Aliases & Classifications for Acute Cystitis

MalaCards integrated aliases for Acute Cystitis:

Name: Acute Cystitis 12 15 73
Urinary Tract Infection 12 73
Recurrent Urinary Tract Infection 73
Urinary Tract Infections 43

Classifications:



External Ids:

Disease Ontology 12 DOID:13148
ICD10 33 N30.0 N39.0
ICD9CM 35 595.0
NCIt 50 C26934

Summaries for Acute Cystitis

MedlinePlus : 43 The urinary system is the body's drainage system for removing wastes and extra water. It includes two kidneys, two ureters, a bladder, and a urethra. Urinary tract infections (UTIs) are the second most common type of infection in the body. You may have a UTI if you notice Pain or burning when you urinate Fever, tiredness, or shakiness An urge to urinate often Pressure in your lower belly Urine that smells bad or looks cloudy or reddish Pain in your back or side below the ribs People of any age or sex can get UTIs. But about four times as many women get UTIs as men. You're also at higher risk if you have diabetes, need a tube to drain your bladder, or have a spinal cord injury. If you think you have a UTI it is important to see your doctor. Your doctor can tell if you have a UTI with a urine test. Treatment is with antibiotics. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Acute Cystitis, also known as urinary tract infection, is related to cystitis and acute pyelonephritis, and has symptoms including fever, pruritus and uti symptoms. An important gene associated with Acute Cystitis is IL6 (Interleukin 6), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Immune response IL-23 signaling pathway. The drugs Ibuprofen and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and spinal cord.

Disease Ontology : 12 A cystitis characterized by a sudden onset or severe symptoms.

Wikipedia : 76 A urinary tract infection (UTI) is an infection that affects part of the urinary tract. When it affects... more...

Related Diseases for Acute Cystitis

Diseases in the Cystitis family:

Acute Cystitis Chronic Cystitis

Diseases related to Acute Cystitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 136)
# Related Disease Score Top Affiliating Genes
1 cystitis 32.0 CRP CXCL8 IL6 UPK1A
2 acute pyelonephritis 29.8 ALB CRP CXCL8 IL6
3 pyelonephritis 29.6 ALB CCL2 CRP CXCL8 IL6
4 meningitis 29.0 ALB CCL2 CRP CXCL1 CXCL8 IL6
5 urinary tract infections, recurrent 12.5
6 neonatal urinary tract infectious disease 11.5
7 cold agglutinin disease 10.9 CRP IL6
8 cryopyrin-associated periodic syndrome 10.8 CRP IL6
9 splenic abscess 10.8 CRP IER3IP1
10 cardiogenic shock 10.8 CRP IL6
11 acute cholangitis 10.8 CRP IL6
12 retinitis pigmentosa 73 10.8 CCL2 CXCL1
13 anterior uveitis 10.8 CCL2 IL6
14 neutrophilia, hereditary 10.8 CRP IL6
15 stachybotrys chartarum 10.8 CCL2 IL18 IL6
16 recurrent corneal erosion 10.7 CXCL8 IL6
17 uremic pruritus 10.7 CRP IL18 IL6
18 bagassosis 10.7 CXCL8 IL6
19 adult-onset still's disease 10.7 CRP IL18 IL6
20 herpes simplex virus keratitis 10.7 CCL2 CXCL8
21 peripheral artery disease 10.7 CCL2 CRP IL6
22 neonatal hypothyroidism 10.7 ADCY10 SLC5A5
23 temporal arteritis 10.7 CCL2 CRP IL6
24 acute transverse myelitis 10.7 CXCL8 IL6
25 streptococcal toxic-shock syndrome 10.7 CXCL8 IL6
26 spinal disease 10.7 CRP IL6
27 aortic aneurysm, familial abdominal, 1 10.7 CCL2 CRP IL6
28 overnutrition 10.6 CCL2 CRP IL6
29 juvenile rheumatoid arthritis 10.6 CRP IL18 IL6
30 castleman disease 10.6 CRP IL6
31 israeli tick typhus 10.6 CCL2 CXCL8
32 abdominal tuberculosis 10.6 ALB CRP
33 atherosclerosis susceptibility 10.6 CCL2 CRP IL6
34 slow-channel congenital myasthenic syndrome 10.6 CRP CXCL8
35 denture stomatitis 10.6 CCL2 CXCL8 IL6
36 papillary conjunctivitis 10.6 CXCL8 IL6
37 hypersensitivity reaction type iii disease 10.5 ALB CRP IL6
38 viral encephalitis 10.5 CCL2 CXCL8 IL6
39 prediabetes syndrome 10.5 ALB CRP IL6
40 melancholia 10.5 CRP IER3IP1
41 fasciitis 10.5 CXCL8 IL18 IL6
42 pleural tuberculosis 10.5 CCL2 CXCL8 IL18
43 urethral calculus 10.5 KLK3 MCU
44 hemorrhagic fever with renal syndrome 10.5 ALB CRP IL6
45 intermittent claudication 10.5 ALB CRP IL6
46 iga glomerulonephritis 10.5 ALB CCL2 IL6
47 typhoid fever 10.5 ALB CRP IL6
48 funisitis 10.5 CXCL8 IL6
49 pneumoconiosis 10.5 CCL2 CXCL8 IL6
50 coronary stenosis 10.5 ALB CRP IL6

Comorbidity relations with Acute Cystitis via Phenotypic Disease Network (PDN): (show top 50) (show all 439)


3-Hydroxyacyl-Coa Dehydrogenase Deficiency Acquired Thrombocytopenia
Active Peptic Ulcer Disease Acute Anterolateral Myocardial Infarction
Acute Conjunctivitis Acute Cor Pulmonale
Acute Kidney Failure Acute Maxillary Sinusitis
Acute Myocardial Infarction Acute Pancreatitis
Acute Sphenoidal Sinusitis Acute Vascular Insufficiency of Intestine
Adjustment Disorder Adrenal Gland Disease
Agammaglobulinemia, X-Linked Age-Related Hearing Loss
Alcohol Abuse Alcoholic Hepatitis
Alcoholic Liver Cirrhosis Alcoholic Neuropathy
Algoneurodystrophy Allergic Urticaria
Alopecia, Neurologic Defects, and Endocrinopathy Syndrome Alzheimer Disease
Amnestic Disorder Amyloidosis
Anemia, Autoimmune Hemolytic Anorexia Nervosa
Anus Cancer Anxiety
Aortic Aneurysm Aortic Atherosclerosis
Aortic Valve Disease 1 Asthma
Atrioventricular Block Atrophic Gastritis
Atypical Depressive Disorder Autonomic Nervous System Disease
Bacteremia 2 Bacterial Meningitis
Balanoposthitis Basilar Artery Insufficiency
Benign Essential Hypertension Benign Hypertensive Renal Disease
Biliary Tract Disease Bipolar Disorder
Bladder Cancer Bladder Disease
Bladder Neck Obstruction Bleeding Disorder, Platelet-Type, 11

Graphical network of the top 20 diseases related to Acute Cystitis:



Diseases related to Acute Cystitis

Symptoms & Phenotypes for Acute Cystitis

UMLS symptoms related to Acute Cystitis:


fever, pruritus, uti symptoms

Drugs & Therapeutics for Acute Cystitis

Drugs for Acute Cystitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ibuprofen Approved Phase 4 15687-27-1 3672
2 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1,Not Applicable
3 Antibiotics, Antitubercular Phase 4,Not Applicable
4 Amdinocillin Pivoxil Phase 4
5 Analgesics Phase 4
6 Analgesics, Non-Narcotic Phase 4
7 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
8 Anti-Inflammatory Agents Phase 4
9 Anti-Inflammatory Agents, Non-Steroidal Phase 4
10 Antirheumatic Agents Phase 4
11 Cyclooxygenase Inhibitors Phase 4
12 Peripheral Nervous System Agents Phase 4
13 Renal Agents Phase 4,Phase 2,Not Applicable
14
Cefditoren Approved, Investigational Phase 3 117467-28-4, 104145-95-1 9571074 9870843
15
Ciprofloxacin Approved, Investigational Phase 3,Not Applicable 85721-33-1 2764
16 Cefditoren pivoxil Phase 3
17 Cephalosporins Phase 3
18 Cytochrome P-450 CYP1A2 Inhibitors Phase 3,Not Applicable
19 Cytochrome P-450 Enzyme Inhibitors Phase 3,Not Applicable
20 Topoisomerase Inhibitors Phase 3,Not Applicable
21
Nitrofurantoin Approved, Vet_approved Phase 2,Not Applicable 67-20-9 5353830
22 Cranberry Approved, Investigational, Nutraceutical Phase 2,Not Applicable
23 Trimethoprim, Sulfamethoxazole Drug Combination Phase 2,Not Applicable
24
Cefpodoxime Approved, Vet_approved Not Applicable 82619-04-3, 80210-62-4 6335986
25
Ceftizoxime Approved, Investigational Not Applicable 68401-81-0 6533629
26
Zinc Approved, Investigational Not Applicable 7440-66-6 23994
27
Fosfomycin Approved Not Applicable 23155-02-4 446987
28
Sulfamethoxazole Approved Not Applicable 723-46-6 5329
29
Trimethoprim Approved, Vet_approved Not Applicable 738-70-5 5578
30
Amoxicillin Approved, Vet_approved Not Applicable 26787-78-0 33613
31
Citric Acid Approved, Nutraceutical, Vet_approved Not Applicable 77-92-9 311
32
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved 83-88-5 493570
33
Vitamin C Approved, Nutraceutical 50-81-7 5785 54670067
34 Grape Approved, Nutraceutical Not Applicable
35 Cefpodoxime proxetil Not Applicable
36 Antitubercular Agents ,Not Applicable
37 Anticoagulants Not Applicable
38 Calcium, Dietary Not Applicable
39 Chelating Agents Not Applicable
40 Vitamins
41 Amoxicillin-Potassium Clavulanate Combination Not Applicable
42 beta-Lactamase Inhibitors Not Applicable
43 Clavulanic Acid Not Applicable
44 Acidophilus Nutraceutical Not Applicable
45 Citrate Nutraceutical Not Applicable
46 Vitamin B2 Nutraceutical

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Management of Urinary Tract Infections in Primary Care Facilities. Completed NCT01132131 Phase 4
2 Ibuprofen Versus Mecillinam for Uncomplicated Cystitis Completed NCT01849926 Phase 4 Ibuprofen;Mecillinam
3 Efficacy and Safety of Cefditoren Pivoxil Versus Ciprofloxacin in Acute Uncomplicated Cystitis Completed NCT00598403 Phase 3 cefditoren pivoxil;Ciprofloxacin
4 Comparison in the Treatment of Acute Cystitis Using Cephalosporin and Norfloxacin (CECI) Withdrawn NCT01527019 Phase 3 Norfloxacin;Cephalosporins;Cephalosporins
5 Effect of Adjuvant Treatment With Compound Cranberry Extract Tablets in Acute Bacterial Cystitis. Unknown status NCT00305071 Phase 2 compound cranberry extract tablet
6 Short Course Nitrofurantoin for Acute Cystitis Completed NCT00391651 Phase 2 Nitrofurantoin 100mg twice daily x 5 days;TMP/SMX DS twice daily x 3 days
7 A Bioequivalence Study of SKF101804 Cefixime Versus Cefixime Reference Formulation in Healthy Adults Under Fasting Conditions Withdrawn NCT03329547 Phase 1 Cefixime test capsule;Cefixime reference capsule
8 Cefpodoxime vs Ciprofloxacin for Acute Cystitis Completed NCT00194532 Not Applicable Cefpodoxime;Ciprofloxacin
9 Assessment of UTI Symptoms and Quality of Life According to Antibiotics Treatment in Acute Uncomplicated Cystitis Completed NCT01631955 Ciprobay
10 Clinical Trial of L. Reuteri in Urinary Tract Infections in Non Pregnant Women Completed NCT03019172 Not Applicable
11 Epidemiology of Acute Bacterial Uncomplicated Cystitis in General Practice Completed NCT00958295
12 Observational Study With Mode of Action-Analysis of Cystorenal Cranberry Extract in Patients With Recurrent Urinary Tract Infections Recruiting NCT03019874
13 Single Dose Monurol for Treatment of Acute Cystitis Active, not recruiting NCT00976963 Not Applicable Fosfomycin;TMP/SMX DS
14 Lactobacillus Reuteri for Treatment of Uncomplicated UTI in Pregnant Women Not yet recruiting NCT03362697 Not Applicable Antibiotics
15 The Development and Testing of a Scaling Strategy for a Community-Based Primary Care Antimicrobial Stewardship Program Not yet recruiting NCT03517215 Not Applicable
16 Urell and Pregnancy Terminated NCT01818180 Not Applicable

Search NIH Clinical Center for Acute Cystitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Acute Cystitis

Anatomical Context for Acute Cystitis

MalaCards organs/tissues related to Acute Cystitis:

41
Kidney, Testes, Spinal Cord

Publications for Acute Cystitis

Articles related to Acute Cystitis:

(show top 50) (show all 95)
# Title Authors Year
1
Reevaluation of the Acute Cystitis Symptom Score, a Self-Reporting Questionnaire. Part II. Patient-Reported Outcome Assessment. ( 29883423 )
2018
2
The role of the Acute Cystitis Symptom Score questionnaire for research and antimicrobial stewardship. Validation of the Hungarian version. ( 29732220 )
2018
3
Less workup, longer treatment, but no clinical benefit observed in women with diabetes and acute cystitis. ( 28544925 )
2017
4
External validation study of a clinical decision aid to reduce unnecessary antibiotic prescriptions in women with acute cystitis. ( 28969592 )
2017
5
Does Staphylococcus Saprophyticus Cause Acute Cystitis only in Young Females, or is there more to the Story? A One-Year Comprehensive Study Done in Budapest, Hungary. ( 27020869 )
2016
6
Genotypic Characterization of Virulence Factors in Escherichia coli Isolated from Patients with Acute Cystitis, Pyelonephritis and Asymptomatic Bacteriuria. ( 28208853 )
2016
7
The efficacy of faropenem for patients with acute cystitis caused byA extended spectrum I^-lactamase producing Escherichia coli. ( 27916471 )
2016
8
Protein-based profiling of the immune response to uropathogenic Escherichia coli in adult patients immediately following hospital admission for acute cystitis. ( 27354295 )
2016
9
Molecular Basis of Acute Cystitis Reveals Susceptibility Genes and Immunotherapeutic Targets. ( 27732661 )
2016
10
Acute cystitis caused by commensal Neisseria oralis: A case report and review of the literature. ( 27889997 )
2016
11
The Acute Cystitis Symptom Score for Patient-Reported Outcome Assessment. ( 27591987 )
2016
12
Low Concordance With Guidelines for Treatment of Acute Cystitis in Primary Care. ( 26753168 )
2015
13
Outcome of nonadherence to antimicrobial treatment guidelines in ambulatory patients with acute cystitis: a nationwide population-based study. ( 25175125 )
2014
14
Re: voided midstream urine culture and acute cystitis in premenopausal women. ( 24745498 )
2014
15
Voided midstream urine culture is a good test for acute cystitis in premenopausal women. ( 24591543 )
2014
16
Role of special pathogenicity versus prevalence theory in pathogenesis of acute cystitis caused by Escherichia coli. ( 24899598 )
2014
17
New self-reporting questionnaire to assess urinary tract infections and differential diagnosis: acute cystitis symptom score. ( 24457349 )
2014
18
An unusual case of acute cystitis associated with mixed flora in voided urine in an adult male. ( 24153123 )
2014
19
Risk factors for recurrent cystitis following acute cystitis in female patients. ( 23380970 )
2013
20
Treatment of acute cystitis in Hungary: comparison with national guidelines and with disease-specific quality indicators. ( 23547569 )
2013
21
Voided midstream urine culture and acute cystitis in premenopausal women. ( 24224622 )
2013
22
Antibiotic-resistant Escherichia coli in women with acute cystitis in Canada. ( 24421825 )
2013
23
Genotypic characteristics and biofilm formation among Escherichia coli isolates from Indian women with acute cystitis. ( 23296752 )
2013
24
Do Escherichia coli strains causing acute cystitis have a distinct virulence repertoire? ( 22023989 )
2012
25
Urinary tract analgesics for the treatment of patients with acute cystitis: where is the clinical evidence? ( 23030327 )
2012
26
Treating acute cystitis with biodegradable micelle-encapsulated quercetin. ( 22661886 )
2012
27
Urinary MMP-9/NGAL complex in children with acute cystitis. ( 21556719 )
2011
28
Overestimation error and unnecessary antibiotic prescriptions for acute cystitis in adult women. ( 21191120 )
2011
29
Cytokines in urine in elderly subjects with acute cystitis and asymptomatic bacteriuria. ( 19247873 )
2009
30
Pivmecillinam versus sulfamethizole for short-term treatment of uncomplicated acute cystitis in general practice: a randomized controlled trial. ( 18991182 )
2009
31
Multidrug-resistant Escherichia fergusonii: a case of acute cystitis. ( 18256229 )
2008
32
Relationship between Escherichia coli strains causing acute cystitis in women and the fecal E. coli population of the host. ( 18495863 )
2008
33
LeuX tRNA-dependent and -independent mechanisms of Escherichia coli pathogenesis in acute cystitis. ( 18036139 )
2008
34
Ciprofloxacin and furagin in acute cystitis: comparison of early immune and microbiological results. ( 18060746 )
2008
35
Acute cystitis in women: experience with a telephone-based algorithm. ( 17970014 )
2007
36
Validation of a decision aid to assist physicians in reducing unnecessary antibiotic drug use for acute cystitis. ( 17998492 )
2007
37
Sharing of virulent Escherichia coli clones among household members of a woman with acute cystitis. ( 17051483 )
2006
38
Choice of antibiotic for empirical therapy of acute cystitis in a setting of high antimicrobial resistance. ( 16505574 )
2006
39
Outcomes of a pharmacoepidemiological survey on the antibiotic treatment of uncomplicated acute cystitis in community. ( 16330217 )
2006
40
Women's quality of life is decreased by acute cystitis and antibiotic adverse effects associated with treatment. ( 16048650 )
2005
41
Bacterial characteristics in relation to clinical source of Escherichia coli isolates from women with acute cystitis or pyelonephritis and uninfected women. ( 16333100 )
2005
42
Virulence characteristics of Escherichia coli strains causing acute cystitis in young adults in Iran. ( 15845429 )
2005
43
A 'gap' between physician and patient assessment of symptom severity in acute cystitis?: a multicenter trial of women treated with extended-release ciprofloxacin. ( 19667683 )
2004
44
Managing acute cystitis in women. ( 15020396 )
2004
45
Managing acute cystitis in women--are we mistreating? ( 12876128 )
2003
46
Cefpodoxime-proxetil versus trimethoprim-sulfamethoxazole for short-term therapy of uncomplicated acute cystitis in women. ( 12604518 )
2003
47
Antibiotic treatment for five days is effective in children with acute cystitis. ( 12641137 )
2003
48
Empirical treatment of acute cystitis in women. ( 12842322 )
2003
49
The impact of empirical management of acute cystitis on unnecessary antibiotic use. ( 12356077 )
2002
50
The impact of empirical management of acute cystitis on unnecessary antibiotic use. ( 11871930 )
2002

Variations for Acute Cystitis

Expression for Acute Cystitis

Search GEO for disease gene expression data for Acute Cystitis.

Pathways for Acute Cystitis

Pathways related to Acute Cystitis according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.82 CCL2 CXCL1 CXCL8 IL18 IL6 MCU
2
Show member pathways
12.43 CCL2 CXCL1 IL18 IL6
3
Show member pathways
12.17 ALB CCL2 CRP IL6
4
Show member pathways
12.16 CCL2 CXCL1 CXCL8 IL6
5
Show member pathways
11.83 CCL2 CXCL1 CXCL8
6 11.81 CCL2 CXCL1 CXCL8 IL6
7 11.79 CCL2 CXCL1 IL6
8 11.78 CXCL1 CXCL8 IL6
9 11.76 CCL2 CXCL8 IL18 IL6
10 11.74 CCL2 CXCL8 IL6
11 11.72 CXCL1 CXCL8 IL6
12
Show member pathways
11.69 CXCL1 CXCL8 IL6
13 11.6 CXCL1 CXCL8 IL18 IL6
14 11.49 CCL2 CXCL8 IL6
15 11.33 CCL2 IL18 KLK3
16 11.31 CCL2 CXCL1 CXCL8 IL18 IL6
17 11.3 CXCL1 CXCL8 IL18 IL6
18 11.16 CCL2 CXCL8 IL6
19 11.15 CCL2 CXCL8 IL18 IL6
20 10.78 CRP CXCL8 IL6
21 10.71 CCL2 CXCL1 CXCL8 IL18 IL6

GO Terms for Acute Cystitis

Cellular components related to Acute Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 ALB CCL2 CRP CXCL1 CXCL8 IL18
2 extracellular space GO:0005615 9.23 ALB CCL2 CRP CXCL1 CXCL8 IL18

Biological processes related to Acute Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.72 CCL2 CXCL1 CXCL8 IL18 IL6
2 regulation of signaling receptor activity GO:0010469 9.65 CCL2 CXCL1 CXCL8 IL18 IL6
3 cytokine-mediated signaling pathway GO:0019221 9.55 CCL2 CXCL1 CXCL8 IL18 IL6
4 chemokine-mediated signaling pathway GO:0070098 9.54 CCL2 CXCL1 CXCL8
5 PERK-mediated unfolded protein response GO:0036499 9.46 CCL2 CXCL8
6 neutrophil activation GO:0042119 9.43 CXCL8 IL18
7 negative regulation of lipid storage GO:0010888 9.4 CRP IL6
8 positive regulation of leukocyte chemotaxis GO:0002690 9.13 CXCL1 CXCL8 IL6
9 inflammatory response GO:0006954 9.1 CCL2 CRP CXCL1 CXCL8 IL18 IL6

Molecular functions related to Acute Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 CXCR chemokine receptor binding GO:0045236 9.16 CXCL1 CXCL8
2 chemokine activity GO:0008009 9.13 CCL2 CXCL1 CXCL8
3 cytokine activity GO:0005125 9.02 CCL2 CXCL1 CXCL8 IL18 IL6

Sources for Acute Cystitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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