MCID: ACT012
MIFTS: 42

Acute Hemorrhagic Conjunctivitis

Categories: Eye diseases, Infectious diseases

Aliases & Classifications for Acute Hemorrhagic Conjunctivitis

MalaCards integrated aliases for Acute Hemorrhagic Conjunctivitis:

Name: Acute Hemorrhagic Conjunctivitis 12 15 17
Viral Conjunctivitis 12 17 74
Conjunctivitis, Acute Hemorrhagic 45 74
Epidemic Hemorrhagic Conjunctivitis 12
Apollo Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11227
ICD9CM 36 077.4
MeSH 45 D003232
NCIt 51 C34505
SNOMED-CT 69 31502007
ICD10 34 B30

Summaries for Acute Hemorrhagic Conjunctivitis

Disease Ontology : 12 A viral infectious disease that results in inflammation located in conjunctiva, has material basis in Human coxsackievirus A24 or has material basis in Human enterovirus 70, which are transmitted by contaminated fomites or transmitted by contact with contaminated hands. The infection has symptom vascular dilation, has symptom eyelid edema, has symptom photophobia, has symptom redness of the eyes, has symptom watering of the eye, has symptom conjunctival congestion, and has symptom superficial punctate epithelial keratitis.

MalaCards based summary : Acute Hemorrhagic Conjunctivitis, also known as viral conjunctivitis, is related to shipyard eye and conjunctivitis. An important gene associated with Acute Hemorrhagic Conjunctivitis is ICAM1 (Intercellular Adhesion Molecule 1), and among its related pathways/superpathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. The drugs Iodine and Povidone have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and kidney, and related phenotypes are hematopoietic system and immune system

Related Diseases for Acute Hemorrhagic Conjunctivitis

Diseases related to Acute Hemorrhagic Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 shipyard eye 29.8 PLD3 PSEN2
2 conjunctivitis 10.9
3 viral infectious disease 10.4
4 acute contagious conjunctivitis 10.2
5 conjunctivitis with pseudomembrane 10.2
6 acute conjunctivitis 10.1 PLD3 PSEN2
7 inclusion conjunctivitis 10.0 PLD3 PSEN2
8 conjunctival disease 10.0 PLD3 PSEN2
9 plasmodium falciparum malaria 9.9 CD55 ICAM1
10 dermatitis 9.8
11 keratoconjunctivitis 9.8
12 dysautonomia 9.8
13 myocarditis 9.8 CD55 ICAM1
14 dengue virus 9.8
15 dengue disease 9.8
16 trachoma 9.8
17 subacute thyroiditis 9.8
18 thyroiditis 9.8
19 vernal keratoconjunctivitis 9.8

Graphical network of the top 20 diseases related to Acute Hemorrhagic Conjunctivitis:



Diseases related to Acute Hemorrhagic Conjunctivitis

Symptoms & Phenotypes for Acute Hemorrhagic Conjunctivitis

MGI Mouse Phenotypes related to Acute Hemorrhagic Conjunctivitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 CD55 ICAM1 PLD3 PSEN2 ST3GAL6 ST8SIA1
2 immune system MP:0005387 8.92 ICAM1 PSEN2 ST3GAL6 ST8SIA1

Drugs & Therapeutics for Acute Hemorrhagic Conjunctivitis

Drugs for Acute Hemorrhagic Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational Phase 4,Phase 3 7553-56-2 807
2
Povidone Approved Phase 4,Phase 3 9003-39-8
3
Povidone-iodine Approved Phase 4,Phase 3 25655-41-8
4 Anti-Infective Agents, Local Phase 4,Phase 3
5 cadexomer iodine Phase 4,Phase 3
6 Nutrients Phase 4,Phase 3
7 Anti-Infective Agents Phase 4,Phase 3,Not Applicable
8 Trace Elements Phase 4,Phase 3
9 Plasma Substitutes Phase 4,Phase 3
10 Micronutrients Phase 4,Phase 3
11 Blood Substitutes Phase 4,Phase 3
12
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
13
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
14
Ketorolac Approved Phase 2, Phase 3 66635-83-4, 74103-06-3 3826
15 Gastrointestinal Agents Phase 3,Phase 2
16 glucocorticoids Phase 3
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
18 Pharmaceutical Solutions Phase 3,Phase 2,Not Applicable
19 Antineoplastic Agents, Hormonal Phase 3
20 Hormone Antagonists Phase 3
21 Antiemetics Phase 3
22 Autonomic Agents Phase 3
23 BB 1101 Phase 3
24 Lubricant Eye Drops Phase 3,Phase 2,Not Applicable
25 Ophthalmic Solutions Phase 3,Phase 2,Not Applicable
26
protease inhibitors Phase 3
27 Hormones Phase 3
28 Anti-Inflammatory Agents Phase 3,Phase 2
29 HIV Protease Inhibitors Phase 3
30 Peripheral Nervous System Agents Phase 3,Phase 2
31 Ketorolac Tromethamine Phase 2, Phase 3
32 Carboxymethylcellulose Sodium Phase 2, Phase 3
33 Cyclooxygenase Inhibitors Phase 2, Phase 3
34 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
35 Laxatives Phase 2, Phase 3
36 Analgesics Phase 2, Phase 3
37 Analgesics, Non-Narcotic Phase 2, Phase 3
38 Antirheumatic Agents Phase 2, Phase 3
39 Cathartics Phase 2, Phase 3
40
Ganciclovir Approved, Investigational Not Applicable 82410-32-0 3454
41 Ganciclovir triphosphate Not Applicable
42 Antiviral Agents Not Applicable
43 Nucleic Acid Synthesis Inhibitors Not Applicable

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Treatment of Epidemic Keratoconjunctivitis With 2% Povidone-iodine Completed NCT01179412 Phase 4 2% povidone-iodine;2% povidone-iodine
2 A Trial of Topical Dexamethasone Versus Artificial Tears for Treatment of Viral Conjunctivitis Completed NCT01481519 Phase 3 dexamethasone 0.1%/povidone-iodine 0.4%;Artificial Tears
3 Artificial Tears Versus Preservative Free Ketorolac Trometamol 0.45% for Acute Viral Conjunctivitis Completed NCT01799863 Phase 2, Phase 3 Ketorolac trometamol 0.45% with carboxymethylcellulose;Preservative free artificial tear
4 FST-100 in the Treatment of Acute Viral Conjunctivitis Completed NCT01461954 Phase 2 FST-100;FST-100 Vehicle
5 Therapeutic Efficacy of APD-209 Eye Drops in Treatment of Epidemic Keratoconjunctivitis (EKC) Completed NCT01977443 Phase 2 APD-209 Eye drops;APD-209 Placebo Eye drops
6 Trial to Evaluate the Efficacy and Safety of IVIEW-1201 in Acute Viral Conjunctivitis Not yet recruiting NCT03749317 Phase 2 IVIEW-1201;Placebo
7 ADenoVirus Initiative Study in Epidemiology in Italy Completed NCT03055065
8 ADenoVirus Initiative Study in Epidemiology in Spain Completed NCT02254330
9 ADenoVirus Initiative Study in Epidemiology in UK Completed NCT02112773
10 ADenoVirus Initiative Study in Epidemiology in Germany Completed NCT02054273
11 ADenoVirus Initiative Study in Epidemiology in France Completed NCT02054234
12 Evaluation of a Rapid Screening Test for Detection of Adenovirus in Tears Completed NCT00266734 Not Applicable
13 A Comparison of the RPS Adeno Detector IV to Viral Cell Culture at Detecting Adenoviral Conjunctivitis Completed NCT00921895 Not Applicable
14 Ganciclovir 0,15% Ophthalmic Gel in the Treatment of Adenovirus Keratoconjuntivitis Completed NCT01349452 Not Applicable Ganciclovir;Artificial tear
15 Viral Conjunctivitis Treatment Study Recruiting NCT03861728 Not Applicable

Search NIH Clinical Center for Acute Hemorrhagic Conjunctivitis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: conjunctivitis, acute hemorrhagic

Genetic Tests for Acute Hemorrhagic Conjunctivitis

Anatomical Context for Acute Hemorrhagic Conjunctivitis

MalaCards organs/tissues related to Acute Hemorrhagic Conjunctivitis:

42
Eye, Testes, Kidney, Colon, Endothelial, Thyroid

Publications for Acute Hemorrhagic Conjunctivitis

Articles related to Acute Hemorrhagic Conjunctivitis:

(show top 50) (show all 143)
# Title Authors Year
1
Re-emergence of a coxsackievirus A24 variant causing acute hemorrhagic conjunctivitis in Brazil from 2017 to 2018. ( 30725183 )
2019
2
Role of enhanced receptor engagement in the evolution of a pandemic acute hemorrhagic conjunctivitis virus. ( 29284752 )
2018
3
Molecular epidemiology of acute hemorrhagic conjunctivitis caused by coxsackie A type 24 variant in China, 2004-2014. ( 28332617 )
2017
4
Acute hemorrhagic conjunctivitis epidemic in SALo Paulo State, Brazil, 2011. ( 27754516 )
2016
5
Acute hemorrhagic conjunctivitis: anti-coxsackievirus A24 variant secretory immunoglobulin A in acute and convalescent tear. ( 26392747 )
2015
6
Virological and epidemiological analysis of coxsackievirus A24 variant epidemic of acute hemorrhagic conjunctivitis in Okinawa, Japan, in 2011. ( 26109843 )
2015
7
Molecular evolution of VP3, VP1, 3C(pro) and 3D(pol) coding regions in coxsackievirus group A type 24 variant isolates from acute hemorrhagic conjunctivitis in 2011 in Okinawa, Japan. ( 24517637 )
2014
8
Genetic characteristics of the coxsackievirus A24 variant causing outbreaks of acute hemorrhagic conjunctivitis in Jiangsu, China, 2010. ( 24475191 )
2014
9
Artificial tears alone versus 0.45% ketorolac tromethamine with artificial tears for the treatment of acute viral conjunctivitis. ( 25076474 )
2014
10
Appropriate prescribing for viral conjunctivitis. ( 25551873 )
2014
11
Molecular identification and phylogenetic study of coxsackievirus A24 variant isolated from an outbreak of acute hemorrhagic conjunctivitis in India in 2010. ( 23124888 )
2013
12
A molecular investigative approach to an outbreak of acute hemorrhagic conjunctivitis in Egypt, October 2010. ( 23531270 )
2013
13
Phylogenetic and molecular characterization of coxsackievirus A24 variant isolates from a 2010 acute hemorrhagic conjunctivitis outbreak in Guangdong, China. ( 22336176 )
2012
14
Molecular characterization and phylogenetic study of coxsackievirus A24v causing outbreaks of acute hemorrhagic conjunctivitis (AHC) in Brazil. ( 21858030 )
2011
15
An antiviral small-interfering RNA simultaneously effective against the most prevalent enteroviruses causing acute hemorrhagic conjunctivitis. ( 20739472 )
2011
16
Outbreak of acute hemorrhagic conjunctivitis in Yunnan, People's Republic of China, 2007. ( 20579343 )
2010
17
Understanding of acute hemorrhagic conjunctivitis (AHC) epidemics and outbreaks of Paederus spp keratoconjuctivitis, periorbital oedema ("Nairobi red eyes") and dermatitis. ( 21516962 )
2010
18
Notes from the field: acute hemorrhagic conjunctivitis outbreaks caused by coxsackievirus A24v --- Uganda and southern Sudan, 2010. ( 20724969 )
2010
19
[Outbreak of acute hemorrhagic conjunctivitis in Beijing City in 2007 caused by coxsackievirus A24 variant: molecular identification and phylogenetic analysis]. ( 19769156 )
2009
20
Multiple outbreaks of acute hemorrhagic conjunctivitis due to a variant of coxsackievirus A24: Guangdong, China, 2007. ( 18712817 )
2008
21
An outbreak of acute hemorrhagic conjunctivitis (AHC) caused by coxsackievirus A24 variant in Pakistan. ( 18638510 )
2008
22
Outbreak of acute hemorrhagic conjunctivitis in Maharashtra and Gujarat states of India, caused by Coxsackie virus A-24 variant. ( 17457917 )
2007
23
Rapid diagnosis of acute hemorrhagic conjunctivitis due to coxsackievirus A24 variant by real-time one-step RT-PCR. ( 17328967 )
2007
24
Molecular identification of coxsackievirus A24 variant, isolated from an outbreak of acute hemorrhagic conjunctivitis in Singapore in 2005. ( 17680326 )
2007
25
Two outbreaks of acute hemorrhagic conjunctivitis in Africa due to genotype III coxsackievirus A24 variant. ( 17294159 )
2007
26
Acute hemorrhagic conjunctivitis and coxsackievirus A24v, Rio de Janeiro, Brazil, 2004. ( 16704792 )
2006
27
Viral investigation of acute hemorrhagic conjunctivitis outbreak (2003) in Nepal using molecular methods. ( 17333732 )
2006
28
Acute hemorrhagic conjunctivitis epidemic caused by coxsackievirus A24 variants in Korea during 2002-2003. ( 16299722 )
2006
29
Viral conjunctivitis interfering with the clinical activity score and management of thyroid ophthalmopathy. ( 16527772 )
2006
30
Outbreak of acute hemorrhagic conjunctivitis in French Guiana and West Indies caused by coxsackievirus A24 variant: phylogenetic analysis reveals Asian import. ( 15714481 )
2005
31
Rapid identification of the coxsackievirus A24 variant by molecular serotyping in an outbreak of acute hemorrhagic conjunctivitis. ( 15750062 )
2005
32
Towards an in vitro model for acute hemorrhagic conjunctivitis: cytokine-mediated vascular endothelial cell activation triggered by enterovirus type 70 infection. ( 15072749 )
2004
33
Acute hemorrhagic conjunctivitis outbreak caused by Coxsackievirus A24--Puerto Rico, 2003. ( 15269699 )
2004
34
Epidemiologic investigation into the outbreak of acute hemorrhagic conjunctivitis in gyeongju-city, South Korea, in 2002. ( 25175612 )
2004
35
Acute hemorrhagic conjunctivitis epidemic--2003 in Nepal. ( 15024766 )
2003
36
Acute hemorrhagic conjunctivitis caused by coxsackievirus A24 variant, South Korea, 2002. ( 12967504 )
2003
37
Systemic and ocular antibody responses to inactivated acute hemorrhagic conjunctivitis (AHC) virus; enterovirus 70 (EV70). ( 14566646 )
2003
38
Treatment of viral conjunctivitis in children. ( 12751650 )
2003
39
The change of etiological agents and clinical signs of epidemic viral conjunctivitis over an 18-year period in southern Taiwan. ( 12768288 )
2003
40
A randomized, double-masked trial of topical ketorolac versus artificial tears for treatment of viral conjunctivitis. ( 10919900 )
2000
41
Acute hemorrhagic conjunctivitis due to enterovirus 70 in India. ( 10221880 )
1999
42
Ten years' surveillance of viral conjunctivitis in Sapporo, Japan. ( 9951639 )
1999
43
Corneal superinfection in acute hemorrhagic conjunctivitis. ( 9820942 )
1998
44
From the Centers for Disease Control and Prevention. Acute hemorrhagic conjunctivitis--St Croix, US Virgin Islands, September-October 1998. ( 9842938 )
1998
45
Acute hemorrhagic conjunctivitis--St. Croix, U.S. Virgin Islands, September-October 1998. ( 9810014 )
1998
46
Acute red eye. Differentiating viral conjunctivitis from other, less common causes. ( 9158614 )
1997
47
Detection of enterovirus 70 by polymerase chain reaction in acute hemorrhagic conjunctivitis. ( 8694103 )
1996
48
Acute hemorrhagic conjunctivitis outbreak in Thailand, 1992. ( 9279984 )
1996
49
Community-based investigation of an outbreak of acute viral conjunctivitis in urban slums. ( 8911451 )
1996
50
Inhibition of the enteroviruses that cause acute hemorrhagic conjunctivitis (AHC) by benzimidazoles; enviroxime (LY 122772) and enviradone (LY 127123). ( 8540755 )
1995

