ADE
MCID: ACT049
MIFTS: 53

Acute Disseminated Encephalomyelitis (ADE)

Categories: Eye diseases, Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Acute Disseminated Encephalomyelitis

MalaCards integrated aliases for Acute Disseminated Encephalomyelitis:

Name: Acute Disseminated Encephalomyelitis 12 20 53 58 15 17
Acute Disseminated Encephalitis 12 58 70 32
Adem 12 20 58
Encephalomyelitis, Acute Disseminated 70
Encephalomyelitis Acute Disseminated 54
Ade 20

Characteristics:

Orphanet epidemiological data:

58
acute disseminated encephalomyelitis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare neurological diseases
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:639
MeSH 44 D004673
NCIt 50 C34578
SNOMED-CT 67 83942000
ICD10 32 G04.0
ICD10 via Orphanet 33 G04.0
UMLS via Orphanet 71 C0014059
Orphanet 58 ORPHA83597
UMLS 70 C0014059 C3536864

Summaries for Acute Disseminated Encephalomyelitis

NINDS : 53 Acute disseminated encephalomyelitis (ADEM) is characterized by a brief but widespread attack of inflammation in the brain and spinal cord that damages myelin – the protective covering of nerve fibers.  ADEM often follows viral or bacterial infections, or less often, vaccination for measles, mumps, or rubella.  The symptoms of ADEM appear rapidly, beginning with encephalitis-like symptoms such as fever, fatigue, headache, nausea and vomiting, and in the most severe cases, seizures and coma.  ADEM typically damages white matter (brain tissue that takes its name from the white color of myelin), leading to neurological symptoms such as visual loss (due to inflammation of the optic nerve) in one or both eyes, weakness even to the point of paralysis, and difficulty coordinating voluntary muscle movements (such as those used in walking).  ADEM is sometimes misdiagnosed as a severe first attack of multiple sclerosis (MS), since the symptoms and the appearance of the white matter injury on brain imaging may be similar.  However, ADEM has several features which differentiate it from MS.  First, unlike MS patients, persons with ADEM will have rapid onset of fever, a history of recent infection or immunization, and some degree of impairment of consciousness, perhaps even coma; these features are not typically seen in MS.  Children are more likely than adults to have ADEM, whereas MS is a rare diagnosis in children.  In addition, ADEM usually consists of a single episode or attack of widespread myelin damage, while MS features many attacks over the course of time. Doctors will often use imaging techniques, such as MRI (magnetic resonance imaging), to search for old and new lesions (areas of damage) on the brain.  The presence of older brain lesions on MRI suggest that the condition may be MS rather than ADEM, since MS can cause brain lesions before symptoms become obvious.  In rare situations, a brain biopsy may be necessary to differentiate between ADEM and some other diseases that involve inflammation and damage to myelin.

MalaCards based summary : Acute Disseminated Encephalomyelitis, also known as acute disseminated encephalitis, is related to allergic encephalomyelitis and acute hemorrhagic leukoencephalitis. An important gene associated with Acute Disseminated Encephalomyelitis is MBP (Myelin Basic Protein), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Actin Nucleation by ARP-WASP Complex. The drugs Vaccines and Antibodies, Blocking have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and eye, and related phenotypes are seizures and neurological speech impairment

Disease Ontology : 12 An encephalomyelitis characterized by inflammation located in brain and located in spinal cord that damages myelin. It usually occurs after viral infection, but also following vaccination, bacterial or parasitic infection.

GARD : 20 Acute disseminated encephalomyelitis (ADEM) is a neurological condition characterized by a brief but intense attack of inflammation in the brain and spinal cord. This may lead to damage of the layer of insulation around the nerves ( myelin ) within affected areas. ADEM often follows viral infection, or less often, vaccinations for measles, mumps, or rubella (MMR). Symptoms usually appear rapidly, beginning with fever, fatigue, headache, nausea and vomiting. Treatment for ADEM is targeted at suppressing inflammation in the brain using anti-inflammatory drugs. Most people begin to recover within days, with total or near-total recovery within a few months. Some people may have lifelong neurological impairments, and very rarely, severe cases can be fatal.

