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MCID: ACT003
MIFTS: 44

Acute Kidney Tubular Necrosis

Categories: Nephrological diseases
Genes Tissues Related diseases Publications Drugs
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Aliases & Classifications for Acute Kidney Tubular Necrosis

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MalaCards integrated aliases for Acute Kidney Tubular Necrosis:

Name: Acute Kidney Tubular Necrosis 12 15 17 74
Acute Tubular Necrosis 12 77 15
Acute Renal Failure with Lesion of Tubular Necrosis 12
Acute Renal Failure with Tubular Necrosis 12
Kidney Tubular Necrosis, Acute 45
Atn - Acute Tubular Necrosis 12
Tubular Necrosis Acute 56
Acute Tubule Necrosis 12

Classifications:

MalaCards categories:
Anatomical: Nephrological diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:12556
MeSH 45 D007683
NCIt 51 C34749
SNOMED-CT 69 23697004 35455006
ICD10 34 N17.0
UMLS 74 C0022672
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Summaries for Acute Kidney Tubular Necrosis

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Disease Ontology : 12 An acute kidney failure that is characterized by necrosis of epithelial tubule cells.

MalaCards based summary : Acute Kidney Tubular Necrosis, also known as acute tubular necrosis, is related to metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration and lipoid nephrosis. An important gene associated with Acute Kidney Tubular Necrosis is MB (Myoglobin). The drugs Mycophenolic acid and Tacrolimus have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and neutrophil, and related phenotypes are cardiovascular system and cellular

Wikipedia : 77 Acute tubular necrosis (ATN) is a medical condition involving the death of tubular epithelial cells that... more...

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Related Diseases for Acute Kidney Tubular Necrosis

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Diseases related to Acute Kidney Tubular Necrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Related Disease Score Top Affiliating Genes
1 metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 30.6 MB PIK3C2A
2 lipoid nephrosis 30.1 ALB NAGLU
3 thyroid crisis 30.0 ALB MB
4 burns 30.0 ALB HGF
5 pyelonephritis 30.0 ALB NAGLU UMOD
6 liver cirrhosis 30.0 ALB HGF NPPA
7 acute pyelonephritis 29.7 ALB NAGLU
8 hepatorenal syndrome 29.7 ALB CST3 IL18 NPPA
9 anuria 29.6 ALB LRSAM1 MB PIK3C2A
10 end stage renal failure 29.5 ALB CST3 UMOD
11 chronic kidney failure 29.3 ALB CST3 NPPA UMOD
12 kidney disease 28.9 ALB CABIN1 CST3 NAGLU NPPA UMOD
13 acute kidney failure 28.0 ALB CST3 HGF IL18 MB NPPA
14 hemoglobinuria 11.6
15 kidney cortex necrosis 11.2
16 diffuse meningeal melanocytosis 10.3 HGF TYR
17 spindle cell synovial sarcoma 10.3 HGF MB
18 virus associated hemophagocytic syndrome 10.2 MB PIK3C2A
19 interstitial myocarditis 10.2 MB PIK3C2A
20 creatine phosphokinase, elevated serum 10.2 MB PIK3C2A
21 posterior myocardial infarction 10.2 MB PIK3C2A
22 myositis fibrosa 10.2 MB PIK3C2A
23 gas gangrene 10.2 MB PIK3C2A
24 xanthinuria, type i 10.2 NAGLU UMOD
25 syndrome of inappropriate antidiuretic hormone 10.2 ALB NPPA
26 neuroleptic malignant syndrome 10.2 MB PIK3C2A
27 plexopathy 10.2 MB PIK3C2A
28 glomerulonephritis 10.2
29 interstitial nephritis 10.2
30 ischemia 10.2
31 homocystinuria due to cystathionine beta-synthase deficiency 10.2 CST3 TYR
32 hypertensive nephropathy 10.2 ALB NAGLU
33 intermediate coronary syndrome 10.2 MB PIK3C2A
34 noma 10.1 ALB IL18
35 polyposis, skin pigmentation, alopecia, and fingernail changes 10.1 ALB CABIN1
36 idiopathic hypercalciuria 10.1 NAGLU NPPA
37 coronary artery anomaly 10.1 MB NPPA PIK3C2A
38 trichostrongyloidiasis 10.1 ALB PIK3C2A
39 acute myocardial infarction 10.1 MB NPPA PIK3C2A
40 anteroseptal myocardial infarction 10.1 ALB PIK3C2A
41 dengue virus 10.1
42 dengue disease 10.1
43 obstructive nephropathy 10.0 ALB HAVCR1 HGF
44 urinary tract obstruction 10.0 ALB NAGLU UMOD
45 endometrial squamous cell carcinoma 10.0 CDKN2A HGF
46 pericardium disease 10.0 ALB PIK3C2A
47 acute liver failure 10.0 ALB HGF
48 acute cystitis 10.0 ALB IL18
49 blackwater fever 10.0 CDKN2A LRSAM1
50 legionnaires' disease 10.0 ALB PIK3C2A

