AGEP
MCID: ACT167
MIFTS: 43

Acute Generalized Exanthematous Pustulosis (AGEP)

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Acute Generalized Exanthematous Pustulosis

MalaCards integrated aliases for Acute Generalized Exanthematous Pustulosis:

Name: Acute Generalized Exanthematous Pustulosis 60 74
Agep 60 74
Pustular Drug Eruption 60
Toxic Pustuloderma 60

Characteristics:

Orphanet epidemiological data:

60
acute generalized exanthematous pustulosis
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 60  
Rare skin diseases


External Ids:

UMLS via Orphanet 75 C0853331 C0877055
Orphanet 60 ORPHA293173

Summaries for Acute Generalized Exanthematous Pustulosis

MalaCards based summary : Acute Generalized Exanthematous Pustulosis, also known as agep, is related to allergic contact dermatitis and colitis. An important gene associated with Acute Generalized Exanthematous Pustulosis is IL17A (Interleukin 17A), and among its related pathways/superpathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. The drugs Saxagliptin and Petrolatum have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and neutrophil, and related phenotype is digestive/alimentary.

Wikipedia : 77 Acute generalized exanthematous pustulosis (AGEP) (also known as pustular drug eruption and toxic... more...

Related Diseases for Acute Generalized Exanthematous Pustulosis

Diseases related to Acute Generalized Exanthematous Pustulosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 allergic contact dermatitis 30.5 CXCL8 IL17A
2 colitis 29.9 CXCL8 IL17A PTGS2
3 arthritis 29.6 CXCL8 IL17A PTGS2
4 rheumatoid arthritis 29.3 CXCL8 IL17A PTGS2
5 psoriasis 10.8
6 pustular psoriasis 10.7
7 psoriasis 14, pustular 10.5
8 severe cutaneous adverse reaction 10.4
9 dermatitis 10.4
10 contact dermatitis 10.4
11 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 10.4
12 leukemia 10.3
13 ulcerative colitis 10.3
14 pustulosis of palm and sole 10.3
15 myeloid leukemia 10.3
16 candidiasis 10.2 IL17A IL17F
17 nail disease 10.2 IL17A IL17F
18 autoimmune polyendocrine syndrome 10.2 IL17A IL22
19 nasopharyngitis 10.2 IL17A IL36RN
20 benign chronic pemphigus 10.1
21 small cell cancer of the lung 10.1
22 lung cancer 10.1
23 myeloma, multiple 10.1
24 pancreatic cancer 10.1
25 werner syndrome 10.1
26 psoriasis 7 10.1
27 psoriasis 11 10.1
28 psoriasis 13 10.1
29 polyarteritis nodosa, childhood-onset 10.1
30 glomerulonephritis 10.1
31 hemolytic anemia 10.1
32 hepatitis 10.1
33 osteonecrosis 10.1
34 erythema multiforme 10.1
35 drug allergy 10.1
36 mumps 10.1
37 optic neuritis 10.1
38 cystic echinococcosis 10.1
39 echinococcosis 10.1
40 neuritis 10.1
41 melanoma 10.1
42 acute pancreatitis 10.1
43 pancreatitis 10.1
44 influenza 10.1
45 lymphangitis 10.1
46 polyarteritis nodosa 10.1
47 hypoglycemia 10.1
48 drug reaction with eosinophilia and systemic symptoms 10.1
49 stevens-johnson syndrome/toxic epidermal necrolysis 10.1
50 cytomegalovirus infection 10.1

Graphical network of the top 20 diseases related to Acute Generalized Exanthematous Pustulosis:



Diseases related to Acute Generalized Exanthematous Pustulosis

Symptoms & Phenotypes for Acute Generalized Exanthematous Pustulosis

MGI Mouse Phenotypes related to Acute Generalized Exanthematous Pustulosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 8.92 IL17A IL17F PTGS2 WRN

Drugs & Therapeutics for Acute Generalized Exanthematous Pustulosis

Drugs for Acute Generalized Exanthematous Pustulosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Saxagliptin Approved 361442-04-8 11243969
2
Petrolatum Approved, Investigational Not Applicable 8009-03-8
3
Eslicarbazepine acetate Approved 75970-99-9, 236395-14-5 123618
4 Hypoglycemic Agents
5 HIV Protease Inhibitors
6 Hormones
7
protease inhibitors
8 Incretins
9 Hormone Antagonists
10 Dipeptidyl-Peptidase IV Inhibitors
11 Hormones, Hormone Substitutes, and Hormone Antagonists
12 Sodium Channel Blockers
13 Anticonvulsants
14 Diuretics, Potassium Sparing

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Risk of Hospitalization for Severe Hypersensitivity (Including Severe Skin Reactions) in Patients With Type 2 Diabetes Exposed to Oral Antidiabetic Treatments Completed NCT01086319
2 Ocular Safety Of Patients Receiving Macugen For Neovascular Age Related Macular Degeneration Completed NCT00460408 Macugen
3 Drug Patch Tests in Patients With Severe Cutaneous Adverse Reaction to Drugs (SCARs) Recruiting NCT03176342 Not Applicable
4 Severe Cutaneous Adverse Reactions in Thailand Recruiting NCT02574988
5 An Exploratory Study of Genetic and Clinical Factors for Serious Skin Reactions Among Users of Eslicarbazepine Acetate Recruiting NCT02520557
6 Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases Recruiting NCT01952275

Search NIH Clinical Center for Acute Generalized Exanthematous Pustulosis

Genetic Tests for Acute Generalized Exanthematous Pustulosis

Anatomical Context for Acute Generalized Exanthematous Pustulosis

MalaCards organs/tissues related to Acute Generalized Exanthematous Pustulosis:

42
Skin, Testes, Neutrophil, T Cells, Myeloid, Kidney, Smooth Muscle

Publications for Acute Generalized Exanthematous Pustulosis

Articles related to Acute Generalized Exanthematous Pustulosis:

(show top 50) (show all 412)
# Title Authors Year
1
Distinguishing pustular psoriasis and acute generalized exanthematous pustulosis (AGEP) on the basis of plasmacytoid dendritic cells (PDCs) and MxA protein. ( 30667074 )
2019
2
Case Report: Acute Generalized Exanthematous Pustulosis Caused by Praziquantel. ( 30675838 )
2019
3
Occupational acute generalized exanthematous pustulosis induced by disperse dyes in textile. ( 30756392 )
2019
4
Acute generalized exanthematous pustulosis (AGEP) and psoriasis: what can be learned from co-morbidities. A comparative study. ( 30762030 )
2019
5
Acute generalized exanthematous pustulosis induced by iomeprol with cross-reactivity to other iodinated contrast agents and mild reaction after rechallenge with iopromide and oral corticosteroid premedication. ( 30762885 )
2019
6
Accidental re-exposure causing repeated severe acute generalized exanthematous pustulosis. ( 30817022 )
2019
7
Acute generalized exanthematous pustulosis induced by a digestive enzyme drug, Festal<sup>Ar</sup>. ( 29341242 )
2018
8
First case report of acute generalized exanthematous pustulosis (AGEP) caused by gadolinium confirmed by patch testing. ( 29341190 )
2018
9
Acute Generalized Exanthematous Pustulosis Simulating Toxic Epidermal Necrolysis: Overlapping Processes. ( 29402393 )
2018
10
A novel WRN mutation identified in a patient with Werner syndrome and acute generalized exanthematous pustulosis. ( 29952303 )
2018
11
Acute generalized exanthematous pustulosis induced by oxacillin confirmed by patch testing. ( 29655194 )
2018
12
Acute generalized exanthematous pustulosis caused by ibuprofen-Diagnosis confirmed by patch testing. ( 29572854 )
2018
13
Acute generalized exanthematous pustulosis simulating Stevens-Johnson syndrome/toxic epidermal necrolysis associated with the use of vismodegib. ( 29387760 )
2018
14
Case of generalized pustular psoriasis that might have progressed from terbinafine-induced acute generalized exanthematous pustulosis. ( 29766566 )
2018
15
Acute generalized exanthematous pustulosis due to terbinafine. ( 29786933 )
2018
16
Acute Generalized Exanthematous Pustulosis Induced by Docetaxel and Recurrent With Letrozole: A Case Report. ( 29980428 )
2018
17
Two cases of annular acute generalized exanthematous pustulosis induced by terbinafine. ( 29336314 )
2018
18
Varenicline-induced acute generalized exanthematous pustulosis confirmed by patch testing. ( 29265452 )
2018
19
Codeine-induced acute generalized exanthematous pustulosis without IL36RN mutations. ( 29914290 )
2018
20
Acute generalized exanthematous pustulosis associated with Helicobacter pylori eradication therapy with elevated serum procalcitonin. ( 29400303 )
2018
21
A Plethora of Pustules: Acute Generalized Exanthematous Pustulosis. ( 29425705 )
2018
22
A Case of Acute Generalized Exanthematous Pustulosis after Injection of an Erythropoiesis-Stimulating Agent. ( 29386844 )
2018
23
A Case of Ceftriaxone-Induced Acute Generalized Exanthematous Pustulosis/Generalized Pustular Psoriasis Overlap. ( 29681811 )
2018
24
Acute generalized exanthematous pustulosis caused by pantoprazole. ( 29894542 )
2018
25
Acute generalized exanthematous pustulosis with multisystem manifestations: Pinpoint pustules and purulent lakes. ( 29273137 )
2018
26
Acute generalized exanthematous pustulosis induced by mianserin. ( 30129529 )
2018
27
Cyclosporine for corticosteroid-refractory acute generalized exanthematous pustulosis due to hydroxychloroquine. ( 30152569 )
2018
28
Acute generalized exanthematous pustulosis induced by terbinafine in a child confirmed by patch testing. ( 30255495 )
2018
29
Culprit drugs induce specific IL-36 overexpression in Acute Generalized Exanthematous Pustulosis. ( 30395846 )
2018
30
Cannabidiol-Induced Acute Generalized Exanthematous Pustulosis. ( 30422887 )
2018
31
Cephalexin-induced acute generalized exanthematous pustulosis. ( 30464809 )
2018
32
Cefixime-associated acute generalized exanthematous pustulosis: Rare cases in India. ( 30505057 )
2018
33
Acute generalized exanthematous pustulosis (AGEP)-like contact dermatitis resulting from topical therapy in a polysensitized patient. ( 30578535 )
2018
34
Acute generalized exanthematous pustulosis: a case series of 13 patients in Brazil. ( 29992639 )
2018
35
AGEP from a dog bite treated with Ibuprofen. ( 30238914 )
2018
36
AGEP overlap induced by hydroxychloroquine: a case report and literature review. ( 30559945 )
2018
37
Is neutrophilic desquamative erythroderma a form of acute generalized exanthematous pustulosis? ( 29224230 )
2017
38
Sorafenib-induced Acute Generalized Exanthematous Pustulosis: An Increasing Association? ( 28262110 )
2017
39
Rapid Involution of Pustules during Topical Steroid Treatment of Acute Generalized Exanthematous Pustulosis. ( 28559812 )
2017
40
Acute generalized exanthematous pustulosis: clinical characteristics, etiologic associations, treatments, and outcomes in a series of 28 patients at Mayo Clinic, 1996-2013. ( 28084022 )
2017
41
Severe drug-induced kidney injury in acute generalized exanthematous pustulosis. ( 29222845 )
2017
42
Acute generalized exanthematous pustulosis caused by an iodinated contrast radiocontrast medium for computed tomography arthrography of the knee. ( 28497630 )
2017
43
Acute generalized exanthematous pustulosis associated with ipilimumab and nivolumab. ( 28430376 )
2017
44
Acute Generalized Exanthematous Pustulosis. ( 28361791 )
2017
45
Non-pigmenting fixed drug eruption with mixed features of acute generalized exanthematous pustulosis induced by pseudoephedrine: a case report. ( 28703347 )
2017
46
Bendamustine-Induced Acute Generalized Exanthematous Pustulosis Confirmed by Patch Testing. ( 28617679 )
2017
47
Acute generalized exanthematous pustulosis induced by hydroxychloroquine: a case with atypical clinical presentation. ( 29186260 )
2017
48
Acute Generalized Exanthematous Pustulosis (AGEP) associated to Epstein-Barr Virus (EBV) infection reactivation. ( 28704988 )
2017
49
Oral lesions of acute generalized exanthematous pustulosis. ( 28952158 )
2017
50
Acute generalized exanthematous pustulosis and polyarthritis associated with a novel CARD14 mutation. ( 28776328 )
2017

Variations for Acute Generalized Exanthematous Pustulosis

Expression for Acute Generalized Exanthematous Pustulosis

Search GEO for disease gene expression data for Acute Generalized Exanthematous Pustulosis.

Pathways for Acute Generalized Exanthematous Pustulosis

Pathways related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.07 CXCL8 IL17A IL17F IL22 IL36RN PTGS2
2
Show member pathways
12.88 CXCL8 IL17A IL17F IL22 PTGS2
3
Show member pathways
12.22 IL17A IL17F IL22
4
Show member pathways
11.83 CXCL8 IL36RN PTGS2
5
Show member pathways
11.73 CXCL8 IL17A IL22
6
Show member pathways
11.61 IL17A IL17F IL22
7
Show member pathways
11.59 CXCL8 IL17A IL17F PTGS2
8 11.57 CXCL8 PTGS2
9 11.54 CXCL8 IL17A
10 11.48 IL17A IL22
11
Show member pathways
11.45 CXCL8 PTGS2
12 11.41 IL17A PTGS2
13
Show member pathways
11.35 CXCL8 PTGS2
14
Show member pathways
11.3 CXCL8 IL17A IL17F
15 11.23 CXCL8 PTGS2
16 11.18 CXCL8 PTGS2
17 10.98 IL17A IL22
18 10.98 CXCL8 IL17A IL17F PTGS2
19 10.86 CXCL8 IL17A IL22
20 10.71 CXCL8 PTGS2

GO Terms for Acute Generalized Exanthematous Pustulosis

Cellular components related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 CXCL8 IL17A IL17F IL22 IL36RN
2 extracellular space GO:0005615 9.02 CXCL8 IL17A IL17F IL22 IL36RN

Biological processes related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.65 CXCL8 IL17A IL36RN
2 regulation of signaling receptor activity GO:0010469 9.55 CXCL8 IL17A IL17F IL22 IL36RN
3 neutrophil chemotaxis GO:0030593 9.46 CXCL8 IL36RN
4 cellular response to interleukin-1 GO:0071347 9.43 CXCL8 IL17A
5 inflammatory response GO:0006954 9.43 CXCL8 IL17A IL17F IL22 IL36RN PTGS2
6 response to glucocorticoid GO:0051384 9.4 IL22 PTGS2
7 positive regulation of interleukin-6 secretion GO:2000778 9.37 IL17A IL17F
8 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.32 IL17A IL17F
9 interleukin-17-mediated signaling pathway GO:0097400 9.26 IL17A IL17F
10 cytokine-mediated signaling pathway GO:0019221 9.1 CXCL8 IL17A IL17F IL22 IL36RN PTGS2

Molecular functions related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CXCL8 IL17A IL17F IL22 IL36RN

Sources for Acute Generalized Exanthematous Pustulosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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