MCID: ACT003
MIFTS: 38

Acute Kidney Tubular Necrosis

Categories: Nephrological diseases

Aliases & Classifications for Acute Kidney Tubular Necrosis

MalaCards integrated aliases for Acute Kidney Tubular Necrosis:

Name: Acute Kidney Tubular Necrosis 12 15 73
Acute Tubular Necrosis 12 76
Acute Renal Failure with Lesion of Tubular Necrosis 12
Acute Renal Failure with Tubular Necrosis 12
Kidney Tubular Necrosis, Acute 44
Atn - Acute Tubular Necrosis 12
Tubular Necrosis Acute 55
Acute Tubule Necrosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12556
ICD10 33 N17.0
MeSH 44 D007683
NCIt 50 C34749
UMLS 73 C0022672

Summaries for Acute Kidney Tubular Necrosis

MalaCards based summary : Acute Kidney Tubular Necrosis, also known as acute tubular necrosis, is related to anuria and acute pyelonephritis. An important gene associated with Acute Kidney Tubular Necrosis is MB (Myoglobin). The drugs Mycophenolate mofetil and Mycophenolic acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and neutrophil, and related phenotypes are cardiovascular system and cellular

Wikipedia : 76 Acute tubular necrosis (ATN) is a medical condition involving the death of tubular epithelial cells that... more...

Related Diseases for Acute Kidney Tubular Necrosis

Diseases related to Acute Kidney Tubular Necrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 anuria 29.7 ALB LRSAM1 MB
2 acute pyelonephritis 29.5 ALB NAGLU
3 liver cirrhosis 29.5 ALB HGF NPPA
4 pyelonephritis 29.4 ALB NAGLU UMOD
5 hepatorenal syndrome 28.1 ALB CST3 IL18 NAGLU NPPA
6 hemoglobinuria 11.4
7 kidney cortex necrosis 11.1
8 diffuse meningeal melanocytosis 10.7 HGF TYR
9 spindle cell synovial sarcoma 10.6 HGF MB
10 endometrial squamous cell carcinoma 10.5 CDKN2A HGF
11 xanthinuria, type i 10.5 NAGLU UMOD
12 homocystinuria due to cystathionine beta-synthase deficiency 10.4 CST3 TYR
13 blackwater fever 10.4 CDKN2A LRSAM1
14 idiopathic hypercalciuria 10.3 NAGLU NPPA
15 burns 10.3 ALB HGF
16 syndrome of inappropriate antidiuretic hormone 10.3 ALB NPPA
17 compartment syndrome 10.2 ALB MB
18 central nervous system melanocytic neoplasm 10.2 CDKN2A HGF TYR
19 hypertensive nephropathy 10.2 ALB NAGLU
20 nephrolithiasis, calcium oxalate 10.1 NAGLU UMOD
21 polyposis, skin pigmentation, alopecia, and fingernail changes 10.1 ALB CABIN1
22 acute liver failure 10.1 ALB HGF
23 lipoid nephrosis 10.0 ALB NAGLU
24 interstitial nephritis 10.0
25 sialolithiasis 10.0 ALB HAVCR1
26 noma 9.9 ALB IL18
27 glomerulonephritis 9.9
28 urinary tract obstruction 9.9 ALB NAGLU UMOD
29 acute cystitis 9.9 ALB IL18
30 ischemia 9.8
31 bladder squamous cell carcinoma 9.7 CDKN2A HGF
32 focal segmental glomerulosclerosis 1 9.7
33 paroxysmal nocturnal hemoglobinuria 9.7
34 hyperphosphatemia 9.7
35 fanconi syndrome 9.7
36 nephrotic syndrome 9.7
37 thyroid crisis 9.7
38 rapidly progressive glomerulonephritis 9.7
39 proliferative glomerulonephritis 9.7
40 thyroiditis 9.7
41 macroglobulinemia 9.7
42 aminoaciduria 9.7
43 drug rash with eosinophilia and systemic symptoms 9.7
44 end stage renal failure 9.7 ALB CST3 UMOD
45 myeloma, multiple 9.7 ALB CDKN2A HGF
46 coronary artery anomaly 9.6 CDKN2A CST3 MB NPPA
47 chronic kidney failure 9.4 ALB CST3 NPPA UMOD
48 kidney disease 9.0 ALB CST3 NAGLU NPPA UMOD
49 myocardial infarction 9.0 ALB CST3 MB NPPA
50 acute kidney failure 8.2 ALB CST3 HGF IL18 MB NPPA