Graphical network of the top 20 diseases related to Acute Kidney Tubular Necrosis:



Diseases related to Acute Kidney Tubular Necrosis
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Symptoms & Phenotypes for Acute Kidney Tubular Necrosis

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MGI Mouse Phenotypes related to Acute Kidney Tubular Necrosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.06 CDKN2A CST3 HGF IL18 MB NAGLU
2 cellular MP:0005384 10.02 ALB CDKN2A HGF IL18 MB NAGLU
3 hematopoietic system MP:0005397 9.92 CABIN1 CDKN2A HGF IL18 MB NAGLU
4 homeostasis/metabolism MP:0005376 9.91 ALB CDKN2A CST3 IL18 MB NPPA
5 mortality/aging MP:0010768 9.85 ALB CABIN1 CDKN2A CST3 HGF IL18
6 muscle MP:0005369 9.43 ALB CDKN2A CST3 IL18 MB NPPA
7 renal/urinary system MP:0005367 9.1 ALB NAGLU NPPA PIK3C2A TYR UMOD
Sources

Drugs & Therapeutics for Acute Kidney Tubular Necrosis

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Drugs for Acute Kidney Tubular Necrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 76)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mycophenolic acid Approved Phase 4,Phase 1,Phase 2 24280-93-1 446541
2
Tacrolimus Approved, Investigational Phase 4,Phase 1,Phase 2 104987-11-3 445643 439492 6473866
3
Acetylcysteine Approved, Investigational Phase 4,Phase 3 616-91-1 12035
4
Iodine Approved, Investigational Phase 4 7553-56-2 807
5
Sirolimus Approved, Investigational Phase 4,Phase 2 53123-88-9 46835353 6436030 5284616
6
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2 22916-47-8 4189
7
Everolimus Approved Phase 4,Phase 2 159351-69-6 6442177 70789204
8
tannic acid Approved Phase 4,Phase 2 1401-55-4
9
Benzocaine Approved, Investigational Phase 4,Phase 2 94-09-7, 1994-09-7 2337
10
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
11 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
12 Immunosuppressive Agents Phase 4,Phase 1,Phase 2
13 Antibiotics, Antitubercular Phase 4,Phase 1,Phase 2
14 Anti-Bacterial Agents Phase 4,Phase 1,Phase 2
15 Immunologic Factors Phase 4,Phase 1,Phase 2
16 Cyclosporins Phase 4,Phase 2
17 Antitubercular Agents Phase 4,Phase 1,Phase 2
18 Calcineurin Inhibitors Phase 4,Phase 1,Phase 2
19 Antilymphocyte Serum Phase 4,Phase 1,Phase 2
20 Antidotes Phase 4,Phase 3
21 N-monoacetylcystine Phase 4,Phase 3
22 cadexomer iodine Phase 4
23 Antioxidants Phase 4,Phase 3,Phase 2
24 Expectorants Phase 4,Phase 3
25 Protective Agents Phase 4,Phase 3,Phase 2
26 Free Radical Scavengers Phase 4,Phase 3
27 Antiviral Agents Phase 4,Phase 3,Not Applicable
28 Respiratory System Agents Phase 4,Phase 3
29 Antifungal Agents Phase 4,Phase 2
30 Thymoglobulin Phase 4
31 Anesthetics Phase 4
32 diuretics Phase 4
33 Sodium Potassium Chloride Symporter Inhibitors Phase 4
34 Natriuretic Agents Phase 4,Phase 1,Phase 2
35
Prednisone Approved, Vet_approved Phase 1, Phase 2,Phase 2 53-03-2 5865
36
Basiliximab Approved, Investigational Phase 1, Phase 2,Phase 2 152923-56-3, 179045-86-4
37
Abatacept Approved Phase 2 332348-12-6 10237
38
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
39
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
40
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
41
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
42
Sodium Citrate Approved, Investigational Phase 2,Phase 1 68-04-2
43
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2,Phase 1 77-92-9 311
44
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
45 Antibodies Phase 1, Phase 2
46 Immunoglobulins Phase 1, Phase 2
47 Antirheumatic Agents Phase 2,Not Applicable
48 Pharmaceutical Solutions Phase 2
49 Dermatologic Agents Phase 2
50 Methylprednisolone Acetate Phase 2

