MCID: ACT067
MIFTS: 36

Acute Conjunctivitis

Categories: Eye diseases, Immune diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Acute Conjunctivitis

MalaCards integrated aliases for Acute Conjunctivitis:

Name: Acute Conjunctivitis 12 15 72

Classifications:



External Ids:

Disease Ontology 12 DOID:11184
ICD9CM 35 372.03
ICD10 33 H10.02 H10.3
UMLS 72 C0029668 C0155141

Summaries for Acute Conjunctivitis

MalaCards based summary : Acute Conjunctivitis is related to conjunctival folliculosis and acute contagious conjunctivitis, and has symptoms including discharge from eye An important gene associated with Acute Conjunctivitis is PLD3 (Phospholipase D Family Member 3), and among its related pathways/superpathways is Melanin biosynthesis. The drugs Ofloxacin and Levofloxacin have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and colon, and related phenotype is homeostasis/metabolism.

Related Diseases for Acute Conjunctivitis

Diseases in the Conjunctivitis family:

Acute Conjunctivitis Chronic Conjunctivitis
Bacterial Conjunctivitis Rare Conjunctivitis

Diseases related to Acute Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 conjunctival folliculosis 32.1 PLD3 ADCY10
2 acute contagious conjunctivitis 31.6 PIGQ OCA2
3 acute hemorrhagic conjunctivitis 30.3 PSEN2 PLD3
4 shipyard eye 30.2 PSEN2 PLD3
5 inclusion conjunctivitis 29.6 PSEN2 PLD3
6 pseudomembranous conjunctivitis 11.2
7 serous conjunctivitis except viral 11.2
8 conjunctivitis 10.7
9 bacterial conjunctivitis 10.2
10 albinism, oculocutaneous, type ii 10.1 TYRP1 OCA2
11 albinism, oculocutaneous, type iii 10.1 TYRP1 OCA2
12 chlamydia 10.1
13 haemophilus influenzae 10.1
14 albinism 10.1 TYRP1 OCA2
15 conjunctival disease 10.1 PSEN2 PLD3
16 albinism, oculocutaneous, type ib 10.1 TYRP1 OCA2
17 albinism, oculocutaneous, type v 10.1 TYRP1 OCA2
18 albinism, oculocutaneous, type vii 10.0 TYRP1 OCA2
19 albinism, oculocutaneous, type ia 10.0 TYRP1 OCA2
20 otitis media 9.9
21 trachoma 9.9
22 keratoconjunctivitis 9.9
23 albinism, oculocutaneous, type iv 9.9 TYRP1 OCA2
24 ophthalmomyiasis 9.8
25 uveitis 9.8
26 chronic conjunctivitis 9.8
27 herpes simplex 9.8
28 ocular albinism 9.8 TYRP1 OCA2
29 keratitis, hereditary 9.7
30 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.7
31 yemenite deaf-blind hypopigmentation syndrome 9.7
32 intraocular pressure quantitative trait locus 9.7
33 chlamydia pneumonia 9.7
34 adiaspiromycosis 9.7
35 bacterial infectious disease 9.7
36 myiasis 9.7
37 urethritis 9.7
38 pharyngoconjunctival fever 9.7
39 oral candidiasis 9.7
40 pharyngitis 9.7
41 rhinitis 9.7
42 blepharitis 9.7
43 hypereosinophilic syndrome 9.7
44 47,xyy 9.7
45 anterior uveitis 9.7
46 oculocutaneous albinism 9.6 TYRP1 OCA2

Comorbidity relations with Acute Conjunctivitis via Phenotypic Disease Network (PDN): (show all 11)


Acute Cystitis Alzheimer Disease
Bronchitis Decubitus Ulcer
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Hypertension, Essential
Parkinson Disease, Late-Onset Protein-Energy Malnutrition
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Acute Conjunctivitis:



Diseases related to Acute Conjunctivitis

Symptoms & Phenotypes for Acute Conjunctivitis

UMLS symptoms related to Acute Conjunctivitis:


discharge from eye

MGI Mouse Phenotypes related to Acute Conjunctivitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.1 ADCY10 BLVRA OCA2 PLD3 PSEN2 TYRP1

