Acute Cor Pulmonale disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ACT056 MIFTS: 35	Acute Cor Pulmonale Categories: Cardiovascular diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Acute Cor Pulmonale

MalaCards integrated aliases for Acute Cor Pulmonale:

Name: Acute Cor Pulmonale ¹² ¹⁵ ⁷⁴

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:8517

ICD9CM ³⁶ 415.0

SNOMED-CT ⁶⁹ 49584005

ICD10 ³⁴ I26.09

UMLS ⁷⁴ C0155672

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Summaries for Acute Cor Pulmonale

MalaCards based summary : Acute Cor Pulmonale is related to pulmonary embolism and acute respiratory distress syndrome. An important gene associated with Acute Cor Pulmonale is NPPB (Natriuretic Peptide B), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Selenium Micronutrient Network. The drugs Levodopa and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include heart, breast and lung, and related phenotype is cellular.

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Related Diseases for Acute Cor Pulmonale

Diseases related to Acute Cor Pulmonale via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)

#	Related Disease	Score	Top Affiliating Genes
1	pulmonary embolism	31.4	NPPB PLAT SERPINE1 SERPINF2
2	acute respiratory distress syndrome	10.5
3	cardiogenic shock	10.3	NPPB PLAT
4	patent foramen ovale	10.3
5	anterolateral myocardial infarction	10.3	NPPB PLAT
6	ligneous conjunctivitis	10.3	PLAT PLG
7	central retinal artery occlusion	10.3	PLAT PLG
8	intestinal impaction	10.2	PLG SERPINF2
9	alpha-2-plasmin inhibitor deficiency	10.2	PLG SERPINF2
10	giant hemangioma	10.2	PLG SERPINF2
11	occlusion precerebral artery	10.2	PLAT PLG
12	basilar artery occlusion	10.2	PLAT PLG
13	acute poststreptococcal glomerulonephritis	10.2	PLG SERPINF2
14	korean hemorrhagic fever	10.2	PLG SERPINF2
15	intermediate coronary syndrome	10.2	PLAT PLG
16	breast cancer	10.2
17	hepatocellular carcinoma	10.2
18	pneumonia	10.2
19	tricuspid valve insufficiency	10.2	NPPB PDZK1IP1
20	platelet aggregation, spontaneous	10.2	PLAT SERPINF2
21	tricuspid valve disease	10.2	NPPB PDZK1IP1
22	marantic endocarditis	10.2	PLAT SERPINF2
23	pulmonary artery disease	10.2	PLAT PLG
24	mitral valve insufficiency	10.1	NPPB PDZK1IP1
25	tuberculous empyema	10.1	PLG SERPINE1
26	pregnancy adenoma	10.1	PLAT SERPINF2
27	inferior myocardial infarction	10.1	NPPB PLAT PLG
28	blue toe syndrome	10.1	PLG SERPINE1
29	carotid artery dissection	10.1	PLAT PLG
30	fibrinolytic defect	10.1	PLAT SERPINE1
31	dysbaric osteonecrosis	10.1	PLG SERPINE1
32	argentine hemorrhagic fever	10.1	PLAT SERPINE1
33	central serous chorioretinopathy	10.1	PLAT SERPINE1
34	lemierre's syndrome	10.1	PLG SERPINE1
35	carotid artery thrombosis	10.1	PLAT SERPINE1
36	hepatic vascular disease	10.1	PLG SERPINE1
37	renal cell carcinoma, nonpapillary	10.0
38	congestive heart failure	10.0
39	respiratory failure	10.0
40	schistosomiasis	10.0
41	transitional cell carcinoma	10.0
42	rere-related disorders	10.0
43	angina pectoris	10.0	NPPB PLAT SERPINF2
44	intracranial embolism	10.0	PLAT PLG SERPINF2
45	factor xiii deficiency	10.0	SERPINE1 SERPINF2
46	coronary thrombosis	10.0	PLAT SERPINE1
47	shigellosis	10.0	CAMP VCL
48	chronic venous insufficiency	10.0	PLAT SERPINE1
49	venous insufficiency	10.0	PLAT SERPINE1
50	afibrinogenemia, congenital	10.0	PLAT SERPINF2

Comorbidity relations with Acute Cor Pulmonale via Phenotypic Disease Network (PDN): (show all 13)

Acute Cystitis	Anxiety
Bronchitis	Chronic Myocardial Ischemia
Chronic Pulmonary Heart Disease	Familial Atrial Fibrillation
Heart Disease	Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome
Ischemic Heart Disease	Osteoporosis
Postinflammatory Pulmonary Fibrosis	Pulmonary Hypertension, Primary, 1
Respiratory Failure

Graphical network of the top 20 diseases related to Acute Cor Pulmonale:

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Symptoms & Phenotypes for Acute Cor Pulmonale

MGI Mouse Phenotypes related to Acute Cor Pulmonale:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	9.17	CAMP CAST PIWIL2 PLAT PLG POR

Sources

Drugs & Therapeutics for Acute Cor Pulmonale

Drugs for Acute Cor Pulmonale (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Levodopa

Approved

59-92-7

6047

Synonyms:

(-)-(3,4-Dihydroxyphenyl)alanine

(−)-3-(3,4-dihydroxyphenyl)-L-alanine

(-)-3-(3,4-Dihydroxyphenyl)-L-alanine

(−)-dopa

(-)-Dopa

(2S)-2-amino-3-(3,4-Dihydroxyphenyl)propanoate

(2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid

(2S)-2-amino-3-(3,4-Dihydroxyphenyl)propanoic acid

.Beta.-(3, 4-Dihydroxyphenyl)alanine

.Beta.-(3,4-Dihydroxyphenyl)-L-alanine

1E83F927-C221-46AA-B90A-81B33C5F3868

23734-74-9

25525-15-9

2-Amino-3-(3,4-dihydroxyphenyl)propanoic acid

3 Hydroxy L tyrosine

3-(3,4-Dihydroxypheny

3-(3,4-Dihydroxyphenyl)-L-alanine

3, 4-Dihydroxy-L-phenylalanine

3, 4-Dihydroxyphenylalanine

3,4-dihydroxy-L-phenylalanine

3,4-Dihydroxy-L-phenylalanine

3,4-dihydroxyphenylalanine

3,4-Dihydroxyphenylalanine

3,4-DIHYDROXYPHENYLALANINE

3,4-Dihydroxyphenylalanine (VAN)

3,4-Dihydroxyphenyl-L-alanine

34241-25-3

37830_FLUKA

3-Hydroxy-L-tyrosine

587-45-1

59-92-7

72572-99-7

72573-00-3

88250-23-1

90638-38-3

AC-11686

AC1L1LOR

AC1Q4U7F

b-(3,4-Dihydroxyphenyl)-a-L-alanine

b-(3,4-Dihydroxyphenyl)alanine

b-(3,4-Dihydroxyphenyl)-L-alanine

Bendopa

beta-(3,4-Dihydroxyphenyl)alanine

beta-(3,4-Dihydroxyphenyl)-alpha-alanine

beta-(3,4-Dihydroxyphenyl)-alpha-L-alanine

beta-(3,4-Dihydroxyphenyl)-L-alanine

BIDD:GT0158

Bio-0575

Biodopa

bmse000322

BPBio1_000059

Brocadopa

BSPBio_000053

BSPBio_002354

C00355

C9H11NO4

CAS-59-92-7

CCRIS 3766

Cerepap

CHEBI:15765

CHEMBL1009

CID6047

Cidandopa

component of Sinemet

D 9628

D00059

D0600

D9628

D9628_SIGMA

DAH

DB01235

Deadopa

Dihydroxy-L-phenylalanine

Dihydroxyphenylalanine

DivK1c_000452

Dopa

DOPA

Dopaflex

Dopaidan

Dopal

Dopal-fher

Dopal-Fher

Dopalina

Dopar

Dopar (TN)

