Aliases & Classifications for Acute Insulin Response

MalaCards integrated aliases for Acute Insulin Response:

Name: Acute Insulin Response 58 13
Air 58 3

External Ids:

OMIM 58 601676

Summaries for Acute Insulin Response

CDC : 3 Outdoor air quality has improved since the 1990s, but many challenges remain in protecting Americans from air quality problems. Ground-level ozone, the main part of smog, and particle pollution are just two of the many threats to air quality and public health in the United States.

MalaCards based summary : Acute Insulin Response, also known as air, is related to apnea, obstructive sleep and hyperinsulinism. An important gene associated with Acute Insulin Response is AIR (Acute Insulin Response (2)), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Glucose / Energy Metabolism. The drugs Liraglutide and Zinc have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and bone, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and Reduced mammosphere formation

Description from OMIM: 601676

Related Diseases for Acute Insulin Response

Diseases related to Acute Insulin Response via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1026)
# Related Disease Score Top Affiliating Genes
1 apnea, obstructive sleep 31.7 CRP INS
2 hyperinsulinism 30.0 ABCC8 INS KCNJ11 KCNJ5
3 gestational diabetes 29.6 INS KCNJ11 TCF7L2
4 glucose intolerance 29.4 CRP GCG INS
5 hypoglycemia 29.3 ABCC8 GCG INS KCNJ11
6 dumping syndrome 29.3 GCG INS
7 gastrointestinal system disease 29.0 CRP GCG INS
8 diabetes mellitus 28.4 ABCC8 CRP GCG INS KCNJ11 PIK3R1
9 body mass index quantitative trait locus 11 27.8 ADRB2 CRP GCG INS PIK3R1 UCP1
10 diabetes mellitus, noninsulin-dependent 27.7 ABCC8 CRP GCG INS KCNJ11 PIK3R1
11 intellectual deficit buenos-aires type 12.4
12 mental retardation, buenos aires type 12.2
13 ventilation pneumonitis 12.0
14 pneumothorax, primary spontaneous 11.6
15 respiratory failure 11.6
16 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 11.5
17 lung disease 11.4
18 pulmonary disease, chronic obstructive 11.4
19 bronchitis 11.4
20 allergic rhinitis 11.4
21 pneumonia 11.4
22 asthma 11.4
23 interstitial lung disease 11.4
24 cryptogenic organizing pneumonia 11.4
25 pneumothorax 11.4
26 streptococcal group a invasive disease 11.3
27 sick building syndrome 11.3
28 autoimmune polyendocrine syndrome type 1 11.3
29 mycobacterium tuberculosis 1 11.3
30 bronchiectasis 11.3
31 pulmonary alveolar microlithiasis 11.3
32 q fever 11.3
33 lymphangioleiomyomatosis 11.3
34 chikungunya 11.3
35 autoimmune retinopathy 11.3
36 bronchiolitis 11.2
37 legionnaires' disease 11.2
38 influenza 11.2
39 pollen allergy 11.2
40 pulmonary edema 11.2
41 acute respiratory distress syndrome 11.2
42 sleep apnea 11.2
43 meniere disease 11.2
44 sinusitis 11.2
45 mouth disease 11.2
46 tracheoesophageal fistula 11.2
47 mucormycosis 11.2
48 palatopharyngeal incompetence 11.1
49 pneumocystosis 11.1
50 patulous eustachian tube 11.1

Graphical network of the top 20 diseases related to Acute Insulin Response:



Diseases related to Acute Insulin Response

Symptoms & Phenotypes for Acute Insulin Response

Clinical features from OMIM:

601676

GenomeRNAi Phenotypes related to Acute Insulin Response according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 9.13 INS PIK3R1 TCF7L2
2 Reduced mammosphere formation GR00396-S 9.1 ABCC8 KCNJ11 KCNJ5 PIK3R1 PYGM UCP2

MGI Mouse Phenotypes related to Acute Insulin Response:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.73 ADRB2 INS KCNJ11 PIK3R1 TCF7L2 UCP1
2 cardiovascular system MP:0005385 9.7 ADRB2 CRP INS KCNJ11 KCNJ5 PIK3R1
3 homeostasis/metabolism MP:0005376 9.65 ABCC8 ADRB2 CRP INS KCNJ11 PIK3R1
4 muscle MP:0005369 9.1 ADRB2 INS KCNJ11 PIK3R1 PYGM TCF7L2

Drugs & Therapeutics for Acute Insulin Response

Drugs for Acute Insulin Response (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 173)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Liraglutide Approved Phase 4 204656-20-2 44147092
2
Zinc Approved, Investigational Phase 4,Phase 2,Not Applicable 7440-66-6 32051
3
Clozapine Approved Phase 4 5786-21-0 2818
4
Rosiglitazone Approved, Investigational Phase 4 122320-73-4 77999
5 Menaquinone Approved, Investigational Phase 4 1182-68-9
6
Phylloquinone Approved, Investigational Phase 4 84-80-0
7
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
8
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
9
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
10
Polyestradiol phosphate Approved Phase 4 28014-46-2
11
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
12
Pioglitazone Approved, Investigational Phase 4,Not Applicable 111025-46-8 4829
13
Protein C Approved Phase 4
14
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 185243-69-0
15
Menadione Approved, Nutraceutical Phase 4 58-27-5 4055
16
Serine Approved, Nutraceutical Phase 4 56-45-1 5951
17
Menatetrenone Investigational Phase 4 863-61-6 5282367
18 Hormones Phase 4,Phase 2,Phase 1,Not Applicable
19 Incretins Phase 4,Phase 2,Phase 1,Not Applicable
20 Insulin, Globin Zinc Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
21 insulin Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
22 Hormone Antagonists Phase 4,Phase 2,Phase 1,Not Applicable
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 1,Not Applicable
24 Hypoglycemic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
25 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
26
protease inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
27 Dipeptidyl-Peptidase IV Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
28 Sitagliptin Phosphate Phase 4,Phase 2,Not Applicable
29 Glucagon-Like Peptide 1 Phase 4,Not Applicable
30 Liver Extracts Phase 4,Phase 1,Phase 2,Not Applicable
31 Tranquilizing Agents Phase 4
32 Central Nervous System Depressants Phase 4,Not Applicable
33 Neurotransmitter Agents Phase 4
34 Serotonin Antagonists Phase 4
35 Psychotropic Drugs Phase 4
36 Serotonin Agents Phase 4
37 Antipsychotic Agents Phase 4
38 GABA Agents Phase 4
39 Vitamins Phase 4
40 Vitamin K Phase 4
41 Hemostatics Phase 4
42 Antifibrinolytic Agents Phase 4
43 Trace Elements Phase 4,Not Applicable
44 Micronutrients Phase 4,Not Applicable
45 Coagulants Phase 4,Not Applicable
46 Vitamin K 2 Phase 4
47 Vitamin MK 7 Phase 4
48 Nutrients Phase 4,Not Applicable
49 naphthoquinone Phase 4
50 Estrogens Phase 4

Interventional clinical trials:

(show all 48)
# Name Status NCT ID Phase Drugs
1 Effect of Liraglutide Combined With Short-term CSII on Long-term Glycemic Remission and β Cell Function Unknown status NCT01790308 Phase 4 CSII;Liraglutide
2 Beta-cell Function in Glucose Abnormalities and Acute Myocardial Infarction Completed NCT00627744 Phase 4 Sitagliptin
3 Liraglutide Actions on the Liver: Effects on Glucose Phosphorylation Not yet recruiting NCT02198209 Phase 4 Liraglutide
4 Rosiglitazone for Clozapine Induced Glucose Metabolism Impairment Completed NCT00337350 Phase 4 rosiglitazone;placebo
5 The Effect of Vitamin K Supplementation on Glucose Metabolism Completed NCT00960973 Phase 4 Menatetrenone;Placebo
6 Oral Contraceptives, Insulin Resistance and Cardiovascular Risk Profile in Pre-Menopausal Women Completed NCT01475513 Phase 4 Ortho Cyclen®
7 Pioglitazone Incretin Study Completed NCT00656864 Phase 4 Pioglitazone;Placebo
8 Anti-inflammatory Therapy to Improve Outcomes After TPIAT Recruiting NCT02713997 Phase 4 etanercept;Alpha 1-Antitrypsin
9 Study to Evaluate the Effects of Colesevelam on Insulin Sensitivity and ß-Cell Function in Subjects With Impaired Fasting Glucose (Prediabetes) Completed NCT00990184 Phase 3 Colesevelam
10 A Study to Evaluate the Effects of Vildagliptin on the Insulin Response to Glucose in Subjects With Pre-diabetes Completed NCT00312130 Phase 3 Vildagliptin
11 Diet and Medical Therapy Versus Bariatric Surgery in Type 2 Diabetes Completed NCT00888836 Phase 2, Phase 3
12 Islet Transplantation in Type 1 Diabetes Completed NCT00434811 Phase 3 Sirolimus;Tacrolimus
13 Evaluation of Superiority of Valsartan+Celecoxib+Metformin Over Metformin Alone in Type 2 Diabetes Patients Not yet recruiting NCT03686657 Phase 1, Phase 2 Metformin;Val, Cel and Met XR Low;Val, Cel and Met XR High
14 Evaluation of the Efficacy of Intramuscular Islet Autograft After Extensive Pancreatectomy Recruiting NCT02872571 Phase 1, Phase 2 Intramuscular Islet Autograft
15 Incretin Effect and Use After Clinical Islet Transplantation Completed NCT00768651 Phase 2 Pantoprazole;Sitagliptin
16 Omental Islet Transplant Active, not recruiting NCT02821026 Phase 1, Phase 2 Anti-Thymocyte Globulin;Mycophenolate mofetil;Tacrolimus;Etanercept;Sirolimus
17 Peritransplant Deoxyspergualin in Islet Transplantation in Type 1 Diabetes Completed NCT00434850 Phase 2 Deoxyspergualin;Sirolimus;Tacrolimus
18 Safety and Effectiveness of Low Molecular Weight Sulfated Dextran in Islet Transplantation Completed NCT00789308 Phase 2 Low Molecular Weight Sulfated Dextran (LMW-SD);Heparin;CellCept® (Mycophenolate mofetil) OR Rapamune® (Sirolimus);Prograf® (Tacrolimus) OR Cyclosporine;Thymoglobulin® (Anti-thymocyte Globulin) - at first transplant;Simulect® (Basiliximab) - at 2nd or 3rd transplant;Klexane® (Enoxaparinsodium);Trombyl® or Albyl-E® (Acetylsalicylicacid- ASA);Enbrel® (Etanercept)
19 LEA29Y (Belatacept) Emory Edmonton Protocol Completed NCT00468403 Phase 2 Mycophenolate Mofetil;Tacrolimus
20 To Compare the Effect of a Subcutaneous Canakinumab Administration to Placebo in Patients With Impaired Glucose Tolerance or Patients With Type 2 Diabetes With Differing Baseline Diabetes Therapies Completed NCT01068860 Phase 2 Canakinumab 150 mg;Placebo to Canakinumab
21 The Effects of LY2409021 on the Liver Completed NCT01588366 Phase 1 Placebo;LY2409021
22 Exenatide and Weight Loss for Diabetes Prevention Completed NCT02084654 Phase 1 Exenatide 5 and 10 mcg 2 times a day;placebo