Drugs & Therapeutics for Acute Conjunctivitis

Drugs for Acute Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ofloxacin Approved Phase 4 82419-36-1 4583
2
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
3
Ganciclovir Approved, Investigational Phase 4 82410-32-0 3454
4 Ophthalmic Solutions Phase 4
5 Anti-Infective Agents Phase 4
6 Cytochrome P-450 Enzyme Inhibitors Phase 4
7 Renal Agents Phase 4
8 Anti-Bacterial Agents Phase 4
9 Antibiotics, Antitubercular Phase 4
10 Topoisomerase Inhibitors Phase 4
11 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
12 Anti-Infective Agents, Urinary Phase 4
13 Ganciclovir triphosphate Phase 4
14 Nucleic Acid Synthesis Inhibitors Phase 4
15 Antiviral Agents Phase 4
16
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
17
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
18
Povidone Approved Phase 3 9003-39-8
19
Iodine Approved, Investigational Phase 3 7553-56-2 807
20
Povidone-iodine Approved Phase 3 25655-41-8
21 Hormone Antagonists Phase 3
22 Micronutrients Phase 3
23 Antiemetics Phase 3
24 Gastrointestinal Agents Phase 3
25 HIV Protease Inhibitors Phase 3
26 Pharmaceutical Solutions Phase 3
27 Hormones Phase 3
28 Peripheral Nervous System Agents Phase 3
29
protease inhibitors Phase 3
30 Anti-Inflammatory Agents Phase 3
31 Lubricant Eye Drops Phase 3
32 glucocorticoids Phase 3
33 Anti-Infective Agents, Local Phase 3
34 Nutrients Phase 3
35 Antineoplastic Agents, Hormonal Phase 3
36 Plasma Substitutes Phase 3
37 Trace Elements Phase 3
38 BB 1101 Phase 3
39 Autonomic Agents Phase 3
40 Blood Substitutes Phase 3
41 cadexomer iodine Phase 3
42 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Phase 4 Study on Effectiveness of Topical 0.5% Levofloxacin on Reduction of Preoperative Conjunctival Flora in Patients Scheduled for Intraocular Surgery Completed NCT00491049 Phase 4 0.5% levofloxacin eye drops
2 A Prospective, Double-masked, Placebo Controlled Comparison of Topical 0.15% Ganciclovir Gel (Zirgan®) Versus 0.3% Hypromellose Gel (Genteal Gel®; Placebo) for the Treatment of Adenovirus Conjunctivitis Completed NCT01533480 Phase 4 Zirgan;genteal gel
3 A Randomized, Double-Masked Trial of Topical Dexamethasone 0.1%/Povidone-iodine 0.4% Versus Artificial Tears for Treatment of Viral Conjunctivitis Completed NCT01481519 Phase 3 dexamethasone 0.1%/povidone-iodine 0.4%;Artificial Tears
4 Epidemiological, Prospective, Multicentric, Open Study To Assess The Characteristics And Frequency Of Adenoviral Conjunctivitis As Diagnosed With The Point Of Care AdenoPlus® Test In Patients Suffering From Acute Conjunctivitis Completed NCT02112773
5 Epidemiological, Prospective, Multicentric, Open Study To Assess The Characteristics And Frequency Of Adenoviral Conjunctivitis As Diagnosed With The Point Of Care AdenoPlus® Test In Patients Suffering From Acute Conjunctivitis Completed NCT03055065
6 Epidemiological, Prospective, Multicentric, Open Study To Assess The Characteristics And Frequency Of Adenoviral Conjunctivitis As Diagnosed With The Point Of Care AdenoPlus® Test In Patients Suffering From Acute Conjunctivitis Completed NCT02254330
7 Epidemiological, Prospective, Multicentric, Open Study To Assess The Characteristics And Frequency Of Adenoviral Conjunctivitis As Diagnosed With The Point Of Care AdenoPlus® Test In Patients Suffering From Acute Conjunctivitis Completed NCT02054273
8 Epidemiological, Prospective, Multicentric, Open Study To Assess The Characteristics And Frequency Of Adenoviral Conjunctivitis As Diagnosed With The Point Of Care AdenoPlus® Test In Patients Suffering From Acute Conjunctivitis Completed NCT02054234
9 A Prospective Blinded Multi-center Clinical Trial to Evaluate the Efficacy of the Recently FDA Approved RPS Adeno Detector for Detecting Adenoviral Conjunctivitis Completed NCT00266734
10 Epidemiology of Conjunctivitis in the Emergency Department of a Reference Ophthalmological Hospital in Goiânia Completed NCT03356197
11 A Comparison of the Sensitivity and Specificity of the RPS Adeno Detector IV™ at Detecting the Presence of Adenovirus to Viral Cell Culture. Completed NCT00921895
12 Clinical Feature and Treatment of Microsporidial Keratoconjunctivitis Recruiting NCT03555409

