerned with acute angle closure glaucoma? ( 26061458 )
2015
45
PAX6 Expression and Retinal Cell Death in a Transgenic Mouse Model for Acute Angle-Closure Glaucoma. ( 25827297 )
2015
46
Unilateral Optic Neuropathy and Acute Angle-Closure Glaucoma following Snake Envenomation. ( 25705536 )
2015
47
Fibrous proliferation into anterior segment after acute angle-closure glaucoma. ( 25411932 )
2015
48
Bilateral severe anterior uveitis and acute angle-closure glaucoma following topiramate use for migraine crisis. ( 24771187 )
2014
49
Oseltamivir (Tamiflu)-induced bilateral acute angle closure glaucoma and transient myopia. ( 23571265 )
2014
50
Acute angle-closure glaucoma after general anesthesia for bone grafting. ( 25517552 )
2014

Variations for Acute Closed-Angle Glaucoma

Expression for Acute Closed-Angle Glaucoma

Search GEO for disease gene expression data for Acute Closed-Angle Glaucoma.

Pathways for Acute Closed-Angle Glaucoma

GO Terms for Acute Closed-Angle Glaucoma

Biological processes related to Acute Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 8.62 BEST1 CHM

Sources for Acute Closed-Angle Glaucoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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