MCID: ACT047
MIFTS: 34

Acute Endophthalmitis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Acute Endophthalmitis

MalaCards integrated aliases for Acute Endophthalmitis:

Name: Acute Endophthalmitis 12 59 15 72

Characteristics:

Orphanet epidemiological data:

59
acute endophthalmitis
Inheritance: Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 59  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:11752
ICD9CM 35 360.01
SNOMED-CT 68 1493002
ICD10 via Orphanet 34 H44.0 H44.1
UMLS via Orphanet 73 C0154773
Orphanet 59 ORPHA279888
UMLS 72 C0154773

Summaries for Acute Endophthalmitis

MalaCards based summary : Acute Endophthalmitis is related to endophthalmitis and cataract. An important gene associated with Acute Endophthalmitis is ASPRV1 (Aspartic Peptidase Retroviral Like 1), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Staphylococcus aureus infection. The drugs Betamethasone and Moxifloxacin have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and colon.

Related Diseases for Acute Endophthalmitis

Diseases in the Endophthalmitis family:

Chronic Endophthalmitis Acute Endophthalmitis

Diseases related to Acute Endophthalmitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 endophthalmitis 30.9 VEGFA PRF1
2 cataract 10.5
3 immunodeficiency due to a classical component pathway complement deficiency 10.2 C4B C4A
4 juvenile dermatitis herpetiformis 10.1 C4B C4A
5 epilepsy, familial temporal lobe, 2 10.1 C4B C4A
6 hypopyon 10.1
7 pediatric systemic lupus erythematosus 10.1 C4B C4A
8 retinal detachment 10.1
9 macular degeneration, age-related, 1 10.1
10 rubeosis iridis 10.1 VEGFA NDUFS4
11 hypersensitivity reaction type iii disease 10.0 C4B C4A
12 indeterminate leprosy 10.0 C4B C4A
13 vitreoretinopathy, neovascular inflammatory 9.9
14 pars planitis 9.9
15 leukemia, acute lymphoblastic 9.9
16 lymphocytic leukemia 9.9
17 kuhnt-junius degeneration 9.9
18 retinal vein occlusion 9.9
19 macular retinal edema 9.9
20 retinal disease 9.9
21 vitreoretinopathy 9.9
22 immunoglobulin alpha deficiency 9.9 TOR1A C4A
23 blood group, globoside system 9.8 VEGFA PRF1
24 microvascular complications of diabetes 5 9.8
25 aspergillosis 9.8
26 infective endocarditis 9.8
27 osteomyelitis 9.8
28 endocarditis 9.8
29 chronic endophthalmitis 9.8
30 corneal edema 9.8
31 acute leukemia 9.8
32 uveitis 9.8
33 panophthalmitis 9.8
34 iritis 9.8
35 papilledema 9.8
36 factitious disorder 9.8
37 aortitis 9.8
38 eye disease 9.8
39 vitreous abscess 9.8
40 48,xyyy 9.8
41 stenotrophomonas maltophilia infection 9.8
42 autoimmune disease of musculoskeletal system 9.6 C4B C4A
43 kleine-levin hibernation syndrome 9.6 TOR1B TOR1A
44 purulent endophthalmitis 8.0 VEGFA TOR1B TOR1A PRF1 NDUFS4 C4A

Comorbidity relations with Acute Endophthalmitis via Phenotypic Disease Network (PDN):


Hypopyon Purulent Endophthalmitis

Graphical network of the top 20 diseases related to Acute Endophthalmitis:



Diseases related to Acute Endophthalmitis

Symptoms & Phenotypes for Acute Endophthalmitis

Drugs & Therapeutics for Acute Endophthalmitis

Drugs for Acute Endophthalmitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Betamethasone Approved, Vet_approved Phase 3 378-44-9 9782
2
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
3
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
4
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
5
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
6
Polyestradiol phosphate Approved Phase 3 28014-46-2
7 Anti-Inflammatory Agents Phase 3
8 Respiratory System Agents Phase 3
9 glucocorticoids Phase 3
10 Hormones Phase 3
11 Antitubercular Agents Phase 3
12 Antibiotics, Antitubercular Phase 3
13 Hormone Antagonists Phase 3
14 Anti-Asthmatic Agents Phase 3
15 Betamethasone Valerate Phase 3 2152-44-5
16 Betamethasone sodium phosphate Phase 3
17 Betamethasone-17,21-dipropionate Phase 3
18 Betamethasone benzoate Phase 3
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
20 Anti-Infective Agents Phase 3
21 Anti-Bacterial Agents Phase 3
22 Contraceptives, Oral Phase 3
23 Contraceptives, Oral, Combined Phase 3
24 Norgestimate, ethinyl estradiol drug combination Phase 3
25 Contraceptive Agents Phase 3
26 Topoisomerase Inhibitors Phase 3
27 Estradiol 3-benzoate Phase 3
28 Estradiol 17 beta-cypionate Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Interest of Intravitreal Corticotherapy as the First-line Treatment for Post-operative Endophthalmitis. Completed NCT01768078 Phase 3
2 Use of Intracameral Moxifloxacin for the Prevention of Acute Endophthalmitis Following Cataract Surgery: a Controlled and Randomized Clinical Trial Terminated NCT02770729 Phase 3 Moxifloxacin;No injection of moxifloxacin
3 Contribution of Fast Molecular Bacterial Identification by Real-time PCR in Managing of Postoperative Acute Endophthalmitis Unknown status NCT02850653

