MCID: ACT049
MIFTS: 56

Acute Disseminated Encephalomyelitis

Categories: Eye diseases, Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Acute Disseminated Encephalomyelitis

MalaCards integrated aliases for Acute Disseminated Encephalomyelitis:

Name: Acute Disseminated Encephalomyelitis 12 54 55 60 15 17
Acute Disseminated Encephalitis 12 60 74
Adem 12 54 60
Encephalomyelitis, Acute Disseminated 74
Encephalomyelitis Acute Disseminated 56
Ade 54

Characteristics:

Orphanet epidemiological data:

60
acute disseminated encephalomyelitis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



External Ids:

Disease Ontology 12 DOID:639
MeSH 45 D004673
NCIt 51 C34578
SNOMED-CT 69 83942000
ICD10 34 G04.0
ICD10 via Orphanet 35 G04.0
UMLS via Orphanet 75 C0014059
Orphanet 60 ORPHA83597

Summaries for Acute Disseminated Encephalomyelitis

NINDS : 55 Acute disseminated encephalomyelitis (ADEM) is characterized by a brief but widespread attack of inflammation in the brain and spinal cord that damages myelin – the protective covering of nerve fibers.  ADEM often follows viral or bacterial infections, or less often, vaccination for measles, mumps, or rubella.  The symptoms of ADEM appear rapidly, beginning with encephalitis-like symptoms such as fever, fatigue, headache, nausea and vomiting, and in the most severe cases, seizures and coma.  ADEM typically damages white matter (brain tissue that takes its name from the white color of myelin), leading to neurological symptoms such as visual loss (due to inflammation of the optic nerve) in one or both eyes, weakness even to the point of paralysis, and difficulty coordinating voluntary muscle movements (such as those used in walking).  ADEM is sometimes misdiagnosed as a severe first attack of multiple sclerosis (MS), since the symptoms and the appearance of the white matter injury on brain imaging may be similar.  However, ADEM has several features which differentiate it from MS.  First, unlike MS patients, persons with ADEM will have rapid onset of fever, a history of recent infection or immunization, and some degree of impairment of consciousness, perhaps even coma; these features are not typically seen in MS.  Children are more likely than adults to have ADEM, whereas MS is a rare diagnosis in children.  In addition, ADEM usually consists of a single episode or attack of widespread myelin damage, while MS features many attacks over the course of time. Doctors will often use imaging techniques, such as MRI (magnetic resonance imaging), to search for old and new lesions (areas of damage) on the brain.  The presence of older brain lesions on MRI suggest that the condition may be MS rather than ADEM, since MS can cause brain lesions before symptoms become obvious.  In rare situations, a brain biopsy may be necessary to differentiate between ADEM and some other diseases that involve inflammation and damage to myelin.

MalaCards based summary : Acute Disseminated Encephalomyelitis, also known as acute disseminated encephalitis, is related to panencephalitis, subacute sclerosing and allergic encephalomyelitis. An important gene associated with Acute Disseminated Encephalomyelitis is MBP (Myelin Basic Protein), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Actin Nucleation by ARP-WASP Complex. The drugs Prednisolone phosphate and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and heart, and related phenotypes are behavior/neurological and hematopoietic system

Disease Ontology : 12 An encephalomyelitis characterized by inflammation locatedin brain and locatedin spinal cord that damages myelin. It usually occurs after viral infection, but also following vaccination, bacterial or parasitic infection.

NIH Rare Diseases : 54 Acute disseminated encephalomyelitis (ADEM) is a neurological condition characterized by a brief but intense attack of inflammation in the brain and spinal cord. This may lead to damage of the layer of insulation around the nerves (myelin) within affected areas. ADEM often follows viral infection, or less often, vaccinations for measles, mumps, or rubella (MMR). Symptoms usually appear rapidly, beginning with fever, fatigue, headache, nausea and vomiting. Treatment for ADEM is targeted at suppressing inflammation in the brain using anti-inflammatory drugs. Most people begin to recover within days, with total or near-total recovery within a few months. Some people may have lifelong neurological impairments, and very rarely, severe cases can be fatal.