Search NIH Clinical Center for Acute Conjunctivitis

Genetic Tests for Acute Conjunctivitis

Anatomical Context for Acute Conjunctivitis

MalaCards organs/tissues related to Acute Conjunctivitis:

41
Eye, Testes, Colon, Skin, Bone, Kidney, Bone Marrow

Publications for Acute Conjunctivitis

Articles related to Acute Conjunctivitis:

(show top 50) (show all 235)
# Title Authors PMID Year
1
A Philophthalmid Eyefluke from a Human in Japan. 38
31418651 2019
2
Unbiased Pathogen Detection and Host Gene Profiling for Conjunctivitis. 38
30953744 2019
3
Use of Topical Steroids in Conjunctivitis: A Review of the Evidence. 38
31276464 2019
4
An outbreak of epidemic keratoconjunctivitis caused by human adenovirus type 8 in primary school, southwest China. 38
31307413 2019
5
[Detection and Molecular Characterization of Human Adenoviruses from Acute Conjunctivitis Cases]. 38
31414631 2019
6
Interaction with nontypeable Haemophilus influenzae alters progression of Streptococcus pneumoniae serotypes from colonization to upper respiratory tract diseases in children in a site-specific manner. 38
31233130 2019
7
Diagnosing and managing allergic conjunctivitis in childhood: The allergist's perspective. 38
30742722 2019
8
Infantile Acute Conjunctivitis Induced by β-Lactamase-Positive Amoxicillin-Clavulanate-Resistant Strain of Haemophilus influenzae: A Report of Three Cases. 38
30489345 2019
9
[Study on infectious diseases in Guizhou during the Republic of China]. 38
31137156 2019
10
Re: Keen et al.: Treatment of acute conjunctivitis in the United States and evidence of antibiotic overuse: isolated issue or a systematic problem? (Ophthalmology. 2017;124:1096-1098). 38
29935672 2018
11
Seasonal and Temporal Trends in Childhood Conjunctivitis in Burkina Faso. 38
29761759 2018
12
Analysis of the drug therapy of gatifloxacin and levofloxacin in the treatment of acute bacterial conjunctivitis. 38
30203775 2018
13
ADenoVirus Initiative Study in Epidemiology (ADVISE): Results of a multicentric epidemiology study in Spain. 38
28890236 2018
14
Adenovirus-associated acute conjunctivitis in Beijing, China, 2011-2013. 38
29558885 2018
15
Molecular epidemiology of circulating human adenovirus types in acute conjunctivitis cases in Chandigarh, North India. 38
29735838 2018
16
The use of povidone-iodine in ophthalmology. 38
28984794 2018
17
In Vitro Anti-Inflammatory Activity of Ilex cornuta Extract Mediated by Inhibition of Extracellular Signal-Regulated Kinase Phosphorylation. 38
28854336 2017
18
Antibiotic Prescription Fills for Acute Conjunctivitis among Enrollees in a Large United States Managed Care Network. 38
28624168 2017
19
Treatment of Acute Conjunctivitis in the United States and Evidence of Antibiotic Overuse: Isolated Issue or a Systematic Problem? 38
28734327 2017
20
Molecular identification of viral agents associated with acute conjunctivitis: a prospective controlled study. 38
28535396 2017
21
The Impact of Indonesian Forest Fires on Singaporean Pollution and Health. 38
29558063 2017
22
Epidemiology of bacterial conjunctivitis in chinchillas (Chinchilla lanigera): 49 cases (2005 to 2015). 38
28276116 2017
23
Adult bacterial conjunctivitis: resistance patterns over 12 years in patients attending a large primary eye care centre in the UK. 38
29354693 2017
24
Attack rate and household secondary attack rate of acute conjunctivitis during an outbreak in South India: A community-based survey. 38
27221677 2016
25
Acute conjunctivitis and corneal foreign bodies secondary to tarantula hairs. 38
26283718 2016
26
Correlation between acute conjunctivitis and Asian dust on ocular surfaces. 38
27142484 2016
27
[Acute conjunctivitis caused by respiratory Syncytial virus A group]. 38
25764947 2015
28
Altered hyaluronic acid content in tear fluid of patients with adenoviral conjunctivitis. 38
25714075 2015
29
Clinical and public health management of conjunctivitis in the Israel Defense Forces. 38
28265427 2015
30
Symptoms and treatment of acute conjunctivitis caused by skin secretions of veined tree frog (Trachycephalus venulosus). 38
25443753 2014
31
Genetic characteristics of Haemophilus influenzae and Streptococcus pneumoniae isolated from children with conjunctivitis-otitis media syndrome. 38
24953451 2014
32
The prevalence of chlamydia trachomatis among patients with acute conjunctivitis in Kasr Alainy ophthalmology clinic. 38
25374648 2014
33
Etiology of acute conjunctivitis due to coxsackievirus A24 variant, human adenovirus, herpes simplex virus, and Chlamydia in Beijing, China. 38
25241684 2014
34
Assessment and management of patients with acute red eye. 38
23914708 2013
35
A single-blinded randomized clinical trial comparing polymyxin B-trimethoprim and moxifloxacin for treatment of acute conjunctivitis in children. 38
23092529 2013
36
[Microbial structure of acute bacterial conjunctivitis]. 38
23567301 2013
37
Azithromycin reduces inflammation in a rat model of acute conjunctivitis. 38
23378729 2013
38
Unilateral acute conjunctivitis due to Oestrus ovis in a veterinary doctor. 38
23633869 2013
39
Acute conjunctivitis in primary care: antibiotics and placebo associated with small increase in the proportion cured by 7 days compared with no treatment. 38
22511644 2012
40
Population study on chronic and acute conjunctivitis associated with ambient environment in urban and rural areas. 38
22714096 2012
41
Acute conjunctivitis caused by Ewingella americana. 38
22998132 2012
42
[Bacterial conjunctivitis--diagnosis and therapy update]. 38
22592344 2012
43
Comparison of ocular findings in patients with H1N1 influenza infection versus patients receiving influenza vaccine during a pandemic. 38
22572924 2012
44
Acute infective conjunctivitis in primary care: who needs antibiotics? An individual patient data meta-analysis. 38
22152728 2011
45
Acute haemorrhagic conjunctivitis epidemics and outbreaks of Paederus spp. keratoconjunctivitis ('Nairobi red eyes') and dermatitis. 38
21920128 2011
46
Genome variability of human adenovirus type 8 causing epidemic keratoconjunctivitis during 1986-2003 in Japan. 38
22171158 2011
47
Detection of adenoviruses. 38
21116792 2011
48
The utility of routine conjunctival swabs in management of conjunctivitis. 38
21475340 2011
49
External Ophthalmomyiasis due to Oestrus Ovis: A Case Report from Oman. 38
28845217 2010
50
Understanding of acute hemorrhagic conjunctivitis (AHC) epidemics and outbreaks of Paederus spp keratoconjuctivitis, periorbital oedema ("Nairobi red eyes") and dermatitis. 38
21516962 2010

Variations for Acute Conjunctivitis

Expression for Acute Conjunctivitis

Search GEO for disease gene expression data for Acute Conjunctivitis.

Pathways for Acute Conjunctivitis

Pathways related to Acute Conjunctivitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.32 TYRP1 OCA2

GO Terms for Acute Conjunctivitis

Cellular components related to Acute Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.63 TYRP1 PSEN2 PLD3 PIGQ OCA2 ADCY10
2 endoplasmic reticulum membrane GO:0005789 9.26 PSEN2 PLD3 PIGQ OCA2
3 melanosome membrane GO:0033162 8.62 TYRP1 OCA2

Biological processes related to Acute Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pigmentation GO:0043473 9.16 TYRP1 OCA2
2 melanocyte differentiation GO:0030318 8.96 TYRP1 OCA2
3 melanin biosynthetic process GO:0042438 8.62 TYRP1 OCA2

Sources for Acute Conjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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