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MCID: ACT073
MIFTS: 62

Acute Leukemia

Categories: Blood diseases, Bone diseases, Cancer diseases, Immune diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Acute Leukemia

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MalaCards integrated aliases for Acute Leukemia:

Name: Acute Leukemia 39 12 30 56 15 17 74
Acute Undifferentiated Leukemia 74
Undifferentiated Leukemia 74
Stem Cell Leukaemia 12
Stem Cell Leukemia 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Blood diseases Immune diseases Bone diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:12603
ICD9CM 36 208.0
NCIt 51 C9300
SNOMED-CT 69 24072005 91855006
ICD10 34 C95.0 C95.00
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Summaries for Acute Leukemia

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Disease Ontology : 12 A leukemia that occurs when a hematopoietic stem cell undergoes malignant transformation into a primitive, undifferentiated cell with abnormal longevity. These lymphocytes (acute lymphocytic leukemia [ALL]) or myeloid cells (acute myelocytic leukemia [AML]) proliferate abnormally, replacing normal marrow tissue and hematopoietic cells and inducing anemia, thrombocytopenia, and granulocytopenia.

MalaCards based summary : Acute Leukemia, also known as acute undifferentiated leukemia, is related to megakaryocytic leukemia and childhood leukemia. An important gene associated with Acute Leukemia is BAALC (BAALC Binder Of MAP3K1 And KLF4), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Arsenic trioxide and Amphotericin B have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow, and related phenotypes are no effect and Reduced mammosphere formation

Wikipedia : 77 Acute leukemia or acute leukaemia is a family of serious medical conditions relating to an original... more...

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Related Diseases for Acute Leukemia

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Diseases in the Leukemia family:

Acute Leukemia Chronic Leukemia
Subacute Leukemia

Diseases related to Acute Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 439)
# Related Disease Score Top Affiliating Genes
1 megakaryocytic leukemia 32.5 JAK2 MPO RUNX1
2 childhood leukemia 32.4 ETV6 KMT2A MLLT3 MTHFR RUNX1
3 acute lymphocytic leukemia 32.3 CSF3 ETV6 GSTM1 MTHFR RUNX1
4 lymphoblastic lymphoma 32.2 DNTT KMT2A MPO
5 leukemia, acute lymphoblastic 32.2 AFF1 ANPEP DNTT ETV6 FLT3 KMT2A
6 leukemia 32.2 BAALC CEBPA CREBBP ETV6 FLT3 JAK2
7 acute promyelocytic leukemia 32.0 ANPEP CD34 CEBPA CSF3 FLT3 MPO
8 lymphocytic leukemia 30.9 DNTT ETV6 KMT2A RUNX1
9 leukemia, acute myeloid 30.8 AFF1 ANPEP BAALC CD34 CEBPA CSF3
10 myeloid leukemia 30.5 CEBPA CREBBP ETV6 FLT3 JAK2 KIT
11 aplastic anemia 30.3 CD34 CSF3 FLT3 GSTM1
12 lymphoid leukemia 30.3 ETV6 FLT3 JAK2 KMT2A
13 chronic myelomonocytic leukemia 30.2 ETV6 FLT3 JAK2 KIT RUNX1
14 myelodysplastic syndrome 30.1 ANPEP CD34 CEBPA CREBBP CSF3 DNTT
15 myeloma, multiple 30.1 CD34 CSF3 JAK2 KIT
16 8p11 myeloproliferative syndrome 29.9 FLT3 KIT RUNX1
17 chronic eosinophilic leukemia 29.9 FLT3 KIT WT1
18 cytogenetically normal acute myeloid leukemia 29.8 CEBPA FLT3 KMT2A WT1
19 acute erythroid leukemia 29.8 CEBPA JAK2
20 acute lymphoblastic leukemia, childhood 29.8 ETV6 GSTM1 MTHFR RUNX1
21 myeloid sarcoma 29.7 ANPEP DNTT FLT3 KIT KMT2A MPO
22 myelofibrosis 29.7 CD34 CSF3 FLT3 JAK2 KIT
23 lymphoma, non-hodgkin, familial 29.7 CD34 CSF3 DNTT JAK2
24 gastrointestinal stromal tumor 29.4 CD34 FLT3 KIT MTHFR
25 leukemia, chronic myeloid 28.9 CD34 CSF3 DNTT ETV6 FLT3 JAK2
26 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 28.7 CREBBP DNTT ETV6 FLT3 KIT KMT2A
27 bone marrow cancer 28.5 ANPEP CD34 CSF3 ETV6 FLT3 JAK2
28 acute leukemia of ambiguous lineage 12.4
29 bilineal acute leukemia 12.2
30 chromosome 8p11 myeloproliferative syndrome 11.9
31 invasive aspergillosis 11.4
32 chronic leukemia 11.4
33 myelodysplastic myeloproliferative cancer 11.0
34 severe congenital neutropenia 11.0
35 myeloproliferative neoplasm 11.0
36 mthfr gene variant 11.0
37 hematopoietic stem cell transplantation 10.6
38 lymphoma 10.5
39 acute myeloid leukemia with t(9;11)(p22;q23) 10.5 KMT2A MLLT3
40 subacute myeloid leukemia 10.5 FLT3 JAK2
41 ring chromosome 21 10.5 ETV6 KMT2A
42 chromophobe renal cell carcinoma 10.5
43 renal oncocytoma 10.5
44 acute myeloblastic leukemia with maturation 10.5 FLT3 KIT
45 testicular gonadoblastoma 10.5 KIT WT1
46 b-cell childhood acute lymphoblastic leukemia 10.4 ETV6 RUNX1
47 acute myeloid leukemia with minimal differentiation 10.4 FLT3 MPO
48 nondisjunction 10.4 KIT MTHFR
49 blood coagulation disease 10.4 CSF3 JAK2 MTHFR
50 congenital mesoblastic nephroma 10.4 ETV6 KIT WT1