Graphical network of the top 20 diseases related to Acute Kidney Tubular Necrosis:



Diseases related to Acute Kidney Tubular Necrosis

Symptoms & Phenotypes for Acute Kidney Tubular Necrosis

MGI Mouse Phenotypes related to Acute Kidney Tubular Necrosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.76 CDKN2A CST3 HGF IL18 MB NAGLU
2 cellular MP:0005384 9.56 ALB CDKN2A HGF IL18 MB NAGLU
3 muscle MP:0005369 9.1 ALB CDKN2A CST3 IL18 MB NPPA

Drugs & Therapeutics for Acute Kidney Tubular Necrosis

Drugs for Acute Kidney Tubular Necrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 1,Phase 2 128794-94-5 5281078
2
Mycophenolic acid Approved Phase 4,Phase 1,Phase 2 24280-93-1 446541
3
Tacrolimus Approved, Investigational Phase 4,Phase 1,Phase 2 104987-11-3 445643 439492
4
Acetylcysteine Approved, Investigational Phase 4,Phase 3 616-91-1 12035
5
Iodine Approved, Investigational Phase 4 7553-56-2 807
6
Everolimus Approved Phase 4,Phase 2 159351-69-6 6442177
7
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2 22916-47-8 4189
8
Sirolimus Approved, Investigational Phase 4,Phase 2 53123-88-9 5284616 6436030 46835353
9
Benzocaine Approved, Investigational Phase 4,Phase 2 1994-09-7, 94-09-7 2337
10 tannic acid Approved, Nutraceutical Phase 4,Phase 2
11 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
12 Anti-Bacterial Agents Phase 4,Phase 1,Phase 2
13 Antibiotics, Antitubercular Phase 4,Phase 1,Phase 2
14 Immunosuppressive Agents Phase 4,Phase 1,Phase 2
15 Antilymphocyte Serum Phase 4,Phase 1,Phase 2
16 Antitubercular Agents Phase 4,Phase 1,Phase 2
17 Calcineurin Inhibitors Phase 4,Phase 1,Phase 2
18 Antidotes Phase 4,Phase 3
19 Antioxidants Phase 4,Phase 3,Phase 2
20 Antiviral Agents Phase 4,Phase 3
21 cadexomer iodine Phase 4
22 Expectorants Phase 4,Phase 3
23 N-monoacetylcystine Phase 4,Phase 3
24 Protective Agents Phase 4,Phase 3,Phase 2
25 Respiratory System Agents Phase 4,Phase 3
26 Antifungal Agents Phase 4,Phase 2
27 Cyclosporins Phase 4,Phase 2
28 Anesthetics Phase 4
29
Basiliximab Approved, Investigational Phase 1, Phase 2,Phase 2 152923-56-3, 179045-86-4
30
Prednisone Approved, Vet_approved Phase 1, Phase 2,Phase 2 53-03-2 5865
31
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
32
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
33
Abatacept Approved Phase 2 332348-12-6 10237
34
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2,Phase 1 77-92-9 311
35 Antibodies Phase 1, Phase 2,Phase 2
36 Antibodies, Monoclonal Phase 1, Phase 2,Phase 2
37 Immunoglobulins Phase 1, Phase 2,Phase 2
38 Pharmaceutical Solutions Phase 2
39 Dermatologic Agents Phase 2
40 Methylprednisolone acetate Phase 2
41 Methylprednisolone Hemisuccinate Phase 2
42 Prednisolone acetate Phase 2
43 Prednisolone hemisuccinate Phase 2
44 Prednisolone phosphate Phase 2
45 Antirheumatic Agents Phase 2,Not Applicable
46 Natriuretic Agents Phase 1, Phase 2
47 Natriuretic Peptide, Brain Phase 1, Phase 2
48 Citrate Nutraceutical Phase 2,Phase 1
49
Midodrine Approved Not Applicable 133163-28-7, 42794-76-3 4195
50
Octreotide Approved, Investigational Not Applicable 83150-76-9 383414 6400441

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Mechanisms for the Effect of Acetylcysteine on Renal Function After Exposure to Radiographic Contrast Material Completed NCT00558142 Phase 4 Acetylcysteine;Visipaque 320;Visipaque 320
2 Study Evaluating Two Different Sirolimus-based Immunosuppressive Regimens in Elderly Kidney Transplant Recipients Completed NCT00254709 Phase 4 Sirolimus
3 Improved Induction and Maintenance Immunosuppression in Kidney Transplantation Completed NCT00556933 Phase 4 rabbit anti-thymocyte globulin;mycophenolate mofetil;rabbit anti-thymocyte globulin;sirolimus;tacrolimus
4 Acute Renal Failure Trial Network (ATN) Study Completed NCT00076219 Phase 3
5 Efficacy of N-Acetylcysteine in Prevention of Post-Catheterization Contrast-Induced Nephropathy in Diabetic Patients With Chronic Kidney Disease Completed NCT00808795 Phase 3 N-acetylcysteine;Placebo
6 Vasodilators and Anti-Oxidant Therapy in Early ATN Withdrawn NCT00286403 Phase 2, Phase 3 Fenoldopam Mesylate and/or MESNA
7 Effect of BM-MSCs on Early Graft Function Recovery After DCD Kidney Transplant. Unknown status NCT02563366 Phase 1, Phase 2
8 Effect of BM-MSCs in DCD Kidney Transplantation Unknown status NCT02561767 Phase 1, Phase 2 Induction therapy (ATG or Basiliximab);Maintenance therapy (Low-dose CNI + MPA + steroids)
9 A Study of CSL112 in Adults With Moderate Renal Impairment and Acute Myocardial Infarction Completed NCT02742103 Phase 2
10 A Study to Assess the Efficacy and Safety of Alefacept in Kidney Transplant Recipients Completed NCT00617604 Phase 2 Alefacept;placebo;Tacrolimus;Mycophenolate Mofetil;Steroids
11 Pharmacodynamics, Efficacy and Safety of Basiliximab 40 or 80 mg in Combination With Ciclosporine Microemulsion or Everolimus, in Adult Low Risk de Novo Renal Transplant Recipients (IDEALE Study) Completed NCT01596062 Phase 2 Simulect®;Neoral®;Certican®;Myfortic®;Corticosteroids
12 Early Conversion From CNI to Belatacept in Renal Transplant Recipients With Delayed and Slow Graft Function Recruiting NCT01837043 Phase 2 Belatacept;Calcineurin Inhibitor
13 Study to Evaluate the Safety and Efficacy of the Renal Assist Device in Patients With Acute Renal Failure Terminated NCT00280072 Phase 2
14 Use of Nesiritide (BNP) in Kidney Function in Patients With Congestive Heart Failure (CHF) and Kidney Failure Terminated NCT00348556 Phase 1, Phase 2 Nesiritide
15 Efficacy Study of a Selective Cytopheretic Device (SCD) in Patients With Acute Kidney Injury Terminated NCT01400893 Phase 2
16 Safety Study of a Selective Cytopheric Device (SCD) in Patients With Acute Renal Failure Completed NCT01072682 Phase 1
17 Evaluation of Renal Blood Flow Using Contrast Enhanced Ultrasound for Differential Diagnosis of Acute Kidney Injury in Cirrhotic Patients: A Pilot Study Unknown status NCT02147470 Not Applicable Definity ultrasound contrast agent
18 Neutrophile Gelatinase Associated Lipocalin Evaluation in Septic Acute Kidney Injury Unknown status NCT01122225
19 Predictive Value of PIIINP and Urinary NGAL in Renal Function Recovery Completed NCT02889575
20 Sensitivity and Specificity of NGAL in an Emergency Room Population Completed NCT00786708
21 Paracetamol Effect on Oxidative Stress and Renal Function in Severe Malaria Completed NCT01641289 Not Applicable Paracetamol;No Paracetamol
22 Retrospective Analysis of Renal Prognosis in Patients With Chronic Kidney Disease Recruiting NCT03201406
23 Impact of the Composition of Packed Red Blood Cell Supernatant on Renal Dysfunction and Posttransfusion Immunomodulation Recruiting NCT02763410

Search NIH Clinical Center for Acute Kidney Tubular Necrosis

Cochrane evidence based reviews: kidney tubular necrosis, acute

Genetic Tests for Acute Kidney Tubular Necrosis

Anatomical Context for Acute Kidney Tubular Necrosis

MalaCards organs/tissues related to Acute Kidney Tubular Necrosis:

41
Kidney, Liver, Neutrophil, Heart, Brain, Thyroid

Publications for Acute Kidney Tubular Necrosis

Articles related to Acute Kidney Tubular Necrosis:

(show all 44)
# Title Authors Year
1
Circulating miR-21, miR-210 and miR-146a as potential biomarkers to differentiate acute tubular necrosis from hepatorenal syndrome in patients with liver cirrhosis: a pilot study. ( 29303765 )
2018
2
Human Alpha-1-Antitrypsin (hAAT) therapy reduces renal dysfunction and acute tubular necrosis in a murine model of bilateral kidney ischemia-reperfusion injury. ( 28235038 )
2017
3
Overexpression of Intrarenal Renin-Angiotensin System in Human Acute Tubular Necrosis. ( 27788506 )
2016
4
Acute tubular necrosis as a part of vancomycin induced drug rash with eosinophilia and systemic symptoms syndrome with coincident postinfectious glomerulonephritis. ( 27186222 )
2016
5
Association of soluble human leukocyte antigen-G with acute tubular necrosis in kidney transplant recipients. ( 26141032 )
2015
6
Acute tubular necrosis in a patient with paroxysmal nocturnal hemoglobinuria. ( 23354203 )
2013
7
Renal failure in cirrhosis: prerenal azotemia, hepatorenal syndrome and acute tubular necrosis. ( 22492830 )
2012
8
Drug-induced acute interstitial nephritis mimicking acute tubular necrosis after initiation of tenofovir-containing antiretroviral therapy in patient with HIV-1 infection. ( 22975570 )
2012
9
Biopsy-proven vancomycin-associated interstitial nephritis and acute tubular necrosis. ( 22086124 )
2012
10
Impact of the etiology of acute kidney injury on outcomes following liver transplantation: acute tubular necrosis versus hepatorenal syndrome. ( 22250075 )
2012
11
Nephrotic syndrome and acute tubular necrosis due to meloxicam use. ( 22963504 )
2012
12
Role of acute tubular necrosis with blood cast during endocapillary proliferative glomerulonephritis. ( 21959738 )
2011
13
Ga-67 scintigraphy in the differential diagnosis between acute interstitial nephritis and acute tubular necrosis: an experimental study. ( 20348147 )
2010
14
Challenges in clinical-pathologic correlations: acute tubular necrosis in a patient with collapsing focal and segmental glomerulosclerosis mimicking rapidly progressive glomerulonephritis. ( 20722570 )
2010
15
Adefovir dipivoxil-induced acute tubular necrosis and Fanconi syndrome in a renal transplant patient. ( 19165085 )
2009
16
Immunoglobulin M 'Flare' after rituximab-associated acute tubular necrosis in WaldenstrAPm's macroglobulinemia. ( 19156501 )
2009
17
Association of pretransplant soluble glycoprotein 130 (sgp130) plasma levels and posttransplant acute tubular necrosis in renal transplant recipients. ( 19623024 )
2009
18
Acute Tubular Necrosis and Interstitial Nephritis during Pemetrexed Therapy. ( 20740145 )
2009
19
Poly[ADP-ribose] polymerase-1 expression is related to cold ischemia, acute tubular necrosis, and delayed renal function in kidney transplantation. ( 19784367 )
2009
20
The L1 cell adhesion molecule is a potential biomarker of human distal nephron injury in acute tubular necrosis. ( 18059459 )
2008
21
Acute tubular necrosis after renal allograft segmental infarction: the nephrotoxicity of necrotic material. ( 19338495 )
2008
22
