ADE
MCID: ACT049
MIFTS: 56

Acute Disseminated Encephalomyelitis (ADE)

Categories: Eye diseases, Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Acute Disseminated Encephalomyelitis

MalaCards integrated aliases for Acute Disseminated Encephalomyelitis:

Name: Acute Disseminated Encephalomyelitis 12 53 54 59 15
Acute Disseminated Encephalitis 12 59 73
Adem 12 53 59
Encephalomyelitis, Acute Disseminated 73
Encephalomyelitis Acute Disseminated 55
Ade 53

Characteristics:

Orphanet epidemiological data:

59
acute disseminated encephalomyelitis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



External Ids:

Disease Ontology 12 DOID:639
MeSH 44 D004673
NCIt 50 C34578
SNOMED-CT 68 83942000
Orphanet 59 ORPHA83597
ICD10 via Orphanet 34 G04.0
UMLS via Orphanet 74 C0014059
ICD10 33 G04.0

Summaries for Acute Disseminated Encephalomyelitis

NINDS : 54 Acute disseminated encephalomyelitis (ADEM) is characterized by a brief but widespread attack of inflammation in the brain and spinal cord that damages myelin – the protective covering of nerve fibers.  ADEM often follows viral or bacterial infections, or less often, vaccination for measles, mumps, or rubella.  The symptoms of ADEM appear rapidly, beginning with encephalitis-like symptoms such as fever, fatigue, headache, nausea and vomiting, and in the most severe cases, seizures and coma.  ADEM typically damages white matter (brain tissue that takes its name from the white color of myelin), leading to neurological symptoms such as visual loss (due to inflammation of the optic nerve) in one or both eyes, weakness even to the point of paralysis, and difficulty coordinating voluntary muscle movements (such as those used in walking).  ADEM is sometimes misdiagnosed as a severe first attack of multiple sclerosis (MS), since the symptoms and the appearance of the white matter injury on brain imaging may be similar.  However, ADEM has several features which differentiate it from MS.  First, unlike MS patients, persons with ADEM will have rapid onset of fever, a history of recent infection or immunization, and some degree of impairment of consciousness, perhaps even coma; these features are not typically seen in MS.  Children are more likely than adults to have ADEM, whereas MS is a rare diagnosis in children.  In addition, ADEM usually consists of a single episode or attack of widespread myelin damage, while MS features many attacks over the course of time. Doctors will often use imaging techniques, such as MRI (magnetic resonance imaging), to search for old and new lesions (areas of damage) on the brain.  The presence of older brain lesions on MRI suggest that the condition may be MS rather than ADEM, since MS can cause brain lesions before symptoms become obvious.  In rare situations, a brain biopsy may be necessary to differentiate between ADEM and some other diseases that involve inflammation and damage to myelin.

MalaCards based summary : Acute Disseminated Encephalomyelitis, also known as acute disseminated encephalitis, is related to allergic encephalomyelitis and encephalitis. An important gene associated with Acute Disseminated Encephalomyelitis is MBP (Myelin Basic Protein), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Actin Nucleation by ARP-WASP Complex. The drugs Prednisolone and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and eye, and related phenotypes are behavior/neurological and hematopoietic system

Disease Ontology : 12 An encephalomyelitis characterized by inflammation locatedin brain and locatedin spinal cord that damages myelin. It usually occurs after viral infection, but also following vaccination, bacterial or parasitic infection.

NIH Rare Diseases : 53 Acute disseminated encephalomyelitis (ADEM) is a neurological condition characterized by a brief but intense attack of inflammation in the brain and spinal cord. This may lead to damage of the layer of insulation around the nerves (myelin) within affected areas. ADEM often follows viral infection, or less often, vaccinations for measles, mumps, or rubella (MMR). Symptoms usually appear rapidly, beginning with fever, fatigue, headache, nausea and vomiting. Treatment for ADEM is targeted at suppressing inflammation in the brain using anti-inflammatory drugs. Most people begin to recover within days, with total or near-total recovery within a few months. Some people may have lifelong neurological impairments, and very rarely, severe cases can be fatal.

