MCID: ACT056
MIFTS: 36

Acute Cor Pulmonale

Categories: Cardiovascular diseases

Aliases & Classifications for Acute Cor Pulmonale

MalaCards integrated aliases for Acute Cor Pulmonale:

Name: Acute Cor Pulmonale 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:8517
ICD9CM 34 415.0
SNOMED-CT 67 49584005
ICD10 32 I26.09
UMLS 71 C0155672

Summaries for Acute Cor Pulmonale

MalaCards based summary : Acute Cor Pulmonale is related to pulmonary embolism and thrombophilia due to thrombin defect. An important gene associated with Acute Cor Pulmonale is NPPB (Natriuretic Peptide B), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. The drugs Heparin and Apixaban have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and breast.

Related Diseases for Acute Cor Pulmonale

Diseases related to Acute Cor Pulmonale via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 pulmonary embolism 32.0 PLAT NPPB F3
2 thrombophilia due to thrombin defect 30.2 PLAT F3
3 thrombosis 30.2 PLG PLAT F3
4 pulmonary valve insufficiency 30.2 WBP2NL PDZK1IP1 NPPB
5 pulmonary hypertension 30.0 PLG PLAT NPPB F3
6 intracranial thrombosis 29.8 PLG PLAT F3
7 tricuspid valve insufficiency 29.6 WBP2NL PDZK1IP1 NPPB F3
8 patent foramen ovale 29.6 PLG PLAT PDZK1IP1 NPPB F3
9 respiratory failure 10.4
10 pneumonia 10.3
11 cardiogenic shock 10.3 PLAT NPPB
12 anterolateral myocardial infarction 10.3 PLAT NPPB
13 pulmonary valve disease 10.3 PDZK1IP1 NPPB
14 aortic valve insufficiency 10.2 PDZK1IP1 NPPB
15 schistosoma mansoni infection, susceptibility/ 10.2
16 cardiac arrest 10.2
17 covid-19 10.2
18 pulmonary edema 10.2
19 schistosomiasis 10.2
20 thrombotic microangiopathy 10.2
21 mitral valve insufficiency 10.2 PDZK1IP1 NPPB
22 ligneous conjunctivitis 10.2 PLG PLAT
23 anterior cerebral artery infarction 10.2 PLG PLAT
24 lujo hemorrhagic fever 10.2 NPPB F3
25 basilar artery occlusion 10.2 PLG PLAT
26 basal ganglia cerebrovascular disease 10.2 PLG PLAT
27 thoracic outlet syndrome 10.2 PLG PLAT
28 vertebral artery occlusion 10.2 PLG PLAT
29 brain stem infarction 10.2 PLG PLAT
30 conversion disorder 10.1 PLG PLAT
31 hereditary angioedema with normal c1inh 10.1 PLG PLAT
32 middle cerebral artery infarction 10.1 PLG PLAT
33 central retinal artery occlusion 10.1 PLG PLAT
34 encephalopathy, familial, with neuroserpin inclusion bodies 10.1 PLG PLAT
35 obstructive hydrocephalus 10.1 PLG PLAT
36 facial nerve disease 10.1 PLG PLAT
37 medulloadrenal hyperfunction 10.1 PLG F3
38 carotid artery occlusion 10.1 PLG PLAT
39 carotid artery thrombosis 10.1 PLAT F3
40 alcohol dependence 10.1
41 progressive familial heart block, type ia 10.1
42 hepatocellular carcinoma 10.1
43 renal cell carcinoma, nonpapillary 10.1
44 myxoma, intracardiac 10.1
45 osteogenic sarcoma 10.1
46 progressive familial heart block, type ib 10.1
47 renal cell carcinoma, papillary, 1 10.1
48 cyanosis, transient neonatal 10.1
49 metabolic acidosis 10.1
50 portal hypertension 10.1

Comorbidity relations with Acute Cor Pulmonale via Phenotypic Disease Network (PDN): (show all 11)


Acute Cystitis Anxiety
Bronchitis Chronic Pulmonary Heart Disease
Familial Atrial Fibrillation Heart Disease
Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome Osteoporosis
Postinflammatory Pulmonary Fibrosis Pulmonary Hypertension, Primary, 1
Respiratory Failure

Graphical network of the top 20 diseases related to Acute Cor Pulmonale:



Diseases related to Acute Cor Pulmonale

Symptoms & Phenotypes for Acute Cor Pulmonale

Drugs & Therapeutics for Acute Cor Pulmonale

Drugs for Acute Cor Pulmonale (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
2
Apixaban Approved Phase 4 503612-47-3 10182969
3 Antithrombins Phase 4
4 Fibrinolytic Agents Phase 4
5 Antithrombin III Phase 4
6 Serine Proteinase Inhibitors Phase 4
7 Factor Xa Inhibitors Phase 4
8
protease inhibitors Phase 4
9 Tissue Plasminogen Activator Phase 4
10 Pharmaceutical Solutions Phase 4
11 HIV Protease Inhibitors Phase 4
12 Plasminogen Phase 4
13 Anticoagulants Phase 4
14 Calcium, Dietary Phase 4
15 calcium heparin Phase 4
16
Serine Investigational, Nutraceutical Phase 4 56-45-1 5951
17
Calcium Nutraceutical Phase 4 7440-70-2 271
18
tannic acid Approved Phase 2, Phase 3 1401-55-4
19
Phenylephrine Approved Phase 2, Phase 3 59-42-7 6041
20
Norepinephrine Approved Phase 2, Phase 3 51-41-2 439260
21
Pseudoephedrine Approved Phase 2, Phase 3 90-82-4 7028
22
Ephedrine Approved Phase 2, Phase 3 299-42-3 9294
23
Oxymetazoline Approved, Investigational Phase 2, Phase 3 1491-59-4 4636
24
Epinephrine Approved, Vet_approved Phase 2, Phase 3 51-43-4 5816
25
Racepinephrine Approved Phase 2, Phase 3 329-65-7 838
26
Dopamine Approved Phase 2, Phase 3 51-61-6, 62-31-7 681
27
Benzocaine Approved, Investigational Phase 2, Phase 3 94-09-7, 1994-09-7 2337
28 Respiratory System Agents Phase 2, Phase 3
29 Adrenergic alpha-Agonists Phase 2, Phase 3
30 Adrenergic beta-Agonists Phase 2, Phase 3
31 Dopamine Agents Phase 2, Phase 3
32 Cardiotonic Agents Phase 2, Phase 3
33 Vasoconstrictor Agents Phase 2, Phase 3
34 Central Nervous System Stimulants Phase 2, Phase 3
35 Adrenergic Agents Phase 2, Phase 3
36 Nasal Decongestants Phase 2, Phase 3
37 Epinephryl borate Phase 2, Phase 3
38 Anesthetics Phase 2, Phase 3
39 Adrenergic Agonists Phase 2, Phase 3
40 Neurotransmitter Agents Phase 2, Phase 3
41 Protective Agents Phase 2, Phase 3
42 Anti-Asthmatic Agents Phase 2, Phase 3
43 Bronchodilator Agents Phase 2, Phase 3
44 Sympathomimetics Phase 2, Phase 3
45 Mydriatics Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Standard-dose Apixaban AFtEr Very Low-dose ThromboLYSis for Acute Intermediate-high Risk Acute Pulmonary Embolism Not yet recruiting NCT03988842 Phase 4 Alteplase;Unfractionated heparin;Placebo;Apixaban
2 Effect of Target Intraoperative Blood Pressure on the Incidence of Post-operative Cognitive Dysfunction in Patients Aged 75 and Older Undergoing General Anesthesia for Non-cardiac Surgery: an International Multicenter Randomized Controlled Trial Suspended NCT02428062 Phase 2, Phase 3 Phenylephrine;Intravenous fluids;Ephedrine;Epinephrine;Norepinephrine;Dopamine
3 NT-proBNP: a Useful Tool for the Detection of Acute Pulmonary Artery Embolism in Post-surgical Patients Completed NCT01633671
4 ImaCor II Effects of Hemodynamic Monitoring Using the ImaCor Single Use Transesophageal Echocardiography Probe in Critically Ill Patients - a Randomized Controlled Trial Completed NCT02048566
5 Hemodynamic Effects of PEEP in Patients With ARDS Recruiting NCT03896802
6 Prone Positioning During High Flow Oxygen Therapy in Patients With Acute Hypoxemic Respiratory Failure: a Pilot Physiological Trial Recruiting NCT03095300

Search NIH Clinical Center for Acute Cor Pulmonale

Genetic Tests for Acute Cor Pulmonale

Anatomical Context for Acute Cor Pulmonale

MalaCards organs/tissues related to Acute Cor Pulmonale:

40
Heart, Lung, Breast, Brain, Liver, Bone, Testes

Publications for Acute Cor Pulmonale

Articles related to Acute Cor Pulmonale:

(show top 50) (show all 303)
# Title Authors PMID Year
1
Acute cor pulmonale from saddle pulmonary embolism in a patient with previous Covid-19 - should we prolong prophylactic anticoagulation? 61
32544670 2020
2
Acute Cor Pulmonale in Critically Ill Patients with Covid-19. 61
32374956 2020
3
[Cor pulmonale]. 61
32088063 2020
4
Aorto-caval fistula - case report. 61
32545976 2020
5
The harm of high-frequency oscillatory ventilation (HFOV) in ARDS is not related to a high baseline risk of acute cor pulmonale or short-term changes in hemodynamics. 61
31664500 2020
6
[A Chinese consensus statement on the clinical application of transesophageal echocardiography for critical care (2019)]. 61
31775449 2019
7
A cross-sectional study of acute cor pulmonale in acute respiratory distress syndrome patients in China. 61
31856056 2019
8
A cross-sectional study of acute cor pulmonale in acute respiratory distress syndrome patients in China. 61
31764188 2019
9
Early signs of right ventricular systolic and diastolic dysfunction in acute severe respiratory failure: the importance of diastolic restrictive pattern. 61
31762290 2019
10
Feasibility and safety of ultra-low tidal volume ventilation without extracorporeal circulation in moderately severe and severe ARDS patients. 61
31549225 2019
11
Pulmonary Dead Space Monitoring: Identifying Subjects With ARDS at Risk of Developing Right Ventricular Dysfunction. 61
31138736 2019
12
Unusual case of intraoperative acute cor pulmonale during spine surgery. 61
30971611 2019
13
A Nonfatal Massive Pulmonary Embolism in a Very Old Patient: The Protective Filter-Effect of the Chiari Network. 61
31008038 2019
14
Acute Cor Pulmonale in Veno-Venous Extracorporeal Membrane Oxygenation: Three Case Reports. 61
29324515 2018
15
Physiology-guided management of hemodynamics in acute respiratory distress syndrome. 61
30370280 2018
16
Paradoxical brain embolism shadowing massive pulmonary embolism. 61
29792264 2018
17
Re-examining Permissive Hypercapnia in ARDS: A Narrative Review. 61
29175086 2018
18
[Recognizing rare cardiac diseases by electrocardiogram]. 61
29619572 2018
19
Acute Respiratory Distress Syndrome: Challenge for Diagnosis and Therapy. 61
29595185 2018
20
Hemodynamic Assessment of Patients With Septic Shock Using Transpulmonary Thermodilution and Critical Care Echocardiography: A Comparative Study. 61
28866112 2018
21
Adverse Heart-Lung Interactions in Ventilator-induced Lung Injury. 61
28795839 2017
22
[Experts consensus on the management of the right heart function in critically ill patients]. 61
29202543 2017
23
Frequency and prognostic impact of basic critical care echocardiography abnormalities in patients with acute respiratory distress syndrome. 61
29260440 2017
24
Intraoperative Pulmonary Embolism: A Case Report Emphasizing the Utility of Electrocardiogram. 61
28767474 2017
25
Pulmonary tumor embolism secondary to soft tissue and bone sarcomas: a case report and literature review. 61
28854949 2017
26
Right heart function during acute respiratory distress syndrome. 61
28828370 2017
27
The Spectrum of Changes in the Right Ventricle in ARDS: Dilatation, Dysfunction, and Acute Cor Pulmonale. 61
28693765 2017
28
Incidence Proportion of Acute Cor Pulmonale in Patients with Acute Respiratory Distress Syndrome Subjected to Lung Protective Ventilation: A Systematic Review and Meta-analysis. 61
28701843 2017
29
Acute cor pulmonale due to pulmonary tumour thrombotic microangiopathy from renal cell carcinoma. 61
28659364 2017
30
Transient right bundle branch block in a patient with acute pulmonary embolism. 61
27817836 2017
31
[Acute cor pulmonale in acute respiratory distress syndrome]. 61
28627352 2017
32
Extracorporeal life support for refractory ventricular tachycardia. 61
28275618 2017
33
Acute cor pulmonale due to pulmonary tumor thrombotic microangiopathy in two patients with breast cancer. 61
26842105 2017
34
Rationale and Description of Right Ventricle-Protective Ventilation in ARDS. 61
27484108 2016
35
Pulmonary Vascular Dysfunction and Cor Pulmonale During Acute Respiratory Distress Syndrome in Sicklers. 61
27206275 2016
36
Syncope and Dyspnea and Pulmonary Embolism. 61
27269586 2016
37
Massive pulmonary embolism with acute cor pulmonale. 61
26984674 2016
38
Guidelines for the Appropriate Use of Bedside General and Cardiac Ultrasonography in the Evaluation of Critically Ill Patients-Part II: Cardiac Ultrasonography. 61
27182849 2016
39
Assessment of the effects of inspiratory load on right ventricular function. 61
27054626 2016
40
Experts' opinion on management of hemodynamics in ARDS patients: focus on the effects of mechanical ventilation. 61
27038480 2016
41
Acute cor pulmonale and the acute respiratory distress syndrome. 61
26759013 2016
42
Acute cor pulmonale during protective ventilation for acute respiratory distress syndrome: prevalence, predictors, and clinical impact. 61
26650055 2016
43
Preventing the development of acute cor pulmonale in patients with acute respiratory distress syndrome: the first step. 61
27162796 2016
44
The potential role and limitations of echocardiography in acute respiratory distress syndrome. 61
26660667 2016
45
Focused cardiac and lung ultrasonography: implications and applicability in the perioperative period. 61
28913476 2016
46
Pulmonary vascular dysfunction in refractory acute respiratory distress syndrome before veno-venous extracorporeal membrane oxygenation. 61
26482659 2016
47
Acute respiratory distress syndrome: the heart side of the moon. 61
26627538 2016
48
Electrical impedance tomography-guided prone positioning in a patient with acute cor pulmonale associated with severe acute respiratory distress syndrome. 61
26446805 2016
49
Hemodynamics of Acute Right Heart Failure in Mechanically Ventilated Patients with Acute Respiratory Distress Syndrome. 61
26567491 2015
50
Fatal foreign-body granulomatous pulmonary embolization due to microcrystalline cellulose in a patient receiving total parenteral nutrition: all crystals are not what they seem. 61
25737334 2015

Variations for Acute Cor Pulmonale

Expression for Acute Cor Pulmonale

Search GEO for disease gene expression data for Acute Cor Pulmonale.

Pathways for Acute Cor Pulmonale

GO Terms for Acute Cor Pulmonale

Biological processes related to Acute Cor Pulmonale according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.33 PLG PLAT F3
2 hemostasis GO:0007599 9.26 PLG F3
3 fibrinolysis GO:0042730 8.96 PLG PLAT
4 trans-synaptic signaling by BDNF, modulating synaptic transmission GO:0099183 8.62 PLG PLAT

Molecular functions related to Acute Cor Pulmonale according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 8.8 PLG PLAT F3

Sources for Acute Cor Pulmonale

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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