MCID: ACT071
MIFTS: 60

Acute Kidney Failure

Categories: Blood diseases, Bone diseases, Genetic diseases, Nephrological diseases

Aliases & Classifications for Acute Kidney Failure

MalaCards integrated aliases for Acute Kidney Failure:

Name: Acute Kidney Failure 12 15 37
Acute Renal Failure 74 32
Pre-Renal Acute Kidney Injury 71
Kidney Failure, Acute 71
Renal Failure Acute 54
Acute Kidney Injury 43

Classifications:



External Ids:

Disease Ontology 12 DOID:3021
MeSH 43 D058186
UMLS 71 C0022660 C3854173

Summaries for Acute Kidney Failure

MalaCards based summary : Acute Kidney Failure, also known as acute renal failure, is related to kidney cortex necrosis and end stage renal disease. An important gene associated with Acute Kidney Failure is MGAT3-AS1 (MGAT3 Antisense RNA 1), and among its related pathways/superpathways is Uricosurics Pathway, Pharmacodynamics. The drugs Metformin and Pirfenidone have been mentioned in the context of this disorder. Affiliated tissues include Bone and Adipose, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 74 Acute kidney injury (AKI), previously called acute renal failure (ARF), is an abrupt loss of kidney... more...

Related Diseases for Acute Kidney Failure

Diseases in the Kidney Disease family:

Acute Kidney Failure Renal Infectious Disease
Chronic Kidney Disease Ren-Related Kidney Disease

Diseases related to Acute Kidney Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1334)
# Related Disease Score Top Affiliating Genes
1 kidney cortex necrosis 33.2 SLC22A12 ADAMTS13
2 end stage renal disease 32.7 REN CST3 CFH ALB
3 hemolytic-uremic syndrome 32.6 HP CFH ADAMTS13
4 hemolytic uremic syndrome, atypical 1 32.2 HP CFH ADAMTS13
5 hepatorenal syndrome 31.8 REN NPPA LCN2 IL18 HAVCR1 GPT
6 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 31.5 PIK3C2A MB CPT2
7 acute kidney tubular necrosis 31.4 REN PIK3C2A NPPA MB LCN2 IL18
8 acute pyelonephritis 31.3 LCN2 GPT ALB
9 hypokalemia 31.3 REN PIK3C2A ALB
10 neuroleptic malignant syndrome 31.2 PIK3C2A MB GPT
11 acute liver failure 31.2 HGF GPT ALB
12 thrombotic thrombocytopenic purpura 31.2 HP CFH ADAMTS13
13 cardiac tamponade 31.1 REN PIK3C2A ALB
14 nephrolithiasis 31.0 SLC22A12 LCN2 B2M ALB
15 glomerulonephritis 31.0 LCN2 CFH B2M ALB
16 peripheral artery disease 31.0 IL18 HGF CST3
17 hypothyroidism 30.9 REN PIK3C2A GPT CST3 ALB
18 al amyloidosis 30.9 B2M ADAMTS13
19 urinary tract obstruction 30.9 REN LCN2 HAVCR1 EGF CST3 B2M
20 cystitis 30.9 IL18 EGF CST3
21 leptospirosis 30.9 PIK3C2A LCN2 IL18
22 cardiac arrest 30.9 REN PIK3C2A LCN2 GPT ALB
23 pulmonary embolism 30.8 NPPA MB ALB
24 dysentery 30.8 HP GPT ALB
25 hypoaldosteronism 30.8 REN NPPA
26 fanconi syndrome 30.8 SLC22A6 SLC22A12 B2M ALB
27 dengue hemorrhagic fever 30.8 IL18 GPT ALB
28 visceral leishmaniasis 30.8 IL18 CST3 ALB
29 renal tuberculosis 30.8 REN B2M
30 pericardial effusion 30.8 REN PIK3C2A NPPA GPT ALB
31 blackwater fever 30.8 MB HP
32 pyelonephritis 30.8 LCN2 GPT ALB
33 pulmonary edema 30.7 REN PIK3C2A NPPA HP
34 hepatic encephalopathy 30.7 IL18 GPT ALB
35 interstitial nephritis 30.7 REN HAVCR1 B2M ALB
36 renovascular hypertension 30.7 REN NPPA LCN2
37 cholecystitis 30.7 HP GPT EGF ALB
38 uremia 30.7 REN B2M ALB
39 pseudohyperkalemia, familial, 2, due to red cell leak 30.7 REN PIK3C2A MB
40 vascular disease 30.7 REN IL18 HP CST3 ALB
41 disseminated intravascular coagulation 30.7 PIK3C2A MB GPT ADAMTS13
42 acute cystitis 30.6 REN LCN2 IL18 GPT CST3 ALB
43 chronic pyelonephritis 30.6 REN B2M ALB
44 biliary atresia 30.6 HGF GPT ALB
45 alcoholic liver cirrhosis 30.6 HGF GPT ALB
46 arteriosclerosis 30.5 IL18 HGF GPT CST3
47 exanthem 30.5 PIK3C2A GPT ALB
48 bronchopneumonia 30.5 HP GPT ALB
49 virus associated hemophagocytic syndrome 30.5 PIK3C2A MB
50 liver cirrhosis 30.5 REN NPPA HP HGF GPT ALB

