MCID: ACT049
MIFTS: 50

Acute Disseminated Encephalomyelitis

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Acute Disseminated Encephalomyelitis

MalaCards integrated aliases for Acute Disseminated Encephalomyelitis:

Name: Acute Disseminated Encephalomyelitis 12 53 59 15
Acute Disseminated Encephalitis 12 59 73
Adem 12 53 59
Encephalomyelitis, Acute Disseminated 73
Encephalomyelitis Acute Disseminated 55
Ade 53

Characteristics:

Orphanet epidemiological data:

59
acute disseminated encephalomyelitis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:639
MeSH 44 D004673
NCIt 50 C34578
SNOMED-CT 68 83942000
Orphanet 59 ORPHA83597
ICD10 via Orphanet 34 G04.0
UMLS via Orphanet 74 C0014059
ICD10 33 G04.0

Summaries for Acute Disseminated Encephalomyelitis

NINDS : 54 Acute disseminated encephalomyelitis (ADEM) is characterized by a brief but widespread attack of inflammation in the brain and spinal cord that damages myelin – the protective covering of nerve fibers.  ADEM often follows viral or bacterial infections, or less often, vaccination for measles, mumps, or rubella.  The symptoms of ADEM appear rapidly, beginning with encephalitis-like symptoms such as fever, fatigue, headache, nausea and vomiting, and in the most severe cases, seizures and coma.  ADEM typically damages white matter (brain tissue that takes its name from the white color of myelin), leading to neurological symptoms such as visual loss (due to inflammation of the optic nerve) in one or both eyes, weakness even to the point of paralysis, and difficulty coordinating voluntary muscle movements (such as those used in walking).  ADEM is sometimes misdiagnosed as a severe first attack of multiple sclerosis (MS), since the symptoms and the appearance of the white matter injury on brain imaging may be similar.  However, ADEM has several features which differentiate it from MS.  First, unlike MS patients, persons with ADEM will have rapid onset of fever, a history of recent infection or immunization, and some degree of impairment of consciousness, perhaps even coma; these features are not typically seen in MS.  Children are more likely than adults to have ADEM, whereas MS is a rare diagnosis in children.  In addition, ADEM usually consists of a single episode or attack of widespread myelin damage, while MS features many attacks over the course of time. Doctors will often use imaging techniques, such as MRI (magnetic resonance imaging), to search for old and new lesions (areas of damage) on the brain.  The presence of older brain lesions on MRI suggest that the condition may be MS rather than ADEM, since MS can cause brain lesions before symptoms become obvious.  In rare situations, a brain biopsy may be necessary to differentiate between ADEM and some other diseases that involve inflammation and damage to myelin.

MalaCards based summary : Acute Disseminated Encephalomyelitis, also known as acute disseminated encephalitis, is related to acute hemorrhagic leukoencephalitis and panencephalitis, subacute sclerosing. An important gene associated with Acute Disseminated Encephalomyelitis is MBP (Myelin Basic Protein), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Actin Nucleation by ARP-WASP Complex. The drugs Prednisolone and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and eye.

Disease Ontology : 12 An encephalomyelitis characterized by inflammation locatedin brain and locatedin spinal cord that damages myelin. It usually occurs after viral infection, but also following vaccination, bacterial or parasitic infection.

NIH Rare Diseases : 53 Acute disseminated encephalomyelitis (ADEM) is a neurological condition characterized by a brief but intense attack of inflammation in the brain and spinal cord. This may lead to damage of the layer of insulation around the nerves (myelin) within affected areas. ADEM often follows viral infection, or less often, vaccinations for measles, mumps, or rubella (MMR). Symptoms usually appear rapidly, beginning with fever, fatigue, headache, nausea and vomiting. Treatment for ADEM is targeted at suppressing inflammation in the brain using anti-inflammatory drugs. Most people begin to recover within days, with total or near-total recovery within a few months. Some people may have lifelong neurological impairments, and very rarely, severe cases can be fatal.

Wikipedia : 76 Acute disseminated encephalomyelitis (ADEM), or acute demyelinating encephalomyelitis, is a rare... more...

Related Diseases for Acute Disseminated Encephalomyelitis

Diseases related to Acute Disseminated Encephalomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 226)
# Related Disease Score Top Affiliating Genes
1 acute hemorrhagic leukoencephalitis 32.1 AQP4 MBP
2 panencephalitis, subacute sclerosing 30.5 MBP MOG
3 acute transverse myelitis 30.4 AQP4 IL10
4 intermediate uveitis 30.3 HLA-B IL10
5 hemorrhagic fever 30.1 HLA-DRB1 IL10
6 pure red-cell aplasia 30.0 HLA-B HLA-DRB1
7 pediatric multiple sclerosis 30.0 HLA-DQB1 HLA-DRB1 MOG
8 neuritis 29.9 AQP4 MBP MOG
9 myelitis 29.9 AQP4 MBP MOG
10 transverse myelitis 29.6 AQP4 IL10 MBP
11 dengue hemorrhagic fever 29.4 HLA-DRB1 IL10
12 hypersomnia 29.3 HCRT HLA-DQB1 HLA-DRB1
13 optic nerve disease 29.2 AQP4 MBP MOG
14 demyelinating disease 29.1 AQP4 IL10 MBP MOG
15 systemic lupus erythematosus 29.1 HLA-DPA1 HLA-DQB1 HLA-DRB1 IL10
16 optic neuritis 29.1 AQP4 HLA-DRB1 MBP MOG
17 rubella 28.9 HLA-B HLA-DQB1 HLA-DRB1 IL10 MOG
18 relapsing-remitting multiple sclerosis 28.6 AQP4 IL10 MBP MOG
19 multiple sclerosis 28.3 AQP4 HLA-DQB1 HLA-DRB1 IL10 MBP MOG
20 inflammatory bowel disease 28.1 HLA-B HLA-DPA1 HLA-DQB1 HLA-DRB1 IL10
21 neuromyelitis optica 27.5 AQP4 HCRT HLA-DRB1 MBP MOG
22 narcolepsy 26.7 AQP4 HCRT HLA-B HLA-DQB1 HLA-DRB1 MOG
23 alzheimer disease 12.0
24 dopa-responsive dystonia; segawa syndrome ad 11.9
25 hyper-ige recurrent infection syndrome, autosomal dominant 11.7
26 immunodeficiency 27b 11.6
27 myopathy, centronuclear, 1 11.5
28 renal tubular acidosis, distal, autosomal dominant 11.5
29 hypocalcemia, autosomal dominant 1 11.4
30 alzheimer disease 2 11.4
31 emery-dreifuss muscular dystrophy 2, autosomal dominant 11.2
32 post-vaccinal encephalitis 11.2
33 frontotemporal dementia 11.2
34 striatonigral degeneration, infantile 11.2
35 immune-mediated encephalomyelitis 11.2
36 postinfectious encephalomyelitis 11.2
37 dermatitis, atopic 11.1
38 early-onset, autosomal dominant alzheimer disease 11.1
39 posterior cortical atrophy 11.0
40 eosinophilic granulomatosis with polyangiitis 11.0
41 idiopathic achalasia 10.6 HLA-DQB1 IL10
42 cytomegalovirus retinitis 10.6 HLA-B HLA-DQB1
43 limbic encephalitis with lgi1 antibodies 10.5 HLA-DQB1 HLA-DRB1
44 metal allergy 10.5 HLA-DQB1 HLA-DRB1
45 focal epithelial hyperplasia 10.5 HLA-DQB1 HLA-DRB1
46 lichen planopilaris 10.5 HLA-DQB1 HLA-DRB1
47 type ii mixed cryoglobulinemia 10.5 HLA-DQB1 HLA-DRB1
48 recurrent respiratory papillomatosis 10.5 HLA-DQB1 HLA-DRB1
49 autoimmune pancreatitis 10.5 HLA-DQB1 HLA-DRB1
50 lichen sclerosus 10.4 HLA-DQB1 HLA-DRB1

Graphical network of the top 20 diseases related to Acute Disseminated Encephalomyelitis:



Diseases related to Acute Disseminated Encephalomyelitis

Symptoms & Phenotypes for Acute Disseminated Encephalomyelitis

Drugs & Therapeutics for Acute Disseminated Encephalomyelitis

Drugs for Acute Disseminated Encephalomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
2
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
3 Prednisolone acetate Phase 3
4 glucocorticoids Phase 3
5 Methylprednisolone acetate Phase 3
6 Methylprednisolone Hemisuccinate Phase 3
7 Gastrointestinal Agents Phase 3
8 Neuroprotective Agents Phase 3
9 Hormone Antagonists Phase 3
10 Hormones Phase 3
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
12 Peripheral Nervous System Agents Phase 3
13 Prednisolone hemisuccinate Phase 3
14 Prednisolone phosphate Phase 3
15 Antiemetics Phase 3
16 Protective Agents Phase 3
17 Anti-Inflammatory Agents Phase 3
18 Autonomic Agents Phase 3
19 Antibodies
20 Immunoglobulins
21 Antibodies, Antiphospholipid
22 interferons
23 Adjuvants, Immunologic
24 Vaccines Not Applicable
25 Anti-Bacterial Agents
26 Antibiotics, Antitubercular
27 Anti-Infective Agents
28 Interferon Inducers
29 Krestin
30 Radiation-Protective Agents
31 Antiviral Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone Unknown status NCT00004645 Phase 3
2 Study Assessing Risk of Autoimmune Diseases in Females (9 - 25 Years) Exposed to Cervarix® in United Kingdom Completed NCT01953822
3 Quantitation of McArdle's Sign and Evaluation of Specificity for Multiple Sclerosis Completed NCT03122873
4 Centralized Reading Assessment of Chronic CerebroSpinal Venous Insufficiency (CCSVI) in Patients With Multiple Sclerosis and Other Neurological Diseases Completed NCT02308579
5 A Multicenter Observational Study to Evaluate Pediatric Multiple Sclerosis in Brazil Recruiting NCT03087136
6 A Surveillance Study of Diseases Specified as Adverse Events of Special Interest, of Other Adverse Events Leading to Hospitalisation or Death, and of Meningitis in Children in Africa Prior to Implementation of the RTS,S/AS01E Candidate Recruiting NCT02374450 Not Applicable
7 Biobank For MS And Other Demyelinating Diseases Active, not recruiting NCT00445367
8 Management Of Acute Disseminating Encephalomyelitis Not yet recruiting NCT03284801

Search NIH Clinical Center for Acute Disseminated Encephalomyelitis

Genetic Tests for Acute Disseminated Encephalomyelitis

Anatomical Context for Acute Disseminated Encephalomyelitis

MalaCards organs/tissues related to Acute Disseminated Encephalomyelitis:

41
Brain, Spinal Cord, Eye, T Cells, Bone, Bone Marrow, Lung

Publications for Acute Disseminated Encephalomyelitis

Articles related to Acute Disseminated Encephalomyelitis:

(show top 50) (show all 636)
# Title Authors Year
1
Acute disseminated encephalomyelitis, a rare post-malaria neurological complication: Case report and review of the literature. ( 29574241 )
2018
2
Use of Cyclophosphamide in a Child With Fulminant Acute Disseminated Encephalomyelitis. ( 29560383 )
2018
3
Necrotic-hemorrhagic myelitis: A rare malignant variant of parainfectious acute disseminated encephalomyelitis in childhood. ( 29249379 )
2018
4
A case of acute disseminated encephalomyelitis following <i>Mycoplasma pneumoniae</i> infection. ( 29942745 )
2018
5
Vaccines and the risk of acute disseminated encephalomyelitis. ( 29784468 )
2018
6
Relapsing acute disseminated encephalomyelitis followed by optic neuritis in children; a clinical entity associated with anti-MOG antibody. ( 29790244 )
2018
7
Acute Disseminated Encephalomyelitis After Herpes Simplex Virus Meningoencephalitis in Adult. ( 29581077 )
2018
8
Implications of the International Paediatric Multiple Sclerosis Study Group consensus criteria for paediatric acute disseminated encephalomyelitis: a nationwide validation study. ( 29744874 )
2018
9
Rituximab was effective for acute disseminated encephalomyelitis followed by recurrent optic neuritis with anti-myelin oligodendrocyte glycoprotein antibodies. ( 29661590 )
2018
10
Acute Disseminated Encephalomyelitis-Masquerading as Pediatric Stroke: Case Report. ( 29899774 )
2018
11
Acute disseminated encephalomyelitis following Influenza A pneumonia. ( 29445493 )
2018
12
Diffusion Tensor Imaging as a Biomarker to Differentiate Acute Disseminated Encephalomyelitis From Multiple Sclerosis at First Demyelination. ( 29167056 )
2018
13
How should we diagnose acute disseminated encephalomyelitis? ( 29926479 )
2018
14
The many faces of demyelinating diseases: acute disseminated encephalomyelitis and Guillain-BarrAc syndrome in the same patient. ( 28591395 )
2017
15
A case of CD30+ ALK1- anaplastic large cell lymphoma resembling acute disseminated encephalomyelitis. ( 28427693 )
2017
16
Human herpesvirus 6 encephalitis followed by acute disseminated encephalomyelitis in an immunocompetent adult. ( 28367948 )
2017
17
Severe pemphigoid gestationis associated with acute disseminated encephalomyelitis in the setting of a systemic disorder. ( 28524368 )
2017
18
Paraneoplastic acute disseminated encephalomyelitis associated with multiple myeloma. ( 28427695 )
2017
19
Acute disseminated encephalomyelitis: prognostic value of early follow-up brain MRI. ( 28695361 )
2017
20
X-linked Charcot-Marie-Tooth disease with GJB1 mutation presenting as acute disseminated encephalomyelitis-like illness: A case report. ( 29245364 )
2017
21
Lethal high: acute disseminated encephalomyelitis (ADEM) triggered by toxic effect of synthetic cannabinoid black mamba. ( 28433979 )
2017
22
Fatigue and physical functioning in children with multiple sclerosis and acute disseminated encephalomyelitis. ( 28445083 )
2017
23
Acute Disseminated Encephalomyelitis Presenting as an Isolated Mesodiencephalic Junction Lesion. ( 28694629 )
2017
24
Isolated palatal weakness without optic neuritis as the presenting manifestation of multiple sclerosis and its diagnostic dilemma with acute disseminated encephalomyelitis in a young boy. ( 28469990 )
2017
25
Guillain-BarrAc Syndrome, Acute Disseminated Encephalomyelitis and Encephalitis Associated with Zika Virus Infection in Brazil: Detection of Viral RNA and Isolation of Virus during Late Infection. ( 29140242 )
2017
26
Acute disseminated encephalomyelitis in an elderly patient. ( 28656376 )
2017
27
Tumefactive acute disseminated encephalomyelitis. ( 28488621 )
2017
28
Ventricular Fibrillation Due to Early Repolarization Syndrome in the Wake of Hypothermia Due to Fulminant Acute Disseminated Encephalomyelitis. ( 28931785 )
2017
29
Post-dengue acute disseminated encephalomyelitis: A case report and meta-analysis. ( 28665957 )
2017
30
Long-Term Neuropsychological Outcomes of Childhood Onset Acute Disseminated Encephalomyelitis (ADEM): a Meta-Analysis. ( 28364141 )
2017
31
Acute Disseminated Encephalomyelitis: A Gray Distinction. ( 28173990 )
2017
32
Methodological Challenges in Protein Microarray and Immunohistochemistry for the Discovery of Novel Autoantibodies in Paediatric Acute Disseminated Encephalomyelitis. ( 28327523 )
2017
33
Acute disseminated encephalomyelitis in China, Singapore and Japan: a comparison with the USA. ( 28009079 )
2017
34
Acute Disseminated Encephalomyelitis Following Zika Virus Infection. ( 27894121 )
2017
35
Chemokines CXCL10, CXCL11, and CXCL13 in acute disseminated encephalomyelitis, non-polio enterovirus aseptic meningitis, and neuroborreliosis: CXCL10 as initial discriminator in diagnostic algorithm? ( 29288471 )
2017
36
Childhood acute disseminated encephalomyelitis: an Egyptian pilot study. ( 29222716 )
2017
37
Acute disseminated encephalomyelitis in dengue viral infection. ( 28625589 )
2017
38
Acute disseminated encephalomyelitis associated with debut of a late onset coeliac disease-a case report. ( 29181653 )
2017
39
Acute Disseminated Encephalomyelitis. ( 27253358 )
2016
40
Neuroleptic Malignant Syndrome Associated with Refractory Acute Disseminated Encephalomyelitis. ( 27239186 )
2016
41
Acute Disseminated Encephalomyelitis After Human Parechovirus Infection. ( 26741581 )
2016
42
Treatment of hemorrhagic acute disseminated encephalomyelitis with cyclophosphamide. ( 26843496 )
2016
43
Pattern and Outcome of Acute Disseminated Encephalomyelitis (ADEM) in Children: Experience in a Tertiary Center, Upper Egypt. ( 27648197 )
2016
44
Cardiogenic shock from atypical Takotsubo cardiomyopathy attributed to acute disseminated encephalomyelitis lesion involving the medulla. ( 26868678 )
2016
45
Acute Disseminated Encephalomyelitis in an Incarcerated Adolescent Presents as Acute Psychosis: Case Report and Literature Review. ( 27749808 )
2016
46
Pandemic H1N1 Vaccination and Incidence of Acute Disseminated Encephalomyelitis in Manitoba. ( 27608932 )
2016
47
Acute Disseminated Encephalomyelitis Following Immunization with Human Papillomavirus Vaccines. ( 27803397 )
2016
48
Posttraumatic Acute Disseminated Encephalomyelitis in a Child Resolved by Steroid Therapy: Case Report. ( 26833988 )
2016
49
Acute Disseminated Encephalomyelitis after Oral Therapy with Herbal Extracts: A Case Report. ( 27308086 )
2016
50
Evolution of MRI abnormalities in paediatric acute disseminated encephalomyelitis. ( 27670632 )
2016

Variations for Acute Disseminated Encephalomyelitis

Expression for Acute Disseminated Encephalomyelitis

Search GEO for disease gene expression data for Acute Disseminated Encephalomyelitis.

Pathways for Acute Disseminated Encephalomyelitis

Pathways related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.11 HLA-B HLA-DPA1 HLA-DQB1 HLA-DRB1 IL10
2
Show member pathways
12.72 HLA-B HLA-DPA1 HLA-DQB1 HLA-DRB1
3
Show member pathways
12.56 HLA-B HLA-DPA1 HLA-DQB1 HLA-DRB1
4
Show member pathways
12.54 HLA-B HLA-DPA1 HLA-DQB1 HLA-DRB1 IL10
5
Show member pathways
12.36 HLA-DPA1 HLA-DQB1 HLA-DRB1
6
Show member pathways
12.29 HLA-B HLA-DPA1 HLA-DQB1 HLA-DRB1
7
Show member pathways
12.18 HLA-DPA1 HLA-DQB1 HLA-DRB1 IL10
8
Show member pathways
12.17 HLA-DPA1 HLA-DQB1 HLA-DRB1
9
Show member pathways
12.14 HLA-DPA1 HLA-DQB1 HLA-DRB1
10 12.14 HLA-B HLA-DPA1 HLA-DQB1 HLA-DRB1
11
Show member pathways
12.01 HLA-DPA1 HLA-DQB1 HLA-DRB1
12
Show member pathways
11.97 HLA-DPA1 HLA-DQB1 HLA-DRB1
13
Show member pathways
11.94 HLA-DPA1 HLA-DQB1 HLA-DRB1 IL10
14 11.88 HLA-DPA1 HLA-DQB1 HLA-DRB1 IL10
15
Show member pathways
11.76 HLA-DPA1 HLA-DQB1 HLA-DRB1
16 11.74 HLA-B HLA-DPA1 HLA-DQB1 HLA-DRB1
17 11.73 HLA-DPA1 HLA-DQB1 HLA-DRB1
18 11.73 HLA-DPA1 HLA-DQB1 HLA-DRB1
19 11.69 HLA-DPA1 HLA-DQB1 HLA-DRB1
20 11.66 HLA-B HLA-DPA1 HLA-DQB1 HLA-DRB1 IL10
21 11.64 HLA-DPA1 HLA-DQB1 HLA-DRB1
22 11.62 HLA-B HLA-DPA1 HLA-DQB1 HLA-DRB1
23 11.5 HLA-DPA1 HLA-DQB1 HLA-DRB1
24 11.08 HLA-DRB1 IL10
25 10.67 HLA-DPA1 HLA-DQB1 HLA-DRB1 IL10

GO Terms for Acute Disseminated Encephalomyelitis

Cellular components related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 Golgi membrane GO:0000139 9.73 HLA-B HLA-DPA1 HLA-DQB1 HLA-DRB1
2 lysosomal membrane GO:0005765 9.67 HLA-DPA1 HLA-DQB1 HLA-DRB1
3 external side of plasma membrane GO:0009897 9.65 AQP4 HLA-DRB1 MOG
4 endosome membrane GO:0010008 9.63 HLA-DPA1 HLA-DQB1 HLA-DRB1
5 trans-Golgi network membrane GO:0032588 9.58 HLA-DPA1 HLA-DQB1 HLA-DRB1
6 endocytic vesicle membrane GO:0030666 9.54 HLA-DPA1 HLA-DQB1 HLA-DRB1
7 transport vesicle membrane GO:0030658 9.5 HLA-DPA1 HLA-DQB1 HLA-DRB1
8 clathrin-coated endocytic vesicle membrane GO:0030669 9.43 HLA-DPA1 HLA-DQB1 HLA-DRB1
9 MHC class II protein complex GO:0042613 9.33 HLA-DPA1 HLA-DQB1 HLA-DRB1
10 ER to Golgi transport vesicle membrane GO:0012507 9.26 HLA-B HLA-DPA1 HLA-DQB1 HLA-DRB1
11 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.92 HLA-B HLA-DPA1 HLA-DQB1 HLA-DRB1

Biological processes related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.63 HLA-DPA1 HLA-DQB1 HLA-DRB1
2 T cell receptor signaling pathway GO:0050852 9.62 HLA-DPA1 HLA-DQB1 HLA-DRB1 MOG
3 T cell costimulation GO:0031295 9.61 HLA-DPA1 HLA-DQB1 HLA-DRB1
4 negative regulation of T cell proliferation GO:0042130 9.51 HLA-DRB1 IL10
5 negative regulation of interferon-gamma production GO:0032689 9.49 HLA-DRB1 IL10
6 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.48 IL10 MBP
7 interferon-gamma-mediated signaling pathway GO:0060333 9.46 HLA-B HLA-DPA1 HLA-DQB1 HLA-DRB1
8 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.43 HLA-DPA1 HLA-DQB1 HLA-DRB1
9 immune response GO:0006955 9.43 HLA-B HLA-DPA1 HLA-DQB1 HLA-DRB1 IL10 MBP
10 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.4 HLA-DQB1 HLA-DRB1
11 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.37 HLA-DQB1 HLA-DRB1
12 antigen processing and presentation GO:0019882 8.92 HLA-B HLA-DPA1 HLA-DQB1 HLA-DRB1

Molecular functions related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 9.13 HLA-DPA1 HLA-DQB1 HLA-DRB1
2 peptide antigen binding GO:0042605 8.92 HLA-B HLA-DPA1 HLA-DQB1 HLA-DRB1

Sources for Acute Disseminated Encephalomyelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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