Wikipedia : 77 Acute disseminated encephalomyelitis (ADEM), or acute demyelinating encephalomyelitis, is a rare... more...

Related Diseases for Acute Disseminated Encephalomyelitis

Diseases related to Acute Disseminated Encephalomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1105)
# Related Disease Score Top Affiliating Genes
1 panencephalitis, subacute sclerosing 32.8 MBP MOG
2 allergic encephalomyelitis 32.4 MBP MOG
3 encephalitis 30.7 AQP4 IL1B MOG
4 pediatric multiple sclerosis 30.5 HLA-DQB1 HLA-DRB1 MOG
5 hypersomnia 30.3 HCRT HLA-DQB1 HLA-DRB1
6 myelitis 30.3 AQP4 MBP MOG
7 arthritis 30.2 HLA-DQB1 HLA-DRB1 IL10 IL1B
8 pure red-cell aplasia 30.1 HLA-DQB1 HLA-DRB1
9 acute transverse myelitis 30.1 AQP4 IL10
10 transverse myelitis 30.0 AQP4 IL10 MBP
11 rheumatic fever 30.0 HLA-DQA1 HLA-DRB1 IL10
12 rubella 30.0 HLA-B HLA-DQB1 HLA-DRB1 IL10 MOG
13 dengue hemorrhagic fever 30.0 HLA-B HLA-DRB1 IL10
14 intermediate uveitis 29.9 HLA-B IL10
15 chlamydia 29.9 HSPD1 IL10 IL1B
16 alexia 29.9 AQP4 MBP
17 optic neuritis 29.9 AQP4 HLA-DRB1 MBP MOG MPZ
18 guillain-barre syndrome 29.9 HCRT HLA-DQA1 HLA-DQB1 MBP MPZ
19 neuritis 29.9 AQP4 IL1B MBP MOG MPZ
20 toxoplasmosis 29.8 HLA-DQA1 HLA-DQB1 IL10 IL1B
21 asthma 29.7 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10 IL1B
22 systemic lupus erythematosus 29.6 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10 IL1B
23 juvenile rheumatoid arthritis 29.6 HLA-DQA1 HLA-DRB1 IL1B
24 trachoma 29.6 HSPD1 IL10
25 diabetes mellitus 29.5 HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 HSPD1 IL1B
26 demyelinating disease 29.5 AQP4 IL10 IL1B MBP MOG
27 multiple sclerosis 29.5 AQP4 HLA-DQB1 HLA-DRB1 IL10 IL1B MBP
28 complex regional pain syndrome 29.5 HLA-B IL10 IL1B
29 neuromyelitis optica 29.5 AQP4 HCRT HLA-DRB1 MBP MOG
30 optic nerve disease 29.5 AQP4 MBP MOG
31 psoriatic arthritis 29.5 HLA-B HLA-DRB1 IL1B
32 acquired immunodeficiency syndrome 29.5 HLA-B IL10 IL1B
33 endometritis 29.4 HLA-DQA1 HLA-DQB1 IL1B
34 fascioliasis 29.4 IL10 IL1B
35 narcolepsy 29.4 HCRT HLA-DQA1 HLA-DQB1 HLA-DRB1 MOG
36 rheumatoid arthritis 29.4 HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10 IL1B
37 rheumatic disease 29.3 HLA-B HLA-DRB1 IL10 IL1B
38 relapsing-remitting multiple sclerosis 29.2 AQP4 IL10 MBP MOG
39 peripheral nervous system disease 29.0 AQP4 MBP MOG MPZ
40 traumatic brain injury 29.0 AQP4 IL10 MBP
41 graft-versus-host disease 28.8 HLA-B HLA-DQB1 HLA-DRB1 IL10 IL1B
42 sudden infant death syndrome 28.7 AQP4 IL10 IL1B
43 autoimmune disease 28.3 HLA-DQB1 HLA-DRB1 HSPD1 IL10 IL1B MBP
44 alzheimer disease 12.2
45 hyper-ige recurrent infection syndrome 1, autosomal dominant 11.9
46 immunodeficiency 27b 11.8
47 myopathy, centronuclear, 1 11.7
48 renal tubular acidosis, distal, autosomal dominant 11.7
49 hypocalcemia, autosomal dominant 1 11.6
50 alzheimer disease 2 11.5