Comorbidity relations with Acute Kidney Failure via Phenotypic Disease Network (PDN): (show top 50) (show all 96)


Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Cystitis Acute Myocardial Infarction
Acute Pancreatitis Acute Proliferative Glomerulonephritis
Acute Vascular Insufficiency of Intestine Alcoholic Liver Cirrhosis
Alzheimer Disease Aortic Aneurysm
Aortic Valve Disease 1 Bacteremia 2
Benign Renovascular Hypertension Bladder Cancer
Bladder Neck Obstruction Bleeding Disorder, Platelet-Type, 11
Bronchitis Bronchopneumonia
Candidiasis Cardiac Arrest
Cardiogenic Shock Chronic Intestinal Vascular Insufficiency
Chronic Rapidly Progressive Glomerulonephritis Colorectal Cancer
Cystitis Decubitus Ulcer
Deficiency Anemia Dermatomycosis
Diabetic Polyneuropathy Disseminated Intravascular Coagulation
Encephalopathy Esophageal Candidiasis
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Generalized Atherosclerosis Goodpasture Syndrome
Gout Heart Disease
Hemolytic-Uremic Syndrome Hepatic Encephalopathy
Hepatitis Hepatorenal Syndrome
Hydronephrosis Hypertension, Essential
Hypertensive Encephalopathy Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome
Hypoglycemia Hypoglycemic Coma
Hypothyroidism Intermediate Coronary Syndrome

Graphical network of the top 20 diseases related to Acute Kidney Failure:



Diseases related to Acute Kidney Failure

Symptoms & Phenotypes for Acute Kidney Failure

MGI Mouse Phenotypes related to Acute Kidney Failure:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.21 ALB B2M CFH CPT2 CST3 HGF
2 hematopoietic system MP:0005397 10.13 ADAMTS13 B2M CFH HGF HP IL18
3 homeostasis/metabolism MP:0005376 10.13 ADAMTS13 ALB B2M CFH CPT2 CST3
4 immune system MP:0005387 9.93 ADAMTS13 ALB B2M CFH CPT2 EGF
5 mortality/aging MP:0010768 9.8 ADAMTS13 ALB B2M CFH CPT2 CST3
6 renal/urinary system MP:0005367 9.28 ALB CFH HP LCN2 NPPA PIK3C2A