Wikipedia : 73 Acute disseminated encephalomyelitis (ADEM), or acute demyelinating encephalomyelitis, is a rare... more...

Related Diseases for Acute Disseminated Encephalomyelitis

Diseases related to Acute Disseminated Encephalomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 558)
# Related Disease Score Top Affiliating Genes
1 allergic encephalomyelitis 32.4 MOG MBP
2 acute hemorrhagic leukoencephalitis 32.3 MBP CDH23 AQP4
3 subacute sclerosing panencephalitis 32.3 MOG MBP IL10
4 pediatric multiple sclerosis 31.5 MOG HLA-DRB1 HLA-DQB1
5 mumps 31.2 IL1B IL10 HLA-DRB1 HLA-DQB1
6 aseptic meningitis 31.0 IL1B IL10 CSF3
7 hypersomnia 30.9 HLA-DRB1 HLA-DQB1 HCRT
8 acute transverse myelitis 30.9 IL10 AQP4
9 meningoencephalitis 30.9 MBP IL1B IL10 CCR6
10 myelitis 30.9 MOG MBP IL10 CCR6 AQP4
11 lupus erythematosus 30.8 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1
12 rubella 30.7 MOG IL1B IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1
13 exanthem 30.7 IL1B IL10 CSF3 CCR6
14 transverse myelitis 30.7 MOG MBP IL10 CCR6 AQP4
15 brain edema 30.6 IL1B CSF3 AQP4
16 neuromyelitis optica 30.6 MOG MBP IL1B HLA-DRB1 HCRT AQP4
17 gastroenteritis 30.6 IL1B IL10 CSF3
18 bacterial meningitis 30.5 IL1B IL10 CCL4 AQP4
19 rheumatic fever 30.5 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1
20 demyelinating disease 30.5 MPZ MOG MBP IL1B IL10 HLA-DRB1
21 guillain-barre syndrome 30.5 MPZ MOG MBP HLA-DRB1 HLA-DQB1 HLA-DQA1
22 common cold 30.5 IL1B IL10 CCR6
23 toxoplasmosis 30.5 IL1B IL10 HLA-DQB1 HLA-DQA1
24 meningitis 30.5 IL1B IL10 HLA-B CSF3 CCL4 AQP4
25 central nervous system disease 30.5 MOG MBP IL1B CCR6
26 cerebritis 30.4 IL1B AQP4
27 optic neuritis 30.4 MPZ MOG MBP IL1B IL10 HLA-DRB1
28 pure red-cell aplasia 30.4 HLA-DRB1 HLA-DQB1 HLA-B
29 autoimmune encephalitis 30.4 LGI1 HCRT CNTNAP2
30 herpes zoster 30.4 IL10 HLA-DRB1 HLA-B CCR6
31 neuritis 30.4 MPZ MOG MBP IL1B IL10 HLA-DRB1
32 respiratory failure 30.4 IL1B IL10 HCRT CCR6
33 polyradiculoneuropathy 30.3 MPZ MBP IL10 CCL4
34 thyroiditis 30.3 IL1B IL10 HLA-DRB1
35 graft-versus-host disease 30.3 IL1B IL10 HLA-DRB1 HLA-DQB1 HLA-B
36 acute retrobulbar neuritis 30.3 MBP AQP4
37 central nervous system vasculitis 30.3 IL1B IL10 HLA-DRB1 CCR6
38 common variable immunodeficiency 30.3 IL1B IL10 HLA-DRB1 HLA-DQB1 HLA-B
39 balo concentric sclerosis 30.3 MOG MBP AQP4
40 internuclear ophthalmoplegia 30.3 MOG MBP AQP4
41 myocarditis 30.2 IL1B IL10 HLA-DQB1 HLA-B
42 myositis 30.2 IL1B HLA-DRB1 HLA-DQA1 HLA-B
43 chronic inflammatory demyelinating polyradiculoneuropathy 30.2 MPZ MBP IL10 HLA-DRB1 CCL4
44 postinfectious encephalitis 30.2 MBP LGI1 CNTNAP2
45 streptococcus pneumonia 30.2 IL1B IL10 CCR6
46 polyradiculopathy 30.2 MBP LGI1
47 nervous system disease 30.1 MOG MBP IL1B IL10 CCR6 AQP4
48 mutism 30.1 PNMA2 LGI1 CNTNAP2
49 typhoid fever 30.1 IL1B HLA-DRB1 HLA-DQB1 CCR6
50 viral encephalitis 30.1 MOG MBP LGI1 IL1B IL10 CCR6

