MCID: ACT012
MIFTS: 38

Acute Hemorrhagic Conjunctivitis

Categories: Eye diseases, Infectious diseases

Aliases & Classifications for Acute Hemorrhagic Conjunctivitis

MalaCards integrated aliases for Acute Hemorrhagic Conjunctivitis:

Name: Acute Hemorrhagic Conjunctivitis 12 15 17
Viral Conjunctivitis 12 17 71 32
Conjunctivitis, Acute Hemorrhagic 43 71
Epidemic Hemorrhagic Conjunctivitis 12
Apollo Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11227
ICD9CM 34 077.4
MeSH 43 D003232
NCIt 49 C34505
SNOMED-CT 67 31502007
ICD10 32 B30 B30.9
UMLS 71 C0009765 C0009774

Summaries for Acute Hemorrhagic Conjunctivitis

Disease Ontology : 12 A viral infectious disease that results in inflammation located in conjunctiva, has material basis in Human coxsackievirus A24 or has material basis in Human enterovirus 70, which are transmitted by contaminated fomites or transmitted by contact with contaminated hands. The infection has symptom vascular dilation, has symptom eyelid edema, has symptom photophobia, has symptom redness of the eyes, has symptom watering of the eye, has symptom conjunctival congestion, and has symptom superficial punctate epithelial keratitis.

MalaCards based summary : Acute Hemorrhagic Conjunctivitis, also known as viral conjunctivitis, is related to acute conjunctivitis and poliomyelitis. An important gene associated with Acute Hemorrhagic Conjunctivitis is ICAM1 (Intercellular Adhesion Molecule 1), and among its related pathways/superpathways are Transport to the Golgi and subsequent modification and Allograft rejection. The drugs Micronutrients and Trace Elements have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and thyroid.

Related Diseases for Acute Hemorrhagic Conjunctivitis

Diseases related to Acute Hemorrhagic Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 acute conjunctivitis 30.6 PSEN2 PLD3
2 poliomyelitis 30.3 ICAM1 EVC CD40LG
3 conjunctival folliculosis 30.1 PSEN2 PLD3
4 inclusion conjunctivitis 29.9 PLD3 CD40LG
5 shipyard eye 29.8 PSEN2 PLD3 MINK1
6 conjunctivitis 11.0
7 pharyngoconjunctival fever 10.3 PSEN2 PLD3
8 heterophyiasis 10.2 ICAM1 CD40LG
9 keratitis, hereditary 10.2
10 rapidly progressive glomerulonephritis 10.1 ICAM1 CD40LG
11 monkeypox 10.1 CD55 CD40LG
12 hantavirus hemorrhagic fever with renal syndrome 10.1 CD55 CD40LG
13 henoch-schoenlein purpura 10.1 ICAM1 CD40LG
14 immune-complex glomerulonephritis 10.1 ICAM1 CD40LG
15 amebiasis 10.0 ICAM1 CD40LG
16 lichen disease 10.0 ICAM1 CD40LG
17 proteasome-associated autoinflammatory syndrome 1 10.0
18 eye disease 10.0
19 keratoconjunctivitis 10.0
20 plasmodium falciparum malaria 10.0 ICAM1 CD55 CD40LG
21 myocarditis 10.0 ICAM1 CD55 CD40LG
22 meningitis 9.9 ICAM1 CD55 CD40LG
23 streptococcus pneumonia 9.9
24 chlamydia 9.9
25 alzheimer disease 19 9.9
26 anemia, autoimmune hemolytic 9.9 CD55 CD40LG
27 glomerulonephritis 9.9 ICAM1 CD55 CD40LG
28 lacrimal apparatus disease 9.9 ICAM1 CD40LG
29 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.9
30 bacterial infectious disease 9.9
31 punctate epithelial keratoconjunctivitis 9.9
32 bell's palsy 9.9
33 excessive tearing 9.9
34 facial paralysis 9.9
35 dermatitis 9.9
36 stomatitis 9.9
37 ophthalmia neonatorum 9.9
38 dysautonomia 9.9
39 dengue virus 9.8
40 suppression amblyopia 9.8
41 amblyopia 9.8
42 allergic conjunctivitis 9.8
43 trachoma 9.8
44 dengue disease 9.8
45 guillain-barre syndrome 9.8
46 filamentary keratitis 9.8
47 subacute thyroiditis 9.8
48 thyroiditis 9.8
49 muscular atrophy 9.8
50 chickenpox 9.8

Graphical network of the top 20 diseases related to Acute Hemorrhagic Conjunctivitis:



Diseases related to Acute Hemorrhagic Conjunctivitis

Symptoms & Phenotypes for Acute Hemorrhagic Conjunctivitis

Drugs & Therapeutics for Acute Hemorrhagic Conjunctivitis

Drugs for Acute Hemorrhagic Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Micronutrients Phase 4
2 Trace Elements Phase 4
3 Plasma Substitutes Phase 4
4 Nutrients Phase 4
5 Blood Substitutes Phase 4
6
Ketorolac Approved Phase 2, Phase 3 74103-06-3, 66635-83-4 3826
7
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
8
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
9 Anti-Inflammatory Agents Phase 2, Phase 3
10 Analgesics, Non-Narcotic Phase 2, Phase 3
11 Cathartics Phase 2, Phase 3
12 Gastrointestinal Agents Phase 2, Phase 3
13 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
14 Cyclooxygenase Inhibitors Phase 2, Phase 3
15 Laxatives Phase 2, Phase 3
16 Ketorolac Tromethamine Phase 2, Phase 3
17 Antirheumatic Agents Phase 2, Phase 3
18 Carboxymethylcellulose Sodium Phase 2, Phase 3
19 Analgesics Phase 2, Phase 3
20 Antiemetics Phase 3
21 HIV Protease Inhibitors Phase 3
22
protease inhibitors Phase 3
23 BB 1101 Phase 3
24 Hormone Antagonists Phase 3
25 Autonomic Agents Phase 3
26 Antineoplastic Agents, Hormonal Phase 3
27 glucocorticoids Phase 3
28 Hormones Phase 3
29
Ganciclovir Approved, Investigational 82410-32-0 3454
30
Iodine Approved, Investigational 7553-56-2 807
31
Povidone Approved 9003-39-8
32
Povidone-iodine Approved 25655-41-8
33 Antiviral Agents
34 Ganciclovir triphosphate
35 Lubricant Eye Drops
36 Ophthalmic Solutions
37 Pharmaceutical Solutions
38 Anti-Infective Agents
39 Anti-Infective Agents, Local
40 cadexomer iodine

