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MCID: ACT056
MIFTS: 36

Acute Cor Pulmonale

Categories: Cardiovascular diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Acute Cor Pulmonale

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MalaCards integrated aliases for Acute Cor Pulmonale:

Name: Acute Cor Pulmonale 12 15 71

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:8517
ICD9CM 34 415.0
SNOMED-CT 67 49584005
ICD10 32 I26.09
UMLS 71 C0155672
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Summaries for Acute Cor Pulmonale

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MalaCards based summary : Acute Cor Pulmonale is related to pulmonary embolism and thrombophilia due to thrombin defect. An important gene associated with Acute Cor Pulmonale is NPPB (Natriuretic Peptide B), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. The drugs Heparin and Apixaban have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and brain.

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Related Diseases for Acute Cor Pulmonale

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Diseases related to Acute Cor Pulmonale via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 pulmonary embolism 32.0 PLAT NPPB F3
2 thrombophilia due to thrombin defect 30.2 PLAT F3
3 pulmonary valve insufficiency 30.2 WBP2NL PDZK1IP1 NPPB
4 thrombosis 30.1 PLG PLAT F3
5 pulmonary hypertension 30.0 PLG PLAT NPPB F3
6 intracranial thrombosis 29.9 PLG PLAT F3
7 patent foramen ovale 29.6 PLG PLAT PDZK1IP1 NPPB F3
8 tricuspid valve insufficiency 29.6 WBP2NL PDZK1IP1 NPPB F3
9 respiratory failure 10.4
10 pneumonia 10.3
11 cardiogenic shock 10.3 PLAT NPPB
12 anterolateral myocardial infarction 10.3 PLAT NPPB
13 pulmonary valve disease 10.3 PDZK1IP1 NPPB
14 basal ganglia cerebrovascular disease 10.2 PLG PLAT
15 aortic valve insufficiency 10.2 PDZK1IP1 NPPB
16 anterior cerebral artery infarction 10.2 PLG PLAT
17 ligneous conjunctivitis 10.2 PLG PLAT
18 basilar artery occlusion 10.2 PLG PLAT
19 mitral valve insufficiency 10.2 PDZK1IP1 NPPB
20 schistosoma mansoni infection, susceptibility/ 10.2
21 cardiac arrest 10.2
22 pulmonary edema 10.2
23 schistosomiasis 10.2
24 thrombotic microangiopathy 10.2
25 brain stem infarction 10.2 PLG PLAT
26 thoracic outlet syndrome 10.2 PLG PLAT
27 lujo hemorrhagic fever 10.2 NPPB F3
28 conversion disorder 10.2 PLG PLAT
29 basilar artery insufficiency 10.2 PLG PLAT
30 vitreous detachment 10.2 PLG PLAT
31 central retinal artery occlusion 10.2 PLG PLAT
32 middle cerebral artery infarction 10.2 PLG PLAT
33 obstructive hydrocephalus 10.2 PLG PLAT
34 encephalopathy, familial, with neuroserpin inclusion bodies 10.2 PLG PLAT
35 carotid artery occlusion 10.1 PLG PLAT
36 intracranial sinus thrombosis 10.1 PLG F3
37 leech infestation 10.1 PLG F3
38 hemopericardium 10.1 PLG F3
39 sagittal sinus thrombosis 10.1 PLG F3
40 branch retinal artery occlusion 10.1 PLG F3
41 mitral valve disease 10.1 PDZK1IP1 NPPB
42 peripheral vertigo 10.1 PDZK1IP1 F3
43 cerebral arterial disease 10.1 PLG PLAT
44 constrictive pericarditis 10.1 WBP2NL NPPB
45 grange syndrome 10.1 PLAT F3
46 alcohol dependence 10.1
47 progressive familial heart block, type ia 10.1
48 hepatocellular carcinoma 10.1
49 renal cell carcinoma, nonpapillary 10.1
50 osteogenic sarcoma 10.1

Comorbidity relations with Acute Cor Pulmonale via Phenotypic Disease Network (PDN): (show all 11)


Acute Cystitis Anxiety
Bronchitis Chronic Pulmonary Heart Disease
Familial Atrial Fibrillation Heart Disease
Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome Osteoporosis
Postinflammatory Pulmonary Fibrosis Pulmonary Hypertension, Primary, 1
Respiratory Failure

