Aliases & Classifications for Acute Insulin Response

MalaCards integrated aliases for Acute Insulin Response:

Name: Acute Insulin Response 57 13
Air 57 3

External Ids:

OMIM 57 601676

Summaries for Acute Insulin Response

CDC : 3 Outdoor air quality has improved since the 1990s, but many challenges remain in protecting Americans from air quality problems. Ground-level ozone, the main part of smog, and particle pollution are just two of the many threats to air quality and public health in the United States.

MalaCards based summary : Acute Insulin Response, also known as air, is related to apnea, obstructive sleep and hyperinsulinism. An important gene associated with Acute Insulin Response is AIR (Acute Insulin Response (2)), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Glucose / Energy Metabolism. The drugs Liraglutide and Pioglitazone have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreatic islet and ovary, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and Reduced mammosphere formation

Description from OMIM: 601676

Related Diseases for Acute Insulin Response

Diseases related to Acute Insulin Response via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 156)
# Related Disease Score Top Affiliating Genes
1 apnea, obstructive sleep 30.9 CRP INS
2 hyperinsulinism 29.7 ABCC8 INS KCNJ11 KCNJ5
3 diabetes mellitus 27.1 ABCC8 CRP GCG INS KCNJ11 PIK3R1
4 diabetes mellitus, noninsulin-dependent 25.5 ABCC8 CRP GCG INS KCNJ11 PIK3R1
5 intellectual deficit buenos-aires type 12.2
6 mental retardation, buenos aires type 12.0
7 ventilation pneumonitis 11.8
8 pneumothorax, primary spontaneous 11.4
9 respiratory failure 11.3
10 bronchitis 11.2
11 allergic rhinitis 11.2
12 pneumonia 11.2
13 lung disease 11.2
14 interstitial lung disease 11.2
15 asthma 11.2
16 pneumothorax 11.1
17 sick building syndrome 11.1
18 pulmonary disease, chronic obstructive 11.1
19 autoimmune polyendocrine syndrome type 1 11.1
20 bronchiectasis 11.1
21 lymphangioleiomyomatosis 11.1
22 q fever 11.1
23 autoimmune retinopathy 11.1
24 bronchiolitis 11.0
25 influenza 11.0
26 sleep apnea 11.0
27 sinusitis 11.0
28 pneumocystosis 11.0
29 pulmonary edema 11.0
30 acute respiratory distress syndrome 10.9
31 tracheoesophageal fistula 10.9
32 panbronchiolitis, diffuse 10.9
33 porphyria, acute hepatic 10.9
34 pollen allergy 10.9
35 legionnaires' disease 10.9
36 coccidioidomycosis 10.9
37 plague 10.9
38 measles 10.9
39 acute mountain sickness 10.9
40 laryngocele 10.9
41 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 10.9
42 mastoiditis 10.9
43 pleural disease 10.9
44 emphysema, congenital lobar 10.9
45 cryptogenic organizing pneumonia 10.9
46 infantile apnea 10.9
47 alkaptonuria 10.8
48 pulmonary alveolar microlithiasis 10.8
49 mycobacterium tuberculosis 1 10.8
50 tracheal disease 10.8

Graphical network of the top 20 diseases related to Acute Insulin Response:



Diseases related to Acute Insulin Response

Symptoms & Phenotypes for Acute Insulin Response

Clinical features from OMIM:

601676

GenomeRNAi Phenotypes related to Acute Insulin Response according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 9.13 INS PIK3R1 TCF7L2
2 Reduced mammosphere formation GR00396-S 9.1 ABCC8 KCNJ11 KCNJ5 PIK3R1 PYGM UCP2

MGI Mouse Phenotypes related to Acute Insulin Response:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.73 ADRB2 INS KCNJ11 PIK3R1 TCF7L2 UCP1
2 cardiovascular system MP:0005385 9.7 ADRB2 CRP INS KCNJ11 KCNJ5 PIK3R1
3 homeostasis/metabolism MP:0005376 9.65 KCNJ11 PIK3R1 PYGM TCF7L2 UCP1 UCP2
4 muscle MP:0005369 9.1 ADRB2 INS KCNJ11 PIK3R1 PYGM TCF7L2

Drugs & Therapeutics for Acute Insulin Response

Drugs for Acute Insulin Response (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 160)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Liraglutide Approved Phase 4 204656-20-2 44147092
2
Pioglitazone Approved, Investigational Phase 4,Not Applicable 111025-46-8 4829
3
Clozapine Approved Phase 4 5786-21-0 2818
4
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 185243-69-0
5
Rosiglitazone Approved, Investigational Phase 4 122320-73-4 77999
6
Protein C Approved Phase 4
7
Menadione Approved, Nutraceutical Phase 4 58-27-5 4055
8
Phytonadione Approved, Investigational, Nutraceutical Phase 4 84-80-0 4812 5284607
9
Serine Approved, Nutraceutical Phase 4 56-45-1 5951
10
Menatetrenone Investigational Phase 4 863-61-6 5282367
11 insulin Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
12 Hormone Antagonists Phase 4,Phase 2,Phase 1,Not Applicable
13 Hormones Phase 4,Phase 2,Phase 1,Not Applicable
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 1,Not Applicable
15 Hypoglycemic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
16 Incretins Phase 4,Phase 2,Phase 1,Not Applicable
17 Insulin, Globin Zinc Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
18 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
19
protease inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
20 Central Nervous System Depressants Phase 4,Not Applicable
21 Micronutrients Phase 4,Not Applicable
22 GABA Agents Phase 4
23 Serotonin Agents Phase 4
24 Serotonin Antagonists Phase 4
25 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
26 Sitagliptin Phosphate Phase 4,Phase 2,Not Applicable
27 Coagulants Phase 4,Not Applicable
28 Glucagon-Like Peptide 1 Phase 4,Not Applicable
29 Neurotransmitter Agents Phase 4
30 Hemostatics Phase 4
31 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1
32 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
33 Trace Elements Phase 4,Not Applicable
34 Tranquilizing Agents Phase 4
35 Dipeptidyl-Peptidase IV Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
36 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
37 Vitamin K 2 Phase 4
38 Vitamin MK 7 Phase 4
39 Vitamins Phase 4
40 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Antifibrinolytic Agents Phase 4
42 Liver Extracts Phase 4,Phase 2,Phase 1,Not Applicable
43 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Antipsychotic Agents Phase 4
45 Psychotropic Drugs Phase 4
46 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Phase 1
47 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
48 Serine Proteinase Inhibitors Phase 4
49 Alpha 1-Antitrypsin Phase 4
50 Trypsin Inhibitors Phase 4

Interventional clinical trials:

(show all 46)
# Name Status NCT ID Phase Drugs
1 Effect of Liraglutide Combined With Short-term CSII on Long-term Glycemic Remission and β Cell Function Unknown status NCT01790308 Phase 4 CSII;Liraglutide
2 Beta-cell Function in Glucose Abnormalities and Acute Myocardial Infarction Completed NCT00627744 Phase 4 Sitagliptin
3 Rosiglitazone for Clozapine Induced Glucose Metabolism Impairment Completed NCT00337350 Phase 4 rosiglitazone;placebo
4 The Effect of Vitamin K Supplementation on Glucose Metabolism Completed NCT00960973 Phase 4 Menatetrenone;Placebo
5 Pioglitazone Incretin Study Completed NCT00656864 Phase 4 Pioglitazone;Placebo
6 Anti-inflammatory Therapy to Improve Outcomes After TPIAT Recruiting NCT02713997 Phase 4 etanercept;Alpha 1-Antitrypsin
7 Liraglutide Actions on the Liver: Effects on Glucose Phosphorylation Not yet recruiting NCT02198209 Phase 4 Liraglutide
8 Study to Evaluate the Effects of Colesevelam on Insulin Sensitivity and ß-Cell Function in Subjects With Impaired Fasting Glucose (Prediabetes) Completed NCT00990184 Phase 3 Colesevelam
9 A Study to Evaluate the Effects of Vildagliptin on the Insulin Response to Glucose in Subjects With Pre-diabetes Completed NCT00312130 Phase 3 Vildagliptin
10 Diet and Medical Therapy Versus Bariatric Surgery in Type 2 Diabetes Completed NCT00888836 Phase 2, Phase 3
11 Islet Transplantation in Type 1 Diabetes Completed NCT00434811 Phase 3 Sirolimus;Tacrolimus
12 Incretin Effect and Use After Clinical Islet Transplantation Completed NCT00768651 Phase 2 Pantoprazole;Sitagliptin
13 Peritransplant Deoxyspergualin in Islet Transplantation in Type 1 Diabetes Completed NCT00434850 Phase 2 Deoxyspergualin;Sirolimus;Tacrolimus
14 Safety and Effectiveness of Low Molecular Weight Sulfated Dextran in Islet Transplantation Completed NCT00789308 Phase 2 Low Molecular Weight Sulfated Dextran (LMW-SD);Heparin;CellCept® (Mycophenolate mofetil) OR Rapamune® (Sirolimus);Prograf® (Tacrolimus) OR Cyclosporine;Thymoglobulin® (Anti-thymocyte Globulin) - at first transplant;Simulect® (Basiliximab) - at 2nd or 3rd transplant;Klexane® (Enoxaparinsodium);Trombyl® or Albyl-E® (Acetylsalicylicacid- ASA);Enbrel® (Etanercept)
15 LEA29Y (Belatacept) Emory Edmonton Protocol Completed NCT00468403 Phase 2 Mycophenolate Mofetil;Tacrolimus
16 To Compare the Effect of a Subcutaneous Canakinumab Administration to Placebo in Patients With Impaired Glucose Tolerance or Patients With Type 2 Diabetes With Differing Baseline Diabetes Therapies Completed NCT01068860 Phase 2 Canakinumab 150 mg;Placebo to Canakinumab
17 Evaluation of the Efficacy of Intramuscular Islet Autograft After Extensive Pancreatectomy Recruiting NCT02872571 Phase 1, Phase 2 Intramuscular Islet Autograft
18 Omental Islet Transplant Active, not recruiting NCT02821026 Phase 1, Phase 2 Anti-Thymocyte Globulin;Mycophenolate mofetil;Tacrolimus;Etanercept;Sirolimus
19 Exenatide and Weight Loss for Diabetes Prevention Completed NCT02084654 Phase 1 Exenatide 5 and 10 mcg 2 times a day;placebo
20 Islet Allotransplantation in Type 1 Diabetes Enrolling by invitation NCT01705899 Phase 1 Human Pancreatic Islets
21 Effects of Short-term Intensive Insulin Therapy in Newly Diagnosed Type 2 Diabetes Patients Unknown status NCT01588743 Not Applicable insulin aspart
