MCID: ACT047
MIFTS: 33

Acute Endophthalmitis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Acute Endophthalmitis

MalaCards integrated aliases for Acute Endophthalmitis:

Name: Acute Endophthalmitis 12 60 15 74

Characteristics:

Orphanet epidemiological data:

60
acute endophthalmitis
Inheritance: Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 60  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:11752
ICD9CM 36 360.01
SNOMED-CT 69 1493002
ICD10 via Orphanet 35 H44.0 H44.1
UMLS via Orphanet 75 C0154773
Orphanet 60 ORPHA279888
UMLS 74 C0154773

Summaries for Acute Endophthalmitis

MalaCards based summary : Acute Endophthalmitis is related to endophthalmitis and cataract. An important gene associated with Acute Endophthalmitis is IVD (Isovaleryl-CoA Dehydrogenase), and among its related pathways/superpathways are Pertussis and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Betamethasone and Ethinyl Estradiol have been mentioned in the context of this disorder. Affiliated tissues include eye and temporal lobe, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Acute Endophthalmitis

Graphical network of the top 20 diseases related to Acute Endophthalmitis:



Diseases related to Acute Endophthalmitis

Symptoms & Phenotypes for Acute Endophthalmitis

GenomeRNAi Phenotypes related to Acute Endophthalmitis according to GeneCards Suite gene sharing:

27 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.7 IVD
2 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.7 C4A C4B
3 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.7 IVD
4 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.7 C4A C4B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.7 C4A C4B
6 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.7 C4A C4B
7 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.7 C4A C4B
8 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.7 C4A C4B
9 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.7 IVD
10 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.7 IVD
11 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.7 C4A C4B
12 Increased shRNA abundance (Z-score > 2) GR00366-A-5 9.7 IVD
13 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.7 C4A C4B
14 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.7 C4A C4B IVD

MGI Mouse Phenotypes related to Acute Endophthalmitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.02 IVD NDUFS4 NR2E3 TOR1A VEGFA

Drugs & Therapeutics for Acute Endophthalmitis

Drugs for Acute Endophthalmitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Betamethasone Approved, Vet_approved Phase 3 378-44-9 9782
2
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
3
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
4
Polyestradiol phosphate Approved Phase 3 28014-46-2
5
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
6
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
7 Antitubercular Agents Phase 3
8 Betamethasone Valerate Phase 3 2152-44-5
9 Antibiotics, Antitubercular Phase 3
10 glucocorticoids Phase 3
11 Anti-Bacterial Agents Phase 3
12 Anti-Inflammatory Agents Phase 3
13 Respiratory System Agents Phase 3
14 Betamethasone-17,21-dipropionate Phase 3
15 Betamethasone benzoate Phase 3
16 Hormones Phase 3
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
18 Anti-Asthmatic Agents Phase 3
19 Hormone Antagonists Phase 3
20 Betamethasone sodium phosphate Phase 3
21 Anti-Infective Agents Phase 3
22 Norgestimate, ethinyl estradiol drug combination Phase 3
23 Contraceptives, Oral Phase 3
24 Estradiol 3-benzoate Phase 3
25 Contraceptives, Oral, Combined Phase 3
26 Estradiol 17 beta-cypionate Phase 3
27 Contraceptive Agents Phase 3
28 Topoisomerase Inhibitors Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Interest of Intravitreal Corticotherapy as the First-line Treatment for Post-operative Endophthalmitis Completed NCT01768078 Phase 3
2 Evaluation of Efficacy and Safety of Intracameral Moxifloxacin for Prevention of Postcataract Endophthalmitis. Terminated NCT02770729 Phase 3 Moxifloxacin;No injection of moxifloxacin
3 Targeted PCR and Acute Endophthalmitis Unknown status NCT02850653 Not Applicable

Search NIH Clinical Center for Acute Endophthalmitis

Genetic Tests for Acute Endophthalmitis

Anatomical Context for Acute Endophthalmitis

MalaCards organs/tissues related to Acute Endophthalmitis:

42
Eye, Temporal Lobe

Publications for Acute Endophthalmitis

Articles related to Acute Endophthalmitis:

(show top 50) (show all 59)
# Title Authors Year
1
Physical Incompatibility between Vancomycin and Viscoelastic Mimicking Acute Endophthalmitis: The First Report. ( 30863651 )
2019
2
Utility of MALDI-TOF mass spectrometry in an outbreak investigation of acute endophthalmitis following intravitreal injection. ( 29605188 )
2018
3
Association of Acute Endophthalmitis With Intravitreal Injections of Corticosteroids or Anti-Vascular Growth Factor Agents in a Nationwide Study in France. ( 30242325 )
2018
4
Aspergillus aortitis in an immunocompetent patient presenting with acute endophthalmitis. ( 30344969 )
2018
5
Emergency management: acute endophthalmitis. ( 30487688 )
2018
6
Acute Endophthalmitis after Intravitreal Bevacizumab Injections at The Tertiary Centre in Nepal. ( 31056587 )
2018
7
Intravitreal dexamethasone in the management of acute endophthalmitis: a comparative retrospective study. ( 27646336 )
2017
8
Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery. ( 28192644 )
2017
9
Comparison of methods for identifying causative bacterial microorganisms in presumed acute endophthalmitis: conventional culture, blood culture, and PCR. ( 28222703 )
2017
10
Adjunctive steroid therapy versus antibiotics alone for acute endophthalmitis after intraocular procedure. ( 28225198 )
2017
11
Acute endophthalmitis after cataract surgery: 164 consecutive cases treated at a referral center in South Korea. ( 28548647 )
2017
12
UTILITY OF INTRAOPERATIVE OPTICAL COHERENCE TOMOGRAPHY IN ACUTE ENDOPHTHALMITIS. ( 28858193 )
2017
13
Incidence of acute endophthalmitis after office based intravitreal bevacizumab injection. ( 29256542 )
2017
14
Acute Endophthalmitis Caused by Leuconostoc spp. following Intravitreal Bevacizumab Injection. ( 29282402 )
2017
15
25-GAUGE TROCAR CANNULA FOR ACUTE ENDOPHTHALMITIS-RELATED IN-OFFICE VITREOUS TAP AND INJECTION: Patient Comfort and Physician Ease of Use. ( 27471824 )
2017
16
Perioperative Antibiotics to Prevent Acute Endophthalmitis after Ophthalmic Surgery: A Systematic Review and Meta-Analysis. ( 27824933 )
2016
17
TWO CASES OF ACUTE ENDOPHTHALMITIS AFTER INTRAVITREAL DEXAMETHASONE IMPLANT INJECTION. ( 26426482 )
2016
18
Clinical analysis of 23-gauge vitrectomy for the treatment of acute endophthalmitis after cataract surgery. ( 25837637 )
2015
19
Bilateral acute endophthalmitis associated with munchausen syndrome. ( 25799076 )
2015
20
Evidence for and against intravitreous corticosteroids in addition to intravitreous antibiotics for acute endophthalmitis. ( 24613894 )
2014
21
Risk factors for acute endophthalmitis following cataract surgery: a systematic review and meta-analysis. ( 23990980 )
2013
22
Acute endophthalmitis after intravitreal injection and preventive effect of preoperative topical antibiotics. ( 24067061 )
2013
23
Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery. ( 23857416 )
2013
24
Two rare cases of Acremonium acute endophthalmitis after cataract surgery in a tertiary care hospital. ( 24177307 )
2013
25
Incidence of acute endophthalmitis after intravitreal bevacizumab injection in a single clinical center. ( 23400076 )
2013
26
Streptococcus dysgalactiae endocarditis presenting as acute endophthalmitis. ( 24470923 )
2012
27
An outbreak of forty five cases of Pseudomonas aeruginosa acute endophthalmitis after phacoemulsification. ( 23471330 )
2012
28
Case control analyses of acute endophthalmitis after cataract surgery in South India associated with technique, patient care, and socioeconomic status. ( 22523647 )
2012
29
Unusual acute endophthalmitis due to an as yet unclassified Acinetobacter gyllenbergii-like isolate. ( 21459914 )
2011
30
Acute endophthalmitis following 23-gauge sutureless transconjunctival vitrectomy. ( 21350291 )
2011
31
Acute endophthalmitis after cataract surgery at a referral centre in Northern Taiwan: review of the causative organisms, antibiotic susceptibility, and clinical features. ( 21252955 )
2011
32
Acute endophthalmitis after cataract surgery at a referral centre in Northern Taiwan: review of the causative organisms, antibiotic susceptibility, and clinical features. ( 20379208 )
2010
33
Acute endophthalmitis after cataract surgery: 250 consecutive cases treated at a tertiary referral center in the Netherlands. ( 20053391 )
2010
34
Incidence and visual outcome of acute endophthalmitis after cataract surgery--the experience of an eye department in Scotland. ( 19211606 )
2009
35
Postcataract acute endophthalmitis in France: national prospective survey. ( 19101430 )
2009
36
Risk factors for acute endophthalmitis after cataract surgery: a population-based study. ( 19091417 )
2009
37
Acute endophthalmitis caused by Staphylococcus lugdunesis after intravitreal bevacizumab (Avastin) injection. ( 18528639 )
2009
38
Pars plana vitrectomy and silicone oil tamponade for acute endophthalmitis treatment. ( 19347118 )
2009
39
Incidence and management of acute endophthalmitis after intravitreal bevacizumab (Avastin) injection. ( 19218994 )
2009
40
Intraocular pharmacokinetics of intravenously administered marbofloxacin in rabbits with experimentally induced acute endophthalmitis. ( 18312141 )
2008
41
Visual outcome and bacterial sensitivity after methicillin-resistant Staphylococcus aureus-associated acute endophthalmitis. ( 18191097 )
2008
42
Influence of intraocular lens material on the development of acute endophthalmitis after cataract surgery? ( 16980932 )
2008
43
Adjunctive intravitreal dexamethasone in the treatment of acute endophthalmitis following cataract surgery. ( 19668397 )
2008
44
Acute endophthalmitis after 25-gauge sutureless vitrectomy. ( 17492400 )
2007
45
Acute endophthalmitis following intravitreal bevacizumab (Avastin) injection. ( 17277758 )
2007
46
Acute endophthalmitis in eyes treated prophylactically with gatifloxacin and moxifloxacin. ( 16989762 )
2006
47
Acute endophthalmitis incidence: intravitreal triamcinolone. ( 16087840 )
2005
48
Low acute endophthalmitis rate: possible explanations. ( 15975480 )
2005
49
Acute endophthalmitis following cataract surgery: a systematic review of the literature. ( 15883279 )
2005
50
Incidence of acute endophthalmitis following penetrating keratoplasty: a systematic review. ( 15883278 )
2005

Variations for Acute Endophthalmitis

Expression for Acute Endophthalmitis

Search GEO for disease gene expression data for Acute Endophthalmitis.

Pathways for Acute Endophthalmitis

Pathways related to Acute Endophthalmitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.04 C4A C4B
2 11.01 C4A C4B VEGFA
3 10.79 C4A C4B

GO Terms for Acute Endophthalmitis

Cellular components related to Acute Endophthalmitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 8.8 C4A TOR1A TOR1B

Biological processes related to Acute Endophthalmitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homooligomerization GO:0051260 9.43 PRF1 TOR1A TOR1B
2 chaperone cofactor-dependent protein refolding GO:0051085 9.32 TOR1A TOR1B
3 eye photoreceptor cell development GO:0042462 9.16 NR2E3 VEGFA
4 positive regulation of apoptotic cell clearance GO:2000427 8.96 C4A C4B
5 nuclear membrane organization GO:0071763 8.62 TOR1A TOR1B

Molecular functions related to Acute Endophthalmitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase inhibitor activity GO:0004866 8.62 C4A C4B

Sources for Acute Endophthalmitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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