MCID: ACT018
MIFTS: 28

Acute Laryngopharyngitis

Categories: Oral diseases, Respiratory diseases

Aliases & Classifications for Acute Laryngopharyngitis

MalaCards integrated aliases for Acute Laryngopharyngitis:

Name: Acute Laryngopharyngitis 12 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:11195
ICD9CM 34 465.0
SNOMED-CT 67 55355000
ICD10 32 J06.0
UMLS 71 C0155817

Summaries for Acute Laryngopharyngitis

Disease Ontology : 12 An upper respiratory tract disease which involves inflammation of both larynx and pharynx.

MalaCards based summary : Acute Laryngopharyngitis is related to danon disease and diabetic encephalopathy. An important gene associated with Acute Laryngopharyngitis is SAGE1 (Sarcoma Antigen 1), and among its related pathways/superpathways are TNFR1 Pathway and Allograft rejection. The drugs Antibiotics, Antitubercular and Anti-Bacterial Agents have been mentioned in the context of this disorder. Related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Acute Laryngopharyngitis

Graphical network of the top 20 diseases related to Acute Laryngopharyngitis:



Diseases related to Acute Laryngopharyngitis

Symptoms & Phenotypes for Acute Laryngopharyngitis

GenomeRNAi Phenotypes related to Acute Laryngopharyngitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.7 ATG12 ATG7 BECN1 CASP3 CASP7 CASP8
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.7 ATG12 ATG7 BECN1 CASP3 CASP7 CASP8

MGI Mouse Phenotypes related to Acute Laryngopharyngitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.14 ALOX5 ATG12 ATG7 BECN1 CASP3 CASP7
2 cardiovascular system MP:0005385 10.13 ABCB1 ALOX5 ATG7 BECN1 CASP3 CASP7
3 endocrine/exocrine gland MP:0005379 10.02 ABCB1 ATG7 BECN1 CASP3 CASP7 CASP8
4 growth/size/body region MP:0005378 10.02 ABCB1 ATG12 ATG7 BECN1 CASP3 CASP8
5 hematopoietic system MP:0005397 9.96 ABCB1 ALOX5 ATG7 BECN1 CASP3 CASP7
6 homeostasis/metabolism MP:0005376 9.9 ABCB1 ALOX5 ATG12 ATG7 BECN1 CASP3
7 immune system MP:0005387 9.65 ABCB1 ALOX5 ATG7 BECN1 CASP3 CASP7
8 mortality/aging MP:0010768 9.4 ABCB1 ATG12 ATG7 BECN1 CASP3 CASP7

Drugs & Therapeutics for Acute Laryngopharyngitis

Drugs for Acute Laryngopharyngitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibiotics, Antitubercular
2 Anti-Bacterial Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Use of Behavioral Economics to Improve Treatment of Acute Respiratory Infections (Main Study) Completed NCT01454947

Search NIH Clinical Center for Acute Laryngopharyngitis

Genetic Tests for Acute Laryngopharyngitis

Anatomical Context for Acute Laryngopharyngitis

Publications for Acute Laryngopharyngitis

Variations for Acute Laryngopharyngitis

Expression for Acute Laryngopharyngitis

Search GEO for disease gene expression data for Acute Laryngopharyngitis.

Pathways for Acute Laryngopharyngitis

Pathways related to Acute Laryngopharyngitis according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.77 RPS6KB1 IRS1 CASP8 CASP7 CASP3
2
Show member pathways
12.7 CASP8 CASP7 CASP3 ABCB1
3
Show member pathways
12.12 CASP8 CASP3 ALOX5
4
Show member pathways
12.11 CASP8 CASP7 CASP3
5
Show member pathways
12.04 IRS1 CASP7 CASP3
6 12.02 CASP8 CASP7 CASP3 BECN1
7 12 IRS1 CASP8 CASP3
8
Show member pathways
11.97 ULK1 RPS6KB1 IRS1
9 11.94 RPS6KB1 IRS1 CASP3
10 11.93 CASP8 CASP7 CASP3
11
Show member pathways
11.9 RPS6KB1 CASP8 CASP3
12
Show member pathways
11.85 CASP8 CASP7 CASP3
13
Show member pathways
11.84 CASP8 CASP7 CASP3
14
Show member pathways
11.82 IRS1 CASP8 CASP7 CASP3
15
Show member pathways
11.8 CASP8 CASP7 CASP3
16
Show member pathways
11.8 ULK1 BECN1 ATG7 ATG12
17 11.78 CASP8 CASP7 CASP3
18 11.76 CASP8 CASP7 CASP3
19
Show member pathways
11.61 CASP8 CASP7 CASP3
20 11.49 IRS1 CASP8 CASP3
21 11.48 ULK1 BECN1 ATG7 ATG12
22 11.41 CASP8 CASP7 CASP3
23
Show member pathways
11.3 CASP8 CASP7 CASP3
24 11.24 RPS6KB1 IRS1 CASP8
25 11.24 ULK1 RPS6KB1 IRS1 BECN1 ATG7 ATG12
26
Show member pathways
11.18 CASP8 CASP7 CASP3 BECN1
27 11.15 RPS6KB1 IRS1
28 11.15 CASP8 CASP7 CASP3
29 11.14 RPS6KB1 CASP7
30 11.09 RPS6KB1 IRS1
31
Show member pathways
11.09 CASP7 CASP3
32 10.99 CASP3 ABCB1
33
Show member pathways
10.77 RPS6KB1 IRS1
34 10.72 RPS6KB1 ABCB1
35 10.67 CASP7 CASP3