Doparkine

Doparl

Dopasol

Dopaston

Dopaston SE

Dopastone

Dopastral

Dopicar

Doprin

EINECS 200-445-2

Eldopal

Eldopar

Eldopatec

EU-0100454

Eurodopa

Helfo DOPA

helfo-Dopa

Helfo-Dopa

HMS1568C15

HMS1922J14

HMS2090O08

HMS2093N04

HMS501G14

HSDB 3348

IDI1_000452

InChI=1/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14

Insulamina

IV Levodopa

KBio1_000452

KBio2_000934

KBio2_003502

KBio2_006070

KBioGR_001177

KBioSS_000934

L 3,4 Dihydroxyphenylalanine

L Dopa

L(-)-Dopa

L-(-)-Dopa

L-(3, 4-Dihydroxyphenyl)-.alpha.-alani

L-(3, 4-Dihydroxyphenyl)alanine

L-(o-Dihydroxyphenyl)alanine

l)-L-alanine

L-.Beta.-(3,4-Dihydroxyphenyl)alanine

L-3-(3,4-Dihydroxyphenyl)alanine

L-3-(3,4-Dihydroxyphenyl)-alanine

L-3,4-dihydroxyphenylalanine

L-3,4-Dihydroxyphenylalanine

L-3-Hydroxytyrosine

L-4-5-Dihydroxyphenylalanine

Laradopa

Larodopa

L-b-(3,4-Dihydroxyphenyl)-a-alanine

L-b-(3,4-Dihydroxyphenyl)alanine

L-beta-(3,4-Dihydroxyphenyl)alanine

L-beta-(3,4-Dihydroxyphenyl)-alpha-alanine

L-Dihydroxyphenylalanine

L-DOPA

L-DOPA, Parcopa, Atamet, Stalevo, Madopar, Prolopa, Dopar, 3,4-Dihydroxyphenylalanine, Levodopa

Ledopa

Levedopa

Levodopa

Levodopa (JP15/USP)

Levodopa (JP15/USP/INN)

Levodopa [USAN:INN:BAN:JAN]

Levodopum

Levodopum [INN-Latin]

Levopa

L-O-Dihydroxyphenylalanine

L-o-Hydroxytyrosine

Lopac0_000454

Lopac-D-9628

LS-255

L-β-(3,4-dihydroxyphenyl)alanine

Maipedopa

medphano Brand OF levodopa

MLS000028514

MolPort-000-856-937

NCGC00015384-01

NCGC00016270-01

NCGC00016270-06

NCGC00093869-04

nchembio.2007.55-comp26

nchembio.89-comp9

NINDS_000452

NSC 118381

NSC118381

Parda

Pardopa

PDSP1_001541

PDSP2_001525

Prestwick_185

Prestwick0_000017

Prestwick1_000017

Prestwick2_000017

Prestwick3_000017

Prodopa

Ro 4-6316

Roberts brand OF levodopa

Roche brand OF levodopa

S1726_Selleck

SDCCGMLS-0066924.P001

SMR000058312

Sobiodopa

SPBio_000391

SPBio_001974

Spectrum_000454

Spectrum2_000496

SPECTRUM2300205

Spectrum4_000539

Spectrum5_001899

Syndopa

UNII-46627O600J

Veldopa

Weldopa

β-(3,4-dihydroxyphenyl)alanine

β-(3,4-dihydroxyphenyl)-L-alanine

Dopamine

Approved

62-31-7, 51-61-6

681

Synonyms:

(3H)-Dopamine

.alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane

.Beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride

1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)

1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride

1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium

153C5321-5FEE-4B0B-8925-F388F0EEEBD1

2-(3,4-dihydroxyphenyl)ethylamine

2-(3,4-Dihydroxyphenyl)ethylamine

2-benzenediol

3,4 Dihydroxyphenethylamine

3,4-dihydroxyphenethylamine

3,4-Dihydroxyphenethylamine

3,4-Dihydroxyphenethylamine hydrochloride

3,4-Dihydroxyphenylethylamine

3-Hydroxtyramine

3-Hydroxytyramine

3-Hydroxytyramine Hydrobromide

3-Hydroxytyramine hydrochloride

4-(2-Aminoethyl)-1,

4-(2-aminoethyl)-1,2-benzenediol

4-(2-Aminoethyl)-1,2-benzenediol

4-(2-Aminoethyl)-1,2-bezenediol

4-(2-Aminoethyl)benzene-1,2-diol

4-(2-aminoethyl)catechol

4-(2-Aminoethyl)catechol

4-(2-aminoethyl)pyrocatechol

4-(2-aminoethyl)-pyrocatechol

4-(2-Aminoethyl)pyrocatechol

4-(2-Aminoethyl)-pyrocatechol

4-(2-Aminoethyl)pyrocatechol hydrochloride

50444-17-2

51-61-6

62-31-7 (HYDROCHLORIDE)

