Aliases & Classifications for Acute Contagious Conjunctivitis

MalaCards integrated aliases for Acute Contagious Conjunctivitis:

Name: Acute Contagious Conjunctivitis 12 15 73
Pink Eye 12 3
Pinkeye 12 43
Keratoconjunctivitis Due to Mycoplasma Conjunctivae 73
Contagious Opthalmia 12
Conjunctivitis 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11213
NCIt 50 C35704

Summaries for Acute Contagious Conjunctivitis

MedlinePlus : 43 Conjunctivitis is the medical name for pink eye. It involves inflammation of the outer layer of the eye and inside of the eyelid. It can cause swelling, itching, burning, discharge, and redness. Causes include Bacterial or viral infection Allergies Substances that cause irritation Contact lens products, eye drops, or eye ointments Pinkeye usually does not affect vision. Infectious pink eye can easily spread from one person to another. The infection will clear in most cases without medical care, but bacterial pinkeye needs treatment with antibiotic eye drops or ointment. NIH: National Eye Institute

MalaCards based summary : Acute Contagious Conjunctivitis, also known as pink eye, is related to conjunctivitis and muckle-wells syndrome, and has symptoms including bloodshot eye, conjunctival congestion and redness of eye. An important gene associated with Acute Contagious Conjunctivitis is OCA2 (OCA2 Melanosomal Transmembrane Protein), and among its related pathways/superpathways are ALK1 signaling events and Follicle Stimulating Hormone (FSH) signaling pathway. The drugs Estradiol and Estradiol valerate have been mentioned in the context of this disorder. Affiliated tissues include eye, and related phenotypes are Decreased human cytomegalovirus (HCMV) strain AD169 replication and Decreased substrate adherent cell growth

CDC : 3 People often call conjunctivitis “pink eye” because it can cause the white of the eye to take on a pink or red color. Symptoms of pink eye can vary but typically include redness or swelling of the white of the eye.

Related Diseases for Acute Contagious Conjunctivitis

Diseases related to Acute Contagious Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 conjunctivitis 11.1
2 muckle-wells syndrome 10.9
3 ewing sarcoma 10.9
4 zika fever 10.9
5 inclusion conjunctivitis 10.8
6 pharyngoconjunctival fever 10.8
7 blepharoconjunctivitis 10.8
8 measles 10.8
9 albinism, oculocutaneous, type ii 10.6 MC1R OCA2
10 acute conjunctivitis 10.5 MC1R OCA2 PIGQ
11 congenital nystagmus 10.3 MC1R OCA2 TYR
12 oculocutaneous albinism 10.3 MC1R OCA2 TYR
13 albinism 10.3 MC1R OCA2 TYR
14 melanocytic nevus syndrome, congenital 10.2 MC1R TYR
15 keratoconjunctivitis 10.1
16 anisocoria 9.8
17 chromosome 18p deletion syndrome 9.5 APPL1 PTER
18 trehalase deficiency 9.5 ACVR1 KCNH1 OCA2 PIGQ TYR
19 endometrial disease 9.2 CYP19A1 TLR4

Graphical network of the top 20 diseases related to Acute Contagious Conjunctivitis:



Diseases related to Acute Contagious Conjunctivitis

Symptoms & Phenotypes for Acute Contagious Conjunctivitis

UMLS symptoms related to Acute Contagious Conjunctivitis:


bloodshot eye, conjunctival congestion, redness of eye, discharge from eye, fever, pruritus

GenomeRNAi Phenotypes related to Acute Contagious Conjunctivitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased human cytomegalovirus (HCMV) strain AD169 replication GR00248-A 9.46 ACVR1 ACVRL1 CKM PRKCG
2 Decreased substrate adherent cell growth GR00193-A-1 9.43 ACVR1 ACVRL1 PRKCG
3 Decreased substrate adherent cell growth GR00193-A-3 9.43 ACVR1
4 Decreased substrate adherent cell growth GR00193-A-4 9.43 ACVR1 ACVRL1
5 Increased cell viability after pRB stimulation GR00230-A-1 8.92 ACVR1 ACVRL1 CKM PRKCG

MGI Mouse Phenotypes related to Acute Contagious Conjunctivitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.07 KCNH1 MC1R ACVR1 OCA2 ACVRL1 PRKCG
2 growth/size/body region MP:0005378 10.02 GPI MC1R ACVR1 OCA2 ACVRL1 APPL1
3 homeostasis/metabolism MP:0005376 9.9 GPI ACVR1 OCA2 ACVRL1 SAA1 APPL1
4 hearing/vestibular/ear MP:0005377 9.73 MC1R OCA2 ACVR1 TLR4 CYP19A1 TYR
5 pigmentation MP:0001186 9.35 MC1R OCA2 TLR4 CYP19A1 TYR
6 renal/urinary system MP:0005367 9.1 FH OCA2 ACVRL1 TLR4 CYP19A1 TYR

Drugs & Therapeutics for Acute Contagious Conjunctivitis

Drugs for Acute Contagious Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3 50-28-2 5757
2 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 3 979-32-8
3
Ethinyl Estradiol Approved Phase 4,Phase 3 57-63-6 5991
4
Moxifloxacin Approved, Investigational Phase 4,Phase 3 354812-41-2, 151096-09-2 152946
5
Norgestimate Approved, Investigational Phase 4,Phase 3 35189-28-7 6540478
6
Polyestradiol phosphate Approved Phase 4,Phase 3 28014-46-2
7
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
8
Ganciclovir Approved, Investigational Phase 4 82410-32-0 3454
9 Anti-Bacterial Agents Phase 4,Phase 3
10 Anti-Infective Agents Phase 4,Phase 3,Not Applicable
11 Contraceptive Agents Phase 4,Phase 3
12 Contraceptives, Oral Phase 4,Phase 3
13 Contraceptives, Oral, Combined Phase 4,Phase 3
14 Estradiol 17 beta-cypionate Phase 4,Phase 3
15 Estradiol 3-benzoate Phase 4,Phase 3
16 Fluoroquinolones Phase 4,Phase 3
17 Norgestimate, ethinyl estradiol drug combination Phase 4,Phase 3
18 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3
19 Ophthalmic Solutions Phase 4,Phase 3,Phase 2,Not Applicable
20 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Not Applicable
21 Polymyxin B Phase 4
22 Polymyxins Phase 4
23 Topoisomerase Inhibitors Phase 4,Phase 3
24 Antiviral Agents Phase 4
25 Ganciclovir triphosphate Phase 4
26
Azithromycin Approved Phase 3 83905-01-5 55185 447043
27
Tobramycin Approved, Investigational Phase 3 32986-56-4 5496 36294
28
Edetic Acid Approved, Vet_approved Phase 3 60-00-4, 62-33-9 6049
29
Mannitol Approved, Investigational Phase 3 69-65-8 453 6251
30
Pentetic acid Approved Phase 3 67-43-6
31
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
32 Tetrahydrozoline Phase 3,Not Applicable
33 Anti-Infective Agents, Local Phase 3,Not Applicable
34 Benzalkonium Compounds Phase 3
35 Calcium polycarbophil Phase 3
36 Citrate Nutraceutical Phase 3
37 Psyllium Nutraceutical Phase 3
38
Iodine Approved, Investigational Not Applicable 7553-56-2 807
39
Povidone Approved Not Applicable 9003-39-8
40
Povidone-iodine Approved Not Applicable 25655-41-8
41 cadexomer iodine Not Applicable
42 Lubricant Eye Drops Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Moxifloxacin vs. Polytrim for Conjunctivitis Completed NCT00581542 Phase 4 moxifloxacin;polytrim
2 A Placebo Controlled Comparison of Topical Zirgan Versus Genteal Gel for the Treatment of Adenovirus Conjunctivitis Completed NCT01533480 Phase 4 Zirgan;genteal gel
3 Moxifloxacin AF Ophthalmic Solution for Treatment of Bacterial Conjunctivitis Completed NCT00759148 Phase 3 Moxifloxacin Alternative Formulation (AF) Ophthalmic Solution 0.5%
4 Evaluation of Clinical and Microbial Efficacy and Safety of AzaSite Compared to Tobramycin for Bacterial Conjunctivitis (C-01-401-004) Completed NCT00105469 Phase 3 AzaSite;Tobramycin
5 Evaluation of Clinical and Microbial Efficacy and Safety of AzaSite Compared to Vehicle for Bacterial Conjunctivitis (C-01-401-003) Completed NCT00105534 Phase 3 AzaSite
6 Efficacy and Safety of Auriclosene (NVC-422) in the Treatment of Bacterial Conjunctivitis Completed NCT01877694 Phase 2 Auriclosene Solution 0.3%;Auriclosene Vehicle
7 Efficacy and Safety of NVC-422 in the Treatment of Adenoviral Conjunctivitis Completed NCT01532336 Phase 2 NVC-422 Solution, 0.3%;NVC-422 Vehicle Solution
8 An Evaluation of the Efficacy and Safety of AL-46383A Ophthalmic Solution for the Treatment of Adenoviral Conjunctivitis Terminated NCT00901693 Phase 2 AL-46383A Ophthalmic Solution;AL-46383A Ophthalmic Solution Vehicle
9 A Comparison of the RPS Adeno Detector IV to Viral Cell Culture at Detecting Adenoviral Conjunctivitis Completed NCT00921895 Not Applicable
10 Reducing Adenoviral Patient Infected Days Recruiting NCT02472223 Not Applicable Betadine 5%;Artificial Tears

Search NIH Clinical Center for Acute Contagious Conjunctivitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Acute Contagious Conjunctivitis

Anatomical Context for Acute Contagious Conjunctivitis

MalaCards organs/tissues related to Acute Contagious Conjunctivitis:

41
Eye

Publications for Acute Contagious Conjunctivitis

Articles related to Acute Contagious Conjunctivitis:

# Title Authors Year
1
Anisocoria Secondary to Anticholinergic Mydriasis from Homeopathic Similasan Pink-Eye-Relief Drops. ( 29042447 )
2017

Variations for Acute Contagious Conjunctivitis

Expression for Acute Contagious Conjunctivitis

Search GEO for disease gene expression data for Acute Contagious Conjunctivitis.

Pathways for Acute Contagious Conjunctivitis

Pathways related to Acute Contagious Conjunctivitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.59 ACVR1 ACVRL1
2 10.39 APPL1 CYP19A1
3 9.32 OCA2 TYR

GO Terms for Acute Contagious Conjunctivitis

Cellular components related to Acute Contagious Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 melanosome membrane GO:0033162 8.62 OCA2 TYR

Biological processes related to Acute Contagious Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 9.4 ACVR1 ACVRL1
2 endocardial cushion morphogenesis GO:0003203 9.37 ACVR1 ACVRL1
3 signal transduction by protein phosphorylation GO:0023014 9.33 ACVR1 ACVRL1 KCNH1
4 activin receptor signaling pathway GO:0032924 9.32 ACVR1 ACVRL1
5 melanin biosynthetic process GO:0042438 9.26 OCA2 TYR
6 eye pigment biosynthetic process GO:0006726 8.96 OCA2 TYR
7 pigmentation GO:0043473 8.8 MC1R OCA2 TYR

Molecular functions related to Acute Contagious Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta binding GO:0050431 9.37 ACVR1 ACVRL1
2 obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity GO:0004702 9.32 ACVR1 ACVRL1
3 activin binding GO:0048185 9.26 ACVR1 ACVRL1
4 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.16 ACVR1 ACVRL1
5 activin receptor activity, type I GO:0016361 8.96 ACVR1 ACVRL1
6 transforming growth factor beta receptor activity, type I GO:0005025 8.62 ACVR1 ACVRL1

Sources for Acute Contagious Conjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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