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MCID: ACT071
MIFTS: 60

Acute Kidney Failure

Categories: Blood diseases, Bone diseases, Genetic diseases, Nephrological diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Acute Kidney Failure

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MalaCards integrated aliases for Acute Kidney Failure:

Name: Acute Kidney Failure 12 15 37
Acute Renal Failure 74 6 32
Pre-Renal Acute Kidney Injury 71
Kidney Failure, Acute 71
Renal Failure Acute 54
Acute Kidney Injury 44

Classifications:

MalaCards categories:
Global: Genetic diseases
Anatomical: Nephrological diseases Bone diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:3021
MeSH 44 D058186
UMLS 71 C0022660 C3854173
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Summaries for Acute Kidney Failure

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MalaCards based summary : Acute Kidney Failure, also known as acute renal failure, is related to kidney cortex necrosis and hemolytic-uremic syndrome. An important gene associated with Acute Kidney Failure is MGAT3-AS1 (MGAT3 Antisense RNA 1), and among its related pathways/superpathways is Uricosurics Pathway, Pharmacodynamics. The drugs Pirfenidone and Lithium carbonate have been mentioned in the context of this disorder. Affiliated tissues include Bone and Adipose, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 74 Acute kidney injury (AKI), previously called acute renal failure (ARF), is an abrupt loss of kidney... more...

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Related Diseases for Acute Kidney Failure

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Diseases in the Kidney Disease family:

Acute Kidney Failure Renal Infectious Disease
Chronic Kidney Disease Ren-Related Kidney Disease

Diseases related to Acute Kidney Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1370)
# Related Disease Score Top Affiliating Genes
1 kidney cortex necrosis 32.4 SLC22A12 ADAMTS13
2 hemolytic-uremic syndrome 31.9 HP CFH ADAMTS13
3 hemolytic uremic syndrome, atypical 1 31.8 HP CFH ALB ADAMTS13
4 end stage renal disease 31.5 REN HAVCR1 CST3 CFH B2M ALB
5 hepatorenal syndrome 31.5 REN NPPA LCN2 IL18 GPT CST3
6 acute pyelonephritis 31.3 LCN2 GPT ALB
7 thrombotic thrombocytopenic purpura 31.2 HP CFH ADAMTS13
8 neuroleptic malignant syndrome 31.2 PIK3C2A MB GPT
9 urinary tract obstruction 31.2 REN LCN2 HAVCR1 EGF B2M ALB
10 acute liver failure 31.2 HGF GPT ALB
11 cardiac tamponade 31.1 REN PIK3C2A ALB
12 hypothyroidism 31.0 REN PIK3C2A GPT CST3 ALB
13 glomerulonephritis 31.0 LCN2 CFH B2M ALB
14 aortic aneurysm, familial abdominal, 1 31.0 REN LCN2 CST3 ALB
15 pre-eclampsia 31.0 REN NPPA IL18 CST3 ALB
16 interstitial nephritis 31.0 REN B2M ALB
17 acute poststreptococcal glomerulonephritis 30.9 NPPA CFH ALB
18 hepatic coma 30.8 GPT ALB
19 cystitis 30.8 IL18 EGF CST3
20 leptospirosis 30.8 PIK3C2A LCN2 IL18
21 dysentery 30.8 HP GPT ALB
22 fanconi syndrome 30.8 SLC22A6 SLC22A12 B2M ALB
23 pericardial effusion 30.8 REN PIK3C2A NPPA GPT ALB
24 blackwater fever 30.8 MB HP
25 pneumonia 30.8 PIK3C2A MB IL18 GPT ALB
26 disease by infectious agent 30.8 IL18 HP GPT ALB
27 uremia 30.8 REN B2M ALB
28 thrombocytopenia 30.8 PIK3C2A IL18 HP GPT CFH ALB
29 acute kidney tubular necrosis 30.8 REN PIK3C2A NPPA MB LCN2 IL18
30 patent ductus arteriosus 1 30.8 REN LCN2 ALB
31 proteinuria, chronic benign 30.8 REN B2M ALB
32 cholecystitis 30.8 HP GPT EGF ALB
33 hepatic encephalopathy 30.8 IL18 GPT ALB
34 pulmonary edema 30.8 REN PIK3C2A NPPA HP
35 hypoaldosteronism 30.7 REN NPPA
36 pyelonephritis 30.7 LCN2 GPT ALB
37 renal tuberculosis 30.7 REN B2M
38 renovascular hypertension 30.7 REN NPPA LCN2
39 disseminated intravascular coagulation 30.7 PIK3C2A MB GPT ADAMTS13
40 pseudohyperkalemia, familial, 2, due to red cell leak 30.6 REN PIK3C2A MB
41 vascular disease 30.6 REN IL18 HP CST3 ALB
42 cardiac arrest 30.6 REN PIK3C2A LCN2 GPT ALB
43 acute myocardial infarction 30.6 PIK3C2A NPPA MB CST3 ADAMTS13
44 arteriosclerosis 30.6 IL18 HGF GPT CST3
45 biliary atresia 30.6 HGF GPT ALB
46 alcoholic liver cirrhosis 30.6 HGF GPT ALB
47 chronic pyelonephritis 30.5 REN B2M ALB
48 obstructive nephropathy 30.5 REN LCN2 HGF HAVCR1 EGF ALB
49 thrombotic microangiopathy 30.5 HP ADAMTS13
50 peritonitis 30.5 IL18 B2M ALB

