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AGEP
MCID: ACT167
MIFTS: 38

Acute Generalized Exanthematous Pustulosis (AGEP)

Categories: Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Acute Generalized Exanthematous Pustulosis

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MalaCards integrated aliases for Acute Generalized Exanthematous Pustulosis:

Name: Acute Generalized Exanthematous Pustulosis 58 70
Agep 58 70
Pustular Drug Eruption 58
Toxic Pustuloderma 58

Characteristics:

Orphanet epidemiological data:

58
acute generalized exanthematous pustulosis
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
Orphanet: 58  
Rare skin diseases


External Ids:

UMLS via Orphanet 71 C0853331 C0877055
Orphanet 58 ORPHA293173
UMLS 70 C0863129 C0877055
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Summaries for Acute Generalized Exanthematous Pustulosis

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MalaCards based summary : Acute Generalized Exanthematous Pustulosis, also known as agep, is related to psoriasis 14, pustular and pustulosis of palm and sole. An important gene associated with Acute Generalized Exanthematous Pustulosis is IL36RN (Interleukin 36 Receptor Antagonist), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Affiliated tissues include skin, neutrophil and t cells, and related phenotypes are digestive/alimentary and hematopoietic system

Wikipedia : 73 Acute generalized exanthematous pustulosis (AGEP) (also known as pustular drug eruption and toxic... more...

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Related Diseases for Acute Generalized Exanthematous Pustulosis

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Diseases related to Acute Generalized Exanthematous Pustulosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 210)
# Related Disease Score Top Affiliating Genes
1 psoriasis 14, pustular 31.5 IL36RN IL17A
2 pustulosis of palm and sole 31.4 IL36RN IL17A CXCL8
3 erythema multiforme 31.0 PTGS2 CXCL8
4 pityriasis rubra pilaris 30.6 IL36RN IL17A
5 viral pneumonia 30.6 IL17A CXCL8
6 ulcerative colitis 30.4 IL22 IL17A CXCL8
7 common cold 30.4 IL17A CXCL8
8 bacterial infectious disease 30.3 MX1 IL17A CXCL8
9 contact dermatitis 30.3 IL22 IL17F IL17A CXCL8
10 pneumonia 30.3 IL22 IL17A CXCL8
11 psoriasis 30.2 IL36RN IL36G IL22 IL17F IL17A CXCL8
12 keratoconjunctivitis 30.2 IL17A CXCL8
13 pharyngitis 30.2 PTGS2 CXCL8
14 allergic contact dermatitis 30.2 IL22 IL17F IL17A CXCL8
15 autoimmune disease 30.2 IL22 IL17F IL17A CXCL8
16 periodontitis 29.9 PTGS2 IL17A CXCL8
17 colitis 29.8 PTGS2 IL22 IL17A CXCL8
18 skin disease 29.7 MX1 IL36RN IL22 IL17A CXCL8
19 exanthem 11.1
20 pustular psoriasis 11.0
21 stevens-johnson syndrome/toxic epidermal necrolysis 10.9
22 severe cutaneous adverse reaction 10.9
23 hypereosinophilic syndrome 10.7
24 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 10.7
25 vasculitis 10.6
26 erythema multiforme major 10.6
27 drug allergy 10.6
28 allergic disease 10.6
29 covid-19 10.5
30 urinary tract infection 10.5
31 toxic shock syndrome 10.5
32 dermatitis 10.5
33 drug reaction with eosinophilia and systemic symptoms 10.5
34 urticaria 10.4
35 cytokine deficiency 10.4
36 leukemia, chronic myeloid 10.3
37 optic neuritis 10.3
38 acute cystitis 10.3
39 neuritis 10.3
40 severe acute respiratory syndrome 10.3
41 purpura 10.3
42 syphilis 10.3
43 spongiotic dermatitis 10.3
44 subcorneal pustular dermatosis 10.3
45 myeloid leukemia 10.3
46 pemphigus 10.3
47 neutrophilic dermatosis, acute febrile 10.2 IL36RN CXCL8
48 neurosyphilis 10.2 IL17A CXCL8
49 inflammatory diarrhea 10.2 IL17A CXCL8
50 mycetoma 10.2 IL17A CXCL8