Graphical network of the top 20 diseases related to Acute Cor Pulmonale:



Diseases related to Acute Cor Pulmonale
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Symptoms & Phenotypes for Acute Cor Pulmonale

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Drugs & Therapeutics for Acute Cor Pulmonale

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Drugs for Acute Cor Pulmonale (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
2
Apixaban Approved Phase 4 503612-47-3 10182969
3
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
4 Antithrombins Phase 4
5 HIV Protease Inhibitors Phase 4
6 Fibrinolytic Agents Phase 4
7
protease inhibitors Phase 4
8 Pharmaceutical Solutions Phase 4
9 Plasminogen Phase 4
10 Serine Proteinase Inhibitors Phase 4
11 Anticoagulants Phase 4
12 Tissue Plasminogen Activator Phase 4
13 Calcium, Dietary Phase 4
14 calcium heparin Phase 4
15 Antithrombin III Phase 4
16 Factor Xa Inhibitors Phase 4
17
Serine Investigational, Nutraceutical Phase 4 56-45-1 5951
18
Dopamine Approved Phase 2, Phase 3 51-61-6, 62-31-7 681
19
Pseudoephedrine Approved Phase 2, Phase 3 90-82-4 7028
20
Epinephrine Approved, Vet_approved Phase 2, Phase 3 51-43-4 5816
21
Ephedrine Approved Phase 2, Phase 3 299-42-3 9294
22
Norepinephrine Approved Phase 2, Phase 3 51-41-2 439260
23
tannic acid Approved Phase 2, Phase 3 1401-55-4
24
Oxymetazoline Approved, Investigational Phase 2, Phase 3 1491-59-4 4636
25
Phenylephrine Approved Phase 2, Phase 3 59-42-7 6041
26
Benzocaine Approved, Investigational Phase 2, Phase 3 1994-09-7, 94-09-7 2337
27
Racepinephrine Approved Phase 2, Phase 3 329-65-7 838
28 Respiratory System Agents Phase 2, Phase 3
29 Neurotransmitter Agents Phase 2, Phase 3
30 Sympathomimetics Phase 2, Phase 3
31 Epinephryl borate Phase 2, Phase 3
32 Adrenergic Agonists Phase 2, Phase 3
33 Anesthetics Phase 2, Phase 3
34 Dopamine Agents Phase 2, Phase 3
35 Anti-Asthmatic Agents Phase 2, Phase 3
36 Central Nervous System Stimulants Phase 2, Phase 3
37 Vasoconstrictor Agents Phase 2, Phase 3
38 Adrenergic beta-Agonists Phase 2, Phase 3
39 Nasal Decongestants Phase 2, Phase 3
40 Central Nervous System Depressants Phase 2, Phase 3
41 Protective Agents Phase 2, Phase 3
42 Autonomic Agents Phase 2, Phase 3
43 Bronchodilator Agents Phase 2, Phase 3
44 Mydriatics Phase 2, Phase 3
45 Adrenergic Agents Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Standard-dose Apixaban AFtEr Very Low-dose ThromboLYSis for Acute Intermediate-high Risk Acute Pulmonary Embolism Not yet recruiting NCT03988842 Phase 4 Alteplase;Unfractionated heparin;Placebo;Apixaban
2 Effect of Target Intraoperative Blood Pressure on the Incidence of Post-operative Cognitive Dysfunction in Patients Aged 75 and Older Undergoing General Anesthesia for Non-cardiac Surgery: an International Multicenter Randomized Controlled Trial Suspended NCT02428062 Phase 2, Phase 3 Phenylephrine;Intravenous fluids;Ephedrine;Epinephrine;Norepinephrine;Dopamine
3 NT-proBNP: a Useful Tool for the Detection of Acute Pulmonary Artery Embolism in Post-surgical Patients Completed NCT01633671
4 ImaCor II Effects of Hemodynamic Monitoring Using the ImaCor Single Use Transesophageal Echocardiography Probe in Critically Ill Patients - a Randomized Controlled Trial Completed NCT02048566
5 Hemodynamic Effects of PEEP in Patients With ARDS Recruiting NCT03896802
6 Prone Positioning During High Flow Oxygen Therapy in Patients With Acute Hypoxemic Respiratory Failure: a Pilot Physiological Trial Recruiting NCT03095300

Search NIH Clinical Center for Acute Cor Pulmonale

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Genetic Tests for Acute Cor Pulmonale

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Anatomical Context for Acute Cor Pulmonale

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MalaCards organs/tissues related to Acute Cor Pulmonale:

40
Heart, Lung, Brain, Breast, Liver, Bone, Testes
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Publications for Acute Cor Pulmonale

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Articles related to Acute Cor Pulmonale:

(show top 50) (show all 299)
# Title Authors PMID Year
1
The harm of high-frequency oscillatory ventilation (HFOV) in ARDS is not related to a high baseline risk of acute cor pulmonale or short-term changes in hemodynamics. 61
31664500 2020
2
[A Chinese consensus statement on the clinical application of transesophageal echocardiography for critical care (2019)]. 61
31775449 2019
3
A cross-sectional study of acute cor pulmonale in acute respiratory distress syndrome patients in China. 61
31856056 2019
4
A cross-sectional study of acute cor pulmonale in acute respiratory distress syndrome patients in China. 61
31764188 2019
5
Early signs of right ventricular systolic and diastolic dysfunction in acute severe respiratory failure: the importance of diastolic restrictive pattern. 61
31762290 2019
6
Feasibility and safety of ultra-low tidal volume ventilation without extracorporeal circulation in moderately severe and severe ARDS patients. 61
31549225 2019
7
Pulmonary Dead Space Monitoring: Identifying Subjects With ARDS at Risk of Developing Right Ventricular Dysfunction. 61
31138736 2019
8
Unusual case of intraoperative acute cor pulmonale during spine surgery. 61
30971611 2019
9
A Nonfatal Massive Pulmonary Embolism in a Very Old Patient: The Protective Filter-Effect of the Chiari Network. 61
31008038 2019
10
Acute Cor Pulmonale in Veno-Venous Extracorporeal Membrane Oxygenation: Three Case Reports. 61
29324515 2018
11
Physiology-guided management of hemodynamics in acute respiratory distress syndrome. 61
30370280 2018
12
Paradoxical brain embolism shadowing massive pulmonary embolism. 61
29792264 2018
13
Re-examining Permissive Hypercapnia in ARDS: A Narrative Review. 61
29175086 2018
14
[Recognizing rare cardiac diseases by electrocardiogram]. 61
29619572 2018
15
Acute Respiratory Distress Syndrome: Challenge for Diagnosis and Therapy. 61
29595185 2018
16
Hemodynamic Assessment of Patients With Septic Shock Using Transpulmonary Thermodilution and Critical Care Echocardiography: A Comparative Study. 61
28866112 2018
17
Adverse Heart-Lung Interactions in Ventilator-induced Lung Injury. 61
28795839 2017
18
[Experts consensus on the management of the right heart function in critically ill patients]. 61
29202543 2017
19
Frequency and prognostic impact of basic critical care echocardiography abnormalities in patients with acute respiratory distress syndrome. 61
29260440 2017
20
Intraoperative Pulmonary Embolism: A Case Report Emphasizing the Utility of Electrocardiogram. 61
28767474 2017
21
Pulmonary tumor embolism secondary to soft tissue and bone sarcomas: a case report and literature review. 61
28854949 2017
22
Right heart function during acute respiratory distress syndrome. 61
28828370 2017
23
The Spectrum of Changes in the Right Ventricle in ARDS: Dilatation, Dysfunction, and Acute Cor Pulmonale. 61
28693765 2017
24
Incidence Proportion of Acute Cor Pulmonale in Patients with Acute Respiratory Distress Syndrome Subjected to Lung Protective Ventilation: A Systematic Review and Meta-analysis. 61
28701843 2017
25
Acute cor pulmonale due to pulmonary tumour thrombotic microangiopathy from renal cell carcinoma. 61
28659364 2017
26
Transient right bundle branch block in a patient with acute pulmonary embolism. 61
27817836 2017
27
[Acute cor pulmonale in acute respiratory distress syndrome]. 61
28627352 2017
28
Extracorporeal life support for refractory ventricular tachycardia. 61
28275618 2017
29
Acute cor pulmonale due to pulmonary tumor thrombotic microangiopathy in two patients with breast cancer. 61
26842105 2017
30
Rationale and Description of Right Ventricle-Protective Ventilation in ARDS. 61
27484108 2016
31
Pulmonary Vascular Dysfunction and Cor Pulmonale During Acute Respiratory Distress Syndrome in Sicklers. 61
27206275 2016
32
Syncope and Dyspnea and Pulmonary Embolism. 61
27269586 2016
33
Massive pulmonary embolism with acute cor pulmonale. 61
26984674 2016
34
Assessment of the effects of inspiratory load on right ventricular function. 61
27054626 2016
35
Guidelines for the Appropriate Use of Bedside General and Cardiac Ultrasonography in the Evaluation of Critically Ill Patients-Part II: Cardiac Ultrasonography. 61
27182849 2016
36
Experts' opinion on management of hemodynamics in ARDS patients: focus on the effects of mechanical ventilation. 61
27038480 2016
37
Acute cor pulmonale and the acute respiratory distress syndrome. 61
26759013 2016
38
Acute cor pulmonale during protective ventilation for acute respiratory distress syndrome: prevalence, predictors, and clinical impact. 61
26650055 2016
39
Preventing the development of acute cor pulmonale in patients with acute respiratory distress syndrome: the first step. 61
27162796 2016
40
Focused cardiac and lung ultrasonography: implications and applicability in the perioperative period. 61
28913476 2016
41
Pulmonary vascular dysfunction in refractory acute respiratory distress syndrome before veno-venous extracorporeal membrane oxygenation. 61
26482659 2016
42
The potential role and limitations of echocardiography in acute respiratory distress syndrome. 61
26660667 2016
43
Electrical impedance tomography-guided prone positioning in a patient with acute cor pulmonale associated with severe acute respiratory distress syndrome. 61
26446805 2016
44
Acute respiratory distress syndrome: the heart side of the moon. 61
26627538 2016
45
Hemodynamics of Acute Right Heart Failure in Mechanically Ventilated Patients with Acute Respiratory Distress Syndrome. 61
26567491 2015
46
Fatal foreign-body granulomatous pulmonary embolization due to microcrystalline cellulose in a patient receiving total parenteral nutrition: all crystals are not what they seem. 61
25737334 2015
47
Acute respiratory distress syndrome (ARDS)-associated acute cor pulmonale and patent foramen ovale: a multicenter noninvasive hemodynamic study. 61
25887151 2015
48
Clinical and morphologic features of acute, subacute and chronic cor pulmonale (pulmonary heart disease). 61
25727086 2015
49
Acute cor pulmonale: an unusual presentation of hepatocellular carcinoma. 61
25186945 2015
50
Acute cor pulmonale in ARDS: rationale for protecting the right ventricle. 61
25560864 2015
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Variations for Acute Cor Pulmonale