Comorbidity relations with Acute Leukemia via Phenotypic Disease Network (PDN):


Deficiency Anemia Neutropenia

Graphical network of the top 20 diseases related to Acute Leukemia:



Diseases related to Acute Leukemia
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Symptoms & Phenotypes for Acute Leukemia

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GenomeRNAi Phenotypes related to Acute Leukemia according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.26 AFF1 ANPEP BAALC CD34 CEBPA CREBBP
2 Reduced mammosphere formation GR00396-S 9.17 CD34 CEBPA CSF3 ETV6 GSTM1 KMT2A

MGI Mouse Phenotypes related to Acute Leukemia:

47 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.38 AFF1 ANPEP CD34 CEBPA CREBBP CSF3
2 immune system MP:0005387 10.34 AFF1 ANPEP CD34 CEBPA CREBBP CSF3
3 homeostasis/metabolism MP:0005376 10.3 CD34 CEBPA CREBBP DNTT ETV6 FLT3
4 growth/size/body region MP:0005378 10.27 AFF1 CEBPA CREBBP ETV6 FLT3 JAK2
5 cardiovascular system MP:0005385 10.24 ANPEP CEBPA CREBBP ETV6 KIT KMT2A
6 endocrine/exocrine gland MP:0005379 10.21 AFF1 ANPEP CEBPA CREBBP ETV6 FLT3
7 integument MP:0010771 10.14 ANPEP CD34 CEBPA CREBBP CSF3 ETV6
8 embryo MP:0005380 10.13 CREBBP ETV6 JAK2 KIT KMT2A MLLT3
9 mortality/aging MP:0010768 10.13 AFF1 CEBPA CREBBP ETV6 FLT3 JAK2
10 liver/biliary system MP:0005370 9.97 CEBPA CREBBP JAK2 KIT KMT2A MTHFR
11 neoplasm MP:0002006 9.9 CD34 CEBPA CREBBP ETV6 FLT3 JAK2
12 muscle MP:0005369 9.8 CEBPA CREBBP KIT KMT2A MPO STMN1
13 no phenotypic analysis MP:0003012 9.65 AFF1 CEBPA ETV6 FLT3 KIT KMT2A
14 normal MP:0002873 9.32 CEBPA CREBBP DNTT ETV6 JAK2 KIT
Sources

