MCID: ACT056
MIFTS: 38

Acute Cor Pulmonale

Categories: Cardiovascular diseases

Aliases & Classifications for Acute Cor Pulmonale

MalaCards integrated aliases for Acute Cor Pulmonale:

Name: Acute Cor Pulmonale 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:8517
ICD9CM 34 415.0
SNOMED-CT 67 155325006
ICD10 32 I26.09
UMLS 71 C0155672

Summaries for Acute Cor Pulmonale

MalaCards based summary : Acute Cor Pulmonale is related to pulmonary embolism and aspiration pneumonitis. An important gene associated with Acute Cor Pulmonale is NPPB (Natriuretic Peptide B), and among its related pathways/superpathways are Folate Metabolism and Formation of Fibrin Clot (Clotting Cascade). The drugs Heparin and Apixaban have been mentioned in the context of this disorder. Affiliated tissues include lung and breast, and related phenotypes are cardiovascular system and immune system

Related Diseases for Acute Cor Pulmonale

Diseases related to Acute Cor Pulmonale via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 298)
# Related Disease Score Top Affiliating Genes
1 pulmonary embolism 30.7 PLAT NPPB F3 F2 CRP
2 aspiration pneumonitis 30.3 F3 CRP
3 thrombophilia due to thrombin defect 30.0 PLAT F3 F2
4 thrombosis 30.0 PLG PLAT F3 F2
5 intracranial thrombosis 29.8 PLG PLAT F3 F2
6 pulmonary valve insufficiency 29.7 REN NPPB CRP
7 pulmonary edema 29.5 REN NPPB F2 CRP
8 respiratory failure 29.5 REN NPPB F3 F2 CRP
9 tricuspid valve insufficiency 29.0 REN NPPB F3 F2 CRP
10 patent foramen ovale 28.9 REN PLG PLAT NPPB F3 F2
11 pulmonary hypertension 28.8 REN PLG PLAT NPPB F3 F2
12 adult respiratory distress syndrome 10.7
13 lujo hemorrhagic fever 10.3 NPPB F3
14 medulloadrenal hyperfunction 10.3 PLG F3
15 cardiogenic shock 10.3 PLAT NPPB
16 basal ganglia cerebrovascular disease 10.3 PLG PLAT
17 anterolateral myocardial infarction 10.3 PLAT NPPB
18 ligneous conjunctivitis 10.3 PLG PLAT
19 leech infestation 10.2 PLG F3
20 basilar artery insufficiency 10.2 PLG PLAT
21 brain stem infarction 10.2 PLG PLAT
22 vertebral artery occlusion 10.2 PLG PLAT
23 plasminogen deficiency, type i 10.2 PLG PLAT
24 conversion disorder 10.2 PLG PLAT
25 hereditary angioedema with normal c1inh 10.2 PLG PLAT
26 cardiac tuberculosis 10.2 NPPB CRP
27 middle cerebral artery infarction 10.2 PLG PLAT
28 schistosoma mansoni infection, susceptibility/ 10.2
29 cardiac arrest 10.2
30 covid-19 10.2
31 schistosomiasis 10.2
32 pneumonia 10.2
33 thrombotic microangiopathy 10.2
34 chronic thromboembolic pulmonary hypertension 10.2 NPPB CRP
35 hydrops of gallbladder 10.2 NPPB CRP
36 anterior spinal artery syndrome 10.2 PLG F2
37 thoracic outlet syndrome 10.2 PLG F2
38 livedoid vasculitis 10.2 PLG F2
39 carotid artery occlusion 10.2 PLG PLAT
40 kidney cortex necrosis 10.2 PLG F2
41 papillary adenofibroma 10.2 F3 F2
42 giant hemangioma 10.2 F3 F2
43 hemopneumothorax 10.2 F3 F2
44 dic in newborn 10.2 F3 F2
45 first-degree atrioventricular block 10.2 NPPB CRP
46 subclavian steal syndrome 10.2 F3 CRP
47 waterhouse-friderichsen syndrome 10.2 F3 F2
48 pulmonary embolism and infarction 10.2 F3 F2
49 gastric hemangioma 10.2 F3 F2
50 hepatic infarction 10.2 F3 F2

Comorbidity relations with Acute Cor Pulmonale via Phenotypic Disease Network (PDN): (show all 11)


Acute Cystitis Anxiety
Bronchitis Chronic Pulmonary Heart Disease
Familial Atrial Fibrillation Heart Disease
Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome Osteoporosis
Postinflammatory Pulmonary Fibrosis Pulmonary Hypertension, Primary, 1
Respiratory Failure

Graphical network of the top 20 diseases related to Acute Cor Pulmonale:



Diseases related to Acute Cor Pulmonale

Symptoms & Phenotypes for Acute Cor Pulmonale

MGI Mouse Phenotypes related to Acute Cor Pulmonale:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 CRP F2 F3 NPR2 PLAT PLG
2 immune system MP:0005387 9.7 CRP F2 F3 NPR2 PLAT PLG
3 muscle MP:0005369 9.35 F2 F3 NPR2 PLAT REN
4 respiratory system MP:0005388 9.02 F2 F3 NPR2 PLAT PLG

Drugs & Therapeutics for Acute Cor Pulmonale

Drugs for Acute Cor Pulmonale (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 4 9005-49-6 772 9812414
2
Apixaban Approved Phase 4 503612-47-3 10182969
3 Antithrombins Phase 4
4 Pharmaceutical Solutions Phase 4
5 Fibrinolytic Agents Phase 4
6 Plasminogen Phase 4
7 Serine Proteinase Inhibitors Phase 4
8 HIV Protease Inhibitors Phase 4
9 Factor Xa Inhibitors Phase 4
10 Tissue Plasminogen Activator Phase 4
11 Calcium, Dietary Phase 4
12 Anticoagulants Phase 4
13 calcium heparin Phase 4
14
protease inhibitors Phase 4
15 Antithrombin III Phase 4
16
Serine Investigational, Nutraceutical Phase 4 56-45-1 5951
17
Calcium Nutraceutical Phase 4 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Standard-dose Apixaban AFtEr Very Low-dose ThromboLYSis for Acute Intermediate-high Risk Acute Pulmonary Embolism Suspended NCT03988842 Phase 4 Alteplase;Unfractionated heparin;Placebo;Apixaban
2 Continuous Aspiration Thrombectomy in High and Intermediate-high Risk Pulmonary Embolism Patients Recruiting NCT04473560

Search NIH Clinical Center for Acute Cor Pulmonale

Genetic Tests for Acute Cor Pulmonale

Anatomical Context for Acute Cor Pulmonale

MalaCards organs/tissues related to Acute Cor Pulmonale:

40
Lung, Breast

Publications for Acute Cor Pulmonale

Articles related to Acute Cor Pulmonale:

(show top 50) (show all 317)
# Title Authors PMID Year
1
Cor pulmonale: the role of traditional and advanced echocardiography in the acute and chronic settings. 61
32860180 2021
2
The clot thickens: role of mechanical thrombectomy in intermediate to high-risk pulmonary embolism in the peri-operative setting-a case report. 61
33569531 2021
3
Almitrine Infusion in Severe Acute Respiratory Syndrome Coronavirus 2-Induced Acute Respiratory Distress Syndrome: A Single-Center Observational Study. 61
33093279 2021
4
Usefulness of Right Ventricular Longitudinal Shortening Fraction to Detect Right Ventricular Dysfunction in Acute Cor Pulmonale Related to COVID-19. 61
33558133 2021
5
Effects of Thrombolytic Therapy in Low-Risk Patients With Pulmonary Embolism. 61
32991851 2021
6
Severe COVID-19 with acute respiratory distress syndrome (ARDS) in a sickle cell disease adult patient: case report. 61
33514354 2021
7
Recombinant tissue plasminogen activator treatment for COVID-19 associated ARDS and acute cor pulmonale. 61
33352323 2021
8
Trend of in-hospital deaths by pulmonary embolism in Ecuador. Findings from 2011-2018 national reports. 61
33321283 2020
9
Surviving 2019 novel coronavirus pneumonia: A successful critical case report. 61
32861887 2020
10
Early signs of right ventricular systolic and diastolic dysfunction in acute severe respiratory failure: the importance of diastolic restrictive pattern. 61
31762290 2020
11
Catheter-Directed Thrombolysis in Submassive Pulmonary Embolism and Acute Cor Pulmonale. 61
32718549 2020
12
Acute cor pulmonale from saddle pulmonary embolism in a patient with previous COVID-19: should we prolong prophylactic anticoagulation? 61
32544670 2020
13
Death due to Cardiac Arrest in a Young Female With Highly Suspected COVID-19: A Case Report. 61
33005541 2020
14
Acute Cor Pulmonale in COVID-19-Related ARDS: Improvement With Almitrine Infusion. 61
32835274 2020
15
Pulmonary hypertension with adult respiratory distress syndrome: prevalence, clinical impact, and association with central venous pressure. 61
32699608 2020
16
Acute Cor Pulmonale in Critically Ill Patients with Covid-19. 61
32374956 2020
17
[Cor pulmonale]. 61
32088063 2020
18
Aorto-caval fistula - case report. 61
32545976 2020
19
The harm of high-frequency oscillatory ventilation (HFOV) in ARDS is not related to a high baseline risk of acute cor pulmonale or short-term changes in hemodynamics. 61
31664500 2020
20
[A Chinese consensus statement on the clinical application of transesophageal echocardiography for critical care (2019)]. 61
31775449 2019
21
A cross-sectional study of acute cor pulmonale in acute respiratory distress syndrome patients in China. 61
31856056 2019
22
Feasibility and safety of ultra-low tidal volume ventilation without extracorporeal circulation in moderately severe and severe ARDS patients. 61
31549225 2019
23
Pulmonary Dead Space Monitoring: Identifying Subjects With ARDS at Risk of Developing Right Ventricular Dysfunction. 61
31138736 2019
24
Unusual case of intraoperative acute cor pulmonale during spine surgery. 61
30971611 2019
25
A Nonfatal Massive Pulmonary Embolism in a Very Old Patient: The Protective Filter-Effect of the Chiari Network. 61
31008038 2019
26
Acute Cor Pulmonale in Veno-Venous Extracorporeal Membrane Oxygenation: Three Case Reports. 61
29324515 2018
27
Physiology-guided management of hemodynamics in acute respiratory distress syndrome. 61
30370280 2018
28
Paradoxical brain embolism shadowing massive pulmonary embolism. 61
29792264 2018
29
Re-examining Permissive Hypercapnia in ARDS: A Narrative Review. 61
29175086 2018
30
[Recognizing rare cardiac diseases by electrocardiogram]. 61
29619572 2018
31
Acute Respiratory Distress Syndrome: Challenge for Diagnosis and Therapy. 61
29595185 2018
32
Hemodynamic Assessment of Patients With Septic Shock Using Transpulmonary Thermodilution and Critical Care Echocardiography: A Comparative Study. 61
28866112 2018
33
Adverse Heart-Lung Interactions in Ventilator-induced Lung Injury. 61
28795839 2017
34
Frequency and prognostic impact of basic critical care echocardiography abnormalities in patients with acute respiratory distress syndrome. 61
29260440 2017
35
[Experts consensus on the management of the right heart function in critically ill patients]. 61
29202543 2017
36
Intraoperative Pulmonary Embolism: A Case Report Emphasizing the Utility of Electrocardiogram. 61
28767474 2017
37
Pulmonary tumor embolism secondary to soft tissue and bone sarcomas: a case report and literature review. 61
28854949 2017
38
Right heart function during acute respiratory distress syndrome. 61
28828370 2017
39
The Spectrum of Changes in the Right Ventricle in ARDS: Dilatation, Dysfunction, and Acute Cor Pulmonale. 61
28693765 2017
40
Incidence Proportion of Acute Cor Pulmonale in Patients with Acute Respiratory Distress Syndrome Subjected to Lung Protective Ventilation: A Systematic Review and Meta-analysis. 61
28701843 2017
41
Acute cor pulmonale due to pulmonary tumour thrombotic microangiopathy from renal cell carcinoma. 61
28659364 2017
42
Transient right bundle branch block in a patient with acute pulmonary embolism. 61
27817836 2017
43
[Acute cor pulmonale in acute respiratory distress syndrome]. 61
28627352 2017
44
Extracorporeal life support for refractory ventricular tachycardia. 61
28275618 2017
45
Acute cor pulmonale due to pulmonary tumor thrombotic microangiopathy in two patients with breast cancer. 61
26842105 2017
46
Pulmonary Vascular Dysfunction and Cor Pulmonale During Acute Respiratory Distress Syndrome in Sicklers. 61
27206275 2016
47
Rationale and Description of Right Ventricle-Protective Ventilation in ARDS. 61
27484108 2016
48
Syncope and Dyspnea and Pulmonary Embolism. 61
27269586 2016
49
Massive pulmonary embolism with acute cor pulmonale. 61
26984674 2016
50
Guidelines for the Appropriate Use of Bedside General and Cardiac Ultrasonography in the Evaluation of Critically Ill Patients-Part II: Cardiac Ultrasonography. 61
27182849 2016