a-(3,4-Dihydroxyphenyl)-b-aminoethane

AC1L19S5

AC1Q54AX

AC1Q54AY

AKOS003790978

alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane

ASL 279

BIDD:ER0506

Biomol-NT_000001

BPBio1_001123

BSPBio_001932

C03758

CHEBI:18243

CHEMBL59

CID681

cMAP_000036

cMAP_000065

D07870

DB00988

Deoxyepinephrine

DivK1c_000780

Dopamin

Dopamina

Dopamina [INN-Spanish]

dopamine

Dopamine

Dopamine (INN)

Dopamine (USAN)(*hydrochloride*)

Dopamine [INN:BAN]

Dopamine hydrochloride

Dopaminum

Dopaminum [INN-Latin]

Dopastat

Dophamine

Dynatra

EINECS 200-110-0

HSDB 3068

Hydrochloride, dopamine

Hydroxytyramin

hydroxytyramine

Hydroxytyramine

IDI1_000780

intropin

Intropin

Intropin [*hydrochloride*]

IP 498

KBio1_000780

KBio2_001492

KBio2_002388

KBio2_002484

KBio2_004060

KBio2_004956

KBio2_005052

KBio2_006628

KBio2_007524

KBio2_007620

KBio3_001152

KBio3_002867

KBio3_002962

KBioGR_001129

KBioGR_002388

KBioGR_002484

KBioSS_001492

KBioSS_002393

KBioSS_002491

KW-3-060

L000232

L-DOPAMINE

LDP

Lopac0_000586

Lopac-H-8502

LS-159

Medopa (TN)

m-Hydroxytyramine hydrochloride

MolPort-001-641-000

NCGC00015519-01

NCGC00015519-08

NCGC00096050-01

NCGC00096050-02

NCGC00096050-03

NCGC00096050-04

NCGC00096050-05

nchembio.105-comp9

nchembio.107-comp4

nchembio.284-comp1

nchembio.78-comp16

nchembio.89-comp3

nchembio705-8

nchembio801-comp8

NINDS_000780

NSC 173182

NSC169105

NSC173182

Oprea1_088821

Oxytyramine

Pyrocatechol, 4-(2-aminoethyl)- (8CI)

Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride

Revimine

Revivan

SPBio_001205

Spectrum_001012

SPECTRUM1505155

Spectrum2_001023

Spectrum3_000406

Spectrum4_000525

Spectrum5_000945

ST048774

STK301601

UNII-VTD58H1Z2X

UPCMLD0ENAT5885989:001

Cabergoline

Approved

81409-90-7

54746

Synonyms:

(8b)-N-[3-(dimethylamino)Propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)-ergoline-8-carboxamide

(8beta)-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)-6-(prop-2-en-1-yl)ergoline-8-carboxamide

(8beta)-N-[3-(dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)-ergoline-8-carboxamide

(8beta)-N-[3-(dimethylamino)Propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)-ergoline-8-carboxamide

(8beta)-N-[3-(dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-prop-2-en-1-ylergoline-8-carboxamide

(8R)-6-allyl-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)ergoline-8-carboxamide

(8R)-6-Allyl-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)ergoline-8-carboxamide

(8β)-N-[3-(dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)-ergoline-8-carboxamide

1-((6-Allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea

1-((6-Allylergolin-8b-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea

1-((6-allylergolin-8β-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea

1-((6-Allylergolin-8β-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea

1-[(6-allylergoline-8beta-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea

1-[(6-Allylergoline-8beta-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea

1-[(6-Allylergoline-8b-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea

1-[(6-allylergoline-8β-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea

1-[(6-Allylergoline-8β-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea

1-ethyl-2-(3'-dimethylaminopropyl)-3-(6'-allylergoline-8'-beta-carbonyl)urea diphosphate

1-Ethyl-2-(3'-dimethylaminopropyl)-3-(6'-allylergoline-8'-beta-carbonyl)urea diphosphate

1-Ethyl-3-(3'-dimethylamionpropyl)-2-(6'-allylergoline-8'b-carbonyl)urea

1-ethyl-3-(3'-dimethylamionpropyl)-2-(6'-allylergoline-8'beta-carbonyl)urea

1-Ethyl-3-(3'-dimethylamionpropyl)-2-(6'-allylergoline-8'beta-carbonyl)urea

1-ethyl-3-(3'-dimethylamionpropyl)-2-(6'-allylergoline-8'β-carbonyl)urea

1-Ethyl-3-(3'-dimethylamionpropyl)-2-(6'-allylergoline-8'β-carbonyl)urea

81409-90-7

85329-89-1 (diphosphate)

AC-14150

AC1L1HO0

AC1Q5OQ0

BIDD:GT0775

BRD-K86882815-001-01-6

BRN 6020775

C08187

C26H37N5O2

Cabaser

Cabaser (TN)

Cabaseril

Cabergolina

Cabergolina [Spanish]

cabergoline

Cabergoline

Cabergoline (JAN/USAN/INN)

Cabergoline [USAN:BAN:INN]

Cabergoline diphosphate

Cabergolinum

Cabergolinum [Latin]

CG-101

CHEBI:3286

CHEMBL1201087

CID54746

D00987

DB00248

Dostinex

Dostinex (TN)

FCE-21336

FT-0081285

Galastop

HMS2090A09

LS-64370

MolPort-003-845-557

Sogilen

UNII-LL60K9J05T

Cardiotonic Agents

Sympathomimetics

Protective Agents

Peripheral Nervous System Agents

Neurotransmitter Agents

Dopamine agonists

Dopamine Agents

Autonomic Agents

Vasoconstrictor Agents

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Physiological Study of Low-frequency HFO/HFO-TGI and High-frequency HFO	Completed	NCT02027129	Phase 1
2	Detection of Right Ventricular Dysfunction by 2D Strain During Acute Respiratory Distress Syndrom (ARDS)	Unknown status	NCT01757522
3	NT-proBNP as a Tool for the Detection of Acute Pulmonary Artery Embolism (APE)	Completed	NCT01633671
4	The Association Between Dopamine Agonists and Cardiac Valvulopathy, Fibrosis and Other Cardiopulmonary Events	Completed	NCT01052948
5	Study of Renin-angiotensin System in Mechanically Ventilated Subjects	Recruiting	NCT03212690		Local standard of care
6	Acute CorPulmonale and ARDS Circulation Protection China Study China (ACPC)	Not yet recruiting	NCT03827863

Search NIH Clinical Center for Acute Cor Pulmonale

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Genetic Tests for Acute Cor Pulmonale

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Anatomical Context for Acute Cor Pulmonale

MalaCards organs/tissues related to Acute Cor Pulmonale:

⁴²

Heart, Breast, Lung, Brain, Testes

Sources

Publications for Acute Cor Pulmonale

Articles related to Acute Cor Pulmonale:

(show top 50) (show all 75)

