Acute Cor Pulmonale disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ACT056 MIFTS: 38	Acute Cor Pulmonale Categories: Cardiovascular diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Acute Cor Pulmonale

MalaCards integrated aliases for Acute Cor Pulmonale:

Name: Acute Cor Pulmonale ¹² ¹⁵ ⁷¹

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:8517

ICD9CM ³⁴ 415.0

SNOMED-CT ⁶⁷ 155325006

ICD10 ³² I26.09

UMLS ⁷¹ C0155672

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Summaries for Acute Cor Pulmonale

MalaCards based summary : Acute Cor Pulmonale is related to pulmonary embolism and aspiration pneumonitis. An important gene associated with Acute Cor Pulmonale is NPPB (Natriuretic Peptide B), and among its related pathways/superpathways are Folate Metabolism and Formation of Fibrin Clot (Clotting Cascade). The drugs Heparin and Apixaban have been mentioned in the context of this disorder. Affiliated tissues include lung and breast, and related phenotypes are cardiovascular system and immune system

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Related Diseases for Acute Cor Pulmonale

Diseases related to Acute Cor Pulmonale via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 298)

#	Related Disease	Score	Top Affiliating Genes
1	pulmonary embolism	30.7	PLAT NPPB F3 F2 CRP
2	aspiration pneumonitis	30.3	F3 CRP
3	thrombophilia due to thrombin defect	30.0	PLAT F3 F2
4	thrombosis	30.0	PLG PLAT F3 F2
5	intracranial thrombosis	29.8	PLG PLAT F3 F2
6	pulmonary valve insufficiency	29.7	REN NPPB CRP
7	pulmonary edema	29.5	REN NPPB F2 CRP
8	respiratory failure	29.5	REN NPPB F3 F2 CRP
9	tricuspid valve insufficiency	29.0	REN NPPB F3 F2 CRP
10	patent foramen ovale	28.9	REN PLG PLAT NPPB F3 F2
11	pulmonary hypertension	28.8	REN PLG PLAT NPPB F3 F2
12	adult respiratory distress syndrome	10.7
13	lujo hemorrhagic fever	10.3	NPPB F3
14	medulloadrenal hyperfunction	10.3	PLG F3
15	cardiogenic shock	10.3	PLAT NPPB
16	basal ganglia cerebrovascular disease	10.3	PLG PLAT
17	anterolateral myocardial infarction	10.3	PLAT NPPB
18	ligneous conjunctivitis	10.3	PLG PLAT
19	leech infestation	10.2	PLG F3
20	basilar artery insufficiency	10.2	PLG PLAT
21	brain stem infarction	10.2	PLG PLAT
22	vertebral artery occlusion	10.2	PLG PLAT
23	plasminogen deficiency, type i	10.2	PLG PLAT
24	conversion disorder	10.2	PLG PLAT
25	hereditary angioedema with normal c1inh	10.2	PLG PLAT
26	cardiac tuberculosis	10.2	NPPB CRP
27	middle cerebral artery infarction	10.2	PLG PLAT
28	schistosoma mansoni infection, susceptibility/	10.2
29	cardiac arrest	10.2
30	covid-19	10.2
31	schistosomiasis	10.2
32	pneumonia	10.2
33	thrombotic microangiopathy	10.2
34	chronic thromboembolic pulmonary hypertension	10.2	NPPB CRP
35	hydrops of gallbladder	10.2	NPPB CRP
36	anterior spinal artery syndrome	10.2	PLG F2
37	thoracic outlet syndrome	10.2	PLG F2
38	livedoid vasculitis	10.2	PLG F2
39	carotid artery occlusion	10.2	PLG PLAT
40	kidney cortex necrosis	10.2	PLG F2
41	papillary adenofibroma	10.2	F3 F2
42	giant hemangioma	10.2	F3 F2
43	hemopneumothorax	10.2	F3 F2
44	dic in newborn	10.2	F3 F2
45	first-degree atrioventricular block	10.2	NPPB CRP
46	subclavian steal syndrome	10.2	F3 CRP
47	waterhouse-friderichsen syndrome	10.2	F3 F2
48	pulmonary embolism and infarction	10.2	F3 F2
49	gastric hemangioma	10.2	F3 F2
50	hepatic infarction	10.2	F3 F2

