ADE
MCID: ACT049
MIFTS: 51

Acute Disseminated Encephalomyelitis (ADE)

Categories: Eye diseases, Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Acute Disseminated Encephalomyelitis

MalaCards integrated aliases for Acute Disseminated Encephalomyelitis:

Name: Acute Disseminated Encephalomyelitis 12 52 53 58 15 17
Acute Disseminated Encephalitis 12 58 71 32
Adem 12 52 58
Encephalomyelitis, Acute Disseminated 71
Encephalomyelitis Acute Disseminated 54
Ade 52

Characteristics:

Orphanet epidemiological data:

58
acute disseminated encephalomyelitis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare neurological diseases
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:639
MeSH 43 D004673
NCIt 49 C34578
SNOMED-CT 67 83942000
ICD10 32 G04.0
ICD10 via Orphanet 33 G04.0
UMLS via Orphanet 72 C0014059
Orphanet 58 ORPHA83597
UMLS 71 C0014059 C3536864

Summaries for Acute Disseminated Encephalomyelitis

NINDS : 53 Acute disseminated encephalomyelitis (ADEM) is characterized by a brief but widespread attack of inflammation in the brain and spinal cord that damages myelin – the protective covering of nerve fibers.  ADEM often follows viral or bacterial infections, or less often, vaccination for measles, mumps, or rubella.  The symptoms of ADEM appear rapidly, beginning with encephalitis-like symptoms such as fever, fatigue, headache, nausea and vomiting, and in the most severe cases, seizures and coma.  ADEM typically damages white matter (brain tissue that takes its name from the white color of myelin), leading to neurological symptoms such as visual loss (due to inflammation of the optic nerve) in one or both eyes, weakness even to the point of paralysis, and difficulty coordinating voluntary muscle movements (such as those used in walking).  ADEM is sometimes misdiagnosed as a severe first attack of multiple sclerosis (MS), since the symptoms and the appearance of the white matter injury on brain imaging may be similar.  However, ADEM has several features which differentiate it from MS.  First, unlike MS patients, persons with ADEM will have rapid onset of fever, a history of recent infection or immunization, and some degree of impairment of consciousness, perhaps even coma; these features are not typically seen in MS.  Children are more likely than adults to have ADEM, whereas MS is a rare diagnosis in children.  In addition, ADEM usually consists of a single episode or attack of widespread myelin damage, while MS features many attacks over the course of time. Doctors will often use imaging techniques, such as MRI (magnetic resonance imaging), to search for old and new lesions (areas of damage) on the brain.  The presence of older brain lesions on MRI suggest that the condition may be MS rather than ADEM, since MS can cause brain lesions before symptoms become obvious.  In rare situations, a brain biopsy may be necessary to differentiate between ADEM and some other diseases that involve inflammation and damage to myelin.

MalaCards based summary : Acute Disseminated Encephalomyelitis, also known as acute disseminated encephalitis, is related to allergic encephalomyelitis and subacute sclerosing panencephalitis. An important gene associated with Acute Disseminated Encephalomyelitis is MBP (Myelin Basic Protein), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Vaccines and Antibodies, Blocking have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and heart, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 An encephalomyelitis characterized by inflammation locatedin brain and locatedin spinal cord that damages myelin. It usually occurs after viral infection, but also following vaccination, bacterial or parasitic infection.

NIH Rare Diseases : 52 Acute disseminated encephalomyelitis (ADEM) is a neurological condition characterized by a brief but intense attack of inflammation in the brain and spinal cord. This may lead to damage of the layer of insulation around the nerves (myelin ) within affected areas. ADEM often follows viral infection, or less often, vaccinations for measles, mumps, or rubella (MMR). Symptoms usually appear rapidly, beginning with fever, fatigue, headache, nausea and vomiting. Treatment for ADEM is targeted at suppressing inflammation in the brain using anti-inflammatory drugs. Most people begin to recover within days, with total or near-total recovery within a few months. Some people may have lifelong neurological impairments, and very rarely, severe cases can be fatal.

Wikipedia : 74 Acute disseminated encephalomyelitis (ADEM), or acute demyelinating encephalomyelitis, is a rare... more...

Related Diseases for Acute Disseminated Encephalomyelitis

Diseases related to Acute Disseminated Encephalomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1794)
# Related Disease Score Top Affiliating Genes
1 allergic encephalomyelitis 33.5 MOG MBP
2 subacute sclerosing panencephalitis 33.3 MOG MBP IL10
3 dermatitis, atopic 31.8 MBP IL1B IL10 CD40LG CCR6 CCL4
4 chronic mucocutaneous candidiasis 31.7 IL1B IL10 CSF3 CCR6
5 pediatric multiple sclerosis 31.6 MOG HLA-DRB1 HLA-DQB1
6 transverse myelitis 31.3 MBP IL10 AQP4
7 mumps 31.1 IL10 HLA-DRB1 HLA-DQB1 CD40LG
8 measles 31.0 IL1B HLA-DRB1 HLA-DQA1 CD40LG
9 hypersomnia 31.0 HLA-DRB1 HLA-DQB1 HCRT
10 acute transverse myelitis 31.0 IL10 AQP4
11 chickenpox 30.9 IL10 CD40LG CCR6
12 aseptic meningitis 30.9 IL1B IL10 CSF3 CD40LG
13 meningoencephalitis 30.7 MBP IL10 CD40LG CCR6
14 quadriplegia 30.7 MOG MBP CCR6
15 appendicitis 30.6 IL1B IL10 CSF3
16 bacterial meningitis 30.6 IL1B IL10 CCL4 AQP4
17 neuritis 30.6 MPZ MOG MBP IL1B IL10 CCL4
18 brain edema 30.6 IL1B CSF3 AQP4
19 nervous system disease 30.6 MOG MBP IL1B CCR6
20 tetanus 30.5 MBP IL1B IL10 CD40LG
21 pharyngitis 30.5 IL1B HLA-DRB1 CD40LG
22 red cell aplasia 30.5 HLA-DRB1 HLA-DQB1 HLA-B
23 leptospirosis 30.5 IL1B IL10 HLA-DRB1 CD40LG
24 pneumonia 30.5 IL1B IL10 CSF3 CD40LG
25 gastroenteritis 30.5 IL1B IL10 CSF3
26 diarrhea 30.5 IL1B IL10 CSF3 CD40LG
27 herpes zoster 30.5 IL10 HLA-DRB1 HLA-B CD40LG
28 dengue disease 30.5 CD40LG CCR6 CCL4
29 brain injury 30.4 MBP IL10 AQP4
30 lupus erythematosus 30.4 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1 CD40LG
31 exanthem 30.4 IL10 CSF3 CD40LG CCR6
32 traumatic brain injury 30.4 MBP IL10 AQP4
33 acute cystitis 30.4 IL10 CD40LG CCR6
34 plasmodium falciparum malaria 30.4 IL10 CD40LG CCL4
35 acute retrobulbar neuritis 30.3 MBP AQP4
36 neuromyelitis optica 30.3 MOG MBP HLA-DRB1 HCRT CD40LG AQP4
37 balo concentric sclerosis 30.3 MOG MBP AQP4
38 polyneuropathy 30.3 MPZ MBP IL1B CD40LG
39 graft-versus-host disease 30.3 IL1B IL10 HLA-DRB1 HLA-DQB1 HLA-B
40 scrub typhus 30.3 IL1B IL10 CD40LG
41 cerebral palsy 30.3 IL1B IL10 CSF3
42 central nervous system vasculitis 30.3 HLA-DRB1 CD40LG CCR6
43 dengue shock syndrome 30.3 IL1B HLA-DRB1 CD40LG
44 duodenal ulcer 30.3 IL1B IL10 HLA-DRB1
45 osteomyelitis 30.2 IL1B IL10 CSF3
46 gingivitis 30.2 IL1B IL10 CSF3
47 sleep apnea 30.2 IL1B IL10 HCRT
48 chlamydia 30.2 IL1B IL10 CD40LG
49 internuclear ophthalmoplegia 30.2 MOG LGI1 AQP4
50 autoimmune encephalitis 30.2 LGI1 HCRT CNTNAP2

Graphical network of the top 20 diseases related to Acute Disseminated Encephalomyelitis:



Diseases related to Acute Disseminated Encephalomyelitis

Symptoms & Phenotypes for Acute Disseminated Encephalomyelitis

MGI Mouse Phenotypes related to Acute Disseminated Encephalomyelitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.93 AQP4 CCR6 CD40LG CDH23 CSF3 HLA-DQA1
2 immune system MP:0005387 9.73 AQP4 CCR6 CD40LG CDH23 CSF3 HLA-DQA1
3 nervous system MP:0003631 9.47 AQP4 CCR6 CD40LG CDH23 CNTNAP2 DPYSL5

Drugs & Therapeutics for Acute Disseminated Encephalomyelitis

Drugs for Acute Disseminated Encephalomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4
2 Antibodies, Blocking Phase 4
3
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
4
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
6 Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
7
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
8
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
9 Methylprednisolone Acetate Phase 3
10
rituximab Approved Phase 2 174722-31-7 10201696
11 Antibodies Phase 2
12 Immunoglobulins Phase 2
13 Immunologic Factors Phase 2
14 Antineoplastic Agents, Immunological Phase 2
15 Antirheumatic Agents Phase 2
16 Autoantibodies
17 Anti-Bacterial Agents
18 interferons
19 Anti-Infective Agents
20 Antibiotics, Antitubercular
21 Adjuvants, Immunologic
22 Antiviral Agents
23 Protective Agents
24 polysaccharide-K
25 Radiation-Protective Agents
26 Interferon Inducers

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Neutralizing Antibody Titers 6 Years After the Third Dose of Inactivated Japanese Encephalitis Vaccine and Projected Duration of Protection Completed NCT02039440 Phase 4
2 Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone Unknown status NCT00004645 Phase 3
3 Randomized Clinical Trial of Plasma Exchanges Versus Sham Plasma Exchanges in Disabling Multiple Sclerosis Acute Relapses Refractory to Steroid Treatment Completed NCT01442233 Phase 3
4 Prospective Assessment of Efficacy of Immunoadsorption Therapy in Managing Childhood NMDA-Receptor (NMDAR) Antibodies Encephalitis Not yet recruiting NCT03274375 Phase 2 IA session;Rituximab
5 Management of Acute Disseminated Encephalomyelitis in Neurology Unit of Assiut University Children Hospital Unknown status NCT03284801
6 Observational Prospective Multicentered Study Evaluating Initial Clinical Presentation of Inflammatory Optic Neuritis (ON) Associated or Not With Autoantibodies Anti- Myelin-oligodendrocyte-glycoprotein (MOG-Ab) Unknown status NCT03345537
7 Pediatric Multiple Sclerosis in Egypt. A Multi-center Registry of 186 Patients Completed NCT03360188
8 A Phase IV Study to Assess the Safety of Menveo Vaccine Being Used by HMO Subjects Aged 11-21 Years of Age Completed NCT01452464
9 PEDIATRIC SONICS: Pediatric Study of Neuropsychology and Imaging in CNS Demyelinating Syndromes. Recruiting NCT03942952
10 A Multicenter Observational Study to Evaluate Pediatric Multiple Sclerosis in Brazil Recruiting NCT03087136
11 Epidemiology and Prognosis of Encephalitis in Intensive Care Recruiting NCT02906631
12 Large-scale, Multi-disciplinary Sample and Data Repository for Multiple Sclerosis and Related Demyelinating Diseases Active, not recruiting NCT00445367

Search NIH Clinical Center for Acute Disseminated Encephalomyelitis

Genetic Tests for Acute Disseminated Encephalomyelitis

Anatomical Context for Acute Disseminated Encephalomyelitis

MalaCards organs/tissues related to Acute Disseminated Encephalomyelitis:

40
Brain, Spinal Cord, Heart, Thyroid, Lung, Bone, Eye

Publications for Acute Disseminated Encephalomyelitis

Articles related to Acute Disseminated Encephalomyelitis:

(show top 50) (show all 1621)
# Title Authors PMID Year
1
Doxycycline in autoimmune central nervous system disorders in children: an in vitro study. 54 61
17990580 2007
2
Hypersomnia and low cerebrospinal fluid hypocretin levels in acute disseminated encephalomyelitis. 54 61
15519122 2004
3
Structural similarity between the bee venom peptides and the immunodominant human myelin basic proteins: role for pathogenesis of acute disseminated encephalomyelitis. 54 61
12589368 2003
4
A case of acute disseminated encephalomyelitis presenting hypersomnia with decreased hypocretin level in cerebrospinal fluid. 54 61
12269735 2002
5
Heat shock protein immunoreactivity in CSF: correlation with oligoclonal banding and demyelinating disease. 54 61
7936289 1994
6
Overlapping autoimmune syndrome: A case of concomitant anti-NMDAR encephalitis and myelin oligodendrocyte glycoprotein (MOG) antibody disease. 61
31837635 2020
7
Variation in Treatment and Outcomes of Children With Acute Disseminated Encephalomyelitis. 61
31996356 2020
8
Acute Disseminated Encephalomyelitis followed by Optic Neuritis: A Rare Syndrome of Uncertain Treatment and Prognosis. 61
31935763 2020
9
Extensive subpial cortical demyelination is specific to multiple sclerosis. 61
31916298 2020
10
Acute disseminated encephalomyelitis (ADEM) associated with mosquito-borne diseases: Chikungunya virus X yellow fever immunization. 61
31994659 2020
11
Vanishing Pseudotumoral White Matter Lesions Presenting as Aphasia and Altered Mental Status in a 71-Year-Old Male. 61
31911876 2019
12
Evaluation of the underlying causes of papilledema in children. 61
31836094 2019
13
Whole exome sequencing in a child with acute disseminated encephalomyelitis, optic neuritis, and periodic fever syndrome: a case report. 61
31836009 2019
14
Herpes Simplex Virus 1 Induces Brain Inflammation and Multifocal Demyelination in the Cotton Rat Sigmodon hispidus. 61
31597775 2019
15
[Radiological and etiological features of acute disseminated encephalomyelitis in adults]. 61
31761605 2019
16
Relevance of antibodies to myelin oligodendrocyte glycoprotein in CSF of seronegative cases. 61
31645473 2019
17
Anti-myelin oligodendrocyte glycoprotein antibody-positive acute disseminated encephalomyelitis mimicking limbic encephalitis: A case report. 61
31733424 2019
18
Clinical spectrum of inflammatory central nervous system demyelinating disorders associated with antibodies against myelin oligodendrocyte glycoprotein. 61
30365980 2019
19
Efficacy of levofloxacin on macrolide-unresponsive and corticosteroid-resistant refractory Mycoplasma pneumoniae pneumonia in children. 61
31865723 2019
20
Neurosyphilis in the modern era: Literature review and case series. 61
31427238 2019
21
Atypical presentation of MOG-related disease: Slowly progressive behavioral and personality changes following a seizure. 61
31525625 2019
22
Atypical Pediatric Demyelinating Diseases of the Central Nervous System. 61
31773416 2019
23
Acute Hemorrhagic Leukoencephalopathy: Pathological Features and Cerebrospinal Fluid Cytokine Profiles. 61
31376926 2019
24
Acute Disseminated Encephalomyelitis in Children: An Updated Review Based on Current Diagnostic Criteria. 61
31371120 2019
25
18F-florbetapir PET/MRI for quantitatively monitoring demyelination and remyelination in acute disseminated encephalomyelitis. 61
31720882 2019
26
Acute disseminated encephalomyelitis in children - clinical and MRI decision making in the emergency department. 61
30846211 2019
27
School performance and psychiatric morbidity 6 years after pediatric acute disseminated encephalomyelitis: A nationwide population-based cohort study. 61
31655433 2019
28
Acute ataxia in children: Common causes and yield of diagnostic work-up in the era of varicella vaccination. 61
31327588 2019
29
The clinical value of complement proteins in differentiating AQP4-IgG-positive from MOG-IgG-positive neuromyelitis optica spectrum disorders. 61
31276911 2019
30
Dengue Fever with Acute Disseminated Encephalomyelitis : Sensorium Imbroglio. 61
31571462 2019
31
Post-vaccinial encephalomyelitis - Probable acute disseminated encephalomyelitis (ADEM) -: A case report. 61
31742183 2019
32
A unique case of multiphasic ADEM or what else? 61
31351264 2019
33
Comparison of Clinical Outcomes of Transverse Myelitis Among Adults With Myelin Oligodendrocyte Glycoprotein Antibody vs Aquaporin-4 Antibody Disease. 61
31596489 2019
34
A retrospective cohort study of plasma exchange in central nervous system demyelinating events in children. 61
31319355 2019
35
MOG antibody-associated encephalomyelitis/encephalitis. 61
30907249 2019
36
Diagnostic Considerations in Acute Disseminated Encephalomyelitis and the Interface with MOG Antibody. 61
31340401 2019
37
Acute Disseminated Encephalomyelitis (ADEM) and Increased Intracranial Pressure Associated With Anti-Myelin Oligodendrocyte Glycoprotein Antibodies. 61
31248672 2019
38
Pediatric acquired demyelinating syndrome (ADS) in inpatient hospital settings: The hospitalization rate, costs, and outcomes in the US. 61
31295724 2019
39
Serial Anti-Myelin Oligodendrocyte Glycoprotein Antibody Analyses and Outcomes in Children With Demyelinating Syndromes. 61
31545352 2019
40
Zika virus encephalitis in immunocompetent mice is dominated by innate immune cells and does not require T or B cells. 61
31511023 2019
41
Ratio of Alpha 2-Macroglobulin Levels in Cerebrospinal Fluid and Serum: An Expression of Neuroinflammation in Acute Disseminated Encephalomyelitis. 61
31248670 2019
42
Etiological Spectrum of Non-compressive Myelopathies in Tertiary Care Centre. 61
31561681 2019
43
Population-based Incidence of Pediatric and Adult Optic Neuritis and the Risk of Multiple Sclerosis. 61
31732227 2019
44
Serum neurofilament light chain in pediatric MS and other acquired demyelinating syndromes. 61
31383792 2019
45
Acute disseminated encephalomyelitis following varicella-zoster virus infection: Case report of effective treated both in clinical symptom and neuroimaging. 61
31342665 2019
46
Causes and Clinical Features of Childhood Encephalitis: A Multicenter, Prospective Cohort Study. 61
31549170 2019
47
MOG antibody seropositive aseptic meningitis: A new clinical phenotype. 61
31108402 2019
48
An Uncommon Diagnosis in a Child Presenting With Double Vision and Imbalance. 61
31335784 2019
49
Incidence of pediatric neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein antibody-associated disease in Denmark 2008‒2018: A nationwide, population-based cohort study. 61
31276927 2019
50
[Encephalitis caused by type B influenza virus in an adult. Report of one case]. 61
31859991 2019

Variations for Acute Disseminated Encephalomyelitis

Expression for Acute Disseminated Encephalomyelitis

Search GEO for disease gene expression data for Acute Disseminated Encephalomyelitis.

Pathways for Acute Disseminated Encephalomyelitis

Pathways related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.98 IL1B IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
2
Show member pathways
13.27 IL1B IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
3
Show member pathways
12.88 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B
4
Show member pathways
12.8 IL1B HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B
5 12.77 IL1B HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B
6
Show member pathways
12.6 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 CD40LG
7
Show member pathways
12.6 IL1B IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
8
Show member pathways
12.56 IL1B IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
9
Show member pathways
12.51 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B
10
Show member pathways
12.36 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 CD40LG
11 12.31 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B
12
Show member pathways
12.29 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
13
Show member pathways
12.16 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
14 12.12 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B
15 12.05 IL1B IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
16
Show member pathways
11.94 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
17 11.91 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
18 11.9 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 CDH23
19 11.81 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
20
Show member pathways
11.78 IL1B IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
21 11.77 IL1B HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
22
Show member pathways
11.74 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
23 11.72 IL1B IL10 CCR6
24 11.71 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
25 11.66 IL1B IL10 CCL4
26 11.63 IL1B HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 CSF3
27 11.6 IL1B CSF3 CCL4
28 11.51 IL1B IL10 CSF3 CD40LG
29 11.49 IL1B IL10 CSF3 CCL4
30 11.39 MPZ HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B
31 11.13 IL1B IL10 HLA-DRB1 CSF3
32 10.96 IL1B IL10 CSF3 CD40LG CCL4

GO Terms for Acute Disseminated Encephalomyelitis

Cellular components related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.92 MBP HLA-DRB1 HLA-DPA1 HLA-B CNTNAP2 CDH23
2 external side of plasma membrane GO:0009897 9.91 MOG HLA-DRB1 HLA-B CD40LG CCR6 AQP4
3 lysosome GO:0005764 9.89 MPZ IL1B HLA-DRB1 HLA-DQA1 HLA-DPA1
4 endosome membrane GO:0010008 9.88 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 AQP4
5 trans-Golgi network membrane GO:0032588 9.76 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
6 endocytic vesicle membrane GO:0030666 9.71 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
7 transport vesicle membrane GO:0030658 9.67 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
8 clathrin-coated endocytic vesicle membrane GO:0030669 9.56 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
9 MHC class II protein complex GO:0042613 9.46 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
10 ER to Golgi transport vesicle membrane GO:0012507 9.35 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B
11 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.02 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B

Biological processes related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell receptor signaling pathway GO:0050852 9.72 MOG HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
2 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.67 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
3 interferon-gamma-mediated signaling pathway GO:0060333 9.65 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B
4 positive regulation of T cell proliferation GO:0042102 9.63 IL1B HLA-DPA1 CD40LG
5 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.48 MBP IL10
6 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.46 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
7 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.43 HLA-DRB1 HLA-DQB1
8 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.4 HLA-DRB1 HLA-DQB1
9 immune response GO:0006955 9.4 MBP IL1B IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1
10 antigen processing and presentation GO:0019882 9.35 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B

Molecular functions related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.55 IL1B IL10 CSF3 CD40LG CCL4
2 MHC class II receptor activity GO:0032395 9.26 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
3 peptide antigen binding GO:0042605 9.02 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B

Sources for Acute Disseminated Encephalomyelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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