MCID: ACT003
MIFTS: 45

Acute Kidney Tubular Necrosis

Categories: Nephrological diseases

Aliases & Classifications for Acute Kidney Tubular Necrosis

MalaCards integrated aliases for Acute Kidney Tubular Necrosis:

Name: Acute Kidney Tubular Necrosis 12 15 17 71
Acute Tubular Necrosis 12 74 15
Acute Renal Failure with Tubular Necrosis 12 32
Acute Renal Failure with Lesion of Tubular Necrosis 12
Kidney Tubular Necrosis, Acute 43
Atn - Acute Tubular Necrosis 12
Tubular Necrosis Acute 54
Acute Tubule Necrosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12556
MeSH 43 D007683
NCIt 49 C34749
SNOMED-CT 67 35455006
ICD10 32 N17.0
UMLS 71 C0022672

Summaries for Acute Kidney Tubular Necrosis

Disease Ontology : 12 An acute kidney failure that is characterized by necrosis of epithelial tubule cells.

MalaCards based summary : Acute Kidney Tubular Necrosis, also known as acute tubular necrosis, is related to glomerulonephritis and interstitial nephritis. An important gene associated with Acute Kidney Tubular Necrosis is MB (Myoglobin), and among its related pathways/superpathways are Renin secretion and Malaria. The drugs Lactulose and Acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and bone, and related phenotypes are cardiovascular system and cellular

Wikipedia : 74 Acute tubular necrosis (ATN) is a medical condition involving the death of tubular epithelial cells that... more...

Related Diseases for Acute Kidney Tubular Necrosis

Diseases related to Acute Kidney Tubular Necrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 357)
# Related Disease Score Top Affiliating Genes
1 glomerulonephritis 30.8 LCN2 CD40LG ALB ACE
2 interstitial nephritis 30.5 UMOD REN HAVCR1 CD40LG ALB ACE
3 liver cirrhosis 30.4 REN NPPA HGF GGT1 ALB
4 hepatitis a 30.4 HAVCR1 GGT1 ALB
5 glomerular disease 30.4 ALB ACE
6 end stage renal disease 30.4 UMOD REN CST3 ALB ACE
7 iga glomerulonephritis 30.3 REN CD40LG ALB ACE
8 typhoid fever 30.3 GGT1 CD40LG ALB
9 bilirubin metabolic disorder 30.3 GGT1 CD40LG ALB
10 alcoholic hepatitis 30.2 IL18 HGF GGT1 ALB
11 dengue hemorrhagic fever 30.2 IL18 CD40LG ALB
12 exanthem 30.2 PIK3C2A CD40LG ALB ACE
13 scrub typhus 30.2 LCN2 IL18 HAVCR1 CD40LG
14 compartment syndrome 30.1 PIK3C2A MB LCN2 ALB
15 fanconi syndrome 30.1 UMOD OGA NAGLU ALB
16 pyelonephritis 30.0 UMOD NAGLU LCN2 ALB ACE
17 deficiency anemia 30.0 NPPA MB LCN2 GGT1 ALB ACE
18 acute pyelonephritis 30.0 NAGLU LCN2 ALB ACE
19 nephrocalcinosis 29.9 UMOD REN PIK3C2A ALB
20 congestive heart failure 29.9 REN PIK3C2A NPPA ALB ACE
21 hypokalemia 29.8 REN PIK3C2A ALB ACE
22 hepatorenal syndrome 29.7 REN NPPA LCN2 IL18 HAVCR1 CST3
23 acute kidney failure 29.7 UMOD TYR REN PIK3C2A NPPA MB
24 cardiac arrest 29.6 REN PIK3C2A LCN2 ALB ACE
25 respiratory failure 29.6 REN PIK3C2A NPPA CD40LG ALB ACE
26 osteoporosis 29.4 IL18 HGF CST3 CD40LG ALB ACE
27 kidney disease 29.4 UMOD REN NPPA NAGLU LCN2 IL18
28 pericardial effusion 29.4 REN PIK3C2A NPPA CD40LG ALB ACE
29 systemic lupus erythematosus 29.3 MIR142 LCN2 IL18 HAVCR1 CST3 CD40LG
30 chronic kidney disease 29.2 UMOD REN NPPA LCN2 HGF HAVCR1
31 anuria 29.1 REN PIK3C2A MB LCN2 HAVCR1 CST3
32 acute cystitis 29.0 UMOD REN LCN2 IL18 CST3 CD40LG
33 urinary tract obstruction 28.9 UMOD REN NAGLU MIR142 LCN2 HAVCR1
34 diabetes mellitus 28.7 UMOD REN PIK3C2A LCN2 IL18 GGT1
35 hemoglobinuria 11.7
36 kidney cortex necrosis 11.4
37 progressive muscular dystrophy 10.6 NPPA MB
38 noma 10.6 IL18 ALB
39 autosomal dominant tubulointerstitial kidney disease, ren-related 10.6 UMOD REN
40 autosomal dominant tubulointerstitial kidney disease 10.6 UMOD REN
41 diffuse meningeal melanocytosis 10.6 TYR HGF
42 homocystinuria due to cystathionine beta-synthase deficiency 10.5 TYR CST3
43 spinal cord melanoma 10.5 TYR HGF
44 chronic graft versus host disease 10.5 LCN2 ALB
45 cork-handlers' disease 10.5 CD40LG ALB
46 hepatic tuberculosis 10.5 GGT1 ALB
47 vasculogenic impotence 10.5 NPPA ACE
48 fournier gangrene 10.5 CD40LG ALB
49 inferolateral myocardial infarct 10.5 LCN2 GGT1 CST3
50 heterophyiasis 10.5 CD40LG ALB