Search NIH Clinical Center for Acute Endophthalmitis

Genetic Tests for Acute Endophthalmitis

Anatomical Context for Acute Endophthalmitis

MalaCards organs/tissues related to Acute Endophthalmitis:

41
Eye, Endothelial, Colon

Publications for Acute Endophthalmitis

Articles related to Acute Endophthalmitis:

(show top 50) (show all 178)
# Title Authors PMID Year
1
Pseudozyma aphidis endophthalmitis post-cataract operation: Case discussion and management. 38
31198884 2019
2
Changes in management based on vitreous culture in endophthalmitis after intravitreal anti-vascular endothelial growth factor injection. 38
31201794 2019
3
Incidence and Characteristics of Endophthalmitis after Cataract Surgery in Poland, during 2010-2015. 38
31226859 2019
4
International Practice Patterns for the Management of Acute Postsurgical and Postintravitreal Injection Endophthalmitis: European Vitreo-Retinal Society Endophthalmitis Study Report 1. 38
31043364 2019
5
Acute Bacterial Endophthalmitis Following Dexamethasone Intravitreal Implant: A Case Report. 38
31080392 2019
6
Controlled Release of Vancomycin From a Thermoresponsive Hydrogel System for the Prophylactic Treatment of Postoperative Acute Endophthalmitis. 38
31293808 2019
7
Safety and efficacy of intracameral moxifloxacin for prevention of post-cataract endophthalmitis: Randomized controlled clinical trial. 38
30691922 2019
8
The Impact of Prefilled Syringes on Endophthalmitis Following Intravitreal Injection of Ranibizumab. 38
30552891 2019
9
Physical Incompatibility between Vancomycin and Viscoelastic Mimicking Acute Endophthalmitis: The First Report. 38
30863651 2019
10
Association of Acute Endophthalmitis With Intravitreal Injections of Corticosteroids or Anti-Vascular Growth Factor Agents in a Nationwide Study in France. 38
30242325 2018
11
Utility of MALDI-TOF mass spectrometry in an outbreak investigation of acute endophthalmitis following intravitreal injection. 38
29605188 2018
12
Genetic diversity and persistent colonization of Enterococcus faecalis on ocular surfaces. 38
30324322 2018
13
Filamentous gram-negative bacteria masquerading as actinomycetes in infectious endophthalmitis: a review of three cases. 38
30306353 2018
14
Aspergillus aortitis in an immunocompetent patient presenting with acute endophthalmitis. 38
30344969 2018
15
Postoperative endophthalmitis due to Pseudomonas luteola: First reported case of acute and virulent presentation from a tertiary eye care center in South India. 38
30038182 2018
16
Vitreous hemorrhage as an early sign of acute bacterial endophthalmitis following intravitreal ranibizumab injection. 38
28365853 2018
17
Intracameral moxifloxacin after cataract surgery: a prospective study. 38
29846429 2018
18
Acute Onset of Exogenous Endophthalmitis after Dexamethasone Implant Injection Treated without Implant Removal. 38
30581640 2018
19
Pseudophakic pupillary block glaucoma in early postoperative period masquerading as endophthalmitis: Clinical features are important for differential diagnosis. 38
29563695 2018
20
Emergency management: acute endophthalmitis. 38
30487688 2018
21
Acute Endophthalmitis after Intravitreal Bevacizumab Injections at The Tertiary Centre in Nepal. 38
31056587 2018
22
Incidence of acute endophthalmitis after office based intravitreal bevacizumab injection. 38
29256542 2017
23
Acute endophthalmitis after cataract surgery: 164 consecutive cases treated at a referral center in South Korea. 38
28548647 2017
24
Acute Endophthalmitis Caused by Leuconostoc spp. following Intravitreal Bevacizumab Injection. 38
29282402 2017
25
UTILITY OF INTRAOPERATIVE OPTICAL COHERENCE TOMOGRAPHY IN ACUTE ENDOPHTHALMITIS. 38
28858193 2017
26
Controlled release of moxifloxacin from intraocular lenses modified by Ar plasma-assisted grafting with AMPS or SBMA: An in vitro study. 38
28531880 2017
27
Drug-resistant coagulase-negative staphylococcal endophthalmitis following dexamethasone intravitreal implant. 38
28724830 2017
28
