AIR
MCID: ACT088
MIFTS: 41

Acute Insulin Response (AIR)

Aliases & Classifications for Acute Insulin Response

MalaCards integrated aliases for Acute Insulin Response:

Name: Acute Insulin Response 56 13
Air 56

External Ids:

OMIM 56 601676

Summaries for Acute Insulin Response

MalaCards based summary : Acute Insulin Response, also known as air, is related to sleep apnea and apnea, obstructive sleep. An important gene associated with Acute Insulin Response is AIR (Acute Insulin Response (2)), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Glucose / Energy Metabolism. The drugs Rosiglitazone and Metformin have been mentioned in the context of this disorder. Affiliated tissues include testes, pancreatic islet and ovary, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and Reduced mammosphere formation

More information from OMIM: 601676

Related Diseases for Acute Insulin Response

Diseases related to Acute Insulin Response via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1787)
# Related Disease Score Top Affiliating Genes
1 sleep apnea 32.0 INS CRP ADRB2
2 apnea, obstructive sleep 31.9 INS GCG CRP
3 decubitus ulcer 30.5 INS CRP
4 congestive heart failure 30.3 INS CRP ADRB2
5 mediastinitis 30.1 INS CRP
6 hyperinsulinemic hypoglycemia, familial, 6 30.0 UCP2 ABCC8
7 mucormycosis 30.0 INS CRP
8 dumping syndrome 29.9 INS GCG
9 fatty liver disease 29.9 UCP2 INS CRP
10 hyperinsulinemic hypoglycemia, familial, 2 29.8 KCNJ11 INS ABCC8
11 volvulus of midgut 29.8 GCG CRP
12 meckel diverticulum 29.7 GCG CRP
13 hyperglycemia 29.7 KCNJ11 INS GCG ABCC8
14 drug allergy 29.5 INS CRP
15 diabetes mellitus, ketosis-prone 29.4 KCNJ11 INS GCG ABCC8
16 hypoglycemia 29.4 KCNJ5 KCNJ11 INS GCG ABCC8
17 asphyxia neonatorum 29.4 KCNJ11 INS CRP ABCC8
18 coronary artery vasospasm 29.3 CRP ADRB2
19 pancreatitis 29.3 INS GCG CRP
20 non-alcoholic fatty liver disease 29.2 UCP2 INS GCG CRP
21 hyperinsulinism 29.2 UCP2 KCNJ5 KCNJ11 INS GCG ABCC8
22 stomach disease 29.1 INS GCG CRP
23 lipid metabolism disorder 29.0 TCF7L2 INS CRP
24 leptin deficiency or dysfunction 29.0 UCP1 INS GCG CRP
25 constipation 28.9 INS GCG CRP
26 glucose metabolism disease 28.8 KCNJ11 INS GCG CRP
27 gestational diabetes 28.7 TCF7L2 KCNJ11 INS GCG CRP ABCC8
28 diabetes mellitus, type i 28.5 UCP1 INS GCG CRP ADRB2
29 overnutrition 28.4 UCP2 UCP1 INS GCG CRP
30 prediabetes syndrome 28.2 TCF7L2 INS GCG CRP
31 glucose intolerance 27.8 UCP2 TCF7L2 KCNJ11 INS GCG CRP
32 hypertension, essential 27.8 UCP2 UCP1 KCNJ5 INS GCG CRP
33 diabetes mellitus 26.4 UCP2 UCP1 TCF7L2 PIK3R1 KCNJ5 KCNJ11
34 body mass index quantitative trait locus 11 26.3 UCP2 UCP1 TCF7L2 PIK3R1 KCNJ11 INS
35 diabetes mellitus, noninsulin-dependent 25.5 UCP2 UCP1 TCF7L2 PYGM PIK3R1 KCNJ5
36 mental retardation, buenos aires type 12.6
37 ventilation pneumonitis 12.1
38 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 12.0
39 pulmonary disease, chronic obstructive 11.9
40 pneumothorax, primary spontaneous 11.8
41 pneumothorax 11.6
42 respiratory failure 11.6
43 lung disease 11.6
44 bronchitis 11.6
45 allergic rhinitis 11.6
46 pleural disease 11.5
47 sick building syndrome 11.5
48 mastoiditis 11.5
49 tracheal disease 11.5
50 pneumonia 11.5

Graphical network of the top 20 diseases related to Acute Insulin Response:



Diseases related to Acute Insulin Response

Symptoms & Phenotypes for Acute Insulin Response

Clinical features from OMIM:

601676

GenomeRNAi Phenotypes related to Acute Insulin Response according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 9.13 INS PIK3R1 TCF7L2
2 Reduced mammosphere formation GR00396-S 9.1 ABCC8 KCNJ11 KCNJ5 PIK3R1 PYGM UCP2

MGI Mouse Phenotypes related to Acute Insulin Response:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.73 ADRB2 INS KCNJ11 PIK3R1 TCF7L2 UCP1
2 endocrine/exocrine gland MP:0005379 9.7 ABCC8 ADRB2 INS KCNJ11 PIK3R1 TCF7L2
3 homeostasis/metabolism MP:0005376 9.65 ABCC8 ADRB2 CRP INS KCNJ11 PIK3R1
4 muscle MP:0005369 9.1 ADRB2 INS KCNJ11 PIK3R1 PYGM TCF7L2

Drugs & Therapeutics for Acute Insulin Response

Drugs for Acute Insulin Response (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rosiglitazone Approved, Investigational Phase 4 122320-73-4 77999
2
Metformin Approved Phase 4 657-24-9 14219 4091
3
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
4
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
5
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
6
Clozapine Approved Phase 4 5786-21-0 2818
7 glucocorticoids Phase 4
8 Hydrocortisone 17-butyrate 21-propionate Phase 4
9 Anti-Inflammatory Agents Phase 4
10 Hydrocortisone hemisuccinate Phase 4
11 HIV Protease Inhibitors Phase 4
12
protease inhibitors Phase 4
13 Sitagliptin Phosphate Phase 4
14 Dipeptidyl-Peptidase IV Inhibitors Phase 4
15 Hypolipidemic Agents Phase 3
16 Colesevelam Hydrochloride Phase 3
17 Anticholesteremic Agents Phase 3
18 Lipid Regulating Agents Phase 3
19 Antimetabolites Phase 3
20
Clotrimazole Approved, Vet_approved Phase 1, Phase 2 23593-75-1 2812
21
Tacrolimus Approved, Investigational Phase 1, Phase 2 104987-11-3 445643 439492 6473866
22
Mycophenolic acid Approved Phase 1, Phase 2 24280-93-1 446541
23
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
24
tannic acid Approved Phase 1, Phase 2 1401-55-4
25
Etanercept Approved, Investigational Phase 1, Phase 2 185243-69-0
26
Benzocaine Approved, Investigational Phase 1, Phase 2 94-09-7, 1994-09-7 2337
27
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 5284616 6436030 46835353
28 Immunosuppressive Agents Phase 1, Phase 2
29 Gastrointestinal Agents Phase 1, Phase 2
30 Antitubercular Agents Phase 1, Phase 2
31 Analgesics, Non-Narcotic Phase 1, Phase 2
32 Anti-Infective Agents Phase 1, Phase 2
33 Anti-Bacterial Agents Phase 1, Phase 2
34 Analgesics Phase 1, Phase 2
35 Antifungal Agents Phase 1, Phase 2
36 Immunologic Factors Phase 1, Phase 2
37 Calcineurin Inhibitors Phase 1, Phase 2
38 Thymoglobulin Phase 1, Phase 2
39 Antibiotics, Antitubercular Phase 1, Phase 2
40 Antirheumatic Agents Phase 1, Phase 2
41 Antilymphocyte Serum Phase 1, Phase 2
42 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
43
Exenatide Approved, Investigational Phase 1 141758-74-9 15991534
44
Altretamine Approved Phase 1 645-05-6 2123
45
Heparin Approved, Investigational Phase 1 9005-49-6 46507594 772
46
Phenol Approved, Experimental Phase 1 108-95-2 996
47 Anti-Obesity Agents Phase 1
48 calcium heparin Phase 1
49
Glucagon Approved 16941-32-5
50
Pancrelipase Approved, Investigational 53608-75-6

