AIR
MCID: ACT088
MIFTS: 48

Acute Insulin Response (AIR)

Aliases & Classifications for Acute Insulin Response

MalaCards integrated aliases for Acute Insulin Response:

Name: Acute Insulin Response 57 13
Air 57 3

External Ids:

OMIM 57 601676

Summaries for Acute Insulin Response

CDC : 3 Outdoor air quality has improved since the 1990s, but many challenges remain in protecting Americans from air quality problems. Ground-level ozone, the main part of smog, and particle pollution are just two of the many threats to air quality and public health in the United States.

MalaCards based summary : Acute Insulin Response, also known as air, is related to apnea, obstructive sleep and hyperinsulinism. An important gene associated with Acute Insulin Response is AIR (Acute Insulin Response (2)), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Glucose / Energy Metabolism. The drugs Liraglutide and Zinc have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and liver, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and Reduced mammosphere formation

Description from OMIM: 601676

Related Diseases for Acute Insulin Response

Diseases related to Acute Insulin Response via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 852)
# Related Disease Score Top Affiliating Genes
1 apnea, obstructive sleep 31.7 CRP INS
2 hyperinsulinism 30.0 ABCC8 INS KCNJ11 KCNJ5
3 gestational diabetes 29.7 INS KCNJ11 TCF7L2
4 dumping syndrome 29.2 GCG INS
5 gastrointestinal system disease 29.1 CRP GCG INS
6 hypoglycemia 29.0 ABCC8 GCG INS KCNJ11
7 diabetes mellitus 29.0 ABCC8 CRP GCG INS KCNJ11 PIK3R1
8 diabetes mellitus, noninsulin-dependent 28.5 UCP2 UCP1 TCF7L2 PIK3R1 KCNJ11 INS
9 intellectual deficit buenos-aires type 12.3
10 mental retardation, buenos aires type 12.2
11 ventilation pneumonitis 11.9
12 pneumothorax, primary spontaneous 11.6
13 respiratory failure 11.4
14 allergic rhinitis 11.4
15 lung disease 11.4
16 bronchitis 11.4
17 pneumonia 11.4
18 interstitial lung disease 11.3
19 asthma 11.3
20 pneumothorax 11.3
21 pulmonary disease, chronic obstructive 11.3
22 sick building syndrome 11.3
23 streptococcal group a invasive disease 11.3
24 bronchiectasis 11.3
25 autoimmune polyendocrine syndrome type 1 11.3
26 lymphangioleiomyomatosis 11.3
27 mycobacterium tuberculosis 1 11.2
28 pulmonary alveolar microlithiasis 11.2
29 q fever 11.2
30 autoimmune retinopathy 11.2
31 chikungunya 11.2
32 bronchiolitis 11.2
33 pollen allergy 11.1
34 legionnaires' disease 11.1
35 influenza 11.1
36 sleep apnea 11.1
37 acute respiratory distress syndrome 11.1
38 tracheoesophageal fistula 11.1
39 sinusitis 11.1
40 pulmonary edema 11.1
41 measles 11.1
42 pneumocystosis 11.1
43 meniere disease 11.1
44 coccidioidomycosis 11.1
45 plague 11.1
46 mouth disease 11.1
47 panbronchiolitis, diffuse 11.1
48 porphyria, acute hepatic 11.1
49 dengue disease 11.1
50 tracheomalacia 11.1

Graphical network of the top 20 diseases related to Acute Insulin Response:



Diseases related to Acute Insulin Response

Symptoms & Phenotypes for Acute Insulin Response

Clinical features from OMIM:

601676

GenomeRNAi Phenotypes related to Acute Insulin Response according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 9.13 INS PIK3R1 TCF7L2
2 Reduced mammosphere formation GR00396-S 9.1 ABCC8 KCNJ11 KCNJ5 PIK3R1 PYGM UCP2

MGI Mouse Phenotypes related to Acute Insulin Response:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.73 ADRB2 INS KCNJ11 PIK3R1 TCF7L2 UCP1
2 cardiovascular system MP:0005385 9.7 ADRB2 CRP INS KCNJ11 KCNJ5 PIK3R1
3 homeostasis/metabolism MP:0005376 9.65 ABCC8 ADRB2 CRP INS KCNJ11 PIK3R1
4 muscle MP:0005369 9.1 ADRB2 INS KCNJ11 PIK3R1 PYGM TCF7L2

Drugs & Therapeutics for Acute Insulin Response

Drugs for Acute Insulin Response (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 171)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Liraglutide Approved Phase 4 204656-20-2 44147092
2
Zinc Approved, Investigational Phase 4,Phase 2,Not Applicable 7440-66-6
3
Clozapine Approved Phase 4 5786-21-0 2818
4
Rosiglitazone Approved, Investigational Phase 4 122320-73-4 77999
5
Phytonadione Approved, Investigational Phase 4 84-80-0 4812 5284607
6
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
7
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
8
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
9
Polyestradiol phosphate Approved Phase 4 28014-46-2
10
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
11 Estradiol valerate Approved, Investigational, Vet_approved Phase 4 979-32-8
12
Pioglitazone Approved, Investigational Phase 4,Not Applicable 111025-46-8 4829
13
Protein C Approved Phase 4
14
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 185243-69-0
15
Menadione Approved, Nutraceutical Phase 4 58-27-5 4055
16
Serine Approved, Nutraceutical Phase 4 56-45-1 5951
17
Menatetrenone Investigational Phase 4 863-61-6 5282367
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 1,Not Applicable
19 Hypoglycemic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
20 Hormones Phase 4,Phase 2,Phase 1,Not Applicable
21 Insulin, Globin Zinc Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
22 Hormone Antagonists Phase 4,Phase 2,Phase 1,Not Applicable
23 insulin Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
24 Incretins Phase 4,Phase 2,Phase 1,Not Applicable
25 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
26
protease inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
27 Dipeptidyl-Peptidase IV Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
28 Sitagliptin Phosphate Phase 4,Phase 2,Not Applicable
29 Liver Extracts Phase 4,Phase 1,Phase 2,Not Applicable
30 Glucagon-Like Peptide 1 Phase 4,Not Applicable
31 Serotonin Agents Phase 4
32 GABA Agents Phase 4
33 Antipsychotic Agents Phase 4
34 Central Nervous System Depressants Phase 4,Not Applicable
35 Psychotropic Drugs Phase 4
36 Tranquilizing Agents Phase 4
37 Serotonin Antagonists Phase 4
38 Neurotransmitter Agents Phase 4
39 Micronutrients Phase 4,Not Applicable
40 Menaquinone Phase 4
41 Vitamin K Phase 4
42 Coagulants Phase 4,Not Applicable
43 Antifibrinolytic Agents Phase 4
44 naphthoquinone Phase 4
45 Vitamin K 2 Phase 4
46 Vitamin MK 7 Phase 4
47 Vitamins Phase 4
48 Trace Elements Phase 4,Not Applicable
49 Hemostatics Phase 4
50 Estrogens Phase 4

Interventional clinical trials:

(show all 47)
# Name Status NCT ID Phase Drugs
1 Effect of Liraglutide Combined With Short-term CSII on Long-term Glycemic Remission and β Cell Function Unknown status NCT01790308 Phase 4 CSII;Liraglutide
2 Beta-cell Function in Glucose Abnormalities and Acute Myocardial Infarction Completed NCT00627744 Phase 4 Sitagliptin
3 Liraglutide Actions on the Liver: Effects on Glucose Phosphorylation Not yet recruiting NCT02198209 Phase 4 Liraglutide
4 Rosiglitazone for Clozapine Induced Glucose Metabolism Impairment Completed NCT00337350 Phase 4 rosiglitazone;placebo
5 The Effect of Vitamin K Supplementation on Glucose Metabolism Completed NCT00960973 Phase 4 Menatetrenone;Placebo
6 Oral Contraceptives, Insulin Resistance and Cardiovascular Risk Profile in Pre-Menopausal Women Completed NCT01475513 Phase 4 Ortho Cyclen®
7 Pioglitazone Incretin Study Completed NCT00656864 Phase 4 Pioglitazone;Placebo
8 Anti-inflammatory Therapy to Improve Outcomes After TPIAT Recruiting NCT02713997 Phase 4 etanercept;Alpha 1-Antitrypsin
9 Study to Evaluate the Effects of Colesevelam on Insulin Sensitivity and ß-Cell Function in Subjects With Impaired Fasting Glucose (Prediabetes) Completed NCT00990184 Phase 3 Colesevelam
10 A Study to Evaluate the Effects of Vildagliptin on the Insulin Response to Glucose in Subjects With Pre-diabetes Completed NCT00312130 Phase 3 Vildagliptin
11 Diet and Medical Therapy Versus Bariatric Surgery in Type 2 Diabetes Completed NCT00888836 Phase 2, Phase 3
12 Islet Transplantation in Type 1 Diabetes Completed NCT00434811 Phase 3 Sirolimus;Tacrolimus
13 Evaluation of the Efficacy of Intramuscular Islet Autograft After Extensive Pancreatectomy Recruiting NCT02872571 Phase 1, Phase 2 Intramuscular Islet Autograft
14 Incretin Effect and Use After Clinical Islet Transplantation Completed NCT00768651 Phase 2 Pantoprazole;Sitagliptin
15 Evaluation of Superiority of Valsartan+Celecoxib+Metformin Over Metformin Alone in Type 2 Diabetes Patients Not yet recruiting NCT03686657 Phase 1, Phase 2 Metformin;Val, Cel and Met XR Low;Val, Cel and Met XR High
16 Omental Islet Transplant Active, not recruiting NCT02821026 Phase 1, Phase 2 Anti-Thymocyte Globulin;Mycophenolate mofetil;Tacrolimus;Etanercept;Sirolimus
17 Peritransplant Deoxyspergualin in Islet Transplantation in Type 1 Diabetes Completed NCT00434850 Phase 2 Deoxyspergualin;Sirolimus;Tacrolimus
18 Safety and Effectiveness of Low Molecular Weight Sulfated Dextran in Islet Transplantation Completed NCT00789308 Phase 2 Low Molecular Weight Sulfated Dextran (LMW-SD);Heparin;CellCept® (Mycophenolate mofetil) OR Rapamune® (Sirolimus);Prograf® (Tacrolimus) OR Cyclosporine;Thymoglobulin® (Anti-thymocyte Globulin) - at first transplant;Simulect® (Basiliximab) - at 2nd or 3rd transplant;Klexane® (Enoxaparinsodium);Trombyl® or Albyl-E® (Acetylsalicylicacid- ASA);Enbrel® (Etanercept)
19 LEA29Y (Belatacept) Emory Edmonton Protocol Completed NCT00468403 Phase 2 Mycophenolate Mofetil;Tacrolimus
20 To Compare the Effect of a Subcutaneous Canakinumab Administration to Placebo in Patients With Impaired Glucose Tolerance or Patients With Type 2 Diabetes With Differing Baseline Diabetes Therapies Completed NCT01068860 Phase 2 Canakinumab 150 mg;Placebo to Canakinumab
21 Exenatide and Weight Loss for Diabetes Prevention Completed NCT02084654 Phase 1 Exenatide 5 and 10 mcg 2 times a day;placebo