Graphical network of the top 20 diseases related to Acute Generalized Exanthematous Pustulosis:



Diseases related to Acute Generalized Exanthematous Pustulosis
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Symptoms & Phenotypes for Acute Generalized Exanthematous Pustulosis

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MGI Mouse Phenotypes related to Acute Generalized Exanthematous Pustulosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.73 IL17A IL17F IL22 IL36G PTGS2 WRN
2 hematopoietic system MP:0005397 9.7 IL17A IL17F IL22 IL36G IL36RN PTGS2
3 immune system MP:0005387 9.5 IL17A IL17F IL22 IL36G IL36RN PTGS2
4 respiratory system MP:0005388 9.02 IL17A IL17F IL22 IL36G PTGS2
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Drugs & Therapeutics for Acute Generalized Exanthematous Pustulosis

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Multicenter Registry of Patients With Severe Cutaneous Adverse Reactions Among Tertiary Medical Institutes in Thailand Unknown status NCT02574988
2 Assessment of the Enrichment of Rare Coding Genetic Variants in Patients Affected by Neutrophil-Mediated Inflammatory Dermatoses Unknown status NCT01952275

Search NIH Clinical Center for Acute Generalized Exanthematous Pustulosis

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Genetic Tests for Acute Generalized Exanthematous Pustulosis

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Anatomical Context for Acute Generalized Exanthematous Pustulosis

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MalaCards organs/tissues related to Acute Generalized Exanthematous Pustulosis:

40
Skin, Neutrophil, T Cells, Kidney, Myeloid, Smooth Muscle, Endothelial
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Publications for Acute Generalized Exanthematous Pustulosis

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Articles related to Acute Generalized Exanthematous Pustulosis:

(show top 50) (show all 766)
# Title Authors PMID Year
1
Acute generalized exanthematous pustulosis triggered by acetaminophen in an IL36RN variant heterozygote. 61
33560533 2021
2
Acute generalized exanthematous pustulosis induced by enoxaparin: 2 cases. 61
33131094 2021
3
Acute generalized exanthematous pustulosis associated with human parvovirus B19 infection in an adolescent. 61
33735493 2021
4
Granular C3 dermatosis-like immunological manifestation found in a case of acute generalized exanthematous pustulosis: Implication for the mechanism in C3 deposition to the epidermal basement membrane zone. 61
33745201 2021
5
Acute Generalized Exanthematous Pustulosis. 61
33688926 2021
6
DRESS and AGEP reactions to iodinated contrast media: a French case series. 61
33757916 2021
7
Acute generalized exanthematous pustulosis associated with coccidiomycosis infection. 61
33614876 2021
8
Evaluation of drug patch tests in children. 61
33685563 2021
9
Systematic review of BRAF/MEK inhibitors-induced Severe Cutaneous Adverse Reactions (SCARs). 61
32846030 2021
10
Potentially life‑threatening severe cutaneous adverse reactions associated with tyrosine kinase inhibitors (Review). 61
33650659 2021
11
Severe cutaneous adverse drug reactions: diagnostic approach and genetic study in a Brazilian case series. 61
33728835 2021
12
Hydroxychloroquine-induced acute generalized exanthematous pustulosis: an adverse reaction to keep in mind during COVID-19 pandemic. 61
33617141 2021
13
Dendritic cells inclusion and cell-subset assessment improve flow-cytometry-based proliferation test in non-immediate drug hypersensitivity reactions. 61
33523478 2021
14
Hydroxychloroquine-induced acute generalized exanthematous pustulosis: a series of seven patients and review of the literature. 61
33598928 2021
15
Acute generalized exanthematous pustulosis induced by pseudoephedrine in a combination tablet with fexofenadine. 61
33559159 2021
16
Terbinafine-induced acute generalized exanthematous pustulosis. 61
33528556 2021
17
Acute Generalized Exanthematous Pustulosis with Multiple Organ Failure. 61
33708082 2021
18
A systematic review on treatment-related mucocutaneous reactions in COVID-19 patients. 61
33301232 2021
19
Skin and Mucous Membrane Eruptions Associated with Chlamydophila Pneumoniae Respiratory Infections: Literature Review. 61
32222707 2021
20
Dermoscopic Aspects of Cutaneous Adverse Drug Reactions. 61
33614215 2021
21
The Role of Frozen Section in the Rapid Diagnosis of Severe Cutaneous Adverse Drug Reactions. 61
33768026 2021
22
Cutaneous eruption in COVID-19-infected patients in Thailand: An observational descriptive study. 61
33180327 2021
23
The Role of In Vivo and Ex Vivo Diagnostic Tools in Severe Delayed Immune-Mediated Adverse Antibiotic Drug Reactions. 61
33453452 2021
24
A retrospective, 5-year, clinicoepidemiological study of severe cutaneous adverse reactions (SCARs). 61
33454956 2021
25
Fluconazole-induced acute generalized exanthematous pustulosis. 61
32641264 2021
26
Acute Generalized Exanthematous Pustulosis (AGEP) in 12 Patients Treated for SARS-CoV-2 Positive Pneumonia. 61
33405402 2021
27
Acute generalized exanthematous pustulosis in children and adolescents in Singapore: A ten-year retrospective review. 61
33336363 2020
28
Severe acute generalized exanthematous pustulosis (AGEP) induced by miconazole oral gel with overlapping features of drug reaction with eosinophilia and systemic symptoms (DRESS). 61
33382118 2020
29
DRESS syndrome following furosemide administration: An unusual association. 61
33203615 2020
30
Triad of acute generalized exanthematous pustulosis, delirium, and lactic acidosis due to azithromycin. 61
33294557 2020
31
Acute generalized exanthematous pustulosis with a focus on hydroxychloroquine: A 10-year experience in a skin hospital. 61
33091817 2020
32
Acute generalized exanthematous pustulosis due to dextromethorphan. 61
32506524 2020
33
A Case of Vancomycin-induced Acute Generalized Exanthematous Pustulosis Confirmed by Patch Testing. 61
33282101 2020
34
Prolonged acute generalized exanthematous pustulosis and atypical target-like lesions induced by hydroxychloroquine. 61
32770860 2020
35
The necessity of patch testing in determining the causative drug of AGEP. 61
33190407 2020
36
Acute generalized exanthematous pustulosis and Stevens-Johnson syndrome overlap due to hydroxychloroquine: a case report. 61
33138853 2020
37
Widespread pustular eruption following probiotic use. 61
33342179 2020
38
Acute Generalized Exanthematous Pustulosis After COVID-19 Infection: A Case Report From Saudi Arabia. 61
33240733 2020
39
Acute generalized exanthematous pustulosis induced by empiric hydroxychloroquine for presumed COVID-19. 61
32542893 2020
40
Late-onset AGEP-like skin pustular eruption following COVID-19: A possible association. 61
32885892 2020
41
Acute generalised exanthematous pustulosis associated with shock. 61
33127730 2020
42
Delayed Presentation of Acute Generalized Exanthematous Pustulosis Following Treatment with Cefepime in a Patient with COVID-19 without the Use of Hydroxychloroquine. 61
33097683 2020
43
Development and Validation of a Questionnaire on Knowledge, Attitude, and Perception Towards Allergic Reactions of Paracetamol. 61
33679089 2020
44
Tosufloxacin-induced acute generalized exanthematous pustulosis confirmed by a drug-induced lymphocyte stimulation test. 61
32995434 2020
45
Acute generalized exanthematous pustulosis. 61
33077522 2020
46
A case of cefditoren-induced acute generalized exanthematous pustulosis during COVID-19 pandemics. Severe cutaneous adverse reactions are an issue. 61
32455478 2020
47
Acute Generalized Exanthematous Pustulosis Secondary to Oral Nystatin. 61
33012345 2020
48
Acute generalized exanthematous pustulosis caused by iopamidol with recurrence on rechallenge with iopromide. 61
32995418 2020
49
Curcumin-induced acute generalized exanthematous pustulosis. 61
32769304 2020
50
Acute generalized exanthematous pustulosis caused by an intravenous radiocontrast medium. 61
32958574 2020
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Variations for Acute Generalized Exanthematous Pustulosis

