MCID: ACT047
MIFTS: 29

Acute Endophthalmitis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Acute Endophthalmitis

MalaCards integrated aliases for Acute Endophthalmitis:

Name: Acute Endophthalmitis 12 59 15 73

Characteristics:

Orphanet epidemiological data:

59
acute endophthalmitis
Inheritance: Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 59  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:11752
ICD9CM 35 360.01
SNOMED-CT 68 1493002
Orphanet 59 ORPHA279888
UMLS via Orphanet 74 C0154773
ICD10 via Orphanet 34 H44.0 H44.1
UMLS 73 C0154773

Summaries for Acute Endophthalmitis

MalaCards based summary : Acute Endophthalmitis is related to endophthalmitis and cataract. An important gene associated with Acute Endophthalmitis is PRF1 (Perforin 1), and among its related pathways/superpathways is Allograft rejection. The drugs Betamethasone and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include eye, and related phenotype is vision/eye.

Related Diseases for Acute Endophthalmitis

Diseases in the Endophthalmitis family:

Chronic Endophthalmitis Acute Endophthalmitis

Diseases related to Acute Endophthalmitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 endophthalmitis 30.9 PRF1 VEGFA
2 cataract 10.4
3 blood group, globoside system 9.9 PRF1 VEGFA
4 rubeosis iridis 9.9 NDUFS4 VEGFA
5 immunoglobulin alpha deficiency 9.8 C4A TOR1A
6 tetralogy of fallot 9.8
7 endocarditis 9.8
8 factitious disorder 9.8
9 aortitis 9.8
10 kleine-levin hibernation syndrome 9.7 TOR1A TOR1B
11 purulent endophthalmitis 8.9 C4A IVD NDUFS4 PRF1 TOR1A TOR1B

Comorbidity relations with Acute Endophthalmitis via Phenotypic Disease Network (PDN):


Hypopyon Purulent Endophthalmitis

Graphical network of the top 20 diseases related to Acute Endophthalmitis:



Diseases related to Acute Endophthalmitis

Symptoms & Phenotypes for Acute Endophthalmitis

MGI Mouse Phenotypes related to Acute Endophthalmitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 8.92 IVD NDUFS4 TOR1A VEGFA

Drugs & Therapeutics for Acute Endophthalmitis

Drugs for Acute Endophthalmitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Betamethasone Approved, Vet_approved Phase 3 378-44-9 9782
2
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
3
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
4
Polyestradiol phosphate Approved Phase 3 28014-46-2
5
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
6 Estradiol valerate Approved, Investigational, Vet_approved Phase 3 979-32-8
7
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
8 Hormones Phase 3
9 Anti-Infective Agents Phase 3
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
11 Anti-Asthmatic Agents Phase 3
12 Betamethasone-17,21-dipropionate Phase 3
13 Betamethasone benzoate Phase 3
14 Antitubercular Agents Phase 3
15 Hormone Antagonists Phase 3
16 Anti-Inflammatory Agents Phase 3
17 Betamethasone Valerate Phase 3 2152-44-5
18 Anti-Bacterial Agents Phase 3
19 Respiratory System Agents Phase 3
20 glucocorticoids Phase 3
21 Betamethasone sodium phosphate Phase 3
22 Antibiotics, Antitubercular Phase 3
23 Estradiol 17 beta-cypionate Phase 3
24 Contraceptive Agents Phase 3
25 Contraceptives, Oral Phase 3
26 Topoisomerase Inhibitors Phase 3
27 Norgestimate, ethinyl estradiol drug combination Phase 3
28 Fluoroquinolones Phase 3
29 Nucleic Acid Synthesis Inhibitors Phase 3
30 Contraceptives, Oral, Combined Phase 3
31 Estradiol 3-benzoate Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Interest of Intravitreal Corticotherapy as the First-line Treatment for Post-operative Endophthalmitis Completed NCT01768078 Phase 3
2 Evaluation of Efficacy and Safety of Intracameral Moxifloxacin for Prevention of Postcataract Endophthalmitis. Terminated NCT02770729 Phase 3 Moxifloxacin;No injection of moxifloxacin
3 Targeted PCR and Acute Endophthalmitis Unknown status NCT02850653 Not Applicable

Search NIH Clinical Center for Acute Endophthalmitis

Genetic Tests for Acute Endophthalmitis

Anatomical Context for Acute Endophthalmitis

MalaCards organs/tissues related to Acute Endophthalmitis:

41
Eye

Publications for Acute Endophthalmitis

Articles related to Acute Endophthalmitis:

(show top 50) (show all 57)
# Title Authors Year
1
Utility of MALDI-TOF mass spectrometry in an outbreak investigation of acute endophthalmitis following intravitreal injection. ( 29605188 )
2018
2
Association of Acute Endophthalmitis With Intravitreal Injections of Corticosteroids or Anti-Vascular Growth Factor Agents in a Nationwide Study in France. ( 30242325 )
2018
3
Aspergillus aortitis in an immunocompetent patient presenting with acute endophthalmitis. ( 30344969 )
2018
4
Emergency management: acute endophthalmitis. ( 30487688 )
2018
5
Comparison of methods for identifying causative bacterial microorganisms in presumed acute endophthalmitis: conventional culture, blood culture, and PCR. ( 28222703 )
2017
6
Acute Endophthalmitis Caused by<i>Leuconostoc</i>spp. following Intravitreal Bevacizumab Injection. ( 29282402 )
2017
7
Acute endophthalmitis after cataract surgery: 164 consecutive cases treated at a referral center in South Korea. ( 28548647 )
2017
8
UTILITY OF INTRAOPERATIVE OPTICAL COHERENCE TOMOGRAPHY IN ACUTE ENDOPHTHALMITIS. ( 28858193 )
2017
9
Incidence of acute endophthalmitis after office based intravitreal bevacizumab injection. ( 29256542 )
2017
10
Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery. ( 28192644 )
2017
11
Adjunctive steroid therapy versus antibiotics alone for acute endophthalmitis after intraocular procedure. ( 28225198 )
2017
12
Perioperative Antibiotics to Prevent Acute Endophthalmitis after Ophthalmic Surgery: A Systematic Review and Meta-Analysis. ( 27824933 )
2016
13
25-GAUGE TROCAR CANNULA FOR ACUTE ENDOPHTHALMITIS-RELATED IN-OFFICE VITREOUS TAP AND INJECTION: Patient Comfort and Physician Ease of Use. ( 27471824 )
2016
14
Intravitreal dexamethasone in the management of acute endophthalmitis: a comparative retrospective study. ( 27646336 )
2016
15
TWO CASES OF ACUTE ENDOPHTHALMITIS AFTER INTRAVITREAL DEXAMETHASONE IMPLANT INJECTION. ( 26426482 )
2015
16
Clinical analysis of 23-gauge vitrectomy for the treatment of acute endophthalmitis after cataract surgery. ( 25837637 )
2015
17
Bilateral acute endophthalmitis associated with munchausen syndrome. ( 25799076 )
2015
18
Evidence for and against intravitreous corticosteroids in addition to intravitreous antibiotics for acute endophthalmitis. ( 24613894 )
2014
19
Incidence of acute endophthalmitis after intravitreal bevacizumab injection in a single clinical center. ( 23400076 )
2013
20
Acute endophthalmitis after intravitreal injection and preventive effect of preoperative topical antibiotics. ( 24067061 )
2013
21
Risk factors for acute endophthalmitis following cataract surgery: a systematic review and meta-analysis. ( 23990980 )
2013
22
Two rare cases of Acremonium acute endophthalmitis after cataract surgery in a tertiary care hospital. ( 24177307 )
2013
23
Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery. ( 23857416 )
2013
24
An outbreak of forty five cases of Pseudomonas aeruginosa acute endophthalmitis after phacoemulsification. ( 23471330 )
2012
25
Case control analyses of acute endophthalmitis after cataract surgery in South India associated with technique, patient care, and socioeconomic status. ( 22523647 )
2012
26
Streptococcus dysgalactiae endocarditis presenting as acute endophthalmitis. ( 24470923 )
2012
27
Acute endophthalmitis after cataract surgery at a referral centre in Northern Taiwan: review of the causative organisms, antibiotic susceptibility, and clinical features. ( 21252955 )
