MCID: ACT018
MIFTS: 27

Acute Laryngopharyngitis

Categories: Oral diseases, Respiratory diseases

Aliases & Classifications for Acute Laryngopharyngitis

MalaCards integrated aliases for Acute Laryngopharyngitis:

Name: Acute Laryngopharyngitis 12 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:11195
ICD9CM 34 465.0
SNOMED-CT 67 55355000
ICD10 32 J06.0
UMLS 71 C0155817

Summaries for Acute Laryngopharyngitis

Disease Ontology : 12 An upper respiratory tract disease which involves inflammation of both larynx and pharynx.

MalaCards based summary : Acute Laryngopharyngitis is related to lichen planus pemphigoides and herpetiform pemphigus. An important gene associated with Acute Laryngopharyngitis is SAGE1 (Sarcoma Antigen 1), and among its related pathways/superpathways are Prolactin Signaling Pathway and Shigellosis. The drugs Anti-Bacterial Agents and Antibiotics, Antitubercular have been mentioned in the context of this disorder. Related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Acute Laryngopharyngitis

Diseases related to Acute Laryngopharyngitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
# Related Disease Score Top Affiliating Genes
1 lichen planus pemphigoides 10.4 DST COL17A1
2 herpetiform pemphigus 10.4 DST DSG1
3 linear iga disease 10.3 DST COL17A1
4 parametritis 10.3 LY96 LY86
5 neurotic excoriation 10.3 DST COL17A1
6 intestinal botulism 10.3 LY96 FBXW2
7 pompholyx 10.3 DST COL17A1
8 neurotic disorder 10.3 LY96 LY86 FBXW2
9 pemphigoid gestationis 10.3 DST DSG1 COL17A1
10 subcorneal pustular dermatosis 10.2 DST DSG1 COL17A1
11 paraneoplastic pemphigus 10.2 DST DSG1 COL17A1
12 pemphigus 10.2 DST DSG1 COL17A1
13 vesiculobullous skin disease 10.2 DST DSG1 COL17A1
14 bullous skin disease 10.2 DST DSG1 COL17A1
15 lichen disease 10.2 DST DSG1 COL17A1
16 wound botulism 10.2 LY96 FBXW2
17 lichen planus 10.2 DST DSG1 COL17A1
18 pemphigus vulgaris, familial 10.2 DST DSG1 COL17A1
19 autoimmune disease of skin and connective tissue 10.2 DST DSG1 COL17A1
20 cellulitis 10.2 DST DSG1 COL17A1
21 pemphigus foliaceus 10.1 DST DSG1
22 acute diffuse nephritis 10.1 DSG1 ABCB1
23 bullous pemphigoid 10.0 DST DSG1 COL17A1
24 danon disease 9.9 BECN1 ATG7 ATG12
25 macular degeneration, age-related, 14 9.9 BECN1 ATG12
26 tuberous sclerosis 1 9.7 ULK1 RPS6KB1 BECN1
27 tuberous sclerosis 2 9.7 ULK1 RPS6KB1 IRS1
28 mucositis 9.5 DSG1 CASP3 ABCB1
29 carbuncle 9.5 NFKBIA CASP3
30 legionellosis 9.4 NFKBIA CASP7 CASP3
31 diabetic encephalopathy 9.2 IRS1 CASP3
32 glioblastoma multiforme 8.4 RPS6KB1 NFKBIA CASP3 BECN1 ALOX5 ABCB1
33 neuroblastoma 8.3 RPS6KB1 NFKBIA CASP7 CASP3 BECN1 ABCB1

Graphical network of the top 20 diseases related to Acute Laryngopharyngitis:



Diseases related to Acute Laryngopharyngitis

Symptoms & Phenotypes for Acute Laryngopharyngitis

GenomeRNAi Phenotypes related to Acute Laryngopharyngitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.4 ATG12 BECN1 CASP3 CASP7 LY86 NFKBIA
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.4 ATG12 ATG7 CASP3 CASP7 LY86 NFKBIA

MGI Mouse Phenotypes related to Acute Laryngopharyngitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.03 ALOX5 ATG12 ATG7 BECN1 CASP3 CASP7
2 endocrine/exocrine gland MP:0005379 9.81 ABCB1 ATG7 BECN1 CASP3 CASP7 EHD4
3 hematopoietic system MP:0005397 9.77 ABCB1 ALOX5 ATG7 BECN1 CASP3 CASP7
4 immune system MP:0005387 9.4 ABCB1 ALOX5 ATG7 BECN1 CASP3 CASP7

Drugs & Therapeutics for Acute Laryngopharyngitis

Drugs for Acute Laryngopharyngitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Bacterial Agents
2 Antibiotics, Antitubercular

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Use of Behavioral Economics to Improve Treatment of Acute Respiratory Infections (Main Study) Completed NCT01454947

Search NIH Clinical Center for Acute Laryngopharyngitis

Genetic Tests for Acute Laryngopharyngitis

Anatomical Context for Acute Laryngopharyngitis

Publications for Acute Laryngopharyngitis

Variations for Acute Laryngopharyngitis

Expression for Acute Laryngopharyngitis

Search GEO for disease gene expression data for Acute Laryngopharyngitis.

