MCID: ACT048
MIFTS: 31

Acute Gonococcal Cervicitis

Categories: Reproductive diseases

Aliases & Classifications for Acute Gonococcal Cervicitis

MalaCards integrated aliases for Acute Gonococcal Cervicitis:

Name: Acute Gonococcal Cervicitis 12 15 70
Gonococcal Cervicitis 12 70
Acute Gonorrhea of Cervix 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10615
ICD9CM 34 098.15
SNOMED-CT 67 20943002
UMLS 70 C0153195 C0812378

Summaries for Acute Gonococcal Cervicitis

Disease Ontology : 12 An acute cervicitis that is caused by gonorrhea.

MalaCards based summary : Acute Gonococcal Cervicitis, also known as gonococcal cervicitis, is related to cervicitis and urethritis. An important gene associated with Acute Gonococcal Cervicitis is SCARF1 (Scavenger Receptor Class F Member 1), and among its related pathways/superpathways are Allograft rejection and JAK-STAT signaling pathway. Affiliated tissues include cervix, and related phenotypes are hematopoietic system and immune system

Related Diseases for Acute Gonococcal Cervicitis

Diseases related to Acute Gonococcal Cervicitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 396)
# Related Disease Score Top Affiliating Genes
1 cervicitis 30.3 IL6 IL10 CXCL8
2 urethritis 29.7 IL6 IL10 CXCL8
3 chlamydia 29.3 IL6 IL4 IL10 CXCL8
4 chronic gonorrhea of cervix 11.4
5 tropical endomyocardial fibrosis 10.1 IL4 IL10
6 endomyocardial fibrosis 10.1 IL4 IL10
7 opisthorchiasis 10.1 IL4 CXCL8
8 chromium allergic contact dermatitis 10.1 IL4 IL10
9 neurosyphilis 10.0 IL10 CXCL8
10 immune deficiency disease 10.0
11 human immunodeficiency virus type 1 10.0
12 ectopic pregnancy 10.0
13 pelvic inflammatory disease 10.0
14 47,xyy 10.0
15 cow milk allergy 10.0 IL4 IL10
16 metal allergy 10.0 IL4 IL10
17 autoimmune hepatitis type 1 10.0 IL4 IL10
18 loiasis 10.0 IL4 IL10
19 periapical granuloma 10.0 IL4 CXCL8
20 mikulicz disease 10.0 IL4 IL10
21 basidiobolomycosis 10.0 IL4 IL10
22 orofacial granulomatosis 10.0 IL4 IL10
23 trichinosis 10.0 IL4 IL10
24 mycetoma 10.0 IL10 CXCL8
25 blepharitis 10.0 IL4 CXCL8
26 timothy grass allergy 10.0 IL4 IL10
27 nickel allergic contact dermatitis 10.0 IL4 IL10
28 primary peritoneal carcinoma 10.0 IL10 CXCL8
29 mansonelliasis 10.0 IL10 CXCL8
30 toxocariasis 10.0 IL4 IL10
31 dacryoadenitis 10.0 IL4 IL10
32 mucocutaneous leishmaniasis 10.0 IL4 IL10
33 vulvovaginitis 10.0 IL10 CXCL8
34 elephantiasis 10.0 IL4 IL10
35 beta-lactam allergy 10.0 IL4 IL10
36 inflammatory bowel disease 18 10.0 IL4 IL10
37 scabies 10.0 IL10 CXCL8
38 clonorchiasis 10.0 IL10 CXCL8
39 egg allergy 10.0 IL4 IL10
40 filarial elephantiasis 10.0 IL4 IL10
41 legume allergy 10.0 IL4 IL10
42 fruit allergy 10.0 IL4 IL10
43 eosinophilic meningitis 10.0 IL4 IL10
44 penicillin allergy 10.0 IL4 IL10
45 acute graft versus host disease 10.0 IL4 IL10
46 urinary schistosomiasis 10.0 IL4 IL10
47 intestinal schistosomiasis 10.0 IL4 IL10
48 status asthmaticus 10.0 IL10 CXCL8
49 genital herpes 10.0 IL4 IL10
50 idiopathic anterior uveitis 9.9 IL6 CXCL8

Graphical network of the top 20 diseases related to Acute Gonococcal Cervicitis:



Diseases related to Acute Gonococcal Cervicitis

Symptoms & Phenotypes for Acute Gonococcal Cervicitis

MGI Mouse Phenotypes related to Acute Gonococcal Cervicitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.5 ASGR1 CEACAM1 IL10 IL4 IL6 LY96
2 immune system MP:0005387 9.17 ASGR1 CEACAM1 IL10 IL4 IL6 LY96

Drugs & Therapeutics for Acute Gonococcal Cervicitis

Search Clinical Trials , NIH Clinical Center for Acute Gonococcal Cervicitis

Genetic Tests for Acute Gonococcal Cervicitis

Anatomical Context for Acute Gonococcal Cervicitis

MalaCards organs/tissues related to Acute Gonococcal Cervicitis:

40
Cervix

Publications for Acute Gonococcal Cervicitis

Articles related to Acute Gonococcal Cervicitis:

(show all 50)
# Title Authors PMID Year
1
Current status of Neisseria gonorrhoeae cervicitis in pregnant women in Japan. 61
30730922 2019
2
Transcriptome Analysis of Neisseria gonorrhoeae during Natural Infection Reveals Differential Expression of Antibiotic Resistance Determinants between Men and Women. 61
29950382 2018
3
Epidemiological and clinical characteristics of patients attending STI clinics in Tuscany, Italy: a multicenter report on new infections in 2011. 61
24990280 2015
4
High bacterial loads of Ureaplasma may be associated with non-specific cervicitis. 61
25017795 2014
5
Subclinical pelvic inflammatory disease and infertility. 61
22678036 2012
6
The Pathobiology of Neisseria gonorrhoeae Lower Female Genital Tract Infection. 61
21747805 2011
7
Gonococcal cervicitis: a role for biofilm in pathogenesis. 61
18973432 2008
8
The role of complement in gonococcal infection of cervical epithelia. 61
19388166 2008
9
Conserved regions from Neisseria gonorrhoeae pilin are immunosilent and not immunosuppressive. 61
17562775 2007
10
Fluoroquinolone-resistant Neisseria gonorrhoeae in Bali, Indonesia: 2004. 61
16601661 2006
11
Risk assessment at the primary health care level in Moshi, Tanzania: limits in predicting sexually transmitted infections among women. 61
20353133 2006
12
Variability of bacterial vaginosis over 6- to 12-month intervals. 61
16543864 2006
13
[Clinical observation on treatment of non-gonococcal cervicitis by integrative medicine]. 61
15892287 2005
14
The molecular mechanisms used by Neisseria gonorrhoeae to initiate infection differ between men and women. 61
15489357 2004
15
Associations among human leukocyte antigen (HLA) class II DQ variants, bacterial sexually transmitted diseases, endometritis, and fertility among women with clinical pelvic inflammatory disease. 61
15107633 2004
16
The antimicrobial defense mechanism of the female urethra: a reassessment. 61
12131279 2002
17
Gonococcal cervicitis is associated with reduced systemic CD8+ T cell responses in human immunodeficiency virus type 1-infected and exposed, uninfected sex workers. 61
11992292 2002
18
Genitourinary infections and their association with preterm labor. 61
11820488 2002
19
HIV infection among sex workers in Accra: need to target new recruits entering the trade. 61
11707673 2001
20
Neisseria gonorrhoeae elicits membrane ruffling and cytoskeletal rearrangements upon infection of primary human endocervical and ectocervical cells. 61
10948165 2000
21
Acute sexually transmitted infections increase human immunodeficiency virus type 1 plasma viremia, increase plasma type 2 cytokines, and decrease CD4 cell counts. 61
10915076 2000
22
Cytokine and antibody responses in women infected with Neisseria gonorrhoeae: effects of concomitant infections. 61
9728543 1998
23
[Survey of sexually transmitted diseases in the region of Rio Cuarto]. 61
9922478 1998
24
Chlamydial and gonococcal cervicitis in HIV-seropositive and HIV-seronegative pregnant women in Bangkok: prevalence, risk factors, and relation to perinatal HIV transmission. 61
9339966 1997
25
Hormonal contraception, vitamin A deficiency, and other risk factors for shedding of HIV-1 infected cells from the cervix and vagina. 61
9314871 1997
26
Grepafloxacin. 61
9129868 1997
27
Identifying cervical infection among pregnant women in Nairobi, Kenya: limitations of risk assessment and symptom-based approaches. 61
8976848 1996
28
Cost-effectiveness decision analysis of intramuscular ceftriaxone versus oral cefixime in adolescents with gonococcal cervicitis. 61
8599487 1996
29
Sexual contact tracing outcome in adolescent chlamydial and gonococcal cervicitis cases. 61
8750422 1996
30
HIV-1 prevalence and risk factors among sexually transmitted disease clinic attenders in Trinidad. 61
7794544 1995
31
Efficacy of nonoxynol 9 contraceptive sponge use in preventing heterosexual acquisition of HIV in Nairobi prostitutes. 61
1320133 1992
32
Prostitution in Sheffield: differences between prostitutes. 61
3224974 1988
33
Epidemiologic and clinical studies of Chlamydia trachomatis infection in northeastern Poland. 61
3067389 1988
34
[Epidemiological and therapeutic studies on gonococcal infections--one shot therapy by spectinomycin--[Sapporo Clinical Research Group for STD]]. 61
2953180 1987
35
Chlamydia trachomatis infections in Japan. 61
3829086 1986
36
Limulus lysate assay for gonorrhea. 61
6829395 1983
37
Post-gonococcal cervicitis and post-gonococcal urethritis. 61
7104660 1982
38
Sensitivity, specificity, and predictive values of the Limulus lysate assay for detection of exclusion of gonococcal cervicitis. 61
6809791 1982
39
Gynecological chlamydial infections. 61
7044982 1982
40
Post-gonococcal cervicitis and post-gonococcal urethritis. A study of their epidemiological correlation and the role of Chlamydia trachomatis in their aetiology. 61
7326554 1981
41
Gonorrhea and female infertility in rural Uganda. 61
7468680 1980
42
Rapid presumptive diagnosis of gonococcal cervicitis by the limulus lysate assay. 61
6770690 1980
43
Resistance to gonorrhea possibly mediated by the genital microbial flora. 61
6767455 1980
44
Trichomonas vaginalis: reevaluation of its clinical presentation and laboratory diagnosis. 61
6965976 1980
45
Cefoxitin in the treatment of gonorrhea. 61
119328 1979
46
Secretory antibody response of the cervix to infection with Neisseria gonorrhoeae. 61
114196 1979
47
Secretory IgA antibody responses to Neisseria gonorrhoeae in the genital secretions of infected females. 61
812926 1976
48
Comparison of trimethoprim-sulfamethoxazole with penicillin and tetracycline in the treatment of uncomplicated gonorrhea in women. 61
805649 1975
49
Current treatment of gonococcal cervicitis. 61
18906728 1948
50
ELECTROTHERAPY IN NON-GONOCOCCAL CERVICITIS. 61
20774404 1929

Variations for Acute Gonococcal Cervicitis

Expression for Acute Gonococcal Cervicitis

Search GEO for disease gene expression data for Acute Gonococcal Cervicitis.

Pathways for Acute Gonococcal Cervicitis

Pathways related to Acute Gonococcal Cervicitis according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.61 IL6 IL4 IL10 CXCL8
2
Show member pathways
12.21 IL6 IL4 IL10
3
Show member pathways
12.13 IL6 IL4 CXCL8
4
Show member pathways
12.13 IL6 IL10 CXCL8
5
Show member pathways
12.12 LY96 IL6 CXCL8
6
Show member pathways
12.06 LY96 IL6 CXCL8
7
Show member pathways
12.05 LY96 IL4 IL10
8
Show member pathways
12.01 IL6 IL4 IL10 CXCL8
9 11.96 IL6 IL10 CXCL8
10
Show member pathways
11.89 LY96 IL6 IL4 CXCL8
11 11.87 IL6 IL10 CXCL8
12 11.79 IL6 IL4 CXCL8
13 11.71 IL6 IL10 CXCL8
14
Show member pathways
11.65 LY96 IL6 CXCL8
15 11.62 IL6 IL4 IL10 CEACAM1
16 11.57 IL6 IL4 CXCL8
17 11.51 IL6 IL4 IL10 CXCL8
18 11.45 IL6 IL4 IL10
19 11.41 IL6 IL4 CXCL8
20 11.28 IL6 IL10 CXCL8
21 11.22 IL6 IL10
22 11.19 IL6 IL10
23 11.17 IL6 CXCL8
24 11.14 LY96 IL6 IL10 CXCL8
25 11.13 IL6 IL4
26 11.03 IL4 IL10
27 10.96 IL6 IL4 IL10
28 10.87 IL6 CXCL8
29 10.79 IL6 IL4 IL10 CXCL8
30 10.63 IL6 IL4
31 10.61 IL6 IL4 IL10 CXCL8

GO Terms for Acute Gonococcal Cervicitis

Cellular components related to Acute Gonococcal Cervicitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.17 LY96 IL6 IL4 IL10 CXCL8 CEACAM1

Biological processes related to Acute Gonococcal Cervicitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.73 IL6 IL4 IL10 CXCL8
2 cytokine-mediated signaling pathway GO:0019221 9.56 IL6 IL4 IL10 CXCL8
3 positive regulation of interleukin-10 production GO:0032733 9.52 IL6 IL4
4 negative regulation of endothelial cell apoptotic process GO:2000352 9.51 IL4 IL10
5 liver regeneration GO:0097421 9.49 IL6 IL10
6 positive regulation of JAK-STAT cascade GO:0046427 9.48 IL6 IL10
7 positive regulation of immunoglobulin production GO:0002639 9.46 IL6 IL10
8 positive regulation of MHC class II biosynthetic process GO:0045348 9.4 IL4 IL10
9 response to molecule of bacterial origin GO:0002237 9.37 IL10 CXCL8
10 negative regulation of interleukin-1 production GO:0032692 9.32 IL10 CEACAM1
11 type 2 immune response GO:0042092 9.16 IL4 IL10
12 regulation of isotype switching GO:0045191 8.96 IL4 IL10
13 cellular response to lipopolysaccharide GO:0071222 8.92 LY96 IL6 IL10 CXCL8

Molecular functions related to Acute Gonococcal Cervicitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 IL6 IL4 IL10
2 cytokine activity GO:0005125 8.92 IL6 IL4 IL10 CXCL8

Sources for Acute Gonococcal Cervicitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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