2011
28
Unusual acute endophthalmitis due to an as yet unclassified Acinetobacter gyllenbergii-like isolate. ( 21459914 )
2011
29
Acute endophthalmitis following 23-gauge sutureless transconjunctival vitrectomy. ( 21350291 )
2011
30
Acute endophthalmitis after cataract surgery: 250 consecutive cases treated at a tertiary referral center in the Netherlands. ( 20053391 )
2010
31
Acute endophthalmitis after cataract surgery at a referral centre in Northern Taiwan: review of the causative organisms, antibiotic susceptibility, and clinical features. ( 20379208 )
2010
32
Risk factors for acute endophthalmitis after cataract surgery: a population-based study. ( 19091417 )
2009
33
Postcataract acute endophthalmitis in France: national prospective survey. ( 19101430 )
2009
34
Incidence and visual outcome of acute endophthalmitis after cataract surgery--the experience of an eye department in Scotland. ( 19211606 )
2009
35
Acute endophthalmitis caused by Staphylococcus lugdunesis after intravitreal bevacizumab (Avastin) injection. ( 18528639 )
2009
36
Pars plana vitrectomy and silicone oil tamponade for acute endophthalmitis treatment. ( 19347118 )
2009
37
Incidence and management of acute endophthalmitis after intravitreal bevacizumab (Avastin) injection. ( 19218994 )
2009
38
Visual outcome and bacterial sensitivity after methicillin-resistant Staphylococcus aureus-associated acute endophthalmitis. ( 18191097 )
2008
39
Influence of intraocular lens material on the development of acute endophthalmitis after cataract surgery? ( 16980932 )
2008
40
Intraocular pharmacokinetics of intravenously administered marbofloxacin in rabbits with experimentally induced acute endophthalmitis. ( 18312141 )
2008
41
Adjunctive intravitreal dexamethasone in the treatment of acute endophthalmitis following cataract surgery. ( 19668397 )
2008
42
Acute endophthalmitis following intravitreal bevacizumab (Avastin) injection. ( 17277758 )
2007
43
Acute endophthalmitis after 25-gauge sutureless vitrectomy. ( 17492400 )
2007
44
Acute endophthalmitis in eyes treated prophylactically with gatifloxacin and moxifloxacin. ( 16989762 )
2006
45
Incidence of acute endophthalmitis following penetrating keratoplasty: a systematic review. ( 15883278 )
2005
46
Acute endophthalmitis incidence: intravitreal triamcinolone. ( 16087840 )
2005
47
Low acute endophthalmitis rate: possible explanations. ( 15975480 )
2005
48
Acute endophthalmitis following cataract surgery: a systematic review of the literature. ( 15883279 )
2005
49
Acute endophthalmitis following intravitreal triamcinolone acetonide injection. ( 15183833 )
2004
50
Incidence of acute endophthalmitis after triamcinolone-assisted pars plana vitrectomy. ( 15234294 )
2004

Variations for Acute Endophthalmitis

Expression for Acute Endophthalmitis

Search GEO for disease gene expression data for Acute Endophthalmitis.

Pathways for Acute Endophthalmitis

Pathways related to Acute Endophthalmitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.54 C4A PRF1 VEGFA

GO Terms for Acute Endophthalmitis

Cellular components related to Acute Endophthalmitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule GO:0030141 8.96 TOR1A VEGFA
2 endoplasmic reticulum lumen GO:0005788 8.8 C4A TOR1A TOR1B

Biological processes related to Acute Endophthalmitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chaperone cofactor-dependent protein refolding GO:0051085 9.16 TOR1A TOR1B
2 protein homooligomerization GO:0051260 9.13 PRF1 TOR1A TOR1B
3 nuclear membrane organization GO:0071763 8.62 TOR1A TOR1B

Sources for Acute Endophthalmitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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