Comorbidity relations with Acute Cor Pulmonale via Phenotypic Disease Network (PDN): (show all 11)

Acute Cystitis	Anxiety
Bronchitis	Chronic Pulmonary Heart Disease
Familial Atrial Fibrillation	Heart Disease
Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome	Osteoporosis
Postinflammatory Pulmonary Fibrosis	Pulmonary Hypertension, Primary, 1
Respiratory Failure

Graphical network of the top 20 diseases related to Acute Cor Pulmonale:

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Symptoms & Phenotypes for Acute Cor Pulmonale

MGI Mouse Phenotypes related to Acute Cor Pulmonale:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	9.8	CRP F2 F3 NPR2 PLAT PLG
2	immune system	MP:0005387	9.7	CRP F2 F3 NPR2 PLAT PLG
3	muscle	MP:0005369	9.35	F2 F3 NPR2 PLAT REN
4	respiratory system	MP:0005388	9.02	F2 F3 NPR2 PLAT PLG

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Drugs & Therapeutics for Acute Cor Pulmonale

Drugs for Acute Cor Pulmonale (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Heparin

Approved, Investigational

Phase 4

9005-49-6

772 9812414

Synonyms:

101921-26-0

102785-31-9

102-94-3

104521-37-1

11078-24-3

11129-39-8

12656-11-0

37324-73-5

9041-08-1

9045-22-1

9075-96-1

913079-23-9

91449-79-5

AC1L1ROY

ALFA 87-120

ALFA 87-163

ALFA 87-198

ALFA 87-81

ALFA 88-247

Allocinnamic acid

alpha-Heparin

Alpha-Heparin

Ardeparin

Ardeparin sodium

Ariven

Arteven

Bemiparin

Bemiparin sodium

Calcilean

Calciparine

Certoparin

CID8784

cis-.beta.-Carboxystyrene

cis-Cinnamic acid

Clexane

Clivarin

Clivarine

CY 216

Cy 222

Dalteparin

Dalteparin sodium

Depo-Heparin

EINECS 232-681-7

Enoxaparin

Enoxaparin sodium

Eparina

Eparina [DCIT]

