MCID: ACT047
MIFTS: 29

Acute Endophthalmitis

Categories: Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Acute Endophthalmitis

MalaCards integrated aliases for Acute Endophthalmitis:

Name: Acute Endophthalmitis 12 58 15 71

Characteristics:

Orphanet epidemiological data:

58
acute endophthalmitis
Inheritance: Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:11752
ICD9CM 34 360.01
SNOMED-CT 67 1493002
ICD10 via Orphanet 33 H44.0 H44.1
UMLS via Orphanet 72 C0154773
Orphanet 58 ORPHA279888
UMLS 71 C0154773

Summaries for Acute Endophthalmitis

MalaCards based summary : Acute Endophthalmitis is related to endophthalmitis and hypopyon. An important gene associated with Acute Endophthalmitis is ASPRV1 (Aspartic Peptidase Retroviral Like 1). The drugs Betamethasone and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and colon.

Related Diseases for Acute Endophthalmitis

Diseases in the Endophthalmitis family:

Chronic Endophthalmitis Acute Endophthalmitis

Diseases related to Acute Endophthalmitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 endophthalmitis 30.6 VEGFA PRF1 ASPRV1
2 hypopyon 30.2 VEGFA ASPRV1
3 corneal edema 29.4 VEGFA FBXO7
4 cataract 10.5
5 retinal detachment 10.1
6 macular degeneration, age-related, 1 10.1
7 iridocyclitis 10.0 VEGFA ASPRV1
8 vitreoretinopathy, neovascular inflammatory 9.9
9 pars planitis 9.9
10 leukemia, acute lymphoblastic 9.9
11 kuhnt-junius degeneration 9.9
12 retinal vein occlusion 9.9
13 macular retinal edema 9.9
14 retinal disease 9.9
15 vitreoretinopathy 9.9
16 microvascular complications of diabetes 5 9.8
17 aspergillosis 9.8
18 infective endocarditis 9.8
19 osteomyelitis 9.8
20 endocarditis 9.8
21 chronic endophthalmitis 9.8
22 acute leukemia 9.8
23 uveitis 9.8
24 panophthalmitis 9.8
25 iritis 9.8
26 papilledema 9.8
27 factitious disorder 9.8
28 aortitis 9.8
29 eye disease 9.8
30 vitreous abscess 9.8
31 stenotrophomonas maltophilia infection 9.8
32 corneal disease 9.7 VEGFA FBXO7
33 patterned macular dystrophy 9.7 VEGFA NR2E3
34 blood group, globoside system 9.6 VEGFA PRF1 ASPRV1
35 macular dystrophy, dominant cystoid 9.6 VEGFA NR2E3
36 exudative vitreoretinopathy 9.4 VEGFA NR2E3
37 eye degenerative disease 9.3 VEGFA NR2E3
38 purulent endophthalmitis 8.7 VEGFA TOR1B PRF1 FBXO7 ASPRV1 AJM1

Comorbidity relations with Acute Endophthalmitis via Phenotypic Disease Network (PDN):


Hypopyon Purulent Endophthalmitis

Graphical network of the top 20 diseases related to Acute Endophthalmitis:



Diseases related to Acute Endophthalmitis

Symptoms & Phenotypes for Acute Endophthalmitis

Drugs & Therapeutics for Acute Endophthalmitis

Drugs for Acute Endophthalmitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Betamethasone Approved, Vet_approved Phase 3 378-44-9 9782
2
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
3
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
4
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
5
Polyestradiol phosphate Approved Phase 3 28014-46-2
6
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
7 Antibiotics, Antitubercular Phase 3
8 Antitubercular Agents Phase 3
9 Respiratory System Agents Phase 3
10 Hormones Phase 3
11 Anti-Asthmatic Agents Phase 3
12 Hormone Antagonists Phase 3
13 glucocorticoids Phase 3
14 Anti-Inflammatory Agents Phase 3
15 Anti-Bacterial Agents Phase 3
16 Anti-Infective Agents Phase 3
17 Estradiol 17 beta-cypionate Phase 3
18 Contraceptive Agents Phase 3
19 Estradiol 3-benzoate Phase 3
20 Contraceptives, Oral, Combined Phase 3
21 Contraceptives, Oral Phase 3
22 Norgestimate, ethinyl estradiol drug combination Phase 3
23
Ceftazidime Approved 72558-82-8, 78439-06-2 5481173
24
Vancomycin Approved 1404-90-6 14969 441141
25
Iodine Approved, Investigational 7553-56-2 807
26
Povidone-iodine Approved 25655-41-8
27
Povidone Approved 9003-39-8
28 Pharmaceutical Solutions
29 cadexomer iodine

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Interest of Intravitreal Corticotherapy as the First-line Treatment for Post-operative Endophthalmitis. Completed NCT01768078 Phase 3
2 Use of Intracameral Moxifloxacin for the Prevention of Acute Endophthalmitis Following Cataract Surgery: a Controlled and Randomized Clinical Trial Terminated NCT02770729 Phase 3 Moxifloxacin;No injection of moxifloxacin
3 Contribution of Fast Molecular Bacterial Identification by Real-time PCR in Managing of Postoperative Acute Endophthalmitis Unknown status NCT02850653
4 Evaluation do Early Pars Plana Vitrectomy in Acute Endophthalmitis Recruiting NCT04192994 Intravitreal Antibiotic Injection

Search NIH Clinical Center for Acute Endophthalmitis

Genetic Tests for Acute Endophthalmitis

Anatomical Context for Acute Endophthalmitis

MalaCards organs/tissues related to Acute Endophthalmitis:

40
Eye, Endothelial, Colon

Publications for Acute Endophthalmitis

Articles related to Acute Endophthalmitis:

(show top 50) (show all 185)
# Title Authors PMID Year
1
Toll-like receptors in acute post-cataract surgery endophthalmitis. 61
32507952 2020
2
Endophthalmitis prophylaxis study. Report 1: Intracameral cefuroxime and moxifloxacin prophylaxis for the prevention of postcataract endophthalmitis in rural India. 61
32317453 2020
3
Specific PCR and Quantitative Real-Time PCR in Ocular Samples from Acute and Delayed-Onset Postoperative Endophthalmitis. 61
31770517 2020
4
Fulminant Acanthamoeba Endophthalmitis After Cataract Surgery-A Case Report. 61
32068610 2020
5
UTILITY OF INTRAOPERATIVE OPTICAL COHERENCE TOMOGRAPHY IN ACUTE ENDOPHTHALMITIS. 61
28858193 2020
6
Post cataract Pseudomonas stutzeri endophthalmitis: Report of a case and review of literature. 61
31856535 2020
7
Surgical Management of Complications after Dexamethasone Implant. 61
32095301 2020
8
Comparative Study of Microbiological Profile and Management Outcomes of Acute Endophthalmitis after Microincision Vitrectomy Surgery versus Intravitreal Injections. 61
31900009 2020
9
Changes in Management Based on Vitreous Culture in Endophthalmitis After Intravitreal Anti-vascular Endothelial Growth Factor Injection. 61
31201794 2019
10
Pseudozyma aphidis endophthalmitis post-cataract operation: Case discussion and management. 61
31198884 2019
11
International Practice Patterns for the Management of Acute Postsurgical and Postintravitreal Injection Endophthalmitis: European Vitreo-Retinal Society Endophthalmitis Study Report 1. 61
31043364 2019
12
Incidence and Characteristics of Endophthalmitis after Cataract Surgery in Poland, during 2010-2015. 61
31226859 2019
13
Acute Bacterial Endophthalmitis Following Dexamethasone Intravitreal Implant: A Case Report. 61
31080392 2019
14
Controlled Release of Vancomycin From a Thermoresponsive Hydrogel System for the Prophylactic Treatment of Postoperative Acute Endophthalmitis. 61
31293808 2019
15
Safety and efficacy of intracameral moxifloxacin for prevention of post-cataract endophthalmitis: Randomized controlled clinical trial. 61
30691922 2019
16
The Impact of Prefilled Syringes on Endophthalmitis Following Intravitreal Injection of Ranibizumab. 61
30552891 2019
17
Physical Incompatibility between Vancomycin and Viscoelastic Mimicking Acute Endophthalmitis: The First Report. 61
30863651 2019
18
Association of Acute Endophthalmitis With Intravitreal Injections of Corticosteroids or Anti-Vascular Growth Factor Agents in a Nationwide Study in France. 61
30242325 2018
19
Utility of MALDI-TOF mass spectrometry in an outbreak investigation of acute endophthalmitis following intravitreal injection. 61
29605188 2018
20
Genetic diversity and persistent colonization of Enterococcus faecalis on ocular surfaces. 61
30324322 2018
21
Filamentous gram-negative bacteria masquerading as actinomycetes in infectious endophthalmitis: a review of three cases. 61
30306353 2018
22
Aspergillus aortitis in an immunocompetent patient presenting with acute endophthalmitis. 61
30344969 2018
23