22 Islet Allotransplantation in Type 1 Diabetes Enrolling by invitation NCT01705899 Phase 1 Human Pancreatic Islets
23 Effects of Short-term Intensive Insulin Therapy in Newly Diagnosed Type 2 Diabetes Patients Unknown status NCT01588743 Not Applicable insulin aspart
24 Changes in Glucose Metabolism After Roux-en-Y Gastric Bypass Unknown status NCT01993511
25 Effect of Exenatide, Sitagliptin or Glimepiride on Functional ß -Cell Mass Completed NCT00775684 Not Applicable Exenatide;Sitagliptin;Glimepiride
26 Effects of Progressive Negative Energy Balance on Glucose Tolerance, Insulin Sensitivity, and Beta-cell Function Active, not recruiting NCT03264001 Not Applicable
27 Sucralose Effects on Glucose Metabolism and Gut Microbiota Completed NCT02650947 Not Applicable
28 Nutrigenomics of Zinc Supplementation in Insulin Secretion and Diabetes Completed NCT00981448 Not Applicable
29 Characterization of the Incretinpathy in Type 2 Diabetes Initiated After Sixty Years Old Completed NCT00843232
30 The Aging Endocrine Pancreas: Characterization of the Entero-insular Axis Physiology in the Elderly Completed NCT00843479
31 Restoration of Beta Cell Function and Cardiovascular Parameters in Relation to Adipoinsular and Enteroinsular Axes After Gastric Bypass Surgery Completed NCT01271062 Not Applicable
32 Long Term Metabolic Safety of Norditropin® Treatment of Small for Gestational Age (SGA) Subjects Completed NCT00787878 somatropin;No treatment given;No treatment given
33 Aldosterone and Glucose Homeostasis Completed NCT00732160 Not Applicable Aldosterone infusion (A);Vehicle Infusion (V)
34 Role of Pancreatic Triglyceride Content in Beta-cell Function Completed NCT00602953
35 Effect of Dietary Glycemic Index on Beta-cell Function Active, not recruiting NCT01386645 Not Applicable high glycemic index diet plus N-acetylcysteine
36 Effect of Sitagliptin on Short-Term Metabolic Dysregulation of Oral Glucocorticoid Therapy Completed NCT01488279 Not Applicable Dexamethasone 2.5 mg and Sitagliptin 100 mg;Dexamethasone 2.5 mg and placebo tablet
37 Effect of Different Interventions on Glycemic Control and β-cell Function in Newly Diagnosed Type 2 Diabetic Patients Completed NCT01147627 Not Applicable exenatide injection;Mixed Protamine Zinc Recombinant Human Insulin Lispro 25R;Pioglitazone
38 Effects of Continuous Positive Airway Pressure (CPAP) on Glucose Metabolism Completed NCT01503164 Not Applicable
39 Epigenetic Regulation of Human Adipose Tissue Distribution Recruiting NCT02728635 Not Applicable
40 Chromium Picolinate for the Treatment of Metabolic Syndrome Completed NCT00128154 Not Applicable Chromium picolinate
41 Sleep Loss and Mechanisms of Impaired Glucose Metabolism Completed NCT00555750 Not Applicable eszopiclone;placebo
42 Characterization of Diabetes Mellitus in Fibrous Dysplasia/McCune-Albright Syndrome Recruiting NCT03520153
43 Effect of Egg Consumption on Cardiometabolic Health in Prediabetic Subjects. Recruiting NCT03332927 Not Applicable
44 Lean Beef Consumption and Insulin Sensitivity in Men and Women With Risk Factors for Diabetes Active, not recruiting NCT03202680 Not Applicable
45 Pathogenesis of Youth Onset Type 2 Diabetes and Prediabetes Recruiting NCT03195400
46 MicroRNA as Biomarkers for Development of Metabolic Syndrome in Women With Polycystic Ovary Syndrome Recruiting NCT03142633
47 Effects of Corn and Coconut Oils on Lipoprotein Lipids, Insulin Sensitivity and Inflammation Completed NCT03202654 Not Applicable

Search NIH Clinical Center for Acute Insulin Response

Genetic Tests for Acute Insulin Response

Anatomical Context for Acute Insulin Response

MalaCards organs/tissues related to Acute Insulin Response:

41
Lung, Testes, Liver, Brain, Pancreatic Islet, Heart, Pancreas

Publications for Acute Insulin Response

Articles related to Acute Insulin Response:

(show top 50) (show all 1062)
# Title Authors Year
1
Is residential ambient air limonene associated with asthma? Findings from the Canadian Health Measures Survey. ( 30469291 )
2019
2
Air pollution in relation to very short-term risk of ST-segment elevation myocardial infarction: Case-crossover analysis of SWEDEHEART. ( 30509372 )
2019
3
The association between short-term ambient air pollution and daily outpatient visits for schizophrenia: A hospital-based study. ( 30326384 )
2019
4
The impact of air pollutant deposition on solar energy system efficiency: An approach to estimate PV soiling effects with the Community Multiscale Air Quality (CMAQ) model. ( 30243165 )
2019
5
From "Secret Preparation" to "Vitalized Air": Doctored Nitrous Oxide. ( 30550430 )
2019
6
Laryngeal mask airway as a rescue device for failed endotracheal intubation during scene-to-hospital air transport of combat casualties. ( 30557236 )
2019
7
Learning to Air-Breathe: The First Steps. ( 30540236 )
2019
8
Bio-based and photocrosslinked electrospun antibacterial nanofibrous membranes for air filtration. ( 30446139 )
2019
9
Sintering Behavior of Copper Nanoparticle Ink by Laser in Air. ( 30469173 )
2019
10
Maternal exposure to short-to medium-term outdoor air pollution and obstetric and neonatal outcomes: A systematic review. ( 30469286 )
2019
11
Prenatal particulate air pollution exposure and cord blood homocysteine in newborns: Results from the ENVIRONAGE birth cohort. ( 30477822 )
2019
12
Preparation from Lepidium meyenii Walpers using high-speed countercurrent chromatography and thermal stability of macamides in air at various temperatures. ( 30481640 )
2019
13
Cross-task cue utilisation and situational awareness in simulated air traffic control. ( 30487105 )
2019
14
Profile of inhalable bacteria in PM2.5 at Mt. Tai, China: Abundance, community, and influence of air mass trajectories. ( 30384158 )
2019
15
Effects of various warming patterns on Cd transfer in soil-rice systems under Free Air Temperature Increase (FATI) conditions. ( 30384170 )
2019
16
Metal organic frameworks as potent treatment media for odorants and volatiles in air. ( 30384228 )
2019
17
Source apportionment of polycyclic aromatic hydrocarbons (PAHs) in the air of Dalian, China: Correlations with six criteria air pollutants and meteorological conditions. ( 30388687 )
2019
18
Improved performance Air bio-battery based on efficient oxygen supply with a gas/liquid highly-porous diaphragm cell. ( 30391786 )
2019
19
Association between ambient air pollution and Parkinson's disease: Systematic review and meta-analysis. ( 30391837 )
2019
20
Association of short-term exposure to ambient air pollutants with exhaled nitric oxide in hospitalized patients with respiratory-system diseases. ( 30396136 )
2019
21
Characteristics of pea, lentil and faba bean starches isolated from air-classified flours in comparison with commercial starches. ( 30409638 )
2019
22
Evaluation of the 2016 ENV57 MetroERM measurement comparison on 137Cs, 134Cs and 131I in air filters. ( 30412865 )
2019
23
Time series analysis of ambient air-temperature during the period 1970-2016 over Sydney, Australia. ( 30340306 )
2019
24
Investigating the potential for transisomerisation of trycresyl phosphate with a palladium catalyst and its implications for aircraft cabin air quality. ( 30342398 )
2019
25
Molecular simulations of COFs, IRMOFs and ZIFs for adsorption-based separation of carbon tetrachloride from air. ( 30342419 )
2019
26
Increasing risk of congenital anomalies associated with seasonal pattern of air pollution: Differences by maternal comorbidities. ( 30343146 )
2019
27
Evaluating a multi-panel air cathode through electrochemical and biotic tests. ( 30343198 )
2019
28
Organophosphate esters in biota, water, and air from an agricultural area of Chongqing, western China: Concentrations, composition profiles, partition and human exposure. ( 30352353 )
2019
29
Seasonal variation, air-water exchange, and multivariate source apportionment of polycyclic aromatic hydrocarbons in the coastal area of Dalian, China. ( 30352355 )
2019
30
Development of an in-home, real-time air pollutant sensor platform and implications for community use. ( 30359926 )
2019
31
Investigation of Composite Nano Air Filter for Improving Antimicrobial Activity and Reducing VOCs Using a High Speed Upward Electrospinning System. ( 30360144 )
2019
32
The aggravation of urban air quality deterioration due to urbanization, transportation and economic development - Panel models with marginal effect analyses across China. ( 30360243 )
2019
33
Effects of ambient air pollution on daily hospital admissions for respiratory and cardiovascular diseases in Bangkok, Thailand. ( 30360246 )
2019
34
Cryogenic circulation for indoor air pollution control. ( 30360274 )
2019
35
Determination of PCB fluxes from Indiana Harbor and Ship Canal using dual-deployed air and water passive samplers. ( 30366294 )
2019
36
Easy and inexpensive method for the visual and electronic detection of oxidants in air by using vinylic films with embedded aniline. ( 30368061 )
2019
37
Imaging the air-water interface: Characterising biomimetic and natural hydrophobic surfaces using in situ atomic force microscopy. ( 30380435 )
2019
38
Air pollution and telomere length in adults: A systematic review and meta-analysis of observational studies. ( 30384069 )
2019
39
Exploring atmospheric stagnation during a severe particulate matter air pollution episode over complex terrain in Santiago, Chile. ( 30384076 )
2019
40
Measuring and mapping the effectiveness of the European Air Quality Directive in reducing N and S deposition at the ecosystem level. ( 30282327 )
2019
41
Transparent thermoplastic polyurethane air filters for efficient electrostatic capture of particulate matter pollutants. ( 30284536 )
2019
42
The effect of force applied to the left paratracheal oesophagus on air entry into the gastric antrum during positive-pressure ventilation using a facemask. ( 30288741 )
2019
43
Determination of six veterinary pharmaceuticals in egg by liquid chromatography: Chemometric optimization of a novel air assisted-dispersive liquid-liquid microextraction by solid floating organic drop. ( 30292368 )
2019
44
Soil microbial community structure in the rhizosphere of Robinia pseudoacacia L. seedlings exposed to elevated air temperature and cadmium-contaminated soils for 4 years. ( 30292991 )
2019
45
Ambient air pollution and fetal growth restriction: Physician diagnosis of fetal growth restriction versus population-based small-for-gestational age. ( 30296771 )
2019
46
Comparative evaluation of spoilage-related bacterial diversity and metabolite profiles in chilled beef stored under air and vacuum packaging. ( 30297047 )
2019
47
Evaluation of volatile organic compounds coupled to seasonality effects in indoor air from a commercial office in Madrid (Spain) applying chemometric techniques. ( 30308861 )
2019
48
Spatiotemporal impact of soil moisture on air temperature across the Tibet Plateau. ( 30308904 )
2019
49
CFD modelling of air quality in Pamplona City (Spain): Assessment, stations spatial representativeness and health impacts valuation. ( 30308906 )
2019
50
Air quality index induced nonsmooth system for respiratory infection. ( 30312690 )
2019

Variations for Acute Insulin Response

Expression for Acute Insulin Response

Search GEO for disease gene expression data for Acute Insulin Response.

Pathways for Acute Insulin Response

Pathways related to Acute Insulin Response according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.31 ABCC8 ADRB2 GCG INS KCNJ11 KCNJ5
2 12.22 GCG INS UCP1 UCP2
3
Show member pathways
12.07 ABCC8 GCG INS KCNJ11
4
Show member pathways
11.96 GCG INS TCF7L2
5
Show member pathways
11.86 ABCC8 KCNJ11 KCNJ5
6
Show member pathways
11.71 ABCC8 KCNJ11 KCNJ5
7
Show member pathways
11.67 INS PIK3R1 PYGM
8
Show member pathways
11.54 ABCC8 INS KCNJ11 PIK3R1
9 11.28 ADRB2 INS PIK3R1
10 11.21 ABCC8 KCNJ11 PIK3R1
11 11.1 INS PIK3R1
12 11 ABCC8 ADRB2 KCNJ11 KCNJ5
13
Show member pathways
10.67 UCP1 UCP2
14 10.57 ABCC8 INS KCNJ11 UCP2

GO Terms for Acute Insulin Response

Cellular components related to Acute Insulin Response according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inward rectifying potassium channel GO:0008282 8.62 ABCC8 KCNJ11

Biological processes related to Acute Insulin Response according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase B signaling GO:0051897 9.7 INS PIK3R1 TCF7L2
2 potassium ion transport GO:0006813 9.69 ABCC8 KCNJ11 KCNJ5
3 acute-phase response GO:0006953 9.58 CRP INS
4 positive regulation of cold-induced thermogenesis GO:0120162 9.58 ADRB2 UCP1 UCP2
5 potassium ion import GO:0010107 9.57 KCNJ11 KCNJ5
6 positive regulation of glucose import GO:0046326 9.56 INS PIK3R1
7 negative regulation of insulin secretion GO:0046676 9.55 ABCC8 KCNJ11
8 brown fat cell differentiation GO:0050873 9.54 ADRB2 UCP1
9 positive regulation of glucose import in response to insulin stimulus GO:2001275 9.49 INS PIK3R1
10 mitochondrial transport GO:0006839 9.48 UCP1 UCP2
11 cellular glucose homeostasis GO:0001678 9.46 ABCC8 PIK3R1
12 regulation of protein localization to plasma membrane GO:1903076 9.43 INS PIK3R1
13 negative regulation of blood vessel diameter GO:0097756 9.37 CRP INS
14 regulation of insulin secretion GO:0050796 9.33 ABCC8 GCG KCNJ11
15 adaptive thermogenesis GO:1990845 9.32 UCP1 UCP2
16 diet induced thermogenesis GO:0002024 9.26 ADRB2 UCP1
17 mitochondrial transmembrane transport GO:1990542 8.96 UCP1 UCP2
18 response to cold GO:0009409 8.8 ADRB2 UCP1 UCP2

Molecular functions related to Acute Insulin Response according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor binding GO:0005158 9.32 INS PIK3R1
2 inward rectifier potassium channel activity GO:0005242 9.26 KCNJ11 KCNJ5
3 insulin-like growth factor receptor binding GO:0005159 9.16 INS PIK3R1
4 ATP-activated inward rectifier potassium channel activity GO:0015272 8.96 ABCC8 KCNJ11
5 oxidative phosphorylation uncoupler activity GO:0017077 8.62 UCP1 UCP2

Sources for Acute Insulin Response

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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