Pathways for Acute Laryngopharyngitis

Pathways related to Acute Laryngopharyngitis according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.32 RPS6KB1 NFKBIA IRS1 CASP3
2 12.22 RPS6KB1 NFKBIA BECN1 ATG12
3 12.11 NFKBIA LY96 CASP7 CASP3
4
Show member pathways
12.1 RPS6KB1 IRS1 CASP3 BECN1
5 12.06 ULK1 BECN1 ATG7 ATG12
6
Show member pathways
12.03 NFKBIA IRS1 CASP7 CASP3
7
Show member pathways
12.01 NFKBIA LY96 CASP3 ALOX5
8 11.83 NFKBIA CASP7 CASP3
9 11.83 RPS6KB1 NFKBIA IRS1 CASP3
10
Show member pathways
11.82 RPS6KB1 NFKBIA IRS1
11
Show member pathways
11.65 CASP7 CASP3 BECN1
12
Show member pathways
11.64 NFKBIA CASP7 CASP3
13 11.58 LY96 CASP7 CASP3
14 11.58 ULK1 BECN1 ATG7 ATG12
15 11.51 NFKBIA IRS1 CASP3
16
Show member pathways
11.45 ULK1 BECN1 ATG7 ATG12
17 11.39 NFKBIA CASP7 CASP3
18 11.24 ULK1 RPS6KB1 IRS1 BECN1 ATG7 ATG12
19 10.99 RPS6KB1 COL17A1 CASP7
20
Show member pathways
10.8 RPS6KB1 IRS1
21 10.76 RPS6KB1 ABCB1
22 10.72 CASP7 CASP3
23 10.64 ULK1 BECN1 ATG7 ATG12

GO Terms for Acute Laryngopharyngitis

Cellular components related to Acute Laryngopharyngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.77 ULK1 RPS6KB1 NFKBIA IRS1 FBXW2 DST
2 autophagosome GO:0005776 9.43 ULK1 BECN1 ATG12
3 phagophore assembly site membrane GO:0034045 9.32 ULK1 ATG12
4 hemidesmosome GO:0030056 9.16 DST COL17A1
5 phagophore assembly site GO:0000407 8.8 ULK1 BECN1 ATG7

Biological processes related to Acute Laryngopharyngitis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.95 RPS6KB1 NFKBIA CASP7 CASP3 BECN1
2 autophagy GO:0006914 9.73 ULK1 BECN1 ATG7 ATG12
3 striated muscle cell differentiation GO:0051146 9.54 CASP7 CASP3
4 execution phase of apoptosis GO:0097194 9.52 CASP7 CASP3
5 toll-like receptor 4 signaling pathway GO:0034142 9.51 NFKBIA LY96
6 cellular response to nitrogen starvation GO:0006995 9.49 BECN1 ATG7
7 hemidesmosome assembly GO:0031581 9.48 DST COL17A1
8 positive regulation of lipopolysaccharide-mediated signaling pathway GO:0031666 9.46 LY96 LY86
9 autophagy of mitochondrion GO:0000422 9.43 BECN1 ATG7 ATG12
10 autophagy of host cells involved in interaction with symbiont GO:0075044 9.4 ULK1 ATG7
11 cellular response to staurosporine GO:0072734 9.37 CASP7 CASP3
12 C-terminal protein lipidation GO:0006501 9.32 ATG7 ATG12
13 macroautophagy GO:0016236 9.26 ULK1 BECN1 ATG7 ATG12
14 leukocyte apoptotic process GO:0071887 9.16 CASP7 CASP3
15 autophagosome assembly GO:0000045 8.92 ULK1 BECN1 ATG7 ATG12

Molecular functions related to Acute Laryngopharyngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.58 ULK1 RPS6KB1 NFKBIA LY96 LY86 IRS1
2 cysteine-type endopeptidase activity involved in apoptotic process GO:0097153 9.16 CASP7 CASP3
3 cysteine-type endopeptidase activity involved in execution phase of apoptosis GO:0097200 8.96 CASP7 CASP3

Sources for Acute Laryngopharyngitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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