Drugs & Therapeutics for Acute Leukemia

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Drugs for Acute Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 462)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Arsenic trioxide Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 1327-53-3 518740
2
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2 1397-89-3 14956 5280965
3
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 1177-87-3
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
6
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 2068-78-2, 57-22-7 5978
7
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 75607-67-9, 21679-14-1 30751
8
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 135968-09-1
9
Sargramostim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 123774-72-1, 83869-56-1
10
Cytarabine Approved, Experimental, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 147-94-4, 65-46-3 6253
11
Busulfan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 55-98-1 2478
12
Vidarabine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 24356-66-9 21704 32326
13
Mycophenolic acid Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 24280-93-1 446541
14
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 6055-19-2, 50-18-0 2907
15
Posaconazole Approved, Investigational, Vet_approved Phase 4,Phase 2 171228-49-2 147912
16
Micafungin Approved, Investigational Phase 4,Phase 2 235114-32-6 477468 3081921
17 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Phase 1
18 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
19 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
20 Cytochrome P-450 CYP2C9 Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
21 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Phase 1
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
23 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
24 Liposomal amphotericin B Phase 4,Phase 3,Phase 2
25 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
26 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
27 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
29 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
30 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
31 Antimitotic Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
32 Antiemetics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
33 Antineoplastic Agents, Phytogenic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
34 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
35 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
37 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
38 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
39
protease inhibitors Phase 4,Phase 3,Phase 2,Phase 1
40 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 BB 1101 Phase 4,Phase 3,Phase 2,Phase 1
42 Antimetabolites Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
43 Immunosuppressive Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
44 Adjuvants, Immunologic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Antineoplastic Agents, Alkylating Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
46 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
47 Thymoglobulin Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Alkylating Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
49 Immunologic Factors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
50 Antimetabolites, Antineoplastic Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 625)
# Name Status NCT ID Phase Drugs
1 Treatment Protocol for Relapsed Acute Promyelocytic Leukemia (APL) With Arsenic Unknown status NCT00196768 Phase 4 Arsenic trioxide;Trisenox
2 PROPHYSOME: Pilot Study on Safety of a Weekly Administration of 10mg/kg of AmBisome® in Antifungal Prophylaxis Treatment of Allogeneic Stem-cell Transplantation and Acute Leukaemia Completed NCT00362544 Phase 4 Ambisome
3 Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome Completed NCT01200355 Phase 4 micafungin;posaconazole
