AGEP
MCID: ACT167
MIFTS: 37

Acute Generalized Exanthematous Pustulosis (AGEP)

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Acute Generalized Exanthematous Pustulosis

MalaCards integrated aliases for Acute Generalized Exanthematous Pustulosis:

Name: Acute Generalized Exanthematous Pustulosis 58 71
Agep 58 71
Pustular Drug Eruption 58
Toxic Pustuloderma 58

Characteristics:

Orphanet epidemiological data:

58
acute generalized exanthematous pustulosis
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

UMLS via Orphanet 72 C0853331 C0877055
Orphanet 58 ORPHA293173
UMLS 71 C0863129 C0877055

Summaries for Acute Generalized Exanthematous Pustulosis

MalaCards based summary : Acute Generalized Exanthematous Pustulosis, also known as agep, is related to pustulosis of palm and sole and allergic contact dermatitis. An important gene associated with Acute Generalized Exanthematous Pustulosis is IL36RN (Interleukin 36 Receptor Antagonist), and among its related pathways/superpathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. The drugs Petrolatum and Eslicarbazepine acetate have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and lung.

Wikipedia : 74 Acute generalized exanthematous pustulosis (AGEP) (also known as pustular drug eruption and toxic... more...

Related Diseases for Acute Generalized Exanthematous Pustulosis

Diseases related to Acute Generalized Exanthematous Pustulosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 193)
# Related Disease Score Top Affiliating Genes
1 pustulosis of palm and sole 31.4 IL36RN IL17A CXCL8
2 allergic contact dermatitis 30.8 IL17A CXCL8
3 erythema multiforme 30.8 PTGS2 CXCL8
4 pityriasis rubra pilaris 30.6 IL36RN IL17A
5 common cold 30.4 IL17A CXCL8
6 keratoconjunctivitis 30.4 IL17A CXCL8
7 psoriasis 30.3 IL36RN IL22 IL17F IL17A CXCL8
8 ulcerative colitis 30.2 IL22 IL17A CXCL8
9 bacterial infectious disease 30.1 MX1 IL17A CXCL8
10 pharyngitis 30.1 PTGS2 CXCL8
11 periodontitis 29.7 PTGS2 IL17A CXCL8
12 autoimmune disease 29.5 IL22 IL17F IL17A CXCL8
13 skin disease 29.4 MX1 IL36RN IL22 IL17A CXCL8
14 colitis 29.3 PTGS2 IL22 IL17A CXCL8
15 rheumatoid arthritis 29.0 PTGS2 IL22 IL17A CXCL8
16 exanthem 11.0
17 pustular psoriasis 10.9
18 stevens-johnson syndrome/toxic epidermal necrolysis 10.9
19 severe cutaneous adverse reaction 10.8
20 allergic hypersensitivity disease 10.7
21 psoriasis 14, pustular 10.7
22 hypereosinophilic syndrome 10.7
23 vasculitis 10.6
24 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 10.6
25 drug allergy 10.6
26 erythema multiforme major 10.6
27 dermatitis 10.4
28 contact dermatitis 10.4
29 cytokine deficiency 10.4
30 myeloma, multiple 10.3
31 optic neuritis 10.3
32 acute cystitis 10.3
33 toxic shock syndrome 10.3
34 urticaria 10.3
35 neuritis 10.3
36 purpura 10.3
37 syphilis 10.3
38 spongiotic dermatitis 10.3
39 subcorneal pustular dermatosis 10.3
40 myeloid leukemia 10.3
41 pemphigus 10.3
42 47,xyy 10.3
43 drug reaction with eosinophilia and systemic symptoms 10.3
44 angelucci's syndrome 10.3 IL17A CXCL8
45 neurosyphilis 10.3 IL17A CXCL8
46 transverse myelitis 10.2 IL17A CXCL8
47 myelitis 10.2 IL17A CXCL8
48 mycetoma 10.2 IL17A CXCL8
49 pyoderma 10.2 IL36RN CXCL8
50 relapsing polychondritis 10.2 IL17A CXCL8

Graphical network of the top 20 diseases related to Acute Generalized Exanthematous Pustulosis:



Diseases related to Acute Generalized Exanthematous Pustulosis

Symptoms & Phenotypes for Acute Generalized Exanthematous Pustulosis

Drugs & Therapeutics for Acute Generalized Exanthematous Pustulosis

Drugs for Acute Generalized Exanthematous Pustulosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Petrolatum Approved, Investigational 8009-03-8
2
Eslicarbazepine acetate Approved 236395-14-5, 75970-99-9 123618
3 Sodium Channel Blockers
4 Anticonvulsants
5 Diuretics, Potassium Sparing
6 Immunoglobulin A