Postoperative endophthalmitis due to Pseudomonas luteola: First reported case of acute and virulent presentation from a tertiary eye care center in South India. 61
30038182 2018
24
Vitreous hemorrhage as an early sign of acute bacterial endophthalmitis following intravitreal ranibizumab injection. 61
28365853 2018
25
Intracameral moxifloxacin after cataract surgery: a prospective study. 61
29846429 2018
26
Acute Onset of Exogenous Endophthalmitis after Dexamethasone Implant Injection Treated without Implant Removal. 61
30581640 2018
27
Pseudophakic pupillary block glaucoma in early postoperative period masquerading as endophthalmitis: Clinical features are important for differential diagnosis. 61
29563695 2018
28
Emergency management: acute endophthalmitis. 61
30487688 2018
29
Acute Endophthalmitis after Intravitreal Bevacizumab Injections at The Tertiary Centre in Nepal. 61
31056587 2018
30
Incidence of acute endophthalmitis after office based intravitreal bevacizumab injection. 61
29256542 2017
31
Acute endophthalmitis after cataract surgery: 164 consecutive cases treated at a referral center in South Korea. 61
28548647 2017
32
Acute Endophthalmitis Caused by Leuconostoc spp. following Intravitreal Bevacizumab Injection. 61
29282402 2017
33
Controlled release of moxifloxacin from intraocular lenses modified by Ar plasma-assisted grafting with AMPS or SBMA: An in vitro study. 61
28531880 2017
34
Drug-resistant coagulase-negative staphylococcal endophthalmitis following dexamethasone intravitreal implant. 61
28724830 2017
35
ACTINOMYCES NEUII ENDOPHTHALMITIS AFTER INTRAVITREAL ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR INJECTION. 61
27280342 2017
36
Randomised controlled trial of prophylactic antibiotic treatment for the prevention of endophthalmitis after open globe injury at Groote Schuur Hospital. 61
27793818 2017
37
25-GAUGE TROCAR CANNULA FOR ACUTE ENDOPHTHALMITIS-RELATED IN-OFFICE VITREOUS TAP AND INJECTION: Patient Comfort and Physician Ease of Use. 61
27471824 2017
38
Clinical presentations, risk factors and outcomes of ceftazidime-resistant Gram-negative endophthalmitis. 61
27616274 2017
39
Comparison of methods for identifying causative bacterial microorganisms in presumed acute endophthalmitis: conventional culture, blood culture, and PCR. 61
28222703 2017
40
Adjunctive steroid therapy versus antibiotics alone for acute endophthalmitis after intraocular procedure. 61
28225198 2017
41
Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery. 61
28192644 2017
42
Intravitreal dexamethasone in the management of acute endophthalmitis: a comparative retrospective study. 61
27646336 2017
43
Endophthalmitis following intravitreal injection of anti-VEGF agents: long-term outcomes and the identification of unusual micro-organisms. 61
26758203 2016
44
Endophthalmitis caused by Acinetobacter spp. as the presenting manifestation of diabetes mellitus. 61
27579461 2016
45
A Large Outbreak of Fulminant Bacterial Endophthalmitis after Intravitreal Injection of Counterfeit Bevacizumab. 61
27377655 2016
46
Current Perspectives of Prophylaxis and Management of Acute Infective Endophthalmitis. 61
26935830 2016
47
[Post-traumatic endophthalmitis]. 61
26563842 2016
48
Perioperative Antibiotics to Prevent Acute Endophthalmitis after Ophthalmic Surgery: A Systematic Review and Meta-Analysis. 61
27824933 2016
49
TWO CASES OF ACUTE ENDOPHTHALMITIS AFTER INTRAVITREAL DEXAMETHASONE IMPLANT INJECTION. 61
26426482 2016
50
Clinical analysis of 23-gauge vitrectomy for the treatment of acute endophthalmitis after cataract surgery. 61
25837637 2015

Variations for Acute Endophthalmitis

Expression for Acute Endophthalmitis

Search GEO for disease gene expression data for Acute Endophthalmitis.

Pathways for Acute Endophthalmitis

GO Terms for Acute Endophthalmitis

Biological processes related to Acute Endophthalmitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 eye photoreceptor cell development GO:0042462 8.62 VEGFA NR2E3

Sources for Acute Endophthalmitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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