Graphical network of the top 20 diseases related to Acute Disseminated Encephalomyelitis:



Diseases related to Acute Disseminated Encephalomyelitis

Symptoms & Phenotypes for Acute Disseminated Encephalomyelitis

MGI Mouse Phenotypes related to Acute Disseminated Encephalomyelitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.86 AQP4 HCRT HLA-DQB1 HSPD1 IL10 MBP
2 hematopoietic system MP:0005397 9.76 AQP4 HLA-DQA1 HLA-DQB1 IL10 IL1B MBP
3 immune system MP:0005387 9.56 AQP4 HLA-DQA1 HLA-DQB1 IL10 IL1B MBP
4 nervous system MP:0003631 9.28 AQP4 HCRT HLA-DQB1 HSPD1 IL10 IL1B

Drugs & Therapeutics for Acute Disseminated Encephalomyelitis

Drugs for Acute Disseminated Encephalomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
2
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
3
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
4
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
5
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
6 Prednisolone acetate Phase 3
7 Peripheral Nervous System Agents Phase 3
8 Anti-Inflammatory Agents Phase 3
9 Hormones Phase 3
10 Autonomic Agents Phase 3
11 Hormone Antagonists Phase 3
12 Antiemetics Phase 3
13 Methylprednisolone Acetate Phase 3
14 Neuroprotective Agents Phase 3
15 Gastrointestinal Agents Phase 3
16 glucocorticoids Phase 3
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
18 Protective Agents Phase 3
19 Antibodies
20 Antibodies, Antiphospholipid
21 Immunoglobulins
22 interferons
23 polysaccharide-K
24 Antiviral Agents
25 Anti-Bacterial Agents
26 Interferon Inducers
27 Adjuvants, Immunologic
28 Anti-Infective Agents
29 Immunologic Factors
30 Antibiotics, Antitubercular
31 Radiation-Protective Agents
32 Vaccines

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study Completed NCT03226119 Phase 4
2 Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone Unknown status NCT00004645 Phase 3
3 Study Assessing Risk of Autoimmune Diseases in Females (9 - 25 Years) Exposed to Cervarix® in United Kingdom Completed NCT01953822
4 Quantitation of McArdle's Sign and Evaluation of Specificity for Multiple Sclerosis Completed NCT03122873
5 Centralized Reading Assessment of Chronic CerebroSpinal Venous Insufficiency (CCSVI) in Patients With Multiple Sclerosis and Other Neurological Diseases Completed NCT02308579
6 A Multicenter Observational Study to Evaluate Pediatric Multiple Sclerosis in Brazil Recruiting NCT03087136
7 A Surveillance Study of Diseases Specified as Adverse Events of Special Interest, of Other Adverse Events Leading to Hospitalisation or Death, and of Meningitis in Children in Africa Prior to Implementation of the RTS,S/AS01E Candidate Recruiting NCT02374450
8 Biobank For MS And Other Demyelinating Diseases Active, not recruiting NCT00445367
9 Management Of Acute Disseminating Encephalomyelitis Not yet recruiting NCT03284801
10 PEDIATRIC SONICS: Pediatric Study of Neuropsychology and Imaging in CNS Demyelinating Syndromes. Not yet recruiting NCT03942952

Search NIH Clinical Center for Acute Disseminated Encephalomyelitis

Genetic Tests for Acute Disseminated Encephalomyelitis

Anatomical Context for Acute Disseminated Encephalomyelitis

MalaCards organs/tissues related to Acute Disseminated Encephalomyelitis:

42
Brain, Spinal Cord, Heart, Eye, Bone, Liver, Prostate

Publications for Acute Disseminated Encephalomyelitis

Articles related to Acute Disseminated Encephalomyelitis:

(show top 50) (show all 705)
# Title Authors Year
1
Acute disseminated encephalomyelitis, a rare post-malaria neurological complication: Case report and review of the literature. ( 29574241 )
2019
2
Zika virus found in brain tissue of a multiple sclerosis patient undergoing an acute disseminated encephalomyelitis-like episode. ( 30226115 )
2019
3
Acute disseminated encephalomyelitis due to JC virus infection as the onset of non-Hodgkin's lymphoma. ( 30337110 )
2019
4
Increased Intracranial Pressure in Acute Disseminated Encephalomyelitis. ( 30477374 )
2019
5
Temporal Trends of Pediatric Hospitalizations with Acute Disseminated Encephalomyelitis in the United States: An Analysis from 2006 to 2014 using National Inpatient Sample. ( 30528761 )
2019
6
Acute disseminated encephalomyelitis in an older adult following prostate resection. ( 30619950 )
2019
7
Delayed appearance of transient hyperintensity foci on T1-weighted magnetic resonance imaging in acute disseminated encephalomyelitis. ( 30671706 )
2019
8
Vaccination-associated acute disseminated encephalomyelitis. ( 30683508 )
2019
9
Early predictors of epilepsy and subsequent relapse in children with acute disseminated encephalomyelitis. ( 30730236 )
2019
10
Acute Disseminated Encephalomyelitis After Chikungunya Infection. ( 30830174 )
2019
11
Clinical time course of pediatric acute disseminated encephalomyelitis. ( 30833092 )
2019
12
Acute disseminated encephalomyelitis in children - clinical and MRI decision making in the emergency department. ( 30846211 )
2019
13
Brain MRI Findings in Pediatric-Onset Neuromyelitis Optica Spectrum Disorder: Challenges in Differentiation from Acute Disseminated Encephalomyelitis. ( 30846436 )
2019
14
Gray variant of acute disseminated encephalomyelitis and its response to immunomodulatory drugs. ( 30860138 )
2019
15
Atypical Presentation of Acute Disseminated Encephalomyelitis (ADEM) in a Middle-Aged Adult. ( 30886135 )
2019
16
An interesting case of acute disseminated encephalomyelitis following E. coli infection. ( 30911524 )
2019
17
Early Recognition and Treatment of Acute Disseminated Encephalomyelitis in Pediatrics: A Case Series. ( 30973501 )
2019
18
Callosal lesions on magnetic resonance imaging with multiple sclerosis, neuromyelitis optica spectrum disorder and acute disseminated encephalomyelitis. ( 31030018 )
2019
19
Clinical Presentation and outcome of acute disseminated encephalomyelitis in Saudi Arabia. Tertiary Center Experience. ( 31056539 )
2019
20
Retinal haemorrhage in a child with optic neuritis and acute disseminated encephalomyelitis. ( 31061175 )
2019
21
Acute Disseminated Encephalomyelitis in an Incarcerated Adolescent Presents as Acute Psychosis: Case Report and Literature Review. ( 27749808 )
2019
22
Severe pemphigoid gestationis associated with acute disseminated encephalomyelitis in the setting of a systemic disorder. ( 28524368 )
2018
23
Ventricular Fibrillation Due to Early Repolarization Syndrome in the Wake of Hypothermia Due to Fulminant Acute Disseminated Encephalomyelitis. ( 28931785 )
2018
24
Diffusion Tensor Imaging as a Biomarker to Differentiate Acute Disseminated Encephalomyelitis From Multiple Sclerosis at First Demyelination. ( 29167056 )
2018
25
Acute disseminated encephalomyelitis associated with debut of a late onset coeliac disease-a case report. ( 29181653 )
2018
26