Wikipedia : 76 Acute disseminated encephalomyelitis (ADEM), or acute demyelinating encephalomyelitis, is a rare... more...

Related Diseases for Acute Disseminated Encephalomyelitis

Diseases related to Acute Disseminated Encephalomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 974)
# Related Disease Score Top Affiliating Genes
1 allergic encephalomyelitis 32.2 MBP MOG
2 encephalitis 30.7 AQP4 IL1B MOG
3 panencephalitis, subacute sclerosing 30.4 MBP MOG
4 myelitis 30.3 AQP4 MBP MOG
5 pediatric multiple sclerosis 30.2 HLA-DQB1 HLA-DRB1 MOG
6 hypersomnia 30.2 HCRT HLA-DQB1 HLA-DRB1
7 transverse myelitis 30.2 AQP4 IL10 MBP
8 hemorrhagic fever 30.1 HLA-DRB1 IL10
9 rubella 30.1 HLA-B HLA-DQB1 HLA-DRB1 IL10 MOG
10 acute transverse myelitis 30.1 AQP4 IL10
11 neuritis 30.1 AQP4 IL1B MBP MOG MPZ
12 optic neuritis 30.0 AQP4 HLA-DRB1 MBP MOG MPZ
13 multiple sclerosis 30.0 AQP4 HLA-DQB1 HLA-DRB1 IL10 IL1B MBP
14 arthritis 30.0 HLA-DQB1 HLA-DRB1 IL10 IL1B
15 alexia 29.9 AQP4 MBP
16 rheumatic fever 29.9 HLA-DQA1 HLA-DRB1 IL10
17 intermediate uveitis 29.9 HLA-B IL10
18 dengue hemorrhagic fever 29.9 HLA-B HLA-DRB1 IL10
19 pure red-cell aplasia 29.8 HLA-B HLA-DRB1
20 systemic lupus erythematosus 29.8 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10 IL1B
21 demyelinating disease 29.8 AQP4 IL10 IL1B MBP MOG
22 toxoplasmosis 29.8 HLA-DQA1 HLA-DQB1 IL10 IL1B
23 guillain-barre syndrome 29.8 HCRT HLA-DQB1 MBP MPZ
24 neuromyelitis optica 29.7 AQP4 HCRT HLA-DRB1 MBP MOG
25 diabetes mellitus 29.6 HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 HSPD1 IL1B
26 asthma 29.6 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10 IL1B
27 optic nerve disease 29.6 AQP4 MBP MOG
28 chlamydia 29.5 HSPD1 IL10 IL1B
29 trachoma 29.5 HSPD1 IL10
30 relapsing-remitting multiple sclerosis 29.5 AQP4 IL10 MBP MOG
31 rheumatoid arthritis 29.4 HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10 IL1B
32 fascioliasis 29.3 IL10 IL1B
33 celiac disease 1 29.3 HLA-DPA1 HLA-DQA1 HLA-DQB1 IL10
34 endometritis 29.3 HLA-DQA1 HLA-DQB1 IL1B
35 rheumatic disease 29.3 HLA-B HLA-DRB1 IL10 IL1B
36 microscopic polyangiitis 29.3 HLA-B HLA-DRB1 IL10
37 complex regional pain syndrome 29.2 HLA-B IL10 IL1B
38 peripheral nervous system disease 29.2 AQP4 MBP MOG MPZ
39 acquired immunodeficiency syndrome 29.2 HLA-B IL10 IL1B
40 juvenile rheumatoid arthritis 29.2 HLA-DQA1 HLA-DRB1 IL1B
41 leprosy 3 29.2 HLA-DRB1 HSPD1 IL10
42 psoriatic arthritis 29.2 HLA-B HLA-DRB1 IL1B
43 inflammatory bowel disease 29.1 HLA-B HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
44 graft-versus-host disease 28.9 HLA-B HLA-DQB1 HLA-DRB1 IL10 IL1B
45 traumatic brain injury 28.9 AQP4 IL10 MBP
46 sudden infant death syndrome 28.9 AQP4 IL10 IL1B
47 narcolepsy 28.7 AQP4 HCRT HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
48 diabetes mellitus, insulin-dependent 28.7 HLA-DQA1 HLA-DQB1 HLA-DRB1 HSPD1 IL10 IL1B
49 autoimmune disease 28.0 HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 HSPD1 IL10
50 alzheimer disease 12.2

Graphical network of the top 20 diseases related to Acute Disseminated Encephalomyelitis:



Diseases related to Acute Disseminated Encephalomyelitis

Symptoms & Phenotypes for Acute Disseminated Encephalomyelitis

MGI Mouse Phenotypes related to Acute Disseminated Encephalomyelitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.86 AQP4 HCRT HLA-DQB1 HSPD1 IL10 MBP
2 hematopoietic system MP:0005397 9.76 AQP4 HLA-DQA1 HLA-DQB1 IL10 IL1B MBP
3 immune system MP:0005387 9.56 AQP4 HLA-DQA1 HLA-DQB1 IL10 IL1B MBP
4 nervous system MP:0003631 9.28 AQP4 HCRT HLA-DQB1 HSPD1 IL10 IL1B

Drugs & Therapeutics for Acute Disseminated Encephalomyelitis

Drugs for Acute Disseminated Encephalomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
2
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
3
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
4
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
5
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
6 Methylprednisolone acetate Phase 3
7 Protective Agents Phase 3
8 Prednisolone acetate Phase 3
9 Anti-Inflammatory Agents Phase 3
10 Peripheral Nervous System Agents Phase 3
11 Hormone Antagonists Phase 3
12 Gastrointestinal Agents Phase 3
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
14 glucocorticoids Phase 3
15 Hormones Phase 3
16 Autonomic Agents Phase 3
17 Antiemetics Phase 3
18 Neuroprotective Agents Phase 3
19 Antibodies, Antiphospholipid
20 Immunoglobulins
21 Antibodies
22 Immunologic Factors
23 Adjuvants, Immunologic
24 Antiviral Agents
25 Anti-Bacterial Agents
26 Antibiotics, Antitubercular
27 Radiation-Protective Agents
28 Krestin
29 Anti-Infective Agents
30 interferons
31 Interferon Inducers
32 Vaccines Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone Unknown status NCT00004645 Phase 3
2 Study Assessing Risk of Autoimmune Diseases in Females (9 - 25 Years) Exposed to Cervarix® in United Kingdom Completed NCT01953822
3 Quantitation of McArdle's Sign and Evaluation of Specificity for Multiple Sclerosis Completed NCT03122873
4 Centralized Reading Assessment of Chronic CerebroSpinal Venous Insufficiency (CCSVI) in Patients With Multiple Sclerosis and Other Neurological Diseases Completed NCT02308579
5 A Multicenter Observational Study to Evaluate Pediatric Multiple Sclerosis in Brazil Recruiting NCT03087136
6 A Surveillance Study of Diseases Specified as Adverse Events of Special Interest, of Other Adverse Events Leading to Hospitalisation or Death, and of Meningitis in Children in Africa Prior to Implementation of the RTS,S/AS01E Candidate Recruiting NCT02374450 Not Applicable
7 Biobank For MS And Other Demyelinating Diseases Active, not recruiting NCT00445367
8 Management Of Acute Disseminating Encephalomyelitis Not yet recruiting NCT03284801

Search NIH Clinical Center for Acute Disseminated Encephalomyelitis

Genetic Tests for Acute Disseminated Encephalomyelitis

Anatomical Context for Acute Disseminated Encephalomyelitis

MalaCards organs/tissues related to Acute Disseminated Encephalomyelitis:

41
Brain, Spinal Cord, Eye, Liver, Heart, Kidney, Breast

Publications for Acute Disseminated Encephalomyelitis

Articles related to Acute Disseminated Encephalomyelitis:

(show top 50) (show all 690)
# Title Authors Year
1
Acute disseminated encephalomyelitis, a rare post-malaria neurological complication: Case report and review of the literature. ( 29574241 )
2018
2
Use of Cyclophosphamide in a Child With Fulminant Acute Disseminated Encephalomyelitis. ( 29560383 )
2018
3
Necrotic-hemorrhagic myelitis: A rare malignant variant of parainfectious acute disseminated encephalomyelitis in childhood. ( 29249379 )
2018
4
A case of acute disseminated encephalomyelitis following <i>Mycoplasma pneumoniae</i> infection. ( 29942745 )
2018
5
Vaccines and the risk of acute disseminated encephalomyelitis. ( 29784468 )
2018
6
Relapsing acute disseminated encephalomyelitis followed by optic neuritis in children; a clinical entity associated with anti-MOG antibody. ( 29790244 )
2018
7
Acute Disseminated Encephalomyelitis After Herpes Simplex Virus Meningoencephalitis in Adult. ( 29581077 )
2018
8
Implications of the International Paediatric Multiple Sclerosis Study Group consensus criteria for paediatric acute disseminated encephalomyelitis: a nationwide validation study. ( 29744874 )
2018
9
Rituximab was effective for acute disseminated encephalomyelitis followed by recurrent optic neuritis with anti-myelin oligodendrocyte glycoprotein antibodies. ( 29661590 )
2018
10
Acute Disseminated Encephalomyelitis-Masquerading as Pediatric Stroke: Case Report. ( 29899774 )
2018
11
Acute disseminated encephalomyelitis following Influenza A pneumonia. ( 29445493 )
2018
12
Diffusion Tensor Imaging as a Biomarker to Differentiate Acute Disseminated Encephalomyelitis From Multiple Sclerosis at First Demyelination. ( 29167056 )
2018
13
Fulminant acute disseminated encephalomyelitis in children. ( 30522797 )
2018
14
Acute disseminated encephalomyelitis associated with debut of a late onset coeliac disease-a case report. ( 29181653 )
2018
15
How should we diagnose acute disseminated encephalomyelitis? ( 29926479 )
2018
16
Association of MOG-IgG Serostatus With Relapse After Acute Disseminated Encephalomyelitis and Proposed Diagnostic Criteria for MOG-IgG-Associated Disorders. ( 30014148 )
2018
17
Tigroid and leopard skin appearance in acute disseminated encephalomyelitis. ( 30038115 )
2018
18
Acute disseminated encephalomyelitis: a call to the clinicians for keeping this rare condition on clinical radar. ( 30050602 )
2018
19
Fatal acute disseminated encephalomyelitis (ADEM) after third ventricle colloid cyst resection with ultrasonic aspirator during neuroendoscopic procedure. ( 30058026 )
2018
20
Teaching Case 5-2018: Integrated morphological and immunological work-up of neurosurgical specimen allows accurate diagnosis of neuroinflammatory lesions: an example of acute disseminated encephalomyelitis (ADEM) associated with anti-MOG antibodies. ( 30103853 )
2018
21
Acute disseminated encephalomyelitis and reactivation of cerebral toxoplasmosis in a child: Case report. ( 30128290 )
2018
22
Zika virus found in brain tissue of a multiple sclerosis patient undergoing an acute disseminated encephalomyelitis-like episode. ( 30226115 )
2018
23
Acute Intermittent Porphyria: A Rare Cause of Acute Disseminated Encephalomyelitis. ( 30237948 )
2018
24
Acute disseminated encephalomyelitis: A rare autoimmune complication of herpes simplex encephalitis in the adult. ( 30336448 )
2018
25
Acute disseminated encephalomyelitis due to JC virus infection as the onset of non-Hodgkin's lymphoma. ( 30337110 )
2018
26
Factors Related to Long Term Motor, Behavioral, and Scholastic Outcome in Children with Acute Disseminated Encephalomyelitis. ( 30409457 )
2018
27
Increased Intracranial Pressure in Acute Disseminated Encephalomyelitis. ( 30477374 )
2018
28
Temporal Trends of Pediatric Hospitalizations with Acute Disseminated Encephalomyelitis in the United States: An Analysis from 2006 to 2014 using National Inpatient Sample. ( 30528761 )
2018
29
The many faces of demyelinating diseases: acute disseminated encephalomyelitis and Guillain-BarrAc syndrome in the same patient. ( 28591395 )
2017
30
A case of CD30+ ALK1- anaplastic large cell lymphoma resembling acute disseminated encephalomyelitis. ( 28427693 )
2017
31
Human herpesvirus 6 encephalitis followed by acute disseminated encephalomyelitis in an immunocompetent adult. ( 28367948 )
2017
32
Severe pemphigoid gestationis associated with acute disseminated encephalomyelitis in the setting of a systemic disorder. ( 28524368 )
2017
33
Paraneoplastic acute disseminated encephalomyelitis associated with multiple myeloma. ( 28427695 )
2017
34
Acute disseminated encephalomyelitis: prognostic value of early follow-up brain MRI. ( 28695361 )
2017
35
X-linked Charcot-Marie-Tooth disease with GJB1 mutation presenting as acute disseminated encephalomyelitis-like illness: A case report. ( 29245364 )
2017
36
Lethal high: acute disseminated encephalomyelitis (ADEM) triggered by toxic effect of synthetic cannabinoid black mamba. ( 28433979 )
2017
37
Fatigue and physical functioning in children with multiple sclerosis and acute disseminated encephalomyelitis. ( 28445083 )
2017
38
Acute Disseminated Encephalomyelitis Presenting as an Isolated Mesodiencephalic Junction Lesion. ( 28694629 )
2017
39
Isolated palatal weakness without optic neuritis as the presenting manifestation of multiple sclerosis and its diagnostic dilemma with acute disseminated encephalomyelitis in a young boy. ( 28469990 )
2017
40
Guillain-BarrAc Syndrome, Acute Disseminated Encephalomyelitis and Encephalitis Associated with Zika Virus Infection in Brazil: Detection of Viral RNA and Isolation of Virus during Late Infection. ( 29140242 )
2017
41
Acute disseminated encephalomyelitis in an elderly patient. ( 28656376 )
2017
42
Tumefactive acute disseminated encephalomyelitis. ( 28488621 )
2017
43
Ventricular Fibrillation Due to Early Repolarization Syndrome in the Wake of Hypothermia Due to Fulminant Acute Disseminated Encephalomyelitis. ( 28931785 )
2017
44
Post-dengue acute disseminated encephalomyelitis: A case report and meta-analysis. ( 28665957 )
2017
45
Long-Term Neuropsychological Outcomes of Childhood Onset Acute Disseminated Encephalomyelitis (ADEM): a Meta-Analysis. ( 28364141 )
2017
46
Acute Disseminated Encephalomyelitis: A Gray Distinction. ( 28173990 )
2017
47
Methodological Challenges in Protein Microarray and Immunohistochemistry for the Discovery of Novel Autoantibodies in Paediatric Acute Disseminated Encephalomyelitis. ( 28327523 )
2017
48
Acute disseminated encephalomyelitis in China, Singapore and Japan: a comparison with the USA. ( 28009079 )
2017
49
Acute Disseminated Encephalomyelitis Following Zika Virus Infection. ( 27894121 )
2017
50
Chemokines CXCL10, CXCL11, and CXCL13 in acute disseminated encephalomyelitis, non-polio enterovirus aseptic meningitis, and neuroborreliosis: CXCL10 as initial discriminator in diagnostic algorithm? ( 29288471 )
2017

Variations for Acute Disseminated Encephalomyelitis

Expression for Acute Disseminated Encephalomyelitis

Search GEO for disease gene expression data for Acute Disseminated Encephalomyelitis.

Pathways for Acute Disseminated Encephalomyelitis

Pathways related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.25 HLA-B HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
2
Show member pathways
12.86 HLA-B HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
3
Show member pathways
12.68 HLA-B HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL1B
4
Show member pathways
12.6 HLA-B HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 HSPD1
5
Show member pathways
12.54 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
6
Show member pathways
12.47 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10 IL1B
7
Show member pathways
12.45 HLA-B HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
8 12.33 HLA-B HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
9
Show member pathways
12.31 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
10
Show member pathways
12.27 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
11 12.18 HLA-B HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
12
Show member pathways
12.14 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
13 12.11 AQP4 HSPD1 IL10 IL1B
14
Show member pathways
12.07 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10 IL1B
15 12.01 HLA-B HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
16 11.89 AQP4 IL1B MBP
17
Show member pathways
11.89 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
18
Show member pathways
11.88 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
19 11.86 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
20 11.85 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
21 11.79 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL1B
22 11.72 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL1B
23 11.65 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
24 11.59 HLA-B HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 MPZ
25 11.51 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
26 11.42 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 HSPD1 IL10
27 11.3 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
28 11.21 HLA-DRB1 IL10 IL1B

GO Terms for Acute Disseminated Encephalomyelitis

Cellular components related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.91 HLA-B HLA-DPA1 HLA-DRB1 HSPD1 MBP
2 Golgi membrane GO:0000139 9.89 HLA-B HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
3 lysosomal membrane GO:0005765 9.83 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
4 lysosome GO:0005764 9.83 HLA-DPA1 HLA-DQA1 HLA-DRB1 IL1B MPZ
5 endosome membrane GO:0010008 9.76 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
6 myelin sheath GO:0043209 9.73 HSPD1 MBP MPZ
7 secretory granule GO:0030141 9.72 HCRT HSPD1 IL1B
8 trans-Golgi network membrane GO:0032588 9.71 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
9 endocytic vesicle membrane GO:0030666 9.67 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
10 rough endoplasmic reticulum GO:0005791 9.65 HCRT HSPD1 MPZ
11 transport vesicle membrane GO:0030658 9.62 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
12 clathrin-coated endocytic vesicle membrane GO:0030669 9.56 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
13 MHC class II protein complex GO:0042613 9.46 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
14 ER to Golgi transport vesicle membrane GO:0012507 9.35 HLA-B HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
15 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.02 HLA-B HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
16 plasma membrane GO:0005886 10.24 AQP4 HLA-B HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1

Biological processes related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.86 HLA-B HLA-DRB1 HSPD1 MOG
2 response to lipopolysaccharide GO:0032496 9.75 HSPD1 IL10 IL1B
3 T cell receptor signaling pathway GO:0050852 9.72 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 MOG
4 response to glucocorticoid GO:0051384 9.67 HSPD1 IL10 IL1B
5 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.67 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
6 interferon-gamma-mediated signaling pathway GO:0060333 9.65 HLA-B HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
7 positive regulation of interferon-gamma production GO:0032729 9.63 HLA-DPA1 HSPD1 IL1B
8 negative regulation of interferon-gamma production GO:0032689 9.58 HLA-DRB1 IL10
9 positive regulation of interleukin-6 secretion GO:2000778 9.58 HSPD1 IL1B MBP
10 positive regulation of T cell activation GO:0050870 9.57 HLA-DPA1 HSPD1
11 immune response GO:0006955 9.56 HLA-B HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
12 response to ATP GO:0033198 9.55 HSPD1 IL1B
13 positive regulation of macrophage activation GO:0043032 9.54 HSPD1 IL10
14 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.52 IL10 IL1B
15 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.51 IL10 MBP
16 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.48 HLA-DQB1 HLA-DRB1
17 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.46 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
18 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.43 HLA-DQB1 HLA-DRB1
19 antigen processing and presentation GO:0019882 9.02 HLA-B HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1

Molecular functions related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 9.26 HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1
2 peptide antigen binding GO:0042605 9.02 HLA-B HLA-DPA1 HLA-DQA1 HLA-DQB1 HLA-DRB1

Sources for Acute Disseminated Encephalomyelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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