Comorbidity relations with Acute Kidney Failure via Phenotypic Disease Network (PDN): (show top 50) (show all 96)


Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Cystitis Acute Myocardial Infarction
Acute Pancreatitis Acute Proliferative Glomerulonephritis
Acute Vascular Insufficiency of Intestine Alcoholic Liver Cirrhosis
Alzheimer Disease Aortic Aneurysm
Aortic Valve Disease 1 Bacteremia 2
Benign Renovascular Hypertension Bladder Cancer
Bladder Neck Obstruction Bleeding Disorder, Platelet-Type, 11
Bronchitis Bronchopneumonia
Candidiasis Cardiac Arrest
Cardiogenic Shock Chronic Intestinal Vascular Insufficiency
Chronic Rapidly Progressive Glomerulonephritis Colorectal Cancer
Cystitis Decubitus Ulcer
Deficiency Anemia Dermatomycosis
Diabetic Polyneuropathy Disseminated Intravascular Coagulation
Encephalopathy Esophageal Candidiasis
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Generalized Atherosclerosis Goodpasture Syndrome
Gout Heart Disease
Hemolytic-Uremic Syndrome Hepatic Encephalopathy
Hepatitis Hepatorenal Syndrome
Hydronephrosis Hypertension, Essential
Hypertensive Encephalopathy Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome
Hypoglycemia Hypoglycemic Coma
Hypothyroidism Intermediate Coronary Syndrome

Graphical network of the top 20 diseases related to Acute Kidney Failure:



Diseases related to Acute Kidney Failure
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Symptoms & Phenotypes for Acute Kidney Failure

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MGI Mouse Phenotypes related to Acute Kidney Failure:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.21 ALB B2M CFH CPT2 CST3 HGF
2 hematopoietic system MP:0005397 10.13 ADAMTS13 B2M CFH HGF HP IL18
3 homeostasis/metabolism MP:0005376 10.13 ADAMTS13 ALB B2M CFH CPT2 CST3
4 immune system MP:0005387 9.93 ADAMTS13 ALB B2M CFH CPT2 EGF
5 mortality/aging MP:0010768 9.8 ADAMTS13 ALB B2M CFH CPT2 CST3
6 renal/urinary system MP:0005367 9.28 ALB CFH HP LCN2 NPPA PIK3C2A
Sources