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Treatment of Epidemic Keratoconjunctivitis With 2% Povidone-iodine Completed NCT01179412 Phase 4 2% povidone-iodine;2% povidone-iodine
2 Artificial Tears Versus Preservative Free Ketorolac Trometamol 0.45% for Treatment of Acute Viral Conjunctivitis Completed NCT01799863 Phase 2, Phase 3 Ketorolac trometamol 0.45% with carboxymethylcellulose;Preservative free artificial tear
3 A Randomized, Double-Masked Trial of Topical Dexamethasone 0.1%/Povidone-iodine 0.4% Versus Artificial Tears for Treatment of Viral Conjunctivitis Completed NCT01481519 Phase 3 dexamethasone 0.1%/povidone-iodine 0.4%;Artificial Tears
4 A Multi-Center, Randomized, Double-Masked Study to Evaluate the Clinical Efficacy and Safety of FST-100 Ophthalmic Suspension in the Treatment of Acute Viral Conjunctivitis Completed NCT01461954 Phase 2 FST-100;FST-100 Vehicle
5 Evaluation of the Therapeutic Efficacy of APD-209 Eye Drops in Treatment of Acute Phase Adenoviral-Induced Epidemic Keratoconjunctivitis (EKC). A Randomised, Double-Masked, Placebo-Controlled, Multi-Centre Proof-of-Concept Study Completed NCT01977443 Phase 2 APD-209 Eye drops;APD-209 Placebo Eye drops
6 Epidemiological, Prospective, Multicentric, Open Study To Assess The Characteristics And Frequency Of Adenoviral Conjunctivitis As Diagnosed With The Point Of Care AdenoPlus® Test In Patients Suffering From Acute Conjunctivitis Completed NCT03055065
7 Epidemiological, Prospective, Multicentric, Open Study To Assess The Characteristics And Frequency Of Adenoviral Conjunctivitis As Diagnosed With The Point Of Care AdenoPlus® Test In Patients Suffering From Acute Conjunctivitis Completed NCT02054273
8 Epidemiological, Prospective, Multicentric, Open Study To Assess The Characteristics And Frequency Of Adenoviral Conjunctivitis As Diagnosed With The Point Of Care AdenoPlus® Test In Patients Suffering From Acute Conjunctivitis Completed NCT02054234
9 Epidemiological, Prospective, Multicentric, Open Study To Assess The Characteristics And Frequency Of Adenoviral Conjunctivitis As Diagnosed With The Point Of Care AdenoPlus® Test In Patients Suffering From Acute Conjunctivitis Completed NCT02254330
10 Epidemiological, Prospective, Multicentric, Open Study To Assess The Characteristics And Frequency Of Adenoviral Conjunctivitis As Diagnosed With The Point Of Care AdenoPlus® Test In Patients Suffering From Acute Conjunctivitis Completed NCT02112773
11 Ganciclovir 0,15% Ophthalmic Gel in the Treatment of Adenovirus Keratoconjuntivitis Completed NCT01349452 Ganciclovir;Artificial tear
12 A Prospective Blinded Multi-center Clinical Trial to Evaluate the Efficacy of the Recently FDA Approved RPS Adeno Detector for Detecting Adenoviral Conjunctivitis Completed NCT00266734
13 A Comparison of the Sensitivity and Specificity of the RPS Adeno Detector IV™ at Detecting the Presence of Adenovirus to Viral Cell Culture. Completed NCT00921895
14 Avenova for the Treatment of Viral Conjunctivitis Recruiting NCT03861728
15 Reducing Adenoviral Patient Infected Days Recruiting NCT02472223 Betadine 5%;Artificial Tears

Search NIH Clinical Center for Acute Hemorrhagic Conjunctivitis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


emedastine
emedastine difumarate
Loteprednol
loteprednol etabonate

Cochrane evidence based reviews: conjunctivitis, acute hemorrhagic

Genetic Tests for Acute Hemorrhagic Conjunctivitis

Anatomical Context for Acute Hemorrhagic Conjunctivitis

MalaCards organs/tissues related to Acute Hemorrhagic Conjunctivitis:

40
Eye, Testes, Thyroid, Kidney, Endothelial, Colon, B Cells

Publications for Acute Hemorrhagic Conjunctivitis

Articles related to Acute Hemorrhagic Conjunctivitis:

(show top 50) (show all 361)
# Title Authors PMID Year
1
Forecast of the trend in incidence of acute hemorrhagic conjunctivitis in China from 2011-2019 using the Seasonal Autoregressive Integrated Moving Average (SARIMA) and Exponential Smoothing (ETS) models. 61
31953020 2020
2
Viral conjunctivitis: a retrospective study in an Australian hospital. 61
31300283 2019
3
Two cases of epidemic keratoconjunctivitis-associated dacryocystitis. 61
31852315 2019
4
Content validity of a novel patient-reported and observer-reported outcomes assessment to evaluate ocular symptoms associated with infectious conjunctivitis in both adult and pediatric populations. 61
31666074 2019
5
Pharmacist Compliance With Therapeutic Guidelines on Diagnosis and Treatment Provision. 61
31314116 2019
6
Re-emergence of a coxsackievirus A24 variant causing acute hemorrhagic conjunctivitis in Brazil from 2017 to 2018. 61
30725183 2019
7
Acute depigmentation of the iris: a retrospective analysis of 22 cases. 61
30851772 2019
8
The Epidemic Genotypes of Human Adenovirus in Outpatient Children with Adenoviral Conjunctivitis from 2011 to 2012 in Jiangxi, China. 61
31117098 2019
9
A randomized controlled trial of povidone-iodine/dexamethasone ophthalmic suspension for acute viral conjunctivitis. 61
30962674 2019
10
Epidemiology and molecular diagnosis of acute conjunctivitis in patients attending Hamadan, west Iran ophthalmology clinics 2016-2017. 61
31686938 2019
11
Outbreak of Epidemic Keratoconjunctivitis Caused by Human Adenovirus Type D53 in an Eye Care Clinic - Los Angeles County, 2017. 61
30521501 2018
12
Photo Rounds: Painful facial blisters, fever, and conjunctivitis. 61
30216398 2018
13
Aetiology of neonatal conjunctivitis evaluated in a population-based setting. 61
29345007 2018
14
Seasonal distribution of ocular conditions treated at the emergency room: a 1-year prospective study. 61
29846426 2018
15
The tear cytokine profile in patients with active Graves' orbitopathy. 61
29147850 2018
16
Conjunctival transcriptome profiling of Solomon Islanders with active trachoma in the absence of Chlamydia trachomatis infection. 61
29467021 2018
17
Investigational approach to adenoviral conjunctivitis: comparison of three diagnostic tests using a Bayesian latent class model. 61
31628833 2018
18
Different Clinical Presentations of the Same Epidemic Keratoconjunctivitis Outbreak in Premature Babies and Their Parents. 61
27598721 2018
19
Innate Immunity Evasion by Enteroviruses Linked to Epidemic Hand-Foot-Mouth Disease. 61
30349526 2018
20
Molecular epidemiology of circulating human adenovirus types in acute conjunctivitis cases in Chandigarh, North India. 61
29735838 2018
21
Utilization of Ophthalmology-Specific Emergency Department Services. 61
27599540 2018
22
Role of enhanced receptor engagement in the evolution of a pandemic acute hemorrhagic conjunctivitis virus. 61
29284752 2018
23
Sequelae from Epidemic Viral Conjunctivitis Can Be Associated with Inflammatory Trachoma in Schoolchildren? 61
27628039 2018
24
[Ophthalmological symptoms of measles and their treatment]. 61
28942662 2017
25
Symptomatic Treatment of Subepithelial Infiltrates after Viral Conjunctivitis: Loteprednol or Dexamethasone? 61
27015587 2017
26
Crystalline lens dislocation secondary to bacterial endogenous endophthalmitis. 61
29260103 2017
27
Molecular identification of viral agents associated with acute conjunctivitis: a prospective controlled study. 61
28535396 2017
28
Infectious Diseases and Tropical Cyclones in Southeast China. 61
28481286 2017
29
[Senegalese experience with acute viral conjunctivitis]. 61
28342559 2017
30
Α molecular epidemiological analysis of adenoviruses from excess conjunctivitis cases. 61
28438142 2017
31
Molecular epidemiology of acute hemorrhagic conjunctivitis caused by coxsackie A type 24 variant in China, 2004-2014. 61
28332617 2017
32
Anti-Interleukin-6 Receptor Tocilizumab for Severe Juvenile Idiopathic Arthritis-Associated Uveitis Refractory to Anti-Tumor Necrosis Factor Therapy: A Multicenter Study of Twenty-Five Patients. 61
27696756 2017
33
Paediatric Virology: A rapidly increasing educational challenge. 61
28352303 2017
34
[The virological and epidemiological aspects of human adenoviral conjunctivitis in Tunisia]. 61
28063620 2017
35
Posterior scleritis presenting as conjunctivitis in a child. 61
27941114 2016
36
Effect of "Pink Eye" Label on Parents' Intent to Use Antibiotics and Perceived Contagiousness. 61
26294761 2016
37
Dengue Fever Presenting Atypically with Viral Conjunctivitis and Subacute Thyroiditis. 61
27376214 2016
38
Complete genome analysis of coxsackievirus A24 isolated in Yunnan, China, in 2013. 61
26935916 2016
39
A Polymerase Chain Reaction-Based Algorithm to Detect and Prevent Transmission of Adenoviral Conjunctivitis in Hospital Employees. 61
26694258 2016
40
Allosteric inhibitors of Coxsackie virus A24 RNA polymerase. 61
26762834 2016
41
Acute hemorrhagic conjunctivitis epidemic in São Paulo State, Brazil, 2011. 61
27754516 2016
42
Phylodynamic Characterization of an Ocular-Tropism Coxsackievirus A24 Variant. 61
27529556 2016
43
Acute bacterial conjunctivitis - antibiotic susceptibility and resistance to commercially available topical antibiotics in Nepal. 61
28242882 2016
44
The prevalence of adenoviral conjunctivitis at the Clinical Hospital of the State University of Campinas, Brazil. 61
26602522 2015
45
Adenoviral keratoconjunctivitis. 61
26077630 2015
46
Dexamethasone/Povidone Eye Drops versus Artificial Tears for Treatment of Presumed Viral Conjunctivitis: A Randomized Clinical Trial. 61
25310347 2015
47
[Molecular Identification and Phylogenetic Analyses of Coxsackievirus A24v Causing an Outbreak of Acute Hemorrhagic Conjunctivitis in Jiangxi, China, in 2010]. 61
26470530 2015
48
Psychogenic unilateral pseudoptosis. 61
24608330 2015
49
An outbreak of viral conjunctivitis in an Irish military deployment to Liberia. 61
25736947 2015
50
A 5-year study of adenoviruses causing conjunctivitis in Izmir, Turkey. 61
25196311 2015

Variations for Acute Hemorrhagic Conjunctivitis

Expression for Acute Hemorrhagic Conjunctivitis

Search GEO for disease gene expression data for Acute Hemorrhagic Conjunctivitis.

Pathways for Acute Hemorrhagic Conjunctivitis

Pathways related to Acute Hemorrhagic Conjunctivitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.44 ST8SIA6 ST8SIA5 ST8SIA3 ST6GALNAC3 CD55
2
Show member pathways
12.3 IFNA7 ICAM1 CD55 CD40LG
3
Show member pathways
11.55 ST8SIA6 ST8SIA5 ST8SIA3 ST6GALNAC3
4
Show member pathways
10.25 ST8SIA5 ST8SIA3 ST6GALNAC3

GO Terms for Acute Hemorrhagic Conjunctivitis

Cellular components related to Acute Hemorrhagic Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.96 WLS ST8SIA6 ST8SIA5 ST8SIA3 ST6GALNAC3 PSEN2
2 membrane GO:0016020 9.93 WLS ST8SIA6 ST8SIA5 ST8SIA3 ST6GALNAC3 PSEN2
3 Golgi apparatus GO:0005794 9.5 WLS ST8SIA6 ST8SIA5 ST8SIA3 ST6GALNAC3 PSEN2
4 Golgi membrane GO:0000139 9.17 WLS ST8SIA6 ST8SIA5 ST8SIA3 ST6GALNAC3 PSEN2

Biological processes related to Acute Hemorrhagic Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein glycosylation GO:0006486 9.56 ST8SIA6 ST8SIA5 ST8SIA3 ST6GALNAC3
2 B cell proliferation GO:0042100 9.43 IFNA7 CD40LG
3 leukocyte cell-cell adhesion GO:0007159 9.4 ICAM1 CD40LG
4 oligosaccharide metabolic process GO:0009311 9.37 ST8SIA6 ST8SIA3
5 glycoprotein metabolic process GO:0009100 9.33 ST8SIA6 ST8SIA3 ST6GALNAC3
6 glycosphingolipid biosynthetic process GO:0006688 9.32 ST8SIA5 ST8SIA3
7 ganglioside biosynthetic process GO:0001574 9.13 ST8SIA6 ST8SIA3 ST6GALNAC3
8 sialylation GO:0097503 8.92 ST8SIA6 ST8SIA5 ST8SIA3 ST6GALNAC3

Molecular functions related to Acute Hemorrhagic Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transferase activity, transferring glycosyl groups GO:0016757 9.46 ST8SIA6 ST8SIA5 ST8SIA3 ST6GALNAC3
2 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity GO:0003828 8.96 ST8SIA5 ST8SIA3
3 sialyltransferase activity GO:0008373 8.92 ST8SIA6 ST8SIA5 ST8SIA3 ST6GALNAC3

Sources for Acute Hemorrhagic Conjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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