MCID: ACT056
MIFTS: 35

Acute Cor Pulmonale

Categories: Cardiovascular diseases

Aliases & Classifications for Acute Cor Pulmonale

MalaCards integrated aliases for Acute Cor Pulmonale:

Name: Acute Cor Pulmonale 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:8517
ICD9CM 36 415.0
SNOMED-CT 69 49584005
ICD10 34 I26.09
UMLS 74 C0155672

Summaries for Acute Cor Pulmonale

MalaCards based summary : Acute Cor Pulmonale is related to pulmonary embolism and acute respiratory distress syndrome. An important gene associated with Acute Cor Pulmonale is NPPB (Natriuretic Peptide B), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Selenium Micronutrient Network. The drugs Levodopa and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include heart, breast and lung, and related phenotype is cellular.

Related Diseases for Acute Cor Pulmonale

Diseases related to Acute Cor Pulmonale via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 pulmonary embolism 31.4 NPPB PLAT SERPINE1 SERPINF2
2 acute respiratory distress syndrome 10.5
3 cardiogenic shock 10.3 NPPB PLAT
4 patent foramen ovale 10.3
5 anterolateral myocardial infarction 10.3 NPPB PLAT
6 ligneous conjunctivitis 10.3 PLAT PLG
7 central retinal artery occlusion 10.3 PLAT PLG
8 intestinal impaction 10.2 PLG SERPINF2
9 alpha-2-plasmin inhibitor deficiency 10.2 PLG SERPINF2
10 giant hemangioma 10.2 PLG SERPINF2
11 occlusion precerebral artery 10.2 PLAT PLG
12 basilar artery occlusion 10.2 PLAT PLG
13 acute poststreptococcal glomerulonephritis 10.2 PLG SERPINF2
14 korean hemorrhagic fever 10.2 PLG SERPINF2
15 intermediate coronary syndrome 10.2 PLAT PLG
16 breast cancer 10.2
17 hepatocellular carcinoma 10.2
18 pneumonia 10.2
19 tricuspid valve insufficiency 10.2 NPPB PDZK1IP1
20 platelet aggregation, spontaneous 10.2 PLAT SERPINF2
21 tricuspid valve disease 10.2 NPPB PDZK1IP1
22 marantic endocarditis 10.2 PLAT SERPINF2
23 pulmonary artery disease 10.2 PLAT PLG
24 mitral valve insufficiency 10.1 NPPB PDZK1IP1
25 tuberculous empyema 10.1 PLG SERPINE1
26 pregnancy adenoma 10.1 PLAT SERPINF2
27 inferior myocardial infarction 10.1 NPPB PLAT PLG
28 blue toe syndrome 10.1 PLG SERPINE1
29 carotid artery dissection 10.1 PLAT PLG
30 fibrinolytic defect 10.1 PLAT SERPINE1
31 dysbaric osteonecrosis 10.1 PLG SERPINE1
32 argentine hemorrhagic fever 10.1 PLAT SERPINE1
33 central serous chorioretinopathy 10.1 PLAT SERPINE1
34 lemierre's syndrome 10.1 PLG SERPINE1
35 carotid artery thrombosis 10.1 PLAT SERPINE1
36 hepatic vascular disease 10.1 PLG SERPINE1
37 renal cell carcinoma, nonpapillary 10.0
38 congestive heart failure 10.0
39 respiratory failure 10.0
40 schistosomiasis 10.0
41 transitional cell carcinoma 10.0
42 rere-related disorders 10.0
43 angina pectoris 10.0 NPPB PLAT SERPINF2
44 intracranial embolism 10.0 PLAT PLG SERPINF2
45 factor xiii deficiency 10.0 SERPINE1 SERPINF2
46 coronary thrombosis 10.0 PLAT SERPINE1
47 shigellosis 10.0 CAMP VCL
48 chronic venous insufficiency 10.0 PLAT SERPINE1
49 venous insufficiency 10.0 PLAT SERPINE1
50 afibrinogenemia, congenital 10.0 PLAT SERPINF2

Comorbidity relations with Acute Cor Pulmonale via Phenotypic Disease Network (PDN): (show all 13)


Acute Cystitis Anxiety
Bronchitis Chronic Myocardial Ischemia
Chronic Pulmonary Heart Disease Familial Atrial Fibrillation
Heart Disease Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome
Ischemic Heart Disease Osteoporosis
Postinflammatory Pulmonary Fibrosis Pulmonary Hypertension, Primary, 1
Respiratory Failure

Graphical network of the top 20 diseases related to Acute Cor Pulmonale:



Diseases related to Acute Cor Pulmonale

Symptoms & Phenotypes for Acute Cor Pulmonale

MGI Mouse Phenotypes related to Acute Cor Pulmonale:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.17 CAMP CAST PIWIL2 PLAT PLG POR