Necrotic-hemorrhagic myelitis: A rare malignant variant of parainfectious acute disseminated encephalomyelitis in childhood. ( 29249379 )
2018
27
Chemokines CXCL10, CXCL11, and CXCL13 in acute disseminated encephalomyelitis, non-polio enterovirus aseptic meningitis, and neuroborreliosis: CXCL10 as initial discriminator in diagnostic algorithm? ( 29288471 )
2018
28
Paediatric acute disseminated encephalomyelitis followed by optic neuritis: disease course, treatment response and outcome. ( 29443442 )
2018
29
Acute disseminated encephalomyelitis following Influenza A pneumonia. ( 29445493 )
2018
30
Use of Cyclophosphamide in a Child With Fulminant Acute Disseminated Encephalomyelitis. ( 29560383 )
2018
31
Acute Disseminated Encephalomyelitis After Herpes Simplex Virus Meningoencephalitis in Adult. ( 29581077 )
2018
32
Rituximab was effective for acute disseminated encephalomyelitis followed by recurrent optic neuritis with anti-myelin oligodendrocyte glycoprotein antibodies. ( 29661590 )
2018
33
Implications of the International Paediatric Multiple Sclerosis Study Group consensus criteria for paediatric acute disseminated encephalomyelitis: a nationwide validation study. ( 29744874 )
2018
34
Vaccines and the risk of acute disseminated encephalomyelitis. ( 29784468 )
2018
35
Relapsing acute disseminated encephalomyelitis followed by optic neuritis in children; a clinical entity associated with anti-MOG antibody. ( 29790244 )
2018
36
Acute Disseminated Encephalomyelitis-Masquerading as Pediatric Stroke: Case Report. ( 29899774 )
2018
37
How should we diagnose acute disseminated encephalomyelitis? ( 29926479 )
2018
38
A case of acute disseminated encephalomyelitis following Mycoplasma pneumoniae infection. ( 29942745 )
2018
39
Association of MOG-IgG Serostatus With Relapse After Acute Disseminated Encephalomyelitis and Proposed Diagnostic Criteria for MOG-IgG-Associated Disorders. ( 30014148 )
2018
40
Tigroid and leopard skin appearance in acute disseminated encephalomyelitis. ( 30038115 )
2018
41
Acute disseminated encephalomyelitis: a call to the clinicians for keeping this rare condition on clinical radar. ( 30050602 )
2018
42
Fatal acute disseminated encephalomyelitis (ADEM) after third ventricle colloid cyst resection with ultrasonic aspirator during neuroendoscopic procedure. ( 30058026 )
2018
43
Teaching Case 5-2018: Integrated morphological and immunological work-up of neurosurgical specimen allows accurate diagnosis of neuroinflammatory lesions: an example of acute disseminated encephalomyelitis (ADEM) associated with anti-MOG antibodies. ( 30103853 )
2018
44
Acute disseminated encephalomyelitis and reactivation of cerebral toxoplasmosis in a child: Case report. ( 30128290 )
2018
45
Acute Intermittent Porphyria: A Rare Cause of Acute Disseminated Encephalomyelitis. ( 30237948 )
2018
46
Acute disseminated encephalomyelitis: A rare autoimmune complication of herpes simplex encephalitis in the adult. ( 30336448 )
2018
47
Factors Related to Long Term Motor, Behavioral, and Scholastic Outcome in Children with Acute Disseminated Encephalomyelitis. ( 30409457 )
2018
48
Fulminant acute disseminated encephalomyelitis in children. ( 30522797 )
2018
49
Acute disseminated encephalomyelitis: complication of a vaccine preventable disease. ( 30593525 )
2018
50
Fatigue and physical functioning in children with multiple sclerosis and acute disseminated encephalomyelitis. ( 28445083 )
2018

Variations for Acute Disseminated Encephalomyelitis

Expression for Acute Disseminated Encephalomyelitis

Search GEO for disease gene expression data for Acute Disseminated Encephalomyelitis.