Variations for Acute Hemorrhagic Conjunctivitis

Expression for Acute Hemorrhagic Conjunctivitis

Search GEO for disease gene expression data for Acute Hemorrhagic Conjunctivitis.

Pathways for Acute Hemorrhagic Conjunctivitis

Pathways related to Acute Hemorrhagic Conjunctivitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.19 CD55 ST3GAL6 ST6GAL2 ST6GALNAC5 ST8SIA1
2
Show member pathways
12.44 CD55 ST3GAL6 ST6GAL2 ST6GALNAC5 ST8SIA1
3
Show member pathways
11.55 ST3GAL6 ST6GAL2 ST6GALNAC5 ST8SIA1
4
Show member pathways
10.77 ST6GALNAC5 ST8SIA1
5 10.69 ST3GAL6 ST8SIA1
6
Show member pathways
10.37 ST6GAL2 ST6GALNAC5 ST8SIA1

GO Terms for Acute Hemorrhagic Conjunctivitis

Cellular components related to Acute Hemorrhagic Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.8 ICAM1 PLD3 PSEN2 ST3GAL6 ST6GAL2 ST6GALNAC5
2 membrane GO:0016020 9.76 CD55 ICAM1 PLD3 PSEN2 ST3GAL6 ST6GAL2
3 Golgi apparatus GO:0005794 9.35 PSEN2 ST3GAL6 ST6GAL2 ST6GALNAC5 ST8SIA1
4 Golgi membrane GO:0000139 9.1 CD55 PSEN2 ST3GAL6 ST6GAL2 ST6GALNAC5 ST8SIA1

Biological processes related to Acute Hemorrhagic Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral entry into host cell GO:0046718 9.37 CD55 ICAM1
2 cellular response to interleukin-6 GO:0071354 9.32 ICAM1 ST3GAL6
3 oligosaccharide metabolic process GO:0009311 9.26 ST3GAL6 ST6GAL2
4 protein glycosylation GO:0006486 9.26 ST3GAL6 ST6GAL2 ST6GALNAC5 ST8SIA1
5 glycosphingolipid biosynthetic process GO:0006688 9.16 ST6GALNAC5 ST8SIA1
6 sialylation GO:0097503 8.92 ST3GAL6 ST6GAL2 ST6GALNAC5 ST8SIA1

Molecular functions related to Acute Hemorrhagic Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transferase activity, transferring glycosyl groups GO:0016757 9.26 ST3GAL6 ST6GAL2 ST6GALNAC5 ST8SIA1
2 virus receptor activity GO:0001618 9.16 CD55 ICAM1
3 sialyltransferase activity GO:0008373 8.92 ST3GAL6 ST6GAL2 ST6GALNAC5 ST8SIA1

Sources for Acute Hemorrhagic Conjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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