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AGEP
MCID: ACT167
MIFTS: 37

Acute Generalized Exanthematous Pustulosis (AGEP)

Categories: Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Acute Generalized Exanthematous Pustulosis

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MalaCards integrated aliases for Acute Generalized Exanthematous Pustulosis:

Name: Acute Generalized Exanthematous Pustulosis 58 71
Agep 58 71
Pustular Drug Eruption 58
Toxic Pustuloderma 58

Characteristics:

Orphanet epidemiological data:

58
acute generalized exanthematous pustulosis
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
Orphanet: 58  
Rare skin diseases


External Ids:

UMLS via Orphanet 72 C0853331 C0877055
Orphanet 58 ORPHA293173
UMLS 71 C0863129 C0877055
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Summaries for Acute Generalized Exanthematous Pustulosis

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MalaCards based summary : Acute Generalized Exanthematous Pustulosis, also known as agep, is related to pustulosis of palm and sole and erythema multiforme. An important gene associated with Acute Generalized Exanthematous Pustulosis is IL36RN (Interleukin 36 Receptor Antagonist), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Petrolatum and Eslicarbazepine acetate have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and neutrophil, and related phenotype is digestive/alimentary.

Wikipedia : 74 Acute generalized exanthematous pustulosis (AGEP) (also known as pustular drug eruption and toxic... more...

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Related Diseases for Acute Generalized Exanthematous Pustulosis

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Diseases related to Acute Generalized Exanthematous Pustulosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 194)
# Related Disease Score Top Affiliating Genes
1 pustulosis of palm and sole 31.5 IL36RN IL17A CXCL8
2 erythema multiforme 30.8 PTGS2 CXCL8
3 pityriasis rubra pilaris 30.6 IL36RN IL17A
4 allergic contact dermatitis 30.4 IL17F IL17A CXCL8
5 ulcerative colitis 30.3 IL22 IL17A CXCL8
6 bacterial infectious disease 30.1 MX1 IL17A CXCL8
7 pharyngitis 30.0 PTGS2 CXCL8
8 psoriasis 29.9 IL36RN IL36G IL22 IL17F IL17A CXCL8
9 common cold 29.8 IL17A CXCL8
10 periodontitis 29.7 PTGS2 IL17A CXCL8
11 autoimmune disease 29.7 IL22 IL17F IL17A CXCL8
12 skin disease 29.6 MX1 IL36RN IL22 IL17A CXCL8
13 colitis 29.5 PTGS2 IL22 IL17A CXCL8
14 rheumatoid arthritis 28.8 PTGS2 IL22 IL17A CXCL8
15 exanthem 11.0
16 pustular psoriasis 10.9
17 stevens-johnson syndrome/toxic epidermal necrolysis 10.9
18 severe cutaneous adverse reaction 10.7
19 allergic hypersensitivity disease 10.7
20 psoriasis 14, pustular 10.7
21 hypereosinophilic syndrome 10.7
22 vasculitis 10.6
23 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 10.6
24 drug allergy 10.6
25 erythema multiforme major 10.6
26 covid-19 10.5
27 dermatitis 10.4
28 contact dermatitis 10.4
29 myeloid leukemia 10.4
30 cytokine deficiency 10.4
31 myeloma, multiple 10.3
32 leukemia, chronic myeloid 10.3
33 optic neuritis 10.3
34 acute cystitis 10.3
35 toxic shock syndrome 10.3
36 urticaria 10.3
37 neuritis 10.3
38 purpura 10.3
39 syphilis 10.3
40 spongiotic dermatitis 10.3
41 subcorneal pustular dermatosis 10.3
42 pemphigus 10.3
43 47,xyy 10.3
44 drug reaction with eosinophilia and systemic symptoms 10.3
45 neurosyphilis 10.3 IL17A CXCL8
46 transverse myelitis 10.3 IL17A CXCL8
47 myelitis 10.3 IL17A CXCL8
48 inflammatory diarrhea 10.3 IL17A CXCL8
49 mycetoma 10.3 IL17A CXCL8
50 periapical periodontitis 10.3 IL17A CXCL8

