MCID: ACT028
MIFTS: 29

Acute Closed-Angle Glaucoma

Categories: Eye diseases

Aliases & Classifications for Acute Closed-Angle Glaucoma

MalaCards integrated aliases for Acute Closed-Angle Glaucoma:

Name: Acute Closed-Angle Glaucoma 12 15
Acute Angle-Closure Glaucoma 12 72

Classifications:



External Ids:

Disease Ontology 12 DOID:13862
ICD9CM 35 365.22
SNOMED-CT 68 30041005
ICD10 33 H40.21
UMLS 72 C0154946

Summaries for Acute Closed-Angle Glaucoma

MalaCards based summary : Acute Closed-Angle Glaucoma, also known as acute angle-closure glaucoma, is related to intraocular pressure quantitative trait locus and cataract. An important gene associated with Acute Closed-Angle Glaucoma is BEST1 (Bestrophin 1). The drugs Mannitol and Lutein have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and testes.

Related Diseases for Acute Closed-Angle Glaucoma

Diseases in the Acute Closed-Angle Glaucoma family:

Chronic Closed-Angle Glaucoma

Diseases related to Acute Closed-Angle Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)
# Related Disease Score Top Affiliating Genes
1 intraocular pressure quantitative trait locus 10.8
2 cataract 10.6
3 yemenite deaf-blind hypopigmentation syndrome 10.6
4 corneal edema 10.6
5 retinal detachment 10.5
6 myopia 10.5
7 headache 10.5
8 migraine with or without aura 1 10.5
9 optic nerve disease 10.5
10 ptosis 10.4
11 uveitis 10.4
12 chronic closed-angle glaucoma 10.4
13 neuropathy 10.4
14 macular degeneration, age-related, 1 10.3
15 miller fisher syndrome 10.3
16 melanoma, uveal 10.3
17 nonarteritic anterior ischemic optic neuropathy 10.3
18 retinitis pigmentosa 10.3
19 ataxia and polyneuropathy, adult-onset 10.3
20 kearns-sayre syndrome 10.3
21 neuroretinitis 10.3
22 hypopyon 10.3
23 lens subluxation 10.3
24 vogt-koyanagi-harada disease 10.3
25 melanoma 10.3
26 retinitis 10.3
27 ocular hypertension 10.3
28 exophthalmos 10.3
29 47,xyy 10.3
30 autonomic dysfunction 10.3
31 alcohol dependence 10.1
32 major affective disorder 1 10.1
33 exudative vitreoretinopathy 1 10.1
34 sturge-weber syndrome 10.1
35 von hippel-lindau syndrome 10.1
36 moyamoya disease 1 10.1
37 pseudoxanthoma elasticum 10.1
38 coats disease 10.1
39 choroideremia 10.1
40 astigmatism 10.1
41 pars planitis 10.1
42 pulmonary disease, chronic obstructive 10.1
43 granulomatosis with polyangiitis 10.1
44 human immunodeficiency virus type 1 10.1
45 microvascular complications of diabetes 5 10.1
46 aspergillosis 10.1
47 hydrops, lactic acidosis, and sideroblastic anemia 10.1
48 mucopolysaccharidosis-plus syndrome 10.1
49 invasive aspergillosis 10.1
50 weill-marchesani syndrome 10.1

Comorbidity relations with Acute Closed-Angle Glaucoma via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Acute Closed-Angle Glaucoma:



Diseases related to Acute Closed-Angle Glaucoma

Symptoms & Phenotypes for Acute Closed-Angle Glaucoma

Drugs & Therapeutics for Acute Closed-Angle Glaucoma

DrugBank drugs 16 :

# Drug Name Indication DrugBank ID
1 Carbamoylcholine Primarily used in the treatment of glaucoma, but is also used during ophthalmic surgery. DB00411
2 Methazolamide For treatment of chronic open-angle glaucoma and acute angle-closure glaucoma DB00703
3 Pilocarpine For the treatment of radiation-induced dry mouth (xerostomia) and symptoms of dry mouth in patients with Sjögrens syndrome. DB01085

Drugs for Acute Closed-Angle Glaucoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mannitol Approved, Investigational 69-65-8 453 6251
2
Lutein Approved, Investigational, Nutraceutical 127-40-2 6433159
3 Natriuretic Agents
4 diuretics
5 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase IIA Double-Masked Randomized Sham-Controlled Trial of QPI-1007 Delivered by a Single Intravitreal Injection to Subjects With Acute Primary Angle-Closure Glaucoma (APACG) Completed NCT01965106 Phase 2 QPI-1007 Injection;(including placebo)
2 Structural and Functional Parameters in Caucasian Patients With Angle Closure on SS-OCT Unknown status NCT02054403
3 Comparison of Anterior Chamber Paracentesis and Conventional Mannitol Infusion in Patients With Primary Acute Angle-closure Glaucoma Completed NCT01266343
4 Incidence of Visual Symptom Following Laser (Nd:YAG ) Peripheral Iridotomy (LPI) in Relation to Position of LPI Completed NCT01758237
5 The Effect of Ocular Massage on the Management of Elevated Intraocular Pressure After Acute Angle Closure Completed NCT02539758
6 The Effect of Lutein-enriched-egg Beverage on Progression of Age-related Macular Degeneration, a Randomized Trial Completed NCT00902408
7 Short-term Outcomes of Iridoplasty for Persistent Angle Closure Despite Patent Iridotomies An Anterior Segment Optical Coherence Tomography Study Completed NCT02199158
8 Optic Nerve Compliance Study Completed NCT00328835
9 Angle Closure: Laser Iridotomy Versus Phacoemulsification Study (ACLIPS)- A Study of Acute Primary Angle Closure Glaucoma Comparing Two Treatment Modalities: Laser Peripheral vs Phacoemulsification With Posterior Intraocular Lens Implant Completed NCT00350428

Search NIH Clinical Center for Acute Closed-Angle Glaucoma

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Carbamoylcholine
Methazolamide
Pilocarpine

Genetic Tests for Acute Closed-Angle Glaucoma

Anatomical Context for Acute Closed-Angle Glaucoma

MalaCards organs/tissues related to Acute Closed-Angle Glaucoma:

41
Eye, Endothelial, Testes, Bone

Publications for Acute Closed-Angle Glaucoma

Articles related to Acute Closed-Angle Glaucoma:

(show top 50) (show all 602)
# Title Authors PMID Year
1
Ciliochoroidal effusion in topiramate-induced bilateral acute angle closure glaucoma. 38
31436195 2019
2
Aqueous humor levels of TGFβ2 and SFRP1 in different types of glaucoma. 38
31382918 2019
3
A new rhodopsin R135W mutation induces endoplasmic reticulum stress and apoptosis in retinal pigment epithelial cells. 38
30635925 2019
4
Rare cause of acute angle-closure glaucoma in an elderly man. 38
31326909 2019
5
Association of Gabapentin or Pregabalin use and Incidence of Acute Angle-closure Glaucoma. 38
31335554 2019
6
Association between use of benzodiazepines and occurrence of acute angle-closure glaucoma in the elderly: A population-based study. 38
31126405 2019
7
Acute angle-closure glaucoma with choroidal effusion revealing a hantavirus infection: Description of ultrasound biomicroscopy imagery and optical coherence tomography Visante. 38
31256684 2019
8
Non-prescription cold and flu medication-induced transient myopia with uveal effusion: case report. 38
31242876 2019
9
A Convergence of Ophthalmic and Life-threatening Emergencies: Acute Angle Closure Glaucoma and Subarachnoid Hemorrhage. 38
31233457 2019
10
Postoperative Acute Angle-Closure Glaucoma: A Rare but Serious Complication: A Case Report. 38
31162162 2019
11
Impact of acute intraocular pressure elevation on the visual acuity of non-human primates. 38
31178426 2019
12
AUTOSOMAL DOMINANT VITREORETINOCHOROIDOPATHY: When Molecular Genetic Testing Helps Clinical Diagnosis. 38
29370033 2019
13
Acute Angle Closure Glaucoma in Von Hippel-Lindau Syndrome. 38
31005188 2019
14
Acute Angle-Closure Glaucoma Secondary to a Phakic Intraocular Lens, an Ophthalmic Emergency. 38
31061970 2019
15
Primary Acute Angle-Closure Glaucoma: Three-Dimensional Reconstruction Imaging of Optic Nerve Heard Structure in Based on Optical Coherence Tomography (OCT). 38
31096262 2019
16
Acute narrow-angle glaucoma induced by topiramate with acute myopia and macular striae: A case report. 38
30591244 2019
17
Evaluation and Management of the Emergency Department Headache. 38
30743289 2019
18
Bilateral Acute Angle-Closure Glaucoma after Macular Hole Surgery. 38
30746920 2019
19
Large choroidal melanoma presenting as neovascular glaucoma. 38
31293875 2019
20
[Effectiveness of the system for predicting the risk of developing an acute angle closure glaucoma attack]. 38
30830074 2019
21
Acute angle closure glaucoma from spontaneous massive subretinal hemorrhage. 38
31157157 2019
22
Postoperative Acute Angle-Closure Glaucoma: A Rare but Serious Complication: A Case Report. 38
30633003 2019
23
Combined treatment of phacoemulsification and single-port limited pars plana vitrectomy in acute angle-closure glaucoma. 38
31236355 2019
24
Bilateral acute angle closure glaucoma and myopic shift by topiramate-induced ciliochoroidal effusion: case report and literature review. 38
29063980 2018
25
Primary acute angle-closure glaucoma complicating ciliochoroidal detachment: report of four cases and review of the literature. 38
29170973 2018
26
Uveitis and acute glaucoma as first presenting symptoms of sarcoidosis in a healthy male. 38
30194022 2018
27
An uncommon case of intermittent Pourfour du Petit Syndrome associated with acute angle-closure glaucoma successfully treated by laser iridotomy. 38
28674857 2018
28
Early Phacoemulsification After Acute Angle Closure in Patients With Coexisting Cataract. 38
30005031 2018
29
A Novel Association between Oxybutynin Use and Bilateral Acute Angle Closure Glaucoma: A Case Report and Literature Review. 38
30087808 2018
30
Acute Glaucoma Attack Following Microvascular Decompression Surgery for Trigeminal Neuralgia. 38
29769452 2018
31
A frameshift mutation in the CHM gene causes choroideremia with acute angle‑closure glaucoma. 38
29620233 2018
32
[Blinding spontaneous suprachoroidal haemorrhage in anticoagulant taking wet-AMD patients]. 38
29888658 2018
33
Phacomorphic Angle-closure Following Silicone Oil Tamponade in a Pediatric Patient. 38
29613981 2018
34
Acute Angle-Closure Glaucoma Caused by Venlafaxine. 38
29893371 2018
35
Endoscopic Goniosynechialysis for Acute Angle Closure Glaucoma Following Descemet's Stripping Automated Endothelial Keratoplasty. 38
30473604 2018
36
Acute angle closure glaucoma? 38
29665201 2018
37
Acute Angle-Closure Glaucoma. 38
29514027 2018
38
Acute Angle-closure Glaucoma as a First Presentation of Coats' Disease: A Case Report. 38
29176335 2018
39
Bilateral acute angle-closure glaucoma following tramadol subcutaneous administration. 38
29454329 2018
40
Acute Angle-closure Glaucoma Associated With Aripiprazole in the Setting of Plateau Iris Configuration. 38
29189543 2018
41
ACUTE MYOPIA WITH ELEVATION OF INTRAOCULAR TENSION AS AN ADVERSE SIDE EFFECT OF ANTIDEPRESSANT MEDICATION. 38
30441952 2018
42
Best Vitelliform Macular Dystrophy. 38
30578502 2018
43
[Case report on choroidal effusion after oral acetazolamide administration: an unusual manifestation of a well-known idiosyncratic effect?] 38
29226716 2017
44
[Acute angle closure glaucoma as presenting sign of posterior segment inflammatory disease: Report of two cases]. 38
29122379 2017
45
Miller Fisher syndrome with acute angle-closure glaucoma as the first manifestation: A case report. 38
29390338 2017
46
Assessment, care and management of patients with red eye. 38
29210535 2017
47
Acute Angle Closure Glaucoma in a Patient with Pseudoxanthoma Elasticum. 38
28914006 2017
48
Oseltamivir (Tamiflu)-induced Bilateral Ciliochoroidal Effusion and Angle Closure Glaucoma: What Type of Idiosyncratic Reaction? 38
29090056 2017
49
An unusual case of acute angle-closure glaucoma following deep anterior lamellar keratoplasty using the "big bubble" technique. 38
29260096 2017
50
Bilateral acute angle-closure glaucoma induced by duloxetine. 38
29870629 2017

Variations for Acute Closed-Angle Glaucoma

Expression for Acute Closed-Angle Glaucoma

Search GEO for disease gene expression data for Acute Closed-Angle Glaucoma.

Pathways for Acute Closed-Angle Glaucoma

GO Terms for Acute Closed-Angle Glaucoma

Biological processes related to Acute Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 8.96 CHM BEST1
2 protein stabilization GO:0050821 8.62 PIN1 PEX19

Sources for Acute Closed-Angle Glaucoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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