4 Treatment of Relapsed Promyelocytic Leukemia With Arsenic Trioxide (ATO) Completed NCT00504764 Phase 4 Arsenic Trioxide;ATRA
5 Pulses of Vincristine and Dexamethasone in BFM Protocols for Children With Acute Lymphoblastic Leukemia Completed NCT00411541 Phase 4 vincristine;dexamethasone
6 Study of Busulfan and FLAG Conditioning Regimen for Allogeneic Peripheral Blood Stem Cell Transplantation Not yet recruiting NCT02784561 Phase 4 Busulfan (Zhejiang Otsuka Pharmaceutical Co. Ltd);Cytarabine(Actavis Italy S.p.A);Fludarabine (Bayer);granulocyte colony-stimulating factor (KirinKunpeng);rabbit ATG（Sanofi/Genzyme）
7 Combination of Thrombopoietin Mimetic and Immunosuppressive Therapy in Aplastic Anaemia Not yet recruiting NCT03896971 Phase 4 Combination of thrombopoietin mimetic and cyclosporin A
8 A Optimal Anti-Thymoglobuline (ATG) Dose Decrease cGVHD But Not Increase Leukemia Relapse for Haplo-HSCT Not yet recruiting NCT03190733 Phase 4 ATG
9 Busulfan and Cyclophosphamide Instead of Total Boby Irradiation (TBI) and Cyclophosphamide for Hematological Malignancies Hematocrit (HCT) Not yet recruiting NCT01339988 Phase 4 Busulfan/Cyclophosphamide
10 ProphyALL - Study on the Safety of Liposomal Amphotericin B to Prevent Antifungal Infections in Elderly Patients With Acute Lymphoblastic Leukemia Terminated NCT00386997 Phase 4 liposomal amphotericin B (AmBisome®)
11 Antifungal Prophylaxis in Pediatric Acute Leukemia Unknown status NCT00624143 Phase 3 ORAL VORICONAZOLE and IV Amphotericin B
12 A Study Comparing Single Versus Double Umbilical Cord Blood Transplantation in the Young With Acute Leukemia Remission Unknown status NCT01067300 Phase 3
13 Megakaryocytic Progenitor Cells for Prophylaxis and Treatment of Thrombocytopenia Unknown status NCT02241031 Phase 2, Phase 3 thrombopoietin (TPO) and interleukin-11
14 Transfusion Strategy in Hematological Intensive Care Unit Unknown status NCT02461264 Phase 3 Single red blood packed cells Transfusion;Two packed red blood cells Transfusion
15 MRD-directed Donor Lymphocyte Infusion for Reduce of Relapse After Allo-HSCT Unknown status NCT02673008 Phase 2, Phase 3
16 Decitabine Augments for Post Allogeneic Stem Cell Transplantation in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndrome Unknown status NCT01809392 Phase 2, Phase 3 decitabine
17 Evaluation of Plasmatic Levels of Busulfan in Patients Undergoing Hematopoietic Stem Cell Transplantation Unknown status NCT01800643 Phase 2, Phase 3
18 Thymoglobulin in Unrelated Hematopoietic Progenitor Cell Transplantation Unknown status NCT01217723 Phase 3
19 Pegylated Liposomal Doxorubicin Versus Daunorubicin to Treat Acute Lymphoblastic Leukemia: Unknown status NCT02070523 Phase 3 VDCLD regimen
20 Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain Unknown status NCT01316744 Phase 3 ketamine hydrochloride
21 Levofloxacin Compared With Cefepime in Treating Cancer Patients With Fever and Neutropenia Unknown status NCT00020865 Phase 3 cefepime hydrochloride;levofloxacin
22 Combination Chemotherapy Plus Steroid Therapy in Treating Children With Acute Lymphoblastic Leukemia or Lymphoblastic Non-Hodgkin's Lymphoma Unknown status NCT00003728 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;leucovorin calcium;mercaptopurine;methotrexate;methylprednisolone;mitoxantrone hydrochloride;prednisolone;therapeutic hydrocortisone;thioguanine;vincristine sulfate;vindesine
23 Clove In The Treatment Of Relapsed Or Resistant Acute Leukemia In Children Completed NCT01385891 Phase 2, Phase 3 Clofarabine VP 16 ciclophospahamide
24 Levofloxacin in Preventing Infection in Young Patients With Acute Leukemia Receiving Chemotherapy or Undergoing Stem Cell Transplantation Completed NCT01371656 Phase 3 levofloxacin
25 Chronic Graft-versus-host Disease (cGvHD) Prophylaxis With or Without ATG Prior to Stem Cell Transplantation (SCT) From HLA-identical Siblings in Patients With Acute Leukemia Completed NCT00678275 Phase 3 ATG FRESENIUS (Anti-Lymphocyte-Globulin);ATG FRESENIUS (Anti-Lymphocyte-Globulin)
26 Bone Marrow Transplantation in Treating Patients With Acute Leukemia in First or Second Remission Completed NCT00002534 Phase 3 cyclophosphamide;cytarabine;methylprednisolone;thiotepa