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 Effects of Insulin Sensitizers in Subjects With Impaired Glucose Tolerance Completed NCT00108615 Phase 4 Metformin;Pioglitazone;Metformin;Pioglitazone
2 Rapid Effects of Hydrocortisone on Glucose-induced Insulin Secretion in Healthy Humans Completed NCT00709839 Phase 4 Hydrocortisone;Glucose 33%
3 A Double-Blind, Placebo-Controlled Trial of Rosiglitazone for Clozapine Induced Glucose Metabolism Impairment: Bergman's Minimal Model Analysis Completed NCT00337350 Phase 4 rosiglitazone;placebo
4 Phase IV Study Evaluating the Effect of Sitagliptin (Januvia™) on Beta-cell Function in Patients With Acute Myocardial Infarction or Unstable Angina Pectoris and Newly Detected Impaired Glucose Tolerance or Type 2 Diabetes. Completed NCT00627744 Phase 4 Sitagliptin
5 Liraglutide Actions on the Liver: Effects on Glucose Phosphorylation Withdrawn NCT02198209 Phase 4 Liraglutide
6 A Single-Blind Study to Evaluate the Effects of Colesevelam on Insulin Sensitivity and ß-Cell Function in Subjects With Impaired Fasting Glucose (Prediabetes) Completed NCT00990184 Phase 3 Colesevelam
7 Allogeneic Islet Cells Transplanted Into the Omentum Completed NCT02821026 Phase 1, Phase 2 Anti-Thymocyte Globulin;Mycophenolate mofetil;Tacrolimus;Etanercept;Sirolimus
8 Randomized Trial Investigating Exenatide for Diabetes Prevention in Obese, Insulin-Resistant Individuals With Prediabetes Completed NCT02084654 Phase 1 Exenatide 5 and 10 mcg 2 times a day;placebo
9 Islet Allotransplantation in Type 1 Diabetes Enrolling by invitation NCT01705899 Phase 1 Human Pancreatic Islets
10 Changes in Glucose Metabolism After Roux-en-Y Gastric Bypass Unknown status NCT01993511
11 Effects of Progressive Negative Energy Balance Induced by Diet or Exercise on Glucose Tolerance, Insulin Sensitivity, and Beta-cell Function Unknown status NCT03264001
12 The Aging Endocrine Pancreas: Characterization of the Entero-insular Axis Physiology in the Elderly. Completed NCT00843479
13 Physiopathology of Type 2 Diabetes Initiated After Sixty Years Old: Characterization of a Diabetic-related Incretinpathy in Aging Subjects. Completed NCT00843232
14 Effects of Rosiglitazone on the Metabolic Phenotype of Impaired Glucose Tolerance in Youth Completed NCT00413335 Rosiglitazone;Placebo
15 Effects of Sucralose on Insulin Sensitivity, Pancreatic Response and Appetite Regulating Hormones Completed NCT02589002
16 USC Center for Transdisciplinary Research on Energetics and Cancer or Obesity-Related Metabolic Disease Risk: Response to Exercise in Minority Youth Completed NCT01441323
17 Defining the Molecular and Physiological Mechanisms of Pancreatic Islet Cell Dysfunction Which Lead to Type 2 Diabetes (DIabetes VAriants) Completed NCT02505308
18 Prospective Randomized Controlled Trial on the Effect of Gastric Bypass and Biliopancreatic Diversion on Type 2 Diabetes Mellitus in Patients With BMI > 35 vs. Medical Therapy Completed NCT00888836
19 B-type Natriuretic Peptide Affects the Initial Response to Intravenous Glucose in a Placebo-controlled Cross-over Study in Healthy Volunteers Completed NCT01324739 human BNP-32
20 Effects of Chronic Dietary Exposure to Branched Chain Amino Acids on Insulin Sensitivity Measures in Healthy Vegans and Omnivores Completed NCT02684929
21 Very Low Calorie Diet: a Quick Therapeutic Tool to Improve Beta Cell Function in Morbidly Obese Patients With Type 2 Diabetes Mellitus Completed NCT01447524
22 Assessing Progression to Type-2 Diabetes (APT-2D): A Prospective Cohort Study Expanded From BRITE-SPOT (Bio-bank and Registry for StratIfication and Targeted intErventions in the Spectrum Of Type 2 Diabetes) Recruiting NCT02838693
23 Epigenetic Regulation of Human Adipose Tissue Distribution Active, not recruiting NCT02728635
24 EnVision CF Multicenter Study of Glucose Tolerance in Cystic Fibrosis Not yet recruiting NCT03650712

Search NIH Clinical Center for Acute Insulin Response

Genetic Tests for Acute Insulin Response

Anatomical Context for Acute Insulin Response

MalaCards organs/tissues related to Acute Insulin Response:

40
Testes, Pancreatic Islet, Ovary, Liver, B Cells, Pancreas, Brain

Publications for Acute Insulin Response

Articles related to Acute Insulin Response:

(show top 50) (show all 775)
# Title Authors PMID Year
1
A physical map at 1p31 encompassing the acute insulin response locus and the leptin receptor. 56 61
9027510 1997
2
Evidence for linkage between a region on chromosome 1p and the acute insulin response in Pima Indians. 56 61
7698519 1995
3
Longitudinal Study on Metabolic Health in Adults SGA During 5 Years After GH With or Without 2 Years of GnRHa Treatment. 61
32436961 2020
4
Adipocyte Insulin Resistance in PCOS: Relationship With GLUT-4 Expression and Whole-Body Glucose Disposal and β-Cell Function. 61
32382742 2020
5
Long-term Metabolic and Socioeducational Outcomes of Transient Neonatal Diabetes: A Longitudinal and Cross-sectional Study. 61
32273272 2020
6
The Impact of Obesity On Insulin Sensitivity and Secretion During Pubertal Progression: A Longitudinal Study. 61
31996919 2020
7
Trafficking of nonesterified fatty acids in insulin resistance and relationship to dysglycemia. 61
31910030 2020
8
Different β-cell secretory phenotype in non-obese compared to obese early type 2 diabetes. 61
32017362 2020
9
Decreased Plasma Maresin 1 Concentration Is Associated with Diabetic Foot Ulcer. 61
32377160 2020
10
The effects of dietary nitrate on plasma glucose and insulin sensitivity in sheep. 61
31418937 2019
11
Dose-Dependent Effects of Exercise and Diet on Insulin Sensitivity and Secretion. 61
31033904 2019
12
Sex Differences in Effects of Obesity on Reproductive Hormones and Glucose Metabolism in Early Puberty. 61
30985874 2019
13
Conjugated Estrogens and Bazedoxifene Improve β Cell Function in Obese Menopausal Women. 61
31384719 2019
14
Utility of arginine stimulation testing in preoperative assessment of children undergoing total pancreatectomy with islet autotransplantation. 61
31230395 2019
15
Recent evidence for the effects of nonnutritive sweeteners on glycaemic control. 61
31033578 2019
16
Mitochondrial mutation m.3243A>G associates with insulin resistance in non-diabetic carriers. 61
31146262 2019
17
Insulin Sensitivity Is Associated with Lipoprotein Lipase (LPL) and Catenin Delta 2 (CTNND2) DNA Methylation in Peripheral White Blood Cells in Non-Diabetic Young Women. 61
31208038 2019
18
Two nights of recovery sleep restores the dynamic lipemic response, but not the reduction of insulin sensitivity, induced by five nights of sleep restriction. 61
30892916 2019
19
Predictors of Long-Term Glycemic Remission After 2-Week Intensive Insulin Treatment in Newly Diagnosed Type 2 Diabetes. 61
30629195 2019
20
Adipose Insulin Resistance in Normal-Weight Women With Polycystic Ovary Syndrome. 61
30649347 2019
21
Oral Glucose Tolerance Testing Allows Better Prediction of Diabetes in Women with a History of Gestational Diabetes Mellitus. 61
30604595 2019
22
Effects of dietary fat on insulin secretion in subjects with the metabolic syndrome. 61
30893645 2019
23
Adipocyte expression of glucose transporter 1 and 4 in PCOS: Relationship to insulin-mediated and non-insulin-mediated whole-body glucose uptake. 61
30623452 2019
24
Insulin function in obese children within the low and high ranges of impaired fasting glycemia. 61
30537059 2019
25
Pathogenic Mechanisms of Prediabetes in Obese vs. Very Obese African American Women: Implications for Diabetes Prevention. 61
30032866 2019
26
Disposition Index in Active Acromegaly. 61
31620090 2019
27
Risk of diabetes associated with fatty acids in the de novo lipogenesis pathway is independent of insulin sensitivity and response: the Insulin Resistance Atherosclerosis Study (IRAS). 61
31543975 2019
28
Postprandial Insulin Response and Clearance Among Black and White Women: The Federal Women's Study. 61
30260396 2019
29
Effects of medium chain triglycerides supplementation on insulin sensitivity and beta cell function: A feasibility study. 61
31869355 2019
30
Decreased VMAT2 in the pancreas of humans with type 2 diabetes mellitus measured in vivo by PET imaging. 61
29721633 2018
31
Effects of overconditioning on pancreatic insulin secretory capacity, fat infiltration, and the number and size of islets in dairy cows at the end of the dry period. 61
30316589 2018
32
Effects of sucralose on insulin and glucagon-like peptide-1 secretion in healthy subjects: a randomized, double-blind, placebo-controlled trial. 61
30005329 2018
33
Genome-wide interaction with the insulin secretion locus MTNR1B reveals CMIP as a novel type 2 diabetes susceptibility gene in African Americans. 61
29691896 2018
34
Effects of age and diet on glucose and insulin dynamics in the horse. 61
29356053 2018
35
Sucralose decreases insulin sensitivity in healthy subjects: a randomized controlled trial. 61
30535090 2018
36
Relationship between serum adipsin and the first phase of glucose-stimulated insulin secretion in individuals with different glucose tolerance. 61
29432659 2018
37
Pathophysiological Characteristics Underlying Different Glucose Response Curves: A Latent Class Trajectory Analysis From the Prospective EGIR-RISC Study. 61
29853473 2018
38
Contribution of parasympathetic muscarinic augmentation of insulin secretion to olanzapine-induced hyperinsulinemia. 61
29351487 2018
39
Fimasartan increases glucose-stimulated insulin secretion in patients with type 2 diabetes and hypertension compared with amlodipine. 61
29546730 2018
40
Lower mean blood glucose during short-term intensive insulin therapy is associated with long-term glycemic remission in patients with newly diagnosed type 2 diabetes: Evidence-based recommendations for standardization. 61
29193795 2018
41
Outpatient versus inpatient mixed meal tolerance and arginine stimulation testing yields comparable measures of variability for assessment of beta cell function. 61
30023442 2018
42
Sequential Treatment Escalation with Dapagliflozin and Saxagliptin Improves Beta Cell Function in Type 2 Diabetic Patients on Previous Metformin Treatment: An Exploratory Mechanistic Study. 61
29727906 2018
43
Endothelial dysfunction of coronary arteries in subjects without diabetes: An association with both insulin resistance and impaired insulin secretion response. 61
29526680 2018
44
Metabolomics Identifies Distinctive Metabolite Signatures for Measures of Glucose Homeostasis: The Insulin Resistance Atherosclerosis Family Study (IRAS-FS). 61
29546329 2018
45
Prospective evaluation of insulin and incretin dynamics in obese adults with and without diabetes for 2 years after Roux-en-Y gastric bypass. 61
29428999 2018
46
Early deficits in insulin secretion, beta cell mass and islet blood perfusion precede onset of autoimmune type 1 diabetes in BioBreeding rats. 61
29209740 2018
47
Pioglitazone Improved Insulin Sensitivity and First Phase Insulin Secretion Among Obese and Lean People with Diabetes: A Multicenter Clamp Study. 61
29536426 2018
48
Effect of age and dietary carbohydrate profiles on glucose and insulin dynamics in horses. 61
28833406 2018
49
Role of resistant starch on diabetes risk factors in people with prediabetes: Design, conduct, and baseline results of the STARCH trial. 61
29274892 2018
50
Pilot study of sleep and meal timing effects, independent of sleep duration and food intake, on insulin sensitivity in healthy individuals. 61
29332677 2018

Variations for Acute Insulin Response

Expression for Acute Insulin Response

Search GEO for disease gene expression data for Acute Insulin Response.

Pathways for Acute Insulin Response

Pathways related to Acute Insulin Response according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.5 TCF7L2 KCNJ5 KCNJ11 INS GCG ABCC8
2 12.25 UCP2 UCP1 INS GCG
3
Show member pathways
12.07 KCNJ11 INS GCG ABCC8
4
Show member pathways
11.97 TCF7L2 INS GCG
5
Show member pathways
11.87 KCNJ5 KCNJ11 ABCC8
6
Show member pathways
11.73 KCNJ5 KCNJ11 ABCC8
7
Show member pathways
11.69 PYGM PIK3R1 INS
8
Show member pathways
11.44 PIK3R1 KCNJ11 INS ABCC8
9 11.42 PIK3R1 KCNJ5 KCNJ11
10 11.29 PIK3R1 INS ADRB2
11 11.21 PIK3R1 KCNJ11 ABCC8
12 11 KCNJ5 KCNJ11 ADRB2 ABCC8
13
Show member pathways
10.69 UCP2 UCP1
14 10.57 UCP2 KCNJ11 INS ABCC8

GO Terms for Acute Insulin Response

Cellular components related to Acute Insulin Response according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inward rectifying potassium channel GO:0008282 8.62 KCNJ11 ABCC8

Biological processes related to Acute Insulin Response according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase B signaling GO:0051897 9.7 TCF7L2 PIK3R1 INS
2 potassium ion transport GO:0006813 9.63 KCNJ5 KCNJ11 ABCC8
3 positive regulation of cold-induced thermogenesis GO:0120162 9.58 UCP2 UCP1 ADRB2
4 negative regulation of insulin secretion GO:0046676 9.54 KCNJ11 ABCC8
5 mitochondrial transport GO:0006839 9.51 UCP2 UCP1
6 cellular glucose homeostasis GO:0001678 9.49 PIK3R1 ABCC8
7 regulation of protein localization to plasma membrane GO:1903076 9.48 PIK3R1 INS
8 diet induced thermogenesis GO:0002024 9.43 UCP1 ADRB2
9 negative regulation of blood vessel diameter GO:0097756 9.37 INS CRP
10 adaptive thermogenesis GO:1990845 9.32 UCP2 UCP1
11 mitochondrial transmembrane transport GO:1990542 9.26 UCP2 UCP1
12 inorganic cation transmembrane transport GO:0098662 9.16 KCNJ11 ABCC8
13 regulation of insulin secretion GO:0050796 9.13 KCNJ11 GCG ABCC8
14 response to cold GO:0009409 8.8 UCP2 UCP1 ADRB2

Molecular functions related to Acute Insulin Response according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor binding GO:0005158 9.37 PIK3R1 INS
2 inward rectifier potassium channel activity GO:0005242 9.32 KCNJ5 KCNJ11
3 cation-transporting ATPase activity GO:0019829 9.26 KCNJ11 ABCC8
4 insulin-like growth factor receptor binding GO:0005159 9.16 PIK3R1 INS
5 ATP-activated inward rectifier potassium channel activity GO:0015272 8.96 KCNJ11 ABCC8
6 oxidative phosphorylation uncoupler activity GO:0017077 8.62 UCP2 UCP1

Sources for Acute Insulin Response

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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