AIR
MCID: ACT088
MIFTS: 39

Acute Insulin Response (AIR)

Aliases & Classifications for Acute Insulin Response

MalaCards integrated aliases for Acute Insulin Response:

Name: Acute Insulin Response 57 13
Air 57

External Ids:

OMIM® 57 601676

Summaries for Acute Insulin Response

MalaCards based summary : Acute Insulin Response, also known as air, is related to apnea, obstructive sleep and decubitus ulcer. An important gene associated with Acute Insulin Response is AIR (Acute Insulin Response (2)), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Glucose / Energy Metabolism. The drugs Exenatide and Hormones have been mentioned in the context of this disorder. Affiliated tissues include ovary, liver and pancreas, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and Reduced mammosphere formation

More information from OMIM: 601676

Related Diseases for Acute Insulin Response

Diseases related to Acute Insulin Response via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1683)
# Related Disease Score Top Affiliating Genes
1 apnea, obstructive sleep 31.2 INS GCG CRP
2 decubitus ulcer 30.7 INS CRP
3 newborn respiratory distress syndrome 30.3 CRP ABCC8
4 mediastinitis 30.2 INS CRP
5 congestive heart failure 30.1 INS CRP ADRB2 ABCC8
6 dumping syndrome 30.1 INS GCG
7 hyperglycemia 30.0 KCNJ11 INS GCG ABCC8
8 mucormycosis 30.0 INS CRP
9 hyperinsulinemic hypoglycemia, familial, 2 30.0 KCNJ11 INS ABCC8
10 sleep disorder 29.9 INS GCG CRP
11 aspiration pneumonia 29.9 INS CRP
12 hypoglycemia 29.8 KCNJ11 INS GCG ABCC8
13 cavernous sinus thrombosis 29.8 INS CRP
14 meckel diverticulum 29.8 GCG CRP
15 chronic ulcer of skin 29.8 INS CRP
16 volvulus of midgut 29.8 GCG CRP
17 lactose intolerance 29.8 INS CRP
18 lipid metabolism disorder 29.7 TCF7L2 INS CRP
19 dysthymic disorder 29.7 INS CRP
20 drug allergy 29.7 INS CRP
21 pancreatitis 29.6 INS GCG CRP
22 diabetes mellitus, ketosis-prone 29.6 KCNJ11 INS GCG ABCC8
23 gestational diabetes 29.6 TCF7L2 KCNJ11 INS GCG CRP ABCC8
24 paralytic ileus 29.6 INS CRP
25 constipation 29.6 INS GCG CRP
26 pyelitis 29.6 INS CRP
27 suppurative thyroiditis 29.5 INS CRP
28 asphyxia neonatorum 29.5 KCNJ11 INS CRP ABCC8
29 chronic kidney disease 29.5 UCP2 INS GCG CRP
30 non-alcoholic fatty liver disease 29.4 UCP2 INS GCG CRP
31 coronary artery vasospasm 29.4 KCNJ11 CRP ABCC8
32 leptin deficiency or dysfunction 29.4 UCP1 INS GCG CRP
33 hyperinsulinism 29.3 UCP2 KCNJ5 KCNJ11 INS GCG ABCC8
34 lipoprotein quantitative trait locus 29.2 KCNJ5 INS GCG CRP ADRB2
35 prediabetes syndrome 29.2 UCP2 TCF7L2 INS GCG CRP
36 heart disease 29.0 UCP2 KCNJ5 KCNJ11 INS GCG CRP
37 glucose metabolism disease 28.7 KCNJ11 INS GCG CRP ABCC8
38 celiac disease 1 28.7 INS GCG CRP
39 glucose intolerance 28.7 UCP2 TCF7L2 KCNJ11 INS GCG CRP
40 overnutrition 28.6 UCP2 UCP1 INS GCG CRP
41 hypertension, essential 28.0 UCP2 UCP1 KCNJ5 KCNJ11 INS GCG
42 body mass index quantitative trait locus 11 28.0 UCP2 UCP1 TCF7L2 PIK3R1 KCNJ11 INS
43 type 2 diabetes mellitus 27.6 UCP2 UCP1 TCF7L2 PIK3R1 KCNJ5 KCNJ11
44 diabetes mellitus 27.1 UCP2 UCP1 TCF7L2 PIK3R1 KCNJ5 KCNJ11
45 pulmonary disease, chronic obstructive 11.5
46 ventilation pneumonitis 11.4
47 pneumothorax, primary spontaneous 11.3
48 surfactant dysfunction 11.2
49 pneumothorax 11.2
50 bronchitis 11.2

Graphical network of the top 20 diseases related to Acute Insulin Response:



Diseases related to Acute Insulin Response

Symptoms & Phenotypes for Acute Insulin Response

Clinical features from OMIM®:

601676 (Updated 05-Mar-2021)

GenomeRNAi Phenotypes related to Acute Insulin Response according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 9.13 INS PIK3R1 TCF7L2
2 Reduced mammosphere formation GR00396-S 9.1 ABCC8 KCNJ11 KCNJ5 PIK3R1 PYGM UCP2

MGI Mouse Phenotypes related to Acute Insulin Response:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.73 ADRB2 INS KCNJ11 PIK3R1 TCF7L2 UCP1
2 endocrine/exocrine gland MP:0005379 9.7 ABCC8 ADRB2 INS KCNJ11 PIK3R1 TCF7L2
3 homeostasis/metabolism MP:0005376 9.65 ABCC8 ADRB2 CRP INS KCNJ11 PIK3R1
4 muscle MP:0005369 9.1 ADRB2 INS KCNJ11 PIK3R1 PYGM TCF7L2

Drugs & Therapeutics for Acute Insulin Response

Drugs for Acute Insulin Response (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Exenatide Approved, Investigational Phase 1 141758-74-9 15991534
2 Hormones Phase 1
3 Anti-Obesity Agents Phase 1
4 Hormone Antagonists Phase 1
5 Hypoglycemic Agents Phase 1
6 Incretins Phase 1
7 Insulin, Globin Zinc
8 insulin
9 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Trial Investigating Exenatide for Diabetes Prevention in Obese, Insulin-Resistant Individuals With Prediabetes Completed NCT02084654 Phase 1 Exenatide 5 and 10 mcg 2 times a day;placebo
2 Epigenetic Regulation of Human Adipose Tissue Distribution Active, not recruiting NCT02728635

Search NIH Clinical Center for Acute Insulin Response

Genetic Tests for Acute Insulin Response

Anatomical Context for Acute Insulin Response

MalaCards organs/tissues related to Acute Insulin Response:

40
Ovary, Liver, Pancreas, Pancreatic Islet, Endothelial, Bone, Adipocyte

Publications for Acute Insulin Response

Articles related to Acute Insulin Response:

(show top 50) (show all 777)
# Title Authors PMID Year
1
A physical map at 1p31 encompassing the acute insulin response locus and the leptin receptor. 57 61
9027510 1997
2
Evidence for linkage between a region on chromosome 1p and the acute insulin response in Pima Indians. 57 61
7698519 1995
3
Lower insulin clearance is associated with increased risk of type 2 diabetes in Native Americans. 61
33404681 2021
4
Pancreatic fat accumulation is associated with decreased β-cell function and deterioration in glucose tolerance in Korean adults. 61
33258260 2020
5
Associations of GlycA and high-sensitivity C-reactive protein with measures of lipolysis in adults with obesity. 61
32863171 2020
6
Effects of resistant starch on glycaemic control: a systematic review and meta-analysis. 61
32959735 2020
7
Longitudinal Study on Metabolic Health in Adults SGA During 5 Years After GH With or Without 2 Years of GnRHa Treatment. 61
32436961 2020
8
Different β-cell secretory phenotype in non-obese compared to obese early type 2 diabetes. 61
32017362 2020
9
Adipocyte Insulin Resistance in PCOS: Relationship With GLUT-4 Expression and Whole-Body Glucose Disposal and β-Cell Function. 61
32382742 2020
10
Long-term Metabolic and Socioeducational Outcomes of Transient Neonatal Diabetes: A Longitudinal and Cross-sectional Study. 61
32273272 2020
11
The Impact of Obesity On Insulin Sensitivity and Secretion During Pubertal Progression: A Longitudinal Study. 61
31996919 2020
12
Trafficking of nonesterified fatty acids in insulin resistance and relationship to dysglycemia. 61
31910030 2020
13
Decreased Plasma Maresin 1 Concentration Is Associated with Diabetic Foot Ulcer. 61
32377160 2020
14
The effects of dietary nitrate on plasma glucose and insulin sensitivity in sheep. 61
31418937 2019
15
Dose-Dependent Effects of Exercise and Diet on Insulin Sensitivity and Secretion. 61
31033904 2019
16
Sex Differences in Effects of Obesity on Reproductive Hormones and Glucose Metabolism in Early Puberty. 61
30985874 2019
17
Utility of arginine stimulation testing in preoperative assessment of children undergoing total pancreatectomy with islet autotransplantation. 61
31230395 2019
18
Conjugated Estrogens and Bazedoxifene Improve β Cell Function in Obese Menopausal Women. 61
31384719 2019
19
Recent evidence for the effects of nonnutritive sweeteners on glycaemic control. 61
31033578 2019
20
Mitochondrial mutation m.3243A>G associates with insulin resistance in non-diabetic carriers. 61
31146262 2019
21
Adipose Insulin Resistance in Normal-Weight Women With Polycystic Ovary Syndrome. 61
30649347 2019
22
Oral Glucose Tolerance Testing Allows Better Prediction of Diabetes in Women with a History of Gestational Diabetes Mellitus. 61
30604595 2019
23
Two nights of recovery sleep restores the dynamic lipemic response, but not the reduction of insulin sensitivity, induced by five nights of sleep restriction. 61
30892916 2019
24
Insulin Sensitivity Is Associated with Lipoprotein Lipase (LPL) and Catenin Delta 2 (CTNND2) DNA Methylation in Peripheral White Blood Cells in Non-Diabetic Young Women. 61
31208038 2019
25
Predictors of Long-Term Glycemic Remission After 2-Week Intensive Insulin Treatment in Newly Diagnosed Type 2 Diabetes. 61
30629195 2019
26
Effects of dietary fat on insulin secretion in subjects with the metabolic syndrome. 61
30893645 2019
27
Adipocyte expression of glucose transporter 1 and 4 in PCOS: Relationship to insulin-mediated and non-insulin-mediated whole-body glucose uptake. 61
30623452 2019
28
Insulin function in obese children within the low and high ranges of impaired fasting glycemia. 61
30537059 2019
29
Pathogenic Mechanisms of Prediabetes in Obese vs. Very Obese African American Women: Implications for Diabetes Prevention. 61
30032866 2019
30
Postprandial Insulin Response and Clearance Among Black and White Women: The Federal Women's Study. 61
30260396 2019
31
Disposition Index in Active Acromegaly. 61
31620090 2019
32
Effects of medium chain triglycerides supplementation on insulin sensitivity and beta cell function: A feasibility study. 61
31869355 2019
33
Risk of diabetes associated with fatty acids in the de novo lipogenesis pathway is independent of insulin sensitivity and response: the Insulin Resistance Atherosclerosis Study (IRAS). 61
31543975 2019
34
Decreased VMAT2 in the pancreas of humans with type 2 diabetes mellitus measured in vivo by PET imaging. 61
29721633 2018
35
Effects of overconditioning on pancreatic insulin secretory capacity, fat infiltration, and the number and size of islets in dairy cows at the end of the dry period. 61
30316589 2018
36
Effects of sucralose on insulin and glucagon-like peptide-1 secretion in healthy subjects: a randomized, double-blind, placebo-controlled trial. 61
30005329 2018
37
Sucralose decreases insulin sensitivity in healthy subjects: a randomized controlled trial. 61
30535090 2018
38
Effects of age and diet on glucose and insulin dynamics in the horse. 61
29356053 2018
39
Genome-wide interaction with the insulin secretion locus MTNR1B reveals CMIP as a novel type 2 diabetes susceptibility gene in African Americans. 61
29691896 2018
40
Relationship between serum adipsin and the first phase of glucose-stimulated insulin secretion in individuals with different glucose tolerance. 61
29432659 2018
41
Contribution of parasympathetic muscarinic augmentation of insulin secretion to olanzapine-induced hyperinsulinemia. 61
29351487 2018
42
Pathophysiological Characteristics Underlying Different Glucose Response Curves: A Latent Class Trajectory Analysis From the Prospective EGIR-RISC Study. 61
29853473 2018
43
Lower mean blood glucose during short-term intensive insulin therapy is associated with long-term glycemic remission in patients with newly diagnosed type 2 diabetes: Evidence-based recommendations for standardization. 61
29193795 2018
44
Fimasartan increases glucose-stimulated insulin secretion in patients with type 2 diabetes and hypertension compared with amlodipine. 61
29546730 2018
45
Outpatient versus inpatient mixed meal tolerance and arginine stimulation testing yields comparable measures of variability for assessment of beta cell function. 61
30023442 2018
46
Sequential Treatment Escalation with Dapagliflozin and Saxagliptin Improves Beta Cell Function in Type 2 Diabetic Patients on Previous Metformin Treatment: An Exploratory Mechanistic Study. 61
29727906 2018
47
Prospective evaluation of insulin and incretin dynamics in obese adults with and without diabetes for 2 years after Roux-en-Y gastric bypass. 61
29428999 2018
48
Endothelial dysfunction of coronary arteries in subjects without diabetes: An association with both insulin resistance and impaired insulin secretion response. 61
29526680 2018
49
Metabolomics Identifies Distinctive Metabolite Signatures for Measures of Glucose Homeostasis: The Insulin Resistance Atherosclerosis Family Study (IRAS-FS). 61
29546329 2018
50
Pioglitazone Improved Insulin Sensitivity and First Phase Insulin Secretion Among Obese and Lean People with Diabetes: A Multicenter Clamp Study. 61
29536426 2018