Graphical network of the top 20 diseases related to Acute Kidney Tubular Necrosis:



Diseases related to Acute Kidney Tubular Necrosis

Symptoms & Phenotypes for Acute Kidney Tubular Necrosis

MGI Mouse Phenotypes related to Acute Kidney Tubular Necrosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.28 ACE ALB CD40LG CST3 HGF IL18
2 cellular MP:0005384 10.22 ALB CD40LG CST3 GGT1 HGF IL18
3 growth/size/body region MP:0005378 10.15 ACE GGT1 HGF IL18 LCN2 MB
4 hematopoietic system MP:0005397 10.1 ACE CABIN1 CD40LG GGT1 HGF IL18
5 homeostasis/metabolism MP:0005376 10.1 ACE ALB CD40LG CST3 FABP1 GGT1
6 immune system MP:0005387 9.93 ACE ALB CABIN1 CD40LG GGT1 IL18
7 mortality/aging MP:0010768 9.83 ACE ALB CABIN1 CD40LG CST3 GGT1
8 renal/urinary system MP:0005367 9.36 ACE ALB CD40LG GGT1 LCN2 NAGLU

Drugs & Therapeutics for Acute Kidney Tubular Necrosis

Drugs for Acute Kidney Tubular Necrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 70)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lactulose Approved Phase 4 4618-18-2 11333
2
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
3
Iodine Approved, Investigational Phase 4 7553-56-2 807
4
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
5
Sofosbuvir Approved Phase 4 1190307-88-0 45375808
6 Antioxidants Phase 4
7 Respiratory System Agents Phase 4
8 Protective Agents Phase 4
9 Antidotes Phase 4
10 Expectorants Phase 4
11 N-monoacetylcystine Phase 4
12 Dialysis Solutions Phase 4
13 cadexomer iodine Phase 4
14 Sodium Potassium Chloride Symporter Inhibitors Phase 4
15 diuretics Phase 4
16 Anti-Infective Agents Phase 4
17 Insulin, Globin Zinc Phase 4
18 Antiviral Agents Phase 4
19 insulin Phase 4
20
Prednisone Approved, Vet_approved Phase 1, Phase 2 53-03-2 5865
21
Tacrolimus Approved, Investigational Phase 1, Phase 2 104987-11-3 445643 439492 6473866
22
Basiliximab Approved, Investigational Phase 1, Phase 2 152923-56-3, 179045-86-4
23
Mycophenolic acid Approved Phase 1, Phase 2 24280-93-1 446541
24
Abatacept Approved Phase 2 332348-12-6 10237
25
Clotrimazole Approved, Vet_approved Phase 2 23593-75-1 2812
26
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
27
Norepinephrine Approved Phase 2 51-41-2 439260
28
Angiotensin II Approved, Investigational Phase 2 4474-91-3, 11128-99-7, 68521-88-0 172198
29
Nitric Oxide Approved Phase 1, Phase 2 10102-43-9 145068
30
Sodium citrate Approved, Investigational Phase 2 68-04-2
31
Citric acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
32 Antitubercular Agents Phase 1, Phase 2
33 Immunosuppressive Agents Phase 1, Phase 2
34 Anti-Bacterial Agents Phase 1, Phase 2
35 Calcineurin Inhibitors Phase 1, Phase 2
36 Antibiotics, Antitubercular Phase 1, Phase 2
37 Antilymphocyte Serum Phase 1, Phase 2
38 Antifungal Agents Phase 2
39 Cyclosporins Phase 2
40 Dermatologic Agents Phase 2
41 Antirheumatic Agents Phase 2
42 Angiotensinogen Phase 2
43 Serine Proteinase Inhibitors Phase 2
44 Giapreza Phase 2
45 Vasoconstrictor Agents Phase 2
46 Immunoglobulins Phase 2
47 Antibodies Phase 2
48 Immunologic Factors Phase 2
49 Endothelium-Dependent Relaxing Factors Phase 1, Phase 2
50 Anti-Asthmatic Agents Phase 1, Phase 2

