MCID: ACT012
MIFTS: 42

Acute Hemorrhagic Conjunctivitis

Categories: Eye diseases, Infectious diseases

Aliases & Classifications for Acute Hemorrhagic Conjunctivitis

MalaCards integrated aliases for Acute Hemorrhagic Conjunctivitis:

Name: Acute Hemorrhagic Conjunctivitis 12 15 17
Viral Conjunctivitis 12 17 74
Conjunctivitis, Acute Hemorrhagic 45 74
Epidemic Hemorrhagic Conjunctivitis 12
Apollo Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11227
ICD9CM 36 077.4
MeSH 45 D003232
NCIt 51 C34505
SNOMED-CT 69 31502007
ICD10 34 B30

Summaries for Acute Hemorrhagic Conjunctivitis

Disease Ontology : 12 A viral infectious disease that results in inflammation located in conjunctiva, has material basis in Human coxsackievirus A24 or has material basis in Human enterovirus 70, which are transmitted by contaminated fomites or transmitted by contact with contaminated hands. The infection has symptom vascular dilation, has symptom eyelid edema, has symptom photophobia, has symptom redness of the eyes, has symptom watering of the eye, has symptom conjunctival congestion, and has symptom superficial punctate epithelial keratitis.

MalaCards based summary : Acute Hemorrhagic Conjunctivitis, also known as viral conjunctivitis, is related to acute conjunctivitis and shipyard eye. An important gene associated with Acute Hemorrhagic Conjunctivitis is ICAM1 (Intercellular Adhesion Molecule 1), and among its related pathways/superpathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. The drugs Iodine and Povidone have been mentioned in the context of this disorder. Affiliated tissues include eye, thyroid and testes, and related phenotypes are hematopoietic system and immune system

Related Diseases for Acute Hemorrhagic Conjunctivitis

Diseases related to Acute Hemorrhagic Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
# Related Disease Score Top Affiliating Genes
1 acute conjunctivitis 29.9 PLD3 PSEN2
2 shipyard eye 29.8 PLD3 PSEN2
3 conjunctivitis 10.9
4 viral infectious disease 10.4
5 alternating hemiplegia of childhood 10.3
6 acute contagious conjunctivitis 10.3
7 conjunctivitis with pseudomembrane 10.3
8 inclusion conjunctivitis 10.0 PLD3 PSEN2
9 conjunctival disease 10.0 PLD3 PSEN2
10 plasmodium falciparum malaria 9.9 CD55 ICAM1
11 dermatitis 9.8
12 keratoconjunctivitis 9.8
13 dysautonomia 9.8
14 myocarditis 9.8 CD55 ICAM1
15 keratitis, hereditary 9.8
16 dengue virus 9.8
17 dengue disease 9.8
18 trachoma 9.8
19 subacute thyroiditis 9.8
20 thyroiditis 9.8
21 vernal keratoconjunctivitis 9.8

Graphical network of the top 20 diseases related to Acute Hemorrhagic Conjunctivitis:



Diseases related to Acute Hemorrhagic Conjunctivitis

Symptoms & Phenotypes for Acute Hemorrhagic Conjunctivitis

MGI Mouse Phenotypes related to Acute Hemorrhagic Conjunctivitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 CD55 ICAM1 PLD3 PSEN2 ST3GAL6 ST8SIA1
2 immune system MP:0005387 8.92 ICAM1 PSEN2 ST3GAL6 ST8SIA1

Drugs & Therapeutics for Acute Hemorrhagic Conjunctivitis

Drugs for Acute Hemorrhagic Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational Phase 4,Phase 3 7553-56-2 807
2
Povidone Approved Phase 4,Phase 3 9003-39-8
3
Povidone-iodine Approved Phase 4,Phase 3 25655-41-8
4 cadexomer iodine Phase 4,Phase 3
5 Anti-Infective Agents Phase 4,Phase 3,Not Applicable
6 Nutrients Phase 4,Phase 3
7 Micronutrients Phase 4,Phase 3
8 Anti-Infective Agents, Local Phase 4,Phase 3
9 Plasma Substitutes Phase 4,Phase 3
10 Blood Substitutes Phase 4,Phase 3
11 Trace Elements Phase 4,Phase 3
12
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
13
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
14
Ketorolac Approved Phase 2, Phase 3 74103-06-3, 66635-83-4 3826
15 Ophthalmic Solutions Phase 3,Phase 2,Not Applicable
16 Lubricant Eye Drops Phase 3,Phase 2,Not Applicable
17 Pharmaceutical Solutions Phase 3,Phase 2,Not Applicable
18 Hormones Phase 3
19 Anti-Inflammatory Agents Phase 3,Phase 2
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
21 Antiemetics Phase 3
22 Peripheral Nervous System Agents Phase 3,Phase 2
23 Autonomic Agents Phase 3
24 glucocorticoids Phase 3
25 Gastrointestinal Agents Phase 3,Phase 2
26 Antineoplastic Agents, Hormonal Phase 3
27 Hormone Antagonists Phase 3
28 BB 1101 Phase 3
29
protease inhibitors Phase 3
30 HIV Protease Inhibitors Phase 3
31 Laxatives Phase 2, Phase 3
32 Cyclooxygenase Inhibitors Phase 2, Phase 3
33 Antirheumatic Agents Phase 2, Phase 3
34 Cathartics Phase 2, Phase 3
35 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
36 Analgesics Phase 2, Phase 3
37 Carboxymethylcellulose Sodium Phase 2, Phase 3
38 Ketorolac Tromethamine Phase 2, Phase 3
39 Analgesics, Non-Narcotic Phase 2, Phase 3
40
Ganciclovir Approved, Investigational Not Applicable 82410-32-0 3454
41 Antiviral Agents Not Applicable
42 Nucleic Acid Synthesis Inhibitors Not Applicable
43 Ganciclovir triphosphate Not Applicable

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Treatment of Epidemic Keratoconjunctivitis With 2% Povidone-iodine Completed NCT01179412 Phase 4 2% povidone-iodine;2% povidone-iodine
2 A Trial of Topical Dexamethasone Versus Artificial Tears for Treatment of Viral Conjunctivitis Completed NCT01481519 Phase 3 dexamethasone 0.1%/povidone-iodine 0.4%;Artificial Tears
3 Artificial Tears Versus Preservative Free Ketorolac Trometamol 0.45% for Acute Viral Conjunctivitis Completed NCT01799863 Phase 2, Phase 3 Ketorolac trometamol 0.45% with carboxymethylcellulose;Preservative free artificial tear
4 FST-100 in the Treatment of Acute Viral Conjunctivitis Completed NCT01461954 Phase 2 FST-100;FST-100 Vehicle
5 Therapeutic Efficacy of APD-209 Eye Drops in Treatment of Epidemic Keratoconjunctivitis (EKC) Completed NCT01977443 Phase 2 APD-209 Eye drops;APD-209 Placebo Eye drops
6 Trial to Evaluate the Efficacy and Safety of IVIEW-1201 in Acute Viral Conjunctivitis Not yet recruiting NCT03749317 Phase 2 IVIEW-1201;Placebo
7 ADenoVirus Initiative Study in Epidemiology in Italy Completed NCT03055065
8 ADenoVirus Initiative Study in Epidemiology in Spain Completed NCT02254330
9 ADenoVirus Initiative Study in Epidemiology in UK Completed NCT02112773
10 ADenoVirus Initiative Study in Epidemiology in Germany Completed NCT02054273
11 ADenoVirus Initiative Study in Epidemiology in France Completed NCT02054234
12 Evaluation of a Rapid Screening Test for Detection of Adenovirus in Tears Completed NCT00266734 Not Applicable
13 A Comparison of the RPS Adeno Detector IV to Viral Cell Culture at Detecting Adenoviral Conjunctivitis Completed NCT00921895 Not Applicable
14 Ganciclovir 0,15% Ophthalmic Gel in the Treatment of Adenovirus Keratoconjuntivitis Completed NCT01349452 Not Applicable Ganciclovir;Artificial tear
15 Viral Conjunctivitis Treatment Study Recruiting NCT03861728 Not Applicable

Search NIH Clinical Center for Acute Hemorrhagic Conjunctivitis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: conjunctivitis, acute hemorrhagic

Genetic Tests for Acute Hemorrhagic Conjunctivitis

Anatomical Context for Acute Hemorrhagic Conjunctivitis

MalaCards organs/tissues related to Acute Hemorrhagic Conjunctivitis:

42
Eye, Thyroid, Testes, Kidney, Colon, Endothelial

Publications for Acute Hemorrhagic Conjunctivitis

Articles related to Acute Hemorrhagic Conjunctivitis:

(show top 50) (show all 156)
# Title Authors Year
1
A randomized controlled trial of povidone-iodine/dexamethasone ophthalmic suspension for acute viral conjunctivitis. ( 30962674 )
2019
2
Re-emergence of a coxsackievirus A24 variant causing acute hemorrhagic conjunctivitis in Brazil from 2017 to 2018. ( 30725183 )
2019
3
Sequelae from Epidemic Viral Conjunctivitis Can Be Associated with Inflammatory Trachoma in Schoolchildren? ( 27628039 )
2018
4
Role of enhanced receptor engagement in the evolution of a pandemic acute hemorrhagic conjunctivitis virus. ( 29284752 )
2018
5
Symptomatic Treatment of Subepithelial Infiltrates after Viral Conjunctivitis: Loteprednol or Dexamethasone? ( 27015587 )
2017
6
Molecular epidemiology of acute hemorrhagic conjunctivitis caused by coxsackie A type 24 variant in China, 2004-2014. ( 28332617 )
2017
7
Dengue Fever Presenting Atypically with Viral Conjunctivitis and Subacute Thyroiditis. ( 27376214 )
2016
8
Acute hemorrhagic conjunctivitis epidemic in São Paulo State, Brazil, 2011. ( 27754516 )
2016
9
An outbreak of viral conjunctivitis in an Irish military deployment to Liberia. ( 25736947 )
2015
10
Dexamethasone/Povidone Eye Drops versus Artificial Tears for Treatment of Presumed Viral Conjunctivitis: A Randomized Clinical Trial. ( 25310347 )
2015
11
Acute hemorrhagic conjunctivitis: anti-coxsackievirus A24 variant secretory immunoglobulin A in acute and convalescent tear. ( 26392747 )
2015
12
Virological and epidemiological analysis of coxsackievirus A24 variant epidemic of acute hemorrhagic conjunctivitis in Okinawa, Japan, in 2011. ( 26109843 )
2015
13
Appropriate prescribing for viral conjunctivitis. ( 25551873 )
2014
14
Artificial tears alone versus 0.45% ketorolac tromethamine with artificial tears for the treatment of acute viral conjunctivitis. ( 25076474 )
2014
15
Molecular evolution of VP3, VP1, 3C(pro) and 3D(pol) coding regions in coxsackievirus group A type 24 variant isolates from acute hemorrhagic conjunctivitis in 2011 in Okinawa, Japan. ( 24517637 )
2014
16
Genetic characteristics of the coxsackievirus A24 variant causing outbreaks of acute hemorrhagic conjunctivitis in Jiangsu, China, 2010. ( 24475191 )
2014
17
A molecular investigative approach to an outbreak of acute hemorrhagic conjunctivitis in Egypt, October 2010. ( 23531270 )
2013
18
Molecular identification and phylogenetic study of coxsackievirus A24 variant isolated from an outbreak of acute hemorrhagic conjunctivitis in India in 2010. ( 23124888 )
2013
19
A randomised placebo-controlled trial of topical steroid in presumed viral conjunctivitis. ( 22053100 )
2012
20
Phylogenetic and molecular characterization of coxsackievirus A24 variant isolates from a 2010 acute hemorrhagic conjunctivitis outbreak in Guangdong, China. ( 22336176 )
2012
21
A randomised placebo-controlled trial of topical steroid in presumed viral conjunctivitis. ( 21252084 )
2011
22
Treatment of viral conjunctivitis with antiviral drugs. ( 21319870 )
2011
23
Molecular characterization and phylogenetic study of coxsackievirus A24v causing outbreaks of acute hemorrhagic conjunctivitis (AHC) in Brazil. ( 21858030 )