Drugs & Therapeutics for Acute Kidney Failure

Drugs for Acute Kidney Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 570)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4 657-24-9 14219 4091
2
Pirfenidone Approved, Investigational Phase 4 53179-13-8 40632
3
Lithium carbonate Approved Phase 4 554-13-2
4
Insulin lispro Approved Phase 4 133107-64-9
5
Insulin glargine Approved Phase 4 160337-95-1
6
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
7
Epoprostenol Approved Phase 4 35121-78-9, 61849-14-7 5282411 5280427
8
Nadroparin Approved, Investigational Phase 4
9
Ibuprofen Approved Phase 4 15687-27-1 3672
10
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
11
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
12
Desflurane Approved Phase 4 57041-67-5 42113
13
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
14
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
15
Simvastatin Approved Phase 4 79902-63-9 54454
16
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492 6473866
17
Mycophenolic acid Approved Phase 4 24280-93-1 446541
18
Sirolimus Approved, Investigational Phase 4 53123-88-9 5284616 6436030 46835353
19
Morphine Approved, Investigational Phase 4 57-27-2 5288826
20
Cidofovir Approved Phase 4 113852-37-2 60613
21
Theophylline Approved Phase 4 58-55-9 2153
22
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
23
Everolimus Approved Phase 4 159351-69-6 70789204 6442177
24
Micafungin Approved, Investigational Phase 4 235114-32-6 477468 3081921
25
Perindopril Approved Phase 4 107133-36-8, 82834-16-0 107807
26
Moexipril Approved Phase 4 103775-10-6 91270
27
Enalapril Approved, Vet_approved Phase 4 75847-73-3 40466924 5362032
28
Trandolapril Approved Phase 4 87679-37-6 5484727
29
Fosinopril Approved Phase 4 98048-97-6 55891
30
Enalaprilat Approved Phase 4 76420-72-9 6917719
31
Ramipril Approved Phase 4 87333-19-5 5362129
32
Benazepril Approved, Investigational Phase 4 86541-75-5 5362124
33
Quinapril Approved, Investigational Phase 4 85441-61-8 54892
34
Captopril Approved Phase 4 62571-86-2 44093
35
Liraglutide Approved Phase 4 204656-20-2 44147092
36
Glucagon Approved Phase 4 16941-32-5
37
Vancomycin Approved Phase 4 1404-90-6 14969 441141
38
Terlipressin Approved, Investigational Phase 4 14636-12-5 72081
39
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
40
Mannitol Approved, Investigational Phase 4 69-65-8 6251 453
41
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
42
Tinzaparin Approved Phase 4 9041-08-1, 9005-49-6 25244225
43
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
44
Digoxin Approved Phase 4 20830-75-5 30322 2724385
45
Phenobarbital Approved, Investigational Phase 4 50-06-6 4763
46
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
47
Levetiracetam Approved Phase 4 102767-28-2 441341
48
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
49
Lacosamide Approved Phase 4 175481-36-4, 860352-01-8 219078
50
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345

Interventional clinical trials:

(show top 50) (show all 1475)
# Name Status NCT ID Phase Drugs
1 A Randomized Controlled Multi-Center Trial of the Early Application of CRRT in Patients With Severe Sepsis or Septic Shock Unknown status NCT00837057 Phase 4
2 Minimizing Contrast Utilization With IVUS Guidance in Coronary Angioplasty to Avoid Acute Nephropathy: The MOZART-II Study Unknown status NCT02743156 Phase 4
3 The Effects of Dexmedetomidine on Postoperative Renal Function in Valvular Heart Surgery Unknown status NCT01886079 Phase 4 dexmedetomidine;Saline
4 Fenoldopam for Prevention of Acute kidNey Injury in Patients With aCute coronarY Syndrome Undergoing Coronary Angiography and/or Percutaneous Coronary Intervention - The FANCY Trial Unknown status NCT01690832 Phase 4 standard saline infusion;fenoldopam infusion
5 Short-Term Alpha Lipoic Acid Therapy for Prevention of Contrast-induced Acute Kidney Injury and Endothelial Dysfunction in Type 2 Diabetes Unknown status NCT01978405 Phase 4 Alpha lipoic acid
6 Pirfenidone Effect on the Recovery of Renal Function in Patients With Septic Acute Kidney Injury Unknown status NCT02530359 Phase 4 Pirfenidone extended release;Placebo equivalent
7 Preventing Contrast Induced Nephropathy After Transcatheter Aortic Valve Replacement Unknown status NCT03121053 Phase 4 sodium bicarbonate;hypotone saline
8 Comparison of Slow Efficiency Daily Dialysis (SLEDD) With Unfractionated Heparin Versus Citrasate in Critically Ill Patients. Unknown status NCT01228292 Phase 4 Unfractionated heparin;Citrasate
9 Effects of Different Inhalational Anesthetic Agents on the Incidence of Clinical and Subclinical Acute Kidney Injury After Liver Resection Surgery: a Pilot Study Unknown status NCT02174575 Phase 4 Sevoflurane;Desflurane
10 Efficacy and Safety of Heparin-coated Surface-treated Polyacrylonitrile Membrane Hemofilter in Critical Ill CRRT Patients Continuous Renal Replacement Therapy Patients Unknown status NCT02355873 Phase 4
11 Lithium in Cardiac Surgery Related Acute Kidney Injury: A Pilot Study Unknown status NCT03056248 Phase 4 Placebo oral capsule;Lithium Carbonate
12 Nutritional Therapy to Prevent Progression of Acute Kidney Injury to Chronic Kidney Disease Unknown status NCT02831062 Phase 4
13 Effects of Dexmedetomidine and Dopamine on Renal Function After Selective Major Surgery in Adult Patients Unknown status NCT03170739 Phase 4 Dexmedetomidine;Dopamine
14 Prevention of Acute Kidney Injury by N-Acetylcystein in Patients Undergone Cardiac Valve Replacement Unknown status NCT03440268 Phase 4 N Acetyl Cysteine;Placebos
15 Influence of Albumin on the Development of Acute Renal Dysfunction Associated With Cardiac Surgery Under Extracorporeal Circulation Unknown status NCT03373318 Phase 4 Human albumin;Plasmalyte
16 Protective Effects of Oral L-Arginine Supplement in Patients With CKD After Intravenous Contrast Media Injection Unknown status NCT02455960 Phase 4
17 Phase 4 Study of Alprostadil Prevent Contrast Induced Nephropathy in Patients Receiving a Cardiac Catheterization Unknown status NCT01722513 Phase 4 Alprostadil ﹠control
18 Neutrophil gElatinase-associated Lipocalin alloWs Intensive treatMent Of cOntrast Induced Nephropathy in Patients With Urgent/Emergency Percutaneous Coronary Intervention Unknown status NCT01491243 Phase 4 Intensive treatment with sodium bicarbonate;Standard treatment with saline infusion
19 Metformin and Sitagliptin Therapy for Adult Patients With Type 2 Diabetes Admitted to the General Medical Unit Unknown status NCT02250794 Phase 4 metformin and sitagliptin;insulin glargine and insulin lispro;metformin and sitagliptin;insulin glargine and insulin lispro
20 Phase IV Study of Perioperative Steroid's Effects on Death or MI in High-Risk Patients Undergoing Cardiac Surgery Requiring Cardiopulmonary Bypass Unknown status NCT00427388 Phase 4 Methylprednisolone
21 The Therapy of Tacrolimus Combined With Entecavir on HBV Associated Glomerulonephritis : A Multicenter, Prospective, Randomized, Controlled, Single-blind Trial. Unknown status NCT03062813 Phase 4 Tacrolimus &entecavir;placebo & entecavir
22 Living With Statins - The Impact of Cholesterol Lowering Drugs on Health, Lifestyle and Well-being Unknown status NCT02796378 Phase 4 Training+Simvastatin+Q10-placebo;Training+Simvastatin-placebo+Q10-placebo;Training+Simvastatin+Q10
23 Heparin Versus Prostacyclin in Continuous Hemodiafiltration for Acute Renal Failure: Effects on Platelet Responsiveness in the Systemic Circulation and Across the Filter. Completed NCT00890214 Phase 4 prostacyclin;heparin
24 The Hannover-Dialysis-Outcome (HAN-D-OUT)-Study: Comparison of Standard Versus Intensified Extended Dialysis in Treatment of Patients With Acute Kidney Injury in the Intensive-Care Unit Completed NCT00529139 Phase 4
25 Metabolic Pattern of Cyclosporine A - Association of Secondary- and Cyclic Metabolites With Acute Renal Failure in Heart Transplant Recipients Completed NCT00264355 Phase 4 cyclosporine A
26 Sup-Icu RENal (SIREN) - a Sub-analysis of the Prospective SUP (Stress Ulcer Prophylaxis)-ICU Trial on the Risk of GI- Bleeding in ICU Patients Receiving Renal Replacement Therapy Completed NCT02718261 Phase 4 Pantoprazole;Saline 0.9% (matching placebo)
27 Minimizing cOntrast utiliZAtion With IVUS Guidance in coRonary angioplasTy: The MOZART Study Completed NCT01947335 Phase 4
28 Nadroparin Anticoagulation for Continuous Venovenous Hemofiltration (CVVH), a Randomized Cross-over Trial Comparing Hemostasis Between Two Hemofiltration Rates Completed NCT00965328 Phase 4
29 Citrate-based Regional Anticoagulation Versus Heparin for Continuous Renal Replacement Therapy in Critically Ill Patients With Acute Renal Failure: a Randomized Controlled Trial Completed NCT01269112 Phase 4
30 Use of Fondaparinux in Critically Ill Patients With Renal Failure Completed NCT01467583 Phase 4 Fondaparinux
31 Multicentre, Unblinded, Open Label, Randomised, Controlled Trial to Assess the Effect of Augmented Vs. Normal Continuous Renal Replacement Therapy (CRRT) on 90-Day All-Cause Mortality of Intensive Care Unit Patients With Severe Acute Renal Failure (ARF). Completed NCT00221013 Phase 4
32 Pharmacokinetics of Invanz® (Ertapenem) in Critically Ill Patients Receiving Continuous Venovenous Hemodialysis Completed NCT00877370 Phase 4 ertapenem
33 Effect of N-acetylcysteine on Prevention of Acute Kidney Injury in High Risk Patients Undergoing Off-pump Coronary Artery Bypass Graft Completed NCT01394419 Phase 4 N-acetylcysteine;Saline
34 Safety and Efficacy of the Use of Regional Anticoagulation With Citrate in Continuous Venovenous Hemofiltration, a Randomized Controlled Trial Comparing Anticoagulation With Citrate to the Low Molecular Weight Heparin Nadroparin Completed NCT00286273 Phase 4 trisodium citrate;nadroparin
35 Effect of the Intensity of Continuous Renal Replacement Therapy in Patients With Cardiac Surgery Associated Acute Kidney Injury (CRITERIA STUDY) Completed NCT01560650 Phase 4
36 The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery Completed NCT01920126 Phase 4 sodium bicarbonate;Saline
37 Early Hydration in Acute Myocardial Infarction: Sodium Bicarbonate Versus Saline for the Prevention on Contrast-induced Acute Kidney Injury Completed NCT01742130 Phase 4 sodium bicarbonate solution;Isotonic saline
38 Preloading Magnesium Attenuate Cisplatin-induced Nephrotoxicity Completed NCT02481518 Phase 4 Magnesium
39 The Protection of Telipression on Developing of Acute Kidney Injury in Cirrhotic Patients With Upper-gastroentestinal Bleeding Completed NCT04358016 Phase 4 Terlipressin;Somatostatin
40 The EUROpean and Asian Cardiac and Renal Remote Ischemic Pre-conditioning Study : A Prospective, Randomized Control Trial Completed NCT02195726 Phase 4
41 Regional Citrate Versus Systemic Heparin Anticoagulation for Continuous Renal Replacement Therapy in Critically Ill Patients With Acute Kidney Injury Completed NCT02669589 Phase 4 Heparin;Citrate
42 Outcomes of the Use of Sodium Bicarbonate (8.4%) Solution as a Catheter Lock Solution as a Catheter Lock Solution to Prevent Hemodialysis Catheter Loss Due to Lumen Clot Formation Completed NCT03627884 Phase 4 Sodium Bicarbonate Catheter Lock Solution;Normal Saline Catheter Lock Solution
43 The Effect of Atorvastatin on Prevention of Postoperative Acute Kidney Injury in Patients Undergoing Aortic Surgery Completed NCT02157337 Phase 4 Atorvastatin;placebo
44 Trial to Assess the Efficacy and Safety of Nafamostat Mesilate During Continuous Renal Replacement Therapy Completed NCT02478242 Phase 4 Nafamostat mesilate;Normal saline
45 Effect of Aminophylline on Contrast Induced Acute Kidney Injury in Patients With Acute Myocardial Infarction Treated With Primary Angioplasty Completed NCT01594489 Phase 4 Aminophylline;Hydration plus N-acetylcisteine
46 Personalized Versus Standard Hydration for Prevention of Contrast Induced Acute Kidney Injury. A Randomized Trial With Bioimpedance Analysis. Completed NCT02225431 Phase 4 sodium chloride infusion
47 A Comparison of Propofol Based Total Intravenous Anesthesia and Sevoflurane Based Balanced Anesthesia on Renal Protection During Lung Transplantation Under Extracorporeal Membrane Oxygenation - A Prospective, Randomized Trial Completed NCT02009280 Phase 4 Administration of anesthesia: Propofol;Administration of anesthesia: Sevoflurane
48 Multicenter Randomized Controlled Study of Rosuvastatin for Prevention of Contrast Induced Acute Kidney Injury in Patients With Diabetes and Slight to Moderate Renal Insufficient Completed NCT00786136 Phase 4 rosuvastatin
49 The Effect of Prophylactic Dexmedetomidine Administration on the Outcome in Patients Undergoing Surgery With Cardiopulmonary Bypass Completed NCT03091166 Phase 4 Dexmedetomidine
50 Impact of Early High-dose Atorvastatin Versus Rosuvastatin on Contrast Induced Acute Kidney Injury in Unselected Patients With Non- ST Elevation Acute Coronary Syndromes Scheduled for Early Invasive Strategy. Completed NCT01870804 Phase 4 Rosuvastatin;Atorvastatin

Search NIH Clinical Center for Acute Kidney Failure

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Bumetanide
Ethacrynate Sodium
Ethacrynic Acid
Furosemide
Mannitol hexanitrate
torsemide

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Acute Kidney Failure cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: acute kidney injury

Genetic Tests for Acute Kidney Failure

Anatomical Context for Acute Kidney Failure

MalaCards organs/tissues related to Acute Kidney Failure:

40
Kidney, Liver, Heart, Neutrophil, Lung, Bone, Testes
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Acute Kidney Failure:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
2 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
3 Kidney Proximal Tubule Proximal Tubule Cells Affected by disease, potential therapeutic candidate

Publications for Acute Kidney Failure

Articles related to Acute Kidney Failure:

(show top 50) (show all 23303)
# Title Authors PMID Year
1
Community acquired methicillin-resistant Staphylococcus aureus pneumonia leading to rhabdomyolysis: a case report. 61 54
20205915 2010
2
Tetanus as a cause of rhabdomyolysis and acute renal failure. 61 54
20040354 2010
3
Utility of urine myoglobin for the prediction of acute renal failure in patients with suspected rhabdomyolysis: a systematic review. 61 54
19797717 2009
4
Chickenpox: presentation and complications in adults. 54 61
20201174 2009
5
Serum neutrophil gelatinase-associated lipocalin correlates with kidney function in renal allograft recipients. 54 61
19708926 2009
6
Rhabdomyolysis and acute renal failure associated with the co-administration of daptomycin and an HMG-CoA reductase inhibitor. 61 54
19346518 2009
7
Aliskiren-associated acute renal failure with hyperkalemia. 61 54
19281746 2009
8
Tramadol overdose induced seizure, dramatic rise of CPK and acute renal failure. 54 61
19288949 2009
9
NGAL (neutrophil gelatinase-associated lipocalin) and L-FABP after percutaneous coronary interventions due to unstable angina in patients with normal serum creatinine. 61 54
19875355 2009
10
Neutrophil gelatinase-associated lipocalin and cystatin C could predict renal outcome in patients undergoing kidney allograft transplantation: a prospective study. 54 61
19249501 2009
11
The role of stress-activated protein kinase signaling in renal pathophysiology. 54 61
18982195 2009
12
[Rhabdomyolysis due to muscle enzyme deficiencies]. 61 54
19240776 2009
13
Early recognition of renal toxicity of high-dose methotrexate therapy: a case report. 54 61
19131789 2008
14
The syndrome of rhabdomyolysis: complications and treatment. 54 61
19046720 2008
15
[Rhabdomyolysis after laparoscopic nephrectomy: case report]. 54 61
18972919 2008
16
Acute renal failure due to rhabdomyolysis in a child with McArdle disease. 54 61
17899190 2008
17
Prognostic values of serum cystatin C and beta2 microglobulin, urinary beta2 microglobulin and N-acetyl-beta-D-glucosaminidase in early acute renal failure after liver transplantation. 54 61
18713542 2008
18
[Acute rhabdomyolysis: a case report and literature review]. 54 61
18843854 2008
19
Severe rhabdomyolysis with hypoglycemia in an adult patient with carnitine palmitoyltransferase II deficiency. 54 61
18471680 2008
20
Daptomycin-induced acute renal and hepatic toxicity without rhabdomyolysis. 61 54
18381844 2008
21
Novel HGPRT 293 A>G point mutation presenting as neonatal acute renal failure. 54 61
17934765 2008
22
Lesch-Nyhan syndrome presenting with acute renal failure in a 3-day-old newborn. 61 54
17701224 2008
23
Relationship of serum cystatin C with C-reactive protein and apolipoprotein A1 in patients on hemodialysis. 54 61
18704820 2008
24
Rifaximin does not induce toxin production or phage-mediated lysis of Shiga toxin-producing Escherichia coli. 54 61
17526759 2007
25
Acute respiratory failure in adult patients with dengue virus infection. 54 61
17620647 2007
26
Gabapentin-induced severe myopathy. 54 61
17565043 2007
27
Alteration in renal organic anion transporter 1 after ischemia/reperfusion in cadaveric renal allografts. 54 61
17312013 2007
28
HPRT deficiency in a two-month-old child presenting acute renal failure and gout with a new deletion of two bases in exon 3 of the HPRT gene. 54 61
17416296 2007
29
Genetic analysis of the complement factor H related 5 gene in haemolytic uraemic syndrome. 54 61
17000000 2007
30
[Case of fulminant type 1 diabetes mellitus complicated with acute renal failure treated with continuous hemodiafiltration]. 61 54
17315734 2007
31
Could neutrophil-gelatinase-associated lipocalin and cystatin C predict the development of contrast-induced nephropathy after percutaneous coronary interventions in patients with stable angina and normal serum creatinine values? 54 61
17901710 2007
32
Interleukin-18 and the pathogenesis of inflammatory diseases. 54 61
17336692 2007
33
Clopidogrel-precipitated rhabdomyolysis in a stable heart transplant patient. 54 61
17200431 2007
34
Exertional rhabdomyolysis and acute renal failure in marathon runners. 61 54
17465608 2007
35
Prevention and treatment of infections in patients with cirrhosis. 61 54
17223498 2007
36
Continuous low-dose human atrial natriuretic peptide promotes diuresis in oliguric patients after living donor liver transplantation. 61 54
17175340 2006
37
Access to the kidney transplant wait list. 54 61
16952294 2006
38
An adolescent girl with Meyer-Betz syndrome. 54 61
16328090 2006
39
A double-blinded, randomized, placebo-controlled trial of infliximab in subjects with active pulmonary sarcoidosis. 61 54
18038919 2006
40
Analysis of morbidity in liver transplant recipients following human albumin supplementation: a retrospective pilot study. 61 54
17007153 2006
41
Safety of paracentesis in inpatients. 54 61
16995339 2006
42
Rhabdomyolysis and acute renal failure associated with influenza virus type B infection. 54 61
16909056 2006
43
[Hepatocyte growth factor and kidney]. 54 61
17063438 2006
44
Novel compound heterozygote mutations (H234Q/R1206X) of the ADAMTS13 gene in an adult patient with Upshaw-Schulman syndrome showing predominant episodes of repeated acute renal failure. 54 61
16449289 2006
45
Molecular, biochemical, and genetic characterization of a female patient with Lesch-Nyhan disease. 61 54
16343967 2006
46
Which of the cardiac natriuretic peptides is most effective for the treatment of congestive heart failure, renal failure and cancer? 61 54
16487258 2006
47
Neutrophil-gelatinase-associated lipocalin and renal function after percutaneous coronary interventions. 54 61
16772710 2006
48
Severe secondary deficiency of von Willebrand factor-cleaving protease (ADAMTS13) in patients with sepsis-induced disseminated intravascular coagulation: its correlation with development of renal failure. 54 61
16189276 2006
49
Hemolytic uremic syndrome-associated Shiga toxins promote endothelial-cell secretion and impair ADAMTS13 cleavage of unusually large von Willebrand factor multimers. 54 61
16131569 2005
50
Partial hypoxanthine-guanine phosphoribosyltransferase deficiency presenting as acute renal failure. 61 54
16240158 2005