23 Islet Allotransplantation in Type 1 Diabetes Enrolling by invitation NCT01705899 Phase 1 Human Pancreatic Islets
24 Effects of Short-term Intensive Insulin Therapy in Newly Diagnosed Type 2 Diabetes Patients Unknown status NCT01588743 Not Applicable insulin aspart
25 Changes in Glucose Metabolism After Roux-en-Y Gastric Bypass Unknown status NCT01993511
26 Effect of Exenatide, Sitagliptin or Glimepiride on Functional ß -Cell Mass Completed NCT00775684 Not Applicable Exenatide;Sitagliptin;Glimepiride
27 Effects of Progressive Negative Energy Balance on Glucose Tolerance, Insulin Sensitivity, and Beta-cell Function Active, not recruiting NCT03264001 Not Applicable
28 Sucralose Effects on Glucose Metabolism and Gut Microbiota Completed NCT02650947 Not Applicable
29 Nutrigenomics of Zinc Supplementation in Insulin Secretion and Diabetes Completed NCT00981448 Not Applicable
30 Characterization of the Incretinpathy in Type 2 Diabetes Initiated After Sixty Years Old Completed NCT00843232
31 Restoration of Beta Cell Function and Cardiovascular Parameters in Relation to Adipoinsular and Enteroinsular Axes After Gastric Bypass Surgery Completed NCT01271062 Not Applicable
32 The Aging Endocrine Pancreas: Characterization of the Entero-insular Axis Physiology in the Elderly Completed NCT00843479
33 Long Term Metabolic Safety of Norditropin® Treatment of Small for Gestational Age (SGA) Subjects Completed NCT00787878 somatropin;No treatment given;No treatment given
34 Aldosterone and Glucose Homeostasis Completed NCT00732160 Not Applicable Aldosterone infusion (A);Vehicle Infusion (V)
35 Role of Pancreatic Triglyceride Content in Beta-cell Function Completed NCT00602953
36 Effect of Dietary Glycemic Index on Beta-cell Function Active, not recruiting NCT01386645 Not Applicable high glycemic index diet plus N-acetylcysteine
37 Effect of Sitagliptin on Short-Term Metabolic Dysregulation of Oral Glucocorticoid Therapy Completed NCT01488279 Not Applicable Dexamethasone 2.5 mg and Sitagliptin 100 mg;Dexamethasone 2.5 mg and placebo tablet
38 Effect of Different Interventions on Glycemic Control and β-cell Function in Newly Diagnosed Type 2 Diabetic Patients Completed NCT01147627 Not Applicable exenatide injection;Mixed Protamine Zinc Recombinant Human Insulin Lispro 25R;Pioglitazone
39 Effects of Continuous Positive Airway Pressure (CPAP) on Glucose Metabolism Completed NCT01503164 Not Applicable
40 Epigenetic Regulation of Human Adipose Tissue Distribution Active, not recruiting NCT02728635 Not Applicable
41 Chromium Picolinate for the Treatment of Metabolic Syndrome Completed NCT00128154 Not Applicable Chromium picolinate
42 Sleep Loss and Mechanisms of Impaired Glucose Metabolism Completed NCT00555750 Not Applicable eszopiclone;placebo
43 Characterization of Diabetes Mellitus in Fibrous Dysplasia/McCune-Albright Syndrome Recruiting NCT03520153
44 Effect of Egg Consumption on Cardiometabolic Health in Prediabetic Subjects. Recruiting NCT03332927 Not Applicable
45 Lean Beef Consumption and Insulin Sensitivity in Men and Women With Risk Factors for Diabetes Active, not recruiting NCT03202680 Not Applicable
46 Pathogenesis of Youth Onset Type 2 Diabetes and Prediabetes Recruiting NCT03195400
47 MicroRNA as Biomarkers for Development of Metabolic Syndrome in Women With Polycystic Ovary Syndrome Completed NCT03142633
48 Effects of Corn and Coconut Oils on Lipoprotein Lipids, Insulin Sensitivity and Inflammation Completed NCT03202654 Not Applicable

Search NIH Clinical Center for Acute Insulin Response

Genetic Tests for Acute Insulin Response

Anatomical Context for Acute Insulin Response

MalaCards organs/tissues related to Acute Insulin Response:

42
Lung, Heart, Bone, Brain, Liver, Testes, Breast

Publications for Acute Insulin Response

Articles related to Acute Insulin Response:

(show top 50) (show all 3042)
# Title Authors Year
1
Effect of laminar air flow and building construction on aspergillosis in acute leukemia patients: a retrospective cohort study. ( 30626352 )
2019
2
Comment on "Effect of short-term fluctuations in outdoor air pollution on the number of hospital admissions due to acute myocardial infarction among inhabitants of Kraków, Poland". ( 30816101 )
2019
3
Effect of short-term fluctuations in outdoor air pollution on the number of hospital admissions due to acute myocardial infarction among inhabitants of Kraków, Poland. ( 30688288 )
2019
4
Low to Moderate Air Pollutant Exposure and Acute Respiratory Distress Syndrome after Severe Trauma. ( 30067389 )
2019
5
Could the Air You Breathe Increase Your Risk of Developing Acute Respiratory Distress Syndrome? ( 30133313 )
2019
6
Spread through air spaces is an independent predictor of recurrence in stage III (N2) lung adenocarcinoma. ( 31106332 )
2019
7
Limited Resection is Associated With a Higher Risk of Locoregional Recurrence than Lobectomy in Stage I Lung Adenocarcinoma With Tumor Spread Through Air Spaces. ( 31107717 )
2019
8
Air Pollution and Adenocarcinoma in Never-Smokers. ( 31027739 )
2019
9
Spread through air spaces in lung adenocarcinoma: is radiology reliable yet? ( 30997191 )
2019
10
Prognostic Impact of Tumor Spread Through Air Spaces in Sublobar Resection for 1A Lung Adenocarcinoma Patients. ( 30887374 )
2019
11
An air-containing mediastinal mass in a patient with a primary adenocarcinoma of the right lung. ( 30724708 )
2019
12
Relationship between stromal cells and tumor spread through air spaces in lung adenocarcinoma. ( 30605235 )
2019
13
CT Manifestations of Tumor Spread through Air Spaces in Lung Adenocarcinoma: Different Pathways toward Common Perspectives. ( 30511911 )
2019
14
Lobectomy Is Associated with Better Outcomes than Sublobar Resection in Spread through Air Spaces (STAS)-Positive T1 Lung Adenocarcinoma: A Propensity Score-Matched Analysis. ( 30244070 )
2019
15
A prospective RCT comparing combined chromoendoscopy with water exchange (CWE) vs water exchange (WE) vs air insufflation (AI) in adenoma detection in screening colonoscopy. ( 31065365 )
2019
16
Reduction of multitasking distractions underlies the higher adenoma detection rate of water exchange compared to air insufflation - blinded analysis of withdrawal phase videos. ( 31080608 )
2019
17
Air Pollution and Angioedema. ( 31038389 )
2019
18
Anorexia nervosa presenting as diffuse spontaneous air leaks. ( 30755429 )
2019
19
Pleural anthracosis as an indicator of lifetime exposure to urban air pollution: An autopsy-based study in Sao Paulo. ( 30884435 )
2019
20
Myo-inositol mediates the effects of traffic-related air pollution on generalized anxiety symptoms at age 12 years. ( 31103795 )
2019
21
lifetime exposure to traffic-related air pollution and symptoms of depression and anxiety at age 12 years. ( 30925441 )
2019
22
Association between Exposure to Ambient Air Pollution and Rheumatoid Arthritis in Adults. ( 30959862 )
2019
23
Air Pollution Exposure and Asthma Incidence in Children: Demonstrating the Value of Air Quality Standards. ( 31112243 )
2019
24
Association of Changes in Air Quality With Incident Asthma in Children in California, 1993-2014. ( 31112259 )
2019
25
Indoor Endotoxin Exposure and Ambient Air Pollutants Interact on Asthma Outcomes. ( 31063402 )
2019
26
Can the effects of outdoor air pollution on asthma be mitigated? ( 31029773 )
2019
27
Synergistic Association of House Endotoxin Exposure and Ambient Air Pollution with Asthma Outcomes. ( 30965018 )
2019
28
Perturbations of the arginine metabolome following exposures to traffic-related air pollution in a panel of commuters with and without asthma. ( 30981021 )
2019
29
Omega-3 and Omega-6 Intake Modifies Asthma Severity and Response to Indoor Air Pollution in Children. ( 30922077 )
2019
30
Traffic related air pollution and the burden of childhood asthma in the contiguous United States in 2000 and 2010. ( 30954275 )
2019
31
Air Pollution Contributes to Asthma Deaths. ( 30912954 )
2019
32
The influence of air pollution on respiratory allergies, asthma and wheeze in childhood in Hungary. ( 30916519 )
2019
33
Impact of weather and climate change with indoor and outdoor air quality in asthma. ( 30826366 )
2019
34
18-year evolution of asthma and allergic diseases in French urban schoolchildren in relation to indoor air pollutant levels. ( 30827471 )
2019
35
Compressive Air-trapping in Asthma: Effects of Age, Sex, and Severity. ( 30844338 )
2019
36
Short-Term Exposure to Ambient Air Pollution and Asthma Mortality. ( 30871339 )
2019
37
Neighborhood air pollution and household environmental health as it relates to respiratory health and healthcare utilization among elderly persons with asthma. ( 30810414 )
2019
38
Sources of indoor particulate matter (PM) and outdoor air pollution in China in relation to asthma, wheeze, rhinitis and eczema among pre-school children: Synergistic effects between antibiotics use and PM10 and second hand smoke. ( 30731375 )
2019
39
The Short-Term Effects of Ambient Air Pollutants on Childhood Asthma Hospitalization in Taiwan: A National Study. ( 30642061 )
2019
40
A ubiquitous asthma monitoring framework based on ambient air pollutants and individuals' contexts. ( 30656587 )
2019
41
Is residential ambient air limonene associated with asthma? Findings from the Canadian Health Measures Survey. ( 30469291 )
2019
42
Ambient Air Pollution and Variation in Multiple Domains of Asthma Morbidity among Peruvian Children. ( 30365919 )
2019
43
Changes in the relationship between childhood asthma and ambient air pollution in Taiwan: Results from a nationwide survey repeated 5 years apart. ( 30371957 )
2019
44
Air pollution, urgent asthma medical visits and the modifying effect of neighborhood asthma prevalence. ( 30337671 )
2019
45
Asthma-related outcomes associated with indoor air pollutants among schoolchildren from four informal settlements in two municipalities in the Western Cape Province of South Africa. ( 30339304 )
2019
46
Association between air pollution and asthma exacerbations in Badalona, Barcelona (Spain), 2008-2016. ( 30149947 )
2019
47
Indoor air pollution aggravates asthma in Chinese children and induces the changes in serum level of miR-155. ( 30084260 )
2019
48
Can atrial fibrillation be caused or triggered by air pollution? An epidemiological perspective. ( 30971128 )
2019
49
Association of short- and long-term exposure to air pollution with atrial fibrillation. ( 30862234 )
2019
50
Massive air embolism caused by an atrioesophageal fistula following isolation of the pulmonary veins for atrial fibrillation. ( 30820407 )
2019

Variations for Acute Insulin Response

Expression for Acute Insulin Response

Search GEO for disease gene expression data for Acute Insulin Response.

Pathways for Acute Insulin Response

Pathways related to Acute Insulin Response according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.5 ABCC8 ADRB2 GCG INS KCNJ11 KCNJ5
2 12.22 GCG INS UCP1 UCP2
3
Show member pathways
12.07 ABCC8 GCG INS KCNJ11
4
Show member pathways
11.95 GCG INS TCF7L2
5
Show member pathways
11.84 ABCC8 KCNJ11 KCNJ5
6
Show member pathways
11.71 ABCC8 KCNJ11 KCNJ5
7
Show member pathways
11.67 INS PIK3R1 PYGM
8
Show member pathways
11.54 ABCC8 INS KCNJ11 PIK3R1
9 11.28 ADRB2 INS PIK3R1
10 11.21 ABCC8 KCNJ11 PIK3R1
11 11.09 INS PIK3R1
12 11 ABCC8 ADRB2 KCNJ11 KCNJ5
13 10.57 ABCC8 INS KCNJ11 UCP2

GO Terms for Acute Insulin Response

Cellular components related to Acute Insulin Response according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inward rectifying potassium channel GO:0008282 8.62 ABCC8 KCNJ11

Biological processes related to Acute Insulin Response according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase B signaling GO:0051897 9.69 INS PIK3R1 TCF7L2
2 potassium ion transport GO:0006813 9.67 ABCC8 KCNJ11 KCNJ5
3 positive regulation of cold-induced thermogenesis GO:0120162 9.58 ADRB2 UCP1 UCP2
4 acute-phase response GO:0006953 9.56 CRP INS
5 positive regulation of glucose import GO:0046326 9.55 INS PIK3R1
6 negative regulation of insulin secretion GO:0046676 9.54 ABCC8 KCNJ11
7 brown fat cell differentiation GO:0050873 9.52 ADRB2 UCP1
8 mitochondrial transport GO:0006839 9.48 UCP1 UCP2
9 cellular glucose homeostasis GO:0001678 9.46 ABCC8 PIK3R1
10 regulation of protein localization to plasma membrane GO:1903076 9.43 INS PIK3R1
11 negative regulation of blood vessel diameter GO:0097756 9.37 CRP INS
12 regulation of insulin secretion GO:0050796 9.33 ABCC8 GCG KCNJ11
13 adaptive thermogenesis GO:1990845 9.32 UCP1 UCP2
14 diet induced thermogenesis GO:0002024 9.26 ADRB2 UCP1
15 mitochondrial transmembrane transport GO:1990542 8.96 UCP1 UCP2
16 response to cold GO:0009409 8.8 ADRB2 UCP1 UCP2

Molecular functions related to Acute Insulin Response according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor binding GO:0005158 9.32 INS PIK3R1
2 inward rectifier potassium channel activity GO:0005242 9.26 KCNJ11 KCNJ5
3 insulin-like growth factor receptor binding GO:0005159 9.16 INS PIK3R1
4 ATP-activated inward rectifier potassium channel activity GO:0015272 8.65 KCNJ11
5 oxidative phosphorylation uncoupler activity GO:0017077 8.62 UCP1 UCP2

Sources for Acute Insulin Response

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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