GO Terms for Acute Laryngopharyngitis

Cellular components related to Acute Laryngopharyngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.7 WDTC1 ULK1 RPS6KB1 IRS1 CASP8 CASP7
2 mitochondrial outer membrane GO:0005741 9.54 ULK1 RPS6KB1 CASP8
3 autophagosome GO:0005776 9.43 ULK1 BECN1 ATG12
4 phagophore assembly site membrane GO:0034045 9.32 ULK1 ATG12
5 death-inducing signaling complex GO:0031264 9.16 CASP8 CASP3
6 phagophore assembly site GO:0000407 8.8 ULK1 BECN1 ATG7

Biological processes related to Acute Laryngopharyngitis according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.98 RPS6KB1 CASP8 CASP7 CASP3 BECN1
2 response to lipopolysaccharide GO:0032496 9.77 RPS6KB1 CASP8 CASP3
3 aging GO:0007568 9.76 RPS6KB1 CASP7 BECN1 ATG7
4 cellular response to insulin stimulus GO:0032869 9.74 WDTC1 RPS6KB1 IRS1
5 response to glucose GO:0009749 9.72 RPS6KB1 CASP3 ATG7
6 response to nutrient levels GO:0031667 9.71 RPS6KB1 BECN1 ATG7
7 autophagy GO:0006914 9.71 ULK1 BECN1 ATG7 ATG12
8 positive regulation of autophagy GO:0010508 9.65 ULK1 BECN1 ATG7
9 response to antibiotic GO:0046677 9.61 CASP8 CASP3
10 striated muscle cell differentiation GO:0051146 9.59 CASP7 CASP3
11 cellular response to nitrogen starvation GO:0006995 9.58 BECN1 ATG7
12 positive regulation of autophagosome assembly GO:2000786 9.56 ULK1 BECN1
13 response to cobalt ion GO:0032025 9.52 CASP8 CASP3
14 autophagy of host cells involved in interaction with symbiont GO:0075044 9.51 ULK1 ATG7
15 autophagy of mitochondrion GO:0000422 9.5 BECN1 ATG7 ATG12
16 cellular response to staurosporine GO:0072734 9.49 CASP7 CASP3
17 macroautophagy GO:0016236 9.46 ULK1 BECN1 ATG7 ATG12
18 C-terminal protein lipidation GO:0006501 9.43 ATG7 ATG12
19 response to tumor necrosis factor GO:0034612 9.43 RPS6KB1 CASP8 CASP3
20 leukocyte apoptotic process GO:0071887 9.37 CASP7 CASP3
21 execution phase of apoptosis GO:0097194 9.13 CASP8 CASP7 CASP3
22 autophagosome assembly GO:0000045 8.92 ULK1 BECN1 ATG7 ATG12

Molecular functions related to Acute Laryngopharyngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.25 WDTC1 ULK1 RPS6KB1 IRS1 EHD4 CASP8
2 cysteine-type peptidase activity GO:0008234 9.58 CASP8 CASP7 CASP3
3 cysteine-type endopeptidase activity GO:0004197 9.43 CASP8 CASP7 CASP3
4 phosphatidylinositol 3-kinase binding GO:0043548 9.37 IRS1 BECN1
5 death receptor binding GO:0005123 9.32 CASP8 CASP3
6 cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097199 9.16 CASP8 CASP3
7 cysteine-type endopeptidase activity involved in execution phase of apoptosis GO:0097200 8.96 CASP7 CASP3
8 cysteine-type endopeptidase activity involved in apoptotic process GO:0097153 8.8 CASP8 CASP7 CASP3

Sources for Acute Laryngopharyngitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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