Drugs & Therapeutics for Acute Cor Pulmonale

Drugs for Acute Cor Pulmonale (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levodopa Approved 59-92-7 6047
2
Dopamine Approved 62-31-7, 51-61-6 681
3
Cabergoline Approved 81409-90-7 54746
4 Cardiotonic Agents
5 Sympathomimetics
6 Protective Agents
7 Peripheral Nervous System Agents
8 Neurotransmitter Agents
9 Dopamine agonists
10 Dopamine Agents
11 Autonomic Agents
12 Vasoconstrictor Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Physiological Study of Low-frequency HFO/HFO-TGI and High-frequency HFO Completed NCT02027129 Phase 1
2 Detection of Right Ventricular Dysfunction by 2D Strain During Acute Respiratory Distress Syndrom (ARDS) Unknown status NCT01757522
3 NT-proBNP as a Tool for the Detection of Acute Pulmonary Artery Embolism (APE) Completed NCT01633671
4 The Association Between Dopamine Agonists and Cardiac Valvulopathy, Fibrosis and Other Cardiopulmonary Events Completed NCT01052948
5 Study of Renin-angiotensin System in Mechanically Ventilated Subjects Recruiting NCT03212690 Local standard of care
6 Acute CorPulmonale and ARDS Circulation Protection China Study China (ACPC) Not yet recruiting NCT03827863

Search NIH Clinical Center for Acute Cor Pulmonale

Genetic Tests for Acute Cor Pulmonale

Anatomical Context for Acute Cor Pulmonale

MalaCards organs/tissues related to Acute Cor Pulmonale:

42
Heart, Breast, Lung, Brain, Testes

Publications for Acute Cor Pulmonale

Articles related to Acute Cor Pulmonale:

(show top 50) (show all 75)
# Title Authors Year
1
Unusual case of intraoperative acute cor pulmonale during spine surgery. ( 30971611 )
2019
2
Acute Cor Pulmonale in Veno-Venous Extracorporeal Membrane Oxygenation: Three Case Reports. ( 29324515 )
2018
3
Acute cor pulmonale due to pulmonary tumor thrombotic microangiopathy in two patients with breast cancer. ( 26842105 )
2017
4
Acute cor pulmonale due to pulmonary tumour thrombotic microangiopathy from renal cell carcinoma. ( 28659364 )
2017
5
The Spectrum of Changes in the Right Ventricle in ARDS: Dilatation, Dysfunction, and Acute Cor Pulmonale. ( 28693765 )
2017
6
Incidence Proportion of Acute Cor Pulmonale in Patients with Acute Respiratory Distress Syndrome Subjected to Lung Protective Ventilation: A Systematic Review and Meta-analysis. ( 28701843 )
2017
7
Electrical impedance tomography-guided prone positioning in a patient with acute cor pulmonale associated with severe acute respiratory distress syndrome. ( 26446805 )
2016
8
Acute cor pulmonale during protective ventilation for acute respiratory distress syndrome: prevalence, predictors, and clinical impact. ( 26650055 )
2016
9
Acute cor pulmonale and the acute respiratory distress syndrome. ( 26759013 )
2016
10
Massive pulmonary embolism with acute cor pulmonale. ( 26984674 )
2016
11
Preventing the development of acute cor pulmonale in patients with acute respiratory distress syndrome: the first step. ( 27162796 )
2016
12
Acute cor pulmonale: an unusual presentation of hepatocellular carcinoma. ( 25186945 )
2015
13
Acute cor pulmonale in ARDS: rationale for protecting the right ventricle. ( 25560864 )
2015
14
Acute respiratory distress syndrome (ARDS)-associated acute cor pulmonale and patent foramen ovale: a multicenter noninvasive hemodynamic study. ( 25887151 )
2015
15
Bedside cardiac testing in acute cor pulmonale. ( 24939650 )
2014
16
An unusual cause of acute cor pulmonale--significance of the 'continuous diaphragm sign'. ( 25443610 )
2014
17
Intravenous infusion of hyperosmotic NaCl solution induces acute cor pulmonale in anesthetized rats. ( 23015108 )
2013
18
Acute cor pulmonale and right heat failure complicating ethanol ablative therapy: anesthetic and radiologic considerations and management. ( 23377237 )
2013
19
Prevalence and prognostic value of acute cor pulmonale and patent foramen ovale in ventilated patients with early acute respiratory distress syndrome: a multicenter study. ( 23860806 )
2013
20
Acute cor pulmonale in ARDS. ( 23907498 )
2013
21
The monitoring of acute cor pulmonale is still necessary in "Berlin" ARDS patients. ( 23942861 )
2013
22
Intracardiac breast tumor presenting as acute cor pulmonale. ( 24180453 )
2013
23
Acute cor pulmonale due to lymphocytic interstitial pneumonia in a child with AIDS. ( 22729199 )
2012
24
An autopsy case of acute cor pulmonale and paradoxical systemic embolism due to tumour cell microemboli in a patient with breast cancer. ( 23035163 )
2012
25
A rare cause for acute cor pulmonale. ( 21712949 )
2011
26
Acute cor pulmonale and repeated pulmonary embolism in a patient with a "worm-like" transit thrombus crossing a patent foramen ovale. ( 20202030 )
2010
27
Acute cor pulmonale. ( 19186411 )
2009
28
Fatal acute cor pulmonale due to portopulmonary hypertension in a noncirrhotic patient. ( 18793380 )
2008
29
Right atrial myxoma associated with acute cor pulmonale. Case report. ( 19378547 )
2008
30
[Interest of the brain natriuretic peptide as a marker of acute cor pulmonale in acute respiratory distress syndrome]. ( 16860526 )
2006
31
Acute cor pulmonale due to microscopic tumour embolism as the first manifestation of hepatocellular carcinoma. ( 12169988 )
2002
32
Echo-Doppler demonstration of acute cor pulmonale at the bedside in the medical intensive care unit. ( 12421740 )
2002
33
Acute cor pulmonale in acute respiratory distress syndrome submitted to protective ventilation: incidence, clinical implications, and prognosis. ( 11505125 )
2001
34
Acute cor pulmonale in acute respiratory distress syndrome: a dreaded complication of the past? ( 11505150 )
2001
35
Acute cor pulmonale in massive pulmonary embolism: incidence, echocardiographic pattern, clinical implications and recovery rate. ( 11685341 )
2001
36
Transitional cell carcinoma manifesting as acute cor pulmonale: cause of microscopic tumor embolism. ( 11702817 )
2001
37
Transesophageal echocardiography for the diagnosis of pulmonary embolism with acute cor pulmonale: a comparison with radiological procedures. ( 9660256 )
1998
38
Echocardiographic pattern of acute cor pulmonale. ( 8996019 )
1997
39
Acute cor pulmonale due to tumor cell microemboli. ( 9311058 )
1997
40
Rapidly reversible acute cor pulmonale after intravenous injection of crushed dextromoramide (Palfium) pills. ( 8727446 )
1996
41
Acute cor pulmonale due to tumor emboli. Diagnosis by pulmonary artery catheterization. ( 8384350 )
1993
42
Acute cor pulmonale and death due to massive fat embolism. ( 1550527 )
1992
43
Acute cor pulmonale secondary to metastatic tumor to the heart: a case report and literature review. ( 2096170 )
1990
44
Rapid resolution of acute cor pulmonale with recombinant tissue plasminogen activator. ( 2507233 )
1989
45
Right ventricular function under acute cor pulmonale. ( 2614875 )
1989
46
Case report. Acute cor pulmonale due to massive pulmonary embolism and successful response to thrombolytic therapy. ( 7064997 )
1982
47
Acute cor pulmonale resulting from tumor microembolism. ( 7376655 )
1980
48
Electrocardiographic evidence of transitory acute cor pulmonale in Boeck's sarcoid. ( 202625 )
1978
49
Electrocardiographic reversion of acute cor pulmonale on long-term oxygen therapy. ( 609990 )
1977
50
Acute cor pulmonale in a child with ventriculo-atrial shunt. Prompt recognition and medical-surgical management. A case report. ( 4254853 )
1971