Graphical network of the top 20 diseases related to Acute Disseminated Encephalomyelitis:



Diseases related to Acute Disseminated Encephalomyelitis

Symptoms & Phenotypes for Acute Disseminated Encephalomyelitis

Human phenotypes related to Acute Disseminated Encephalomyelitis:

58 (show top 50) (show all 53)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 seizures 58 Frequent (79-30%)
2 neurological speech impairment 58 Occasional (29-5%)
3 abnormal pyramidal sign 58 Frequent (79-30%)
4 ataxia 58 Frequent (79-30%)
5 muscle weakness 58 Occasional (29-5%)
6 behavioral abnormality 58 Frequent (79-30%)
7 vomiting 58 Occasional (29-5%)
8 fever 58 Frequent (79-30%)
9 cranial nerve paralysis 58 Occasional (29-5%)
10 irritability 58 Frequent (79-30%)
11 involuntary movements 58 Very rare (<4-1%)
12 mental deterioration 58 Frequent (79-30%)
13 headache 58 Frequent (79-30%)
14 abnormal cerebellum morphology 58 Frequent (79-30%)
15 diaphragmatic paralysis 58 Very rare (<4-1%)
16 encephalopathy 58 Obligate (100%)
17 respiratory failure requiring assisted ventilation 58 Occasional (29-5%)
18 hypersomnia 58 Frequent (79-30%)
19 coma 58 Occasional (29-5%)
20 hemiparesis 58 Occasional (29-5%)
21 sensory impairment 58 Occasional (29-5%)
22 aggressive behavior 58 Occasional (29-5%)
23 abnormality of the periventricular white matter 58 Frequent (79-30%)
24 optic neuritis 58 Occasional (29-5%)
25 confusion 58 Occasional (29-5%)
26 visual loss 58 Occasional (29-5%)
27 abnormality of the spinal cord 58 Frequent (79-30%)
28 abnormal thalamic mri signal intensity 58 Frequent (79-30%)
29 abnormality of the basal ganglia 58 Frequent (79-30%)
30 viral hepatitis 58 Very rare (<4-1%)
31 diffuse white matter abnormalities 58 Very frequent (99-80%)
32 cerebral edema 58 Frequent (79-30%)
33 abnormal brainstem mri signal intensity 58 Frequent (79-30%)
34 nausea 58 Frequent (79-30%)
35 eeg with generalized slow activity 58 Very frequent (99-80%)
36 increased csf protein 58 Frequent (79-30%)
37 cns demyelination 58 Very frequent (99-80%)
38 hypointensity of cerebral white matter on mri 58 Very rare (<4-1%)
39 myelitis 58 Frequent (79-30%)
40 csf lymphocytic pleiocytosis 58 Frequent (79-30%)
41 obtundation status 58 Occasional (29-5%)
42 eeg with focal spikes 58 Occasional (29-5%)
43 nuchal rigidity 58 Occasional (29-5%)
44 disseminated viral infection 58 Frequent (79-30%)
45 severe epstein barr virus infection 58 Very rare (<4-1%)
46 interictal eeg abnormality 58 Frequent (79-30%)
47 anti-myelin oligodendrocyte glycoprotein antibody positivity 58 Frequent (79-30%)
48 eeg with focal slow activity 58 Occasional (29-5%)
49 eye movement-induced pain 58 Occasional (29-5%)
50 herpes simplex encephalitis 58 Very rare (<4-1%)