Pathways for Acute Disseminated Encephalomyelitis

Pathways related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.23 HLA-B HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
2
Show member pathways
12.85 HLA-B HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
3
Show member pathways
12.6 HLA-B HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 HSPD1
4
Show member pathways
12.52 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
5
Show member pathways
12.47 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10 IL1B
6
Show member pathways
12.43 HLA-B HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
7
Show member pathways
12.3 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
8
Show member pathways
12.26 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
9 12.23 HLA-B HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
10
Show member pathways
12.13 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
11 12.1 AQP4 HSPD1 IL10 IL1B
12
Show member pathways
12.07 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10 IL1B
13 12.01 HLA-B HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
14 11.88 AQP4 IL1B MBP
15
Show member pathways
11.87 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
16
Show member pathways
11.86 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
17 11.84 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
18 11.82 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
19 11.79 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL1B
20 11.73 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL1B
21 11.63 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
22 11.6 HLA-B HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 MPZ
23 11.5 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
24 11.42 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 HSPD1 IL10
25 11.39 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
26 11.19 HLA-DRB1 IL10 IL1B

GO Terms for Acute Disseminated Encephalomyelitis

Cellular components related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.91 HLA-B HLA-DPA1 HLA-DRB1 HSPD1 MBP
2 Golgi membrane GO:0000139 9.89 HLA-B HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
3 lysosomal membrane GO:0005765 9.83 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
4 lysosome GO:0005764 9.83 HLA-DPA1 HLA-DQA1 HLA-DRB1 IL1B MPZ
5 endosome membrane GO:0010008 9.76 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
6 secretory granule GO:0030141 9.72 HCRT HSPD1 IL1B
7 trans-Golgi network membrane GO:0032588 9.71 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
8 endocytic vesicle membrane GO:0030666 9.67 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
9 transport vesicle membrane GO:0030658 9.62 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
10 myelin sheath GO:0043209 9.56 MBP MPZ
11 clathrin-coated endocytic vesicle membrane GO:0030669 9.56 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
12 rough endoplasmic reticulum GO:0005791 9.48 HCRT MPZ
13 MHC class II protein complex GO:0042613 9.46 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
14 ER to Golgi transport vesicle membrane GO:0012507 9.35 HLA-B HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
15 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.02 HLA-B HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
16 plasma membrane GO:0005886 10.24 AQP4 HLA-B HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1

Biological processes related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.86 HLA-B HLA-DRB1 HSPD1 MOG
2 T cell receptor signaling pathway GO:0050852 9.72 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 MOG
3 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.67 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
4 interferon-gamma-mediated signaling pathway GO:0060333 9.65 HLA-B HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
5 positive regulation of interferon-gamma production GO:0032729 9.63 HLA-DPA1 HSPD1 IL1B
6 negative regulation of interferon-gamma production GO:0032689 9.58 HLA-DRB1 IL10
7 response to lipopolysaccharide GO:0032496 9.58 IL10 IL1B
8 positive regulation of T cell activation GO:0050870 9.57 HLA-DPA1 HSPD1
9 immune response GO:0006955 9.56 HLA-B HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
10 positive regulation of macrophage activation GO:0043032 9.54 HSPD1 IL10
11 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.52 IL10 IL1B
12 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.51 IL10 MBP
13 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.48 HLA-DQB1 HLA-DRB1
14 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.46 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
15 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.43 HLA-DQB1 HLA-DRB1
16 positive regulation of interleukin-6 secretion GO:2000778 9.4 IL1B MBP
17 response to ATP GO:0033198 9.25 IL1B
18 response to glucocorticoid GO:0051384 9.19 IL10
19 antigen processing and presentation GO:0019882 9.02 HLA-B HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1

Molecular functions related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 9.26 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
2 peptide antigen binding GO:0042605 9.02 HLA-B HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1

Sources for Acute Disseminated Encephalomyelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....