Variations for Acute Cor Pulmonale

Expression for Acute Cor Pulmonale

Search GEO for disease gene expression data for Acute Cor Pulmonale.

Pathways for Acute Cor Pulmonale

GO Terms for Acute Cor Pulmonale

Cellular components related to Acute Cor Pulmonale according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 CAMP NPPB PLAT PLG SERPINE1 SERPINF2
2 extracellular region GO:0005576 9.8 CAMP NPPB PLAT PLG SERPINE1 SERPINF2
3 extracellular exosome GO:0070062 9.7 CAMP PDZK1IP1 PLAT PLG SERPINE1 SERPINF2
4 collagen-containing extracellular matrix GO:0062023 9.26 PLAT PLG SERPINE1 SERPINF2
5 platelet alpha granule lumen GO:0031093 8.8 PLG SERPINE1 SERPINF2

Biological processes related to Acute Cor Pulmonale according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of peptidase activity GO:0010466 9.5 CAST SERPINE1 SERPINF2
2 platelet degranulation GO:0002576 9.46 PLG SERPINE1 SERPINF2 VCL
3 negative regulation of plasminogen activation GO:0010757 9.26 SERPINE1 SERPINF2
4 negative regulation of fibrinolysis GO:0051918 9.13 PLG SERPINE1 SERPINF2
5 fibrinolysis GO:0042730 8.92 PLAT PLG SERPINE1 SERPINF2

Molecular functions related to Acute Cor Pulmonale according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.46 NPPB PLAT PLG SERPINE1
2 endopeptidase inhibitor activity GO:0004866 9.26 CAST SERPINF2
3 peptidase inhibitor activity GO:0030414 9.13 CAST SERPINE1 SERPINF2
4 protease binding GO:0002020 8.8 CAST SERPINE1 SERPINF2

Sources for Acute Cor Pulmonale

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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