Interventional clinical trials:

(show all 26)
# Name Status NCT ID Phase Drugs
1 Mechanisms for the Effect of Acetylcysteine on Renal Function After Exposure to Radiographic Contrast Material Completed NCT00558142 Phase 4 Acetylcysteine;Visipaque 320;Visipaque 320
2 Study Evaluating Two Different Sirolimus-based Immunosuppressive Regimens in Elderly Kidney Transplant Recipients Completed NCT00254709 Phase 4 Sirolimus
3 Improved Induction and Maintenance Immunosuppression in Kidney Transplantation Completed NCT00556933 Phase 4 rabbit anti-thymocyte globulin;mycophenolate mofetil;rabbit anti-thymocyte globulin;sirolimus;tacrolimus
4 FURosemide Stress Test to Predict Need of Renal Replacement THERapy in Ischemic Acute Tubular Necrosis in ICU Not yet recruiting NCT03731117 Phase 4 Furosemide
5 Acute Renal Failure Trial Network (ATN) Study Completed NCT00076219 Phase 3
6 Efficacy of N-Acetylcysteine in Prevention of Post-Catheterization Contrast-Induced Nephropathy in Diabetic Patients With Chronic Kidney Disease Completed NCT00808795 Phase 3 N-acetylcysteine;Placebo
7 Vasodilators and Anti-Oxidant Therapy in Early ATN Withdrawn NCT00286403 Phase 2, Phase 3 Fenoldopam Mesylate and/or MESNA
8 Effect of BM-MSCs on Early Graft Function Recovery After DCD Kidney Transplant. Unknown status NCT02563366 Phase 1, Phase 2
9 Effect of BM-MSCs in DCD Kidney Transplantation Unknown status NCT02561767 Phase 1, Phase 2 Induction therapy (ATG or Basiliximab);Maintenance therapy (Low-dose CNI + MPA + steroids)
10 Early Conversion From CNI to Belatacept in Renal Transplant Recipients With Delayed and Slow Graft Function Unknown status NCT01837043 Phase 2 Belatacept;Calcineurin Inhibitor
11 A Study of CSL112 in Adults With Moderate Renal Impairment and Acute Myocardial Infarction Completed NCT02742103 Phase 2
12 A Study to Assess the Efficacy and Safety of Alefacept in Kidney Transplant Recipients Completed NCT00617604 Phase 2 Alefacept;placebo;Tacrolimus;Mycophenolate Mofetil;Steroids
13 Pharmacodynamics, Efficacy and Safety of Basiliximab 40 or 80 mg in Combination With Ciclosporine Microemulsion or Everolimus, in Adult Low Risk de Novo Renal Transplant Recipients (IDEALE Study) Completed NCT01596062 Phase 2 Simulect®;Neoral®;Certican®;Myfortic®;Corticosteroids
14 Study to Evaluate the Safety and Efficacy of the Renal Assist Device in Patients With Acute Renal Failure Terminated NCT00280072 Phase 2
15 Use of Nesiritide (BNP) in Kidney Function in Patients With Congestive Heart Failure (CHF) and Kidney Failure Terminated NCT00348556 Phase 1, Phase 2 Nesiritide
16 Efficacy Study of a Selective Cytopheretic Device (SCD) in Patients With Acute Kidney Injury Terminated NCT01400893 Phase 2
17 Safety Study of a Selective Cytopheric Device (SCD) in Patients With Acute Renal Failure Completed NCT01072682 Phase 1
18 Evaluation of Renal Blood Flow Using Contrast Enhanced Ultrasound for Differential Diagnosis of Acute Kidney Injury in Cirrhotic Patients: A Pilot Study Unknown status NCT02147470 Not Applicable Definity ultrasound contrast agent
19 Neutrophile Gelatinase Associated Lipocalin Evaluation in Septic Acute Kidney Injury Unknown status NCT01122225
20 Predictive Value of PIIINP and Urinary NGAL in Renal Function Recovery Completed NCT02889575
21 Sensitivity and Specificity of NGAL in an Emergency Room Population Completed NCT00786708
22 Biomarkers NGAL, IL 18 as Predictors of Acute Kidney Injury in Renal Transplant Recipients Completed NCT03605264
23 Paracetamol Effect on Oxidative Stress and Renal Function in Severe Malaria Completed NCT01641289 Not Applicable Paracetamol;No Paracetamol
24 Retrospective Analysis of Renal Prognosis in Patients With Chronic Kidney Disease Recruiting NCT03201406
25 Impact of the Composition of Packed Red Blood Cell Supernatant on Renal Dysfunction and Posttransfusion Immunomodulation Recruiting NCT02763410
26 Renal Biopsy Unexplained Elevated Serum Creatinine Not yet recruiting NCT03586531

Search NIH Clinical Center for Acute Kidney Tubular Necrosis

Cochrane evidence based reviews: kidney tubular necrosis, acute

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Genetic Tests for Acute Kidney Tubular Necrosis

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Anatomical Context for Acute Kidney Tubular Necrosis

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MalaCards organs/tissues related to Acute Kidney Tubular Necrosis:

42
Kidney, Liver, Neutrophil, Brain, Heart, Testes, Bone
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Publications for Acute Kidney Tubular Necrosis

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Articles related to Acute Kidney Tubular Necrosis:

(show top 50) (show all 494)
# Title Authors Year
1
Utility of Basal Regional Oximetry Saturation for the Diagnosis of Acute Tubular Necrosis in the Early Postoperative Period Following Kidney Transplantation. ( 30879534 )
2019
2
Circulating miR-21, miR-210 and miR-146a as potential biomarkers to differentiate acute tubular necrosis from hepatorenal syndrome in patients with liver cirrhosis: a pilot study. ( 29303765 )
2018
3
Automated systematic random sampling and Cavalieri stereology of histologic sections demonstrating acute tubular necrosis after cardiac arrest and cardiopulmonary resuscitation in the mouse. ( 29901212 )
2018
4
Oral acyclovir induced hypokalemia and acute tubular necrosis a case report. ( 30428841 )
2018
5
Dapagliflozin as a cause of acute tubular necrosis with heavy consequences: a case report. ( 29127652 )
2018
6
The Rise and Fall of Acute Tubular Necrosis - An exercise in medical semiotics. ( 29482296 )
2018
7
Endothelin A Receptors Expressed in Renal Blood Vessels of Renal Transplant Patients Are Connected With Acute Tubular Necrosis or Antibody-Mediated Rejection. ( 30056896 )
2018
8
Histologically proven acute tubular necrosis in a series of 27 ICU patients. ( 30189356 )
2018
9
Immune mechanisms in the different phases of acute tubular necrosis. ( 30254843 )
2018
10
Interference With Coagulation Cascade as a Novel Approach to Counteract Cisplatin-Induced Acute Tubular Necrosis; an Experimental Study in Rats. ( 30364273 )
2018
11
Human Alpha-1-Antitrypsin (hAAT) therapy reduces renal dysfunction and acute tubular necrosis in a murine model of bilateral kidney ischemia-reperfusion injury. ( 28235038 )
2017
12
Rhabdomyolysis with acute tubular necrosis following occupational inhalation of thinners. ( 28486690 )
2017
13
Serum Lactate Dehydrogenase is Elevated in Ischemic Acute Tubular Necrosis but Not in Acute Rejection in Kidney Transplant Patients. ( 27555073 )
2017
14
Bmi-1 plays a critical role in the protection from acute tubular necrosis by mobilizing renal stem/progenitor cells. ( 27871857 )
2017
15
Urine Interleukin 18 and Lipocalin 2 Are Biomarkers of Acute Tubular Necrosis in Patients With Cirrhosis: A Systematic Review and Meta-analysis. ( 28013112 )
2017
16
Tubular Peroxiredoxin 3 as a Predictor of Renal Recovery from Acute Tubular Necrosis in Patients with Chronic Kidney Disease. ( 28240739 )
2017
17
The Impact of Kidney Disease on Acute Tubular Necrosis and Surgical Site Infection After Lumbar Fusion. ( 28552699 )
2017
18
Spontaneous Renal Allograft Rupture Caused by Acute Tubular Necrosis: A Case Report and Review of the Literature. ( 28808594 )
2017
19
Detection of Acute Tubular Necrosis Using Blood Oxygenation Level-Dependent (BOLD) MRI. ( 29197870 )
2017
20
Interobserver agreement for post mortem renal histopathology and diagnosis of acute tubular necrosis in critically ill patients. ( 29202260 )
2017
21
Acute tubular necrosis following transurethral resection of the Prostate using Glycine as irrigating fluid. ( 29424875 )
2017
22
Overexpression of Intrarenal Renin-Angiotensin System in Human Acute Tubular Necrosis. ( 27788506 )
2016
23
Acute tubular necrosis as a part of vancomycin induced drug rash with eosinophilia and systemic symptoms syndrome with coincident postinfectious glomerulonephritis. ( 27186222 )
2016
24
The effect of poly (ADP-ribose) polymerase inhibition on aminoglycoside-induced acute tubular necrosis in rats. ( 26951968 )
2016
25
Ischemic Acute Tubular Necrosis due to Diltiazem Overdose. ( 27150870 )
2016
26
Early onset acute tubular necrosis following single infusion of zoledronate. ( 27920815 )
2016
27
Acute Tubular Necrosis in a Patient With Myeloma Treated With Carfilzomib. ( 29142917 )
2016
28
Association of soluble human leukocyte antigen-G with acute tubular necrosis in kidney transplant recipients. ( 26141032 )
2015
29
End-stage renal disease attributed to acute tubular necrosis in the United States, 2001-2010. ( 25613997 )
2015
30
Microvascular inflammation and acute tubular necrosis are major histologic features of hantavirus nephropathy. ( 25791582 )
2015
31
Effect of bone marrow stem cell mobilisation on the expression levels of cellular growth factors in a rat model of acute tubular necrosis. ( 26622364 )
2015
32
Effects of autologous bone marrow-derived stem cell mobilization on acute tubular necrosis and cell apoptosis in rats. ( 26622404 )
2015
33
Oxaliplatin induced acute tubular necrosis. ( 26905139 )
2015
34
Biopsy proven acute tubular necrosis due to rhabdomyolysis in a dengue fever patient: a case report and review of literature. ( 24553615 )
2014
35
An unusual case of severe acute tubular necrosis. ( 24341664 )
2014
36
Preimplant histologic acute tubular necrosis and allograft outcomes. ( 24558049 )
2014
37
Power doppler sonography in early renal transplantation: does it differentiate acute graft rejection from acute tubular necrosis? ( 24969181 )
2014
38
Acute tubular necrosis and dengue. ( 25076432 )
2014
39
Prucalopride-associated acute tubular necrosis. ( 25133152 )
2014
40
Acute tubular necrosis (ATN) presenting with an unusually prolonged period of marked polyuria heralded by an abrupt oliguric phase. ( 25150229 )
2014
41
Vancomycin-induced acute tubular necrosis. ( 25228192 )
2014
42
Acute tubular necrosis after ingestion of a fertilizer containing sodium silicate. ( 25574406 )
2014
43
Severe acute tubular necrosis observed subsequent to oxaliplatin administration. ( 25859355 )
2014
44
Acute tubular necrosis in a patient with paroxysmal nocturnal hemoglobinuria. ( 23354203 )
2013
45
Masitinib-associated minimal change disease with acute tubular necrosis resulting in acute kidney injury in a dog. ( 24020652 )
2013
46
Bilirubin-associated acute tubular necrosis in a kidney transplant recipient. ( 23465956 )
2013
47
Acute tubular necrosis associated with mTOR inhibitor therapy: a real entity biopsy-proven. ( 23798615 )
2013
48
Preconditioning with triiodothyronine improves the clinical signs and acute tubular necrosis induced by ischemia/reperfusion in rats. ( 24086411 )
2013
49
Comparison of renal transplant scintigraphy with renal resistance index for prediction of early graft dysfunction and evaluation of acute tubular necrosis and acute rejection. ( 24152633 )
2013
50
Prolonged recovery time from zoledronic Acid induced acute tubular necrosis: a case report and review of the literature. ( 24527249 )
2013
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Variations for Acute Kidney Tubular Necrosis

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Expression for Acute Kidney Tubular Necrosis

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Search GEO for disease gene expression data for Acute Kidney Tubular Necrosis.
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Pathways for Acute Kidney Tubular Necrosis

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GO Terms for Acute Kidney Tubular Necrosis

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Biological processes related to Acute Kidney Tubular Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 8.8 ALB CST3 NPPA

Molecular functions related to Acute Kidney Tubular Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxygen binding GO:0019825 8.62 ALB MB
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Sources for Acute Kidney Tubular Necrosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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