Fluxum

FR 860

Fragmin A

Fragmin B

Fragmin IV

Fraxiparin

H 2149

Hed-heparin

Hed-Heparin

Hep Flush Kit in plastic container

Hepalean

heparin

Heparin Cy 216

Heparin CY 216

Heparin Leo

Heparin Lock Flush

Heparin Lock Flush in plastic container

Heparin Lock Flush preservative free

Heparin Lock Flush preservative free in plastic container

Heparin natrium

Heparin sodium

Heparin sodium 1,000 units and sodium chloride 0.9% in plastic container

Heparin sodium 1,000 units in dextrose 5% in plastic container

Heparin sodium 1,000 units in sodium chloride 0.9% in plastic container

Heparin sodium 10,000 units in dextrose 5%

Heparin sodium 10,000 units in dextrose 5% in plastic container

Heparin sodium 10,000 units in sodium chloride 0.45%

Heparin sodium 10,000 units in sodium chloride 0.9%

Heparin sodium 12,500 units in dextrose 5%

Heparin sodium 12,500 units in dextrose 5% in plastic container

Heparin sodium 12,500 units in sodium chloride 0.45% in plastic container

Heparin sodium 12,500 units in sodium chloride 0.9%

Heparin sodium 2,000 units and sodium chloride 0.9% in plastic container

Heparin sodium 2,000 units in dextrose 5% in plastic container

Heparin sodium 2,000 units in sodium chloride 0.9% in plastic container

Heparin sodium 20,000 units and dextrose 5% in plastic container

Heparin sodium 20,000 units in dextrose 5% in plastic container

Heparin sodium 25,000 units and dextrose 5% in plastic container

Heparin sodium 25,000 units in dextrose 5%

Heparin sodium 25,000 units in dextrose 5% in plastic container

Heparin sodium 25,000 units in sodium chloride 0.45% in plastic container

Heparin sodium 25,000 units in sodium chloride 0.9%

Heparin sodium 25,000 units in sodium chloride 0.9% in plastic container

Heparin sodium 5,000 units and sodium chloride 0.9% in plastic container

Heparin sodium 5,000 units in dextrose 5% in plastic container

Heparin sodium 5,000 units in sodium chloride 0.45%

Heparin sodium 5,000 units in sodium chloride 0.9%

Heparin sodium 5,000 units in sodium chloride 0.9% in plastic container

Heparin sodium in plastic container

Heparin sodium preservative Free

Heparin sodium salt

Heparin sulfate

Heparin sulphate

Heparin, sodium salt

Heparina

Heparina [INN-Spanish]

Heparinate

Heparine

Heparine [INN-French]

Heparinic acid

Heparinsodiumsalt

Heparinum

Heparinum [INN-Latin]

Heparinum natricum

Hepathrom

Hepflush-10

Hep-Lock

Hep-Lock U/P

HSDB 3094

Innohep

Inno-Hep

Isocinnamic acid

Kabi 2165

KB 101

Leparan

LHN 1

Lioton 1000

Lipo-hepin

Lipo-Hepin

Liquaemin

Liquaemin Lock Flush

Liquaemin Sodium

Liquaemin sodium preservative free

Liquemin

Logiparin

Low molecular weight heparin sodium

Minolteparin sodium

MolPort-003-760-257

Multiparin

Nadroparin

Nadroparine

Novoheparin

NSC174025

Octaparin

OP 386

OP 622

Pabyrin

Panheprin

Parnaparin

Parnaparin sodium

Parvoparin

Pularin

Reviparin

Reviparin sodium

Ro 11

Sandoparin

Sodium acid heparin

Sodium heparin

Sodium heparinate

Subeparin

Sublingula

Thromboliquine

Tinzaparin

Tinzaparin sodium

Triofiban

Unfractionated heparin

UNII-12M44VTJ7B

UNII-3S182ET3UA

UNII-E47C0NF7LV

UNII-T2410KM04A

UNII-ZZ45AB24CA

Vetren

Vitrum AB

WY 90493RD

Apixaban

Approved

Phase 4

503612-47-3

10182969

Synonyms:

1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahyd

2p16

503612-47-3

AKOS005146204

Apixaban

apixabán

Apixaban (JAN/USAN/INN)

apixabanum

BMS 562247-01

BMS-562247

BMS-562247-01

BMS-562247-01, Apixaban

CHEBI:49620

CHEMBL231779

CID10182969

D03213

DB07828

Eliquis

GG2

ro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide

S1593_Selleck

UNII-3Z9Y7UWC1J

Antithrombins

Phase 4

Pharmaceutical Solutions

Phase 4

Fibrinolytic Agents

Phase 4

Plasminogen

Phase 4

Serine Proteinase Inhibitors

Phase 4

HIV Protease Inhibitors

Phase 4

Factor Xa Inhibitors

Phase 4

Tissue Plasminogen Activator

Phase 4

Calcium, Dietary

Phase 4

Anticoagulants

Phase 4

calcium heparin

Phase 4

protease inhibitors

Phase 4

Antithrombin III

Phase 4

Serine

Investigational, Nutraceutical

Phase 4

56-45-1

5951

Synonyms:

(-)-Serine

(2S)-2-Amino-3-hydroxypropanoate

(2S)-2-Amino-3-hydroxypropanoic acid

(3R,3'r,6S)-4,5-DIDEHYDRO-5,6-dihydro-b,b-carotene-3,3'-diol

(3R,3'r,6S)-4,5-DIDEHYDRO-5,6-dihydro-BETA,BETA-carotene-3,3'-diol

(3R,3'r,6S)-4,5-DIDEHYDRO-5,6-dihydro-β,β-carotene-3,3'-diol

(S)-(-)-Serine

(S)-2-Amino-3-hydroxypropanoate

(S)-2-Amino-3-hydroxy-propanoate

(S)-2-Amino-3-hydroxypropanoic acid

(S)-2-Amino-3-hydroxy-propanoic acid

(S)-a-Amino-b-hydroxypropionate

(S)-a-Amino-b-hydroxypropionic acid

(S)-alpha-Amino-beta-hydroxypropionate

(S)-alpha-Amino-beta-hydroxypropionic acid

(S)-b-Amino-3-hydroxypropionate

(S)-b-Amino-3-hydroxypropionic acid

(S)-beta-Amino-3-hydroxypropionate

(S)-beta-Amino-3-hydroxypropionic acid

(S)-Serine

(S)-Α-amino-β-hydroxypropionate

(S)-Α-amino-β-hydroxypropionic acid

2-Amino-3-hydroxypropanoate

2-Amino-3-hydroxypropanoic acid

3-Hydroxy-L-alanine

alpha-Amino-beta-hydroxypropionic acid

beta-Hydroxyalanine

beta-Hydroxy-L-alanine

b-Hydroxyalanine

b-Hydroxy-L-alanine

Bo-xan

e 161b

L Serine

L-(-)-Serine

L-2-Amino-3-hydroxypropionate

L-2-Amino-3-hydroxypropionic acid

L-3-Hydroxy-2-aminopropionate

L-3-Hydroxy-2-aminopropionic acid

L-3-Hydroxy-alanine

L-Ser

L-Serin

L-Serine

Ser

Serina

Serine

SERINE

Serinum

Xanthophyll

Β-hydroxyalanine

Β-hydroxy-L-alanine

Calcium

Nutraceutical

Phase 4

7440-70-2

271

Synonyms:

Ca(2+)

Ca2+

Calcio

Calcium

Calcium element

CALCIUM ion

Calcium(2+)

Calcium, doubly charged positive ion

Calcium, elemental

Elemental calcium

Kalzium

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Standard-dose Apixaban AFtEr Very Low-dose ThromboLYSis for Acute Intermediate-high Risk Acute Pulmonary Embolism	Suspended	NCT03988842	Phase 4	Alteplase;Unfractionated heparin;Placebo;Apixaban
2	Continuous Aspiration Thrombectomy in High and Intermediate-high Risk Pulmonary Embolism Patients	Recruiting	NCT04473560

Search NIH Clinical Center for Acute Cor Pulmonale

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Genetic Tests for Acute Cor Pulmonale

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Anatomical Context for Acute Cor Pulmonale

MalaCards organs/tissues related to Acute Cor Pulmonale:

⁴⁰

Lung, Breast

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Publications for Acute Cor Pulmonale

Articles related to Acute Cor Pulmonale:

(show top 50) (show all 317)