Drugs & Therapeutics for Acute Kidney Failure

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Drugs for Acute Kidney Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 382)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pirfenidone Approved, Investigational Phase 4 53179-13-8 40632
2
Lithium carbonate Approved Phase 4 554-13-2
3
Nadroparin Approved, Investigational Phase 4
4
Somatostatin Approved, Investigational Phase 4 51110-01-1, 38916-34-6 53481605
5
Thrombin Approved, Investigational Phase 4
6
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
7
Epoprostenol Approved Phase 4 61849-14-7, 35121-78-9 5280427 5282411
8
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
9
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
10
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
11
Atorvastatin Approved Phase 4 134523-00-5 60823
12
Aminophylline Approved Phase 4 317-34-0 9433
13
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
14
Phenobarbital Approved, Investigational Phase 4 50-06-6 4763
15
Lacosamide Approved Phase 4 860352-01-8, 175481-36-4 219078
16
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
17
Levetiracetam Approved Phase 4 102767-28-2 441341
18
Cidofovir Approved Phase 4 113852-37-2 60613
19
Pantoprazole Approved Phase 4 102625-70-7 4679
20
Dalteparin Approved Phase 4 9005-49-6
21
Tinzaparin Approved Phase 4 9041-08-1, 9005-49-6 25244225
22
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
23
Digoxin Approved Phase 4 20830-75-5 30322 2724385
24
Ephedrine Approved Phase 4 299-42-3 9294
25
Pseudoephedrine Approved Phase 4 90-82-4 7028
26
Propranolol Approved, Investigational Phase 4 525-66-6 4946
27
Sofosbuvir Approved Phase 4 1190307-88-0 45375808
28
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198
29
Norepinephrine Approved Phase 4 51-41-2 439260
30
Racepinephrine Approved Phase 4 329-65-7 838
31
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
32
Empagliflozin Approved Phase 4 864070-44-0
33
Alprostadil Approved, Investigational Phase 4 745-65-3 149351 5280723
34
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
35
Heparin Approved, Investigational Phase 4 9005-49-6 772 9812414
36
Ganciclovir Approved, Investigational Phase 4 82410-32-0 3454
37
carbamide peroxide Approved Phase 4 124-43-6
38
Cysteine Approved, Nutraceutical Phase 4 52-90-4 5862
39
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
40 Tezosentan Investigational Phase 4 180384-57-0
41
Nafamostat Investigational Phase 4 81525-10-2
42
Simendan Investigational Phase 4 131741-08-7
43
Ferulic acid Experimental Phase 4 1135-24-6, 537-98-4 445858
44 Antidepressive Agents Phase 4
45 Alpha-lipoic Acid Phase 4
46 Thioctic Acid Phase 4
47 Psychotropic Drugs Phase 4
48 Anticonvulsants Phase 4
49 Antifungal Agents Phase 4
50 Cyclosporins Phase 4

Interventional clinical trials:

(show top 50) (show all 968)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Heparin-coated Surface-treated Polyacrylonitrile Membrane Hemofilter in Critical Ill CRRT Patients Continuous Renal Replacement Therapy Patients Unknown status NCT02355873 Phase 4
2 A Randomized Controlled Multi-Center Trial of the Early Application of CRRT in Patients With Severe Sepsis or Septic Shock Unknown status NCT00837057 Phase 4
3 Short-Term Alpha Lipoic Acid Therapy for Prevention of Contrast-induced Acute Kidney Injury and Endothelial Dysfunction in Type 2 Diabetes Unknown status NCT01978405 Phase 4 Alpha lipoic acid
4 Pirfenidone Effect on the Recovery of Renal Function in Patients With Septic Acute Kidney Injury Unknown status NCT02530359 Phase 4 Pirfenidone extended release;Placebo equivalent
5 Comparison of Slow Efficiency Daily Dialysis (SLEDD) With Unfractionated Heparin Versus Citrasate in Critically Ill Patients. Unknown status NCT01228292 Phase 4 Unfractionated heparin;Citrasate
6 Minimizing Contrast Utilization With IVUS Guidance in Coronary Angioplasty to Avoid Acute Nephropathy: The MOZART-II Study Unknown status NCT02743156 Phase 4
7 The Effects of Dexmedetomidine on Postoperative Renal Function in Valvular Heart Surgery Unknown status NCT01886079 Phase 4 dexmedetomidine;Saline
8 Influence of Albumin on the Development of Acute Renal Dysfunction Associated With Cardiac Surgery Under Extracorporeal Circulation Unknown status NCT03373318 Phase 4 Human albumin;Plasmalyte
9 Lithium in Cardiac Surgery Related Acute Kidney Injury: A Pilot Study Unknown status NCT03056248 Phase 4 Placebo oral capsule;Lithium Carbonate
10 The Effect of Propofol and Sevoflurane Anesthesia on Renal Function in Patients Undergoing Back Surgery Unknown status NCT03336801 Phase 4 Propofol;Sevoflurane
11 Effects of Different Inhalational Anesthetic Agents on the Incidence of Clinical and Subclinical Acute Kidney Injury After Liver Resection Surgery: a Pilot Study Unknown status NCT02174575 Phase 4 Sevoflurane;Desflurane
12 Prevention of Acute Kidney Injury by N-Acetylcystein in Patients Undergone Cardiac Valve Replacement Unknown status NCT03440268 Phase 4 N Acetyl Cysteine;Placebos
13 Fenoldopam for Prevention of Acute kidNey Injury in Patients With aCute coronarY Syndrome Undergoing Coronary Angiography and/or Percutaneous Coronary Intervention - The FANCY Trial Unknown status NCT01690832 Phase 4 standard saline infusion;fenoldopam infusion
14 Phase 4 Study of Alprostadil Prevent Contrast Induced Nephropathy in Patients Receiving a Cardiac Catheterization Unknown status NCT01722513 Phase 4 Alprostadil ï¹ control
15 Preventing Contrast Induced Nephropathy After Transcatheter Aortic Valve Replacement Unknown status NCT03121053 Phase 4 sodium bicarbonate;hypotone saline
16 Safety and Efficacy of the Use of Regional Anticoagulation With Citrate in Continuous Venovenous Hemofiltration, a Randomized Controlled Trial Comparing Anticoagulation With Citrate to the Low Molecular Weight Heparin Nadroparin Completed NCT00286273 Phase 4 trisodium citrate;nadroparin
17 The Protection of Telipression on Developing of Acute Kidney Injury in Cirrhotic Patients With Upper-gastroentestinal Bleeding Completed NCT04358016 Phase 4 Terlipressin;Somatostatin
18 The Optimal Mode of Renal Replacement Therapy in Acute Kidney Injury (OMAKI) Study: A Pilot Randomized Controlled Trial of Convective Versus Diffusive Clearance Completed NCT00675818 Phase 4
19 Nadroparin Anticoagulation for Continuous Venovenous Hemofiltration (CVVH), a Randomized Cross-over Trial Comparing Hemostasis Between Two Hemofiltration Rates Completed NCT00965328 Phase 4
20 Heparin Versus Prostacyclin in Continuous Hemodiafiltration for Acute Renal Failure: Effects on Platelet Responsiveness in the Systemic Circulation and Across the Filter. Completed NCT00890214 Phase 4 prostacyclin;heparin
21 Multicentre, Unblinded, Open Label, Randomised, Controlled Trial to Assess the Effect of Augmented Vs. Normal Continuous Renal Replacement Therapy (CRRT) on 90-Day All-Cause Mortality of Intensive Care Unit Patients With Severe Acute Renal Failure (ARF). Completed NCT00221013 Phase 4
22 The Hannover-Dialysis-Outcome (HAN-D-OUT)-Study: Comparison of Standard Versus Intensified Extended Dialysis in Treatment of Patients With Acute Kidney Injury in the Intensive-Care Unit Completed NCT00529139 Phase 4
23 Pharmacokinetics of Invanz® (Ertapenem) in Critically Ill Patients Receiving Continuous Venovenous Hemodialysis Completed NCT00877370 Phase 4 ertapenem
24 Citrate-based Regional Anticoagulation Versus Heparin for Continuous Renal Replacement Therapy in Critically Ill Patients With Acute Renal Failure: a Randomized Controlled Trial Completed NCT01269112 Phase 4