Variations for Acute Kidney Failure

Expression for Acute Kidney Failure

Search GEO for disease gene expression data for Acute Kidney Failure.

Pathways for Acute Kidney Failure

Pathways related to Acute Kidney Failure according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.7 SLC22A6 SLC22A12

GO Terms for Acute Kidney Failure

Cellular components related to Acute Kidney Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.93 REN NPPA LCN2 IL18 HP HGF
2 extracellular exosome GO:0070062 9.73 SLC22A6 SLC22A12 PIK3C2A MB LCN2 HP
3 endoplasmic reticulum lumen GO:0005788 9.71 CST3 B2M ALB ADAMTS13
4 platelet alpha granule lumen GO:0031093 9.54 HGF EGF ALB
5 specific granule lumen GO:0035580 9.5 LCN2 HP B2M
6 extracellular space GO:0005615 9.44 REN NPPA LCN2 IL18 HP HGF
7 tertiary granule lumen GO:1904724 9.43 HP CST3 B2M

Biological processes related to Acute Kidney Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cold-induced thermogenesis GO:0120162 9.33 LCN2 IL18 CPT2
2 cellular protein metabolic process GO:0044267 9.26 NPPA CST3 B2M ALB
3 response to drug GO:0042493 9.02 SLC22A12 REN LCN2 CST3 B2M

Molecular functions related to Acute Kidney Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.5 SLC22A6 LCN2 HGF CST3 CFH B2M
2 enterobactin binding GO:1903981 8.62 LCN2 ALB

Sources for Acute Kidney Failure

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17 EFO
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