MCID: ACT012
MIFTS: 33

Acute Hemorrhagic Conjunctivitis

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Acute Hemorrhagic Conjunctivitis

MalaCards integrated aliases for Acute Hemorrhagic Conjunctivitis:

Name: Acute Hemorrhagic Conjunctivitis 12 15 17
Viral Conjunctivitis 12 17 70 32
Conjunctivitis, Acute Hemorrhagic 44 70
Epidemic Hemorrhagic Conjunctivitis 12
Apollo Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11227
ICD9CM 34 077.4
MeSH 44 D003232
NCIt 50 C34505
SNOMED-CT 67 186677009
ICD10 32 B30 B30.9
UMLS 70 C0009765 C0009774

Summaries for Acute Hemorrhagic Conjunctivitis

Disease Ontology : 12 A viral infectious disease that results in inflammation located in conjunctiva, has material basis in Human coxsackievirus A24 or has material basis in Human enterovirus 70, which are transmitted by contaminated fomites or transmitted by contact with contaminated hands. The infection has symptom vascular dilation, has symptom eyelid edema, has symptom photophobia, has symptom redness of the eyes, has symptom watering of the eye, has symptom conjunctival congestion, and has symptom superficial punctate epithelial keratitis.

MalaCards based summary : Acute Hemorrhagic Conjunctivitis, also known as viral conjunctivitis, is related to poliomyelitis and shipyard eye. An important gene associated with Acute Hemorrhagic Conjunctivitis is ICAM1 (Intercellular Adhesion Molecule 1). The drugs Povidone and Povidone-iodine have been mentioned in the context of this disorder. Affiliated tissues include eye, kidney and endothelial.

Related Diseases for Acute Hemorrhagic Conjunctivitis

Diseases related to Acute Hemorrhagic Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
# Related Disease Score Top Affiliating Genes
1 poliomyelitis 30.1 SCARB2 ICAM1
2 shipyard eye 30.0 PSEN2 MINK1
3 conjunctival folliculosis 29.7 PSEN2 MINK1
4 conjunctivitis 11.1
5 keratitis, hereditary 10.3
6 acute conjunctivitis 10.3
7 eye disease 10.2
8 proteasome-associated autoinflammatory syndrome 1 10.1
9 keratoconjunctivitis 10.1
10 streptococcus pneumonia 10.0
11 chlamydia 10.0
12 alzheimer disease 19 10.0
13 ifap syndrome 2 10.0
14 bacterial infectious disease 10.0
15 bell's palsy 10.0
16 excessive tearing 10.0
17 facial paralysis 10.0
18 dermatitis 10.0
19 stomatitis 10.0
20 ophthalmia neonatorum 10.0
21 cytokine deficiency 10.0
22 dysautonomia 10.0
23 midface dysplasia 9.9 BPIFB6 BPIFB3
24 dengue virus 9.9
25 suppression amblyopia 9.9
26 amblyopia 9.9
27 allergic conjunctivitis 9.9
28 trachoma 9.9
29 allergic disease 9.9
30 dengue disease 9.9
31 guillain-barre syndrome 9.9
32 inclusion conjunctivitis 9.9
33 filamentary keratitis 9.9
34 subacute thyroiditis 9.9
35 thyroiditis 9.9
36 muscular atrophy 9.9
37 chickenpox 9.9
38 molluscum contagiosum 9.9
39 bacterial conjunctivitis 9.9
40 vernal keratoconjunctivitis 9.9

Graphical network of the top 20 diseases related to Acute Hemorrhagic Conjunctivitis:



Diseases related to Acute Hemorrhagic Conjunctivitis

Symptoms & Phenotypes for Acute Hemorrhagic Conjunctivitis

Drugs & Therapeutics for Acute Hemorrhagic Conjunctivitis

Drugs for Acute Hemorrhagic Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Povidone Approved Phase 4 9003-39-8 131751496
2
Povidone-iodine Approved Phase 4 25655-41-8
3
Iodine Approved, Investigational Phase 4 7553-56-2 807
4
Cadexomer iodine Experimental Phase 4 94820-09-4
5 Anti-Infective Agents, Local Phase 4
6 Anti-Infective Agents Phase 4
7 Plasma Substitutes Phase 4
8 Blood Substitutes Phase 4
9 Trace Elements Phase 4
10 Nutrients Phase 4
11 Micronutrients Phase 4
12
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
13
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
14
Ketorolac Approved Phase 2, Phase 3 74103-06-3, 66635-83-4 3826
15 Gastrointestinal Agents Phase 3
16 Pharmaceutical Solutions Phase 3
17 Hormone Antagonists Phase 3
18 Ophthalmic Solutions Phase 3
19 Antineoplastic Agents, Hormonal Phase 3
20 Anti-Inflammatory Agents Phase 3
21 Hormones Phase 3
22
protease inhibitors Phase 3
23 Antiemetics Phase 3
24 glucocorticoids Phase 3
25 Lubricant Eye Drops Phase 3
26 BB 1101 Phase 3
27 HIV Protease Inhibitors Phase 3
28 Analgesics, Non-Narcotic Phase 2, Phase 3
29 Analgesics Phase 2, Phase 3
30 Cathartics Phase 2, Phase 3
31 Antirheumatic Agents Phase 2, Phase 3
32 Cyclooxygenase Inhibitors Phase 2, Phase 3
33 Ketorolac Tromethamine Phase 2, Phase 3
34 Laxatives Phase 2, Phase 3
35 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
36 Carboxymethylcellulose Sodium Phase 2, Phase 3

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Treatment of Epidemic Keratoconjunctivitis With 2% Povidone-iodine Completed NCT01179412 Phase 4 2% povidone-iodine;2% povidone-iodine
2 A Randomized, Double-Masked Trial of Topical Dexamethasone 0.1%/Povidone-iodine 0.4% Versus Artificial Tears for Treatment of Viral Conjunctivitis Completed NCT01481519 Phase 3 dexamethasone 0.1%/povidone-iodine 0.4%;Artificial Tears
3 Artificial Tears Versus Preservative Free Ketorolac Trometamol 0.45% for Treatment of Acute Viral Conjunctivitis Completed NCT01799863 Phase 2, Phase 3 Ketorolac trometamol 0.45% with carboxymethylcellulose;Preservative free artificial tear
4 A Multi-Center, Randomized, Double-Masked Study to Evaluate the Clinical Efficacy and Safety of FST-100 Ophthalmic Suspension in the Treatment of Acute Viral Conjunctivitis Completed NCT01461954 Phase 2 FST-100;FST-100 Vehicle
5 Evaluation of the Therapeutic Efficacy of APD-209 Eye Drops in Treatment of Acute Phase Adenoviral-Induced Epidemic Keratoconjunctivitis (EKC). A Randomised, Double-Masked, Placebo-Controlled, Multi-Centre Proof-of-Concept Study Completed NCT01977443 Phase 2 APD-209 Eye drops;APD-209 Placebo Eye drops
6 Epidemiological, Prospective, Multicentric, Open Study To Assess The Characteristics And Frequency Of Adenoviral Conjunctivitis As Diagnosed With The Point Of Care AdenoPlus® Test In Patients Suffering From Acute Conjunctivitis Completed NCT03055065
7 Epidemiological, Prospective, Multicentric, Open Study To Assess The Characteristics And Frequency Of Adenoviral Conjunctivitis As Diagnosed With The Point Of Care AdenoPlus® Test In Patients Suffering From Acute Conjunctivitis Completed NCT02254330
8 Epidemiological, Prospective, Multicentric, Open Study To Assess The Characteristics And Frequency Of Adenoviral Conjunctivitis As Diagnosed With The Point Of Care AdenoPlus® Test In Patients Suffering From Acute Conjunctivitis Completed NCT02112773
9 Epidemiological, Prospective, Multicentric, Open Study To Assess The Characteristics And Frequency Of Adenoviral Conjunctivitis As Diagnosed With The Point Of Care AdenoPlus® Test In Patients Suffering From Acute Conjunctivitis Completed NCT02054273
10 Epidemiological, Prospective, Multicentric, Open Study To Assess The Characteristics And Frequency Of Adenoviral Conjunctivitis As Diagnosed With The Point Of Care AdenoPlus® Test In Patients Suffering From Acute Conjunctivitis Completed NCT02054234
11 Prevalence of SARS-CoV-2 in Conjunctival Swab Samples Among Patients Presenting With Conjunctivitis to the Ophthalmology Clinics During the COVID-19 Pandemic Recruiting NCT04374656
12 Avenova for the Treatment of Viral Conjunctivitis Recruiting NCT03861728

Search NIH Clinical Center for Acute Hemorrhagic Conjunctivitis

Inferred drug relations via UMLS 70 / NDF-RT 51 :


emedastine
emedastine difumarate
Loteprednol
loteprednol etabonate

Cochrane evidence based reviews: conjunctivitis, acute hemorrhagic

Genetic Tests for Acute Hemorrhagic Conjunctivitis

Anatomical Context for Acute Hemorrhagic Conjunctivitis

MalaCards organs/tissues related to Acute Hemorrhagic Conjunctivitis:

40
Eye, Kidney, Endothelial, Colon, Thyroid

Publications for Acute Hemorrhagic Conjunctivitis

Articles related to Acute Hemorrhagic Conjunctivitis:

(show top 50) (show all 393)
# Title Authors PMID Year
1
A "shining" example of interstitial keratitis. 61
33437893 2021
2
Ophthalmic manifestations in the COVID-19 clinical spectrum. 61
33595502 2021
3
Detection of Coronavirus in Tear Samples of Hospitalized Patients With Confirmed SARS-CoV-2 From Oropharyngeal Swabs. 61
32897895 2021
4
Molecular Characterization of Coxsackievirus A24v from Feces and Conjunctiva Reveals Epidemiological Links. 61
33807540 2021
5
Chlamydia trachomatis Mimicking COVID-19 Chronic Follicular Conjunctivitis. 61
33604091 2021
6
Ocular manifestations of SARS-CoV-2: Literature review. 61
32873480 2021
7
Granulomatosis with polyangiitis-associated ischemic optic neuropathy in a previously healthy 50-year-old female. 61
32995666 2020
8
The role of ozonized oil and a combination of tobramycin/dexamethasone eye drops in the treatment of viral conjunctivitis: a randomized clinical trial. 61
32696102 2020
9
Two cases of epidemic keratoconjunctivitis-associated dacryocystitis. 61
31852315 2020
10
Conjunctivitis in COVID-19 patients: frequency and clinical presentation. 61
32860573 2020
11
Acute Onset of Bilateral Follicular Conjunctivitis in two Patients with Confirmed SARS-CoV-2 Infections. 61
33021847 2020
12
Natural protection of ocular surface from viral infections - A hypothesis. 61
32679424 2020
13
Pentavalent Sialic Acid Conjugates Block Coxsackievirus A24 Variant and Human Adenovirus Type 37-Viruses That Cause Highly Contagious Eye Infections. 61
32845119 2020
14
Management of conjunctivitis and other causes of red eye during the COVID-19 pandemic. 61
33015681 2020
15
Epidemiology of pseudomembranous conjunctivitis in a tertiary hospital: A 2-year retrospective study. 61
32907398 2020
16
Molecular evolution of coxsackievirus A24v in Cuba over 23-years, 1986-2009. 61
32792520 2020
17
Intracorneal hemorrhage secondary to acute viral conjunctivitis. 61
32807547 2020
18
Ocular manifestations and viral shedding in tears of pediatric patients with coronavirus disease 2019: a preliminary report. 61
32531341 2020
19
Relapsing viral keratoconjunctivitis in COVID-19: a case report. 61
32641169 2020
20
Conjunctivitis: A Systematic Review. 61
32864068 2020
21
Effects of Floods on the Incidence of Acute Hemorrhagic Conjunctivitis in Mengshan, China, from 2005 to 2012. 61
32228794 2020
22
Epidemiological Characteristics and Spatiotemporal Analysis of Acute Hemorrhagic Conjunctivitis from 2004 to 2018 in Chongqing, China. 61
32518362 2020
23
Very late onset corneal haze in a photorefractive keratectomy patient associated with presumed viral keratoconjuctivitis. 61
32461475 2020
24
[A special on epidemic prevention and control:screening for novel coronavirus related conjunctivitis among the patients with coronavirus disease 2019]. 61
32295324 2020
25
Spontaneous reattachment of rhegmatogenous retinal detachment:about 5 cases. 61
33479968 2020
26
Ocular manifestations of a hospitalised patient with confirmed 2019 novel coronavirus disease. 61
32265202 2020
27
COVID-19 emergency in the cruise's ship: a case report of conjunctivitis. 61
32323704 2020
28
[Viral conjunctivitis due to molluscum contagiosum in a young immunocompetent woman]. 61
32327278 2020
29
Molecular typing of conjunctivitis-causing adenoviruses in Hanoi, Vietnam from 2017 to 2019 and complete genome analysis of the most prevalent type (HAdV-8). 61
32266999 2020
30
Ocular hypertension as a cause of cilioretinal artery obstruction in the young patient, about a case. 61
32143845 2020
31
Forecast of the trend in incidence of acute hemorrhagic conjunctivitis in China from 2011-2019 using the Seasonal Autoregressive Integrated Moving Average (SARIMA) and Exponential Smoothing (ETS) models. 61
31953020 2020
32
Methylene Blue Inhibits Acute Hemorrhagic Conjunctivitis Virus Production and Induction of Caspase-3 Mediated Human Corneal Cell Cytopathy. 61
33380782 2020
33
Comparative study on the efficacy of non-steroidal, steroid and non-use of anti-inflammatory in the treatment of acute epidemic conjunctivitis. 61
32049186 2020
34
Community-based surveillance advances the Global Health Security Agenda in Ghana. 61
32780775 2020
35
Viral conjunctivitis: a retrospective study in an Australian hospital. 61
31300283 2019
36
Content validity of a novel patient-reported and observer-reported outcomes assessment to evaluate ocular symptoms associated with infectious conjunctivitis in both adult and pediatric populations. 61
31666074 2019
37
Pharmacist Compliance With Therapeutic Guidelines on Diagnosis and Treatment Provision. 61
31314116 2019
38
Re-emergence of a coxsackievirus A24 variant causing acute hemorrhagic conjunctivitis in Brazil from 2017 to 2018. 61
30725183 2019
39
Acute depigmentation of the iris: a retrospective analysis of 22 cases. 61
30851772 2019
40
A randomized controlled trial of povidone-iodine/dexamethasone ophthalmic suspension for acute viral conjunctivitis. 61
30962674 2019
41
The Epidemic Genotypes of Human Adenovirus in Outpatient Children with Adenoviral Conjunctivitis from 2011 to 2012 in Jiangxi, China. 61
31117098 2019
42
Epidemiology and molecular diagnosis of acute conjunctivitis in patients attending Hamadan, west Iran ophthalmology clinics 2016-2017. 61
31686938 2019
43
Outbreak of Epidemic Keratoconjunctivitis Caused by Human Adenovirus Type D53 in an Eye Care Clinic - Los Angeles County, 2017. 61
30521501 2018
44
Photo Rounds: Painful facial blisters, fever, and conjunctivitis. 61
30216398 2018
45
Aetiology of neonatal conjunctivitis evaluated in a population-based setting. 61
29345007 2018
46
Seasonal distribution of ocular conditions treated at the emergency room: a 1-year prospective study. 61
29846426 2018
47
Conjunctival transcriptome profiling of Solomon Islanders with active trachoma in the absence of Chlamydia trachomatis infection. 61
29467021 2018
48
The tear cytokine profile in patients with active Graves' orbitopathy. 61
29147850 2018
49
Role of enhanced receptor engagement in the evolution of a pandemic acute hemorrhagic conjunctivitis virus. 61
29284752 2018
50
Sequelae from Epidemic Viral Conjunctivitis Can Be Associated with Inflammatory Trachoma in Schoolchildren? 61
27628039 2018

Variations for Acute Hemorrhagic Conjunctivitis

Expression for Acute Hemorrhagic Conjunctivitis

Search GEO for disease gene expression data for Acute Hemorrhagic Conjunctivitis.

Pathways for Acute Hemorrhagic Conjunctivitis

GO Terms for Acute Hemorrhagic Conjunctivitis

Cellular components related to Acute Hemorrhagic Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi membrane GO:0000139 9.26 SCARB2 PSEN2 OSBP CD55
2 membrane raft GO:0045121 8.8 PSEN2 ICAM1 CD55

Biological processes related to Acute Hemorrhagic Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral entry into host cell GO:0046718 8.8 SCARB2 ICAM1 CD55

Molecular functions related to Acute Hemorrhagic Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipid binding GO:0008289 9.26 OSBP CD55 BPIFB6 BPIFB3
2 virus receptor activity GO:0001618 8.8 SCARB2 ICAM1 CD55

Sources for Acute Hemorrhagic Conjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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