ACTINOMYCES NEUII ENDOPHTHALMITIS AFTER INTRAVITREAL ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR INJECTION. 38
27280342 2017
29
Randomised controlled trial of prophylactic antibiotic treatment for the prevention of endophthalmitis after open globe injury at Groote Schuur Hospital. 38
27793818 2017
30
25-GAUGE TROCAR CANNULA FOR ACUTE ENDOPHTHALMITIS-RELATED IN-OFFICE VITREOUS TAP AND INJECTION: Patient Comfort and Physician Ease of Use. 38
27471824 2017
31
Clinical presentations, risk factors and outcomes of ceftazidime-resistant Gram-negative endophthalmitis. 38
27616274 2017
32
Comparison of methods for identifying causative bacterial microorganisms in presumed acute endophthalmitis: conventional culture, blood culture, and PCR. 38
28222703 2017
33
Adjunctive steroid therapy versus antibiotics alone for acute endophthalmitis after intraocular procedure. 38
28225198 2017
34
Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery. 38
28192644 2017
35
Intravitreal dexamethasone in the management of acute endophthalmitis: a comparative retrospective study. 38
27646336 2017
36
Endophthalmitis following intravitreal injection of anti-VEGF agents: long-term outcomes and the identification of unusual micro-organisms. 38
26758203 2016
37
Endophthalmitis caused by Acinetobacter spp. as the presenting manifestation of diabetes mellitus. 38
27579461 2016
38
A Large Outbreak of Fulminant Bacterial Endophthalmitis after Intravitreal Injection of Counterfeit Bevacizumab. 38
27377655 2016
39
Current Perspectives of Prophylaxis and Management of Acute Infective Endophthalmitis. 38
26935830 2016
40
[Post-traumatic endophthalmitis]. 38
26563842 2016
41
Perioperative Antibiotics to Prevent Acute Endophthalmitis after Ophthalmic Surgery: A Systematic Review and Meta-Analysis. 38
27824933 2016
42
TWO CASES OF ACUTE ENDOPHTHALMITIS AFTER INTRAVITREAL DEXAMETHASONE IMPLANT INJECTION. 38
26426482 2016
43
Clinical analysis of 23-gauge vitrectomy for the treatment of acute endophthalmitis after cataract surgery. 38
25837637 2015
44
Endophthalmitis After Intravitreal Injections: Incidence, Presentation, Management, and Visual Outcome. 38
25892127 2015
45
Endogenous endophthalmitis secondary to erysipelas. 38
26123459 2015
46
Incidence of post-intravitreal anti-VEGF endophthalmitis at Thammasat University Hospital. 38
26058278 2015
47
Reevaluating intracameral cefuroxime as a prophylaxis against endophthalmitis after cataract surgery in India. 38
25535109 2015
48
Endophthalmitis after resident-performed intravitreal bevacizumab injection. 38
25677280 2015
49
Risk factors for endophthalmitis following cataract surgery-our experience at a tertiary eye care centre in India. 38
26682170 2015
50
Bilateral acute endophthalmitis associated with munchausen syndrome. 38
25799076 2015

Variations for Acute Endophthalmitis

Expression for Acute Endophthalmitis

Search GEO for disease gene expression data for Acute Endophthalmitis.

Pathways for Acute Endophthalmitis

Pathways related to Acute Endophthalmitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.01 VEGFA C4B C4A
2 10.94 C4B C4A

GO Terms for Acute Endophthalmitis

Cellular components related to Acute Endophthalmitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 8.8 TOR1B TOR1A C4A

Biological processes related to Acute Endophthalmitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homooligomerization GO:0051260 9.5 TOR1B TOR1A PRF1
2 chaperone cofactor-dependent protein refolding GO:0051085 9.26 TOR1B TOR1A
3 eye photoreceptor cell development GO:0042462 9.16 VEGFA NR2E3
4 positive regulation of apoptotic cell clearance GO:2000427 8.96 C4B C4A
5 nuclear membrane organization GO:0071763 8.62 TOR1B TOR1A

Molecular functions related to Acute Endophthalmitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase inhibitor activity GO:0004866 8.62 C4B C4A

Sources for Acute Endophthalmitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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