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Drug Patch Tests, Enzyme-linked Immunosorbent Spot Assay (Elispot) and Lymphocyte Transformation Tests in Patients With Severe Cutaneous Adverse Reaction to Drugs (SCARs) Unknown status NCT03176342
2 The Multicenter Registry of Patients With Severe Cutaneous Adverse Reactions Among Tertiary Medical Institutes in Thailand Recruiting NCT02574988
3 An Exploratory Case-Control Study of Genetic and Clinical Factors for Serious Cutaneous Reactions Among Users of Eslicarbazepine Acetate Recruiting NCT02520557
4 Assessment of the Enrichment of Rare Coding Genetic Variants in Patients Affected by Neutrophil-Mediated Inflammatory Dermatoses Recruiting NCT01952275
5 Adverse Cutaneous Drug Reactions Collection of Clinical Data and Biological Samples Recruiting NCT03659227

Search NIH Clinical Center for Acute Generalized Exanthematous Pustulosis

Genetic Tests for Acute Generalized Exanthematous Pustulosis

Anatomical Context for Acute Generalized Exanthematous Pustulosis

MalaCards organs/tissues related to Acute Generalized Exanthematous Pustulosis:

40
Testes, Skin, Lung, Neutrophil, T Cells, Myeloid, Kidney

Publications for Acute Generalized Exanthematous Pustulosis

Articles related to Acute Generalized Exanthematous Pustulosis:

(show top 50) (show all 682)
# Title Authors PMID Year
1
Acute generalized exanthematous pustulosis induced by hydroxychloroquine successfully treated with etretinate. 61
31840277 2020
2
[Acute localized exanthematous pustulosis following heparin calcium injections]. 61
32029300 2020
3
Interleukin 17 as a therapeutic target of acute generalized exanthematous pustulosis (AGEP). 61
32014613 2020
4
Acute generalized exanthematous pustulosis induced by mycophenolate mofetil: a case complicated with pemphigus foliaceus. 61
31996549 2020
5
Aetiopathogenesis of severe cutaneous adverse reactions (SCARs) in children: A 9-year experience in a tertiary care paediatric hospital setting. 61
31608511 2020
6
Coexisting mutations in CARD14 and NUDT15 detected in a young female with azathioprine hypersensitivity syndrome manifested as acute generalized exanthematous pustulosis. 61
31994212 2020
7
Systemic allergic dermatitis presenting as acute generalized exanthematous pustulosis due to betamethasone sodium phosphate. 61
31821599 2019
8
Contrast media and cutaneous reactions. Part 2: Delayed hypersensitivity reactions to iodinated contrast media. 61
31162717 2019
9
Accidental re-exposure causing repeated severe acute generalized exanthematous pustulosis. 61
30817022 2019
10
Cetirizine induced acute generalized exanthematous pustulosis confirmed by patch testing. 61
31782151 2019
11
Drug-induced severe cutaneous adverse reactions: Determine the cause and prevention. 61
31400461 2019
12
Acute Generalized Exanthematous Pustulosis Caused by the Combination of Pembrolizumab Plus Chemotherapy in a Patient With Squamous-Cell Carcinoma. 61
31874730 2019
13
Acute generalized exanthematous pustulosis induced by amoxicillin/clavulanic acid, manifesting as severe laryngeal edema. 61
31321789 2019
14
Pneumatosis cystoides intestinalis in a patient with aseptic meningitis: a case report. 61
31471694 2019
15
Acute Generalized Exanthematous Pustulosis Due to Clavulanic Acid. 61
31631017 2019
16
First case report of acute generalized exanthematous pustulosis (AGEP) caused by mifepristone. 61
31626328 2019
17
An unusual photodistributed acute generalized exanthematous pustulosis induced by terbinafine. 61
30955868 2019
18
Acute generalized exanthematous pustulosis and epidermal necrolysis differ in innate cytokine patterns. 61
31206897 2019
19
Acute generalized exanthematous pustulosis in a child with fasciitis. 61
31569293 2019
20
A case of recalcitrant acute generalized exanthematous pustulosis with Sjogren's syndrome: Successfully treated with low-dose cyclosporine. 61
31534735 2019
21
Distinguishing Stevens-Johnson syndrome/toxic epidermal necrolysis from clinical mimickers during inpatient dermatologic consultation-A retrospective chart review. 61
31150704 2019
22
Dabigatran-associated Acute Generalized Exanthematous Pustulosis (AGEP) in a psoriatic patient undergoing Ixekizumab and its pathogenetic mechanism. 61
31286621 2019
23
Acute generalized exanthematous pustulosis and psoriasis: what can be learned from comorbidities. 61
30762030 2019
24
Mechanisms of Severe Cutaneous Adverse Reactions: Recent Advances. 61
31020549 2019
25
Making a diagnosis in severe cutaneous drug hypersensitivity reactions. 61
31247634 2019
26
IL-17E (IL-25) Enhances Innate Immune Responses during Skin Inflammation. 61
30738055 2019
27
[Warning symptoms skin: cutaneous manifestation of drug allergy]. 61
31282839 2019
28
Acute Generalized Exanthematous Pustulosis to Amoxicillin. 61
31261223 2019
29
Acute generalized exanthematous pustulosis due to ceftriaxone: Report of a pediatric case with recurrence after positive patch test. 61
31050838 2019
30
Acute generalized exanthematous pustulosis induced by iomeprol with cross-reactivity to other iodinated contrast agents and mild reactions after rechallenge with iopromide and oral corticosteroid premedication. 61
30762885 2019
31
Occupational acute generalized exanthematous pustulosis induced by disperse dyes in a textile. 61
30756392 2019
32
Acute generalized exanthematous pustulosis associated with anti-interferon-γ neutralizing autoantibody-positive disseminated nontuberculous mycobacterial infection. 61
31251217 2019
33
Outpatient management and follow-up recommendations for adverse drug reactions: guidelines for posthospitalization care. 61
31233575 2019
34
Acute generalized exanthematous pustulosis (AGEP)-like contact dermatitis resulting from topical therapy in a polysensitized patient. 61
30578535 2019
35
Distinguishing pustular psoriasis and acute generalized exanthematous pustulosis on the basis of plasmacytoid dendritic cells and MxA protein. 61
30667074 2019
36
Wirksamkeit des IL-17-Hemmers SECUKINUMAB bei akuter generalisierter exanthematische Pustulose (AGEP). 61
31037850 2019
37
Culprit Drugs Induce Specific IL-36 Overexpression in Acute Generalized Exanthematous Pustulosis. 61
30395846 2019
38
Ciprofloxacin-Induced Bullae of the Lower Extremity: A Case of a Fixed Drug Reaction. 61
31135195 2019
39
Case Report: Acute Generalized Exanthematous Pustulosis Caused by Praziquantel. 61
30675838 2019
40
Hydrochlorothizide-induced acute generalised exanthematous pustulosis presenting with bilateral periorbital impetigo. 61
30755424 2019
41
Acute generalized exanthematous pustulosis induced by terbinafine in a child confirmed by patch testing. 61
30255495 2019
42
Acute generalized exanthematous pustulosis associated with Epstein-Barr virus infection reactivation. 61
28704988 2019
43
Acute generalized exanthematous pustulosis: a case series of 13 patients in Brazil. 61
29992639 2019
44
Pustular DRESS Syndrome Secondary to Hydroxychloroquine With EBV Reactivation 61
30811149 2019
45
First presentation of Sneddon-Wilkinson disease with unexpected immunoglobulin A gammopathy: A case report and review of the literature. 61
30728980 2019
46
The First Pediatric Case of Acute Generalized Exanthematous Pustulosis Caused by Hydroxychloroquine. 61
31067554 2019
47
Controversies in drug allergy: Testing for delayed reactions. 61
30573342 2019
48
Hypersensitivity Reactions in Serious Adverse Events Reported for Paracetamol in the EudraVigilance Database, 2007⁻2018. 61
30658389 2019
49
Clinical Phenotypes of Severe Cutaneous Drug Hypersensitivity Reactions. 61
31696807 2019
50
An Update on the Management of Severe Cutaneous Drug Hypersensitivity Reactions. 61
31692425 2019

Variations for Acute Generalized Exanthematous Pustulosis

Expression for Acute Generalized Exanthematous Pustulosis

Search GEO for disease gene expression data for Acute Generalized Exanthematous Pustulosis.

Pathways for Acute Generalized Exanthematous Pustulosis

Pathways related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.19 PTGS2 IL36RN IL22 IL17F IL17A CXCL8
2
Show member pathways
12.74 PTGS2 MX1 IL22 IL17F IL17A CXCL8
3
Show member pathways
12.24 IL22 IL17F IL17A
4
Show member pathways
11.9 MX1 IL17A CXCL8
5
Show member pathways
11.85 PTGS2 IL36RN CXCL8
6
Show member pathways
11.61 IL22 IL17F IL17A
7
Show member pathways
11.59 PTGS2 IL17F IL17A CXCL8
8
Show member pathways
11.4 IL17F IL17A CXCL8
9
Show member pathways
11.34 PTGS2 CXCL8
10 11.2 PTGS2 CXCL8
11 11.17 PTGS2 CXCL8
12 10.98 PTGS2 IL17F IL17A CXCL8
13 10.96 IL22 IL17A
14 10.68 PTGS2 CXCL8

GO Terms for Acute Generalized Exanthematous Pustulosis

Cellular components related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 IL36RN IL22 IL17F IL17A CXCL8

Biological processes related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.43 PTGS2 IL36RN IL22 IL17F IL17A CXCL8
2 receptor internalization GO:0031623 9.37 MX1 CXCL8
3 positive regulation of interleukin-6 secretion GO:2000778 9.32 IL17F IL17A
4 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.26 IL17F IL17A
5 interleukin-17-mediated signaling pathway GO:0097400 9.16 IL17F IL17A
6 cytokine-mediated signaling pathway GO:0019221 9.1 PTGS2 IL36RN IL22 IL17F IL17A CXCL8

Molecular functions related to Acute Generalized Exanthematous Pustulosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 IL36RN IL22 IL17F IL17A CXCL8

Sources for Acute Generalized Exanthematous Pustulosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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