22 Changes in Glucose Metabolism After Roux-en-Y Gastric Bypass Unknown status NCT01993511
23 Effect of Exenatide, Sitagliptin or Glimepiride on Functional ß -Cell Mass Completed NCT00775684 Not Applicable Exenatide;Sitagliptin;Glimepiride
24 Sucralose Effects on Glucose Metabolism and Gut Microbiota Completed NCT02650947 Not Applicable
25 Nutrigenomics of Zinc Supplementation in Insulin Secretion and Diabetes Completed NCT00981448 Not Applicable
26 Characterization of the Incretinpathy in Type 2 Diabetes Initiated After Sixty Years Old Completed NCT00843232
27 The Aging Endocrine Pancreas: Characterization of the Entero-insular Axis Physiology in the Elderly Completed NCT00843479
28 Restoration of Beta Cell Function and Cardiovascular Parameters in Relation to Adipoinsular and Enteroinsular Axes After Gastric Bypass Surgery Completed NCT01271062 Not Applicable
29 Long Term Metabolic Safety of Norditropin® Treatment of Small for Gestational Age (SGA) Subjects Completed NCT00787878 somatropin;No treatment given;No treatment given
30 Aldosterone and Glucose Homeostasis Completed NCT00732160 Not Applicable Aldosterone infusion (A);Vehicle Infusion (V)
31 Role of Pancreatic Triglyceride Content in Beta-cell Function Completed NCT00602953
32 Effect of Sitagliptin on Short-Term Metabolic Dysregulation of Oral Glucocorticoid Therapy Completed NCT01488279 Not Applicable Dexamethasone 2.5 mg and Sitagliptin 100 mg;Dexamethasone 2.5 mg and placebo tablet
33 Effect of Different Interventions on Glycemic Control and β-cell Function in Newly Diagnosed Type 2 Diabetic Patients Completed NCT01147627 Not Applicable exenatide injection;Mixed Protamine Zinc Recombinant Human Insulin Lispro 25R;Pioglitazone
34 Effects of Continuous Positive Airway Pressure (CPAP) on Glucose Metabolism Completed NCT01503164 Not Applicable
35 Chromium Picolinate for the Treatment of Metabolic Syndrome Completed NCT00128154 Not Applicable Chromium picolinate
36 Sleep Loss and Mechanisms of Impaired Glucose Metabolism Completed NCT00555750 Not Applicable eszopiclone;placebo
37 Oral Contraceptives, Insulin Resistance and Cardiovascular Risk Profile in Pre-Menopausal Women Completed NCT01475513 Ortho Cyclen®
38 Effects of Corn and Coconut Oils on Lipoprotein Lipids, Insulin Sensitivity and Inflammation Completed NCT03202654 Not Applicable
39 Epigenetic Regulation of Human Adipose Tissue Distribution Recruiting NCT02728635 Not Applicable
40 Effect of Egg Consumption on Cardiometabolic Health in Prediabetic Subjects. Recruiting NCT03332927 Not Applicable
41 Pathogenesis of Youth Onset Type 2 Diabetes and Prediabetes Recruiting NCT03195400
42 MicroRNA as Biomarkers for Development of Metabolic Syndrome in Women With Polycystic Ovary Syndrome Recruiting NCT03142633
43 Effects of Progressive Negative Energy Balance on Glucose Tolerance, Insulin Sensitivity, and Beta-cell Function Active, not recruiting NCT03264001 Not Applicable
44 Effect of Dietary Glycemic Index on Beta-cell Function Active, not recruiting NCT01386645 Not Applicable high glycemic index diet plus N-acetylcysteine
45 Lean Beef Consumption and Insulin Sensitivity in Men and Women With Risk Factors for Diabetes Active, not recruiting NCT03202680 Not Applicable
46 Characterization of Diabetes Mellitus in Fibrous Dysplasia/McCune-Albright Syndrome Not yet recruiting NCT03520153