Graphical network of the top 20 diseases related to Acute Generalized Exanthematous Pustulosis:



Diseases related to Acute Generalized Exanthematous Pustulosis
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Symptoms & Phenotypes for Acute Generalized Exanthematous Pustulosis

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MGI Mouse Phenotypes related to Acute Generalized Exanthematous Pustulosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.02 IL17A IL17F IL22 PTGS2 WRN
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Drugs & Therapeutics for Acute Generalized Exanthematous Pustulosis

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Drugs for Acute Generalized Exanthematous Pustulosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Petrolatum Approved, Investigational 8009-03-8
2
Eslicarbazepine acetate Approved 75970-99-9, 236395-14-5 123618
3 Immunoglobulin A

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Drug Patch Tests, Enzyme-linked Immunosorbent Spot Assay (Elispot) and Lymphocyte Transformation Tests in Patients With Severe Cutaneous Adverse Reaction to Drugs (SCARs) Unknown status NCT03176342
2 Assessment of the Enrichment of Rare Coding Genetic Variants in Patients Affected by Neutrophil-Mediated Inflammatory Dermatoses Unknown status NCT01952275
3 The Multicenter Registry of Patients With Severe Cutaneous Adverse Reactions Among Tertiary Medical Institutes in Thailand Recruiting NCT02574988
4 An Exploratory Case-Control Study of Genetic and Clinical Factors for Serious Cutaneous Reactions Among Users of Eslicarbazepine Acetate Recruiting NCT02520557
5 Adverse Cutaneous Drug Reactions Collection of Clinical Data and Biological Samples Recruiting NCT03659227

Search NIH Clinical Center for Acute Generalized Exanthematous Pustulosis

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Genetic Tests for Acute Generalized Exanthematous Pustulosis

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Anatomical Context for Acute Generalized Exanthematous Pustulosis

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MalaCards organs/tissues related to Acute Generalized Exanthematous Pustulosis:

40
Testes, Skin, Neutrophil, T Cells, Smooth Muscle, Myeloid, Lung
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Publications for Acute Generalized Exanthematous Pustulosis

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Articles related to Acute Generalized Exanthematous Pustulosis:

(show top 50) (show all 711)
# Title Authors PMID Year
1
Clinical and histopathologic features differentiating acute generalized exanthematous pustulosis and pustular psoriasis: A retrospective series. 61
32173359 2020
2
Cyclosporine for treatment of acute generalized exanthematous pustulosis: A retrospective analysis. 61
32151625 2020
3
Interleukin 17 as a therapeutic target of acute generalized exanthematous pustulosis (AGEP). 61
32014613 2020
4
Acute generalized exanthematous pustulosis due to dextromethorphan. 61
32506524 2020
5
[DRESS syndrome with pustules and cardiac impairment]. 61
32164921 2020
6
Acute generalized exanthematous pustulosis induced by hydroxychloroquine prescribed for COVID-19. 61
32525093 2020
7
Acute generalized exanthematous pustulosis induced by empiric hydroxychloroquine for presumed COVID-19. 61
32542893 2020
8
A case of cefditoren-induced Acute Generalized Exanthematous Pustulosis during COVID-19 pandemics. Severe Cutaneous Adverse Reactions (SCARs) are an issue. 61
32455478 2020
9
Acute generalized exanthematous pustulosis after COVID-19 treatment with hydroxychloroquine. 61
32401410 2020
10
Acute Generalized Exanthematous Pustulosis with Erythema Multiforme-Like lesions in a COVID-19 woman. 61
32386448 2020
11
Clindamycin-induced acute generalized exanthematous pustulosis: A case report. 61
32481338 2020
12
Acute generalized exanthematous pustulosis with features mimicking toxic epidermal necrolysis secondary to amiodarone. 61
32522449 2020
13
HLA-B*58: 01 association in allopurinol-induced severe cutaneous adverse reactions: the implication of ethnicity and clinical phenotypes in multiethnic Malaysia. 61
32433341 2020
14
Acute generalized exanthematous pustulosis caused by propafenone: An emerging skin adverse reaction. 61
32413180 2020
15
Acute Generalized Exanthematous Pustulosis Induced by Topical Morphine and Confirmed by Patch Testing. 61
32404627 2020
16
Acute generalized exanthematous pustulosis induced by iron carboxymaltose infusion: A case report. 61
32323452 2020
17
Generalized pustular figurate erythema: A newly delineated severe cutaneous drug reaction linked with hydroxychloroquine. 61
32253799 2020
18
Cetirizine induced acute generalized exanthematous pustulosis confirmed by patch testing. 61
31782151 2020
19
Systemic allergic dermatitis presenting as acute generalized exanthematous pustulosis due to betamethasone sodium phosphate. 61
31821599 2020
20
Coexisting mutations in CARD14 and NUDT15 detected in a young female with azathioprine hypersensitivity syndrome manifested as acute generalized exanthematous pustulosis. 61
31994212 2020
21
Characterizing the adverse dermatologic effects of hydroxychloroquine: A systematic review. 61
32289395 2020
22
Hypersensitivity reactions to proton-pump inhibitors: Clinical presentation, diagnosis, and management. 61
32122452 2020
23
Acute Generalized Exanthematous Pustulosis Caused by the Combination of Pembrolizumab Plus Chemotherapy in a Patient With Squamous-Cell Carcinoma. 61
31874730 2020
24
Skin and Mucous Membrane Eruptions Associated with Chlamydophila Pneumoniae Respiratory Infections: Literature Review. 61
32222707 2020
25
Acute generalized exanthematous pustulosis induced by Mycophenolate Mofetil: A case complicated with pemphigus foliaceus. 61
31996549 2020
26
Acute Generalized Exanthematous Pustulosis Due to Clavulanic Acid. 61
31631017 2020
27
First case report of acute generalized exanthematous pustulosis (AGEP) caused by mifepristone. 61
31626328 2020
28
A case of acute generalized exanthematous pustulosis caused by exposure to Atovaquone/proguanil. 61
32163144 2020
29
[Acute localized exanthematous pustulosis following heparin calcium injections]. 61
32029300 2020
30
The impact of the Adolescent Girls Empowerment Program (AGEP) on short and long term social, economic, education and fertility outcomes: a cluster randomized controlled trial in Zambia. 61
32183783 2020
31
Severe cutaneous adverse reactions (SCARs) to drugs in Latin America: RACGRAD study. 61
32101172 2020
32
Acute generalized exanthematous pustulosis induced by hydroxychloroquine successfully treated with etretinate. 61
31840277 2020
33
Linagliptin-induced acute generalized exanthematous pustulosis (AGEP). 61
32057219 2020
34
Acute Generalized Exanthematous Pustulosis Due to Teicoplanin. 61
32101176 2020
35
Beta-lactam allergy in the paediatric population. 61
32042244 2020
36
Aetiopathogenesis of severe cutaneous adverse reactions (SCARs) in children: A 9-year experience in a tertiary care paediatric hospital setting. 61
31608511 2020
37
The life-threatening eruptions of immune checkpoint inhibitor therapy. 61
32197753 2020
38
Dermatoscopy in life-threatening and severe acute rashes. 61
32197741 2020
39
Coupled Plasma Filtration Adsorption for Treatment of Capillary Leak Syndrome Superimposed to Acute Generalized Exanthematous Pustolosis: A Case Report. 61
32069462 2020
40
Acute generalized exanthematous pustulosis simulating toxic epidermal necrolysis: case presentation and literature review. 61
32042284 2020
41
Accidental re-exposure causing repeated severe acute generalized exanthematous pustulosis. 61
30817022 2019
42
Contrast media and cutaneous reactions. Part 2: Delayed hypersensitivity reactions to iodinated contrast media. 61
31162717 2019
43
Drug-induced severe cutaneous adverse reactions: Determine the cause and prevention. 61
31400461 2019
44
Acute generalized exanthematous pustulosis induced by amoxicillin/clavulanic acid, manifesting as severe laryngeal edema. 61
31321789 2019
45
Pneumatosis cystoides intestinalis in a patient with aseptic meningitis: a case report. 61
31471694 2019
46
Distinguishing Stevens-Johnson syndrome/toxic epidermal necrolysis from clinical mimickers during inpatient dermatologic consultation-A retrospective chart review. 61
31150704 2019
47
A case of recalcitrant acute generalized exanthematous pustulosis with Sjogren's syndrome: Successfully treated with low-dose cyclosporine. 61
31534735 2019
48
An unusual photodistributed acute generalized exanthematous pustulosis induced by terbinafine. 61
30955868 2019
49
Acute generalized exanthematous pustulosis in a child with fasciitis. 61
31569293 2019
50
Acute generalized exanthematous pustulosis and epidermal necrolysis differ in innate cytokine patterns. 61
31206897 2019
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Variations for Acute Generalized Exanthematous Pustulosis

