MCID: ACT011
MIFTS: 45

Acute Contagious Conjunctivitis

Categories: Eye diseases

Aliases & Classifications for Acute Contagious Conjunctivitis

MalaCards integrated aliases for Acute Contagious Conjunctivitis:

Name: Acute Contagious Conjunctivitis 12 15 73
Pink Eye 12 3
Pinkeye 12 43
Keratoconjunctivitis Due to Mycoplasma Conjunctivae 73
Contagious Opthalmia 12
Conjunctivitis 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11213
NCIt 50 C35704
SNOMED-CT 68 17482009

Summaries for Acute Contagious Conjunctivitis

MedlinePlus : 43 Conjunctivitis is the medical name for pink eye. It involves inflammation of the outer layer of the eye and inside of the eyelid. It can cause swelling, itching, burning, discharge, and redness. Causes include Bacterial or viral infection Allergies Substances that cause irritation Contact lens products, eye drops, or eye ointments Pinkeye usually does not affect vision. Infectious pink eye can easily spread from one person to another. The infection will clear in most cases without medical care, but bacterial pinkeye needs treatment with antibiotic eye drops or ointment. NIH: National Eye Institute

MalaCards based summary : Acute Contagious Conjunctivitis, also known as pink eye, is related to albinism, oculocutaneous, type ii and albinism, oculocutaneous, type iii, and has symptoms including fever, pruritus and bloodshot eye. An important gene associated with Acute Contagious Conjunctivitis is OCA2 (OCA2 Melanosomal Transmembrane Protein), and among its related pathways/superpathways are Cushing syndrome and ALK1 signaling events. The drugs Ethinyl Estradiol and Trimethoprim have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and heart, and related phenotypes are Decreased human cytomegalovirus (HCMV) strain AD169 replication and Decreased substrate adherent cell growth

Disease Ontology : 12 A bacterial acute conjunctivitis that is characterized by highly contagious conjunctival hypermia and mucopurulent discharge and has_material basis in Hemophilius Aegypticus.

CDC : 3 People often call conjunctivitis “pink eye” because it can cause the white of the eye to take on a pink or red color. Symptoms of pink eye can vary but typically include redness or swelling of the white of the eye.

Related Diseases for Acute Contagious Conjunctivitis

Graphical network of the top 20 diseases related to Acute Contagious Conjunctivitis:



Diseases related to Acute Contagious Conjunctivitis

Symptoms & Phenotypes for Acute Contagious Conjunctivitis

UMLS symptoms related to Acute Contagious Conjunctivitis:


fever, pruritus, bloodshot eye, conjunctival congestion, redness of eye, discharge from eye

GenomeRNAi Phenotypes related to Acute Contagious Conjunctivitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased human cytomegalovirus (HCMV) strain AD169 replication GR00248-A 9.46 ACVR1 ACVRL1 CKM PRKCG
2 Decreased substrate adherent cell growth GR00193-A-1 9.43 ACVR1 ACVRL1 PRKCG
3 Decreased substrate adherent cell growth GR00193-A-3 9.43 ACVR1
4 Decreased substrate adherent cell growth GR00193-A-4 9.43 ACVR1 ACVRL1
5 Increased cell viability after pRB stimulation GR00230-A-1 8.92 ACVR1 ACVRL1 CKM PRKCG

MGI Mouse Phenotypes related to Acute Contagious Conjunctivitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.07 ACVR1 ACVRL1 APPL1 CYP19A1 KCNH1 MC1R
2 growth/size/body region MP:0005378 10.02 ACVR1 ACVRL1 APPL1 CKM CYP19A1 GPI
3 homeostasis/metabolism MP:0005376 9.9 ACVR1 ACVRL1 APPL1 CKM CYP19A1 FH
4 hearing/vestibular/ear MP:0005377 9.73 ACVR1 CYP19A1 MC1R OCA2 TLR4 TYR
5 pigmentation MP:0001186 9.35 CYP19A1 MC1R OCA2 TLR4 TYR
6 renal/urinary system MP:0005367 9.1 ACVRL1 CYP19A1 FH OCA2 TLR4 TYR

Drugs & Therapeutics for Acute Contagious Conjunctivitis

Drugs for Acute Contagious Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethinyl Estradiol Approved Phase 4,Phase 3 57-63-6 5991
2
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
3
Moxifloxacin Approved, Investigational Phase 4,Phase 3 354812-41-2, 151096-09-2 152946
4
Polyestradiol phosphate Approved Phase 4,Phase 3 28014-46-2
5
Norgestimate Approved, Investigational Phase 4,Phase 3 35189-28-7 6540478
6
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3 50-28-2 5757
7 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 3 979-32-8
8
Ganciclovir Approved, Investigational Phase 4 82410-32-0 3454
9 Estradiol 3-benzoate Phase 4,Phase 3
10 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3
11 Ophthalmic Solutions Phase 4,Phase 3,Phase 2,Not Applicable
12 Estradiol 17 beta-cypionate Phase 4,Phase 3
13 Fluoroquinolones Phase 4,Phase 3
14 Polymyxin B Phase 4
15 Norgestimate, ethinyl estradiol drug combination Phase 4,Phase 3
16 Anti-Bacterial Agents Phase 4,Phase 3
17 Contraceptives, Oral Phase 4,Phase 3
18 Contraceptives, Oral, Combined Phase 4,Phase 3
19 Polymyxins Phase 4
20 Topoisomerase Inhibitors Phase 4,Phase 3
21 Anti-Infective Agents Phase 4,Phase 3,Not Applicable
22 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Not Applicable
23 Contraceptive Agents Phase 4,Phase 3
24 Antiviral Agents Phase 4
25 Ganciclovir triphosphate Phase 4
26
Tobramycin Approved, Investigational Phase 3 32986-56-4 36294 5496
27
Azithromycin Approved Phase 3 83905-01-5 55185 447043
28
Pentetic acid Approved Phase 3 67-43-6
29
Mannitol Approved, Investigational Phase 3 69-65-8 453 6251
30
Edetic Acid Approved, Vet_approved Phase 3 62-33-9, 60-00-4 6049
31
Calcium polycarbophil Approved Phase 3 126040-58-2
32
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
33 Psyllium Phase 3
34 Citrate Phase 3
35 Benzalkonium Compounds Phase 3
36 Anti-Infective Agents, Local Phase 3,Not Applicable
37
Povidone-iodine Approved Not Applicable 25655-41-8
38
Povidone Approved Not Applicable 9003-39-8
39
Iodine Approved, Investigational Not Applicable 7553-56-2 807
40 Lubricant Eye Drops Not Applicable
41 cadexomer iodine Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Moxifloxacin vs. Polytrim for Conjunctivitis Completed NCT00581542 Phase 4 moxifloxacin;polytrim
2 A Placebo Controlled Comparison of Topical Zirgan Versus Genteal Gel for the Treatment of Adenovirus Conjunctivitis Completed NCT01533480 Phase 4 Zirgan;genteal gel
3 Moxifloxacin AF Ophthalmic Solution for Treatment of Bacterial Conjunctivitis Completed NCT00759148 Phase 3 Moxifloxacin Alternative Formulation (AF) Ophthalmic Solution 0.5%
4 Evaluation of Clinical and Microbial Efficacy and Safety of AzaSite Compared to Tobramycin for Bacterial Conjunctivitis (C-01-401-004) Completed NCT00105469 Phase 3 AzaSite;Tobramycin
5 Evaluation of Clinical and Microbial Efficacy and Safety of AzaSite Compared to Vehicle for Bacterial Conjunctivitis (C-01-401-003) Completed NCT00105534 Phase 3 AzaSite
6 Efficacy and Safety of Auriclosene (NVC-422) in the Treatment of Bacterial Conjunctivitis Completed NCT01877694 Phase 2 Auriclosene Solution 0.3%;Auriclosene Vehicle
7 Efficacy and Safety of NVC-422 in the Treatment of Adenoviral Conjunctivitis Completed NCT01532336 Phase 2 NVC-422 Solution, 0.3%;NVC-422 Vehicle Solution
8 An Evaluation of the Efficacy and Safety of AL-46383A Ophthalmic Solution for the Treatment of Adenoviral Conjunctivitis Terminated NCT00901693 Phase 2 AL-46383A Ophthalmic Solution;AL-46383A Ophthalmic Solution Vehicle
9 A Comparison of the RPS Adeno Detector IV to Viral Cell Culture at Detecting Adenoviral Conjunctivitis Completed NCT00921895 Not Applicable
10 Reducing Adenoviral Patient Infected Days Recruiting NCT02472223 Not Applicable Betadine 5%;Artificial Tears

Search NIH Clinical Center for Acute Contagious Conjunctivitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Acute Contagious Conjunctivitis

Anatomical Context for Acute Contagious Conjunctivitis

MalaCards organs/tissues related to Acute Contagious Conjunctivitis:

41
Eye, Testes, Heart

Publications for Acute Contagious Conjunctivitis

Articles related to Acute Contagious Conjunctivitis:

(show all 20)
# Title Authors Year
1
Tear Film Amphiphilic and Anti-Inflammatory Lipids in Bovine Pink Eye. ( 30469369 )
2018
2
Anisocoria Secondary to Anticholinergic Mydriasis from Homeopathic Similasan Pink-Eye-Relief Drops. ( 29042447 )
2017
3
Effect of "Pink Eye" Label on Parents' Intent to Use Antibiotics and Perceived Contagiousness. ( 26294761 )
2016
4
Pink eye and discharge for 18 months. ( 23914790 )
2013
5
Patient information. Pink eye: what you should know. ( 20112458 )
2010
6
The rat pink-eyed dilution (p) mutation: an identical intragenic deletion in pink-eye dilute-coat strains and several Wistar-derived albino strains. ( 16245028 )
2005
7
Physical and linkage mapping of the porcine pink-eye dilution gene ( OCA2 ). ( 12354157 )
2002
8
A possible cause for the 'pink-eye-like' condition in red deer. ( 16031072 )
1984
9
Pink-eye--a new sex-linked mutant of Culex quinquefasciatus. ( 6585350 )
1983
10
Mycoplasma aetiology of keratoconjunctivitis ("pink-eye") in domestic ruminants. ( 4207039 )
1973
11
Mycoplasma and associated bacteria isolated from ovine pink-eye. ( 4251781 )
1971
12
Cytology of "pink-eye" of sheep, including a reference to trachoma of man, by employing acridine orange and iodine stains, and isolation of Mycoplasma agents from infected sheep eyes. ( 4174125 )
1968
13
Ultrastructural differences between forming eumelanin and pheomelanin as revealed by the pink-eye mutation in the fowl. ( 5719204 )
1968
14
Infectious keratoconjunctivitis (pink eye) in cattle in Orissa. ( 6008082 )
1966
15
ISOLATION OF AN AGENT PRODUCING OVINE INFECTIOUS KERATOCONJUNCTIVITIS (PINK EYE). ( 14299415 )
1965
16
The use of cortisone in the treatment of infectious keratoconjunctivitis (pink-eye) in cattle. ( 13416098 )
1957
17
Test of correlation between the pink-eye gene and susceptibility to induced fibrosarcoma in mice. ( 14792553 )
1951
18
Graft compatibility of the "pink eye" gene in mice. ( 14822967 )
1951
19
Management of pink eye. ( 14824789 )
1951
20
Tumor development in backcross mice segregated with respect to the hairless and the pink-eye genes. ( 14889249 )
1951

Variations for Acute Contagious Conjunctivitis

Expression for Acute Contagious Conjunctivitis

Search GEO for disease gene expression data for Acute Contagious Conjunctivitis.

Pathways for Acute Contagious Conjunctivitis

Pathways related to Acute Contagious Conjunctivitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.66 FH MC1R PRKCG TYR
2
Show member pathways
10.69 ACVR1 ACVRL1
3 10.59 APPL1 CYP19A1
4 9.32 OCA2 TYR

GO Terms for Acute Contagious Conjunctivitis

Cellular components related to Acute Contagious Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 melanosome membrane GO:0033162 8.96 OCA2 TYR
2 activin receptor complex GO:0048179 8.62 ACVR1 ACVRL1

Biological processes related to Acute Contagious Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 9.37 ACVR1 ACVRL1
2 activin receptor signaling pathway GO:0032924 9.32 ACVR1 ACVRL1
3 endocardial cushion morphogenesis GO:0003203 9.26 ACVR1 ACVRL1
4 eye pigment biosynthetic process GO:0006726 9.16 OCA2 TYR
5 pigmentation GO:0043473 9.13 MC1R OCA2 TYR
6 melanin biosynthetic process GO:0042438 8.8 MC1R OCA2 TYR

Molecular functions related to Acute Contagious Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta binding GO:0050431 9.4 ACVR1 ACVRL1
2 transforming growth factor beta-activated receptor activity GO:0005024 9.37 ACVR1 ACVRL1
3 activin binding GO:0048185 9.32 ACVR1 ACVRL1
4 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.26 ACVR1 ACVRL1
5 BMP receptor activity GO:0098821 9.16 ACVR1 ACVRL1
6 transforming growth factor beta receptor activity, type I GO:0005025 8.96 ACVR1 ACVRL1
7 activin receptor activity, type I GO:0016361 8.62 ACVR1 ACVRL1

Sources for Acute Contagious Conjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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