MGI Mouse Phenotypes related to Acute Disseminated Encephalomyelitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.73 AQP4 CCR6 CDH23 CSF3 HLA-DQA1 HLA-DQB1
2 nervous system MP:0003631 9.44 AQP4 CCR6 CDH23 CNTNAP2 HCRT HLA-DQB1

Drugs & Therapeutics for Acute Disseminated Encephalomyelitis

Drugs for Acute Disseminated Encephalomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4
2 Antibodies, Blocking Phase 4
3
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
4
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
5
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
6
Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
7
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
8
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
9 Methylprednisolone Acetate Phase 3
10 Immunoglobulins
11 Antibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Neutralizing Antibody Titers 6 Years After the Third Dose of Inactivated Japanese Encephalitis Vaccine and Projected Duration of Protection Completed NCT02039440 Phase 4
2 Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone Unknown status NCT00004645 Phase 3
3 Management of Acute Disseminated Encephalomyelitis in Neurology Unit of Assiut University Children Hospital Unknown status NCT03284801
4 PEDIATRIC SONICS: Pediatric Study of Neuropsychology and Imaging in CNS Demyelinating Syndromes. Recruiting NCT03942952
5 Large-scale, Multi-disciplinary Sample and Data Repository for Multiple Sclerosis and Related Demyelinating Diseases Active, not recruiting NCT00445367

Search NIH Clinical Center for Acute Disseminated Encephalomyelitis

Genetic Tests for Acute Disseminated Encephalomyelitis

Anatomical Context for Acute Disseminated Encephalomyelitis

MalaCards organs/tissues related to Acute Disseminated Encephalomyelitis:

40
Brain, Spinal Cord, Eye, Myeloid, Skin, Cerebellum, Bone Marrow

Publications for Acute Disseminated Encephalomyelitis

Articles related to Acute Disseminated Encephalomyelitis:

(show top 50) (show all 1795)
# Title Authors PMID Year
1
Doxycycline in autoimmune central nervous system disorders in children: an in vitro study. 54 61
17990580 2007
2
Hypersomnia and low cerebrospinal fluid hypocretin levels in acute disseminated encephalomyelitis. 54 61
15519122 2004
3
Structural similarity between the bee venom peptides and the immunodominant human myelin basic proteins: role for pathogenesis of acute disseminated encephalomyelitis. 54 61
12589368 2003
4
A case of acute disseminated encephalomyelitis presenting hypersomnia with decreased hypocretin level in cerebrospinal fluid. 54 61
12269735 2002
5
Heat shock protein immunoreactivity in CSF: correlation with oligoclonal banding and demyelinating disease. 61 54
7936289 1994
6
Potential Role of CHI3L1+ Astrocytes in Progression in MS. 61
33658322 2021
7
Cerebrospinal fluid metabolites in tryptophan-kynurenine and nitric oxide pathways: biomarkers for acute neuroinflammation. 61
33336374 2021
8
Coronavirus Infections in the Nervous System of Children: A Scoping Review Making the Case for Long-Term Neurodevelopmental Surveillance. 61
33676141 2021
9
MOGAD: How It Differs From and Resembles Other Neuroinflammatory Disorders. 61
32755221 2021
10
Pediatric inflammatory demyelinating disorders and mimickers: How to differentiate with MRI? 61
33727154 2021
11
Clinical Features, Treatment Strategies, and Outcomes in Hospitalized Children With Immune-Mediated Encephalopathies. 61
33388545 2021
12
Incidence and Mortality of Acute Disseminated Encephalomyelitis in China: A Nationwide Population-Based Study. 61
33675527 2021
13
[Tumefactive demyelinating lesion (TDL)]. 61
33762460 2021
14
Estimating Baseline Incidence of Conditions Potentially Associated with Vaccine Adverse Events: a Call for Surveillance System Using the Korean National Health Insurance Claims Data. 61
33686812 2021
15
Myelin oligodendrocyte glycoprotein antibody-associated disorders: clinical spectrum, diagnostic evaluation, and treatment options. 61
32403899 2021
16
Myelin oligodendrocyte glycoprotein-IgG-positive, steroid-responsive combined central and peripheral demyelination with recurrent peripheral neuropathy. 61
33078247 2021
17
Non-Polio Enteroviruses from Acute Flaccid Paralysis Surveillance in Korea, 2012-2019. 61
33807557 2021
18
Neurological Involvements of SARS-CoV2 Infection. 61
33064267 2021
19
Neuroimaging manifestations in children with SARS-CoV-2 infection: a multinational, multicentre collaborative study. 61
33338439 2021
20
Hospital-diagnosed infections before age 20 and risk of a subsequent multiple sclerosis diagnosis. 61
33693538 2021
21
Investigating Different Forms of Hydrogen Sulfide in Cerebrospinal Fluid of Various Neurological Disorders. 61
33800163 2021
22
Incidence Rates of Autoimmune Diseases in European Healthcare Databases: A Contribution of the ADVANCE Project. 61
33462778 2021
23
[Neuroimmunology of COVID-19]. 61
33651117 2021
24
Spinal cord involvement in COVID-19: A review. 61
33705268 2021
25
Association of COVID-19 and Acute Disseminated Encephalomyelitis (ADEM) in the absence of pulmonary involvement. 61
33476819 2021
26
Post-COVID-19 Acute Disseminated Encephalomyelitis in a 17-month-old. 61
33762311 2021
27
Acute disseminated encephalomyelitis after severe acute respiratory syndrome coronavirus 2 vaccination: a case report. 61
33527327 2021
28
Acute Disseminated Encephalomyelitis (ADEM): A Demyelinating Disease with Specific Morphological Features. 61
33616454 2021
29
Neuroimaging and neurologic findings in COVID-19 and other coronavirus infections: A systematic review in 116 patients. 61
32603770 2021
30
COVID-19-related intracranial imaging findings: a large single-centre experience. 61
33023738 2021
31
Association between Optic Neuritis and Inflammatory Bowel Disease: A Population-Based Study. 61
33578895 2021
32
Atypical Presentation of Fulminating Subacute Sclerosing Panencephalitis: A Case Series. 61
33065753 2021
33
Acute hemorrhagic leukoencephalitis in a COVID-19 patient-a case report with literature review. 61
33575849 2021
34
Late-onset MADD in Yemen caused by a novel ETFDH mutation misdiagnosed as ADEM. 61
33383363 2021
35
Epidemiology of Demyelinating Diseases in Korean Pediatric Patients. 61
32988277 2021
36
[Acute lymphocytic leukemia with cytomegalovirus associated acute disseminated encephalomyelitis]. 61
33548961 2021
37
Clinical spectrum, treatment and outcome of myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease in children: a tertiary care experience. 61
33231843 2021
38
Neuropsychological Phenotypes of Pediatric Anti-Myelin Oligodendrocyte Glycoprotein Associated Disorders: A Case Series. 61
33578444 2021
39
Neuroimaging Findings in Rabies Encephalitis. 61
33534937 2021
40
Decompressive craniectomy as a lifesaving intervention for acute disseminated encephalomyelitis (ADEM). 61
33161197 2021
41
Leptospira Triggered Anti-N-Methyl-d-Aspartate Receptor Encephalitis. 61
33089323 2021
42
Acute disseminated encephalomyelitis after SARS-CoV-2 infection. 61
33323467 2021
43
Teaching Neuroimages: COVID-19-Associated Acute Disseminated Encephalomyelitis With Corpus Callosal Hemorrhage. 61
33055272 2021
44
Clinical Features and Risk of Relapse in Children and Adults with Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease. 61
32959427 2021
45
"FLAMES: A novel burning entity in MOG IgG associated disease". 61
33508569 2021
46
Complete Oculomotor Palsy after Influenza Vaccination in a Young Healthy Adult: A Case Report. 61
33613242 2021
47
Acute Disseminated Encephalomyelitis Related to a Cytomegalovirus Infection in an Immunocompetent Patient. 61
33628664 2021
48
Severe Measles Encephalitis and Acute Disseminated Encephalomyelitis in an Immunocompetent Japanese Young Male. 61
33456033 2021
49
Spectrum of neuroimaging findings in COVID-19. 61
33305996 2021
50
Neuropathology of COVID-19 (neuro-COVID): clinicopathological update. 61
33554218 2021

Variations for Acute Disseminated Encephalomyelitis

Expression for Acute Disseminated Encephalomyelitis

Search GEO for disease gene expression data for Acute Disseminated Encephalomyelitis.