Possible mechanisms explaining the tendency towards interstitial fibrosis in aristolochic acid-induced acute tubular necrosis. ( 17124284 )
2007
23
[Are IL2 receptor antagonist useful in high risk acute tubular necrosis kidney recipients?]. ( 18045028 )
2007
24
Association of high pretransplant sIL-6R plasma levels with acute tubular necrosis in kidney graft recipients. ( 16794539 )
2006
25
Acute tubular necrosis is characterized by activation of the alternative pathway of complement. ( 15673300 )
2005
26
Role of poly-(ADP-ribose) polymerase in transplant acute tubular necrosis and its relationship with delayed renal function. ( 15866623 )
2005
27
Prognostic value of tubular proteinuria and enzymuria in nonoliguric acute tubular necrosis. ( 14709451 )
2004
28
Urinary interleukin-18 is a marker of human acute tubular necrosis. ( 14981598 )
2004
29
Acute tubular necrosis due to captopril. ( 10773617 )
2000
30
Urinary N-acetyl-beta-D-glucosaminidase and neopterin aid in the diagnosis of rejection and acute tubular necrosis in initially nonfunctioning kidney grafts. ( 10720893 )
2000
31
Update on clinical trials with atrial natriuretic peptide in acute tubular necrosis. ( 9768436 )
1998
32
Can pretransplantation hyperphosphatemia cause acute tubular necrosis in renal transplantation? ( 9838606 )
1998
33
Anaritide in acute tubular necrosis. Auriculin Anaritide Acute Renal Failure Study Group. ( 9062091 )
1997
34
Cause of acute tubular necrosis affects its prognosis. The Auriculin Anaritide Acute Renal Failure Study Group. ( 9290542 )
1997
35
Uromodulin levels are decreased in urine during acute tubular necrosis but not during immune rejection after renal transplantation. ( 8382589 )
1993
36
Plasma fibronectin levels during acute rejection and acute tubular necrosis in renal transplant patients. ( 1412724 )
1992
37
Clinical spectrum of accidental hemlock poisoning: neurotoxic manifestations, rhabdomyolysis and acute tubular necrosis. ( 1798593 )
1991
38
Acute tubular necrosis associated with acute pyelonephritis and concomitant diclofenac therapy. ( 3652539 )
1987
39
Urinary beta 2-microglobulin and serum bilirubin concentrations in hepatorenal syndrome and acute tubular necrosis. ( 3943786 )
1986
40
Acute tubular necrosis in hepatorenal syndrome: an electron microscopy study. ( 7148828 )
1982
41
D-serine nephrotoxicity. The nature of proteinuria, glucosuria, and aminoaciduria in acute tubular necrosis. ( 1203037 )
1975
42
Anuria and acute tubular necrosis associated with gentamicin and cephalothin. ( 4678426 )
1972
43
ACUTE TUBULAR NECROSIS CONSEQUENT TO ENCEPHALOMYOPATHIC THYROID CRISIS. ( 14136246 )
1964
44
Anuria ascribed to acute tubular necrosis in infancy and early childhood. ( 13395581 )
1956

Variations for Acute Kidney Tubular Necrosis

Expression for Acute Kidney Tubular Necrosis

Search GEO for disease gene expression data for Acute Kidney Tubular Necrosis.

Pathways for Acute Kidney Tubular Necrosis

GO Terms for Acute Kidney Tubular Necrosis

Biological processes related to Acute Kidney Tubular Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.13 ALB CST3 NPPA
2 response to hypoxia GO:0001666 8.8 CST3 MB NPPA

Sources for Acute Kidney Tubular Necrosis

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28 GO
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45 MESH via Orphanet
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
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74 UMLS via Orphanet
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