25 Metabolic Pattern of Cyclosporine A - Association of Secondary- and Cyclic Metabolites With Acute Renal Failure in Heart Transplant Recipients Completed NCT00264355 Phase 4 cyclosporine A
26 Perioperative Evaluation of Terlipressin Infusion During Living Donor Liver Transplantation on Incidence of Acute Kidney Completed NCT02059460 Phase 4 Terlipressin;placebo
27 Effect of N-acetylcysteine on Prevention of Acute Kidney Injury in High Risk Patients Undergoing Off-pump Coronary Artery Bypass Graft Completed NCT01394419 Phase 4 N-acetylcysteine;Saline
28 Regional Citrate Versus Systemic Heparin Anticoagulation for Continuous Renal Replacement Therapy in Critically Ill Patients With Acute Kidney Injury Completed NCT02669589 Phase 4 Heparin;Citrate
29 The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery Completed NCT01920126 Phase 4 sodium bicarbonate;Saline
30 The Effect of Nafamostat Mesilate in Prolonging Filter Patency With Patients on Continuous Renal Replacement Therapy Completed NCT01761994 Phase 4 Anticoagulation with nafamostat mesilate
31 Early Hydration in Acute Myocardial Infarction: Sodium Bicarbonate Versus Saline for the Prevention on Contrast-induced Acute Kidney Injury Completed NCT01742130 Phase 4 sodium bicarbonate solution;Isotonic saline
32 Personalized Versus Standard Hydration for Prevention of Contrast Induced Acute Kidney Injury. A Randomized Trial With Bioimpedance Analysis. Completed NCT02225431 Phase 4 sodium chloride infusion
33 Preloading Magnesium Attenuate Cisplatin-induced Nephrotoxicity Completed NCT02481518 Phase 4 Magnesium
34 Trial to Assess the Efficacy and Safety of Nafamostat Mesilate During Continuous Renal Replacement Therapy Completed NCT02478242 Phase 4 Nafamostat mesilate;Normal saline
35 Pharmacokinetics of Antiepileptic Drugs in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy Completed NCT03632915 Phase 4 Levetiracetam;Lacosamide;Phenytoin;Phenobarbital;Ketamine;Valproic Acid
36 Effect of the Intensity of Continuous Renal Replacement Therapy in Patients With Cardiac Surgery Associated Acute Kidney Injury (CRITERIA STUDY) Completed NCT01560650 Phase 4
37 Effect of Aminophylline on Contrast Induced Acute Kidney Injury in Patients With Acute Myocardial Infarction Treated With Primary Angioplasty Completed NCT01594489 Phase 4 Aminophylline;Hydration plus N-acetylcisteine
38 The EUROpean and Asian Cardiac and Renal Remote Ischemic Pre-conditioning Study : A Prospective, Randomized Control Trial Completed NCT02195726 Phase 4
39 The Effect of Atorvastatin on Prevention of Postoperative Acute Kidney Injury in Patients Undergoing Aortic Surgery Completed NCT02157337 Phase 4 Atorvastatin;placebo
40 Impact of Early High-dose Atorvastatin Versus Rosuvastatin on Contrast Induced Acute Kidney Injury in Unselected Patients With Non- ST Elevation Acute Coronary Syndromes Scheduled for Early Invasive Strategy. Completed NCT01870804 Phase 4 Rosuvastatin;Atorvastatin
41 Prevention of Acute Kidney Injury by Erythropoietin in Patients Undergoing Thoracic Aorta Surgery With Hypothermic Cardiac Arrest Completed NCT01369732 Phase 4 recombinant human erythropoietin;saline
42 Reducing Acute Kidney Injury in TAVI Patients (REDUCE Trial) Completed NCT01866800 Phase 4 Conventional Treatment
43 Effect of Intraoperative Dexmedetomidine on Development of Acute Kidney Injury Following Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy: a Double-blind Randomized Clinical Trial Completed NCT02641938 Phase 4 Dexmedetomidine;Normal Saline
44 Multicenter Randomized Controlled Study of Rosuvastatin for Prevention of Contrast Induced Acute Kidney Injury in Patients With Diabetes and Slight to Moderate Renal Insufficient Completed NCT00786136 Phase 4 rosuvastatin
45 Fluid Mobilization in Hospitalized Patients With Acute Kidney Injury Completed NCT04522635 Phase 4 (100 ml of Albumin 25%)
46 Evaluation of Systemic Leakage When a Heparin or Citrate Lock is Injected and Biological and Clinical Repercussions: Ancillary Study of the VERROU-REA Randomized Controlled Trial Completed NCT02860299 Phase 4 citrate 4%;unfractionated heparin
47 Pharmacokinetics of Cidofovir During Continuous Venovenous Hemofiltration Completed NCT01866397 Phase 4
48 Sup-Icu RENal (SIREN) - a Sub-analysis of the Prospective SUP (Stress Ulcer Prophylaxis)-ICU Trial on the Risk of GI- Bleeding in ICU Patients Receiving Renal Replacement Therapy Completed NCT02718261 Phase 4 Pantoprazole;Saline 0.9% (matching placebo)
49 Minimizing cOntrast utiliZAtion With IVUS Guidance in coRonary angioplasTy: The MOZART Study Completed NCT01947335 Phase 4
50 Outcomes of the Use of Sodium Bicarbonate (8.4%) Solution as a Catheter Lock Solution as a Catheter Lock Solution to Prevent Hemodialysis Catheter Loss Due to Lumen Clot Formation Completed NCT03627884 Phase 4 Sodium Bicarbonate Catheter Lock Solution;Normal Saline Catheter Lock Solution

Search NIH Clinical Center for Acute Kidney Failure

Inferred drug relations via UMLS 71 / NDF-RT 51 :


Bumetanide
Ethacrynate Sodium
Ethacrynic Acid
Furosemide
Mannitol hexanitrate
torsemide

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Acute Kidney Failure cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Acute Kidney Failure:
AC607, mesenchymal stem cells for treatment of acute kidney injury
Adipose-derived mesenchymal stem cells for treatment of ischemic kidney injury
Human amniotic fluid stem cells for treatment of acute kidney injury
Mesenchymal stem cells in cisplatin-induced acute renal failure
Renal progenitor cells for treatment of acute kidney injury
Embryonic/Adult Cultured Cells Related to Acute Kidney Failure:
Bone marrow-derived mesenchymal stem cells (family) PMIDs: 20186233 19397783 20017833 19861311
Adipose-derived mesenchymal stem cells PMIDs: 22398959
Amniotic fluid stem cells PMIDs: 22060053 20724594
Bone marrow-derived mesenchymal stem cells PMIDs: 22060053 20724594
Parietal epithelial cells (PEC) PMIDs: 16885410 17978305
Renal embryonic cells (CD24+CD133+ REC) PMIDs: 16885410 17978305

Cochrane evidence based reviews: acute kidney injury

Sources

Genetic Tests for Acute Kidney Failure

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Sources

Anatomical Context for Acute Kidney Failure

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MalaCards organs/tissues related to Acute Kidney Failure:

40
Kidney, Liver, Neutrophil, Endothelial, Bone Marrow, Heart, Skin
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Acute Kidney Failure:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
2 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
3 Kidney Proximal Tubule Proximal Tubule Cells Affected by disease, potential therapeutic candidate
Sources

Publications for Acute Kidney Failure

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Articles related to Acute Kidney Failure:

(show top 50) (show all 23567)
# Title Authors PMID Year
1
Community acquired methicillin-resistant Staphylococcus aureus pneumonia leading to rhabdomyolysis: a case report. 54 61
20205915 2010
2
Tetanus as a cause of rhabdomyolysis and acute renal failure. 61 54
20040354 2010
3
Utility of urine myoglobin for the prediction of acute renal failure in patients with suspected rhabdomyolysis: a systematic review. 54 61
19797717 2009
4
Chickenpox: presentation and complications in adults. 61 54
20201174 2009
5
Serum neutrophil gelatinase-associated lipocalin correlates with kidney function in renal allograft recipients. 54 61
19708926 2009
6
Rhabdomyolysis and acute renal failure associated with the co-administration of daptomycin and an HMG-CoA reductase inhibitor. 54 61
19346518 2009
7
Tramadol overdose induced seizure, dramatic rise of CPK and acute renal failure. 61 54
19288949 2009
8
Aliskiren-associated acute renal failure with hyperkalemia. 61 54
19281746 2009
9
The role of stress-activated protein kinase signaling in renal pathophysiology. 54 61
18982195 2009
10
NGAL (neutrophil gelatinase-associated lipocalin) and L-FABP after percutaneous coronary interventions due to unstable angina in patients with normal serum creatinine. 54 61
19875355 2009
11
Neutrophil gelatinase-associated lipocalin and cystatin C could predict renal outcome in patients undergoing kidney allograft transplantation: a prospective study. 54 61
19249501 2009
12
[Rhabdomyolysis due to muscle enzyme deficiencies]. 61 54
19240776 2009
13
Early recognition of renal toxicity of high-dose methotrexate therapy: a case report. 54 61
19131789 2008
14
The syndrome of rhabdomyolysis: complications and treatment. 54 61
19046720 2008
15
[Rhabdomyolysis after laparoscopic nephrectomy: case report]. 54 61
18972919 2008
16
Acute renal failure due to rhabdomyolysis in a child with McArdle disease. 61 54
17899190 2008
17
Prognostic values of serum cystatin C and beta2 microglobulin, urinary beta2 microglobulin and N-acetyl-beta-D-glucosaminidase in early acute renal failure after liver transplantation. 54 61
18713542 2008
18
[Acute rhabdomyolysis: a case report and literature review]. 61 54
18843854 2008
19
Severe rhabdomyolysis with hypoglycemia in an adult patient with carnitine palmitoyltransferase II deficiency. 61 54
18471680 2008
20
Daptomycin-induced acute renal and hepatic toxicity without rhabdomyolysis. 61 54
18381844 2008
21
Novel HGPRT 293 A>G point mutation presenting as neonatal acute renal failure. 61 54
17934765 2008
22
Lesch-Nyhan syndrome presenting with acute renal failure in a 3-day-old newborn. 61 54
17701224 2008
23
Relationship of serum cystatin C with C-reactive protein and apolipoprotein A1 in patients on hemodialysis. 54 61
18704820 2008
24
Rifaximin does not induce toxin production or phage-mediated lysis of Shiga toxin-producing Escherichia coli. 54 61
17526759 2007
25
Acute respiratory failure in adult patients with dengue virus infection. 61 54
17620647 2007
26
Gabapentin-induced severe myopathy. 54 61
17565043 2007
27
Alteration in renal organic anion transporter 1 after ischemia/reperfusion in cadaveric renal allografts. 61 54
17312013 2007
28
HPRT deficiency in a two-month-old child presenting acute renal failure and gout with a new deletion of two bases in exon 3 of the HPRT gene. 54 61
17416296 2007
29
Genetic analysis of the complement factor H related 5 gene in haemolytic uraemic syndrome. 54 61
17000000 2007
30
[Case of fulminant type 1 diabetes mellitus complicated with acute renal failure treated with continuous hemodiafiltration]. 54 61
17315734 2007
31
Exertional rhabdomyolysis and acute renal failure in marathon runners. 54 61
17465608 2007
32
Prevention and treatment of infections in patients with cirrhosis. 54 61
17223498 2007
33
Could neutrophil-gelatinase-associated lipocalin and cystatin C predict the development of contrast-induced nephropathy after percutaneous coronary interventions in patients with stable angina and normal serum creatinine values? 54 61
17901710 2007
34
Interleukin-18 and the pathogenesis of inflammatory diseases. 54 61
17336692 2007
35
Clopidogrel-precipitated rhabdomyolysis in a stable heart transplant patient. 54 61
17200431 2007
36
Continuous low-dose human atrial natriuretic peptide promotes diuresis in oliguric patients after living donor liver transplantation. 61 54
17175340 2006
37
Access to the kidney transplant wait list. 54 61
16952294 2006
38
An adolescent girl with Meyer-Betz syndrome. 61 54
16328090 2006
39
A double-blinded, randomized, placebo-controlled trial of infliximab in subjects with active pulmonary sarcoidosis. 61 54
18038919 2006
40
Safety of paracentesis in inpatients. 54 61
16995339 2006
41
Analysis of morbidity in liver transplant recipients following human albumin supplementation: a retrospective pilot study. 54 61
17007153 2006
42
Rhabdomyolysis and acute renal failure associated with influenza virus type B infection. 61 54
16909056 2006
43
[Hepatocyte growth factor and kidney]. 61 54
17063438 2006
44
Novel compound heterozygote mutations (H234Q/R1206X) of the ADAMTS13 gene in an adult patient with Upshaw-Schulman syndrome showing predominant episodes of repeated acute renal failure. 54 61
16449289 2006
45
Which of the cardiac natriuretic peptides is most effective for the treatment of congestive heart failure, renal failure and cancer? 61 54
16487258 2006
46
Molecular, biochemical, and genetic characterization of a female patient with Lesch-Nyhan disease. 54 61
16343967 2006
47
Neutrophil-gelatinase-associated lipocalin and renal function after percutaneous coronary interventions. 54 61
16772710 2006
48
Severe secondary deficiency of von Willebrand factor-cleaving protease (ADAMTS13) in patients with sepsis-induced disseminated intravascular coagulation: its correlation with development of renal failure. 54 61
16189276 2006
49
Partial hypoxanthine-guanine phosphoribosyltransferase deficiency presenting as acute renal failure. 54 61
16240158 2005
50
Hemolytic uremic syndrome-associated Shiga toxins promote endothelial-cell secretion and impair ADAMTS13 cleavage of unusually large von Willebrand factor multimers. 54 61
16131569 2005
Sources

Variations for Acute Kidney Failure

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ClinVar genetic disease variations for Acute Kidney Failure:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 YARS1 NM_003680.3:c.611A>C SNV Uncertain significance 986742 1:33256836-33256836 1:32791235-32791235
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Expression for Acute Kidney Failure

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Search GEO for disease gene expression data for Acute Kidney Failure.
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Pathways for Acute Kidney Failure

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Pathways related to Acute Kidney Failure according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Uricosurics Pathway, Pharmacodynamics 60
9.7 SLC22A6 SLC22A12
Sources

GO Terms for Acute Kidney Failure

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Cellular components related to Acute Kidney Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.93 REN NPPA LCN2 IL18 HP HGF
2 extracellular exosome GO:0070062 9.73 SLC22A6 SLC22A12 PIK3C2A MB LCN2 HP
3 endoplasmic reticulum lumen GO:0005788 9.71 CST3 B2M ALB ADAMTS13
4 platelet alpha granule lumen GO:0031093 9.54 HGF EGF ALB
5 specific granule lumen GO:0035580 9.5 LCN2 HP B2M
6 extracellular space GO:0005615 9.44 REN NPPA LCN2 IL18 HP HGF
7 tertiary granule lumen GO:1904724 9.43 HP CST3 B2M

Biological processes related to Acute Kidney Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.56 SLC22A12 REN LCN2 B2M
2 positive regulation of cold-induced thermogenesis GO:0120162 9.33 LCN2 IL18 CPT2
3 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.13 IL18 HGF EGF
4 cellular protein metabolic process GO:0044267 8.92 NPPA CST3 B2M ALB

Molecular functions related to Acute Kidney Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enterobactin binding GO:1903981 8.62 LCN2 ALB
Sources

Sources for Acute Kidney Failure

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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