#	Title	Authors	PMID	Year
1	Cor pulmonale: the role of traditional and advanced echocardiography in the acute and chronic settings. ⁶¹	Mandoli GE...Working group of Echocardiography of Italian Society of Cardiology (SIC)	32860180	2021
2	The clot thickens: role of mechanical thrombectomy in intermediate to high-risk pulmonary embolism in the peri-operative setting-a case report. ⁶¹	Planek MIC...Attanasio S	33569531	2021
3	Almitrine Infusion in Severe Acute Respiratory Syndrome Coronavirus 2-Induced Acute Respiratory Distress Syndrome: A Single-Center Observational Study. ⁶¹	Caplan M...Lille Intensive Care COVID-19 Group	33093279	2021
4	Usefulness of Right Ventricular Longitudinal Shortening Fraction to Detect Right Ventricular Dysfunction in Acute Cor Pulmonale Related to COVID-19. ⁶¹	Beyls C...Mahjoub Y	33558133	2021
5	Effects of Thrombolytic Therapy in Low-Risk Patients With Pulmonary Embolism. ⁶¹	Stein PD...Hughes MJ	32991851	2021
6	Severe COVID-19 with acute respiratory distress syndrome (ARDS) in a sickle cell disease adult patient: case report. ⁶¹	Teulier M...Fartoukh M	33514354	2021
7	Recombinant tissue plasminogen activator treatment for COVID-19 associated ARDS and acute cor pulmonale. ⁶¹	Kosanovic D...Avdeev SN	33352323	2021
8	Trend of in-hospital deaths by pulmonary embolism in Ecuador. Findings from 2011-2018 national reports. ⁶¹	Garrido D...Pullas G	33321283	2020
9	Surviving 2019 novel coronavirus pneumonia: A successful critical case report. ⁶¹	Zou L...Shi Q	32861887	2020
10	Early signs of right ventricular systolic and diastolic dysfunction in acute severe respiratory failure: the importance of diastolic restrictive pattern. ⁶¹	Tavazzi G...Price S	31762290	2020
11	Catheter-Directed Thrombolysis in Submassive Pulmonary Embolism and Acute Cor Pulmonale. ⁶¹	Stein PD...Hughes MJ	32718549	2020
12	Acute cor pulmonale from saddle pulmonary embolism in a patient with previous COVID-19: should we prolong prophylactic anticoagulation? ⁶¹	Ali S...Pappachan JM	32544670	2020
13	Death due to Cardiac Arrest in a Young Female With Highly Suspected COVID-19: A Case Report. ⁶¹	Mohamed S...Baioumy A	33005541	2020
14	Acute Cor Pulmonale in COVID-19-Related ARDS: Improvement With Almitrine Infusion. ⁶¹	Huette P...Mahjoub Y	32835274	2020
15	Pulmonary hypertension with adult respiratory distress syndrome: prevalence, clinical impact, and association with central venous pressure. ⁶¹	Li DK...Wang XT	32699608	2020
16	Acute Cor Pulmonale in Critically Ill Patients with Covid-19. ⁶¹	Creel-Bulos C...Sharifpour M	32374956	2020
17	[Cor pulmonale]. ⁶¹	Aubry A...Vieillard-Baron A	32088063	2020
18	Aorto-caval fistula - case report. ⁶¹	Houdek K...Treska V	32545976	2020
19	The harm of high-frequency oscillatory ventilation (HFOV) in ARDS is not related to a high baseline risk of acute cor pulmonale or short-term changes in hemodynamics. ⁶¹	Angriman F...Adhikari NKJ	31664500	2020
20	[A Chinese consensus statement on the clinical application of transesophageal echocardiography for critical care (2019)]. ⁶¹	Yin WH...Critical Hemodynamic Therapy Collaboration Group	31775449	2019
21	A cross-sectional study of acute cor pulmonale in acute respiratory distress syndrome patients in China. ⁶¹	Su LX...Chinese Critical Ultrasound Study Group (CCUSG)	31856056	2019
22	Feasibility and safety of ultra-low tidal volume ventilation without extracorporeal circulation in moderately severe and severe ARDS patients. ⁶¹	Richard JC...REVA research network	31549225	2019
23	Pulmonary Dead Space Monitoring: Identifying Subjects With ARDS at Risk of Developing Right Ventricular Dysfunction. ⁶¹	Papolos AI...Matthay MA	31138736	2019
24	Unusual case of intraoperative acute cor pulmonale during spine surgery. ⁶¹	Mohan B...Wander GS	30971611	2019
25	A Nonfatal Massive Pulmonary Embolism in a Very Old Patient: The Protective Filter-Effect of the Chiari Network. ⁶¹	Sonaglioni A...Anza C	31008038	2019
26	Acute Cor Pulmonale in Veno-Venous Extracorporeal Membrane Oxygenation: Three Case Reports. ⁶¹	Dong ER...Nurok M	29324515	2018
27	Physiology-guided management of hemodynamics in acute respiratory distress syndrome. ⁶¹	Cortes-Puentes GA...Marini JJ	30370280	2018
28	Paradoxical brain embolism shadowing massive pulmonary embolism. ⁶¹	Bagate F...Carteaux G	29792264	2018
29	Re-examining Permissive Hypercapnia in ARDS: A Narrative Review. ⁶¹	Barnes T...Parhar K	29175086	2018
30	[Recognizing rare cardiac diseases by electrocardiogram]. ⁶¹	Grimm W...Efimova E	29619572	2018
31	Acute Respiratory Distress Syndrome: Challenge for Diagnosis and Therapy. ⁶¹	Pan C...Qiu HB	29595185	2018
32	Hemodynamic Assessment of Patients With Septic Shock Using Transpulmonary Thermodilution and Critical Care Echocardiography: A Comparative Study. ⁶¹	Vignon P...Riu-Poulenc B	28866112	2018
33	Adverse Heart-Lung Interactions in Ventilator-induced Lung Injury. ⁶¹	Katira BH...Kavanagh BP	28795839	2017
34	Frequency and prognostic impact of basic critical care echocardiography abnormalities in patients with acute respiratory distress syndrome. ⁶¹	See KC...Phua J	29260440	2017
35	[Experts consensus on the management of the right heart function in critically ill patients]. ⁶¹	Wang XT...Critical Hemodynamic Theraphy Collaboration Group (CHTC Group)	29202543	2017
36	Intraoperative Pulmonary Embolism: A Case Report Emphasizing the Utility of Electrocardiogram. ⁶¹	Pleticha J...Sutton EM	28767474	2017
37	Pulmonary tumor embolism secondary to soft tissue and bone sarcomas: a case report and literature review. ⁶¹	Latchana N...Pollock RE	28854949	2017
38	Right heart function during acute respiratory distress syndrome. ⁶¹	Repesse X...Vieillard-Baron A	28828370	2017
39	The Spectrum of Changes in the Right Ventricle in ARDS: Dilatation, Dysfunction, and Acute Cor Pulmonale. ⁶¹	Lazzeri C...Peris A	28693765	2017
40	Incidence Proportion of Acute Cor Pulmonale in Patients with Acute Respiratory Distress Syndrome Subjected to Lung Protective Ventilation: A Systematic Review and Meta-analysis. ⁶¹	Das SK...Lahkar A	28701843	2017
41	Acute cor pulmonale due to pulmonary tumour thrombotic microangiopathy from renal cell carcinoma. ⁶¹	Story M...Fortis S	28659364	2017
42	Transient right bundle branch block in a patient with acute pulmonary embolism. ⁶¹	Gonzva J...Tourtier JP	27817836	2017
43	[Acute cor pulmonale in acute respiratory distress syndrome]. ⁶¹	Zhang F...Zuo X	28627352	2017
44	Extracorporeal life support for refractory ventricular tachycardia. ⁶¹	Bhandary SP...Papadimos TJ	28275618	2017
45	Acute cor pulmonale due to pulmonary tumor thrombotic microangiopathy in two patients with breast cancer. ⁶¹	Moon SY...Yoon SY	26842105	2017
46	Pulmonary Vascular Dysfunction and Cor Pulmonale During Acute Respiratory Distress Syndrome in Sicklers. ⁶¹	Cecchini J...Mekontso Dessap A	27206275	2016
47	Rationale and Description of Right Ventricle-Protective Ventilation in ARDS. ⁶¹	Paternot A...Vieillard-Baron A	27484108	2016
48	Syncope and Dyspnea and Pulmonary Embolism. ⁶¹	Glancy DL	27269586	2016
49	Massive pulmonary embolism with acute cor pulmonale. ⁶¹	Nelson AJ...Parvar SL	26984674	2016
50	Guidelines for the Appropriate Use of Bedside General and Cardiac Ultrasonography in the Evaluation of Critically Ill Patients-Part II: Cardiac Ultrasonography. ⁶¹	Levitov A...Elbarbary M	27182849	2016