#	Title	Authors	Year
1	Unusual case of intraoperative acute cor pulmonale during spine surgery. ( 30971611 )	Mohan B...Wander GS	2019
2	Acute Cor Pulmonale in Veno-Venous Extracorporeal Membrane Oxygenation: Three Case Reports. ( 29324515 )	Dong ER...Nurok M	2018
3	Acute cor pulmonale due to pulmonary tumor thrombotic microangiopathy in two patients with breast cancer. ( 26842105 )	Moon SY...Yoon SY	2017
4	Acute cor pulmonale due to pulmonary tumour thrombotic microangiopathy from renal cell carcinoma. ( 28659364 )	Story M...Fortis S	2017
5	The Spectrum of Changes in the Right Ventricle in ARDS: Dilatation, Dysfunction, and Acute Cor Pulmonale. ( 28693765 )	Lazzeri C...Peris A	2017
6	Incidence Proportion of Acute Cor Pulmonale in Patients with Acute Respiratory Distress Syndrome Subjected to Lung Protective Ventilation: A Systematic Review and Meta-analysis. ( 28701843 )	Das SK...Lahkar A	2017
7	Electrical impedance tomography-guided prone positioning in a patient with acute cor pulmonale associated with severe acute respiratory distress syndrome. ( 26446805 )	Kotani T...Ozaki M	2016
8	Acute cor pulmonale during protective ventilation for acute respiratory distress syndrome: prevalence, predictors, and clinical impact. ( 26650055 )	Mekontso Dessap A...Vieillard-Baron A	2016
9	Acute cor pulmonale and the acute respiratory distress syndrome. ( 26759013 )	Gu?rin C...Matthay MA	2016
10	Massive pulmonary embolism with acute cor pulmonale. ( 26984674 )	Nelson AJ...Parvar SL	2016
11	Preventing the development of acute cor pulmonale in patients with acute respiratory distress syndrome: the first step. ( 27162796 )	Biswas A	2016
12	Acute cor pulmonale: an unusual presentation of hepatocellular carcinoma. ( 25186945 )	Bahsi R...Filik L	2015
13	Acute cor pulmonale in ARDS: rationale for protecting the right ventricle. ( 25560864 )	Repess? X...Vieillard-Baron A	2015
14	Acute respiratory distress syndrome (ARDS)-associated acute cor pulmonale and patent foramen ovale: a multicenter noninvasive hemodynamic study. ( 25887151 )	Legras A...ARCO and CRICS network	2015
15	Bedside cardiac testing in acute cor pulmonale. ( 24939650 )	Ali OM...Siddiqui F	2014
16	An unusual cause of acute cor pulmonale--significance of the 'continuous diaphragm sign'. ( 25443610 )	Mohanan S...Pillai V	2014
17	Intravenous infusion of hyperosmotic NaCl solution induces acute cor pulmonale in anesthetized rats. ( 23015108 )	Abe C...Morita H	2013
18	Acute cor pulmonale and right heat failure complicating ethanol ablative therapy: anesthetic and radiologic considerations and management. ( 23377237 )	Naik B...Matsumoto AH	2013
19	Prevalence and prognostic value of acute cor pulmonale and patent foramen ovale in ventilated patients with early acute respiratory distress syndrome: a multicenter study. ( 23860806 )	Lh?ritier G...Vignon P	2013
20	Acute cor pulmonale in ARDS. ( 23907498 )	Vieillard-Baron A...Matthay MA	2013
21	The monitoring of acute cor pulmonale is still necessary in "Berlin" ARDS patients. ( 23942861 )	Chiumello D...Pesenti A	2013
22	Intracardiac breast tumor presenting as acute cor pulmonale. ( 24180453 )	Wilke LD...Petersen WG	2013
23	Acute cor pulmonale due to lymphocytic interstitial pneumonia in a child with AIDS. ( 22729199 )	Moreira-Silva SF...Miranda AE	2012
24	An autopsy case of acute cor pulmonale and paradoxical systemic embolism due to tumour cell microemboli in a patient with breast cancer. ( 23035163 )	Uga S...Hamada M	2012
25	A rare cause for acute cor pulmonale. ( 21712949 )	Rajasekharan C...Ganga V	2011
26	Acute cor pulmonale and repeated pulmonary embolism in a patient with a "worm-like" transit thrombus crossing a patent foramen ovale. ( 20202030 )	Boeken U...Lichtenberg A	2010
27	Acute cor pulmonale. ( 19186411 )	Jardin F...Vieillard-Baron A	2009
28	Fatal acute cor pulmonale due to portopulmonary hypertension in a noncirrhotic patient. ( 18793380 )	Dickel T...Pye M	2008
29	Right atrial myxoma associated with acute cor pulmonale. Case report. ( 19378547 )	Lorentz MN...Soares RR	2008
30	[Interest of the brain natriuretic peptide as a marker of acute cor pulmonale in acute respiratory distress syndrome]. ( 16860526 )	Thierry S...Tenaillon A	2006
31	Acute cor pulmonale due to microscopic tumour embolism as the first manifestation of hepatocellular carcinoma. ( 12169988 )	Guti?rrez-Mac?as A...De Z?rate MM	2002
32	Echo-Doppler demonstration of acute cor pulmonale at the bedside in the medical intensive care unit. ( 12421740 )	Vieillard-Baron A...Jardin F	2002
33	Acute cor pulmonale in acute respiratory distress syndrome submitted to protective ventilation: incidence, clinical implications, and prognosis. ( 11505125 )	Vieillard-Baron A...Jardin F	2001
34	Acute cor pulmonale in acute respiratory distress syndrome: a dreaded complication of the past? ( 11505150 )	Scherrer-Crosbie M...Zapol WM	2001
35	Acute cor pulmonale in massive pulmonary embolism: incidence, echocardiographic pattern, clinical implications and recovery rate. ( 11685341 )	Vieillard-Baron A...Jardin F	2001
36	Transitional cell carcinoma manifesting as acute cor pulmonale: cause of microscopic tumor embolism. ( 11702817 )	Dhillon SS...Schaub CR	2001
37	Transesophageal echocardiography for the diagnosis of pulmonary embolism with acute cor pulmonale: a comparison with radiological procedures. ( 9660256 )	Vieillard-Baron A...Dubourg O	1998
38	Echocardiographic pattern of acute cor pulmonale. ( 8996019 )	Jardin F...Bourdarias JP	1997
39	Acute cor pulmonale due to tumor cell microemboli. ( 9311058 )	Odeh M...Boss JH	1997
40	Rapidly reversible acute cor pulmonale after intravenous injection of crushed dextromoramide (Palfium) pills. ( 8727446 )	Jullien T...Jardin F	1996
41	Acute cor pulmonale due to tumor emboli. Diagnosis by pulmonary artery catheterization. ( 8384350 )	Shapiro JM...Cole RP	1993
42	Acute cor pulmonale and death due to massive fat embolism. ( 1550527 )	Reid CB...Hill DA	1992
43	Acute cor pulmonale secondary to metastatic tumor to the heart: a case report and literature review. ( 2096170 )	Tallon JM...Montoya DR	1990
44	Rapid resolution of acute cor pulmonale with recombinant tissue plasminogen activator. ( 2507233 )	Gore JM...Becker RC	1989
45	Right ventricular function under acute cor pulmonale. ( 2614875 )	Sekioka K...Nakano T	1989
46	Case report. Acute cor pulmonale due to massive pulmonary embolism and successful response to thrombolytic therapy. ( 7064997 )	Vardan S...Smulyan H	1982
47	Acute cor pulmonale resulting from tumor microembolism. ( 7376655 )	Marini JJ...Huseby JS	1980
48	Electrocardiographic evidence of transitory acute cor pulmonale in Boeck's sarcoid. ( 202625 )	Ferrer MI	1978
49	Electrocardiographic reversion of acute cor pulmonale on long-term oxygen therapy. ( 609990 )	Burke GJ	1977
50	Acute cor pulmonale in a child with ventriculo-atrial shunt. Prompt recognition and medical-surgical management. A case report. ( 4254853 )	Maragos GD...Pfundt TR	1971

Sources

Genes for Acute Cor Pulmonale

Genes related to Acute Cor Pulmonale (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NPPB	Natriuretic Peptide B	Protein Coding	22.28	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	POR	Cytochrome P450 Oxidoreductase	Protein Coding	15.17	DISEASES inferred ¹⁵
3	PLG	Plasminogen	Protein Coding	15.05	DISEASES inferred ¹⁵
4	CAST	Calpastatin	Protein Coding	14.67	DISEASES inferred ¹⁵
5	VCL	Vinculin	Protein Coding	14.6	DISEASES inferred ¹⁵
6	PLAT	Plasminogen Activator, Tissue Type	Protein Coding	14.48	DISEASES inferred ¹⁵
7	SERPINF2	Serpin Family F Member 2	Protein Coding	14.27	DISEASES inferred ¹⁵
8	CAMP	Cathelicidin Antimicrobial Peptide	Protein Coding	14.2	DISEASES inferred ¹⁵
9	SERPINE1	Serpin Family E Member 1	Protein Coding	13.26	DISEASES inferred ¹⁵
10	PIWIL2	Piwi Like RNA-Mediated Gene Silencing 2	Protein Coding	5.42	DISEASES inferred ¹⁵
11	PDZK1IP1	PDZK1 Interacting Protein 1	Protein Coding	5.35	DISEASES inferred ¹⁵

Sources

Variations for Acute Cor Pulmonale

Sources

Expression for Acute Cor Pulmonale

Search GEO for disease gene expression data for Acute Cor Pulmonale.

Sources

Pathways for Acute Cor Pulmonale

Pathways related to Acute Cor Pulmonale according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Response to elevated platelet cytosolic Ca2+ ⁶⁷ Show member pathways Disinhibition of SNARE formation ⁶⁷ Hemostasis ⁶⁷ Platelet activation, signaling and aggregation ⁶⁷ Platelet degranulation ⁶⁷	12.88	PLAT PLG SERPINE1 SERPINF2 VCL
2	Selenium Micronutrient Network ¹ Show member pathways Folate Metabolism ¹ Metabolism of ingested MeSeO2H into MeSeH ⁶⁷ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	11.94	PLAT PLG SERPINE1
3	Formation of Fibrin Clot (Clotting Cascade) ⁶⁷ Show member pathways Blood Clotting Cascade ¹ Blood Coagulation Signaling Pathways ⁶⁶ Common Pathway of Fibrin Clot Formation ⁶⁷ Extrinsic Pathway of Fibrin Clot Formation ⁶⁷ Extrinsic Prothrombin Activation Pathway ⁶⁵ Intrinsic Pathway of Fibrin Clot Formation ⁶⁷	11.66	PLAT PLG SERPINE1 SERPINF2
4	Adhesion ⁴	11.59	PLG SERPINE1 VCL
5	Complement and coagulation cascades ¹ ³⁸	11.4	PLAT PLG SERPINE1 SERPINF2
6	Cell adhesion_ECM remodeling ²³	11.22	PLAT PLG SERPINE1
7	Cell adhesion_Plasmin signaling ²³	11.17	PLAT PLG
8	amb2 Integrin signaling ¹	11.14	PLAT PLG
9	A-beta Pathways: Plaque Formation and APP Metabolism ⁶⁶	10.73	PLAT PLG
10	Dissolution of Fibrin Clot ⁶⁷	10.04	PLAT PLG SERPINE1 SERPINF2

Sources

GO Terms for Acute Cor Pulmonale

Cellular components related to Acute Cor Pulmonale according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.8	CAMP NPPB PLAT PLG SERPINE1 SERPINF2
2	extracellular region	GO:0005576	9.8	CAMP NPPB PLAT PLG SERPINE1 SERPINF2
3	extracellular exosome	GO:0070062	9.7	CAMP PDZK1IP1 PLAT PLG SERPINE1 SERPINF2
4	collagen-containing extracellular matrix	GO:0062023	9.26	PLAT PLG SERPINE1 SERPINF2
5	platelet alpha granule lumen	GO:0031093	8.8	PLG SERPINE1 SERPINF2

Biological processes related to Acute Cor Pulmonale according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of peptidase activity	GO:0010466	9.5	CAST SERPINE1 SERPINF2
2	platelet degranulation	GO:0002576	9.46	PLG SERPINE1 SERPINF2 VCL
3	negative regulation of plasminogen activation	GO:0010757	9.26	SERPINE1 SERPINF2
4	negative regulation of fibrinolysis	GO:0051918	9.13	PLG SERPINE1 SERPINF2
5	fibrinolysis	GO:0042730	8.92	PLAT PLG SERPINE1 SERPINF2

Molecular functions related to Acute Cor Pulmonale according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	signaling receptor binding	GO:0005102	9.46	NPPB PLAT PLG SERPINE1
2	endopeptidase inhibitor activity	GO:0004866	9.26	CAST SERPINF2
3	peptidase inhibitor activity	GO:0030414	9.13	CAST SERPINE1 SERPINF2
4	protease binding	GO:0002020	8.8	CAST SERPINE1 SERPINF2

Sources

Sources for Acute Cor Pulmonale

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

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¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia