MCID: ACT047
MIFTS: 28

Acute Endophthalmitis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Acute Endophthalmitis

MalaCards integrated aliases for Acute Endophthalmitis:

Name: Acute Endophthalmitis 12 59 15 73

Characteristics:

Orphanet epidemiological data:

59
acute endophthalmitis
Inheritance: Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 59  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:11752
ICD9CM 35 360.01
SNOMED-CT 68 1493002 193268004
Orphanet 59 ORPHA279888
UMLS via Orphanet 74 C0154773
ICD10 via Orphanet 34 H44.0 H44.1
UMLS 73 C0154773

Summaries for Acute Endophthalmitis

MalaCards based summary : Acute Endophthalmitis is related to endophthalmitis and cataract. An important gene associated with Acute Endophthalmitis is IVD (Isovaleryl-CoA Dehydrogenase). The drugs Betamethasone and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include eye, and related phenotype is vision/eye.

Related Diseases for Acute Endophthalmitis

Diseases in the Endophthalmitis family:

Chronic Endophthalmitis Acute Endophthalmitis

Diseases related to Acute Endophthalmitis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 endophthalmitis 10.5
2 cataract 10.3
3 spinal disease 9.9 IVD VEGFA
4 endocarditis 9.6
5 immunoglobulin alpha deficiency 9.5 C4A TOR1A
6 kleine-levin hibernation syndrome 9.2 TOR1A TOR1B
7 purulent endophthalmitis 6.6 C4A IVD NDUFS4 SAMHD1 TOR1A TOR1B

Comorbidity relations with Acute Endophthalmitis via Phenotypic Disease Network (PDN):


Hypopyon Purulent Endophthalmitis

Graphical network of the top 20 diseases related to Acute Endophthalmitis:



Diseases related to Acute Endophthalmitis

Symptoms & Phenotypes for Acute Endophthalmitis

MGI Mouse Phenotypes related to Acute Endophthalmitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 8.92 IVD NDUFS4 TOR1A VEGFA

Drugs & Therapeutics for Acute Endophthalmitis

Drugs for Acute Endophthalmitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Betamethasone Approved, Vet_approved Phase 3 378-44-9 9782
2
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
3 Estradiol valerate Approved, Investigational, Vet_approved Phase 3 979-32-8
4
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
5
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
6
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
7
Polyestradiol phosphate Approved Phase 3 28014-46-2
8 Anti-Asthmatic Agents Phase 3
9 Anti-Bacterial Agents Phase 3
10 Antibiotics, Antitubercular Phase 3
11 Anti-Infective Agents Phase 3
12 Anti-Inflammatory Agents Phase 3
13 Antitubercular Agents Phase 3
14 Betamethasone benzoate Phase 3
15 Betamethasone sodium phosphate Phase 3
16 Betamethasone Valerate Phase 3 2152-44-5
17 Betamethasone-17,21-dipropionate Phase 3
18 glucocorticoids Phase 3
19 Hormone Antagonists Phase 3
20 Hormones Phase 3
21 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
22 Respiratory System Agents Phase 3
23 Contraceptive Agents Phase 3
24 Contraceptives, Oral Phase 3
25 Contraceptives, Oral, Combined Phase 3
26 Estradiol 17 beta-cypionate Phase 3
27 Estradiol 3-benzoate Phase 3
28 Fluoroquinolones Phase 3
29 Norgestimate, ethinyl estradiol drug combination Phase 3
30 Nucleic Acid Synthesis Inhibitors Phase 3
31 Topoisomerase Inhibitors Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Interest of Intravitreal Corticotherapy as the First-line Treatment for Post-operative Endophthalmitis Unknown status NCT01768078 Phase 3
2 Evaluation of Efficacy and Safety of Intracameral Moxifloxacin for Prevention of Postcataract Endophthalmitis. Terminated NCT02770729 Phase 3 Moxifloxacin;No injection of moxifloxacin
3 Targeted PCR and Acute Endophthalmitis Unknown status NCT02850653 Not Applicable

Search NIH Clinical Center for Acute Endophthalmitis

Genetic Tests for Acute Endophthalmitis

Anatomical Context for Acute Endophthalmitis

MalaCards organs/tissues related to Acute Endophthalmitis:

41
Eye

Publications for Acute Endophthalmitis

Articles related to Acute Endophthalmitis:

(show top 50) (show all 53)
# Title Authors Year
1
Utility of MALDI-TOF mass spectrometry in an outbreak investigation of acute endophthalmitis following intravitreal injection. ( 29605188 )
2018
2
Comparison of methods for identifying causative bacterial microorganisms in presumed acute endophthalmitis: conventional culture, blood culture, and PCR. ( 28222703 )
2017
3
Acute Endophthalmitis Caused by<i>Leuconostoc</i>spp. following Intravitreal Bevacizumab Injection. ( 29282402 )
2017
4
Acute endophthalmitis after cataract surgery: 164 consecutive cases treated at a referral center in South Korea. ( 28548647 )
2017
5
UTILITY OF INTRAOPERATIVE OPTICAL COHERENCE TOMOGRAPHY IN ACUTE ENDOPHTHALMITIS. ( 28858193 )
2017
6
Incidence of acute endophthalmitis after office based intravitreal bevacizumab injection. ( 29256542 )
2017
7
Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery. ( 28192644 )
2017
8
Adjunctive steroid therapy versus antibiotics alone for acute endophthalmitis after intraocular procedure. ( 28225198 )
2017
9
Perioperative Antibiotics to Prevent Acute Endophthalmitis after Ophthalmic Surgery: A Systematic Review and Meta-Analysis. ( 27824933 )
2016
10
25-GAUGE TROCAR CANNULA FOR ACUTE ENDOPHTHALMITIS-RELATED IN-OFFICE VITREOUS TAP AND INJECTION: Patient Comfort and Physician Ease of Use. ( 27471824 )
2016
11
Intravitreal dexamethasone in the management of acute endophthalmitis: a comparative retrospective study. ( 27646336 )
2016
12
TWO CASES OF ACUTE ENDOPHTHALMITIS AFTER INTRAVITREAL DEXAMETHASONE IMPLANT INJECTION. ( 26426482 )
2015
13
Clinical analysis of 23-gauge vitrectomy for the treatment of acute endophthalmitis after cataract surgery. ( 25837637 )
2015
14
Bilateral acute endophthalmitis associated with munchausen syndrome. ( 25799076 )
2015
15
Evidence for and against intravitreous corticosteroids in addition to intravitreous antibiotics for acute endophthalmitis. ( 24613894 )
2014
16
Incidence of acute endophthalmitis after intravitreal bevacizumab injection in a single clinical center. ( 23400076 )
2013
17
Acute endophthalmitis after intravitreal injection and preventive effect of preoperative topical antibiotics. ( 24067061 )
2013
18
Risk factors for acute endophthalmitis following cataract surgery: a systematic review and meta-analysis. ( 23990980 )
2013
19
Two rare cases of Acremonium acute endophthalmitis after cataract surgery in a tertiary care hospital. ( 24177307 )
2013
20
Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery. ( 23857416 )
2013
21
An outbreak of forty five cases of Pseudomonas aeruginosa acute endophthalmitis after phacoemulsification. ( 23471330 )
2012
22
Case control analyses of acute endophthalmitis after cataract surgery in South India associated with technique, patient care, and socioeconomic status. ( 22523647 )
2012
23
Streptococcus dysgalactiae endocarditis presenting as acute endophthalmitis. ( 24470923 )
2012
24
Acute endophthalmitis after cataract surgery at a referral centre in Northern Taiwan: review of the causative organisms, antibiotic susceptibility, and clinical features. ( 21252955 )
2011
25
Unusual acute endophthalmitis due to an as yet unclassified Acinetobacter gyllenbergii-like isolate. ( 21459914 )
2011
26
Acute endophthalmitis following 23-gauge sutureless transconjunctival vitrectomy. ( 21350291 )
2011
27
Acute endophthalmitis after cataract surgery: 250 consecutive cases treated at a tertiary referral center in the Netherlands. ( 20053391 )
2010
28
Acute endophthalmitis after cataract surgery at a referral centre in Northern Taiwan: review of the causative organisms, antibiotic susceptibility, and clinical features. ( 20379208 )
2010
29
Risk factors for acute endophthalmitis after cataract surgery: a population-based study. ( 19091417 )
2009
30
Postcataract acute endophthalmitis in France: national prospective survey. ( 19101430 )
2009
31
Incidence and visual outcome of acute endophthalmitis after cataract surgery--the experience of an eye department in Scotland. ( 19211606 )
2009
32
Acute endophthalmitis caused by Staphylococcus lugdunesis after intravitreal bevacizumab (Avastin) injection. ( 18528639 )
2009
33
Pars plana vitrectomy and silicone oil tamponade for acute endophthalmitis treatment. ( 19347118 )
2009
34
Incidence and management of acute endophthalmitis after intravitreal bevacizumab (Avastin) injection. ( 19218994 )
2009
35
Visual outcome and bacterial sensitivity after methicillin-resistant Staphylococcus aureus-associated acute endophthalmitis. ( 18191097 )
2008
36
Influence of intraocular lens material on the development of acute endophthalmitis after cataract surgery? ( 16980932 )
2008
37
Intraocular pharmacokinetics of intravenously administered marbofloxacin in rabbits with experimentally induced acute endophthalmitis. ( 18312141 )
2008
38
Adjunctive intravitreal dexamethasone in the treatment of acute endophthalmitis following cataract surgery. ( 19668397 )
2008
39
Acute endophthalmitis following intravitreal bevacizumab (Avastin) injection. ( 17277758 )
2007
40
Acute endophthalmitis after 25-gauge sutureless vitrectomy. ( 17492400 )
2007
41
Incidence of acute endophthalmitis following penetrating keratoplasty: a systematic review. ( 15883278 )
2005
42
Acute endophthalmitis incidence: intravitreal triamcinolone. ( 16087840 )
2005
43
Low acute endophthalmitis rate: possible explanations. ( 15975480 )
2005
44
Acute endophthalmitis following cataract surgery: a systematic review of the literature. ( 15883279 )
2005
45
Acute endophthalmitis following intravitreal triamcinolone acetonide injection. ( 15183833 )
2004
46
Incidence of acute endophthalmitis after triamcinolone-assisted pars plana vitrectomy. ( 15234294 )
2004
47
The epidemiology of acute endophthalmitis after cataract surgery in an Asian population. ( 15051201 )
2004
48
Risk factors of acute endophthalmitis after cataract extraction: a case-control study in Asian eyes. ( 14693767 )
2004
49
Acute endophthalmitis following intravitreal triamcinolone acetonide injection. ( 15183822 )
2004
50
Vitrectomy and silicone oil in the treatment of acute endophthalmitis. Preliminary results. ( 12879720 )
2003

Variations for Acute Endophthalmitis

Expression for Acute Endophthalmitis

Search GEO for disease gene expression data for Acute Endophthalmitis.

Pathways for Acute Endophthalmitis

GO Terms for Acute Endophthalmitis

Cellular components related to Acute Endophthalmitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule GO:0030141 8.96 TOR1A VEGFA
2 endoplasmic reticulum lumen GO:0005788 8.8 C4A TOR1A TOR1B

Biological processes related to Acute Endophthalmitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chaperone cofactor-dependent protein refolding GO:0051085 8.96 TOR1A TOR1B
2 nuclear membrane organization GO:0071763 8.62 TOR1A TOR1B

Sources for Acute Endophthalmitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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