Variations for Acute Insulin Response

Expression for Acute Insulin Response

Search GEO for disease gene expression data for Acute Insulin Response.

Pathways for Acute Insulin Response

Pathways related to Acute Insulin Response according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.5 TCF7L2 KCNJ5 KCNJ11 INS GCG ABCC8
2 12.25 UCP2 UCP1 INS GCG
3
Show member pathways
12.07 KCNJ11 INS GCG ABCC8
4
Show member pathways
11.97 TCF7L2 INS GCG
5
Show member pathways
11.87 KCNJ5 KCNJ11 ABCC8
6
Show member pathways
11.73 KCNJ5 KCNJ11 ABCC8
7
Show member pathways
11.69 PYGM PIK3R1 INS
8
Show member pathways
11.44 PIK3R1 KCNJ11 INS ABCC8
9 11.42 PIK3R1 KCNJ5 KCNJ11
10 11.3 PIK3R1 INS ADRB2
11 11.21 PIK3R1 KCNJ11 ABCC8
12 11 KCNJ5 KCNJ11 ADRB2 ABCC8
13
Show member pathways
10.69 UCP2 UCP1
14 10.57 UCP2 KCNJ11 INS ABCC8

GO Terms for Acute Insulin Response

Cellular components related to Acute Insulin Response according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inward rectifying potassium channel GO:0008282 8.62 KCNJ11 ABCC8

Biological processes related to Acute Insulin Response according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase B signaling GO:0051897 9.72 TCF7L2 PIK3R1 INS
2 potassium ion transport GO:0006813 9.65 KCNJ5 KCNJ11 ABCC8
3 potassium ion transmembrane transport GO:0071805 9.63 KCNJ5 KCNJ11 ABCC8
4 glucose homeostasis GO:0042593 9.58 TCF7L2 INS GCG
5 negative regulation of insulin secretion GO:0046676 9.57 KCNJ11 ABCC8
6 cellular response to hormone stimulus GO:0032870 9.56 UCP2 UCP1
7 brown fat cell differentiation GO:0050873 9.54 UCP1 ADRB2
8 mitochondrial transport GO:0006839 9.52 UCP2 UCP1
9 cellular glucose homeostasis GO:0001678 9.51 PIK3R1 ABCC8
10 positive regulation of cold-induced thermogenesis GO:0120162 9.5 UCP2 UCP1 ADRB2
11 regulation of protein localization to plasma membrane GO:1903076 9.49 PIK3R1 INS
12 inorganic cation transmembrane transport GO:0098662 9.43 KCNJ11 ABCC8
13 diet induced thermogenesis GO:0002024 9.37 UCP1 ADRB2
14 adaptive thermogenesis GO:1990845 9.26 UCP2 UCP1
15 mitochondrial transmembrane transport GO:1990542 9.16 UCP2 UCP1
16 regulation of insulin secretion GO:0050796 9.13 KCNJ11 GCG ABCC8
17 response to cold GO:0009409 8.8 UCP2 UCP1 ADRB2

Molecular functions related to Acute Insulin Response according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor binding GO:0005158 9.37 PIK3R1 INS
2 inward rectifier potassium channel activity GO:0005242 9.32 KCNJ5 KCNJ11
3 insulin-like growth factor receptor binding GO:0005159 9.26 PIK3R1 INS
4 cation-transporting ATPase activity GO:0019829 9.16 KCNJ11 ABCC8
5 ATP-activated inward rectifier potassium channel activity GO:0015272 8.96 KCNJ11 ABCC8
6 oxidative phosphorylation uncoupler activity GO:0017077 8.62 UCP2 UCP1

Sources for Acute Insulin Response

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....