27 Peripheral Blood (PB) Versus Bone Marrow (BM) in Allogeneic Stem Cell Transplantation Completed NCT01020175 Phase 3
28 Busulfan Plus Cyclophosphamide vs Fludarabine as a Conditioning Regimen Completed NCT00774280 Phase 3 BuCy vs BuFlu
29 Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Acute Lymphoblastic Leukemia Completed NCT00002700 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;mitoxantrone hydrochloride;prednisolone;prednisone;therapeutic hydrocortisone;vincristine sulfate
30 Treatment of Acute Myeloid Leukemia (AML) in Adults 50 to 70 Years, Study of Two Anthracyclines and the Interest of Maintenance Treatment With Interleukin 2 Completed NCT00931138 Phase 3 chemotherapy (Aracytine + Daunorubicin);chemotherapy (Aracytine + Daunorubicin);chemotherapy (Aracytine + Daunorubicin)
31 A Randomized Study of Gemtuzumab Ozogamicin (GO) With Daunorubicine and Cytarabine in Untreated Acute Myeloid Leukemia (AML) Aged of 50-70 Years Old Completed NCT00927498 Phase 3 conventional chemotherapy (AraC + Daunorubicin),;Mylotarg associated with conventional chemotherapy (AraC + Daunorubicin),
32 Effect of Priming During Induction and Consolidations in Younger Acute Myeloid Leukemia (AML) Completed NCT00880243 Phase 3 GM-CSF
33 A Multicentre Randomised Controlled Trial Comparing Two Strategies for the Diagnosis of Invasive Aspergillosis in High-risk Haematology Patients Completed NCT00163722 Phase 3
34 Tipifarnib Versus Best Supportive Care in the Treatment of Newly Diagnosed Acute Myeloid Leukemia (AML) Completed NCT00093990 Phase 3 Tipifarnib;Zarnestra; R115777
35 Timed-Sequential Induction in CBF-AML Completed NCT00428558 Phase 3 Chemotherapy (DAUNORUBICINE-CYTARABINE);Chemotherapy (DAUNORUBICINE-CYTARABINE)
36 Efficacy/Safety of Frontline Alemtuzumab (Campath, MabCampath) vs Chlorambucil in Patients With Progressive B-Cell Lymphocytic Leukemia Completed NCT00046683 Phase 3 alemtuzumab
37 Prevention of Left Ventricular Dysfunction During Chemotherapy Completed NCT01110824 Phase 3 Enalapril and carvedilol
38 Combination Chemotherapy With or Without Lestaurtinib in Treating Younger Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed NCT00557193 Phase 3 Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin Hydrochloride;Dexamethasone;Etoposide;Lestaurtinib;Leucovorin Calcium;Mercaptopurine;Methotrexate;Methylprednisolone;Pegaspargase;Prednisone;Therapeutic Hydrocortisone;Vincristine Sulfate
39 Personalized Information or Basic Information in Helping Patients Make Decisions About Participating in a Clinical Trial Completed NCT00750009 Phase 3
40 American Ginseng in Treating Patients With Fatigue Caused by Cancer Completed NCT00719563 Phase 3 American ginseng
41 Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain Completed NCT00666211 Phase 3
42 Darbepoetin Alfa With or Without Iron in Treating Anemia Caused By Chemotherapy in Patients With Cancer Completed NCT00661999 Phase 3 sodium ferric gluconate complex in sucrose
43 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
44 Dalteparin to Prevent Complications in Cancer Patients Receiving Chemotherapy Through a Catheter Completed NCT00006083 Phase 3 Fragmin
45 Bone Marrow Transplantation in Treating Patients With Leukemia, Myelodysplasia, or Lymphoblastic Lymphoma Completed NCT00003187 Phase 2, Phase 3 cyclophosphamide;cyclosporine;cytarabine;methotrexate;methylprednisolone
46 Ondansetron in Treating Patients With Advanced Cancer and Chronic Nausea and Vomiting Not Caused by Cancer Treatment Completed NCT00006348 Phase 3 ondansetron
47 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
48 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
49 Treatment for Chronic Pain in Patients With Advanced Cancer Completed NCT00003687 Phase 3 dextromethorphan hydrobromide;morphine sulfate
50 Decitabine+BUCY vs BUCY Conditioning Regimen for MLL+ Acute Leukemia Undergoing Allo-HSCT Recruiting NCT03596892 Phase 2, Phase 3 Decitabine;Busulfan (BU);Cyclophosphamide (CY)

Search NIH Clinical Center for Acute Leukemia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Acute Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Acute Leukemia:
Promostem�, mesenchymal stem cells for treatment of graft-versus-host disease
Sources

Genetic Tests for Acute Leukemia

About this section

Genetic tests related to Acute Leukemia:

# Genetic test Affiliating Genes
1 Acute Leukemia 30
Sources

Anatomical Context for Acute Leukemia

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MalaCards organs/tissues related to Acute Leukemia:

42
Myeloid, Bone, Bone Marrow, T Cells, B Cells, Nk Cells, Testes
Sources

Publications for Acute Leukemia

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Articles related to Acute Leukemia:

(show top 50) (show all 3697)
# Title Authors Year
1
Very rare lineage switch from acute myeloid leukemia to mixed phenotype acute leukemia, B/Myeloid, during chemotherapy with no clonal evolution. ( 30707502 )
2019
2
Mouse acute leukemia develops independent of self-renewal and differentiation potentials in hematopoietic stem and progenitor cells. ( 30733302 )
2019
3
Long Non-Coding RNA and Acute Leukemia. ( 30744139 )
2019
4
Analytical performance of automated platelet counts and impact on platelet transfusion guidance in patients with acute leukemia. ( 30761915 )
2019
5
Concomitant use of blinatumomab and donor lymphocyte infusion for mixed-phenotype acute leukemia: a case report with literature review. ( 30786841 )
2019
6
'Acute leukemia in congenital methehemoglobinemia - an enigma to explore'. ( 30788079 )
2019
7
Sorafenib improves survival of FLT3-mutated acute myeloid leukemia in relapse after allogeneic stem cell transplantation: a report of EBMT acute leukemia Working Party. ( 30792203 )
2019
8
Doripenem versus meropenem as first-line empiric therapy of febrile neutropenia in patients with acute leukemia: a prospective, randomized study. ( 30824955 )
2019
9
Audit of Quality and Quantity of Nucleic Acid Yield from Pediatric Acute Leukemia Cases Following a Bio-banking Initiative. ( 30828152 )
2019
10
Mixed Phenotype Acute Leukemia, B/Myeloid with t(9;22): Diagnostic and Therapeutic Challenges. ( 30828170 )
2019
11
Psychosocial Experiences of Young Adults Diagnosed With Acute Leukemia During Hospitalization for Induction Chemotherapy Treatment. ( 30829935 )
2019
12
Correction to: Minimal residual disease- and graft-vs.-host disease-guided multiple consolidation chemotherapy and donor lymphocyte infusion prevent second acute leukemia relapse after allotransplant. ( 30836977 )
2019
13
Lipodystrophy-like features after total body irradiation among survivors of childhood acute leukemia. ( 30844749 )
2019
14
Spectrum and Immunophenotypic Profile of Acute Leukemia: A Tertiary Center Flow Cytometry Experience. ( 30858955 )
2019
15
ATP-Binding Cassette transporters' gene expression in pediatric patients with acute leukemia; a comprehensive analysis of published reports through PubMed search engine. ( 30860475 )
2019
16
Acute leukemia in a patient with 15q overgrowth syndrome. ( 30861314 )
2019
17
Identification of chromosomal abnormalities and genomic features in near-triploidy/tetraploidy-acute leukemia by fluorescence in situ hybridization. ( 30863166 )
2019
18
Checkpoint inhibition of PD-L1 and CTLA-4 in a child with refractory acute leukemia. ( 30863527 )
2019
19
High rates of ovarian function preservation after hematopoietic cell transplantation with melphalan-based reduced intensity conditioning for pediatric acute leukemia: an analysis from the Japan Association of Childhood Leukemia Study (JACLS). ( 30864117 )
2019
20
Mixed-phenotype acute leukemia with t(4;11)(q21;q23) KMT2A-AFF1-rearranged. ( 30872272 )
2019
21
Efficacy of levofloxacin as an antibacterial prophylaxis for acute leukemia patients receiving intensive chemotherapy: a systematic review and meta-analysis. ( 30880638 )
2019
22
Ophthalmic Manifestations of Acute Leukemia. ( 30891378 )
2019
23
Association between NAT2 polymorphisms and acute leukemia risk: A meta-analysis. ( 30896661 )
2019
24
Staging of acute leukemia based on central nervous system involvement alone: Is it appropriate? ( 30900807 )
2019
25
Nasal embryonal rhabdomyosarcoma with bone marrow metastasis simulating acute leukemia: A case report and review of the literature. ( 30902383 )
2019
26
Outcomes after Second Hematopoietic Cell Transplantation in Children and Young Adults with Relapsed Acute Leukemia. ( 30244103 )
2019
27
Peripheral blood flow cytometry for the diagnosis of pediatric acute leukemia: Highly reliable with rare exceptions. ( 30255571 )
2019
28
Initial Diagnostic Work-Up of Acute Leukemia: ASCO Clinical Practice Guideline Endorsement of the College of American Pathologists and American Society of Hematology Guideline. ( 30523709 )
2019
29
Clinically useful flow cytometry approach to identify immunophenotype in acute leukemia. ( 30614357 )
2019
30
Early Deaths in Pediatric Acute Leukemia: A Major Challenge in Developing Countries. ( 30615014 )
2019
31
Therapeutic granulocyte transfusions: neutropenic patients with acute leukemia continue to need them - why are definitive evidence-based practice guidelines elusive? ( 30615809 )
2019
32
Increased Health Care Utilization and Costs in Allogeneic Hematopoietic Cell Transplantation for Acute Leukemia and Myelodysplastic Syndromes in Adolescents and Young Adults Compared with Children: A Multicenter Study. ( 30625391 )
2019
33
Challenges in Clinical Metaproteomics Highlighted by the Analysis of Acute Leukemia Patients with Gut Colonization by Multidrug-Resistant Enterobacteriaceae. ( 30626002 )
2019
34
Effect of laminar air flow and building construction on aspergillosis in acute leukemia patients: a retrospective cohort study. ( 30626352 )
2019
35
Impacts of thymoglobulin in patients with acute leukemia in remission undergoing allogeneic HSCT from different donors. ( 30626574 )
2019
36
Small molecule inhibitor of c-Myc 10058-F4 inhibits proliferation and induces apoptosis in acute leukemia cells, irrespective of PTEN status. ( 30639430 )
2019
37
Bloodstream infection (BSI) due to Vancomycin-Resistant Enterococcus (VRE) is associated with increased mortality after hematopoietic cell transplantation for acute leukemia and myelodysplastic syndrome: A multicenter, retrospective cohort study. ( 30649224 )
2019
38
Memantine potentiates cytarabine-induced cell death of acute leukemia correlating with inhibition of Kv1.3 potassium channels, AKT and ERK1/2 signaling. ( 30651113 )
2019
39
Resolution of celiac disease, IgA deficiency and platelet refractoriness after allogeneic bone marrow transplantation for acute leukemia. ( 30655374 )
2019
40
Mathematical models of amino acid panel for assisting diagnosis of children acute leukemia. ( 30674317 )
2019
41
Targeted Polo-like Kinase Inhibition Combined With Aurora Kinase Inhibition in Pediatric Acute Leukemia Cells. ( 30702467 )
2019
42
Acute leukemia cells resistant to PI3K/mTOR inhibition display upregulation of P2RY14 expression. ( 29951132 )
2018
43
Comparable survival using a CMV-matched or a mismatched donor for CMV+ patients undergoing T-replete haplo-HSCT with PT-Cy for acute leukemia: a study of behalf of the infectious diseases and acute leukemia working parties of the EBMT. ( 29330396 )
2018
44
Association between (GT)n Repeats in Heme Oxygenase-1 Gene Promoter and 3-Year Survival of Patients with Acute Leukemia: a Controlled, Cross-Sectional Study. ( 29951178 )
2018
45
Impact of antithymocyte globulin doses in reduced intensity conditioning before allogeneic transplantation from matched sibling donor for patients with acute myeloid leukemia: a report from the acute leukemia working party of European group of Bone Marrow Transplantation. ( 29330391 )
2018
46
Risk factors for mortality in patients with acute leukemia and bloodstream infections in the era of multiresistance. ( 29953464 )
2018
47
Maternal Exposure to Pesticides, Paternal Occupation in the Army/Police Force, and CYP2D6*4 Polymorphism in the Etiology of Childhood Acute Leukemia. ( 29432309 )
2018
48
Re-induction chemotherapy using FLAG-mitoxantrone for adult patients with relapsed acute leukemia: a single-center experience from United Arab Emirates. ( 29951735 )
2018
49
Determination of CEBPA mutations by next generation sequencing in pediatric acute leukemia. ( 29947237 )
2018
50
Fibroblast Growth Factor 23-Induced Hypophosphatemia in Acute Leukemia. ( 29696242 )
2018
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Variations for Acute Leukemia