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Expression for Acute Cor Pulmonale

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Search GEO for disease gene expression data for Acute Cor Pulmonale.
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Pathways for Acute Cor Pulmonale

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Pathways related to Acute Cor Pulmonale according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Formation of Fibrin Clot (Clotting Cascade) 65
Show member pathways
 11.53 PLG PLAT F3
2
Complement and coagulation cascades 1 36
11.29 PLG PLAT F3
3
Cell adhesion_ECM remodeling 22
11.19 PLG PLAT
4
Cell adhesion_Plasmin signaling 22
11.06 PLG PLAT
5
amb2 Integrin signaling 1
11 PLG PLAT
6
A-beta Pathways: Plaque Formation and APP Metabolism 64
10.62 PLG PLAT
7
Dissolution of Fibrin Clot 65
9.74 PLG PLAT
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GO Terms for Acute Cor Pulmonale

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Biological processes related to Acute Cor Pulmonale according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.33 PLG PLAT F3
2 hemostasis GO:0007599 9.26 PLG F3
3 fibrinolysis GO:0042730 8.96 PLG PLAT
4 trans-synaptic signaling by BDNF, modulating synaptic transmission GO:0099183 8.62 PLG PLAT

Molecular functions related to Acute Cor Pulmonale according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 8.8 PLG PLAT F3
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Sources for Acute Cor Pulmonale

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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