MCID: ACT003
MIFTS: 46

Acute Kidney Tubular Necrosis

Categories: Nephrological diseases
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Aliases & Classifications for Acute Kidney Tubular Necrosis

MalaCards integrated aliases for Acute Kidney Tubular Necrosis:

Name: Acute Kidney Tubular Necrosis 11 14 16 71
Acute Tubular Necrosis 11 75 14 33
Acute Renal Failure with Tubular Necrosis 11 31
Acute Tubule Necrosis 11 33
Acute Renal Failure with Lesion of Tubular Necrosis 11
Ischaemic Acute Tubular Necrosis 33
Kidney Tubular Necrosis, Acute 43
Atn - Acute Tubular Necrosis 11
Acute Renal Tubular Necrosis 33
Ischaemic Tubular Necrosis 33
Necrotising Renal Oedema 33
Acute Tubular Nephrosis 33
Kidney Tubular Necrosis 33
Lower Nephron Nephrosis 33
Tubular Kidney Necrosis 33
Tubular Necrosis Acute 53
Renal Tubular Necrosis 33
Toxic Tubular Necrosis 33
Tubular Necrosis Nos 33
Tubular Nephrosis 33

Classifications:



External Ids:

Disease Ontology 11 DOID:12556
MeSH 43 D007683
NCIt 49 C34749
SNOMED-CT 68 23697004
ICD10 31 N17.0
ICD11 33 867449270
UMLS 71 C0022672

Summaries for Acute Kidney Tubular Necrosis

Disease Ontology: 11 An acute kidney failure that is characterized by necrosis of epithelial tubule cells.

MalaCards based summary: Acute Kidney Tubular Necrosis, also known as acute tubular necrosis, is related to lipoid nephrosis and renal fibrosis. An important gene associated with Acute Kidney Tubular Necrosis is MB (Myoglobin), and among its related pathways/superpathways are Metabolism of proteins and Interleukin-4 and Interleukin-13 signaling. The drugs Furosemide and Sodium Potassium Chloride Symporter Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone marrow and bone, and related phenotypes are homeostasis/metabolism and growth/size/body region

Wikipedia: 75 Acute tubular necrosis (ATN) is a medical condition involving the death of tubular epithelial cells that... more...

Related Diseases for Acute Kidney Tubular Necrosis

Diseases related to Acute Kidney Tubular Necrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 516)
# Related Disease Score Top Affiliating Genes
1 lipoid nephrosis 30.9 NAGLU APOL1 ALB
2 renal fibrosis 30.7 REN IL18 HGF ALB
3 acute kidney failure 30.7 UMOD REN NPPA MB LCN2 IL6
4 dengue disease 30.6 IL6 CCR6 ALB
5 ischemia 30.6 MB IL6 HGF ACE
6 eclampsia 30.6 REN IL6 ALB ACE
7 uremia 30.6 REN IL6 ALB ACE
8 liver cirrhosis 30.6 REN NPPA IL6 HGF ALB
9 iga glomerulonephritis 30.5 REN IL6 CCR6 ALB ACE
10 glomerulonephritis 30.3 REN LRP2 LCN2 IL6 APOL1 ALB
11 endocarditis 30.3 LCN2 IL6 ALB
12 scrub typhus 30.3 LCN2 IL18 HAVCR1
13 salmonellosis 30.3 IL6 IL18 CCR6
14 rapidly progressive glomerulonephritis 30.3 REN ALB ACE
15 exanthem 30.3 IL6 IL18 CCR6 ALB ACE
16 peptic esophagitis 30.3 IL6 CCR6 ALB
17 hepatorenal syndrome 30.3 REN NPPA NAGLU LCN2 IL18 HAVCR1
18 interstitial nephritis 30.3 UMOD REN OGA LCN2 HAVCR1 CST3
19 pneumocystosis 30.2 IL6 CCR6 ALB
20 chronic pyelonephritis 30.2 UMOD REN ALB ACE
21 compartment syndrome 30.2 MB LCN2 IL6 ALB
22 dengue hemorrhagic fever 30.2 IL6 CCR6 ALB
23 pulmonary edema 30.2 REN NPPA HGF ACE
24 perinatal necrotizing enterocolitis 30.2 IL6 CCR6 ALB
25 renal artery atheroma 30.2 REN CST3 ALB ACE
26 hypokalemia 30.2 REN MB ALB ACE
27 alcoholic hepatitis 30.2 IL6 HGF ALB
28 typhoid fever 30.2 IL6 CCR6 ALB
29 hyperuricemia 30.2 UMOD REN LCN2 HAVCR1 ALB
30 hepatic encephalopathy 30.2 NPPA IL6 IL18 ALB
31 gout 30.2 UMOD IL6 IL18 ALB
32 common cold 30.2 IL6 CCR6 ACE2
33 deficiency anemia 30.2 REN MB IL6 CCR6 ALB ACE
34 peritonitis 30.1 LCN2 IL6 IL18 ALB
35 toxic encephalopathy 30.1 IL6 CCR6 ALB
36 gastroenteritis 30.1 REN IL6 ALB
37 leprosy 3 30.1 IL6 IL18 CCR6 ALB
38 pyelonephritis 30.1 UMOD NAGLU LCN2 IL6 ALB ACE
39 henoch-schoenlein purpura 30.1 IL6 CCR6 ALB ACE
40 substance abuse 30.1 IL6 CCR6 ALB ACE
41 anuria 30.1 REN MB LCN2 IGFBP7 HAVCR1 CST3
42 lipid metabolism disorder 30.1 REN MB IL6 CCR6 ALB ACE
43 pre-eclampsia 30.0 REN NPPA IL6 IL18 CST3 ALB
44 pheochromocytoma 29.9 REN NPPA IL6 HGF ACE
45 osteoporosis 29.9 IL6 IL18 HGF CST3 ALB ACE2
46 acute pyelonephritis 29.9 OGA NAGLU LCN2 IL6 HAVCR1 ALB
47 danubian endemic familial nephropathy 29.9 OGA LCN2 IL6 IL18 CST3 ALB
48 chronic kidney disease 29.9 UMOD REN NPPA LCN2 IL6 HGF
49 congestive heart failure 29.9 REN NPPA IL6 ALB ACE2 ACE
50 sickle cell anemia 29.8 IL6 APOL1 ALB

Graphical network of the top 20 diseases related to Acute Kidney Tubular Necrosis:



Diseases related to Acute Kidney Tubular Necrosis

Symptoms & Phenotypes for Acute Kidney Tubular Necrosis

GenomeRNAi Phenotypes related to Acute Kidney Tubular Necrosis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.19 ACE ACE2 ALB APOL1 CCR6 CST3
2 no effect GR00402-S-2 10.19 ACE ALB APOL1 CCR6 FABP1 HAVCR1

MGI Mouse Phenotypes related to Acute Kidney Tubular Necrosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.25 ACE ACE2 ALB CCR6 CST3 FABP1
2 growth/size/body region MP:0005378 10.21 ACE ACE2 HAVCR1 HGF IGFBP7 IL18
3 cellular MP:0005384 10.17 ACE ACE2 ALB CST3 HGF IGFBP7
4 renal/urinary system MP:0005367 10.16 ACE ACE2 ALB IL6 LCN2 LRP2
5 cardiovascular system MP:0005385 10.16 ACE ACE2 ALB APOL1 CCR6 CST3
6 muscle MP:0005369 10.03 ACE2 ALB CST3 IL18 IL6 MB
7 immune system MP:0005387 9.97 ACE ACE2 ALB CCR6 FABP1 HAVCR1
8 hematopoietic system MP:0005397 9.8 ACE ACE2 CCR6 FABP1 HAVCR1 HGF
9 mortality/aging MP:0010768 9.47 ACE ACE2 ALB CST3 HAVCR1 HGF

Drugs & Therapeutics for Acute Kidney Tubular Necrosis

Drugs for Acute Kidney Tubular Necrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
2 Sodium Potassium Chloride Symporter Inhibitors Phase 4
3 diuretics Phase 4
4
Basiliximab Approved, Investigational Phase 1, Phase 2 179045-86-4
5
Prednisone Approved, Vet_approved Phase 1, Phase 2 53-03-2 5865
6
Mycophenolic acid Approved, Investigational Phase 1, Phase 2 24280-93-1 446541
7
Tacrolimus Approved, Investigational Phase 1, Phase 2 104987-11-3 6473866 445643
8 Anti-Bacterial Agents Phase 1, Phase 2
9 Anti-Infective Agents Phase 1, Phase 2
10 Immunoglobulins Phase 1, Phase 2
11 Calcineurin Inhibitors Phase 1, Phase 2
12 Antilymphocyte Serum Phase 1, Phase 2
13 Antitubercular Agents Phase 1, Phase 2
14 Antibodies Phase 1, Phase 2
15 Antibiotics, Antitubercular Phase 1, Phase 2
16 Immunosuppressive Agents Phase 1, Phase 2
17 Immunologic Factors Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 FURosemide Stress Test to Predict Need of Renal Replacement THERapy in Ischemic Acute Tubular Necrosis in ICU Terminated NCT03731117 Phase 4 Furosemide
2 Effect of Bone Marrow-derived Mesenchymal Stem Cells (BM-MSCs) on Recovery of Poor Early Graft Function Post Kidney Transplantation From Chinese Donation After Citizen Death (DCD): A Multi-center Randomized Controlled Trial Unknown status NCT02563366 Phase 1, Phase 2
3 The Efficacy and Safety of Bone Marrow-derived Mesenchymal Stem Cells in Kidney Transplantation From Chinese Donation After Citizen Death (DCD): A Multi-center Randomized Controlled Trial Unknown status NCT02561767 Phase 1, Phase 2 Induction therapy (ATG or Basiliximab);Maintenance therapy (Low-dose CNI + MPA + steroids)
4 Phase I Clinical Trial, Dose-escalating Intra-aortic Infusion of Allogeneic , Bone Marrow-derived Multipotent Stromal Cells to Prevent and Treat Post-operative Acute Kidney Injury in Patients Who Require On-pump Cardiac Surgery Completed NCT00733876 Phase 1
5 Prospective Multicenter Study to Assess the Predictive Value of PIIINP and Urinary NGAL in Renal Function Recovery During Acute Tubular Necrosis Completed NCT02889575

Search NIH Clinical Center for Acute Kidney Tubular Necrosis

Cochrane evidence based reviews: kidney tubular necrosis, acute

Genetic Tests for Acute Kidney Tubular Necrosis

Anatomical Context for Acute Kidney Tubular Necrosis

Organs/tissues related to Acute Kidney Tubular Necrosis:

MalaCards : Kidney, Bone Marrow, Bone, Liver, Heart, Neutrophil, Endothelial

Publications for Acute Kidney Tubular Necrosis

Articles related to Acute Kidney Tubular Necrosis:

(show top 50) (show all 4204)
# Title Authors PMID Year
1
Atrial natriuretic peptide enhances recovery from ischemia/reperfusion-induced renal injury in rats. 53 62
20471588 2010
2
Atrial natriuretic peptide attenuates ischemia/reperfusion-induced renal injury by reducing neutrophil activation in rats. 53 62
18648186 2008
3
Paraphenylene diamine ingestion: an uncommon cause of acute renal failure. 53 62
17699992 2007
4
Evaluation of hepatocyte growth factor as a sensitive marker for early detection of acute renal allograft rejection. 53 62
17452892 2007
5
Acute renal failure following kidney transplantation associated with myoglobinuria in patients treated with rapamycin. 53 62
16969287 2006
6
[Diagnosis and treatment of 23 cases with rhabdomyolysis related acute renal failure]. 53 62
12857462 2003
7
Role of polymeric Tamm-Horsfall protein in cast formation: oligosaccharide and tubular fluid ions. 53 62
11231348 2001
8
Atrial natriuretic factor in oliguric acute renal failure. Anaritide Acute Renal Failure Study Group. 53 62
11007679 2000
9
Urinary N-acetyl-beta-D-glucosaminidase and neopterin aid in the diagnosis of rejection and acute tubular necrosis in initially nonfunctioning kidney grafts. 53 62
10720893 2000
10
Update on clinical trials with atrial natriuretic peptide in acute tubular necrosis. 53 62
9768436 1998
11
The rise and fall of atrial natriuretic peptide for acute renal failure. 53 62
9327207 1997
12
Diagnostic value of urinary enzyme determination in renal transplantation. 53 62
8959794 1996
13
Effect of 1-28 alpha-h atrial natriuretic peptide on acute renal failure in cadaveric renal transplantation. 53 62
8645892 1995
14
Marked enzymuria after bone marrow transplantation: a correlate of veno-occlusive disease-induced "hepatorenal syndrome". 53 62
8749694 1995
15
[Growth factors in tubular cells]. 53 62
7563623 1995
16
Uromodulin levels are decreased in urine during acute tubular necrosis but not during immune rejection after renal transplantation. 53 62
8382589 1993
17
Acute renal failure in bone marrow transplantation. 53 62
1437667 1992
18
Rhabdomyolysis associated with cocaine abuse. 53 62
1743698 1991
19
Atrial natriuretic factor does not improve the outcome of cadaveric renal transplantation. 53 62
1832982 1991
20
Rhabdomyolysis-induced acute renal failure in a child: a case report. 53 62
2259194 1990
21
AGA Clinical Practice Update on the Evaluation and Management of Acute Kidney Injury in Patients With Cirrhosis: Expert Review. 62
36075500 2022
22
Elevated D-Dimer levels correlate with the development of hepatorenal syndrome and a poor outcome in patients with cirrhosis. 62
35833837 2022
23
Autopsy findings of COVID-19 in children: a systematic review and meta-analysis. 62
36048325 2022
24
Autopsy Case Report of Severe COVID-19 Pneumonia at a General Municipal Hospital. 62
36420546 2022
25
Tertiary lymphoid structure signatures are associated with immune checkpoint inhibitor related acute interstitial nephritis. 62
36472921 2022
26
Natural history, spectrum and outcome of stage 3 AKI in patients with acute-on-chronic liver failure. 62
36017749 2022
27
Diacylglycerol kinase epsilon protects against renal ischemia/reperfusion injury in mice through Krüppel-like factor 15/klotho pathway. 62
35616094 2022
28
Hypothermic Machine Perfusion and Spontaneous Kidney Allograft Rupture: Causation or Correlation? A Case Report and Review of Pertinent Literature. 62
36424228 2022
29
The Pathologic Spectrum of Adenovirus Nephritis in the Kidney Allograft. 62
36436678 2022
30
Causes and outcome of acute kidney injury amongst adults patients in two hospitals of different category in Cameroon; a 5 year retrospective comparative study. 62
36376867 2022
31
AMPK: The key to ischemia-reperfusion injury. 62
36134582 2022
32
Secondary oxalate nephropathy and kidney transplantation. 62
36342385 2022
33
Targeting ACE2 as a potential prophylactic strategy against COVID-19-induced exacerbation of chronic kidney disease. 62
35871404 2022
34
The Ischemia and Reperfusion Injury Involves the Toll-Like Receptor-4 Participation Mainly in the Kidney Cortex. 62
36378153 2022
35
Toxic reaction of a 3-year-old boy due to Hornet multiple stings in Kerman-Iran province: A case report. 62
36403779 2022
36
Severe hypophosphatemia as the initial presentation of renal Fanconi's syndrome and distal renal tubular acidosis related to zoledronic acid: A case report and literature review. 62
36412607 2022
37
Patterns of renal toxicity from the combination of pemetrexed and pembrolizumab for advanced nonsquamous non-small-cell lung cancer (NSCLC): A single-center experience. 62
36356493 2022
38
Acute and chronic histopathological findings in renal biopsies in COVID-19. 62
36396750 2022
39
Zoledronic Acid-Associated Fanconi Syndrome in Patients With Cancer. 62
35219759 2022
40
Clinical and pathological characteristics of patients with acute kidney injury in Japan in whom kidney biopsy was performed: a cross-sectional analysis of the Japan Renal Biopsy Registry (J‑RBR). 62
35595865 2022
41
The Role of Innate Immune Cells in the Prediction of Early Renal Allograft Injury Following Kidney Transplantation. 62
36294469 2022
42
The Impact of Nutritional Supplementation on Donor Kidneys During Oxygenated Ex Vivo Subnormothermic Preservation. 62
36204184 2022
43
Ojeoksan Ameliorates Cisplatin-Induced Acute Kidney Injury in Mice by Downregulating MAPK and NF-κB Pathways. 62
36293111 2022
44
Primary non-function in a deceased donor kidney transplant even with a Kidney Donor Risk Index less than 1.0: a case report. 62
36275986 2022
45
Acute kidney injury in critically ill children: predictive value of renal arterial Doppler assessment. 62
36075988 2022
46
Clarifying expression patterns by renal lesion using transcriptome analysis and vanin-1 as a potential novel biomarker for renal injury in chickens. 62
35901645 2022
47
Pulmonary Histopathology in Cats and Dogs with Fatal Tick Paralysis. 62
36089296 2022
48
Diagnostic and prognostic performance of urinary neutrophil gelatinase-associated lipocalin in patients with cirrhosis and acute kidney injury. 62
36125403 2022
49
Infective Endocarditis-Associated Pauci-Immune Glomerulonephritis in a Patient With Cryoglobulinemia. 62
36059292 2022
50
Protocol-based donor-derived cell-free DNA surveillance in kidney transplant recipients: A single-center experience. 62
35445660 2022

Variations for Acute Kidney Tubular Necrosis

Expression for Acute Kidney Tubular Necrosis

Search GEO for disease gene expression data for Acute Kidney Tubular Necrosis.

Pathways for Acute Kidney Tubular Necrosis

GO Terms for Acute Kidney Tubular Necrosis

Cellular components related to Acute Kidney Tubular Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 10.3 UMOD NAGLU MB LRP2 LCN2 IGFBP7
2 extracellular region GO:0005576 10.05 ACE ACE2 ALB APOL1 CST3 HGF
3 endoplasmic reticulum lumen GO:0005788 9.93 ACE2 ALB APOL1 CST3 IGFBP7 IL6
4 extracellular space GO:0005615 9.74 UMOD REN NPPA LCN2 IL6 IL18

Biological processes related to Acute Kidney Tubular Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.8 UMOD REN LRP2 ACE
2 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.62 ACE2 ACE
3 regulation of blood pressure GO:0008217 9.56 UMOD REN NPPA ACE
4 blood vessel diameter maintenance GO:0097746 9.55 NPPA ACE2 ACE
5 angiotensin maturation GO:0002003 9.1 REN ACE2 ACE

Molecular functions related to Acute Kidney Tubular Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidyl-dipeptidase activity GO:0008241 9.46 ACE2 ACE
2 endopeptidase activity GO:0004175 9.43 REN HGF ACE2 ACE
3 enterobactin binding GO:1903981 8.92 LCN2 ALB

Sources for Acute Kidney Tubular Necrosis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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