MCID: ACT069
MIFTS: 21

Acute Endometritis

Categories: Reproductive diseases

Aliases & Classifications for Acute Endometritis

MalaCards integrated aliases for Acute Endometritis:

Name: Acute Endometritis 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:7528
NCIt 51 C27022
SNOMED-CT 69 67667007
UMLS 74 C0238103

Summaries for Acute Endometritis

Disease Ontology : 12 An endometritis that is characterized by onset within the past 1 - 3 days.

MalaCards based summary : Acute Endometritis is related to acute gonococcal endometritis and endometritis. An important gene associated with Acute Endometritis is NLRC5 (NLR Family CARD Domain Containing 5), and among its related pathways/superpathways are Vascular smooth muscle contraction and Arachidonic acid metabolism. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Acute Endometritis

Diseases in the Endometritis family:

Acute Endometritis

Diseases related to Acute Endometritis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 acute gonococcal endometritis 11.2
2 endometritis 10.1
3 haemophilus influenzae 9.9
4 endometrial disease 9.7 NLRC5 PTGS2

Symptoms & Phenotypes for Acute Endometritis

GenomeRNAi Phenotypes related to Acute Endometritis according to GeneCards Suite gene sharing:

27 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.55 GLS PTGS2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.55 PTGS2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.55 GLS PTGS2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-141 9.55 GLS
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-15 9.55 GLS
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.55 GLS
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.55 PTGS2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 9.55 GLS
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.55 GLS PTGS2
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.55 GLS
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.55 GLS PTGS2
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.55 GLS
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-98 9.55 PTGS2

Drugs & Therapeutics for Acute Endometritis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Role of Novel Organisms in Acute Endometritis Completed NCT01236131

Search NIH Clinical Center for Acute Endometritis

Genetic Tests for Acute Endometritis

Anatomical Context for Acute Endometritis

Publications for Acute Endometritis

Articles related to Acute Endometritis:

# Title Authors Year
1
Haemophilus influenzae acute endometritis with bacteremia: case report and literature review. ( 23537790 )
2013
2
Association between Mycoplasma genitalium and acute endometritis. ( 11888591 )
2002
3
Morphologic evaluation of acute endometritis in mares with differing resistance to uterine infections. ( 3565199 )
1986

Variations for Acute Endometritis

Expression for Acute Endometritis

Search GEO for disease gene expression data for Acute Endometritis.

Pathways for Acute Endometritis

Pathways related to Acute Endometritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.26 PLA2G10 PTGIR PTGS2
2
Show member pathways
11.67 PTGIS PTGS2
3
Show member pathways
11.5 PLA2G10 PTGIS PTGS2
4 11.1 PTGIR PTGIS PTGS2
5
Show member pathways
10.84 PTGIS PTGS2
6 10.75 PTGIS PTGS2
7 10.68 PTGIS PTGS2
8 10.61 PTGIR PTGIS PTGS2
9 10.25 PTGIR PTGIS PTGS2

GO Terms for Acute Endometritis

Cellular components related to Acute Endometritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 caveola GO:0005901 8.62 PTGIS PTGS2

Biological processes related to Acute Endometritis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.63 PLA2G10 PTGIS PTGS2
2 fatty acid metabolic process GO:0006631 9.49 PTGIS PTGS2
3 cellular response to hypoxia GO:0071456 9.48 PTGIS PTGS2
4 negative regulation of NF-kappaB transcription factor activity GO:0032088 9.43 NLRC5 PTGIS
5 fatty acid biosynthetic process GO:0006633 9.4 PTGIS PTGS2
6 embryo implantation GO:0007566 9.37 PTGIS PTGS2
7 decidualization GO:0046697 9.32 PTGIS PTGS2
8 prostaglandin metabolic process GO:0006693 9.26 PTGIS PTGS2
9 prostaglandin biosynthetic process GO:0001516 9.16 PTGIS PTGS2
10 NAD biosynthesis via nicotinamide riboside salvage pathway GO:0034356 8.96 PTGIS PTGS2
11 cyclooxygenase pathway GO:0019371 8.62 PTGIS PTGS2

Molecular functions related to Acute Endometritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 8.62 PTGIS PTGS2

Sources for Acute Endometritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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