MCID: ACT067
MIFTS: 40

Acute Conjunctivitis

Categories: Eye diseases, Immune diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Acute Conjunctivitis

MalaCards integrated aliases for Acute Conjunctivitis:

Name: Acute Conjunctivitis 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:11184
ICD9CM 34 372.03
ICD10 32 H10.02 H10.3
UMLS 71 C0029668 C0155141

Summaries for Acute Conjunctivitis

MalaCards based summary : Acute Conjunctivitis is related to conjunctival folliculosis and pseudomembranous conjunctivitis, and has symptoms including discharge from eye An important gene associated with Acute Conjunctivitis is OCA2 (OCA2 Melanosomal Transmembrane Protein), and among its related pathways/superpathways are A-beta Pathways: Plaque Formation and APP Metabolism and Melanin biosynthesis. The drugs Levofloxacin and Ofloxacin have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and bone, and related phenotypes are homeostasis/metabolism and hearing/vestibular/ear

Related Diseases for Acute Conjunctivitis

Diseases in the Conjunctivitis family:

Acute Conjunctivitis Chronic Conjunctivitis
Bacterial Conjunctivitis Rare Conjunctivitis

Diseases related to Acute Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 conjunctival folliculosis 32.8 PSEN2 PLD3
2 pseudomembranous conjunctivitis 31.8 PLG A2ML1
3 acute hemorrhagic conjunctivitis 30.4 PSEN2 PLD3
4 shipyard eye 30.1 PSEN2 PLD3
5 pharyngoconjunctival fever 30.0 PSEN2 PLD3
6 acute contagious conjunctivitis 26.8 WDR60 TYRP1 TYR SPSB2 SLC45A2 RPH3AL
7 serous conjunctivitis except viral 11.2
8 conjunctivitis 10.7
9 ochronosis 10.2 TYRP1 TYR
10 bacterial conjunctivitis 10.2
11 chlamydia 10.1
12 dowling-degos disease 1 10.1 TYRP1 TYR
13 haemophilus influenzae 10.1
14 kidney cortex necrosis 10.1 TYR PLG
15 congenital nystagmus 10.1 TYR OCA2
16 albinism, oculocutaneous, type vii 10.0 SLC45A2 OCA2
17 keratoconjunctivitis 10.0
18 otitis media 9.9
19 trachoma 9.9
20 herpes simplex 9.9
21 sagittal sinus thrombosis 9.9 PLG BLVRA
22 amelanotic melanoma 9.9 TYRP1 TYR
23 ophthalmomyiasis 9.8
24 uveitis 9.8
25 chronic conjunctivitis 9.8
26 albinism, oculocutaneous, type v 9.7 TYRP1 TYR SLC45A2 OCA2
27 albinism 9.7 TYRP1 TYR SLC45A2 OCA2
28 albinism, oculocutaneous, type ia 9.7 TYRP1 TYR SLC45A2 OCA2
29 albinism, oculocutaneous, type ib 9.7 TYRP1 TYR SLC45A2 OCA2
30 albinism, oculocutaneous, type iv 9.7 TYRP1 TYR SLC45A2 OCA2
31 albinism, oculocutaneous, type ii 9.7 TYRP1 TYR SLC45A2 OCA2
32 albinism, oculocutaneous, type iii 9.7 TYRP1 TYR SLC45A2 OCA2
33 tietz albinism-deafness syndrome 9.7 TYRP1 TYR SLC45A2 OCA2
34 piebald trait 9.7 TYRP1 TYR SLC45A2 OCA2
35 keratitis, hereditary 9.7
36 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.7
37 yemenite deaf-blind hypopigmentation syndrome 9.7
38 intraocular pressure quantitative trait locus 9.7
39 chlamydia pneumonia 9.7
40 adiaspiromycosis 9.7
41 bacterial infectious disease 9.7
42 myiasis 9.7
43 urethritis 9.7
44 inclusion conjunctivitis 9.7
45 oral candidiasis 9.7
46 pharyngitis 9.7
47 rhinitis 9.7
48 chickenpox 9.7
49 iridocyclitis 9.7
50 blepharitis 9.7

Comorbidity relations with Acute Conjunctivitis via Phenotypic Disease Network (PDN): (show all 11)


Acute Cystitis Alzheimer Disease
Bronchitis Decubitus Ulcer
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Hypertension, Essential
Parkinson Disease, Late-Onset Protein-Energy Malnutrition
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Acute Conjunctivitis:



Diseases related to Acute Conjunctivitis

Symptoms & Phenotypes for Acute Conjunctivitis

UMLS symptoms related to Acute Conjunctivitis:


discharge from eye

MGI Mouse Phenotypes related to Acute Conjunctivitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.03 BLVRA FAM163A OCA2 PIGQ PLD3 PLG
2 hearing/vestibular/ear MP:0005377 9.72 NT5DC2 OCA2 PIGQ TYR TYRP1
3 integument MP:0010771 9.7 OCA2 PIGQ PLG PSEN2 SLC45A2 TYR
4 pigmentation MP:0001186 9.26 OCA2 SLC45A2 TYR TYRP1
5 vision/eye MP:0005391 9.17 OCA2 PIGQ PLG PSEN2 SLC45A2 TYR

Drugs & Therapeutics for Acute Conjunctivitis

Drugs for Acute Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
2
Ofloxacin Approved Phase 4 82419-36-1 4583
3
Ganciclovir Approved, Investigational Phase 4 82410-32-0 3454
4 Anti-Infective Agents Phase 4
5 Ophthalmic Solutions Phase 4
6 Renal Agents Phase 4
7 Cytochrome P-450 Enzyme Inhibitors Phase 4
8 Anti-Bacterial Agents Phase 4
9 Antibiotics, Antitubercular Phase 4
10 Topoisomerase Inhibitors Phase 4
11 Anti-Infective Agents, Urinary Phase 4
12 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
13 Antiviral Agents Phase 4
14 Ganciclovir triphosphate Phase 4
15
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
16
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
17
Iodine Approved, Investigational Phase 3 7553-56-2 807
18
Povidone Approved Phase 3 9003-39-8
19
Povidone-iodine Approved Phase 3 25655-41-8
20 Antiemetics Phase 3
21 Micronutrients Phase 3
22 Trace Elements Phase 3
23 HIV Protease Inhibitors Phase 3
24 Lubricant Eye Drops Phase 3
25 Gastrointestinal Agents Phase 3
26
protease inhibitors Phase 3
27 Plasma Substitutes Phase 3
28 Nutrients Phase 3
29 BB 1101 Phase 3
30 Hormone Antagonists Phase 3
31 Anti-Inflammatory Agents Phase 3
32 Anti-Infective Agents, Local Phase 3
33 Autonomic Agents Phase 3
34 Pharmaceutical Solutions Phase 3
35 Antineoplastic Agents, Hormonal Phase 3
36 Blood Substitutes Phase 3
37 glucocorticoids Phase 3
38 cadexomer iodine Phase 3
39 Hormones Phase 3

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Phase 4 Study on Effectiveness of Topical 0.5% Levofloxacin on Reduction of Preoperative Conjunctival Flora in Patients Scheduled for Intraocular Surgery Completed NCT00491049 Phase 4 0.5% levofloxacin eye drops
2 A Prospective, Double-masked, Placebo Controlled Comparison of Topical 0.15% Ganciclovir Gel (Zirgan®) Versus 0.3% Hypromellose Gel (Genteal Gel®; Placebo) for the Treatment of Adenovirus Conjunctivitis Completed NCT01533480 Phase 4 Zirgan;genteal gel
3 A Randomized, Double-Masked Trial of Topical Dexamethasone 0.1%/Povidone-iodine 0.4% Versus Artificial Tears for Treatment of Viral Conjunctivitis Completed NCT01481519 Phase 3 dexamethasone 0.1%/povidone-iodine 0.4%;Artificial Tears
4 Epidemiological, Prospective, Multicentric, Open Study To Assess The Characteristics And Frequency Of Adenoviral Conjunctivitis As Diagnosed With The Point Of Care AdenoPlus® Test In Patients Suffering From Acute Conjunctivitis Completed NCT03055065
5 Epidemiological, Prospective, Multicentric, Open Study To Assess The Characteristics And Frequency Of Adenoviral Conjunctivitis As Diagnosed With The Point Of Care AdenoPlus® Test In Patients Suffering From Acute Conjunctivitis Completed NCT02054273
6 Epidemiological, Prospective, Multicentric, Open Study To Assess The Characteristics And Frequency Of Adenoviral Conjunctivitis As Diagnosed With The Point Of Care AdenoPlus® Test In Patients Suffering From Acute Conjunctivitis Completed NCT02054234
7 Epidemiological, Prospective, Multicentric, Open Study To Assess The Characteristics And Frequency Of Adenoviral Conjunctivitis As Diagnosed With The Point Of Care AdenoPlus® Test In Patients Suffering From Acute Conjunctivitis Completed NCT02254330
8 Epidemiological, Prospective, Multicentric, Open Study To Assess The Characteristics And Frequency Of Adenoviral Conjunctivitis As Diagnosed With The Point Of Care AdenoPlus® Test In Patients Suffering From Acute Conjunctivitis Completed NCT02112773
9 A Prospective Blinded Multi-center Clinical Trial to Evaluate the Efficacy of the Recently FDA Approved RPS Adeno Detector for Detecting Adenoviral Conjunctivitis Completed NCT00266734
10 Epidemiology of Conjunctivitis in the Emergency Department of a Reference Ophthalmological Hospital in Goiânia Completed NCT03356197
11 A Comparison of the Sensitivity and Specificity of the RPS Adeno Detector IV™ at Detecting the Presence of Adenovirus to Viral Cell Culture. Completed NCT00921895
12 Clinical Feature and Treatment of Microsporidial Keratoconjunctivitis Recruiting NCT03555409

Search NIH Clinical Center for Acute Conjunctivitis

Genetic Tests for Acute Conjunctivitis

Anatomical Context for Acute Conjunctivitis

MalaCards organs/tissues related to Acute Conjunctivitis:

40
Eye, Testes, Bone, Kidney, Colon, Bone Marrow, Skin

Publications for Acute Conjunctivitis

Articles related to Acute Conjunctivitis:

(show top 50) (show all 239)
# Title Authors PMID Year
1
Ocular emergencies presenting to an emergency department in Central Spain from 2013 to 2018. 61
31865769 2019
2
Clinical clues predictive of Stevens-Johnson syndrome as the cause of chronic cicatrising conjunctivitis. 61
31630093 2019
3
Interaction With Nontypeable Haemophilus influenzae Alters Progression of Streptococcus pneumoniae From Colonization to Disease in a Site-Specific Manner. 61
31233130 2019
4
Absolute and relative morbidity burdens attributable to ocular and vision-related conditions, active component, U.S. Armed Forces, 2018. 61
31557046 2019
5
A Philophthalmid Eyefluke from a Human in Japan. 61
31418651 2019
6
Unbiased Pathogen Detection and Host Gene Profiling for Conjunctivitis. 61
30953744 2019
7
Use of Topical Steroids in Conjunctivitis: A Review of the Evidence. 61
31276464 2019
8
An outbreak of epidemic keratoconjunctivitis caused by human adenovirus type 8 in primary school, southwest China. 61
31307413 2019
9
[Detection and Molecular Characterization of Human Adenoviruses from Acute Conjunctivitis Cases]. 61
31414631 2019
10
Diagnosing and managing allergic conjunctivitis in childhood: The allergist's perspective. 61
30742722 2019
11
Infantile Acute Conjunctivitis Induced by β-Lactamase-Positive Amoxicillin-Clavulanate-Resistant Strain of Haemophilus influenzae: A Report of Three Cases. 61
30489345 2019
12
[Study on infectious diseases in Guizhou during the Republic of China]. 61
31137156 2019
13
Epidemiology and molecular diagnosis of acute conjunctivitis in patients attending Hamadan, west Iran ophthalmology clinics 2016-2017. 61
31686938 2019
14
Re: Keen et al.: Treatment of acute conjunctivitis in the United States and evidence of antibiotic overuse: isolated issue or a systematic problem? (Ophthalmology. 2017;124:1096-1098). 61
29935672 2018
15
Analysis of the drug therapy of gatifloxacin and levofloxacin in the treatment of acute bacterial conjunctivitis. 61
30203775 2018
16
Seasonal and Temporal Trends in Childhood Conjunctivitis in Burkina Faso. 61
29761759 2018
17
ADenoVirus Initiative Study in Epidemiology (ADVISE): Results of a multicentric epidemiology study in Spain. 61
28890236 2018
18
Adenovirus-associated acute conjunctivitis in Beijing, China, 2011-2013. 61
29558885 2018
19
Molecular epidemiology of circulating human adenovirus types in acute conjunctivitis cases in Chandigarh, North India. 61
29735838 2018
20
The use of povidone-iodine in ophthalmology. 61
28984794 2018
21
In Vitro Anti-Inflammatory Activity of Ilex cornuta Extract Mediated by Inhibition of Extracellular Signal-Regulated Kinase Phosphorylation. 61
28854336 2017
22
Antibiotic Prescription Fills for Acute Conjunctivitis among Enrollees in a Large United States Managed Care Network. 61
28624168 2017
23
Treatment of Acute Conjunctivitis in the United States and Evidence of Antibiotic Overuse: Isolated Issue or a Systematic Problem? 61
28734327 2017
24
Molecular identification of viral agents associated with acute conjunctivitis: a prospective controlled study. 61
28535396 2017
25
The Impact of Indonesian Forest Fires on Singaporean Pollution and Health. 61
29558063 2017
26
Epidemiology of bacterial conjunctivitis in chinchillas (Chinchilla lanigera): 49 cases (2005 to 2015). 61
28276116 2017
27
Adult bacterial conjunctivitis: resistance patterns over 12 years in patients attending a large primary eye care centre in the UK. 61
29354693 2017
28
Attack rate and household secondary attack rate of acute conjunctivitis during an outbreak in South India: A community-based survey. 61
27221677 2016
29
Acute conjunctivitis and corneal foreign bodies secondary to tarantula hairs. 61
26283718 2016
30
Correlation between acute conjunctivitis and Asian dust on ocular surfaces. 61
27142484 2016
31
[Acute conjunctivitis caused by respiratory Syncytial virus A group]. 61
25764947 2015
32
Altered hyaluronic acid content in tear fluid of patients with adenoviral conjunctivitis. 61
25714075 2015
33
Clinical and public health management of conjunctivitis in the Israel Defense Forces. 61
28265427 2015
34
Symptoms and treatment of acute conjunctivitis caused by skin secretions of veined tree frog (Trachycephalus venulosus). 61
25443753 2014
35
Genetic characteristics of Haemophilus influenzae and Streptococcus pneumoniae isolated from children with conjunctivitis-otitis media syndrome. 61
24953451 2014
36
The prevalence of chlamydia trachomatis among patients with acute conjunctivitis in Kasr Alainy ophthalmology clinic. 61
25374648 2014
37
Etiology of acute conjunctivitis due to coxsackievirus A24 variant, human adenovirus, herpes simplex virus, and Chlamydia in Beijing, China. 61
25241684 2014
38
Assessment and management of patients with acute red eye. 61
23914708 2013
39
A single-blinded randomized clinical trial comparing polymyxin B-trimethoprim and moxifloxacin for treatment of acute conjunctivitis in children. 61
23092529 2013
40
[Microbial structure of acute bacterial conjunctivitis]. 61
23567301 2013
41
Azithromycin reduces inflammation in a rat model of acute conjunctivitis. 61
23378729 2013
42
Unilateral acute conjunctivitis due to Oestrus ovis in a veterinary doctor. 61
23633869 2013
43
Acute conjunctivitis in primary care: antibiotics and placebo associated with small increase in the proportion cured by 7 days compared with no treatment. 61
22511644 2012
44
Population study on chronic and acute conjunctivitis associated with ambient environment in urban and rural areas. 61
22714096 2012
45
Acute conjunctivitis caused by Ewingella americana. 61
22998132 2012
46
[Bacterial conjunctivitis--diagnosis and therapy update]. 61
22592344 2012
47
Comparison of ocular findings in patients with H1N1 influenza infection versus patients receiving influenza vaccine during a pandemic. 61
22572924 2012
48
Acute infective conjunctivitis in primary care: who needs antibiotics? An individual patient data meta-analysis. 61
22152728 2011
49
Acute haemorrhagic conjunctivitis epidemics and outbreaks of Paederus spp. keratoconjunctivitis ('Nairobi red eyes') and dermatitis. 61
21920128 2011
50
Detection of adenoviruses. 61
21116792 2011

Variations for Acute Conjunctivitis

Expression for Acute Conjunctivitis

Search GEO for disease gene expression data for Acute Conjunctivitis.

Pathways for Acute Conjunctivitis

Pathways related to Acute Conjunctivitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.32 PSEN2 PLG
2 9.62 TYRP1 TYR SLC45A2 OCA2

GO Terms for Acute Conjunctivitis

Cellular components related to Acute Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 melanosome membrane GO:0033162 8.92 TYRP1 TYR SLC45A2 OCA2

Biological processes related to Acute Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of endopeptidase activity GO:0010951 9.58 CST9L CST9 A2ML1
2 negative regulation of peptidase activity GO:0010466 9.5 CST9L CST9 A2ML1
3 melanocyte differentiation GO:0030318 9.37 TYRP1 OCA2
4 pigmentation GO:0043473 9.33 TYRP1 TYR OCA2
5 developmental pigmentation GO:0048066 9.26 SLC45A2 OCA2
6 eye pigment biosynthetic process GO:0006726 8.96 TYR OCA2
7 melanin biosynthetic process GO:0042438 8.92 TYRP1 TYR SLC45A2 OCA2

Molecular functions related to Acute Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cysteine-type endopeptidase inhibitor activity GO:0004869 9.16 CST9L CST9
2 peptidase inhibitor activity GO:0030414 9.13 CST9L CST9 A2ML1
3 monophenol monooxygenase activity GO:0004503 8.62 TYRP1 TYR

Sources for Acute Conjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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