MCID: ACT003
MIFTS: 46

Acute Kidney Tubular Necrosis

Categories: Nephrological diseases

Aliases & Classifications for Acute Kidney Tubular Necrosis

MalaCards integrated aliases for Acute Kidney Tubular Necrosis:

Name: Acute Kidney Tubular Necrosis 12 15 17 70
Acute Tubular Necrosis 12 73 15
Acute Renal Failure with Tubular Necrosis 12 32
Acute Renal Failure with Lesion of Tubular Necrosis 12
Kidney Tubular Necrosis, Acute 44
Atn - Acute Tubular Necrosis 12
Tubular Necrosis Acute 54
Acute Tubule Necrosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12556
MeSH 44 D007683
NCIt 50 C34749
SNOMED-CT 67 23697004
ICD10 32 N17.0
UMLS 70 C0022672

Summaries for Acute Kidney Tubular Necrosis

Disease Ontology : 12 An acute kidney failure that is characterized by necrosis of epithelial tubule cells.

MalaCards based summary : Acute Kidney Tubular Necrosis, also known as acute tubular necrosis, is related to ischemia and interstitial nephritis. An important gene associated with Acute Kidney Tubular Necrosis is MB (Myoglobin), and among its related pathways/superpathways are Folate Metabolism and Th1 Differentiation Pathway. The drugs Furosemide and Sodium Potassium Chloride Symporter Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and bone marrow, and related phenotypes are cardiovascular system and cellular

Wikipedia : 73 Acute tubular necrosis (ATN) is a medical condition involving the death of tubular epithelial cells that... more...

Related Diseases for Acute Kidney Tubular Necrosis

Diseases related to Acute Kidney Tubular Necrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 528)
# Related Disease Score Top Affiliating Genes
1 ischemia 30.7 PIK3C2A MB HGF ACE
2 interstitial nephritis 30.7 UMOD REN HAVCR1 B2M ALB ACE
3 glomerulonephritis 30.6 LRP2 LCN2 B2M ALB ACE
4 renal fibrosis 30.5 TNF REN HGF ALB
5 urinary tract infection 30.4 UMOD LCN2 ACE
6 acute kidney failure 30.4 UMOD REN PIK3C2A NPPA MB LCN2
7 proteinuria, chronic benign 30.4 REN NAGLU LRP2 B2M ALB ACE
8 glomerular disease 30.3 NAGLU ALB ACE
9 iga glomerulonephritis 30.3 REN NAGLU IL6 ALB ACE
10 hepatorenal syndrome 30.2 REN NPPA NAGLU LCN2 IL18 CST3
11 hepatitis a 30.2 TNF HAVCR1 ALB
12 cardiogenic shock 30.2 TNF IL6
13 hypokalemia 30.1 REN ALB ACE
14 peptic esophagitis 30.1 TNF IL6 ALB
15 scrub typhus 30.1 TNF LCN2 IL18 HAVCR1
16 perinatal necrotizing enterocolitis 30.1 TNF IL6 ALB
17 dengue hemorrhagic fever 30.0 TNF IL6 ALB
18 typhoid fever 30.0 TNF IL6 ALB
19 iron deficiency anemia 30.0 TNF MB LCN2 IL6
20 chorioamnionitis 30.0 TNF IL6 IL18
21 anuria 30.0 REN PIK3C2A MB LCN2 HAVCR1 CST3
22 hepatic encephalopathy 30.0 TNF IL6 IL18 ALB
23 focal segmental glomerulosclerosis 29.9 TNF LCN2 IL6 ALB ACE
24 cardiac arrest 29.9 REN PIK3C2A LCN2 ALB ACE
25 gastroenteritis 29.9 TNF REN IL6 ALB
26 endocarditis 29.9 TNF PIK3C2A IL6 ALB
27 acute pyelonephritis 29.9 NAGLU LCN2 IL6 ALB ACE
28 exanthem 29.9 TNF PIK3C2A IL6 IL18 ALB ACE
29 sickle cell anemia 29.9 TNF IL6 ALB ACE
30 cystitis 29.8 UMOD TNF IL6 IL18 CST3
31 alcoholic hepatitis 29.8 TNF IL6 IL18 HGF ALB
32 liver cirrhosis 29.8 TNF REN NPPA IL6 HGF CST3
33 end stage renal disease 29.7 UMOD TNF REN IL6 HAVCR1 CST3
34 peritonitis 29.7 TNF IL6 IL18 B2M ALB
35 pericardial effusion 29.7 REN PIK3C2A NPPA IL6 ALB ACE
36 fanconi syndrome 29.7 UMOD OGA NAGLU LRP2 B2M ALB
37 pyelonephritis 29.6 UMOD TNF NAGLU LCN2 IL6 ALB
38 myeloma, multiple 29.6 TNF MIR142 IL6 B2M ALB
39 compartment syndrome 29.6 TNF PIK3C2A MB LCN2 IL6 ALB
40 pheochromocytoma 29.6 TNF REN NPPA IL6 ACE
41 respiratory failure 29.6 TNF REN PIK3C2A NPPA IL6 ALB
42 urinary tract obstruction 29.5 UMOD REN NAGLU MIR142 LCN2 HAVCR1
43 osteoporosis 29.3 TNF IL6 IL18 CST3 B2M ALB
44 nephrotic syndrome 29.2 TNF REN NPPA NAGLU LRP2 IL6
45 malaria 29.2 TNF MB LCN2 IL6 IL18 B2M
46 deficiency anemia 29.1 TNF NPPA MB LCN2 IL6 CST3
47 kidney disease 29.0 UMOD TNF REN NPPA NAGLU LRP2
48 chronic kidney disease 28.7 UMOD TNF REN NPPA LCN2 IL6
49 hemoglobinuria 11.2
50 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.5

Graphical network of the top 20 diseases related to Acute Kidney Tubular Necrosis:



Diseases related to Acute Kidney Tubular Necrosis

Symptoms & Phenotypes for Acute Kidney Tubular Necrosis

MGI Mouse Phenotypes related to Acute Kidney Tubular Necrosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.38 ACE ALB B2M CST3 HGF IL18
2 cellular MP:0005384 10.3 ALB B2M CST3 HGF IL18 IL6
3 growth/size/body region MP:0005378 10.28 ACE B2M HGF IL18 IL6 LCN2
4 hematopoietic system MP:0005397 10.25 ACE B2M FABP1 HGF IL18 IL6
5 homeostasis/metabolism MP:0005376 10.24 ACE ALB B2M CST3 FABP1 IL18
6 immune system MP:0005387 10.13 ACE ALB B2M FABP1 IL18 IL6
7 mortality/aging MP:0010768 10.03 ACE ALB B2M CST3 HGF IL18
8 liver/biliary system MP:0005370 9.91 ACE ALB B2M FABP1 HGF IL6
9 muscle MP:0005369 9.56 ALB CST3 IL18 IL6 MB NPPA
10 renal/urinary system MP:0005367 9.32 ACE ALB IL6 LCN2 LRP2 NAGLU

Drugs & Therapeutics for Acute Kidney Tubular Necrosis

Drugs for Acute Kidney Tubular Necrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
2 Sodium Potassium Chloride Symporter Inhibitors Phase 4
3 diuretics Phase 4
4
Prednisone Approved, Vet_approved Phase 1, Phase 2 53-03-2 5865
5
Tacrolimus Approved, Investigational Phase 1, Phase 2 104987-11-3 6473866 445643 439492
6
Basiliximab Approved, Investigational Phase 1, Phase 2 152923-56-3, 179045-86-4
7
Mycophenolic acid Approved Phase 1, Phase 2 24280-93-1 446541
8 Antibiotics, Antitubercular Phase 1, Phase 2
9 Immunosuppressive Agents Phase 1, Phase 2
10 Antibodies Phase 1, Phase 2
11 Immunologic Factors Phase 1, Phase 2
12 Immunoglobulins Phase 1, Phase 2
13 Anti-Bacterial Agents Phase 1, Phase 2
14 Antitubercular Agents Phase 1, Phase 2
15 Calcineurin Inhibitors Phase 1, Phase 2
16 Antilymphocyte Serum Phase 1, Phase 2
17 Anti-Infective Agents Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 FURosemide Stress Test to Predict Need of Renal Replacement THERapy in Ischemic Acute Tubular Necrosis in ICU Terminated NCT03731117 Phase 4 Furosemide
2 Effect of Bone Marrow-derived Mesenchymal Stem Cells (BM-MSCs) on Recovery of Poor Early Graft Function Post Kidney Transplantation From Chinese Donation After Citizen Death (DCD): A Multi-center Randomized Controlled Trial Unknown status NCT02563366 Phase 1, Phase 2
3 The Efficacy and Safety of Bone Marrow-derived Mesenchymal Stem Cells in Kidney Transplantation From Chinese Donation After Citizen Death (DCD): A Multi-center Randomized Controlled Trial Unknown status NCT02561767 Phase 1, Phase 2 Induction therapy (ATG or Basiliximab);Maintenance therapy (Low-dose CNI + MPA + steroids)
4 Phase I Clinical Trial, Dose-escalating Intra-aortic Infusion of Allogeneic , Bone Marrow-derived Multipotent Stromal Cells to Prevent and Treat Post-operative Acute Kidney Injury in Patients Who Require On-pump Cardiac Surgery Completed NCT00733876 Phase 1
5 Prospective Multicenter Study to Assess the Predictive Value of PIIINP and Urinary NGAL in Renal Function Recovery During Acute Tubular Necrosis Completed NCT02889575

Search NIH Clinical Center for Acute Kidney Tubular Necrosis

Cochrane evidence based reviews: kidney tubular necrosis, acute

Genetic Tests for Acute Kidney Tubular Necrosis

Anatomical Context for Acute Kidney Tubular Necrosis

MalaCards organs/tissues related to Acute Kidney Tubular Necrosis:

40
Kidney, Liver, Bone Marrow, Bone, Heart, Endothelial, Neutrophil

Publications for Acute Kidney Tubular Necrosis

Articles related to Acute Kidney Tubular Necrosis:

(show top 50) (show all 3373)
# Title Authors PMID Year
1
Atrial natriuretic peptide enhances recovery from ischemia/reperfusion-induced renal injury in rats. 61 54
20471588 2010
2
Atrial natriuretic peptide attenuates ischemia/reperfusion-induced renal injury by reducing neutrophil activation in rats. 61 54
18648186 2008
3
Paraphenylene diamine ingestion: an uncommon cause of acute renal failure. 54 61
17699992 2007
4
Evaluation of hepatocyte growth factor as a sensitive marker for early detection of acute renal allograft rejection. 61 54
17452892 2007
5
Acute renal failure following kidney transplantation associated with myoglobinuria in patients treated with rapamycin. 61 54
16969287 2006
6
[Diagnosis and treatment of 23 cases with rhabdomyolysis related acute renal failure]. 54 61
12857462 2003
7
Role of polymeric Tamm-Horsfall protein in cast formation: oligosaccharide and tubular fluid ions. 61 54
11231348 2001
8
Atrial natriuretic factor in oliguric acute renal failure. Anaritide Acute Renal Failure Study Group. 61 54
11007679 2000
9
Urinary N-acetyl-beta-D-glucosaminidase and neopterin aid in the diagnosis of rejection and acute tubular necrosis in initially nonfunctioning kidney grafts. 61 54
10720893 2000
10
Update on clinical trials with atrial natriuretic peptide in acute tubular necrosis. 61 54
9768436 1998
11
The rise and fall of atrial natriuretic peptide for acute renal failure. 54 61
9327207 1997
12
Diagnostic value of urinary enzyme determination in renal transplantation. 54 61
8959794 1996
13
Effect of 1-28 alpha-h atrial natriuretic peptide on acute renal failure in cadaveric renal transplantation. 54 61
8645892 1995
14
Marked enzymuria after bone marrow transplantation: a correlate of veno-occlusive disease-induced "hepatorenal syndrome". 61 54
8749694 1995
15
[Growth factors in tubular cells]. 61 54
7563623 1995
16
Uromodulin levels are decreased in urine during acute tubular necrosis but not during immune rejection after renal transplantation. 61 54
8382589 1993
17
Acute renal failure in bone marrow transplantation. 61 54
1437667 1992
18
Rhabdomyolysis associated with cocaine abuse. 61 54
1743698 1991
19
Atrial natriuretic factor does not improve the outcome of cadaveric renal transplantation. 54 61
1832982 1991
20
Rhabdomyolysis-induced acute renal failure in a child: a case report. 61 54
2259194 1990
21
15-Hydroxyprostaglandin dehydrogenase inhibitor prevents contrast-induced acute kidney injury. 61
33459127 2021
22
Grafts With Multiple Renal Arteries in Kidney Transplantation. 61
32950261 2021
23
[Therapeutics for acute tubular necrosis in 2020]. 61
33483244 2021
24
Thrombotic microangiopathy led to acute kidney injury in an infant with hemophagocytic lymphohistiocytosis: A case report. 61
33680118 2021
25
A rare case of acute tubular necrosis tenofovir alafenamide-related. 61
33749582 2021
26
Cocaine nephropathy: A rare cause of abnormal nephrograms. 61
33510825 2021
27
Emergence and molecular characterization of pigeon Paramyxovirus-1 in non-native Eurasian collared doves (Streptopelia decaocto) in California, USA. 61
33727141 2021
28
Atypical hemolytic uremic syndrome and acute tubular necrosis induced by complement factor B gene (CFB) mutation: A case report. 61
33725982 2021
29
Kidney biopsy findings in vancomycin-induced acute kidney injury: a pooled analysis. 61
33715061 2021
30
Renal involvement in Mediterranean spotted fever - clinical and histopathological data. 61
33780958 2021
31
Gene deficiency or pharmacological inhibition of PDCD4-mediated FGR signaling protects against acute kidney injury. 61
33643819 2021
32
Embolic Characteristics of Imipenem-Cilastatin Particles in Vitro and in Vivo: Implications for Transarterial Embolization in Joint Arthropathies. 61
33607251 2021
33
Outcomes of Delayed Graft Function in Kidney Transplant Recipients Stratified by Histologic Biopsy Findings. 61
33579551 2021
34
MicroRNAs: small molecules, big effects. 61
33278152 2021
35
Post-mortem Histopathologic Findings of Vital Organs in Critically Ill Patients with COVID-19. 61
33636984 2021
36
Recovery of kidney function after dialysis initiation in children and adults in the US: A retrospective study of United States Renal Data System data. 61
33606673 2021
37
Acute kidney injury and renal tubular damage in children with type 1 diabetes mellitus onset. 61
33595665 2021
38
Renal failure and hepatitis following ingestion of raw grass carp gallbladder: A case report. 61
33585643 2021
39
Concomitant nephrotic syndrome and tubulointerstitial nephritis in a child with Epstein-Barr virus mononucleosis. 61
33541950 2021
40
Role of Damage-Associated Molecular Patterns in Septic Acute Kidney Injury, From Injury to Recovery. 61
33732235 2021
41
Acute kidney injury induced by glycerol is worsened by orchiectomy and attenuated by testosterone replacement. 61
33171132 2021
42
Silence of Long Noncoding RNA SNHG14 Alleviates Ischemia/Reperfusion-Induced Acute Kidney Injury by Regulating miR-124-3p/MMP2 Axis. 61
33490282 2021
43
Imaging in Renal Transplants: An Update. 61
33485623 2021
44
[Acute renal failure of the donor in encephalic death: A real contraindication to kidney transplantation?] 61
33478867 2021
45
Comparison of Centrifugal and Pulsatile Perfusion to Preserve Donor Kidneys Using Ex Vivo Subnormothermic Perfusion. 61
33400888 2021
46
Success Rate of Grafts With Multiple Renal Vessels in 3136 Kidney Transplants. 61
32967599 2021
47
Retrospective Analysis of the Comparison Between Single Renal Artery Versus Multiple Renal Arteries in Living Donor Kidney Transplant: Does It Affect the Outcome? 61
33272157 2021
48
Hepatorenal Syndrome: Pathophysiology and evidence-based management update. 61
33544554 2021
49
Unusual case of polyarthritis and hepatorenal syndrome associated with Leptospira interrogans infection in a dog: A case report. 61
33388616 2021
50
[Acute kidney failure in patients admitted due to COVID-19]. 61
33162225 2021

Variations for Acute Kidney Tubular Necrosis

Expression for Acute Kidney Tubular Necrosis

Search GEO for disease gene expression data for Acute Kidney Tubular Necrosis.

Pathways for Acute Kidney Tubular Necrosis

Pathways related to Acute Kidney Tubular Necrosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.07 TNF LRP2 IL6 ALB
2
Show member pathways
11.53 TNF IL6 IL18
3 11.47 REN NPPA ACE
4 11.41 TNF LCN2 IL6 IL18 HGF
5 11.38 TNF IL6 HGF
6 11.3 TNF IL6 IL18
7 11.19 TNF IL6 IL18
8 11.16 TNF IL6 IL18 HGF
9 10.94 TNF IL6 IL18
10 10.49 TNF NPPA IL6 IL18

GO Terms for Acute Kidney Tubular Necrosis

Cellular components related to Acute Kidney Tubular Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.9 UMOD PIK3C2A NAGLU MB LRP2 LCN2
2 extracellular region GO:0005576 9.73 UMOD TNF REN NPPA LCN2 IL6
3 extracellular space GO:0005615 9.44 UMOD TNF REN NPPA MIR142 LCN2

Biological processes related to Acute Kidney Tubular Necrosis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.72 TNF IL6 IL18
2 cellular response to hydrogen peroxide GO:0070301 9.69 LCN2 IL6 FABP1
3 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.67 TNF HGF FABP1
4 positive regulation of protein kinase B signaling GO:0051897 9.67 TNF LRP2 IL18 HGF
5 regulation of blood pressure GO:0008217 9.65 REN NPPA ACE
6 cytokine-mediated signaling pathway GO:0019221 9.65 TNF LCN2 IL6 IL18 HGF
7 kidney development GO:0001822 9.62 UMOD REN LRP2 ACE
8 positive regulation of smooth muscle cell proliferation GO:0048661 9.61 TNF IL6 IL18
9 angiotensin maturation GO:0002003 9.57 REN ACE
10 neutrophil mediated immunity GO:0002446 9.56 IL6 ACE
11 cellular response to nicotine GO:0071316 9.54 TNF B2M
12 negative regulation of lipid storage GO:0010888 9.52 TNF IL6
13 negative regulation of bicellular tight junction assembly GO:1903347 9.46 TNF MIR142
14 vascular endothelial growth factor production GO:0010573 9.4 TNF IL6
15 cellular protein metabolic process GO:0044267 9.35 NPPA IL6 CST3 B2M ALB
16 negative regulation of neurogenesis GO:0050768 9.33 TNF IL6 B2M
17 positive regulation of neuroinflammatory response GO:0150078 8.92 TNF MIR142 IL6 IL18

Molecular functions related to Acute Kidney Tubular Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enterobactin binding GO:1903981 8.62 LCN2 ALB

Sources for Acute Kidney Tubular Necrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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