MCID: ACT018
MIFTS: 24

Acute Laryngopharyngitis

Categories: Oral diseases, Respiratory diseases

Aliases & Classifications for Acute Laryngopharyngitis

MalaCards integrated aliases for Acute Laryngopharyngitis:

Name: Acute Laryngopharyngitis 12 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:11195
ICD9CM 34 465.0
SNOMED-CT 67 55355000
ICD10 32 J06.0
UMLS 71 C0155817

Summaries for Acute Laryngopharyngitis

Disease Ontology : 12 An upper respiratory tract disease which involves inflammation of both larynx and pharynx.

MalaCards based summary : Acute Laryngopharyngitis is related to pemphigoid and lichen planus pemphigoides. An important gene associated with Acute Laryngopharyngitis is DST (Dystonin), and among its related pathways/superpathways are MAPK Signaling: Mitogen Stimulation Pathway and Apoptosis and survival Caspase cascade. Related phenotypes are Increased ionizing radiation sensitivity and hematopoietic system

Related Diseases for Acute Laryngopharyngitis

Diseases related to Acute Laryngopharyngitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 pemphigoid 10.4 DST COL17A1
2 lichen planus pemphigoides 10.4 DST COL17A1
3 herpetiform pemphigus 10.3 DST DSG1
4 neurotic excoriation 10.3 DST COL17A1
5 linear iga disease 10.3 DST COL17A1
6 pompholyx 10.3 DST COL17A1
7 ecthyma 10.3 DST DSG1
8 pemphigus foliaceus 10.3 DST DSG1
9 pemphigoid gestationis 10.2 DST DSG1 COL17A1
10 subcorneal pustular dermatosis 10.2 DST DSG1 COL17A1
11 paraneoplastic pemphigus 10.2 DST DSG1 COL17A1
12 pemphigus 10.2 DST DSG1 COL17A1
13 lichen disease 10.2 DST DSG1 COL17A1
14 bullous skin disease 10.2 DST DSG1 COL17A1
15 pemphigus vulgaris, familial 10.2 DST DSG1 COL17A1
16 lichen planus 10.2 DST DSG1 COL17A1
17 pneumatosis cystoides intestinalis 10.2 SI MGAM
18 autoimmune disease of skin and connective tissue 10.2 DST DSG1 COL17A1
19 barre-lieou syndrome 10.2 SI MGAM
20 hirata disease 10.2 SI MGAM
21 miliaria 10.2 SI MGAM
22 postgastrectomy syndrome 10.2 SI MGAM
23 penis squamous cell carcinoma 10.2 COL17A1 ANXA8
24 acute diffuse nephritis 10.2 DSG1 ABCB1
25 bullous pemphigoid 10.2 DST DSG1 COL17A1
26 vulvar dystrophy 10.2 DST COL17A1
27 autoimmune disease of musculoskeletal system 10.2 DST DSG1 COL17A1
28 junctional epidermolysis bullosa 10.1 DST COL17A1 ACHE
29 trigonitis 10.1 SI MGAM
30 integumentary system disease 10.1 DST DSG1 COL17A1
31 chicken egg allergy 10.1 SI MGAM
32 macular degeneration, age-related, 14 10.1 BECN1 ATG12
33 hypothyroidism, congenital, nongoitrous, 6 10.0 CASP3 ANXA8
34 carbuncle 10.0 CASP3 ACHE
35 functional gastric disease 10.0 SI MGAM
36 danon disease 10.0 SI BECN1 ATG7
37 krabbe disease 9.9 SI MGAM CASP3
38 mucositis 9.9 DSG1 CASP3 ABCB1
39 transient cerebral ischemia 9.9 CASP3 ALOX5 ACHE
40 diabetic encephalopathy 9.9 IRS1 CASP3
41 sucrase-isomaltase deficiency, congenital 9.8 SI MGAM
42 toxic encephalopathy 9.8 CASP3 ACHE ABCB1
43 diarrhea 9.8 SI MGAM ACHE ABCB1
44 cervix carcinoma 9.7 CASP3 BECN1 ABCB1
45 palmoplantar keratoderma, bothnian type 9.5 RPS6KB1 IRS1
46 acute promyelocytic leukemia 9.5 CASP7 CASP3 ATG7 ANXA8 ABCB1
47 huntington disease 9.5 ULK1 CASP3 BECN1 ATG7 ACHE
48 tuberous sclerosis 1 9.2 ULK1 RPS6KB1 IRS1 BECN1 ATG7
49 tuberous sclerosis 2 9.1 ULK1 RPS6KB1 IRS1 BECN1 ATG7 ATG12

Graphical network of the top 20 diseases related to Acute Laryngopharyngitis:



Diseases related to Acute Laryngopharyngitis

Symptoms & Phenotypes for Acute Laryngopharyngitis

GenomeRNAi Phenotypes related to Acute Laryngopharyngitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased ionizing radiation sensitivity GR00232-A-1 8.32 RPS6KB1

MGI Mouse Phenotypes related to Acute Laryngopharyngitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.32 ABCB1 ACHE ALOX5 ATG7 BECN1 CASP3

Drugs & Therapeutics for Acute Laryngopharyngitis

Search Clinical Trials , NIH Clinical Center for Acute Laryngopharyngitis

Genetic Tests for Acute Laryngopharyngitis

Anatomical Context for Acute Laryngopharyngitis

Publications for Acute Laryngopharyngitis

Variations for Acute Laryngopharyngitis

Expression for Acute Laryngopharyngitis

Search GEO for disease gene expression data for Acute Laryngopharyngitis.

Pathways for Acute Laryngopharyngitis

Pathways related to Acute Laryngopharyngitis according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.98 RPS6KB1 IRS1 CASP3 BECN1
2
Show member pathways
11.97 IRS1 CASP7 CASP3
3 11.95 ULK1 BECN1 ATG7 ATG12
4 11.89 RPS6KB1 IRS1 CASP3
5
Show member pathways
11.76 DSG1 CASP7 CASP3
6 11.58 ULK1 BECN1 ATG7 ATG12
7
Show member pathways
11.53 CASP7 CASP3 BECN1
8
Show member pathways
11.45 ULK1 BECN1 ATG7 ATG12
9 11.24 ULK1 RPS6KB1 IRS1 BECN1 ATG7 ATG12
10 10.99 RPS6KB1 COL17A1 CASP7
11 10.91 CASP3 ABCB1
12
Show member pathways
10.71 RPS6KB1 IRS1
13 10.65 RPS6KB1 ABCB1
14 10.64 ULK1 BECN1 ATG7 ATG12
15 10.6 CASP7 CASP3
16 10.36 SI MGAM

GO Terms for Acute Laryngopharyngitis

Cellular components related to Acute Laryngopharyngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.73 ULK1 RPS6KB1 IRS1 DST DSG1 CASP7
2 apical plasma membrane GO:0016324 9.71 SI MGAM DSG1 ABCB1
3 basement membrane GO:0005604 9.5 DST COL17A1 ACHE
4 autophagosome GO:0005776 9.43 ULK1 BECN1 ATG12
5 phagophore assembly site membrane GO:0034045 9.37 ULK1 ATG12
6 hemidesmosome GO:0030056 9.16 DST COL17A1
7 phagophore assembly site GO:0000407 8.8 ULK1 BECN1 ATG7

Biological processes related to Acute Laryngopharyngitis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.88 RPS6KB1 CASP3 BECN1 ABCB1
2 autophagy GO:0006914 9.73 ULK1 BECN1 ATG7 ATG12
3 response to nutrient levels GO:0031667 9.71 RPS6KB1 BECN1 ATG7
4 aging GO:0007568 9.71 RPS6KB1 CASP7 BECN1 ATG7
5 response to wounding GO:0009611 9.7 RPS6KB1 DST CASP3
6 response to glucose GO:0009749 9.69 RPS6KB1 CASP3 ATG7
7 positive regulation of autophagy GO:0010508 9.67 ULK1 BECN1 ATG7
8 autophagosome assembly GO:0000045 9.65 BECN1 ATG7 ATG12
9 striated muscle cell differentiation GO:0051146 9.58 CASP7 CASP3
10 cellular response to nitrogen starvation GO:0006995 9.57 BECN1 ATG7
11 hemidesmosome assembly GO:0031581 9.56 DST COL17A1
12 positive regulation of autophagosome assembly GO:2000786 9.55 ULK1 BECN1
13 polysaccharide digestion GO:0044245 9.46 SI MGAM
14 autophagy of host cells involved in interaction with symbiont GO:0075044 9.37 ULK1 ATG7
15 autophagy of mitochondrion GO:0000422 9.33 BECN1 ATG7 ATG12
16 cellular response to staurosporine GO:0072734 9.32 CASP7 CASP3
17 C-terminal protein lipidation GO:0006501 9.26 ATG7 ATG12
18 leukocyte apoptotic process GO:0071887 8.96 CASP7 CASP3
19 macroautophagy GO:0016236 8.92 ULK1 BECN1 ATG7 ATG12

Molecular functions related to Acute Laryngopharyngitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol 3-kinase binding GO:0043548 9.26 IRS1 BECN1
2 cysteine-type endopeptidase activity involved in apoptotic process GO:0097153 9.16 CASP7 CASP3
3 cysteine-type endopeptidase activity involved in execution phase of apoptosis GO:0097200 8.96 CASP7 CASP3
4 alpha-1,4-glucosidase activity GO:0004558 8.62 SI MGAM

Sources for Acute Laryngopharyngitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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