Search NIH Clinical Center for Acute Insulin Response

Genetic Tests for Acute Insulin Response

Anatomical Context for Acute Insulin Response

MalaCards organs/tissues related to Acute Insulin Response:

41
Liver, Pancreatic Islet, Ovary, Pancreas, Testes

Publications for Acute Insulin Response

Articles related to Acute Insulin Response:

(show top 50) (show all 66)
# Title Authors Year
1
Decline in the Acute Insulin Response in Relationship to Plasma Glucose Concentrations. ( 28948712 )
2017
2
PKA Enhances the Acute Insulin Response Leading to the Restoration of Glucose Control. ( 25475437 )
2015
3
Sitagliptin Improves the Impaired Acute Insulin Response during a Meal Tolerance Test in Japanese Patients with Type 2 Diabetes Mellitus: A Small-Scale Real-World Study. ( 24888256 )
2014
4
Pubertal changes of insulin sensitivity, acute insulin response, and I^-cell function in overweight Latino youth. ( 20888012 )
2011
5
Higher acute insulin response to glucose may determine greater free fatty acid clearance in African-American women. ( 21593106 )
2011
6
A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS FS). ( 19430760 )
2009
7
Childhood predictors of adult acute insulin response and insulin action. ( 19228868 )
2009
8
Uncoupling protein 2 Ala55Val polymorphism is associated with a higher acute insulin response to glucose. ( 19368944 )
2009
9
The interaction between impaired acute insulin response and insulin resistance predict type 2 diabetes and impairment of fasting glucose. ( 18509807 )
2008
10
Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans. ( 17971425 )
2008
11
Absence of an acute insulin response predicts onset of type 2 diabetes in a Caucasian population with impaired glucose tolerance. ( 18460558 )
2008
12
The impact of metabolic syndrome on insulin sensitivity, glucose sensitivity, and acute insulin response after glucose load in early-onset type 2 diabetes mellitus: Taiwan Early-Onset Type 2 Diabetes Cohort Study. ( 18940402 )
2008
13
Acute insulin response to arginine in deceased donors predicts the outcome of human islet isolation. ( 18261179 )
2008
14
Association of the Kir6.2 E23K variant with reduced acute insulin response in African-Americans. ( 18796522 )
2008
15
Restoration of acute insulin response in T2DM subjects 1 month after biliopancreatic diversion. ( 18223616 )
2008
16
Acute insulin response is an independent predictor of type 2 diabetes mellitus in individuals with both normal fasting and 2-h plasma glucose concentrations. ( 17001619 )
2007
17
The uncoupling protein 1 gene, UCP1, is expressed in mammalian islet cells and associated with acute insulin response to glucose in African American families from the IRAS Family Study. ( 17397545 )
2007
18
Acute insulin response and beta-cell compensation in normal subjects treated with olanzapine or risperidone for 2 weeks: response to Hardy et al. ( 17596492 )
2007
19
Acute insulin responses to glucose and arginine as predictors of beta-cell secretory capacity in human islet transplantation. ( 18049122 )
2007
20
Acute insulin response and beta-cell compensation in normal subjects treated with olanzapine or risperidone for 2 weeks. ( 17192353 )
2007
21
Genetic mapping of disposition index and acute insulin response loci on chromosome 11q. The Insulin Resistance Atherosclerosis Study (IRAS) Family Study. ( 16567510 )
2006
22
The insulin sensitivity, glucose sensitivity, and acute insulin response to glucose load in adolescent type 2 diabetes in Taiwanese. ( 15880384 )
2006
23
Acute insulin response (AIR): review of protocols and clinical interest in islet transplantation. ( 16977256 )
2006
24
Acute insulin response of donors is correlated with pancreatic islet isolation outcome in the pig. ( 16132955 )
2005
25
Independent association of insulin resistance with larger amounts of intermuscular adipose tissue and a greater acute insulin response to glucose in African American than in white nondiabetic women. ( 16332653 )
2005
26
Suppression of body weight gain preserves acute insulin response to glucose in the portal vein of spontaneously type 2 diabetic rats with visceral obesity. ( 15888925 )
2005
27
The effect of testosterone supplement on insulin sensitivity, glucose effectiveness, and acute insulin response after glucose load in male type 2 diabetics. ( 16353672 )
2005
28
Genotype Gly/Gly of the Arg16Gly polymorphism of the beta2-adrenergic receptor is associated with elevated fasting serum insulin concentrations, but not with acute insulin response to glucose, in type 2 diabetic patients. ( 14693408 )
2004
29
Preoperative evaluation of infants with focal or diffuse congenital hyperinsulinism by intravenous acute insulin response tests and selective pancreatic arterial calcium stimulation. ( 14715863 )
2004
30
The insulin sensitivity, glucose effectiveness and acute insulin response to glucose load of non-obese adolescent type 2 diabetes. ( 15536022 )
2004
31
Acute insulin responses to calcium and tolbutamide do not differentiate focal from diffuse congenital hyperinsulinism. ( 14764815 )
2004
32
The effect of surgical stress on insulin sensitivity, glucose effectiveness and acute insulin response to glucose load. ( 12906365 )
2003
33
Restoration of euglycemia and normal acute insulin response to glucose in obese subjects with type 2 diabetes following bariatric surgery. ( 12716738 )
2003
34
Elevated plasma nonesterified fatty acids are associated with deterioration of acute insulin response in IGT but not NGT. ( 12582008 )
2003
35
Proinsulin and acute insulin response independently predict Type 2 diabetes mellitus in men--report from 27 years of follow-up study. ( 12637978 )
2003
36
Acute insulin response tests for the differential diagnosis of congenital hyperinsulinism. ( 12364426 )
2002
37
Increased proinsulin levels and decreased acute insulin response independently predict the incidence of type 2 diabetes in the insulin resistance atherosclerosis study. ( 11916954 )
2002
38
Acute insulin responses to leucine in children with the hyperinsulinism/hyperammonemia syndrome. ( 11502802 )
2001
39
Relationship between acute insulin response and vitamin K intake in healthy young male volunteers. ( 10517305 )
1999
40
The relation of proinsulin and insulin to insulin sensitivity and acute insulin response in subjects with newly diagnosed type II diabetes: the Insulin Resistance Atherosclerosis Study. ( 10447516 )
1999
41
Acute insulin response to intravenous arginine in nonobese healthy cats. ( 10587254 )
1999
42
Both a reduced acute insulin response to glucose and lower glucose effectiveness are responsible for the worsening of intravenous glucose tolerance in healthy subjects independently of the degree of obesity. ( 9500569 )
1998
43
Acute insulin response to intravenous glucagon in polycystic ovary syndrome. ( 9619535 )
1998
44
Lowering fatty acids potentiates acute insulin response in first degree relatives of people with type II diabetes. ( 9794097 )
1998
45
Variant in the regulatory subunit of phosphatidylinositol 3-kinase (p85alpha): preliminary evidence indicates a potential role of this variant in the acute insulin response and type 2 diabetes in Pima women. ( 9604878 )
1998
46
A physical map at 1p31 encompassing the acute insulin response locus and the leptin receptor. ( 9027510 )
1997
47
The relation of proinsulin, insulin, and proinsulin-to-insulin ratio to insulin sensitivity and acute insulin response in normoglycemic subjects. ( 9392485 )
1997
48
Insulin sensitivity and acute insulin response in African-Americans, non-Hispanic whites, and Hispanics with NIDDM: the Insulin Resistance Atherosclerosis Study. ( 8971083 )
1997
49
Insulin sensitivity index, acute insulin response, and glucose effectiveness in a population-based sample of 380 young healthy Caucasians. Analysis of the impact of gender, body fat, physical fitness, and life-style factors. ( 8787683 )
1996
50
Comparison of the minimal model and the hyperglycemic clamp for measuring insulin sensitivity and acute insulin response to glucose. ( 7666784 )
1995

Variations for Acute Insulin Response

Expression for Acute Insulin Response

Search GEO for disease gene expression data for Acute Insulin Response.

Pathways for Acute Insulin Response

Pathways related to Acute Insulin Response according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.56 ABCC8 ADRB2 GCG INS KCNJ11 KCNJ5
2 12.22 GCG INS UCP1 UCP2
3
Show member pathways
12.07 ABCC8 GCG INS KCNJ11
4
Show member pathways
11.96 GCG INS TCF7L2
5
Show member pathways
11.86 ABCC8 KCNJ11 KCNJ5
6
Show member pathways
11.71 ABCC8 KCNJ11 KCNJ5
7
Show member pathways
11.67 INS PIK3R1 PYGM
8
Show member pathways
11.54 ABCC8 INS KCNJ11 PIK3R1
9 11.28 ADRB2 INS PIK3R1
10 11.21 ABCC8 KCNJ11 PIK3R1
11 11.1 INS PIK3R1
12 11 ABCC8 ADRB2 KCNJ11 KCNJ5
13
Show member pathways
10.67 UCP1 UCP2
14 10.57 ABCC8 INS KCNJ11 UCP2

GO Terms for Acute Insulin Response

Cellular components related to Acute Insulin Response according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inward rectifying potassium channel GO:0008282 8.62 ABCC8 KCNJ11

Biological processes related to Acute Insulin Response according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.84 GCG INS PIK3R1 UCP2
2 positive regulation of protein kinase B signaling GO:0051897 9.67 INS PIK3R1 TCF7L2
3 potassium ion transport GO:0006813 9.65 ABCC8 KCNJ11 KCNJ5
4 acute-phase response GO:0006953 9.55 CRP INS
5 positive regulation of glucose import GO:0046326 9.52 INS PIK3R1
6 brown fat cell differentiation GO:0050873 9.51 ADRB2 UCP1
7 response to glucose GO:0009749 9.5 INS TCF7L2 UCP2
8 positive regulation of glucose import in response to insulin stimulus GO:2001275 9.46 INS PIK3R1
9 regulation of protein localization to plasma membrane GO:1903076 9.43 INS PIK3R1
10 negative regulation of blood vessel diameter GO:0097756 9.4 CRP INS
11 diet induced thermogenesis GO:0002024 9.37 ADRB2 UCP1
12 regulation of insulin secretion GO:0050796 9.33 ABCC8 GCG KCNJ11
13 adaptive thermogenesis GO:1990845 9.26 UCP1 UCP2
14 response to cold GO:0009409 9.13 ADRB2 UCP1 UCP2
15 mitochondrial transmembrane transport GO:1990542 8.62 UCP1 UCP2

Molecular functions related to Acute Insulin Response according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor binding GO:0005158 9.32 INS PIK3R1
2 inward rectifier potassium channel activity GO:0005242 9.26 KCNJ11 KCNJ5
3 insulin-like growth factor receptor binding GO:0005159 9.16 INS PIK3R1
4 ATP-activated inward rectifier potassium channel activity GO:0015272 8.96 ABCC8 KCNJ11
5 oxidative phosphorylation uncoupler activity GO:0017077 8.62 UCP1 UCP2

Sources for Acute Insulin Response

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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