Acute Laryngopharyngitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Acute Laryngopharyngitis

MalaCards integrated aliases for Acute Laryngopharyngitis:

Name: Acute Laryngopharyngitis ¹² ¹⁵ ⁷¹ ³²

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases Oral diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the respiratory system

Acute upper respiratory infections

Acute upper respiratory infections of multiple and unspecified sites

Acute laryngopharyngitis

External Ids:

Disease Ontology ¹² DOID:11195

ICD9CM ³⁴ 465.0

SNOMED-CT ⁶⁷ 55355000

ICD10 ³² J06.0

UMLS ⁷¹ C0155817

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Summaries for Acute Laryngopharyngitis

Disease Ontology : ¹² An upper respiratory tract disease which involves inflammation of both larynx and pharynx.

MalaCards based summary : Acute Laryngopharyngitis is related to pemphigoid and lichen planus pemphigoides. An important gene associated with Acute Laryngopharyngitis is DST (Dystonin), and among its related pathways/superpathways are MAPK Signaling: Mitogen Stimulation Pathway and Apoptosis and survival Caspase cascade. Related phenotypes are Increased ionizing radiation sensitivity and hematopoietic system

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Related Diseases for Acute Laryngopharyngitis

Diseases related to Acute Laryngopharyngitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)

#	Related Disease	Score	Top Affiliating Genes
1	pemphigoid	10.4	DST COL17A1
2	lichen planus pemphigoides	10.4	DST COL17A1
3	herpetiform pemphigus	10.3	DST DSG1
4	neurotic excoriation	10.3	DST COL17A1
5	linear iga disease	10.3	DST COL17A1
6	pompholyx	10.3	DST COL17A1
7	ecthyma	10.3	DST DSG1
8	pemphigus foliaceus	10.3	DST DSG1
9	pemphigoid gestationis	10.2	DST DSG1 COL17A1
10	subcorneal pustular dermatosis	10.2	DST DSG1 COL17A1
11	paraneoplastic pemphigus	10.2	DST DSG1 COL17A1
12	pemphigus	10.2	DST DSG1 COL17A1
13	lichen disease	10.2	DST DSG1 COL17A1
14	bullous skin disease	10.2	DST DSG1 COL17A1
15	pemphigus vulgaris, familial	10.2	DST DSG1 COL17A1
16	lichen planus	10.2	DST DSG1 COL17A1
17	pneumatosis cystoides intestinalis	10.2	SI MGAM
18	autoimmune disease of skin and connective tissue	10.2	DST DSG1 COL17A1
19	barre-lieou syndrome	10.2	SI MGAM
20	hirata disease	10.2	SI MGAM
21	miliaria	10.2	SI MGAM
22	postgastrectomy syndrome	10.2	SI MGAM
23	penis squamous cell carcinoma	10.2	COL17A1 ANXA8
24	acute diffuse nephritis	10.2	DSG1 ABCB1
25	bullous pemphigoid	10.2	DST DSG1 COL17A1
26	vulvar dystrophy	10.2	DST COL17A1
27	autoimmune disease of musculoskeletal system	10.2	DST DSG1 COL17A1
28	junctional epidermolysis bullosa	10.1	DST COL17A1 ACHE
29	trigonitis	10.1	SI MGAM
30	integumentary system disease	10.1	DST DSG1 COL17A1
31	chicken egg allergy	10.1	SI MGAM
32	macular degeneration, age-related, 14	10.1	BECN1 ATG12
33	hypothyroidism, congenital, nongoitrous, 6	10.0	CASP3 ANXA8
34	carbuncle	10.0	CASP3 ACHE
35	functional gastric disease	10.0	SI MGAM
36	danon disease	10.0	SI BECN1 ATG7
37	krabbe disease	9.9	SI MGAM CASP3
38	mucositis	9.9	DSG1 CASP3 ABCB1
39	transient cerebral ischemia	9.9	CASP3 ALOX5 ACHE
40	diabetic encephalopathy	9.9	IRS1 CASP3
41	sucrase-isomaltase deficiency, congenital	9.8	SI MGAM
42	toxic encephalopathy	9.8	CASP3 ACHE ABCB1
43	diarrhea	9.8	SI MGAM ACHE ABCB1
44	cervix carcinoma	9.7	CASP3 BECN1 ABCB1
45	palmoplantar keratoderma, bothnian type	9.5	RPS6KB1 IRS1
46	acute promyelocytic leukemia	9.5	CASP7 CASP3 ATG7 ANXA8 ABCB1
47	huntington disease	9.5	ULK1 CASP3 BECN1 ATG7 ACHE
48	tuberous sclerosis 1	9.2	ULK1 RPS6KB1 IRS1 BECN1 ATG7
49	tuberous sclerosis 2	9.1	ULK1 RPS6KB1 IRS1 BECN1 ATG7 ATG12

Graphical network of the top 20 diseases related to Acute Laryngopharyngitis:

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Symptoms & Phenotypes for Acute Laryngopharyngitis

GenomeRNAi Phenotypes related to Acute Laryngopharyngitis according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased ionizing radiation sensitivity	GR00232-A-1	8.32	RPS6KB1

MGI Mouse Phenotypes related to Acute Laryngopharyngitis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.32	ABCB1 ACHE ALOX5 ATG7 BECN1 CASP3

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Drugs & Therapeutics for Acute Laryngopharyngitis

Search Clinical Trials , NIH Clinical Center for Acute Laryngopharyngitis

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Genetic Tests for Acute Laryngopharyngitis

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Anatomical Context for Acute Laryngopharyngitis

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Publications for Acute Laryngopharyngitis

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Genes for Acute Laryngopharyngitis

Genes related to Acute Laryngopharyngitis (0 elite genes):

(show all 17)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	DST	Dystonin	Protein Coding	4.32	DISEASES inferred ¹⁵
2	COL17A1	Collagen Type XVII Alpha 1 Chain	Protein Coding	4.16	DISEASES inferred ¹⁵
3	DSG1	Desmoglein 1	Protein Coding	4.08	DISEASES inferred ¹⁵
4	ULK1	Unc-51 Like Autophagy Activating Kinase 1	Protein Coding	4.08	DISEASES inferred ¹⁵
5	ATG12	Autophagy Related 12	Protein Coding	3.97	DISEASES inferred ¹⁵
6	ALOX5	Arachidonate 5-Lipoxygenase	Protein Coding	3.79	DISEASES inferred ¹⁵
7	CASP7	Caspase 7	Protein Coding	3.78	DISEASES inferred ¹⁵
8	SI	Sucrase-Isomaltase	Protein Coding	3.65	DISEASES inferred ¹⁵
9	ATG7	Autophagy Related 7	Protein Coding	3.63	DISEASES inferred ¹⁵
10	MGAM	Maltase-Glucoamylase	Protein Coding	3.63	DISEASES inferred ¹⁵
11	ANXA8	Annexin A8	Protein Coding	3.6	DISEASES inferred ¹⁵
12	ACHE	Acetylcholinesterase (Cartwright Blood Group)	Protein Coding	3.58	DISEASES inferred ¹⁵
13	ABCB1	ATP Binding Cassette Subfamily B Member 1	Protein Coding	3.34	DISEASES inferred ¹⁵
14	BECN1	Beclin 1	Protein Coding	3.28	DISEASES inferred ¹⁵
15	IRS1	Insulin Receptor Substrate 1	Protein Coding	3.24	DISEASES inferred ¹⁵
16	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	3.22	DISEASES inferred ¹⁵
17	CASP3	Caspase 3	Protein Coding	3.21	DISEASES inferred ¹⁵

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Variations for Acute Laryngopharyngitis

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Expression for Acute Laryngopharyngitis

Search GEO for disease gene expression data for Acute Laryngopharyngitis.

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Pathways for Acute Laryngopharyngitis

Pathways related to Acute Laryngopharyngitis according to GeneCards Suite gene sharing:

(show all 16)

#	Super pathways	Score	Top Affiliating Genes
1	MAPK Signaling: Mitogen Stimulation Pathway ⁶⁴ Show member pathways Akt Signaling Pathway ⁶⁴	11.98	RPS6KB1 IRS1 CASP3 BECN1
2	Apoptosis and survival Caspase cascade ²³ Show member pathways Apoptosis and survival FAS signaling cascades ²³ Breakdown of the nuclear lamina ⁶⁵ Caspase cascade in apoptosis ¹ Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation ¹ FasL/ CD95L signaling ⁶⁵ Influenza A virus infection ¹	11.97	IRS1 CASP7 CASP3
3	Autophagy Pathway ⁶⁶	11.95	ULK1 BECN1 ATG7 ATG12
4	Brain-Derived Neurotrophic Factor (BDNF) signaling pathway ¹	11.89	RPS6KB1 IRS1 CASP3
5	Apoptotic cleavage of cellular proteins ⁶⁵ Show member pathways Apoptotic cleavage of cell adhesion proteins ⁶⁵ Apoptotic execution phase ⁶⁵ Caspase-mediated cleavage of cytoskeletal proteins ⁶⁵	11.76	DSG1 CASP7 CASP3
6	Senescence and Autophagy in Cancer ¹	11.58	ULK1 BECN1 ATG7 ATG12
7	Nanomaterial induced apoptosis ¹ Show member pathways Activation and oligomerization of BAK protein ⁶⁵ Apoptosis - multiple species ³⁶ Apoptosis Modulation by HSP70 ¹ Apoptotic factor-mediated response ⁶⁵ Release of apoptotic factors from the mitochondria ⁶⁵	11.53	CASP7 CASP3 BECN1
8	Macroautophagy ⁶⁵ Show member pathways Autophagy - other ³⁶	11.45	ULK1 BECN1 ATG7 ATG12
9	Autophagy - animal ³⁶	11.24	ULK1 RPS6KB1 IRS1 BECN1 ATG7 ATG12
10	a6b1 and a6b4 Integrin signaling ¹	10.99	RPS6KB1 COL17A1 CASP7
11	Gemtuzumab ozogamicin Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	10.91	CASP3 ABCB1
12	Insulin signalling in human adipocytes (diabetic condition) ¹ Show member pathways Insulin signalling in human adipocytes (normal condition) ¹	10.71	RPS6KB1 IRS1
13	Sirolimus Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	10.65	RPS6KB1 ABCB1
14	Nanoparticle triggered autophagic cell death ¹	10.64	ULK1 BECN1 ATG7 ATG12
15	ERK Pathway in Huntingtons Disease ¹	10.6	CASP7 CASP3
16	Digestion of dietary carbohydrate ⁶⁵	10.36	SI MGAM

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GO Terms for Acute Laryngopharyngitis

Cellular components related to Acute Laryngopharyngitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytosol	GO:0005829	9.73	ULK1 RPS6KB1 IRS1 DST DSG1 CASP7
2	apical plasma membrane	GO:0016324	9.71	SI MGAM DSG1 ABCB1
3	basement membrane	GO:0005604	9.5	DST COL17A1 ACHE
4	autophagosome	GO:0005776	9.43	ULK1 BECN1 ATG12
5	phagophore assembly site membrane	GO:0034045	9.37	ULK1 ATG12
6	hemidesmosome	GO:0030056	9.16	DST COL17A1
7	phagophore assembly site	GO:0000407	8.8	ULK1 BECN1 ATG7

Biological processes related to Acute Laryngopharyngitis according to GeneCards Suite gene sharing:

(show all 19)

#	Name	GO ID	Score	Top Affiliating Genes
1	response to drug	GO:0042493	9.88	RPS6KB1 CASP3 BECN1 ABCB1
2	autophagy	GO:0006914	9.73	ULK1 BECN1 ATG7 ATG12
3	response to nutrient levels	GO:0031667	9.71	RPS6KB1 BECN1 ATG7
4	aging	GO:0007568	9.71	RPS6KB1 CASP7 BECN1 ATG7
5	response to wounding	GO:0009611	9.7	RPS6KB1 DST CASP3
6	response to glucose	GO:0009749	9.69	RPS6KB1 CASP3 ATG7
7	positive regulation of autophagy	GO:0010508	9.67	ULK1 BECN1 ATG7
8	autophagosome assembly	GO:0000045	9.65	BECN1 ATG7 ATG12
9	striated muscle cell differentiation	GO:0051146	9.58	CASP7 CASP3
10	cellular response to nitrogen starvation	GO:0006995	9.57	BECN1 ATG7
11	hemidesmosome assembly	GO:0031581	9.56	DST COL17A1
12	positive regulation of autophagosome assembly	GO:2000786	9.55	ULK1 BECN1
13	polysaccharide digestion	GO:0044245	9.46	SI MGAM
14	autophagy of host cells involved in interaction with symbiont	GO:0075044	9.37	ULK1 ATG7
15	autophagy of mitochondrion	GO:0000422	9.33	BECN1 ATG7 ATG12
16	cellular response to staurosporine	GO:0072734	9.32	CASP7 CASP3
17	C-terminal protein lipidation	GO:0006501	9.26	ATG7 ATG12
18	leukocyte apoptotic process	GO:0071887	8.96	CASP7 CASP3
19	macroautophagy	GO:0016236	8.92	ULK1 BECN1 ATG7 ATG12

Molecular functions related to Acute Laryngopharyngitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	phosphatidylinositol 3-kinase binding	GO:0043548	9.26	IRS1 BECN1
2	cysteine-type endopeptidase activity involved in apoptotic process	GO:0097153	9.16	CASP7 CASP3
3	cysteine-type endopeptidase activity involved in execution phase of apoptosis	GO:0097200	8.96	CASP7 CASP3
4	alpha-1,4-glucosidase activity	GO:0004558	8.62	SI MGAM

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Sources for Acute Laryngopharyngitis

¹ BioSystems

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³ CDC

⁴ Cell Signaling Technology

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⁴⁸ NCBI Bookshelf

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⁵¹ NDF-RT

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⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

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⁷¹ UMLS

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⁷⁴ Wikipedia