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Expression for Acute Leukemia

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Search GEO for disease gene expression data for Acute Leukemia.
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Pathways for Acute Leukemia

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Pathways related to Acute Leukemia according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Endometrial cancer 38
Show member pathways
 12.66 CEBPA CREBBP FLT3 KIT MPO RUNX1
2
Pathways in cancer 38
12.59 CEBPA CREBBP FLT3 GSTM1 JAK2 KIT
3
NF-kappaB Signaling 4
12.36 CD34 CEBPA JAK2 KIT MPO RUNX1
4
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.8 ANPEP CD34 CSF3 FLT3 KIT MPO
5
Hematopoietic cell lineage 38
11.62 ANPEP CD34 CSF3 DNTT FLT3 KIT
6
Innate Lymphoid Cell Differentiation Pathways 66
11.59 CD34 KIT RUNX1
7
Transcriptional misregulation in cancer 38
11.55 AFF1 CEBPA ETV6 FLT3 KMT2A MLLT3
8
Dendritic Cells Developmental Lineage Pathway 66
11.54 CD34 FLT3 KIT
9
C-MYB transcription factor network 1
11.39 ANPEP CD34 CEBPA CREBBP GSTM1 KIT
10
B Cell Development Pathways 66
11.36 CD34 FLT3 KIT
11
Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex 1
10.92 CREBBP ETV6 FLT3
12
Benzene metabolism 1
10.26 GSTM1 MPO
Sources

GO Terms for Acute Leukemia

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Biological processes related to Acute Leukemia according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 9.92 ANPEP ETV6 FLT3 JAK2 STMN1
2 positive regulation of transcription, DNA-templated GO:0045893 9.85 CEBPA CREBBP KMT2A MLLT3 RUNX1 WT1
3 positive regulation of DNA-binding transcription factor activity GO:0051091 9.72 CSF3 JAK2 KIT
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.65 FLT3 JAK2 KIT
5 cytokine-mediated signaling pathway GO:0019221 9.65 CEBPA CSF3 FLT3 JAK2 KIT
6 embryonic hemopoiesis GO:0035162 9.54 KIT KMT2A
7 regulation of myeloid cell differentiation GO:0045637 9.51 CREBBP RUNX1
8 transcription by RNA polymerase II GO:0006366 9.5 CEBPA KMT2A MLLT3
9 granulocyte differentiation GO:0030851 9.49 CEBPA CSF3
10 hemopoiesis GO:0030097 9.46 CD34 FLT3 KIT RUNX1
11 myeloid progenitor cell differentiation GO:0002318 9.4 FLT3 KIT
12 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.26 CSF3 FLT3 JAK2 KIT
13 hematopoietic stem cell proliferation GO:0071425 8.8 CD34 ETV6 RUNX1
14 regulation of transcription, DNA-templated GO:0006355 10.03 AFF1 CEBPA CREBBP ETV6 KMT2A MLLT3
15 positive regulation of transcription by RNA polymerase II GO:0045944 10 CEBPA CREBBP CSF3 ETV6 KMT2A RUNX1

Molecular functions related to Acute Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.43 FLT3 JAK2 KIT
2 transcription regulatory region DNA binding GO:0044212 9.26 CEBPA KMT2A RUNX1 WT1
3 lysine-acetylated histone binding GO:0070577 9.16 KMT2A MLLT3
4 DNA-binding transcription factor activity GO:0003700 9.1 AFF1 CEBPA ETV6 KMT2A RUNX1 WT1
Sources

Sources for Acute Leukemia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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