MCID: ACT004
MIFTS: 39

Acute Diarrhea

Categories: Gastrointestinal diseases, Genetic diseases, Oral diseases, Rare diseases

Aliases & Classifications for Acute Diarrhea

MalaCards integrated aliases for Acute Diarrhea:

Name: Acute Diarrhea 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0050140
UMLS 74 C0740441

Summaries for Acute Diarrhea

Disease Ontology : 12 A diarrhea that is of rapid onset and course characterized by frequent loose or liquid bowel movements. Acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide.

MalaCards based summary : Acute Diarrhea is related to diarrhea and cholera, and has symptoms including diarrhea An important gene associated with Acute Diarrhea is PITX1 (Paired Like Homeodomain 1), and among its related pathways/superpathways is HIF Repressor Pathways. The drugs Zinc and Zinc sulfate have been mentioned in the context of this disorder. Affiliated tissues include small intestine, bone and prostate.

Wikipedia : 77 Gastroenteritis, also known as infectious diarrhea, is inflammation of the gastrointestinal tract—the... more...

Related Diseases for Acute Diarrhea

Graphical network of the top 20 diseases related to Acute Diarrhea:



Diseases related to Acute Diarrhea

Symptoms & Phenotypes for Acute Diarrhea

UMLS symptoms related to Acute Diarrhea:


diarrhea

Drugs & Therapeutics for Acute Diarrhea

Drugs for Acute Diarrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 87)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 7440-66-6 32051
2
Zinc sulfate Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 7733-02-0
3
Loperamide Approved Phase 4,Phase 3,Phase 1,Phase 2 53179-11-6 3955
4
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
5
tannic acid Approved Phase 4 1401-55-4
6
Simethicone Approved Phase 4,Phase 3 8050-81-5
7
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 447043
8
Glycine Approved, Nutraceutical, Vet_approved Phase 4 56-40-6 750
9
Racecadotril Investigational Phase 4,Phase 3,Phase 1,Not Applicable 81110-73-8
10 Thiorphan Experimental Phase 4,Phase 3,Phase 1 76721-89-6
11 Dermatologic Agents Phase 4,Phase 3,Phase 2,Not Applicable
12 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
13 Micronutrients Phase 4,Phase 3,Phase 2,Not Applicable
14 Astringents Phase 4,Phase 2,Phase 3,Not Applicable
15 Nutrients Phase 4,Phase 3,Phase 2,Not Applicable
16 Trace Elements Phase 4,Phase 3,Phase 2,Not Applicable
17 Acidophilus Phase 4,Phase 3,Phase 2,Not Applicable
18 Antidiarrheals Phase 4,Phase 3,Phase 1,Phase 2
19 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
20 Antioxidants Phase 4,Not Applicable
21 Chelating Agents Phase 4,Not Applicable
22
protease inhibitors Phase 4,Phase 3,Phase 1
23 HIV Protease Inhibitors Phase 4,Phase 3,Phase 1
24 Immunologic Factors Phase 4,Phase 1
25 Vaccines Phase 4
26 Emollients Phase 4,Phase 3
27 glutamine Phase 4,Phase 3
28 Cola Phase 4
29 Polyethylene glycol 3350 Phase 4
30 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable
31 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Not Applicable
32 Antibiotics, Antitubercular Phase 4,Phase 3,Not Applicable
33
Sulfasalazine Approved Phase 3 599-79-1 5353980 5359476
34
Octreotide Approved, Investigational Phase 3 83150-76-9 6400441 383414
35
Trimebutine Approved Phase 2, Phase 3 39133-31-8
36 Anti-Inflammatory Agents Phase 3
37 Peripheral Nervous System Agents Phase 3,Phase 2
38 Anti-Inflammatory Agents, Non-Steroidal Phase 3
39 Antirheumatic Agents Phase 3
40 Analgesics, Non-Narcotic Phase 3
41 Analgesics Phase 3
42 Antineoplastic Agents, Hormonal Phase 3
43 Antitubercular Agents Phase 3,Not Applicable
44 Anticoagulants Phase 3
45 Blood Substitutes Phase 3
46 Dextrans Phase 3
47 Plasma Substitutes Phase 3
48 Autonomic Agents Phase 2, Phase 3
49 Parasympatholytics Phase 2, Phase 3
50
Silicon Approved, Investigational Phase 2 7440-21-3 4082203

Interventional clinical trials:

(show top 50) (show all 86)
# Name Status NCT ID Phase Drugs
1 Oral Administration of Tannins and Flavonoids in Children With Acute Diarrhea Completed NCT03356327 Phase 4 Actitan F;Standard Oral Rehydration
2 Efficacy of Diosmectite (Smecta®) in the Symptomatic Treatment of Acute Diarrhoea in Adults Recruiting NCT02704091 Phase 4 Smecta;Smecta placebo
3 Efficacy of Use of Zinc in the Treatment of Acute Diarrhea in Infants Completed NCT01571856 Phase 4 Zinc Sulfate
4 Use of Probiotic Yogurt in the Treatment of Acute Diarrhea in Children Completed NCT01564290 Phase 4 Placebo probiotic
5 Effects of Probiotics and/or Prebiotics on the Duration of Diarrhea and Hospitalization in Children Completed NCT01927094 Phase 4
6 Oral Administration of Tannins and Flavonoids vs Sacchaomyces Boulardii in Pediatric Acute Diarrhea Not yet recruiting NCT03598010 Phase 4 Saccharomyces Boulardii 250 MG Oral Powder
7 Study to Evaluate Smecta® vs Placebo on the Time to Recovery Following an Acute Diarrhoea Episode in Adults Completed NCT00276328 Phase 4 Diosmectite (Smecta®)
8 Evaluation Of Bacillus Clausii In Treatment Of Acute Diarrhea In Latin American Children Completed NCT02169817 Phase 4 Bacillus clausii;Oral Rehydration Therapy
9 Zinc Sulphate vs. Zinc Amino Acid Chelate Completed NCT01791608 Phase 4
10 Efficacy of Racecadotril in Acute Watery Diarrhea in Children Completed NCT01577043 Phase 4 Racecadotril
11 Introduction of an Oral Live Human Rotavirus (Rotarix) Vaccine in Matlab Completed NCT00737503 Phase 4
12 A Comparison of Three Medications to Treat Diarrhea in Adults. Completed NCT00807326 Phase 4 Loperamide/simeticone 2 mg/125 mg caplets;Loperamide/simeticone 2 mg/125 mg chewable tablets;Probiotic Saccharomyces boulardii 250 mg capsules
13 Optimising Rotavirus Vaccine in Aboriginal Children Recruiting NCT02941107 Phase 4 Rotarix (RV1);Placebo
14 Prevention of Acute Radiation Enteritis With Glutamine Completed NCT00828399 Phase 4
15 The Treatment Effect of Bio-Three on Children With Enteritis Completed NCT01480947 Phase 4 Bio-three
16 Mode of Action of Moviprep Completed NCT01622972 Phase 4 Polyethyleneglycol
17 Azithromycin, With or Without Loperamide, to Treat Travelers' Diarrhea Completed NCT00359970 Phase 4 Azithromycin 500 mg;Azithromycin 1000 mg;Loperamide
18 Effectiveness of Oral Rehydration Therapy Supplemented With Zinc in the Management of Diarrhea Acute Unknown status NCT02601742 Phase 3
19 Randomized Controlled Field Trial of a Probiotics to Assess Its Role in Preventig Diarrhoea Unknown status NCT00534170 Phase 3
20 Oral Rehydration Solution With Zinc and Prebiotics in Acute Diarrhea Completed NCT01025583 Phase 2, Phase 3
21 Safety, Efficacy and Cost-effectiveness of Racecadotril in Children With Acute Diarrhea in Mexico Completed NCT01153854 Phase 3 Racecadotril;Placebo groups
22 Efficacy of Zinc Therapy in Acute Diarrhoea in Young Children Completed NCT00325247 Phase 3 ZINC
23 Study to Evaluate the Efficacy and Safety of Racecadotril in Children Aged 3 to 60 Months Suffering From Acute Diarrhea Recruiting NCT03473561 Phase 3 Racecadotril plus ORS
24 Controlled Study to Evaluate the Efficacy and Safety of Racecadotril in Infants, Children and Adolescents With Acute Diarrhea Completed NCT03463512 Phase 3 Racecadotril plus ORS;ORS
25 Efficacy and Safety Study of Loperamide Hydrochloride/Simethicone Chewable Tablet in Treatment of Acute Diarrhea With Abdominal Discomfort and Flatulence Completed NCT02340481 Phase 3 Loperamide hydrochloride + simethicone chewable tablet;Loperamide hydrochloride;Loperamide hydrochloride + simethicone chewable placebo tablet;Loperamide hydrochloride placebo capsule
26 Glutamine in Preventing Acute Diarrhea in Patients With Pelvic Cancer Completed NCT00003170 Phase 3
27 Sulfasalazine in Preventing Acute Diarrhea in Patients With Cancer Who Are Undergoing Pelvic Radiation Therapy Completed NCT01198145 Phase 3 sulfasalazine
28 TEDDY: Spores of Bacillus Clausii in Acute Diarrhoea in Children Completed NCT00265369 Phase 3 Spores of Bacillus Clausii Probiotic Strain
29 Zinc-ORS in Severe and Complicated Acute Diarrhea Completed NCT00370968 Phase 2, Phase 3 Zinc sulphate
30 Impact of Home Zinc Treatment for Acute Diarrhea in Children Completed NCT00530829 Phase 3 zinc
31 Effectiveness of Smecta in the Treatment of Acute Diarrhoea in Children Completed NCT00352716 Phase 3 Smecta (Diosmectite), duration of treatment - 7 days
32 ENterogermina® (Bacillus Clausii) In the manaGeMent of diarrheA in Children Completed NCT00457353 Phase 3 Bacillus Clausii
33 Octreotide in Preventing Diarrhea in Patients Who Are Undergoing Radiation Therapy to the Pelvis Completed NCT00033605 Phase 3 octreotide acetate
34 Antibiotics for Children With Severe Diarrhoea Recruiting NCT03130114 Phase 3 Azithromycin
35 Effectiveness of Smecta in Combination With Oral Rehydration in the Treatment of Acute Watery Diarrhoea in Infants and Children Completed NCT00352989 Phase 3 Smecta (Diosmectite), duration of treatment - 7 days
36 Gelatin Tannate as Treatment for Acute Childhood Gastroenteritis Completed NCT02644200 Phase 3
37 Impact of Bacillus Clausii Administration on Irritable Bowel Syndrome Patients Completed NCT03359499 Phase 2, Phase 3 Bacillus clausii;Trimebutine
38 Immunological and Clinical Responses to Zinc in Children With Diarrhoea Completed NCT00408356 Phase 3 Zinc
39 L Reuteri for the Prevention of Nosocomial Diarrhea Completed NCT01046656 Phase 3
40 Comparing the Efficacy of Two Oral Rehydration Solutions, With or Without the Probiotic Lactobacillus Reuteri DSM 17938 and Zinc, on the Duration and Severity of Acute Gastroenteritis in 6 - 36 Months Old Children in Out-patient Care Terminated NCT01737086 Phase 2, Phase 3
41 Zinc Supplementation in Cholera Patients Completed NCT00226616 Phase 3 Zinc
42 Efficacy of Zinc Sulfate With Probiotics for the Treatment of Acute Diarrhea in Children Unknown status NCT01140074 Phase 2 Zinc Sulfate
43 Influence of Carob and Probiotics on Acute Diarrhea in Children Unknown status NCT01501305 Phase 1, Phase 2
44 Early Administration of Lactose-free Milk in Children Presenting With Acute Diarrhea Completed NCT01269892 Phase 2
45 Efficacy of the Administration of Colloidal Silicon Dioxide in Tablet Dosage Form in Patients With Acute Diarrhea Completed NCT03633344 Phase 2 Carbowhite;Carbowhite placebo
46 Isoleucine Added ORS in Children With Diarrhoea Completed NCT01034228 Phase 2
47 Modified ORS Solution for Severely Malnourished Children Completed NCT01821586 Phase 2
48 Acceptability and Effectiveness of Household Water Treatment in Reducing Diarrhea Among Under Five Children Completed NCT01376440 Phase 1
49 Study to Compare the Pharmacokinetics Profiles of Four Racecadotril Products Completed NCT01476683 Phase 1 Racecadotril;Racecadotril;Racecadotril;Racecadotril
50 Bioequivalence Between a Racecadotril Capsule and Film-Coated Tablet (FCT) to Treat Diarrhea in Adults Completed NCT01302093 Phase 1 Racecadotril Film-Coated Tablet (FCT);Racecadotril Capsule

Search NIH Clinical Center for Acute Diarrhea

Genetic Tests for Acute Diarrhea

Anatomical Context for Acute Diarrhea

MalaCards organs/tissues related to Acute Diarrhea:

42
Small Intestine, Bone, Prostate, Breast, Testes, Lymph Node, T Cells

Publications for Acute Diarrhea

Articles related to Acute Diarrhea:

(show top 50) (show all 672)
# Title Authors Year
1
Industry funding effect on positive results of probiotic use in the management of acute diarrhea: a systematized review. ( 30557228 )
2019
2
Outcomes and clinical relevance of stool multiplex bacterial polymerase chain reaction in patients with acute diarrhea: single center experience. ( 30685964 )
2019
3
Plasma citrulline, arginine, nitric oxide, and blood ammonia levels in neonatal calves with acute diarrhea. ( 30788867 )
2019
4
Efficacy of an orally administered anti-diarrheal probiotic paste (Pro-Kolin Advanced) in dogs with acute diarrhea: A randomized, placebo-controlled, double-blinded clinical study. ( 30882953 )
2019
5
Hemorrhagic Fever with Renal Syndrome as a Cause of Acute Diarrhea. ( 30915955 )
2019
6
Acute Diarrhea in an Immunocompromised 55-year-old Man. ( 29549045 )
2018
7
Therapeutic Efficacy of Bumped Kinase Inhibitor 1369 in a Pig Model of Acute Diarrhea Caused by Cryptosporidium hominis. ( 29661877 )
2018
8
Molecular detection and phylogenetic analysis of human parechovirus in individuals with acute diarrhea and healthy controls in Guangzhou, China. ( 29738080 )
2018
9
Universal recommendations for the management of acute diarrhea in non-malnourished children. ( 29901556 )
2018
10
Incidence of Acute Diarrhea-Associated Death among Children < 5 Years of Age in Bangladesh, 2010-12. ( 29141756 )
2018
11
Epidemiology of acute diarrhea caused by rotavirus in sentinel surveillance sites of Vietnam, 2012-2015. ( 29784467 )
2018
12
Cost utility, budget impact, and scenario analysis of racecadotril in addition to oral rehydration for acute diarrhea in children in Malaysia. ( 29588606 )
2018
13
Racecadotril in the treatment of acute diarrhea in children: a systematic, comprehensive review and meta-analysis of randomized controlled trials. ( 29614995 )
2018
14
Development of a real time reverse transcription loop-mediated isothermal amplification method (RT-LAMP) for detection of a novel swine acute diarrhea syndrome Coronavirus (SADS-CoV). ( 29936095 )
2018
15
Characteristics of diarrheagenic Escherichia coli among children under 5 years of age with acute diarrhea: a hospital based study. ( 29390982 )
2018
16
Bangladeshi children with acute diarrhea show fecal microbiomes with increased Streptococcus abundance, irrespective of diarrhea etiology. ( 29786169 )
2018
17
Diagnosis and Treatment of Undifferentiated and Infectious Acute Diarrhea in the Adult Horse. ( 29426709 )
2018
18
Oral administration of tannins and flavonoids in children with acute diarrhea: a pilot, randomized, control-case study. ( 29866147 )
2018
19
Prescription of medications for acute diarrhea in infants in Antananarivo, Madagascar. ( 29997077 )
2018
20
Prevalence of rotavirus and rapid changes in circulating rotavirus strains among children with acute diarrhea in China, 2009-2015. ( 30017609 )
2018
21
The piglet acute diarrhea model for evaluating efficacy of treatment and control of cryptosporidiosis. ( 30036127 )
2018
22
Extended-spectrum β-lactamase prevalence and virulence factor characterization of enterotoxigenic Escherichia coli responsible for acute diarrhea in Nepal from 2001 to 2016. ( 30038780 )
2018
23
Bacillus clausii for the Treatment of Acute Diarrhea in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. ( 30103531 )
2018
24
Prevalence and antimicrobial resistance of shiga toxin-producing Escherichia coli and enteropathogenic Escherichia coli isolated from patients with acute diarrhea. ( 30112152 )
2018
25
Adenovirus associated with acute diarrhea: a case-control study. ( 30176819 )
2018
26
A prospective, interventional, randomized, double-blind, placebo-controlled clinical study to evaluate the efficacy and safety of Bacillus coagulans LBSC in the treatment of acute diarrhea with abdominal discomfort. ( 30264164 )
2018
27
Ultrasound Adds No Benefit to Clinical Exam for Predicting Dehydration in Children With Acute Diarrhea in a Resource-Limited Setting. ( 30291639 )
2018
28
Epidemiologic and Genotypic distribution of Noroviruses among children with Acute Diarrhea and Healthy Controls in a Low-income Rural Setting. ( 30351379 )
2018
29
Household-stored drinking water quality among households of under-five children with and without acute diarrhea in towns of Wegera District, in North Gondar, Northwest Ethiopia. ( 30353421 )
2018
30
Efficacy of gelatin tannate for acute diarrhea in children: a systematic review and meta-analysis. ( 30465439 )
2018
31
Pediatric Tui Na for acute diarrhea in children under 5 years old: A systematic review and meta-analysis of randomized clinical trials. ( 30477824 )
2018
32
Comparative effectiveness and safety of interventions for acute diarrhea and gastroenteritis in children: A systematic review and network meta-analysis. ( 30517196 )
2018
33
Complete Genome Sequence of a Novel Swine Acute Diarrhea Syndrome Coronavirus, CH/FJWT/2018, Isolated in Fujian, China, in 2018. ( 30533848 )
2018
34
Development of a SYBR green-based real-time RT-PCR assay for rapid detection of the emerging swine acute diarrhea syndrome coronavirus. ( 30593837 )
2018
35
Retrospective detection and phylogenetic analysis of swine acute diarrhea syndrome coronavirus in pigs in southern China. ( 30171801 )
2018
36
Evaluation of Gelatin Tannate Against Symptoms of Acute Diarrhea in Pediatric Patients. ( 28448477 )
2017
37
Prospective study on the overuse of blood test-guided antibiotics on patients with acute diarrhea in primary hospitals of China. ( 28352160 )
2017
38
Etiology of acute diarrhea in the elderly in China: A six-year observational study. ( 28323855 )
2017
39
Discovery and characterization of an escherichia coli ST206 strain producing NDM-5 and MCR-1 from a patient with acute diarrhea. ( 28919194 )
2017
40
Correlates of multi-drug non-susceptibility in enteric bacteria isolated from Kenyan children with acute diarrhea. ( 28968393 )
2017
41
Serum Zinc Levels as a Predictor of Severity of Acute Diarrhea. ( 29152688 )
2017
42
Detection and Molecular Characterization of Human Adenovirus Infections among Hospitalized Children with Acute Diarrhea in Shanghai, China, 2006-2011. ( 29445406 )
2017
43
High prevalence of GII norovirus in hospitalized children with acute diarrhea, in Beijing. ( 28662103 )
2017
44
The Most Important Recommended Times of Hand Washing with Soap and Water in Preventing the Occurrence of Acute Diarrhea Among Children Under Five Years of Age in Slums of Addis Ababa, Ethiopia. ( 29138957 )
2017
45
Rapid Clearance and Frequent Reinfection With Enteric Pathogens Among Children With Acute Diarrhea in Zanzibar. ( 29017253 )
2017
46
A cross-sectional study of acute diarrhea in Pudong, Shanghai, China: prevalence, risk factors, and healthcare-seeking practices. ( 28830575 )
2017
47
Evaluation of water and electrolytes disorders in severe acute diarrhea patients treated by WHO protocol in eight large hospitals in Tehran; a nephrology viewpoint. ( 28497085 )
2017
48
Molecular Analysis of the Enteric Protozoa Associated with Acute Diarrhea in Hospitalized Children. ( 28824878 )
2017
49
Prevalence and determinants of acute diarrhea among children younger than five years old in Jabithennan District, Northwest Ethiopia, 2014. ( 28103908 )
2017
50
Utilization of health facilities and predictors of health-seeking behavior for under-five children with acute diarrhea in slums of Addis Ababa, Ethiopia: a community-based cross-sectional study. ( 28376916 )
2017

Variations for Acute Diarrhea

Expression for Acute Diarrhea

Search GEO for disease gene expression data for Acute Diarrhea.

Pathways for Acute Diarrhea

Pathways related to Acute Diarrhea according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.18 EPAS1 PKM

GO Terms for Acute Diarrhea

Biological processes related to Acute Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 iron ion homeostasis GO:0055072 9.16 EPAS1 LTF
2 response to gravity GO:0009629 8.96 PKM STX1A
3 myoblast fate commitment GO:0048625 8.62 EPAS1 PITX1

Sources for Acute Diarrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....