Variations for Acute Cor Pulmonale

Expression for Acute Cor Pulmonale

Search GEO for disease gene expression data for Acute Cor Pulmonale.

Pathways for Acute Cor Pulmonale

GO Terms for Acute Cor Pulmonale

Cellular components related to Acute Cor Pulmonale according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.56 TSPAN15 PLG PLAT F3
2 extracellular region GO:0005576 9.5 REN PLG PLAT NPPB F3 F2
3 collagen-containing extracellular matrix GO:0062023 9.46 PLG PLAT F3 F2
4 extracellular space GO:0005615 9.17 REN PLG PLAT NPPB F3 F2

Biological processes related to Acute Cor Pulmonale according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.78 REN PLG PLAT F2
2 cellular protein metabolic process GO:0044267 9.67 TSPAN15 PLG F2
3 acute-phase response GO:0006953 9.51 F2 CRP
4 negative regulation of proteolysis GO:0045861 9.46 PLAT F2
5 cGMP-mediated signaling GO:0019934 9.43 NPR2 NPPB
6 regulation of blood pressure GO:0008217 9.43 REN NPR2 NPPB
7 cGMP biosynthetic process GO:0006182 9.4 NPR2 NPPB
8 negative regulation of fibrinolysis GO:0051918 9.37 PLG F2
9 hemostasis GO:0007599 9.33 PLG F3 F2
10 receptor guanylyl cyclase signaling pathway GO:0007168 9.32 NPR2 NPPB
11 blood coagulation GO:0007596 9.26 PLG PLAT F3 F2
12 fibrinolysis GO:0042730 8.8 PLG PLAT F2

Molecular functions related to Acute Cor Pulmonale according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.56 REN PLG PLAT F2
2 serine-type peptidase activity GO:0008236 9.33 PLG PLAT F2
3 serine-type endopeptidase activity GO:0004252 9.26 PLG PLAT F3 F2
4 signaling receptor binding GO:0005102 9.02 REN PLG PLAT NPPB F2

Sources for Acute Cor Pulmonale

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....