MCID: ACT028
MIFTS: 30

Acute Closed-Angle Glaucoma

Categories: Eye diseases

Aliases & Classifications for Acute Closed-Angle Glaucoma

MalaCards integrated aliases for Acute Closed-Angle Glaucoma:

Name: Acute Closed-Angle Glaucoma 12 15
Acute Angle-Closure Glaucoma 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:13862
ICD10 33 H40.21
ICD9CM 35 365.22
SNOMED-CT 68 30041005
UMLS 73 C0154946

Summaries for Acute Closed-Angle Glaucoma

MalaCards based summary : Acute Closed-Angle Glaucoma, also known as acute angle-closure glaucoma, is related to optic nerve disease and chronic closed-angle glaucoma. An important gene associated with Acute Closed-Angle Glaucoma is MFRP (Membrane Frizzled-Related Protein). The drugs Topiramate and Neuroprotective Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and bone, and related phenotype is pigmentation.

Related Diseases for Acute Closed-Angle Glaucoma

Diseases in the Acute Closed-Angle Glaucoma family:

Chronic Closed-Angle Glaucoma

Diseases related to Acute Closed-Angle Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 optic nerve disease 30.5 MFRP OPTN
2 chronic closed-angle glaucoma 30.2 CTSA OPTN
3 neuropathy 10.4
4 retinal detachment 10.3
5 uveitis 10.3
6 nonarteritic anterior ischemic optic neuropathy 10.2
7 retinitis pigmentosa 10.2
8 macular degeneration, age-related, 1 10.2
9 leber congenital amaurosis 4 10.2
10 cataract 10.2
11 ischemic optic neuropathy 10.2
12 hypopyon 10.2
13 myopia 10.2
14 vogt-koyanagi-harada disease 10.2
15 miller fisher syndrome 10.2
16 melanoma 10.2
17 retinitis 10.2
18 headache 10.2
19 exudative vitreoretinopathy 1 10.1
20 melanoma, uveal 10.1
21 sturge-weber syndrome 10.1
22 temporal arteritis 10.1
23 moyamoya disease 1 10.1
24 pseudoxanthoma elasticum 10.1
25 coats disease 10.1
26 granulomatosis with polyangiitis 10.1
27 aspergillosis 10.1
28 dengue virus 10.1
29 mucopolysaccharidosis-plus syndrome 10.1
30 chronic myelomonocytic leukemia 10.1
31 dengue disease 10.1
32 retinal ischemia 10.1
33 invasive aspergillosis 10.1
34 weill-marchesani syndrome 10.1
35 isolated ectopia lentis 10.1
36 renal hypertension 10.1
37 hypospadias 10.1
38 lens subluxation 10.1
39 ischemic neuropathy 10.1
40 guillain-barre syndrome 10.1
41 scleritis 10.1
42 posterior scleritis 10.1
43 ischemia 10.1
44 hyperglycemia 10.1
45 blepharospasm 10.1
46 acquired immunodeficiency syndrome 10.1
47 cocaine abuse 10.1
48 herpes zoster 10.1
49 vasculitis 10.1
50 anterior uveitis 10.1

Comorbidity relations with Acute Closed-Angle Glaucoma via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Acute Closed-Angle Glaucoma:



Diseases related to Acute Closed-Angle Glaucoma

Symptoms & Phenotypes for Acute Closed-Angle Glaucoma

MGI Mouse Phenotypes related to Acute Closed-Angle Glaucoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 pigmentation MP:0001186 8.8 CHM HSD17B1 MFRP

Drugs & Therapeutics for Acute Closed-Angle Glaucoma

Drugs for Acute Closed-Angle Glaucoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Topiramate Approved Phase 4 97240-79-4 5284627
2 Neuroprotective Agents Phase 4
3 Anti-Obesity Agents Phase 4
4 Anticonvulsants Phase 4,Not Applicable
5 Protective Agents Phase 4
6
Epinephrine Approved, Vet_approved Phase 2, Phase 3 51-43-4 5816
7
Racepinephrine Approved Phase 2, Phase 3 329-65-7 838
8 Adrenergic beta-Agonists Phase 2, Phase 3
9 Vasoconstrictor Agents Phase 2, Phase 3
10 Autonomic Agents Phase 2, Phase 3
11 Anti-Asthmatic Agents Phase 2, Phase 3
12 Mydriatics Phase 2, Phase 3
13 Adrenergic Agonists Phase 2, Phase 3
14 Adrenergic alpha-Agonists Phase 2, Phase 3
15 Respiratory System Agents Phase 2, Phase 3
16 Sympathomimetics Phase 2, Phase 3
17 Neurotransmitter Agents Phase 2, Phase 3
18 Epinephryl borate Phase 2, Phase 3
19 Adrenergic Agents Phase 2, Phase 3
20 Peripheral Nervous System Agents Phase 2, Phase 3
21 Bronchodilator Agents Phase 2, Phase 3
22
Mannitol Approved, Investigational 69-65-8 453 6251
23
Acetazolamide Approved, Vet_approved Not Applicable 59-66-5 1986
24 diuretics ,Not Applicable
25 Natriuretic Agents ,Not Applicable
26 Carbonic Anhydrase Inhibitors Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Relationship Between Topiramate Use and Ocular Angle Status Unknown status NCT00153699 Phase 4 Topiramate
2 Prophylactic Topical Epinephrine to Reduce Bleeding in Transbronchial Lung Biopsies Recruiting NCT03126968 Phase 2, Phase 3 Topical epinephrine;Placebos
3 Phase IIA Double-Masked Randomized Sham-Controlled Trial of QPI-1007 Delivered by a Single Intravitreal Injection to Subjects With Acute Primary Angle-Closure Glaucoma (APACG) Completed NCT01965106 Phase 2 QPI-1007 Injection;(including placebo)
4 Angle Closure (Glaucoma) in Caucasians Unknown status NCT02054403
5 Comparison of Anterior Chamber Paracentesis and Conventional Mannitol Infusion in Patients With Primary Acute Angle-closure Glaucoma Completed NCT01266343
6 Immediate Anterior Chamber Paracentesis With A 30-Gauge Needle for Acute Primary Angle - Closure Completed NCT01923454 Not Applicable Acetazolamide
7 Sequential Laser Iridotomy Using Argon and Q-Switched 532 nm Frequency Doubled Neodymium Yag Laser: A Pilot Study Completed NCT00452998 Not Applicable

Search NIH Clinical Center for Acute Closed-Angle Glaucoma

Genetic Tests for Acute Closed-Angle Glaucoma

Anatomical Context for Acute Closed-Angle Glaucoma

MalaCards organs/tissues related to Acute Closed-Angle Glaucoma:

41
Eye, Endothelial, Bone, Testes

Publications for Acute Closed-Angle Glaucoma

Articles related to Acute Closed-Angle Glaucoma:

(show top 50) (show all 266)
# Title Authors Year
1
Acute Angle-closure Glaucoma as a First Presentation of Coats' Disease: A Case Report. ( 29176335 )
2018
2
An uncommon case of intermittent Pourfour du Petit Syndrome associated with acute angle-closure glaucoma successfully treated by laser iridotomy. ( 28674857 )
2018
3
Bilateral acute angle closure glaucoma and myopic shift by topiramate-induced ciliochoroidal effusion: case report and literature review. ( 29063980 )
2018
4
Primary acute angle-closure glaucoma complicating ciliochoroidal detachment: report of four cases and review of the literature. ( 29170973 )
2018
5
Acute Angle-closure Glaucoma Associated With Aripiprazole in the Setting of Plateau Iris Configuration. ( 29189543 )
2018
6
Bilateral acute angle-closure glaucoma following tramadol subcutaneous administration. ( 29454329 )
2018
7
Acute Angle-Closure Glaucoma. ( 29514027 )
2018
8
Acute angle closure glaucoma? ( 29665201 )
2018
9
Acute Angle-Closure Glaucoma Caused by Venlafaxine. ( 29893371 )
2018
10
A Novel Association between Oxybutynin Use and Bilateral Acute Angle Closure Glaucoma: A Case Report and Literature Review. ( 30087808 )
2018
11
Endoscopic Goniosynechialysis for Acute Angle Closure Glaucoma Following Descemet's Stripping Automated Endothelial Keratoplasty. ( 30473604 )
2018
12
Miller Fisher syndrome with acute angle-closure glaucoma as the first manifestation: A case report. ( 29390338 )
2017
13
Acute Angle Closure Glaucoma in a Patient with Pseudoxanthoma Elasticum. ( 28914006 )
2017
14
Course of serum autoantibodies in patients after acute angle-closure glaucoma attack. ( 27758063 )
2017
15
Acute angle closure glaucoma secondary to polypoidal choroidal vasculopathy - a devastating complication. ( 28154791 )
2017
16
A Rare Case of Topiramate Induced Secondary Acute Angle Closure Glaucoma. ( 28764211 )
2017
17
Acute angle closure glaucoma - A potential blind spot in critical care. ( 29118839 )
2017
18
An unusual case of acute angle-closure glaucoma following deep anterior lamellar keratoplasty using the "big bubble" technique. ( 29260096 )
2017
19
Bilateral acute angle-closure glaucoma induced by duloxetine. ( 29870629 )
2017
20
Atypical Presentation of Acute Angle-Closure Glaucoma in Maroteaux-Lamy Mucopolysaccharidosis with Patent Prophylactic Laser Peripheral Iridotomy: A Case Report. ( 29035183 )
2017
21
Retraction: Bilateral acute angle closure glaucoma following a snake bite: Are we missing it? ( 27076740 )
2016
22
Oblique Flashlight Test: Lighting Up Acute Angle-Closure Glaucoma. ( 27173500 )
2016
23
Association of Selective Serotonin Reuptake Inhibitor Use and Acute Angle-Closure Glaucoma. ( 27135704 )
2016
24
Bilateral acute angle closure glaucoma following a snake bite: Are we missing it? ( 26955216 )
2016
25
Bilateral acute closed angle glaucoma associated with the discontinuation of escitalopram: a case report. ( 27660499 )
2016
26
Acute angle-closure glaucoma in a highly myopic patient secondary to Weill-Marchesani syndrome: histopathologic lens features. ( 26966104 )
2016
27
Refractory acute angle-closure glaucoma with retinal ischemia: January consultation #1. ( 26948794 )
2016
28
Bilateral acute angle-closure glaucoma as a first presentation of granulomatosis with polyangiitis (Wegener's). ( 27982217 )
2016
29
Unilateral Acute Angle-Closure Glaucoma After Lumbar Spine Surgery: A Case Report and Systematic Review of the Literature. ( 26571166 )
2016
30
Bilateral, Simultaneous, Acute Angle Closure Glaucoma in Pseudophakia Induced by Chlorthalidone. ( 27274878 )
2016
31
Safety in Treating Primary Acute Angle-closure Glaucoma under High Intraocular Pressure by Compound Trabeculectomy. ( 28412683 )
2016
32
Unilateral Acute Closed-Angle Glaucoma After Elective Lumbar Surgery Reveals Multiple Intracranial Aneurysms. A Case Report and Discussion on Workup of Differential Diagnoses. ( 25959248 )
2015
33
Acute angle closure glaucoma after hypospadias surgery: A vision-threatening complication of oxybutynin. ( 26166994 )
2015
34
Acute angle-closure glaucoma in retinopathy of prematurity following pupil dilation. ( 26253103 )
2015
35
Unilateral Optic Neuropathy and Acute Angle-Closure Glaucoma following Snake Envenomation. ( 25705536 )
2015
36
PAX6 Expression and Retinal Cell Death in a Transgenic Mouse Model for Acute Angle-Closure Glaucoma. ( 25827297 )
2015
37
Should anesthesiologists be concerned with acute angle closure glaucoma? ( 26061458 )
2015
38
Acute angle closure glaucoma precipitated by olanzapine. ( 26376106 )
2015
39
A review of drug-induced acute angle closure glaucoma for non-ophthalmologists. ( 26535174 )
2015
40
Fibrous proliferation into anterior segment after acute angle-closure glaucoma. ( 25411932 )
2015
41
Acute Angle-Closure Glaucoma in a Patient With Miller Fisher Syndrome Without Pupillary Dysfunction. ( 25393040 )
2014
42
Bilateral severe anterior uveitis and acute angle-closure glaucoma following topiramate use for migraine crisis. ( 24771187 )
2014
43
Microcoaxial phacoemulsification combined with viscogoniosynechialysis for patients with refractory acute angle-closure glaucoma. ( 22895523 )
2014
44
Probable Association of an Attack of Bilateral Acute Angle-Closure Glaucoma With Duloxetine. ( 24732786 )
2014
45
Bilateral acute angle closure glaucoma precipitated by over the counter oral decongestant. ( 24790890 )
2014
46
Intermittent acute angle closure glaucoma and chronic angle closure following topiramate use with plateau iris configuration. ( 25114497 )
2014
47
Do we really need to panic in all acute vision loss in ICU? Acute angle-closure glaucoma. ( 25252529 )
2014
48
Bilateral acute angle closure glaucoma associated with hydrochlorothiazide-induced hyponatraemia. ( 25477363 )
2014
49
Acute angle closure glaucoma with capilllary leak syndrome following snake bite. ( 25478432 )
2014
50
Acute angle-closure glaucoma after general anesthesia for bone grafting. ( 25517552 )
2014

Variations for Acute Closed-Angle Glaucoma

Expression for Acute Closed-Angle Glaucoma

Search GEO for disease gene expression data for Acute Closed-Angle Glaucoma.

Pathways for Acute Closed-Angle Glaucoma

GO Terms for Acute Closed-Angle Glaucoma

Biological processes related to Acute Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 8.62 CHM MFRP

Molecular functions related to Acute Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Rab GTPase binding GO:0017137 8.62 CHM OPTN

Sources for Acute Closed-Angle Glaucoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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