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Expression for Acute Generalized Exanthematous Pustulosis

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Search GEO for disease gene expression data for Acute Generalized Exanthematous Pustulosis.
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Pathways for Acute Generalized Exanthematous Pustulosis

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Pathways related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.61 PTGS2 MX1 IL36G IL22 IL17F IL17A
2
PEDF Induced Signaling 63
Show member pathways
 13.14 PTGS2 IL36RN IL36G IL22 IL17F IL17A
3
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.34 PTGS2 IL36RN IL36G CXCL8
4
Cytokine Signaling in Immune system 65
Show member pathways
 12.28 PTGS2 MX1 IL36G IL22 IL17F IL17A
5
IL-17 Family Signaling Pathways 64
Show member pathways
 11.79 PTGS2 IL17F IL17A CXCL8
6
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.51 IL17F IL17A CXCL8
7
Th17 Differentiation 64
Show member pathways
 11.46 IL22 IL17F IL17A
8
Interleukin-4 and 13 signaling 65
11.31 PTGS2 IL17F IL17A CXCL8
9
Hepatitis C and Hepatocellular Carcinoma 1
11.23 PTGS2 CXCL8
10
Interleukin-10 signaling 65
11.2 PTGS2 CXCL8
11
Development and heterogeneity of the ILC family 1
11 IL22 IL17A
12
IL1 Signaling Pathway 66
10.89 IL36RN IL36G
13
Overview of nanoparticle effects 1
10.71 PTGS2 CXCL8
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GO Terms for Acute Generalized Exanthematous Pustulosis

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Cellular components related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 IL36RN IL36G IL22 IL17F IL17A CXCL8
2 extracellular space GO:0005615 9.1 IL36RN IL36G IL22 IL17F IL17A CXCL8

Biological processes related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.56 IL36RN IL36G IL17A CXCL8
2 cellular response to lipopolysaccharide GO:0071222 9.5 IL36RN IL36G CXCL8
3 inflammatory response GO:0006954 9.5 PTGS2 IL36RN IL36G IL22 IL17F IL17A
4 receptor internalization GO:0031623 9.46 MX1 CXCL8
5 positive regulation of interleukin-6 secretion GO:2000778 9.43 IL17F IL17A
6 inflammatory response to antigenic stimulus GO:0002437 9.4 IL36RN IL36G
7 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.37 IL17F IL17A
8 cytokine-mediated signaling pathway GO:0019221 9.17 PTGS2 IL36RN IL36G IL22 IL17F IL17A
9 interleukin-17-mediated signaling pathway GO:0097400 9.16 IL17F IL17A

Molecular functions related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 IL36RN IL36G IL22 IL17F IL17A CXCL8
2 interleukin-1 receptor binding GO:0005149 8.96 IL36RN IL36G
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Sources for Acute Generalized Exanthematous Pustulosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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