Acute Kidney Tubular Necrosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ACT003 MIFTS: 46	Acute Kidney Tubular Necrosis Categories: Nephrological diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

Sources

Aliases & Classifications for Acute Kidney Tubular Necrosis

MalaCards integrated aliases for Acute Kidney Tubular Necrosis:

Name: Acute Kidney Tubular Necrosis ¹² ¹⁵ ¹⁷ ⁷⁰

Acute Tubular Necrosis ¹² ⁷³ ¹⁵

Acute Renal Failure with Tubular Necrosis ¹² ³²

Acute Renal Failure with Lesion of Tubular Necrosis ¹²

Kidney Tubular Necrosis, Acute ⁴⁴

Atn - Acute Tubular Necrosis ¹²

Tubular Necrosis Acute ⁵⁴

Acute Tubule Necrosis ¹²

Classifications:

MalaCards categories:
Anatomical: Nephrological diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the genitourinary system

Renal failure

Acute renal failure

Acute renal failure with tubular necrosis

External Ids:

Disease Ontology ¹² DOID:12556

MeSH ⁴⁴ D007683

NCIt ⁵⁰ C34749

SNOMED-CT ⁶⁷ 23697004

ICD10 ³² N17.0

EFO ¹⁷ EFO_1000794

UMLS ⁷⁰ C0022672

Sources

Summaries for Acute Kidney Tubular Necrosis

Disease Ontology : ¹² An acute kidney failure that is characterized by necrosis of epithelial tubule cells.

MalaCards based summary : Acute Kidney Tubular Necrosis, also known as acute tubular necrosis, is related to ischemia and interstitial nephritis. An important gene associated with Acute Kidney Tubular Necrosis is MB (Myoglobin), and among its related pathways/superpathways are Folate Metabolism and Th1 Differentiation Pathway. The drugs Furosemide and Sodium Potassium Chloride Symporter Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and bone marrow, and related phenotypes are cardiovascular system and cellular

Wikipedia : ⁷³ Acute tubular necrosis (ATN) is a medical condition involving the death of tubular epithelial cells that... more...

Sources

Related Diseases for Acute Kidney Tubular Necrosis

Diseases related to Acute Kidney Tubular Necrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 528)

#	Related Disease	Score	Top Affiliating Genes
1	ischemia	30.7	PIK3C2A MB HGF ACE
2	interstitial nephritis	30.7	UMOD REN HAVCR1 B2M ALB ACE
3	glomerulonephritis	30.6	LRP2 LCN2 B2M ALB ACE
4	renal fibrosis	30.5	TNF REN HGF ALB
5	urinary tract infection	30.4	UMOD LCN2 ACE
6	acute kidney failure	30.4	UMOD REN PIK3C2A NPPA MB LCN2
7	proteinuria, chronic benign	30.4	REN NAGLU LRP2 B2M ALB ACE
8	glomerular disease	30.3	NAGLU ALB ACE
9	iga glomerulonephritis	30.3	REN NAGLU IL6 ALB ACE
10	hepatorenal syndrome	30.2	REN NPPA NAGLU LCN2 IL18 CST3
11	hepatitis a	30.2	TNF HAVCR1 ALB
12	cardiogenic shock	30.2	TNF IL6
13	hypokalemia	30.1	REN ALB ACE
14	peptic esophagitis	30.1	TNF IL6 ALB
15	scrub typhus	30.1	TNF LCN2 IL18 HAVCR1
16	perinatal necrotizing enterocolitis	30.1	TNF IL6 ALB
17	dengue hemorrhagic fever	30.0	TNF IL6 ALB
18	typhoid fever	30.0	TNF IL6 ALB
19	iron deficiency anemia	30.0	TNF MB LCN2 IL6
20	chorioamnionitis	30.0	TNF IL6 IL18
21	anuria	30.0	REN PIK3C2A MB LCN2 HAVCR1 CST3
22	hepatic encephalopathy	30.0	TNF IL6 IL18 ALB
23	focal segmental glomerulosclerosis	29.9	TNF LCN2 IL6 ALB ACE
24	cardiac arrest	29.9	REN PIK3C2A LCN2 ALB ACE
25	gastroenteritis	29.9	TNF REN IL6 ALB
26	endocarditis	29.9	TNF PIK3C2A IL6 ALB
27	acute pyelonephritis	29.9	NAGLU LCN2 IL6 ALB ACE
28	exanthem	29.9	TNF PIK3C2A IL6 IL18 ALB ACE
29	sickle cell anemia	29.9	TNF IL6 ALB ACE
30	cystitis	29.8	UMOD TNF IL6 IL18 CST3
31	alcoholic hepatitis	29.8	TNF IL6 IL18 HGF ALB
32	liver cirrhosis	29.8	TNF REN NPPA IL6 HGF CST3
33	end stage renal disease	29.7	UMOD TNF REN IL6 HAVCR1 CST3
34	peritonitis	29.7	TNF IL6 IL18 B2M ALB
35	pericardial effusion	29.7	REN PIK3C2A NPPA IL6 ALB ACE
36	fanconi syndrome	29.7	UMOD OGA NAGLU LRP2 B2M ALB
37	pyelonephritis	29.6	UMOD TNF NAGLU LCN2 IL6 ALB
38	myeloma, multiple	29.6	TNF MIR142 IL6 B2M ALB
39	compartment syndrome	29.6	TNF PIK3C2A MB LCN2 IL6 ALB
40	pheochromocytoma	29.6	TNF REN NPPA IL6 ACE
41	respiratory failure	29.6	TNF REN PIK3C2A NPPA IL6 ALB
42	urinary tract obstruction	29.5	UMOD REN NAGLU MIR142 LCN2 HAVCR1
43	osteoporosis	29.3	TNF IL6 IL18 CST3 B2M ALB
44	nephrotic syndrome	29.2	TNF REN NPPA NAGLU LRP2 IL6
45	malaria	29.2	TNF MB LCN2 IL6 IL18 B2M
46	deficiency anemia	29.1	TNF NPPA MB LCN2 IL6 CST3
47	kidney disease	29.0	UMOD TNF REN NPPA NAGLU LRP2
48	chronic kidney disease	28.7	UMOD TNF REN NPPA LCN2 IL6
49	hemoglobinuria	11.2
50	encephalopathy, progressive, early-onset, with episodic rhabdomyolysis	10.5

Graphical network of the top 20 diseases related to Acute Kidney Tubular Necrosis:

Sources

Symptoms & Phenotypes for Acute Kidney Tubular Necrosis

MGI Mouse Phenotypes related to Acute Kidney Tubular Necrosis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	10.38	ACE ALB B2M CST3 HGF IL18
2	cellular	MP:0005384	10.3	ALB B2M CST3 HGF IL18 IL6
3	growth/size/body region	MP:0005378	10.28	ACE B2M HGF IL18 IL6 LCN2
4	hematopoietic system	MP:0005397	10.25	ACE B2M FABP1 HGF IL18 IL6
5	homeostasis/metabolism	MP:0005376	10.24	ACE ALB B2M CST3 FABP1 IL18
6	immune system	MP:0005387	10.13	ACE ALB B2M FABP1 IL18 IL6
7	mortality/aging	MP:0010768	10.03	ACE ALB B2M CST3 HGF IL18
8	liver/biliary system	MP:0005370	9.91	ACE ALB B2M FABP1 HGF IL6
9	muscle	MP:0005369	9.56	ALB CST3 IL18 IL6 MB NPPA
10	renal/urinary system	MP:0005367	9.32	ACE ALB IL6 LCN2 LRP2 NAGLU

Sources

Drugs & Therapeutics for Acute Kidney Tubular Necrosis

Drugs for Acute Kidney Tubular Necrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Furosemide

Approved, Vet_approved

Phase 4

54-31-9

3440

Synonyms:

2-Furfurylamino-4-chloro-5-sulfamoylbenzoate

2-Furfurylamino-4-chloro-5-sulfamoylbenzoic acid

2-Furfurylamino-4-chloro-5-sulphamoylbenzoate

2-Furfurylamino-4-chloro-5-sulphamoylbenzoic acid

41733-55-5 (mono-hydrochloride salt)

4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid

4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbenzoic acid

4-Chloro-5-sulfamoyl-N-furfuryl-anthranilate

4-Chloro-5-sulfamoyl-N-furfuryl-anthranilic acid

4-Chloro-5-sulphamoyl-N-furfuryl-anthranilate

4-Chloro-5-sulphamoyl-N-furfuryl-anthranilic acid

4-Chloro-N-(2-furylmethyl)-5-sulfamoylanthranilate

4-Chloro-N-(2-furylmethyl)-5-sulfamoylanthranilic acid

4-Chloro-N-(2-furylmethyl)-5-sulphamoylanthranilate

4-Chloro-N-(2-furylmethyl)-5-sulphamoylanthranilic acid

4-Chloro-N-furfuryl-5-sulfamoylanthranilate

4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid

4-Chloro-N-furfuryl-5-sulphamoylanthranilate

4-Chloro-N-furfuryl-5-sulphamoylanthranilic acid

5-18-09-00555 (Beilstein Handbook Reference)

54-31-9

AB00052001

AC-11067

AC1L1FXW

AC1Q557O

Acetic acid potassium salt

Aisemide

AKOS000266625

Aldalix

Aldic

Aluzine

Anfuramaide

Apo-frusemide

Apo-Frusemide

Apo-furosemide

Apo-Furosemide

Aquarid

Aquasin

Arasemide

ARONIS24304

Beronald

BIDD:GT0139

Bio-0044

Bioretic

BPBio1_000443

BRD-K78010432-001-05-8

Bristab

Bristurin

BRN 0840915

BSPBio_000401

BSPBio_002054

C12H11ClN2O5S

CAS-54-31-9

CCRIS 1951

Cetasix

CHEBI:47426

CHEMBL35

Chlor-N-(2-furylmethyl)-5-sulfamylanthranilsaeure

Chlor-N-(2-furylmethyl)-5-sulfamylanthranilsaeure [German]

CID3440

CPD000058202

D00331

D005665

DB00695

DB07799

Depix

Desal

Desdemin

Di-Ademil

Dihydroflumethiazide

Dirine

Disal

Discoid

Disemide

Diucardin

Diumide-K

Diural

Diurapid

Diuretic salt

Diuretic Salt

Diurin

Diurolasa

Diusemide

Diusil

Diuzol

DivK1c_000575

Dranex

Dryptal

Durafurid

Edemid

Edenol

EINECS 200-203-6

Eliur

Elodrine

Endural

Errolon

Eutensin

F0182

F4381_SIGMA

Farsix

Finuret

Fluidrol

Fluss

Franyl

Frumex

Frumide

Frumil

Frusedan

Frusema

Frusemid

Frusemide

Frusemin

Frusenex

Frusetic

Frusid

Fu sid

Fulsix

Fuluvamide

Fuluvamine

fulvamide

FUN

Furanthril

Furanthryl

Furantral

Furantril

Furanturil

Furesis

Furetic

Furex

Furfan

Furix

Furmid

Furo-basan

Furo-Basan

Furobeta

Furocot

Furodiurol

Furodrix

Furomen

Furomex

Furomide M.D

Furomide m.d.

Furomide M.D.

Furo-puren

Furo-Puren

Furorese

Furosan

Furose

Furosedon

Furosemid

Furosemida

Furosemida [INN-Spanish]

furosemide

Furosemide

Furosemide "mita"

Furosemide (JP15/USP/INN)

Furosemide [USAN:INN:JAN]

furosemide ''mita''

Furosemide monohydrochloride

Furosemide Monohydrochloride

Furosemide monosodium salt

Furosemide Monosodium Salt

FUROSEMIDE USP

Furosemidu

Furosemidu [Polish]

Furosemidum

Furosemidum [INN-Latin]

Furosemix

Furoside

Furosifar

Furosix

Furoter

Furovite

Fursemid

Fursemida

Fursemide

Fursol

Fusid

Fusidic acid

Golan

Hissuflux

HMS1569E03

HMS1920B03

HMS2090K06

HMS2091H05

HMS501M17

Hoe-058A

HSDB 3086

Hydol

Hydrenox

Hydrex

Hydro

Hydroled

Hydro-rapid

Hydro-Rapid

I04-0179

IDI1_000575

Impugan

Jenafusid

Katlex

KBio1_000575

KBio2_001580

KBio2_004148

KBio2_006716

KBio3_001274

KBioGR_001259

KBioSS_001580

Kofuzon

Kolkin

Kutrix

Lasemid

Lasex

Lasiletten

Lasilix

Lasix

Lasix (TN)

Lasix retard

Lasix Retard

Lasix Special

Lasix, Frusemide, Furosemide

Laxur

Lazix

LB 502

LB-502

Leodrine

less Diur

Less diur

Less Diur

Liside

Logirene

Lowpston

Lowpstron

LS-204

Luscek

Macasirool

Marsemide

Metflorylthiazidine

Methforylthiazidine

Mirfat

Mita

MLS001066374

MLS001306403

Moilarorin

MolPort-001-641-065

Myrosemide

Nadis

NCGC00016241-01

NCGC00090893-01

NCGC00090893-02

NCGC00090893-03

NCGC00090893-05

NCGC00090893-06

NCI-C55936

Nelsix

Neo-renal

Neo-Renal

Nephron

Nicorol

NINDS_000575

Novosemide

NSC 269420

NSC269420

Octan draselny

Octan Draselny

Odemase

Odemex

Oedemex

Olmagran

Oprea1_667724

Osyrol

Polysquall a

Polysquall A

Prefemin

Prestwick_752

Prestwick0_000341

Prestwick1_000341

Prestwick2_000341

Prestwick3_000341

Profemin

Promedes

Promide

Protargen

Puresis

Radisemide

Radonna

Radouna

Retep

Rodiuran

Rontyl

Rosemide

Rosis

Rusyde

S1603_Selleck

Sal diureticum

Sal Diureticum

Salinex

Salix

Salix (brand of furosemide)

Salix (brand OF furosemide)

Salurex

Salurid

Saluron

SAM002264614

Seguril

Selectofur

Sigasalur

Sisuril

SMP1_000129

SMR000058202

SPBio_001129

SPBio_002322

Spectrum_001100

SPECTRUM1500310

Spectrum2_001005

Spectrum3_000437

Spectrum4_000560

Spectrum5_000744

Spirofur

STK177334

Synephron

TL8003563

Transit

Trofurit

UNII-7LXU5N7ZO5

UPCMLD-DP022

UPCMLD-DP022:001

Uremide

Uresix

Urex

Urex-m

Urex-M

Urian

Uridon

Uritol

Urosemide

Vergonil

Vesix

WLN: T5OJ B1MR CG FVQ DSZW

Yidoli

Zafimida

Sodium Potassium Chloride Symporter Inhibitors

Phase 4

diuretics

Phase 4

Prednisone

Approved, Vet_approved

Phase 1, Phase 2

53-03-2

5865

Synonyms:

(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-5,17-dione

(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione

(8xi,9xi,14xi)-17,21-dihydroxypregna-1,4-diene-3,11,20-trione

.delta. E

.delta.(sup1)-Cortisone

.delta.1-Cortisone

.delta.1-Dehydrocortisone

.delta.-Cortelan

.delta.-Cortisone

.delta.-Cortone

.delta.-E

.delta.sone

1,2-Dehydrocortisone

1,4-Pregnadiene-17.alpha.,21-diol-3,11,20-trione

1,4-Pregnadiene-17a,21-diol-3,11,20-trione

1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione

1,4-Pregnadiene-17-alpha,21-diol-3,11,20-trione

1,4-Pregnadiene-17α,21-diol-3,11,20-trione

17,21-Dihydroxypregna-1,4-diene-3,11,20-trione

17alpha,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione

1-Cortisone

1-Dehydrocortisone

53-03-2

68-59-7

81552_FLUKA

AC-11112

AC1L1LB2

AC1Q29EZ

Acis brand OF prednisone

ACon0_000082

ACon1_000297

Acsis, prednison

Adasone

AI3-52939

Ancortone

Apo-prednisone

Apo-Prednisone

Apotex brand OF prednisone

Aventis brand OF prednisone

Betapar

Bicortone

Bio-0649

BPBio1_000323

BRD-K85883481-001-04-2

BSPBio_000293

C07370

C21H26O5

Cartancyl

CCRIS 2646

CHEBI:8382

CHEMBL635

CID5865

Colisone

Cortan

Cortancyl

Cortidelt

Cotone

CPD001227202

Cutason

Dacorten

Dacortin

DB00635

Decortancyl

Decortin

Decortisyl

Dehydrocortisone

Dekortin

Delcortin

Dellacort

Dellacort A

delta cortelan

Delta Cortelan

Delta E

Delta E.

delta(sup 1)-Cortisone

delta(sup 1)-Dehydrocortisone

delta-1-Cortisone

delta-1-Dehydrocortisone

Delta-cortelan

Delta-Cortelan

Deltacortene

delta-Cortisone

Deltacortisone

Delta-cortisone

delta-Cortone

Deltacortone

Delta-cortone

Delta-dome

Delta-Dome

Deltasone

Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone,Prednisone

Deltison

Deltisona

Deltisone

Deltra

Diadreson

Di-Adreson

Diba brand OF prednisone

Econosone

EINECS 200-160-3

Encorton

Encortone

Enkortolon

Enkorton

Fawns and mcallan brand OF prednisone

Fernisone

Ferring brand OF prednisone

Fiasone

GALENpharma brand OF prednisone

Halsey drug brand OF prednisone

Hexal brand OF prednisone

HMS1568O15

HMS2090J13

Hoechst brand OF prednisone

Hostacortin

HSDB 3168

ICN brand OF prednisone

Incocortyl

In-Sone

Juvason

Kortancyl

Lichtenstein brand OF prednisone

Liquid pred

Liquid Pred

Lisacort

LMST02030180

Lodotra

LS-1325

MEGxm0_000443

Me-Korti

Merck brand OF prednisone

Merz brand OF prednisone

Metacortandracin

Meticorten

Meticorten (Veterinary)

Metrevet (Veterinary)

Mibe brand OF prednisone

MLS001061265

MLS001304073

MLS001335907

MLS001335908

MLS002154191

MLS002207083

MolPort-001-740-041

NCGC00090766-01

NCGC00090766-02

NCGC00090766-03

NCI60_000008

NCI-C04897

Nisona

Nizon

Novoprednisone

NSC 10023

NSC10023

Nurison

Orasone

Origen Prednisone

P1276

P6254_SIGMA

Panafcort

Panasol

Paracort

Parmenison

Pehacort

Pharmacia brand OF prednisone

PRD

Precort

Predeltin

Predni tablinen

Prednicen-M

Prednicorm

Prednicort

Prednicot

Prednidib

Prednilonga

Predniment

Prednison

Prednison acsis

Prednison galen

Prednison hexal

Prednisona

Prednisona [INN-Spanish]

Prednisone

Prednisone [INN:BAN]

Prednisone Intensol

Prednisonum

Prednisonum [INN-Latin]

Prednitone

Prednizon

Prednovister

Presone

Prestwick_405

Prestwick0_000077

Prestwick1_000077

Prestwick2_000077

Prestwick3_000077

Pronison

Pronisone

Rectodelt

Retrocortine

S1622_Selleck

SAM002264641

Schering-plough brand OF prednisone

Seatrace brand OF prednisone

Servisone

SK-Prednisone

SMR000718760

SMR001227202

Solvay brand OF prednisone

Sone

SPBio_002214

Sterapred

Supercortil

Trommsdorff brand OF prednisone

U 6020

Ultracorten

Ultracortene

UNII-VB0R961HZT

Winpred

WLN: L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ

Wojtab

Zenadrid

Zenadrid (veterinary)

Zenadrid [veterinary]

ZINC03875357

Tacrolimus

Approved, Investigational

Phase 1, Phase 2

104987-11-3

6473866 445643 439492

Synonyms:

(-)-FK 506

(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone

104987-11-3

109581-93-3 (Hydrate)

15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone,

3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5, 19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c] [1,4] oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone

8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN

AC-1182

AC1L1K7H

AC1L97GB

AC1L9IBU

Advagraf

AKOS005145901

Ambap104987-11-3

Ambap5429

Anhydrous tacrolimus

Anhydrous, tacrolimus

BCBcMAP01_000194

Bio-0921

Bio2_000470

Bio2_000950

BRD-K35452788-001-02-1

BSPBio_001279

BSPBio-001279

C01375

C44H69NO10

CCRIS 7124

CHEBI:100924

CHEBI:61049

CHEMBL1200738

CID11158639

CID11556866

CID439492

CID445643

CID5372

CID5472317

CID6426916

CID6436007

CID6473866

CID6536850

CID6610362

CID6912836

CID9832283

CID9853905

CID9918805

CID9940643

CID9963169

Cilag brand OF tacrolimus

CPD000466356

CPD-10016

D08556

DB00864

DivK1c_001040

FK 506

FK5

Fk-506

FK506

FK-506

FR 900506

FR900506

FR-900506

FT-0082660

Fujimycin

Fujisawa brand OF tacrolimus

Graceptor

HMS1362O21

HMS1792O21

HMS1990O21

HMS2051C18

HMS2093M19

HMS503O21

IDI1_001040

IDI1_002225

Janssen brand OF tacrolimus

K506

KBio1_001040

KBio2_000619

KBio2_003187

KBio2_005755

KBio3_001097

KBio3_001098

KBioGR_000619

KBioSS_000619

L 679934

L-679934

LCP-Tacro

LMPK04000003

LS-64247

MLS000759471

MLS001424054

Modigraf

MolPort-003-666-518

NCGC00163470-01

NCGC00163470-02

NCGC00163470-03

NCGC00163470-04

NCGC00179232-01

NChemBio.2007.16-comp1

nchembio.2007.23-comp2

NINDS_001040

NSC717865

Prograf

Prograf (TN)

Prograft

Protopic

Protopy

S5003_Selleck

SAM001246677

SMR000466356

Tacarolimus

tacrolimus

Tacrolimus

Tacrolimus (anhydrous)

Tacrolimus (INN)

Tacrolimus (Prograf?)

Tacrolimus anhydrous

tacrolimus hydrate

Tacrolimus, anhydrous

Tsukubaenolide

UNII-Y5L2157C4J

Basiliximab

Approved, Investigational

Phase 1, Phase 2

152923-56-3, 179045-86-4

Mycophenolic acid

Approved

Phase 1, Phase 2

24280-93-1

446541

Synonyms:

(e)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate

(e)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid

Acid, mycophenolic

Acide mycophenolique

Acido micofenolico

Acidum mycophenolicum

Cellcept

Melbex

Micofenolico acido

Mofetil hydrochloride, mycophenolate

Mofetil, mycophenolate

Mycophenoic acid

Mycophenolate

Mycophenolate mofetil

Mycophenolate mofetil hydrochloride

Mycophenolate sodium

Mycophenolate, sodium

Mycophenolic acid

Mycophenolic acid morpholinoethyl ester

Mycophenolsaeure

Mycophenolsäure

Myfortic

Sodium mycophenolate

Antibiotics, Antitubercular

Phase 1, Phase 2

Immunosuppressive Agents

Phase 1, Phase 2

Antibodies

Phase 1, Phase 2

Immunologic Factors

Phase 1, Phase 2

Immunoglobulins

Phase 1, Phase 2

Anti-Bacterial Agents

Phase 1, Phase 2

Antitubercular Agents

Phase 1, Phase 2

Calcineurin Inhibitors

Phase 1, Phase 2

Antilymphocyte Serum

Phase 1, Phase 2

Anti-Infective Agents

Phase 1, Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	FURosemide Stress Test to Predict Need of Renal Replacement THERapy in Ischemic Acute Tubular Necrosis in ICU	Terminated	NCT03731117	Phase 4	Furosemide
2	Effect of Bone Marrow-derived Mesenchymal Stem Cells (BM-MSCs) on Recovery of Poor Early Graft Function Post Kidney Transplantation From Chinese Donation After Citizen Death (DCD): A Multi-center Randomized Controlled Trial	Unknown status	NCT02563366	Phase 1, Phase 2
3	The Efficacy and Safety of Bone Marrow-derived Mesenchymal Stem Cells in Kidney Transplantation From Chinese Donation After Citizen Death (DCD): A Multi-center Randomized Controlled Trial	Unknown status	NCT02561767	Phase 1, Phase 2	Induction therapy (ATG or Basiliximab);Maintenance therapy (Low-dose CNI + MPA + steroids)
4	Phase I Clinical Trial, Dose-escalating Intra-aortic Infusion of Allogeneic , Bone Marrow-derived Multipotent Stromal Cells to Prevent and Treat Post-operative Acute Kidney Injury in Patients Who Require On-pump Cardiac Surgery	Completed	NCT00733876	Phase 1
5	Prospective Multicenter Study to Assess the Predictive Value of PIIINP and Urinary NGAL in Renal Function Recovery During Acute Tubular Necrosis	Completed	NCT02889575

Search NIH Clinical Center for Acute Kidney Tubular Necrosis

Cochrane evidence based reviews: kidney tubular necrosis, acute

Sources

Genetic Tests for Acute Kidney Tubular Necrosis

Sources

Anatomical Context for Acute Kidney Tubular Necrosis

MalaCards organs/tissues related to Acute Kidney Tubular Necrosis:

⁴⁰

Kidney, Liver, Bone Marrow, Bone, Heart, Endothelial, Neutrophil

Sources

Publications for Acute Kidney Tubular Necrosis

Articles related to Acute Kidney Tubular Necrosis:

(show top 50) (show all 3373)

#	Title	Authors	PMID	Year
1	Atrial natriuretic peptide enhances recovery from ischemia/reperfusion-induced renal injury in rats. ⁶¹ ⁵⁴	Chujo K...Ueki M	20471588	2010
2	Atrial natriuretic peptide attenuates ischemia/reperfusion-induced renal injury by reducing neutrophil activation in rats. ⁶¹ ⁵⁴	Chujo K...Taie S	18648186	2008
3	Paraphenylene diamine ingestion: an uncommon cause of acute renal failure. ⁵⁴ ⁶¹	Ram R...Dakshinamurty KV	17699992	2007
4	Evaluation of hepatocyte growth factor as a sensitive marker for early detection of acute renal allograft rejection. ⁶¹ ⁵⁴	Mahmoud K...Susal C	17452892	2007
5	Acute renal failure following kidney transplantation associated with myoglobinuria in patients treated with rapamycin. ⁶¹ ⁵⁴	Pelletier R...Ferguson R	16969287	2006
6	[Diagnosis and treatment of 23 cases with rhabdomyolysis related acute renal failure]. ⁵⁴ ⁶¹	Zhang W...Wang GY	12857462	2003
7	Role of polymeric Tamm-Horsfall protein in cast formation: oligosaccharide and tubular fluid ions. ⁶¹ ⁵⁴	Wangsiripaisan A...Schrier RW	11231348	2001
8	Atrial natriuretic factor in oliguric acute renal failure. Anaritide Acute Renal Failure Study Group. ⁶¹ ⁵⁴	Lewis J...Allgren RL	11007679	2000
9	Urinary N-acetyl-beta-D-glucosaminidase and neopterin aid in the diagnosis of rejection and acute tubular necrosis in initially nonfunctioning kidney grafts. ⁶¹ ⁵⁴	Kotanko P...Pfaller W	10720893	2000
10	Update on clinical trials with atrial natriuretic peptide in acute tubular necrosis. ⁶¹ ⁵⁴	Allgren RL	9768436	1998
11	The rise and fall of atrial natriuretic peptide for acute renal failure. ⁵⁴ ⁶¹	Brenner RM...Chertow GM	9327207	1997
12	Diagnostic value of urinary enzyme determination in renal transplantation. ⁵⁴ ⁶¹	Sarvary E...Perner F	8959794	1996
13	Effect of 1-28 alpha-h atrial natriuretic peptide on acute renal failure in cadaveric renal transplantation. ⁵⁴ ⁶¹	Gianello P...Squifflet JP	8645892	1995
14	Marked enzymuria after bone marrow transplantation: a correlate of veno-occlusive disease-induced "hepatorenal syndrome". ⁶¹ ⁵⁴	Fink JC...Zager RA	8749694	1995
15	[Growth factors in tubular cells]. ⁶¹ ⁵⁴	Okuda S	7563623	1995
16	Uromodulin levels are decreased in urine during acute tubular necrosis but not during immune rejection after renal transplantation. ⁶¹ ⁵⁴	McLaughlin PJ...Johnson PM	8382589	1993
17	Acute renal failure in bone marrow transplantation. ⁶¹ ⁵⁴	King CR...Murray ME	1437667	1992
18	Rhabdomyolysis associated with cocaine abuse. ⁶¹ ⁵⁴	Nolte KB	1743698	1991
19	Atrial natriuretic factor does not improve the outcome of cadaveric renal transplantation. ⁵⁴ ⁶¹	Sands JM...Mitch WE	1832982	1991
20	Rhabdomyolysis-induced acute renal failure in a child: a case report. ⁶¹ ⁵⁴	Murugasu B...Chiang GS	2259194	1990
21	15-Hydroxyprostaglandin dehydrogenase inhibitor prevents contrast-induced acute kidney injury. ⁶¹	Kim BW...Bae KB	33459127	2021
22	Grafts With Multiple Renal Arteries in Kidney Transplantation. ⁶¹	Sevmis M...Uyar M	32950261	2021
23	[Therapeutics for acute tubular necrosis in 2020]. ⁶¹	Lafargue MC...Essig M	33483244	2021
24	Thrombotic microangiopathy led to acute kidney injury in an infant with hemophagocytic lymphohistiocytosis: A case report. ⁶¹	Guo HY...Fang D	33680118	2021
25	A rare case of acute tubular necrosis tenofovir alafenamide-related. ⁶¹	Pontolillo M...Vecchiet J	33749582	2021
26	Cocaine nephropathy: A rare cause of abnormal nephrograms. ⁶¹	Lamberg H...Millet JD	33510825	2021
27	Emergence and molecular characterization of pigeon Paramyxovirus-1 in non-native Eurasian collared doves (Streptopelia decaocto) in California, USA. ⁶¹	Rogers KH...Crossley B	33727141	2021
28	Atypical hemolytic uremic syndrome and acute tubular necrosis induced by complement factor B gene (CFB) mutation: A case report. ⁶¹	Wu H...Zhang L	33725982	2021
29	Kidney biopsy findings in vancomycin-induced acute kidney injury: a pooled analysis. ⁶¹	Bellos I...Perrea DN	33715061	2021
30	Renal involvement in Mediterranean spotted fever - clinical and histopathological data. ⁶¹	Baltadzhiev I...Baltadjiev A	33780958	2021
31	Gene deficiency or pharmacological inhibition of PDCD4-mediated FGR signaling protects against acute kidney injury. ⁶¹	Jing X...Zhang Y	33643819	2021
32	Embolic Characteristics of Imipenem-Cilastatin Particles in Vitro and in Vivo: Implications for Transarterial Embolization in Joint Arthropathies. ⁶¹	Yamada K...Horikawa M	33607251	2021
33	Outcomes of Delayed Graft Function in Kidney Transplant Recipients Stratified by Histologic Biopsy Findings. ⁶¹	Rolak S...Parajuli S	33579551	2021
34	MicroRNAs: small molecules, big effects. ⁶¹	Tinel C...Anglicheau D	33278152	2021
35	Post-mortem Histopathologic Findings of Vital Organs in Critically Ill Patients with COVID-19. ⁶¹	Bidari Zerehpoosh F...Alavi Darazam I	33636984	2021
36	Recovery of kidney function after dialysis initiation in children and adults in the US: A retrospective study of United States Renal Data System data. ⁶¹	Ku E...Liu KD	33606673	2021
37	Acute kidney injury and renal tubular damage in children with type 1 diabetes mellitus onset. ⁶¹	Marzuillo P...Miraglia Del Giudice E	33595665	2021
38	Renal failure and hepatitis following ingestion of raw grass carp gallbladder: A case report. ⁶¹	Zhou LN...Huang W	33585643	2021
39	Concomitant nephrotic syndrome and tubulointerstitial nephritis in a child with Epstein-Barr virus mononucleosis. ⁶¹	Acharya R...Upadhyay K	33541950	2021
40	Role of Damage-Associated Molecular Patterns in Septic Acute Kidney Injury, From Injury to Recovery. ⁶¹	Ludes PO...Mebazaa A	33732235	2021
41	Acute kidney injury induced by glycerol is worsened by orchiectomy and attenuated by testosterone replacement. ⁶¹	de Souza SI...de Jesus Soares T	33171132	2021
42	Silence of Long Noncoding RNA SNHG14 Alleviates Ischemia/Reperfusion-Induced Acute Kidney Injury by Regulating miR-124-3p/MMP2 Axis. ⁶¹	Xue Q...Han S	33490282	2021
43	Imaging in Renal Transplants: An Update. ⁶¹	Volkan-Salanci B...Erbas B	33485623	2021
44	[Acute renal failure of the donor in encephalic death: A real contraindication to kidney transplantation?] ⁶¹	Fosse A...Branchereau J	33478867	2021
45	Comparison of Centrifugal and Pulsatile Perfusion to Preserve Donor Kidneys Using Ex Vivo Subnormothermic Perfusion. ⁶¹	Luke PPW...Bhattacharjee RN	33400888	2021
46	Success Rate of Grafts With Multiple Renal Vessels in 3136 Kidney Transplants. ⁶¹	Karakaya E...Haberal M	32967599	2021
47	Retrospective Analysis of the Comparison Between Single Renal Artery Versus Multiple Renal Arteries in Living Donor Kidney Transplant: Does It Affect the Outcome? ⁶¹	Mahajan AD...Patil M	33272157	2021
48	Hepatorenal Syndrome: Pathophysiology and evidence-based management update. ⁶¹	Hasan I...Wadei HM	33544554	2021
49	Unusual case of polyarthritis and hepatorenal syndrome associated with Leptospira interrogans infection in a dog: A case report. ⁶¹	Paz LN...Pinna MH	33388616	2021
50	[Acute kidney failure in patients admitted due to COVID-19]. ⁶¹	Tarragon B...Portoles J	33162225	2021

Sources

Genes for Acute Kidney Tubular Necrosis

Genes related to Acute Kidney Tubular Necrosis (0 elite genes):

(show all 25)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	MB	Myoglobin	Protein Coding	12.56	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	2259194 1437667 17699992 (more) 12857462 1743698 16969287
2	UMOD	Uromodulin	Protein Coding	10.01	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	8382589 11231348
3	NPPA	Natriuretic Peptide A	Protein Coding	9.8	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	11007679 9768436 8645892 (more) 9327207 1832982
4	HGF	Hepatocyte Growth Factor	Protein Coding	9.01	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	7563623 17452892
5	HAVCR1	Hepatitis A Virus Cellular Receptor 1	Protein Coding	8.35	DISEASES inferred ¹⁵
6	LCN2	Lipocalin 2	Protein Coding	8.07	DISEASES inferred ¹⁵
7	ALB	Albumin	Protein Coding	7.21	DISEASES inferred ¹⁵
8	CST3	Cystatin C	Protein Coding	7.14	DISEASES inferred ¹⁵
9	MIR142	MicroRNA 142	RNA Gene	7.04	DISEASES inferred ¹⁵ ¹⁵
10	IL18	Interleukin 18	Protein Coding	6.86	DISEASES inferred ¹⁵
11	FABP1	Fatty Acid Binding Protein 1	Protein Coding	6.82	DISEASES inferred ¹⁵
12	OGA	O-GlcNAcase	Protein Coding	6.71	DISEASES inferred ¹⁵
13	REN	Renin	Protein Coding	6.58	DISEASES inferred ¹⁵
14	NAGLU	N-Acetyl-Alpha-Glucosaminidase	Protein Coding	6.58	Novoseek inferred ⁵⁴	20471588 10720893 8749694 (more) 18648186
15	ACE	Angiotensin I Converting Enzyme	Protein Coding	6.43	DISEASES inferred ¹⁵
16	PIK3C2A	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha	Protein Coding	6.33	DISEASES inferred ¹⁵
17	B2M	Beta-2-Microglobulin	Protein Coding	6.26	DISEASES inferred ¹⁵
18	IL6	Interleukin 6	Protein Coding	6.24	DISEASES inferred ¹⁵
19	LRP2	LDL Receptor Related Protein 2	Protein Coding	6.24	DISEASES inferred ¹⁵
20	TNF	Tumor Necrosis Factor	Protein Coding	6.11	DISEASES inferred ¹⁵
21	HMOX1	Heme Oxygenase 1	Protein Coding	6.1	DISEASES inferred ¹⁵
22	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	5.96	DISEASES inferred ¹⁵
23	F2	Coagulation Factor II, Thrombin	Protein Coding	5.9	DISEASES inferred ¹⁵
24	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	5.82	DISEASES inferred ¹⁵
25	CD4	CD4 Molecule	Protein Coding	5.8	DISEASES inferred ¹⁵

Sources

Variations for Acute Kidney Tubular Necrosis

Sources

Expression for Acute Kidney Tubular Necrosis

Search GEO for disease gene expression data for Acute Kidney Tubular Necrosis.

Sources

Pathways for Acute Kidney Tubular Necrosis

Pathways related to Acute Kidney Tubular Necrosis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Folate Metabolism ¹ Show member pathways Selenium Micronutrient Network ¹ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.07	TNF LRP2 IL6 ALB
2	Th1 Differentiation Pathway ⁶⁴ Show member pathways IL27-mediated signaling events ¹	11.53	TNF IL6 IL18
3	Renin secretion ³⁶	11.47	REN NPPA ACE
4	Interleukin-4 and 13 signaling ⁶⁵	11.41	TNF LCN2 IL6 IL18 HGF
5	Lung fibrosis ¹	11.38	TNF IL6 HGF
6	Legionellosis ³⁶	11.3	TNF IL6 IL18
7	Interleukin-10 signaling ⁶⁵	11.19	TNF IL6 IL18
8	Malaria ³⁶	11.16	TNF IL6 IL18 HGF
9	Development and heterogeneity of the ILC family ¹	10.94	TNF IL6 IL18
10	African trypanosomiasis ³⁶	10.49	TNF NPPA IL6 IL18

Sources

GO Terms for Acute Kidney Tubular Necrosis

Cellular components related to Acute Kidney Tubular Necrosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular exosome	GO:0070062	9.9	UMOD PIK3C2A NAGLU MB LRP2 LCN2
2	extracellular region	GO:0005576	9.73	UMOD TNF REN NPPA LCN2 IL6
3	extracellular space	GO:0005615	9.44	UMOD TNF REN NPPA MIR142 LCN2

Biological processes related to Acute Kidney Tubular Necrosis according to GeneCards Suite gene sharing:

(show all 17)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.72	TNF IL6 IL18
2	cellular response to hydrogen peroxide	GO:0070301	9.69	LCN2 IL6 FABP1
3	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO:0043154	9.67	TNF HGF FABP1
4	positive regulation of protein kinase B signaling	GO:0051897	9.67	TNF LRP2 IL18 HGF
5	regulation of blood pressure	GO:0008217	9.65	REN NPPA ACE
6	cytokine-mediated signaling pathway	GO:0019221	9.65	TNF LCN2 IL6 IL18 HGF
7	kidney development	GO:0001822	9.62	UMOD REN LRP2 ACE
8	positive regulation of smooth muscle cell proliferation	GO:0048661	9.61	TNF IL6 IL18
9	angiotensin maturation	GO:0002003	9.57	REN ACE
10	neutrophil mediated immunity	GO:0002446	9.56	IL6 ACE
11	cellular response to nicotine	GO:0071316	9.54	TNF B2M
12	negative regulation of lipid storage	GO:0010888	9.52	TNF IL6
13	negative regulation of bicellular tight junction assembly	GO:1903347	9.46	TNF MIR142
14	vascular endothelial growth factor production	GO:0010573	9.4	TNF IL6
15	cellular protein metabolic process	GO:0044267	9.35	NPPA IL6 CST3 B2M ALB
16	negative regulation of neurogenesis	GO:0050768	9.33	TNF IL6 B2M
17	positive regulation of neuroinflammatory response	GO:0150078	8.92	TNF MIR142 IL6 IL18

Molecular functions related to Acute Kidney Tubular Necrosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	enterobactin binding	GO:1903981	8.62	LCN2 ALB

Sources

Sources for Acute Kidney Tubular Necrosis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Apr-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia