ADE
MCID: ACT049
MIFTS: 50

Acute Disseminated Encephalomyelitis (ADE)

Categories: Eye diseases, Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Acute Disseminated Encephalomyelitis

MalaCards integrated aliases for Acute Disseminated Encephalomyelitis:

Name: Acute Disseminated Encephalomyelitis 12 53 54 59 15 17
Acute Disseminated Encephalitis 12 59 72 33
Adem 12 53 59
Encephalomyelitis, Acute Disseminated 72
Encephalomyelitis Acute Disseminated 55
Ade 53

Characteristics:

Orphanet epidemiological data:

59
acute disseminated encephalomyelitis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



External Ids:

Disease Ontology 12 DOID:639
MeSH 44 D004673
NCIt 50 C34578
SNOMED-CT 68 83942000
ICD10 33 G04.0
ICD10 via Orphanet 34 G04.0
UMLS via Orphanet 73 C0014059
Orphanet 59 ORPHA83597
UMLS 72 C0014059 C3536864

Summaries for Acute Disseminated Encephalomyelitis

NINDS : 54 Acute disseminated encephalomyelitis (ADEM) is characterized by a brief but widespread attack of inflammation in the brain and spinal cord that damages myelin – the protective covering of nerve fibers.  ADEM often follows viral or bacterial infections, or less often, vaccination for measles, mumps, or rubella.  The symptoms of ADEM appear rapidly, beginning with encephalitis-like symptoms such as fever, fatigue, headache, nausea and vomiting, and in the most severe cases, seizures and coma.  ADEM typically damages white matter (brain tissue that takes its name from the white color of myelin), leading to neurological symptoms such as visual loss (due to inflammation of the optic nerve) in one or both eyes, weakness even to the point of paralysis, and difficulty coordinating voluntary muscle movements (such as those used in walking).  ADEM is sometimes misdiagnosed as a severe first attack of multiple sclerosis (MS), since the symptoms and the appearance of the white matter injury on brain imaging may be similar.  However, ADEM has several features which differentiate it from MS.  First, unlike MS patients, persons with ADEM will have rapid onset of fever, a history of recent infection or immunization, and some degree of impairment of consciousness, perhaps even coma; these features are not typically seen in MS.  Children are more likely than adults to have ADEM, whereas MS is a rare diagnosis in children.  In addition, ADEM usually consists of a single episode or attack of widespread myelin damage, while MS features many attacks over the course of time. Doctors will often use imaging techniques, such as MRI (magnetic resonance imaging), to search for old and new lesions (areas of damage) on the brain.  The presence of older brain lesions on MRI suggest that the condition may be MS rather than ADEM, since MS can cause brain lesions before symptoms become obvious.  In rare situations, a brain biopsy may be necessary to differentiate between ADEM and some other diseases that involve inflammation and damage to myelin.

MalaCards based summary : Acute Disseminated Encephalomyelitis, also known as acute disseminated encephalitis, is related to allergic encephalomyelitis and panencephalitis, subacute sclerosing. An important gene associated with Acute Disseminated Encephalomyelitis is MBP (Myelin Basic Protein), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Cytokine Signaling in Immune system. The drugs Antibodies, Blocking and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and eye.

Disease Ontology : 12 An encephalomyelitis characterized by inflammation locatedin brain and locatedin spinal cord that damages myelin. It usually occurs after viral infection, but also following vaccination, bacterial or parasitic infection.

NIH Rare Diseases : 53 Acute disseminated encephalomyelitis (ADEM) is a neurological condition characterized by a brief but intense attack of inflammation in the brain and spinal cord. This may lead to damage of the layer of insulation around the nerves (myelin) within affected areas. ADEM often follows viral infection, or less often, vaccinations for measles, mumps, or rubella (MMR). Symptoms usually appear rapidly, beginning with fever, fatigue, headache, nausea and vomiting. Treatment for ADEM is targeted at suppressing inflammation in the brain using anti-inflammatory drugs. Most people begin to recover within days, with total or near-total recovery within a few months. Some people may have lifelong neurological impairments, and very rarely, severe cases can be fatal.

Wikipedia : 75 Acute disseminated encephalomyelitis (ADEM), or acute demyelinating encephalomyelitis, is a rare... more...

Related Diseases for Acute Disseminated Encephalomyelitis

Diseases related to Acute Disseminated Encephalomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1724)
# Related Disease Score Top Affiliating Genes
1 allergic encephalomyelitis 33.1 MOG MBP
2 panencephalitis, subacute sclerosing 33.0 MOG MBP
3 pediatric multiple sclerosis 31.1 MOG HLA-DRB1 HLA-DQB1
4 neuritis 30.8 MOG MBP AQP4
5 acute transverse myelitis 30.8 IL10 AQP4
6 myelitis 30.8 MOG MBP AQP4
7 demyelinating disease 30.6 MOG MBP IL10 AQP4
8 viral encephalitis 30.6 MBP IL10
9 transverse myelitis 30.5 MBP IL10 AQP4
10 herpes zoster 30.5 IL10 HLA-B
11 intermediate uveitis 30.4 IL10 HLA-B
12 brain injury 30.4 MBP IL10
13 hematopoietic stem cell transplantation 30.4 IL10 HLA-B
14 pure red-cell aplasia 30.3 HLA-DRB1 HLA-DQB1
15 toxoplasmosis 30.3 IL10 HLA-DQB1 HLA-DQA1
16 alexia 30.2 MBP AQP4
17 optic nerve disease 30.1 MOG MBP AQP4
18 optic neuritis 30.1 MOG MBP HLA-DRB1 AQP4
19 rubella 30.0 MOG IL10 HLA-DRB1 HLA-DQB1 HLA-B
20 rheumatic fever 30.0 IL10 HLA-DRB1 HLA-DQA1
21 peripheral nervous system disease 30.0 MOG MBP AQP4
22 rheumatic disease 30.0 IL10 HLA-DRB1 HLA-B
23 endometritis 29.9 HLA-DQB1 HLA-DQA1
24 complex regional pain syndrome 29.9 IL10 HLA-B
25 hypersomnia 29.9 HLA-DRB1 HLA-DQB1 HCRT
26 dengue hemorrhagic fever 29.9 IL10 HLA-DRB1 HLA-B
27 neuroretinitis 29.8 MOG AQP4
28 polyradiculoneuropathy 29.8 MBP IL10 HLA-DRB1
29 congenital toxoplasmosis 29.7 HLA-DQB1 HLA-DQA1
30 graft-versus-host disease 29.7 IL10 HLA-DRB1 HLA-DQB1 HLA-B
31 nervous system disease 29.7 MOG MBP IL10 AQP4
32 microscopic colitis 29.6 HLA-DRB1 HLA-DQB1
33 traumatic brain injury 29.6 MBP IL10 AQP4
34 balo concentric sclerosis 29.6 MOG MBP AQP4
35 spondyloarthropathy 29.5 IL10 HLA-B
36 arthritis 29.5 IL10 HLA-DRB1 HLA-DQB1
37 guillain-barre syndrome 29.5 MBP HLA-DQB1 HLA-DQA1 HCRT
38 diabetes mellitus 29.4 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-B
39 autoimmune disease 29.3 MOG MBP IL10 HLA-DRB1 HLA-DQB1
40 relapsing-remitting multiple sclerosis 29.3 MOG MBP IL10 AQP4
41 sleep disorder 29.2 MOG HCRT
42 systemic lupus erythematosus 29.2 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
43 asthma 29.1 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1
44 multiple sclerosis 29.1 MOG MBP IL10 HLA-DRB1 HLA-DQB1 AQP4
45 central nervous system disease 29.0 MOG MBP HCRT AQP4
46 leishmaniasis 28.9 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1
47 rheumatoid arthritis 28.8 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-B
48 diabetes mellitus, insulin-dependent 28.7 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1
49 neuromyelitis optica 28.7 MOG MBP HLA-DRB1 HCRT AQP4
50 internuclear ophthalmoplegia 28.5 MOG MBP HCRT AQP4

Graphical network of the top 20 diseases related to Acute Disseminated Encephalomyelitis:



Diseases related to Acute Disseminated Encephalomyelitis

Symptoms & Phenotypes for Acute Disseminated Encephalomyelitis

Drugs & Therapeutics for Acute Disseminated Encephalomyelitis

Drugs for Acute Disseminated Encephalomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies, Blocking Phase 4
2 Vaccines Phase 4
3
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
4
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
5
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
6
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
7
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
8 Hormone Antagonists Phase 3
9 Hormones Phase 3
10 Antiemetics Phase 3
11 Neuroprotective Agents Phase 3
12 Gastrointestinal Agents Phase 3
13 Anti-Inflammatory Agents Phase 3
14 Methylprednisolone Acetate Phase 3
15 Peripheral Nervous System Agents Phase 3
16 glucocorticoids Phase 3
17 Prednisolone acetate Phase 3
18 Autonomic Agents Phase 3
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
20
rituximab Approved Phase 2 174722-31-7 10201696
21 Antibodies Phase 2
22 Immunoglobulins Phase 2
23 Immunologic Factors Phase 2
24 Antineoplastic Agents, Immunological Phase 2
25 Antirheumatic Agents Phase 2
26 Protective Agents
27 Adjuvants, Immunologic
28 Anti-Infective Agents
29 Radiation-Protective Agents
30 Anti-Bacterial Agents
31 Antibiotics, Antitubercular
32 interferons
33 Interferon Inducers
34 Antiviral Agents
35 polysaccharide-K
36 Autoantibodies

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Neutralizing Antibody Titers 6 Years After the Third Dose of Inactivated Japanese Encephalitis Vaccine and Projected Duration of Protection Completed NCT02039440 Phase 4
2 Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone Unknown status NCT00004645 Phase 3
3 Randomized Clinical Trial of Plasma Exchanges Versus Sham Plasma Exchanges in Disabling Multiple Sclerosis Acute Relapses Refractory to Steroid Treatment Completed NCT01442233 Phase 3
4 Prospective Assessment of Efficacy of Immunoadsorption Therapy in Managing Childhood NMDA-Receptor (NMDAR) Antibodies Encephalitis Not yet recruiting NCT03274375 Phase 2 IA session;Rituximab
5 Pediatric Multiple Sclerosis in Egypt. A Multi-center Registry of 186 Patients Completed NCT03360188
6 A Phase IV Study to Assess the Safety of Menveo Vaccine Being Used by HMO Subjects Aged 11-21 Years of Age Completed NCT01452464
7 A Multicenter Observational Study to Evaluate Pediatric Multiple Sclerosis in Brazil Recruiting NCT03087136
8 Epidemiology and Prognosis of Encephalitis in Intensive Care Recruiting NCT02906631
9 Large-scale, Multi-disciplinary Sample and Data Repository for Multiple Sclerosis and Related Demyelinating Diseases Active, not recruiting NCT00445367
10 PEDIATRIC SONICS: Pediatric Study of Neuropsychology and Imaging in CNS Demyelinating Syndromes. Not yet recruiting NCT03942952
11 Management of Acute Disseminated Encephalomyelitis in Neurology Unit of Assiut University Children Hospital Not yet recruiting NCT03284801
12 Observational Prospective Multicentered Study Evaluating Initial Clinical Presentation of Inflammatory Optic Neuritis (ON) Associated or Not With Autoantibodies Anti- Myelin-oligodendrocyte-glycoprotein (MOG-Ab) Not yet recruiting NCT03345537

Search NIH Clinical Center for Acute Disseminated Encephalomyelitis

Genetic Tests for Acute Disseminated Encephalomyelitis

Anatomical Context for Acute Disseminated Encephalomyelitis

MalaCards organs/tissues related to Acute Disseminated Encephalomyelitis:

41
Brain, Spinal Cord, Eye, T Cells, Bone, Bone Marrow, B Cells

Publications for Acute Disseminated Encephalomyelitis

Articles related to Acute Disseminated Encephalomyelitis:

(show top 50) (show all 1587)
# Title Authors PMID Year
1
Doxycycline in autoimmune central nervous system disorders in children: an in vitro study. 9 38
17990580 2007
2
Hypersomnia and low cerebrospinal fluid hypocretin levels in acute disseminated encephalomyelitis. 9 38
15519122 2004
3
Structural similarity between the bee venom peptides and the immunodominant human myelin basic proteins: role for pathogenesis of acute disseminated encephalomyelitis. 9 38
12589368 2003
4
A case of acute disseminated encephalomyelitis presenting hypersomnia with decreased hypocretin level in cerebrospinal fluid. 9 38
12269735 2002
5
Heat shock protein immunoreactivity in CSF: correlation with oligoclonal banding and demyelinating disease. 9 38
7936289 1994
6
MOG antibody seropositive aseptic meningitis: A new clinical phenotype. 38
31108402 2019
7
Neurosyphilis in the modern era: Literature review and case series. 38
31427238 2019
8
An Uncommon Diagnosis in a Child Presenting With Double Vision and Imbalance. 38
31335784 2019
9
Incidence of pediatric neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein antibody-associated disease in Denmark 2008‒2018: A nationwide, population-based cohort study. 38
31276927 2019
10
Serum neurofilament light chain in pediatric MS and other acquired demyelinating syndromes. 38
31383792 2019
11
Acute ataxia in children: Common causes and yield of diagnostic work-up in the era of varicella vaccination. 38
31327588 2019
12
A unique case of multiphasic ADEM or what else? 38
31351264 2019
13
A retrospective cohort study of plasma exchange in central nervous system demyelinating events in children. 38
31319355 2019
14
Myelin in the Central Nervous System: Structure, Function, and Pathology. 38
31066630 2019
15
Acute disseminated encephalomyelitis following varicella-zoster virus infection: Case report of effective treated both in clinical symptom and neuroimaging. 38
31342665 2019
16
Callosal lesions on magnetic resonance imaging with multiple sclerosis, neuromyelitis optica spectrum disorder and acute disseminated encephalomyelitis. 38
31030018 2019
17
Acute Disseminated Encephalomyelitis in Children: An Updated Review Based on Current Diagnostic Criteria. 38
31371120 2019
18
Diagnostic Considerations in Acute Disseminated Encephalomyelitis and the Interface with MOG Antibody. 38
31340401 2019
19
Pediatric acquired demyelinating syndrome (ADS) in inpatient hospital settings: The hospitalization rate, costs, and outcomes in the US. 38
31295724 2019
20
A case of ADEM-like presentation with anti-MOG antibody following tumefactive demyelinating lesion. 38
30933712 2019
21
Clinical characteristics and prognosis of myelin oligodendrocyte glycoprotein antibody-seropositive paediatric optic neuritis in China. 38
30049802 2019
22
Neuromyelitis Optica Spectrum Disorder and Anti-MOG Syndromes. 38
31212763 2019
23
The clinical value of complement proteins in differentiating AQP4-IgG-positive from MOG-IgG-positive neuromyelitis optica spectrum disorders. 38
31276911 2019
24
Differential Diagnosis of Pediatric Multiple Sclerosis. 38
31163654 2019
25
Neurogenic lower urinary tract dysfunction in multiple sclerosis, neuromyelitis optica, and related disorders. 38
30076494 2019
26
Acute Hemorrhagic Leukoencephalopathy: Pathological Features and Cerebrospinal Fluid Cytokine Profiles. 38
31376926 2019
27
Clinical time course of pediatric acute disseminated encephalomyelitis. 38
30833092 2019
28
Low bone marrow signal on T1-weighted magnetic resonance imaging in a 2-year-old patient with acute disseminated encephalomyelitis. 38
31242538 2019
29
Pseudotumoral demyelinating lesions: diagnostic approach and long-term outcome. 38
30844860 2019
30
A Nationwide Survey of Pediatric-onset Japanese Encephalitis in Japan. 38
30252025 2019
31
Acute Disseminated Encephalomyelitis After Chikungunya Infection. 38
30830174 2019
32
The clinical spectrum and incidence of anti-MOG-associated acquired demyelinating syndromes in children and adults. 38
31094288 2019
33
Clinical characteristics of myelin oligodendrocyte glycoprotein antibody neuromyelitis optica spectrum disorder. 38
30825703 2019
34
Retinal haemorrhage in a child with optic neuritis and acute disseminated encephalomyelitis. 38
31061175 2019
35
Clinical characteristics and outcomes of myelin oligodendrocyte glycoprotein antibody-seropositive optic neuritis in varying age groups: A cohort study in China. 38
30904690 2019
36
Isolated seizures during the first episode of relapsing myelin oligodendrocyte glycoprotein antibody-associated demyelination in children. 38
30221764 2019
37
Acute disseminated encephalomyelitis due to abrus precatorius poisoning - A case report. 38
31249468 2019
38
Ratio of Alpha 2-Macroglobulin Levels in Cerebrospinal Fluid and Serum: An Expression of Neuroinflammation in Acute Disseminated Encephalomyelitis. 38
31248670 2019
39
New onset transverse myelitis diagnostic accuracy and patient experiences. 38
30738277 2019
40
Acute disseminated encephalomyelitis due to JC virus infection as the onset of non-Hodgkin's lymphoma. 38
30337110 2019
41
Inflammatory demyelinating diseases of the central nervous system in Niger. 38
30270137 2019
42
Fulminant acute disseminated encephalomyelitis in children. 38
30522797 2019
43
Clinical Presentation and outcome of acute disseminated encephalomyelitis in Saudi Arabia. Tertiary Center Experience. 38
31056539 2019
44
Spectrum of neurological complications in chikungunya fever: experience at a tertiary care centre and review of literature. 38
30678544 2019
45
Early Recognition and Treatment of Acute Disseminated Encephalomyelitis in Pediatrics: A Case Series. 38
30973501 2019
46
Delayed appearance of transient hyperintensity foci on T1-weighted magnetic resonance imaging in acute disseminated encephalomyelitis. 38
30671706 2019
47
[Acute disseminated encephalomyelitis due to Mycoplasma pneumoniae in a previously healthy boy]. 38
30236414 2019
48
Brain MRI Findings in Pediatric-Onset Neuromyelitis Optica Spectrum Disorder: Challenges in Differentiation from Acute Disseminated Encephalomyelitis. 38
30846436 2019
49
Acute disseminated encephalomyelitis in an older adult following prostate resection. 38
30619950 2019
50
Acute disseminated encephalomyelitis, a rare post-malaria neurological complication: Case report and review of the literature. 38
29574241 2019

Variations for Acute Disseminated Encephalomyelitis

Expression for Acute Disseminated Encephalomyelitis

Search GEO for disease gene expression data for Acute Disseminated Encephalomyelitis.

Pathways for Acute Disseminated Encephalomyelitis

Pathways related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.2 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B
2
Show member pathways
13.19 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B
3
Show member pathways
12.84 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B
4
Show member pathways
12.7 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
5
Show member pathways
12.67 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B
6
Show member pathways
12.5 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
7
Show member pathways
12.47 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
8
Show member pathways
12.4 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B
9
Show member pathways
12.28 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
10
Show member pathways
12.24 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
11 12.14 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B
12
Show member pathways
12.11 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
13
Show member pathways
11.99 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
14 11.91 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
15
Show member pathways
11.86 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
16
Show member pathways
11.84 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
17 11.84 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
18 11.81 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
19 11.76 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
20 11.74 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B
21 11.7 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
22 11.52 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
23 11.52 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B
24 11.48 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
25 11.08 IL10 HLA-DRB1
26 11 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1

GO Terms for Acute Disseminated Encephalomyelitis

Cellular components related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.92 HLA-DRB1 HLA-DQA1 HLA-DPA1 HLA-B HCRT
2 Golgi membrane GO:0000139 9.85 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B
3 cell surface GO:0009986 9.81 MBP HLA-DRB1 HLA-DPA1 HLA-B
4 lysosomal membrane GO:0005765 9.78 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
5 endosome membrane GO:0010008 9.73 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
6 trans-Golgi network membrane GO:0032588 9.71 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
7 endocytic vesicle membrane GO:0030666 9.67 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
8 transport vesicle membrane GO:0030658 9.62 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
9 clathrin-coated endocytic vesicle membrane GO:0030669 9.56 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
10 MHC class II protein complex GO:0042613 9.46 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
11 ER to Golgi transport vesicle membrane GO:0012507 9.35 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B
12 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.02 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B
13 plasma membrane GO:0005886 10.1 MOG MBP HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1

Biological processes related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.8 MBP IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
2 immune system process GO:0002376 9.78 HLA-DRB1 HLA-DQA1 HLA-DPA1 HLA-B
3 T cell receptor signaling pathway GO:0050852 9.72 MOG HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
4 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.67 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
5 interferon-gamma-mediated signaling pathway GO:0060333 9.55 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B
6 negative regulation of T cell proliferation GO:0042130 9.51 IL10 HLA-DRB1
7 negative regulation of interferon-gamma production GO:0032689 9.49 IL10 HLA-DRB1
8 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.46 MBP IL10
9 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.43 HLA-DRB1 HLA-DQB1
10 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.4 HLA-DRB1 HLA-DQB1
11 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.26 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
12 antigen processing and presentation GO:0019882 9.02 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B

Molecular functions related to Acute Disseminated Encephalomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 9.26 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1
2 peptide antigen binding GO:0042605 9.02 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-DPA1 HLA-B

Sources for Acute Disseminated Encephalomyelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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