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Expression for Acute Generalized Exanthematous Pustulosis

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Search GEO for disease gene expression data for Acute Generalized Exanthematous Pustulosis.
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Pathways for Acute Generalized Exanthematous Pustulosis

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Pathways related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.61 PTGS2 MX1 IL36G IL22 IL17F IL17A
2
PEDF Induced Signaling 63
Show member pathways
 13.21 PTGS2 IL36RN IL36G IL22 IL17F IL17A
3
Cytokine Signaling in Immune system 65
Show member pathways
 12.28 PTGS2 MX1 IL36G IL22 IL17F IL17A
4
IL-17 Family Signaling Pathways 64
Show member pathways
 11.89 PTGS2 IL17F IL17A CXCL8
5
IL-1 Family Signaling Pathways 64
Show member pathways
 11.7 PTGS2 IL36RN IL36G CXCL8
6
Cytokine production by Th17 cells in CF (Mouse model) 23
Show member pathways
 11.55 IL17F IL17A CXCL8
7
Th17 Differentiation Pathway 64
Show member pathways
 11.5 IL22 IL17F IL17A
8
Interleukin-4 and 13 signaling 65
11.31 PTGS2 IL17F IL17A CXCL8
9
Hepatitis C and Hepatocellular Carcinoma 1
11.23 PTGS2 CXCL8
10
Interleukin-10 signaling 65
11.2 PTGS2 CXCL8
11
Development and heterogeneity of the ILC family 1
11 IL22 IL17A
12
IL1 Signaling Pathway 66
10.89 IL36RN IL36G
13
Overview of nanoparticle effects 1
10.71 PTGS2 CXCL8
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GO Terms for Acute Generalized Exanthematous Pustulosis

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Cellular components related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 IL36RN IL36G IL22 IL17F IL17A CXCL8
2 extracellular space GO:0005615 9.1 IL36RN IL36G IL22 IL17F IL17A CXCL8

Biological processes related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.77 MX1 IL36RN IL36G IL17F IL17A
2 immune response GO:0006955 9.73 IL36RN IL36G IL17A CXCL8
3 innate immune response GO:0045087 9.65 MX1 IL36RN IL36G IL17F IL17A
4 cellular response to lipopolysaccharide GO:0071222 9.63 IL36RN IL36G CXCL8
5 receptor internalization GO:0031623 9.51 MX1 CXCL8
6 inflammatory response GO:0006954 9.5 PTGS2 IL36RN IL36G IL22 IL17F IL17A
7 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.49 IL17F IL17A
8 inflammatory response to antigenic stimulus GO:0002437 9.48 IL36RN IL36G
9 interleukin-17-mediated signaling pathway GO:0097400 9.4 IL17F IL17A
10 positive regulation of chemokine (C-X-C motif) ligand 1 production GO:2000340 9.32 IL17F IL17A
11 cytokine-mediated signaling pathway GO:0019221 9.17 PTGS2 IL36RN IL36G IL22 IL17F IL17A
12 positive regulation of antimicrobial peptide production GO:0002225 9.16 IL17F IL17A

Molecular functions related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.46 WRN PTGS2 IL17F IL17A
2 cytokine activity GO:0005125 9.1 IL36RN IL36G IL22 IL17F IL17A CXCL8
3 interleukin-1 receptor binding GO:0005149 8.96 IL36RN IL36G
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Sources for Acute Generalized Exanthematous Pustulosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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