Interventional clinical trials:

(show all 40)
# Name Status NCT ID Phase Drugs
1 Phase 4 Study :Human Kidney Histopathology in Acute Obstructive Jaundice: a Prospective Study Completed NCT01090193 Phase 4
2 The Optimal Mode of Renal Replacement Therapy in Acute Kidney Injury (OMAKI) Study: A Pilot Randomized Controlled Trial of Convective Versus Diffusive Clearance Completed NCT00675818 Phase 4
3 The Efficacy of Demineralized Bone Matrix and Autogenous Bone Graft in Accelerated Fracture Healing in Closed Tibia Fracture Completed NCT00299052 Phase 4
4 Mechanisms for the Effect of Acetylcysteine on Renal Function After Exposure to Radiographic Contrast Material Completed NCT00558142 Phase 4 Acetylcysteine;Visipaque 320;Visipaque 320
5 FURosemide Stress Test to Predict Need of Renal Replacement THERapy in Ischemic Acute Tubular Necrosis in ICU Recruiting NCT03731117 Phase 4 Furosemide
6 the Prevalence of Acute Kidney Injury in Patients With Chronic Hepatitis c Virus Receiving Sofuspovir Containing Direct Acting Antiviral Therapy Recruiting NCT04267458 Phase 4
7 The Renal Safety and Rates of Acute Kidney Injury (AKI) in Patients With Chronic HCV Undergoing Sofosbuvir Containing Direct Acting Antiviral Therapy Enrolling by invitation NCT04169464 Phase 4 Sofosbuvir Oral Product
8 CSP #530 - Intensive vs. Conventional Renal Support in Acute Renal Failure Completed NCT00076219 Phase 3
9 Efficacy of N-Acetylcysteine in Prevention of Contrast-Induced Nephropathy After Cardiac Catheterization in Patients With Diabetes Mellitus and Chronic Kidney Disease: A Randomized Clinical Trial Completed NCT00808795 Phase 3 N-acetylcysteine;Placebo
10 Combination Fenoldopam Mesylate and Intravenous MESNA (2-mercaptoethane Sulphonate)in Early Acute Kidney Injury (AKD): A Randomized, Double-Blind Placebo Controlled Clinical Trial Withdrawn NCT00286403 Phase 2, Phase 3 Fenoldopam Mesylate and/or MESNA
11 Effect of Bone Marrow-derived Mesenchymal Stem Cells (BM-MSCs) on Recovery of Poor Early Graft Function Post Kidney Transplantation From Chinese Donation After Citizen Death (DCD): A Multi-center Randomized Controlled Trial Unknown status NCT02563366 Phase 1, Phase 2
12 The Efficacy and Safety of Bone Marrow-derived Mesenchymal Stem Cells in Kidney Transplantation From Chinese Donation After Citizen Death (DCD): A Multi-center Randomized Controlled Trial Unknown status NCT02561767 Phase 1, Phase 2 Induction therapy (ATG or Basiliximab);Maintenance therapy (Low-dose CNI + MPA + steroids)
13 A Randomized Trial of Early Conversion From Calcineurin Inhibitors (CNI) to Belatacept in Renal Transplant Recipients With Delayed and Slow Graft Function Unknown status NCT01837043 Phase 2 Belatacept;Calcineurin Inhibitor
14 A Pilot Crossover Randomised Controlled Trial of Angiotensin II in Critically Ill Patients With Severe Sepsis and Acute Renal Failure Unknown status NCT00711789 Phase 2 Angiotensin II;Saline placebo
15 Prevention of Renal Failure by Nitric Oxide in Prolonged Cardiopulmonary Bypass: A Double Blind Randomized Controlled Trial. Completed NCT01802619 Phase 1, Phase 2
16 A Randomized Double Blind Placebo Controlled Trial to Assess the Safety and Efficacy of Intravenous Immunoglobulin (IVIG) in Children With Japanese Encephalitis in Nepal Completed NCT01856205 Phase 2 Intravenous immunoglobulin [ImmunoRel™ (batch 20081217)]
17 A Multi-Center, Randomized, Controlled, Double-Blind, Phase II Study To Assess Safety and Efficacy With the Renal Assist Device (RAD) in Patients With Acute Renal Failure Terminated NCT00280072 Phase 2
18 A Multi-Center, Randomized, Controlled, Pivotal Study To Assess the Safety and Efficacy of A Selective Cytopheretic Device (SCD) In Patients With Acute Kidney Injury (AKI) Terminated NCT01400893 Phase 2
19 Phase I Clinical Trial, Dose-escalating Intra-aortic Infusion of Allogeneic , Bone Marrow-derived Multipotent Stromal Cells to Prevent and Treat Post-operative Acute Kidney Injury in Patients Who Require On-pump Cardiac Surgery Completed NCT00733876 Phase 1
20 A Multi-Center Pilot Study to Assess the Safety and Efficacy of A Selective Cytopheretic Device (SCD) Treatments In Patients With Acute Renal Failure (ARF) Completed NCT01072682 Phase 1
21 Neutrophile Gelatinase Associated Lipocalin Evaluation in Septic Acute Kidney Injury Unknown status NCT01122225
22 Retrospective Analysis of Renal Prognosis in Patients With Chronic Kidney Disease Unknown status NCT03201406
23 Evaluation of Renal Blood Flow Using Contrast Enhanced Ultrasound for Differential Diagnosis of Acute Kidney Injury in Cirrhotic Patients: A Pilot Study Unknown status NCT02147470 Definity ultrasound contrast agent
24 An US Mathematical Model in Predicting Renal Transplant Rejection Unknown status NCT03045731
25 Prospective Multicenter Study to Assess the Predictive Value of PIIINP and Urinary NGAL in Renal Function Recovery During Acute Tubular Necrosis Completed NCT02889575
26 Sensitivity and Specificity of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in an Emergency Room Population Completed NCT00786708
27 Urinary Cell Cycle Arrest Biomarkers as Early Predictors of Acute Kidney Injury Following Advanced Cardiac Replacement Therapies Completed NCT02827448
28 Epidemiology of Acute Kidney Injury in England - 1998 to 2013 Completed NCT02216695
29 Retrospective Study of Long-term Survival and Related Factors Among Kidney Transplant Recipients in China Completed NCT01796639
30 Non-Invasive Evaluation of Transplant Kidney Using OCT Completed NCT02084966
31 Biomarkers Neutrophil Gelatinase Associated Lipocalin, Interleukin 18 as Predictors of Acute Kidney Injury in Renal Transplant Recipients A Pilot Study Completed NCT03605264
32 Prognostic Biomarkers For Acute Kidney Injury In Liver Cirrhosis Completed NCT03156426
33 Impact of the Composition of the Packed Red Blood Cell Supernatant on Renal Dysfunction and Post-transfusion Immunomodulation Recruiting NCT02763410
34 Major Cations Targeted Fluid Therapy In Renal Transplantation. Recruiting NCT03846869
35 Renal Biopsy Findings In Patients With Unexplained Elevated Serum Creatinine In Assiut University Hospital Active, not recruiting NCT03586531
36 Optimal Clinical Predictors to Acute Kidney Injury in Cirrhotic Patients Experienced Acute Gastrointestinal Hemorrhage Enrolling by invitation NCT04184934
37 Renal Manifestations of IBD Not yet recruiting NCT04301297
38 Role of Renal Doppler Ultrasound in Early Detection of Acute Kidney Injury in Critically Ill Patients Not yet recruiting NCT03902483
39 Early Predictor of Acute Kidney Injury in Newborns With Perinatal Asphyxia Not yet recruiting NCT03617055
40 Multicentre Randomised Trial of Intermittent Versus Continuous Renal Replacement Therapy for Acute Renal Failure Terminated NCT00322933

Search NIH Clinical Center for Acute Kidney Tubular Necrosis

Cochrane evidence based reviews: kidney tubular necrosis, acute

Genetic Tests for Acute Kidney Tubular Necrosis

Anatomical Context for Acute Kidney Tubular Necrosis

MalaCards organs/tissues related to Acute Kidney Tubular Necrosis:

40
Kidney, Liver, Bone, Neutrophil, Heart, Testes, Bone Marrow

Publications for Acute Kidney Tubular Necrosis

Articles related to Acute Kidney Tubular Necrosis:

(show top 50) (show all 3287)
# Title Authors PMID Year
1
Atrial natriuretic peptide enhances recovery from ischemia/reperfusion-induced renal injury in rats. 61 54
20471588 2010
2
Atrial natriuretic peptide attenuates ischemia/reperfusion-induced renal injury by reducing neutrophil activation in rats. 54 61
18648186 2008
3
Paraphenylene diamine ingestion: an uncommon cause of acute renal failure. 54 61
17699992 2007
4
Evaluation of hepatocyte growth factor as a sensitive marker for early detection of acute renal allograft rejection. 61 54
17452892 2007
5
Acute renal failure following kidney transplantation associated with myoglobinuria in patients treated with rapamycin. 61 54
16969287 2006
6
[Diagnosis and treatment of 23 cases with rhabdomyolysis related acute renal failure]. 61 54
12857462 2003
7
Role of polymeric Tamm-Horsfall protein in cast formation: oligosaccharide and tubular fluid ions. 54 61
11231348 2001
8
Atrial natriuretic factor in oliguric acute renal failure. Anaritide Acute Renal Failure Study Group. 61 54
11007679 2000
9
Urinary N-acetyl-beta-D-glucosaminidase and neopterin aid in the diagnosis of rejection and acute tubular necrosis in initially nonfunctioning kidney grafts. 61 54
10720893 2000
10
Update on clinical trials with atrial natriuretic peptide in acute tubular necrosis. 54 61
9768436 1998
11
The rise and fall of atrial natriuretic peptide for acute renal failure. 54 61
9327207 1997
12
Diagnostic value of urinary enzyme determination in renal transplantation. 61 54
8959794 1996
13
Effect of 1-28 alpha-h atrial natriuretic peptide on acute renal failure in cadaveric renal transplantation. 54 61
8645892 1995
14
Marked enzymuria after bone marrow transplantation: a correlate of veno-occlusive disease-induced "hepatorenal syndrome". 61 54
8749694 1995
15
[Growth factors in tubular cells]. 61 54
7563623 1995
16
Uromodulin levels are decreased in urine during acute tubular necrosis but not during immune rejection after renal transplantation. 61 54
8382589 1993
17
Acute renal failure in bone marrow transplantation. 54 61
1437667 1992
18
Rhabdomyolysis associated with cocaine abuse. 61 54
1743698 1991
19
Atrial natriuretic factor does not improve the outcome of cadaveric renal transplantation. 61 54
1832982 1991
20
Rhabdomyolysis-induced acute renal failure in a child: a case report. 54 61
2259194 1990
21
Acute Kidney Injury and Electrolyte Abnormalities After Chimeric Antigen Receptor T-Cell (CAR-T) Therapy for Diffuse Large B-Cell Lymphoma. 61
31973908 2020
22
The effect of MEK1/2 inhibitors on cisplatin-induced acute kidney injury (AKI) and cancer growth in mice. 61
32194168 2020
23
Precondition your donor pig for your successful allograft! 61
32506653 2020
24
Adenosine kinase inhibition attenuates ischemia reperfusion-induced acute kidney injury. 61
32544464 2020
25
[Ischemia-reperfusion injury after kidney transplantation]. 61
32571740 2020
26
Management of acute kidney injury in COVID-19. 61
32434806 2020
27
Effects of bodybuilding supplements on the kidney: A population-based incidence study of biopsy pathology and clinical characteristics among middle eastern men. 61
32375656 2020
28
Cyclophilin A Promotes Inflammation in Acute Kidney Injury but Not in Renal Fibrosis. 61
32455976 2020
29
Acute kidney injury in pregnant women following SARS-CoV-2 infection: A case report from Iran. 61
32405454 2020
30
Carboplatin-related acute interstitial nephritis in a patient with pancreatic neuroendocrine tumor. 61
31834568 2020
31
Timing of Initiation of Renal Replacement Therapy in Sepsis-Associated Acute Kidney Injury. 61
32397637 2020
32
Acute Renal Failure/Acute Kidney Injury (AKI) Associated with Endovascular Procedures. 61
32370193 2020
33
Predictors of Renal Complications in Children With Hematotoxic Snakebite. 61
32444515 2020
34
Identification of Factors Associated With Acute Tubular Necrosis Following Kidney Transplant in Northern Mexico: Increased Risk With Cold Ischemia After 8 Hours. 61
32169365 2020
35
Dehydration-associated chronic kidney disease: a novel case of kidney failure in China. 61
32366263 2020
36
Chemokine receptor 5 blockade modulates macrophage trafficking in renal ischaemic-reperfusion injury. 61
32227583 2020
37
Toll-like receptor-2 mediates systemic inflammation in gentamicin-induced rat nephrotoxicity. 61
32384574 2020
38
Histopathological kidney changes and myoglobinuria in neotropical non-human primates attacked by dogs, Brazil. 61
31885097 2020
39
The use of plasma donor-derived, cell-free DNA to monitor acute rejection after kidney transplantation. 61
31106364 2020
40
Current status of imaging diagnosis in the transplanted kidney. A review of the literature with a special focus on contrast-enhanced ultrasonography. 61
32478319 2020
41
Continuous renal replacement therapy in critically ill patients with acute on chronic liver failure and acute kidney injury: A retrospective cohort study
. 61
32101519 2020
42
Evaluation of Renal Disease in Patients With Cirrhosis. 61
32091448 2020
43
Drug-induced tubulointerstitial nephritis: hypersensitivity and necroinflammatory pathways. 61
30820701 2020
44
Malaria and acute kidney injury. 61
30706124 2020
45
A Unique Case of Metformin-associated Severe Lactic Acidosis Without Preexisting Renal Disease: Perspectives on Prolonged Dialysis and Education for Prevention. 61
32382466 2020
46
Ferroptosis and Necroptosis in the Kidney. 61
32302582 2020
47
The Pathophysiology and Impact of Inflammation in Nonscarred Renal Interstitium: The Banff i Lesion. 61
31369519 2020
48
Utility and safety of early allograft biopsy in adult deceased donor kidney transplant recipients. 61
31768863 2020
49
Renal Protection Against Ischemia Reperfusion Injury: Hemoglobin-based Oxygen Carrier-201 Versus Blood as an Oxygen Carrier in Ex Vivo Subnormothermic Machine Perfusion. 61
31568396 2020
50
Nivolumab-induced hepatitis: A rare side effect of an immune check point inhibitor. 61
30909794 2020

Variations for Acute Kidney Tubular Necrosis

Expression for Acute Kidney Tubular Necrosis

Search GEO for disease gene expression data for Acute Kidney Tubular Necrosis.

Pathways for Acute Kidney Tubular Necrosis

Pathways related to Acute Kidney Tubular Necrosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.97 REN NPPA ACE
2 10.5 IL18 HGF CD40LG

GO Terms for Acute Kidney Tubular Necrosis

Cellular components related to Acute Kidney Tubular Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.85 UMOD REN NPPA LCN2 IL18 HGF
2 extracellular exosome GO:0070062 9.65 UMOD PIK3C2A NAGLU MB LCN2 GGT1
3 extracellular space GO:0005615 9.4 UMOD REN NPPA MIR142 LCN2 IL18

Biological processes related to Acute Kidney Tubular Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amyloid-beta metabolic process GO:0050435 9.32 REN ACE
2 positive regulation of neuroinflammatory response GO:0150078 9.26 MIR142 IL18
3 angiotensin maturation GO:0002003 9.16 REN ACE
4 cellular response to hydrogen peroxide GO:0070301 9.13 LCN2 FABP1 CST3
5 regulation of blood pressure GO:0008217 8.8 REN NPPA ACE

Molecular functions related to Acute Kidney Tubular Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 drug binding GO:0008144 9.13 FABP1 ALB ACE
2 enterobactin binding GO:1903981 8.62 LCN2 ALB

Sources for Acute Kidney Tubular Necrosis

3 CDC
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11 DGIdb
17 EFO
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32 ICD10
33 ICD10 via Orphanet
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35 IUPHAR
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57 OMIM via Orphanet
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63 QIAGEN
68 SNOMED-CT via HPO
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