MCID: ACT028
MIFTS: 28

Acute Closed-Angle Glaucoma

Categories: Eye diseases

Aliases & Classifications for Acute Closed-Angle Glaucoma

MalaCards integrated aliases for Acute Closed-Angle Glaucoma:

Name: Acute Closed-Angle Glaucoma 12 15
Acute Angle-Closure Glaucoma 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:13862
ICD10 33 H40.21
ICD9CM 35 365.22
SNOMED-CT 68 30041005
UMLS 73 C0154946

Summaries for Acute Closed-Angle Glaucoma

MalaCards based summary : Acute Closed-Angle Glaucoma, also known as acute angle-closure glaucoma, is related to optic nerve disease and neuropathy. An important gene associated with Acute Closed-Angle Glaucoma is MFRP (Membrane Frizzled-Related Protein). The drugs Topiramate and Anticonvulsants have been mentioned in the context of this disorder. Affiliated tissues include eye, lung and testes, and related phenotype is pigmentation.

Related Diseases for Acute Closed-Angle Glaucoma

Diseases in the Acute Closed-Angle Glaucoma family:

Chronic Closed-Angle Glaucoma

Diseases related to Acute Closed-Angle Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 optic nerve disease 30.2 MFRP OPTN
2 neuropathy 10.2
3 amblyopia 10.2 MFRP OPTN
4 primary angle-closure glaucoma 10.2 MFRP OPTN
5 nonarteritic anterior ischemic optic neuropathy 10.1
6 ischemic optic neuropathy 10.1
7 hypopyon 10.1
8 vogt-koyanagi-harada disease 10.1
9 miller fisher syndrome 10.1
10 retinitis 10.1
11 chronic closed-angle glaucoma 10.1 CTSA OPTN
12 retinal detachment 10.0
13 sturge-weber syndrome 10.0
14 pseudoxanthoma elasticum 10.0
15 coats disease 10.0
16 retinal ischemia 10.0
17 weill-marchesani syndrome 10.0
18 renal hypertension 10.0
19 lens subluxation 10.0
20 myopia 10.0
21 ischemic neuropathy 10.0
22 scleritis 10.0
23 posterior scleritis 10.0
24 ischemia 10.0
25 blepharospasm 10.0
26 cocaine abuse 10.0
27 weber syndrome 10.0
28 phacogenic glaucoma 10.0 OPTN PEX19
29 corneal endothelial dystrophy 10.0 CTSA OPTN
30 iris disease 9.9 OPTN PEX19
31 arteriovenous fistula 9.9
32 intracranial aneurysm 9.9
33 choroiditis 9.9
34 aneurysm 9.9
35 coloboma of macula 9.9 MFRP OPTN
36 lens disease 9.9 OPTN PEX19
37 nervous system disease 9.8 MFRP OPTN
38 retinal degeneration 9.1 CHM MFRP
39 ewing sarcoma 9.0 CHM MFRP OPTN

Comorbidity relations with Acute Closed-Angle Glaucoma via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Acute Closed-Angle Glaucoma:



Diseases related to Acute Closed-Angle Glaucoma

Symptoms & Phenotypes for Acute Closed-Angle Glaucoma

MGI Mouse Phenotypes related to Acute Closed-Angle Glaucoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 pigmentation MP:0001186 8.8 CHM HSD17B1 MFRP

Drugs & Therapeutics for Acute Closed-Angle Glaucoma

Drugs for Acute Closed-Angle Glaucoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Topiramate Approved Phase 4 97240-79-4 5284627
2 Anticonvulsants Phase 4,Not Applicable
3 Anti-Obesity Agents Phase 4
4 Neuroprotective Agents Phase 4
5 Protective Agents Phase 4
6
Epinephrine Approved, Vet_approved Phase 2, Phase 3 51-43-4 5816
7
Racepinephrine Approved Phase 2, Phase 3 329-65-7 838
8 Adrenergic Agents Phase 2, Phase 3
9 Adrenergic Agonists Phase 2, Phase 3
10 Adrenergic alpha-Agonists Phase 2, Phase 3
11 Adrenergic beta-Agonists Phase 2, Phase 3
12 Anti-Asthmatic Agents Phase 2, Phase 3
13 Autonomic Agents Phase 2, Phase 3
14 Bronchodilator Agents Phase 2, Phase 3
15 Epinephryl borate Phase 2, Phase 3
16 Mydriatics Phase 2, Phase 3
17 Neurotransmitter Agents Phase 2, Phase 3
18 Peripheral Nervous System Agents Phase 2, Phase 3
19 Respiratory System Agents Phase 2, Phase 3
20 Vasoconstrictor Agents Phase 2, Phase 3
21
Mannitol Approved, Investigational 69-65-8 453 6251
22
Acetazolamide Approved, Vet_approved Not Applicable 59-66-5 1986
23 diuretics ,Not Applicable
24 Natriuretic Agents ,Not Applicable
25 Carbonic Anhydrase Inhibitors Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Relationship Between Topiramate Use and Ocular Angle Status Unknown status NCT00153699 Phase 4 Topiramate
2 Prophylactic Topical Epinephrine to Reduce Bleeding in Transbronchial Lung Biopsies Recruiting NCT03126968 Phase 2, Phase 3 Topical epinephrine;Placebos
3 Phase IIA Double-Masked Randomized Sham-Controlled Trial of QPI-1007 Delivered by a Single Intravitreal Injection to Subjects With Acute Primary Angle-Closure Glaucoma (APACG) Completed NCT01965106 Phase 2 QPI-1007 Injection;(including placebo)
4 Angle Closure (Glaucoma) in Caucasians Unknown status NCT02054403
5 Comparison of Anterior Chamber Paracentesis and Conventional Mannitol Infusion in Patients With Primary Acute Angle-closure Glaucoma Completed NCT01266343
6 Immediate Anterior Chamber Paracentesis With A 30-Gauge Needle for Acute Primary Angle - Closure Completed NCT01923454 Not Applicable Acetazolamide
7 Sequential Laser Iridotomy Using Argon and Q-Switched 532 nm Frequency Doubled Neodymium Yag Laser: A Pilot Study Completed NCT00452998 Not Applicable

Search NIH Clinical Center for Acute Closed-Angle Glaucoma

Genetic Tests for Acute Closed-Angle Glaucoma

Anatomical Context for Acute Closed-Angle Glaucoma

MalaCards organs/tissues related to Acute Closed-Angle Glaucoma:

41
Eye, Lung, Testes

Publications for Acute Closed-Angle Glaucoma

Articles related to Acute Closed-Angle Glaucoma:

(show all 42)
# Title Authors Year
1
Acute Angle-closure Glaucoma as a First Presentation of Coats' Disease: A Case Report. ( 29176335 )
2018
2
Miller Fisher syndrome with acute angle-closure glaucoma as the first manifestation: A case report. ( 29390338 )
2017
3
Acute Angle Closure Glaucoma in a Patient with Pseudoxanthoma Elasticum. ( 28914006 )
2017
4
Retraction: Bilateral acute angle closure glaucoma following a snake bite: Are we missing it? ( 27076740 )
2016
5
Oblique Flashlight Test: Lighting Up Acute Angle-Closure Glaucoma. ( 27173500 )
2016
6
Association of Selective Serotonin Reuptake Inhibitor Use and Acute Angle-Closure Glaucoma. ( 27135704 )
2016
7
Bilateral acute angle closure glaucoma following a snake bite: Are we missing it? ( 26955216 )
2016
8
Bilateral acute closed angle glaucoma associated with the discontinuation of escitalopram: a case report. ( 27660499 )
2016
9
Acute angle-closure glaucoma in a highly myopic patient secondary to Weill-Marchesani syndrome: histopathologic lens features. ( 26966104 )
2016
10
Refractory acute angle-closure glaucoma with retinal ischemia: January consultation #1. ( 26948794 )
2016
11
Unilateral Acute Closed-Angle Glaucoma After Elective Lumbar Surgery Reveals Multiple Intracranial Aneurysms. A Case Report and Discussion on Workup of Differential Diagnoses. ( 25959248 )
2015
12
Acute Angle-Closure Glaucoma in a Patient With Miller Fisher Syndrome Without Pupillary Dysfunction. ( 25393040 )
2014
13
Oseltamivir (Tamiflu)-induced bilateral acute angle closure glaucoma and transient myopia. ( 23571265 )
2013
14
Bilateral nonarteritic anterior ischemic neuropathy following acute angle-closure glaucoma in a patient with iridoschisis: case report. ( 21670912 )
2011
15
Vogt-Koyanagi-Harada disease presenting as acute angle closure glaucoma at onset. ( 22452682 )
2011
16
Anterior segment optical coherence tomography findings of acute angle-closure glaucoma in Vogt-Koyanagi-Harada disease. ( 18661276 )
2008
17
Transgenic mice with ocular overexpression of an adrenomedullin receptor reflect human acute angle-closure glaucoma. ( 17608625 )
2008
18
The association of membrane frizzled-related protein (MFRP) gene with acute angle-closure glaucoma--a pilot study. ( 18781223 )
2008
19
Nonarteritic anterior ischemic optic neuropathy in a patient with primary acute angle-closure glaucoma. ( 19020646 )
2008
20
Acute angle-closure glaucoma from spontaneous massive hemorrhagic retinal detachment. ( 17460436 )
2007
21
Spontaneous, late, in-the-bag intraocular lens subluxation in a patient with a previous acute angle-closure glaucoma attack. ( 15313313 )
2004
22
A case of acute angle-closure glaucoma secondary to posterior scleritis in patient with Sturge-Weber syndrome. ( 11853718 )
2002
23
Anterior ischemic optic neuropathy following acute angle-closure glaucoma. ( 11483097 )
2001
24
Primary care diagnosis of acute closed-angle glaucoma. A case report. ( 9460008 )
1997
25
Acute angle-closure glaucoma associated with intranasal cocaine abuse. ( 8794717 )
1996
26
Hypopyon--an unusual sign in acute angle-closure glaucoma. ( 8262710 )
1993
27
Renal hypertension presenting as acute angle closure glaucoma. ( 2043062 )
1991
28
Acute closed angle glaucoma and sunshine. ( 1795149 )
1991
29
Acute closed-angle glaucoma and Nd-YAG laser iridotomy. ( 2393642 )
1990
30
Acute angle-closure glaucoma following botulinum toxin injection for blepharospasm. ( 2354140 )
1990
31
Acute closed-angle glaucoma after arteriovenous fistulas. ( 2913810 )
1989
32
Acute closed-angle glaucoma complicating hemorrhagic choroidal detachment associated with parenteral thrombolytic agents. ( 3195662 )
1988
33
Psychophysiological stress, elevated intraocular pressure, and acute closed-angle glaucoma. ( 3425684 )
1987
34
Hypopyon keratouveitis in acute angle-closure glaucoma. ( 3661656 )
1987
35
Diurnal variation in onset of acute closed angle glaucoma. ( 3084019 )
1986
36
Management of acute closed-angle glaucoma with miotics and timolol. ( 526463 )
1979
37
Acute closed-angle glaucoma: an investigation into the effect of delay in treatment. ( 526462 )
1979
38
Acute closed-angle glaucoma, a complication of blepharoplasty: report of a case. ( 4817143 )
1974
39
Life events and the onset of acute closed-angle glaucoma. ( 5071431 )
1972
40
THE FELLOW EYE: ANALYSIS OF 50 CASES OF ACUTE CLOSED-ANGLE GLAUCOMA. ( 14192687 )
1964
41
SELF-LIMITING ACUTE CLOSED-ANGLE GLAUCOMA WITH SEGMENTAL IRIS SHORTENING. ( 14189725 )
1963
42
The fellow eye in acute closed-angle glaucoma. ( 13413134 )
1957

Variations for Acute Closed-Angle Glaucoma

Expression for Acute Closed-Angle Glaucoma

Search GEO for disease gene expression data for Acute Closed-Angle Glaucoma.

Pathways for Acute Closed-Angle Glaucoma

GO Terms for Acute Closed-Angle Glaucoma

Biological processes related to Acute Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 8.62 CHM MFRP

Molecular functions related to Acute Closed-Angle Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Rab GTPase binding GO:0017137 8.62 CHM OPTN

Sources for Acute Closed-Angle Glaucoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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