2011
24
An antiviral small-interfering RNA simultaneously effective against the most prevalent enteroviruses causing acute hemorrhagic conjunctivitis. ( 20739472 )
2011
25
Understanding of acute hemorrhagic conjunctivitis (AHC) epidemics and outbreaks of Paederus spp keratoconjuctivitis, periorbital oedema ("Nairobi red eyes") and dermatitis. ( 21516962 )
2010
26
Notes from the field: acute hemorrhagic conjunctivitis outbreaks caused by coxsackievirus A24v --- Uganda and southern Sudan, 2010. ( 20724969 )
2010
27
Outbreak of acute hemorrhagic conjunctivitis in Yunnan, People's Republic of China, 2007. ( 20579343 )
2010
28
[Outbreak of acute hemorrhagic conjunctivitis in Beijing City in 2007 caused by coxsackievirus A24 variant: molecular identification and phylogenetic analysis]. ( 19769156 )
2009
29
Magnetotherapy in the treatment of viral conjunctivitis and keratitis. ( 19323071 )
2008
30
Corneal superinfection in acute viral conjunctivitis in young children. ( 19043952 )
2008
31
Delayed epithelial ingrowth caused by viral conjunctivitis after LASIK. ( 18729311 )
2008
32
Multiple outbreaks of acute hemorrhagic conjunctivitis due to a variant of coxsackievirus A24: Guangdong, China, 2007. ( 18712817 )
2008
33
An outbreak of acute hemorrhagic conjunctivitis (AHC) caused by coxsackievirus A24 variant in Pakistan. ( 18638510 )
2008
34
Molecular identification of coxsackievirus A24 variant, isolated from an outbreak of acute hemorrhagic conjunctivitis in Singapore in 2005. ( 17680326 )
2007
35
Outbreak of acute hemorrhagic conjunctivitis in Maharashtra and Gujarat states of India, caused by Coxsackie virus A-24 variant. ( 17457917 )
2007
36
Rapid diagnosis of acute hemorrhagic conjunctivitis due to coxsackievirus A24 variant by real-time one-step RT-PCR. ( 17328967 )
2007
37
Two outbreaks of acute hemorrhagic conjunctivitis in Africa due to genotype III coxsackievirus A24 variant. ( 17294159 )
2007
38
Allergy and infections: long-term improvement of vernal keratoconjunctivitis following viral conjunctivitis. ( 16761253 )
2006
39
Viral conjunctivitis interfering with the clinical activity score and management of thyroid ophthalmopathy. ( 16527772 )
2006
40
Viral investigation of acute hemorrhagic conjunctivitis outbreak (2003) in Nepal using molecular methods. ( 17333732 )
2006
41
Acute hemorrhagic conjunctivitis and coxsackievirus A24v, Rio de Janeiro, Brazil, 2004. ( 16704792 )
2006
42
Acute hemorrhagic conjunctivitis epidemic caused by coxsackievirus A24 variants in Korea during 2002-2003. ( 16299722 )
2006
43
Rapid identification of the coxsackievirus A24 variant by molecular serotyping in an outbreak of acute hemorrhagic conjunctivitis. ( 15750062 )
2005
44
Outbreak of acute hemorrhagic conjunctivitis in French Guiana and West Indies caused by coxsackievirus A24 variant: phylogenetic analysis reveals Asian import. ( 15714481 )
2005
45
Epidemiologic investigation into the outbreak of acute hemorrhagic conjunctivitis in gyeongju-city, South Korea, in 2002. ( 25175612 )
2004
46
Acute hemorrhagic conjunctivitis outbreak caused by Coxsackievirus A24--Puerto Rico, 2003. ( 15269699 )
2004
47
Towards an in vitro model for acute hemorrhagic conjunctivitis: cytokine-mediated vascular endothelial cell activation triggered by enterovirus type 70 infection. ( 15072749 )
2004
48
The change of etiological agents and clinical signs of epidemic viral conjunctivitis over an 18-year period in southern Taiwan. ( 12768288 )
2003
49
Treatment of viral conjunctivitis in children. ( 12751650 )
2003
50
Acute hemorrhagic conjunctivitis epidemic--2003 in Nepal. ( 15024766 )
2003

Variations for Acute Hemorrhagic Conjunctivitis

Expression for Acute Hemorrhagic Conjunctivitis

Search GEO for disease gene expression data for Acute Hemorrhagic Conjunctivitis.

Pathways for Acute Hemorrhagic Conjunctivitis

Pathways related to Acute Hemorrhagic Conjunctivitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.19 CD55 ST3GAL6 ST6GAL2 ST6GALNAC5 ST8SIA1
2
Show member pathways
12.44 CD55 ST3GAL6 ST6GAL2 ST6GALNAC5 ST8SIA1
3
Show member pathways
11.55 ST3GAL6 ST6GAL2 ST6GALNAC5 ST8SIA1
4
Show member pathways
10.77 ST6GALNAC5 ST8SIA1
5 10.69 ST3GAL6 ST8SIA1
6
Show member pathways
10.37 ST6GAL2 ST6GALNAC5 ST8SIA1

GO Terms for Acute Hemorrhagic Conjunctivitis

Cellular components related to Acute Hemorrhagic Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.8 ICAM1 PLD3 PSEN2 ST3GAL6 ST6GAL2 ST6GALNAC5
2 membrane GO:0016020 9.76 CD55 ICAM1 PLD3 PSEN2 ST3GAL6 ST6GAL2
3 Golgi apparatus GO:0005794 9.35 PSEN2 ST3GAL6 ST6GAL2 ST6GALNAC5 ST8SIA1
4 Golgi membrane GO:0000139 9.1 CD55 PSEN2 ST3GAL6 ST6GAL2 ST6GALNAC5 ST8SIA1

Biological processes related to Acute Hemorrhagic Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral entry into host cell GO:0046718 9.37 CD55 ICAM1
2 cellular response to interleukin-6 GO:0071354 9.32 ICAM1 ST3GAL6
3 oligosaccharide metabolic process GO:0009311 9.26 ST3GAL6 ST6GAL2
4 protein glycosylation GO:0006486 9.26 ST3GAL6 ST6GAL2 ST6GALNAC5 ST8SIA1
5 glycosphingolipid biosynthetic process GO:0006688 9.16 ST6GALNAC5 ST8SIA1
6 sialylation GO:0097503 8.92 ST3GAL6 ST6GAL2 ST6GALNAC5 ST8SIA1

Molecular functions related to Acute Hemorrhagic Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transferase activity, transferring glycosyl groups GO:0016757 9.26 ST3GAL6 ST6GAL2 ST6GALNAC5 ST8SIA1
2 virus receptor activity GO:0001618 9.16 CD55 ICAM1
3 sialyltransferase activity GO:0008373 8.92 ST3GAL6 ST6GAL2 ST6GALNAC5 ST8SIA1

Sources for Acute Hemorrhagic Conjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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