Pathways for Acute Disseminated Encephalomyelitis

Pathways related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.29 IL1B IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
2
Show member pathways
12.88 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B
3
Show member pathways
12.78 IL1B HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B
4 12.76 IL1B HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B
5
Show member pathways
12.6 IL1B IL10 HSPD1 HLA-DRB1 HLA-DQB1 HLA-DQA1
6
Show member pathways
12.58 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
7
Show member pathways
12.55 IL1B IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
8
Show member pathways
12.49 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B
9
Show member pathways
12.32 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
10 12.3 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B
11
Show member pathways
12.28 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
12
Show member pathways
12.16 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
13 12.12 IL1B IL10 HSPD1 AQP4
14 12.09 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B
15
Show member pathways
12.08 IL1B IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
16
Show member pathways
11.91 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
17 11.88 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
18 11.87 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 CDH23
19 11.81 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
20 11.77 IL1B HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
21 11.76 IL1B IL10 HSPD1 HLA-DRB1 HLA-DQB1 HLA-DQA1
22 11.72 IL1B IL10 CCR6
23
Show member pathways
11.72 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
24 11.7 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
25 11.63 IL1B HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 CSF3
26 11.6 IL1B CSF3 CCL4
27 11.49 IL1B IL10 CSF3
28 11.47 IL1B IL10 CSF3 CCL4
29 11.34 MPZ HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B
30 11.13 IL1B IL10 HLA-DRB1 CSF3

GO Terms for Acute Disseminated Encephalomyelitis

Cellular components related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.95 MBP HSPD1 HLA-DRB1 HLA-DPA1 HLA-B CNTNAP2
2 lysosome GO:0005764 9.91 MPZ IL1B HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
3 endosome membrane GO:0010008 9.88 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 AQP4
4 trans-Golgi network membrane GO:0032588 9.76 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
5 rough endoplasmic reticulum GO:0005791 9.67 MPZ HSPD1 HCRT
6 endocytic vesicle membrane GO:0030666 9.67 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
7 transport vesicle membrane GO:0030658 9.62 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
8 clathrin-coated endocytic vesicle membrane GO:0030669 9.56 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
9 MHC class II protein complex GO:0042613 9.46 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
10 ER to Golgi transport vesicle membrane GO:0012507 9.35 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B
11 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.02 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B

Biological processes related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 9.89 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B
2 cellular response to interferon-gamma GO:0071346 9.72 HLA-DPA1 CCL4 AQP4
3 T cell receptor signaling pathway GO:0050852 9.72 MOG HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
4 positive regulation of interleukin-6 production GO:0032755 9.71 MBP IL1B HSPD1
5 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.67 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
6 positive regulation of interferon-gamma production GO:0032729 9.65 IL1B HSPD1 HLA-DPA1
7 interferon-gamma-mediated signaling pathway GO:0060333 9.65 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B
8 detection of bacterium GO:0016045 9.52 HLA-DRB1 HLA-B
9 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.51 MBP IL10
10 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.46 HLA-DRB1 HLA-DQB1
11 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.46 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
12 positive regulation of T cell mediated immune response to tumor cell GO:0002842 9.43 HSPD1 HLA-DRB1
13 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.4 HLA-DRB1 HLA-DQB1
14 immune response GO:0006955 9.36 MBP IL1B IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1
15 antigen processing and presentation GO:0019882 9.35 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B

Molecular functions related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.46 IL1B IL10 CSF3 CCL4
2 MHC class II receptor activity GO:0032395 9.26 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
3 peptide antigen binding GO:0042605 9.02 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B

Sources for Acute Disseminated Encephalomyelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....