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Genes for Acute Cor Pulmonale

Genes related to Acute Cor Pulmonale (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NPPB	Natriuretic Peptide B	Protein Coding	12.53	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	PLG	Plasminogen	Protein Coding	5.35	DISEASES inferred ¹⁵
3	F3	Coagulation Factor III, Tissue Factor	Protein Coding	5.15	DISEASES inferred ¹⁵
4	PLAT	Plasminogen Activator, Tissue Type	Protein Coding	4.82	DISEASES inferred ¹⁵
5	TSPAN15	Tetraspanin 15	Protein Coding	4.63	DISEASES inferred ¹⁵
6	F2	Coagulation Factor II, Thrombin	Protein Coding	4.55	DISEASES inferred ¹⁵
7	NPR2	Natriuretic Peptide Receptor 2	Protein Coding	4.52	DISEASES inferred ¹⁵
8	REN	Renin	Protein Coding	4.51	DISEASES inferred ¹⁵
9	CRP	C-Reactive Protein	Protein Coding	4.41	DISEASES inferred ¹⁵

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Variations for Acute Cor Pulmonale

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Expression for Acute Cor Pulmonale

Search GEO for disease gene expression data for Acute Cor Pulmonale.

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Pathways for Acute Cor Pulmonale

Pathways related to Acute Cor Pulmonale according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Folate Metabolism ¹ Show member pathways Selenium Micronutrient Network ¹ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	11.79	PLG PLAT F2 CRP
2	Formation of Fibrin Clot (Clotting Cascade) ⁶⁵ Show member pathways Blood Clotting Cascade ¹ Blood Coagulation Signaling Pathways ⁶⁴ Common Pathway of Fibrin Clot Formation ⁶⁵ Extrinsic Pathway of Fibrin Clot Formation ⁶⁵ Extrinsic Prothrombin Activation Pathway ⁶³ Intrinsic Pathway of Fibrin Clot Formation ⁶⁵	11.46	PLG PLAT F3 F2
3	Complement and coagulation cascades ³⁶ ¹	11.09	PLG PLAT F3 F2
4	Syndecan-4-mediated signaling events ¹	10.9	PLG F2
5	A-beta Pathways: Plaque Formation and APP Metabolism ⁶⁴	10.73	PLG PLAT
6	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) ⁶⁵	10.64	PLG F2
7	Dissolution of Fibrin Clot ⁶⁵	10.37	PLG PLAT

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GO Terms for Acute Cor Pulmonale

Cellular components related to Acute Cor Pulmonale according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell surface	GO:0009986	9.56	TSPAN15 PLG PLAT F3
2	extracellular region	GO:0005576	9.5	REN PLG PLAT NPPB F3 F2
3	collagen-containing extracellular matrix	GO:0062023	9.46	PLG PLAT F3 F2
4	extracellular space	GO:0005615	9.17	REN PLG PLAT NPPB F3 F2

Biological processes related to Acute Cor Pulmonale according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	proteolysis	GO:0006508	9.78	REN PLG PLAT F2
2	cellular protein metabolic process	GO:0044267	9.67	TSPAN15 PLG F2
3	acute-phase response	GO:0006953	9.51	F2 CRP
4	negative regulation of proteolysis	GO:0045861	9.46	PLAT F2
5	cGMP-mediated signaling	GO:0019934	9.43	NPR2 NPPB
6	regulation of blood pressure	GO:0008217	9.43	REN NPR2 NPPB
7	cGMP biosynthetic process	GO:0006182	9.4	NPR2 NPPB
8	negative regulation of fibrinolysis	GO:0051918	9.37	PLG F2
9	hemostasis	GO:0007599	9.33	PLG F3 F2
10	receptor guanylyl cyclase signaling pathway	GO:0007168	9.32	NPR2 NPPB
11	blood coagulation	GO:0007596	9.26	PLG PLAT F3 F2
12	fibrinolysis	GO:0042730	8.8	PLG PLAT F2

Molecular functions related to Acute Cor Pulmonale according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	peptidase activity	GO:0008233	9.56	REN PLG PLAT F2
2	serine-type peptidase activity	GO:0008236	9.33	PLG PLAT F2
3	serine-type endopeptidase activity	GO:0004252	9.26	PLG PLAT F3 F2
4	signaling receptor binding	GO:0005102	9.02	REN PLG PLAT NPPB F2

Sources

Sources for Acute Cor Pulmonale

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia