Acute Leukemia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ACT073 MIFTS: 62	Acute Leukemia Categories: Blood diseases, Bone diseases, Cancer diseases, Immune diseases
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Aliases & Classifications for Acute Leukemia

MalaCards integrated aliases for Acute Leukemia:

Name: Acute Leukemia ³⁹ ¹² ³⁰ ⁵⁶ ¹⁵ ¹⁷ ⁷⁴

Acute Undifferentiated Leukemia ⁷⁴

Undifferentiated Leukemia ⁷⁴

Stem Cell Leukaemia ¹²

Stem Cell Leukemia ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Blood diseases Immune diseases Bone diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Neoplasms

Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue

Leukaemia of unspecified cell type

Acute leukaemia of unspecified cell type

External Ids:

Disease Ontology ¹² DOID:12603

ICD9CM ³⁶ 208.0

NCIt ⁵¹ C9300

SNOMED-CT ⁶⁹ 24072005 91855006

ICD10 ³⁴ C95.0 C95.00

EFO ¹⁷ EFO_1000068

UMLS ⁷⁴ C0085669 C0280141 C1378511

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Summaries for Acute Leukemia

Disease Ontology : ¹² A leukemia that occurs when a hematopoietic stem cell undergoes malignant transformation into a primitive, undifferentiated cell with abnormal longevity. These lymphocytes (acute lymphocytic leukemia [ALL]) or myeloid cells (acute myelocytic leukemia [AML]) proliferate abnormally, replacing normal marrow tissue and hematopoietic cells and inducing anemia, thrombocytopenia, and granulocytopenia.

MalaCards based summary : Acute Leukemia, also known as acute undifferentiated leukemia, is related to megakaryocytic leukemia and childhood leukemia. An important gene associated with Acute Leukemia is BAALC (BAALC Binder Of MAP3K1 And KLF4), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Arsenic trioxide and Amphotericin B have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow, and related phenotypes are no effect and Reduced mammosphere formation

Wikipedia : ⁷⁷ Acute leukemia or acute leukaemia is a family of serious medical conditions relating to an original... more...

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Related Diseases for Acute Leukemia

Diseases in the Leukemia family:

Acute Leukemia	Chronic Leukemia
Subacute Leukemia

Diseases related to Acute Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 454)

#	Related Disease	Score	Top Affiliating Genes
1	megakaryocytic leukemia	32.5	JAK2 MPO RUNX1
2	childhood leukemia	32.5	ETV6 KMT2A MLLT3 MTHFR RUNX1
3	acute lymphocytic leukemia	32.4	CSF3 ETV6 GSTM1 MTHFR RUNX1
4	lymphoblastic lymphoma	32.3	DNTT KMT2A MPO
5	leukemia, acute lymphoblastic	32.3	AFF1 ANPEP DNTT ETV6 FLT3 KMT2A
6	leukemia	32.2	BAALC CEBPA CREBBP ETV6 FLT3 JAK2
7	acute promyelocytic leukemia	32.0	ANPEP CD34 CEBPA CSF3 FLT3 MPO
8	lymphocytic leukemia	30.9	DNTT ETV6 KMT2A RUNX1
9	leukemia, acute myeloid	30.7	AFF1 ANPEP BAALC CD34 CEBPA CSF3
10	myeloid leukemia	30.5	CEBPA CREBBP ETV6 FLT3 JAK2 KIT
11	lymphoid leukemia	30.3	ETV6 FLT3 JAK2 KMT2A
12	aplastic anemia	30.3	CD34 CSF3 FLT3 GSTM1
13	chronic myelomonocytic leukemia	30.2	ETV6 FLT3 JAK2 KIT RUNX1
14	myelodysplastic syndrome	30.2	ANPEP CD34 CEBPA CREBBP CSF3 DNTT
15	myeloma, multiple	30.1	CD34 CSF3 JAK2 KIT
16	8p11 myeloproliferative syndrome	30.0	FLT3 KIT RUNX1
17	chronic eosinophilic leukemia	29.9	FLT3 KIT WT1
18	cytogenetically normal acute myeloid leukemia	29.8	CEBPA FLT3 KMT2A WT1
19	acute erythroid leukemia	29.8	CEBPA JAK2
20	acute lymphoblastic leukemia, childhood	29.8	ETV6 GSTM1 MTHFR RUNX1
21	myeloid sarcoma	29.7	ANPEP DNTT FLT3 KIT KMT2A MPO
22	myelofibrosis	29.7	CD34 CSF3 FLT3 JAK2 KIT
23	lymphoma, non-hodgkin, familial	29.7	CD34 CSF3 DNTT JAK2
24	gastrointestinal stromal tumor	29.4	CD34 FLT3 KIT MTHFR
25	leukemia, chronic myeloid	28.9	CD34 CSF3 DNTT ETV6 FLT3 JAK2
26	acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	28.7	CREBBP DNTT ETV6 FLT3 KIT KMT2A
27	precursor t-cell acute lymphoblastic leukemia	28.7	ANPEP CD34 DNTT ETV6 FLT3 KMT2A
28	bone marrow cancer	28.5	ANPEP CD34 CSF3 ETV6 FLT3 JAK2
29	acute leukemia of ambiguous lineage	12.4
30	chromosome 8p11 myeloproliferative syndrome	11.9
31	invasive aspergillosis	11.4
32	chronic leukemia	11.4
33	myeloproliferative neoplasm	11.4
34	myelodysplastic myeloproliferative cancer	11.1
35	severe congenital neutropenia	11.1
36	mthfr gene variant	11.1
37	hematopoietic stem cell transplantation	10.6
38	lymphoma	10.5
39	acute myeloid leukemia with t(9;11)(p22;q23)	10.5	KMT2A MLLT3
40	subacute myeloid leukemia	10.5	FLT3 JAK2
41	ring chromosome 21	10.5	ETV6 KMT2A
42	chromophobe renal cell carcinoma	10.5
43	renal oncocytoma	10.5
44	acute myeloblastic leukemia with maturation	10.5	FLT3 KIT
45	testicular gonadoblastoma	10.5	KIT WT1
46	b-cell childhood acute lymphoblastic leukemia	10.4	ETV6 RUNX1
47	acute myeloid leukemia with minimal differentiation	10.4	FLT3 MPO
48	nondisjunction	10.4	KIT MTHFR
49	blood coagulation disease	10.4	CSF3 JAK2 MTHFR
50	congenital mesoblastic nephroma	10.4	ETV6 KIT WT1

Comorbidity relations with Acute Leukemia via Phenotypic Disease Network (PDN):

Deficiency Anemia

Neutropenia

Graphical network of the top 20 diseases related to Acute Leukemia:

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Symptoms & Phenotypes for Acute Leukemia

GenomeRNAi Phenotypes related to Acute Leukemia according to GeneCards Suite gene sharing:

²⁷

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.26	AFF1 ANPEP BAALC CD34 CEBPA CREBBP
2	Reduced mammosphere formation	GR00396-S	9.17	CD34 CEBPA CSF3 ETV6 GSTM1 KMT2A

MGI Mouse Phenotypes related to Acute Leukemia:

⁴⁷ (show all 14)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	10.38	AFF1 ANPEP CD34 CEBPA CREBBP CSF3
2	immune system	MP:0005387	10.34	AFF1 ANPEP CD34 CEBPA CREBBP CSF3
3	homeostasis/metabolism	MP:0005376	10.3	CD34 CEBPA CREBBP DNTT ETV6 FLT3
4	growth/size/body region	MP:0005378	10.27	AFF1 CEBPA CREBBP ETV6 FLT3 JAK2
5	cardiovascular system	MP:0005385	10.24	ANPEP CEBPA CREBBP ETV6 KIT KMT2A
6	endocrine/exocrine gland	MP:0005379	10.21	AFF1 ANPEP CEBPA CREBBP ETV6 FLT3
7	integument	MP:0010771	10.14	ANPEP CD34 CEBPA CREBBP CSF3 ETV6
8	embryo	MP:0005380	10.13	CREBBP ETV6 JAK2 KIT KMT2A MLLT3
9	mortality/aging	MP:0010768	10.13	AFF1 CEBPA CREBBP ETV6 FLT3 JAK2
10	liver/biliary system	MP:0005370	9.97	CEBPA CREBBP JAK2 KIT KMT2A MTHFR
11	neoplasm	MP:0002006	9.9	CD34 CEBPA CREBBP ETV6 FLT3 JAK2
12	muscle	MP:0005369	9.8	CEBPA CREBBP KIT KMT2A MPO STMN1
13	no phenotypic analysis	MP:0003012	9.65	AFF1 CEBPA ETV6 FLT3 KIT KMT2A
14	normal	MP:0002873	9.32	CEBPA CREBBP DNTT ETV6 JAK2 KIT

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Drugs & Therapeutics for Acute Leukemia

Drugs for Acute Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 463)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Arsenic trioxide

Approved, Investigational

Phase 4,Phase 2,Phase 1,Not Applicable

1327-53-3

518740

Amphotericin B

Approved, Investigational

Phase 4,Phase 3,Phase 2

1397-89-3

5280965 14956

Miconazole

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

22916-47-8

4189

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1

1177-87-3

Dexamethasone

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1

50-02-2

5743

Vincristine

Approved, Investigational

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

2068-78-2, 57-22-7

5978

Fludarabine

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

75607-67-9, 21679-14-1

30751

Lenograstim

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

135968-09-1

Sargramostim

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

123774-72-1, 83869-56-1

Cytarabine

Approved, Experimental, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

147-94-4, 65-46-3

6253

Busulfan

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

55-98-1

2478

Vidarabine

Approved, Investigational

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

24356-66-9

21704 32326

Cyclophosphamide

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

50-18-0, 6055-19-2

2907

Mycophenolic acid

Approved

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

24280-93-1

446541

Posaconazole

Approved, Investigational, Vet_approved

Phase 4,Phase 2

171228-49-2

147912

Micafungin

Approved, Investigational

Phase 4,Phase 2

235114-32-6

477468 3081921

Antiparasitic Agents

Phase 4,Phase 3,Phase 2,Phase 1

Hormone Antagonists

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Antifungal Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Cytochrome P-450 CYP2C9 Inhibitors

Phase 4,Phase 3,Phase 2,Not Applicable

Antiprotozoal Agents

Phase 4,Phase 3,Phase 2,Phase 1

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Cytochrome P-450 Enzyme Inhibitors

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Liposomal amphotericin B

Phase 4,Phase 3,Phase 2

Anti-Bacterial Agents

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

Cytochrome P-450 CYP3A Inhibitors

Phase 4,Phase 3,Phase 2,Not Applicable

Hormones

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Anti-Infective Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Steroid Synthesis Inhibitors

Phase 4,Phase 3,Phase 2,Not Applicable

Antineoplastic Agents, Hormonal

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Antimitotic Agents

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

Antiemetics

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Antineoplastic Agents, Phytogenic

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Gastrointestinal Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

glucocorticoids

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

HIV Protease Inhibitors

Phase 4,Phase 3,Phase 2,Phase 1

Anti-Inflammatory Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Peripheral Nervous System Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

protease inhibitors

Phase 4,Phase 3,Phase 2,Phase 1

Autonomic Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

BB 1101

Phase 4,Phase 3,Phase 2,Phase 1

Antimetabolites

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Immunosuppressive Agents

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Adjuvants, Immunologic

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Antineoplastic Agents, Alkylating

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Antiviral Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Thymoglobulin

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Alkylating Agents

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Immunologic Factors

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

Antimetabolites, Antineoplastic

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 635)

#	Name	Status	NCT ID	Phase	Drugs
1	Treatment Protocol for Relapsed Acute Promyelocytic Leukemia (APL) With Arsenic	Unknown status	NCT00196768	Phase 4	Arsenic trioxide;Trisenox
2	PROPHYSOME: Pilot Study on Safety of a Weekly Administration of 10mg/kg of AmBisome® in Antifungal Prophylaxis Treatment of Allogeneic Stem-cell Transplantation and Acute Leukaemia	Completed	NCT00362544	Phase 4	Ambisome
3	Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome	Completed	NCT01200355	Phase 4	micafungin;posaconazole
4	Treatment of Relapsed Promyelocytic Leukemia With Arsenic Trioxide (ATO)	Completed	NCT00504764	Phase 4	Arsenic Trioxide;ATRA
5	Pulses of Vincristine and Dexamethasone in BFM Protocols for Children With Acute Lymphoblastic Leukemia	Completed	NCT00411541	Phase 4	vincristine;dexamethasone
6	Study of Busulfan and FLAG Conditioning Regimen for Allogeneic Peripheral Blood Stem Cell Transplantation	Not yet recruiting	NCT02784561	Phase 4	Busulfan (Zhejiang Otsuka Pharmaceutical Co. Ltd);Cytarabine(Actavis Italy S.p.A);Fludarabine (Bayer);granulocyte colony-stimulating factor (KirinKunpeng);rabbit ATG（Sanofi/Genzyme）
7	Combination of Thrombopoietin Mimetic and Immunosuppressive Therapy in Aplastic Anaemia	Not yet recruiting	NCT03896971	Phase 4	Combination of thrombopoietin mimetic and cyclosporin A
8	A Optimal Anti-Thymoglobuline (ATG) Dose Decrease cGVHD But Not Increase Leukemia Relapse for Haplo-HSCT	Not yet recruiting	NCT03190733	Phase 4	ATG
9	Busulfan and Cyclophosphamide Instead of Total Boby Irradiation (TBI) and Cyclophosphamide for Hematological Malignancies Hematocrit (HCT)	Not yet recruiting	NCT01339988	Phase 4	Busulfan/Cyclophosphamide
10	ProphyALL - Study on the Safety of Liposomal Amphotericin B to Prevent Antifungal Infections in Elderly Patients With Acute Lymphoblastic Leukemia	Terminated	NCT00386997	Phase 4	liposomal amphotericin B (AmBisome®)
11	Antifungal Prophylaxis in Pediatric Acute Leukemia	Unknown status	NCT00624143	Phase 3	ORAL VORICONAZOLE and IV Amphotericin B
12	A Study Comparing Single Versus Double Umbilical Cord Blood Transplantation in the Young With Acute Leukemia Remission	Unknown status	NCT01067300	Phase 3
13	Megakaryocytic Progenitor Cells for Prophylaxis and Treatment of Thrombocytopenia	Unknown status	NCT02241031	Phase 2, Phase 3	thrombopoietin (TPO) and interleukin-11
14	MRD-directed Donor Lymphocyte Infusion for Reduce of Relapse After Allo-HSCT	Unknown status	NCT02673008	Phase 2, Phase 3
15	Decitabine Augments for Post Allogeneic Stem Cell Transplantation in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndrome	Unknown status	NCT01809392	Phase 2, Phase 3	decitabine
16	Evaluation of Plasmatic Levels of Busulfan in Patients Undergoing Hematopoietic Stem Cell Transplantation	Unknown status	NCT01800643	Phase 2, Phase 3
17	Thymoglobulin in Unrelated Hematopoietic Progenitor Cell Transplantation	Unknown status	NCT01217723	Phase 3
18	Pegylated Liposomal Doxorubicin Versus Daunorubicin to Treat Acute Lymphoblastic Leukemia:	Unknown status	NCT02070523	Phase 3	VDCLD regimen
19	Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain	Unknown status	NCT01316744	Phase 3	ketamine hydrochloride
20	Levofloxacin Compared With Cefepime in Treating Cancer Patients With Fever and Neutropenia	Unknown status	NCT00020865	Phase 3	cefepime hydrochloride;levofloxacin
21	Combination Chemotherapy Plus Steroid Therapy in Treating Children With Acute Lymphoblastic Leukemia or Lymphoblastic Non-Hodgkin's Lymphoma	Unknown status	NCT00003728	Phase 3	asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;leucovorin calcium;mercaptopurine;methotrexate;methylprednisolone;mitoxantrone hydrochloride;prednisolone;therapeutic hydrocortisone;thioguanine;vincristine sulfate;vindesine
22	Clove In The Treatment Of Relapsed Or Resistant Acute Leukemia In Children	Completed	NCT01385891	Phase 2, Phase 3	Clofarabine VP 16 ciclophospahamide
23	Levofloxacin in Preventing Infection in Young Patients With Acute Leukemia Receiving Chemotherapy or Undergoing Stem Cell Transplantation	Completed	NCT01371656	Phase 3	levofloxacin
24	Chronic Graft-versus-host Disease (cGvHD) Prophylaxis With or Without ATG Prior to Stem Cell Transplantation (SCT) From HLA-identical Siblings in Patients With Acute Leukemia	Completed	NCT00678275	Phase 3	ATG FRESENIUS (Anti-Lymphocyte-Globulin);ATG FRESENIUS (Anti-Lymphocyte-Globulin)
25	Bone Marrow Transplantation in Treating Patients With Acute Leukemia in First or Second Remission	Completed	NCT00002534	Phase 3	cyclophosphamide;cytarabine;methylprednisolone;thiotepa
26	Peripheral Blood (PB) Versus Bone Marrow (BM) in Allogeneic Stem Cell Transplantation	Completed	NCT01020175	Phase 3
27	Busulfan Plus Cyclophosphamide vs Fludarabine as a Conditioning Regimen	Completed	NCT00774280	Phase 3	BuCy vs BuFlu
28	Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Acute Lymphoblastic Leukemia	Completed	NCT00002700	Phase 3	asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;mitoxantrone hydrochloride;prednisolone;prednisone;therapeutic hydrocortisone;vincristine sulfate
29	Treatment of Acute Myeloid Leukemia (AML) in Adults 50 to 70 Years, Study of Two Anthracyclines and the Interest of Maintenance Treatment With Interleukin 2	Completed	NCT00931138	Phase 3	chemotherapy (Aracytine + Daunorubicin);chemotherapy (Aracytine + Daunorubicin);chemotherapy (Aracytine + Daunorubicin)
30	A Randomized Study of Gemtuzumab Ozogamicin (GO) With Daunorubicine and Cytarabine in Untreated Acute Myeloid Leukemia (AML) Aged of 50-70 Years Old	Completed	NCT00927498	Phase 3	conventional chemotherapy (AraC + Daunorubicin),;Mylotarg associated with conventional chemotherapy (AraC + Daunorubicin),
31	Effect of Priming During Induction and Consolidations in Younger Acute Myeloid Leukemia (AML)	Completed	NCT00880243	Phase 3	GM-CSF
32	A Multicentre Randomised Controlled Trial Comparing Two Strategies for the Diagnosis of Invasive Aspergillosis in High-risk Haematology Patients	Completed	NCT00163722	Phase 3
33	Tipifarnib Versus Best Supportive Care in the Treatment of Newly Diagnosed Acute Myeloid Leukemia (AML)	Completed	NCT00093990	Phase 3	Tipifarnib;Zarnestra; R115777
34	Timed-Sequential Induction in CBF-AML	Completed	NCT00428558	Phase 3	Chemotherapy (DAUNORUBICINE-CYTARABINE);Chemotherapy (DAUNORUBICINE-CYTARABINE)
35	Efficacy/Safety of Frontline Alemtuzumab (Campath, MabCampath) vs Chlorambucil in Patients With Progressive B-Cell Lymphocytic Leukemia	Completed	NCT00046683	Phase 3	alemtuzumab
36	Prevention of Left Ventricular Dysfunction During Chemotherapy	Completed	NCT01110824	Phase 3	Enalapril and carvedilol
37	Combination Chemotherapy With or Without Lestaurtinib in Treating Younger Patients With Newly Diagnosed Acute Lymphoblastic Leukemia	Completed	NCT00557193	Phase 3	Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin Hydrochloride;Dexamethasone;Etoposide;Lestaurtinib;Leucovorin Calcium;Mercaptopurine;Methotrexate;Methylprednisolone;Pegaspargase;Prednisone;Therapeutic Hydrocortisone;Vincristine Sulfate
38	Personalized Information or Basic Information in Helping Patients Make Decisions About Participating in a Clinical Trial	Completed	NCT00750009	Phase 3
39	American Ginseng in Treating Patients With Fatigue Caused by Cancer	Completed	NCT00719563	Phase 3	American ginseng
40	Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain	Completed	NCT00666211	Phase 3
41	Darbepoetin Alfa With or Without Iron in Treating Anemia Caused By Chemotherapy in Patients With Cancer	Completed	NCT00661999	Phase 3	sodium ferric gluconate complex in sucrose
42	Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain	Completed	NCT00538850	Phase 3	Fentanyl sublingual spray;Placebo
43	Dalteparin to Prevent Complications in Cancer Patients Receiving Chemotherapy Through a Catheter	Completed	NCT00006083	Phase 3	Fragmin
44	Bone Marrow Transplantation in Treating Patients With Leukemia, Myelodysplasia, or Lymphoblastic Lymphoma	Completed	NCT00003187	Phase 2, Phase 3	cyclophosphamide;cyclosporine;cytarabine;methotrexate;methylprednisolone
45	Ondansetron in Treating Patients With Advanced Cancer and Chronic Nausea and Vomiting Not Caused by Cancer Treatment	Completed	NCT00006348	Phase 3	ondansetron
46	Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment	Completed	NCT00008359	Phase 3	caspofungin acetate;liposomal amphotericin B
47	Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients	Completed	NCT00003938	Phase 3	liposomal amphotericin B
48	Treatment for Chronic Pain in Patients With Advanced Cancer	Completed	NCT00003687	Phase 3	dextromethorphan hydrobromide;morphine sulfate
49	Decitabine+BUCY vs BUCY Conditioning Regimen for MLL+ Acute Leukemia Undergoing Allo-HSCT	Recruiting	NCT03596892	Phase 2, Phase 3	Decitabine;Busulfan (BU);Cyclophosphamide (CY)
50	Decitabine Plus mBU/CY Preconditioning for Relapse/Refractory Acute Leukemia	Recruiting	NCT03799224	Phase 2, Phase 3	Decitabine;mBU/CY and ATG;mBU/CY

Search NIH Clinical Center for Acute Leukemia

Cell-based therapeutics:

Data from LifeMap, the Embryonic Development and Stem Cells Database

Read about Acute Leukemia cell therapies at LifeMap Discovery.

Stem-cell-based therapeutic approaches for Acute Leukemia:

Promostem, mesenchymal stem cells for treatment of graft-versus-host disease

Sources

Genetic Tests for Acute Leukemia

Genetic tests related to Acute Leukemia:

#	Genetic test	Affiliating Genes
1	Acute Leukemia ³⁰

Sources

Anatomical Context for Acute Leukemia

MalaCards organs/tissues related to Acute Leukemia:

⁴²

Myeloid, Bone, Bone Marrow, T Cells, B Cells, Liver, Nk Cells

Sources

Publications for Acute Leukemia

Articles related to Acute Leukemia:

(show top 50) (show all 3781)

#	Title	Authors	Year
1	Clinically useful flow cytometry approach to identify immunophenotype in acute leukemia. ( 30614357 )	Ouyang G...Duan S	2019
2	Early Deaths in Pediatric Acute Leukemia: A Major Challenge in Developing Countries. ( 30615014 )	Hafez HA...Shalaby LM	2019
3	Therapeutic granulocyte transfusions: neutropenic patients with acute leukemia continue to need them - why are definitive evidence-based practice guidelines elusive? ( 30615809 )	Strauss RG	2019
4	Increased Health Care Utilization and Costs during Allogeneic Hematopoietic Cell Transplantation for Acute Leukemia and Myelodysplastic Syndromes in Adolescents and Young Adults Compared with Children: A Multicenter Study. ( 30625391 )	Rangarajan HG...O'Brien SH	2019
5	Challenges in Clinical Metaproteomics Highlighted by the Analysis of Acute Leukemia Patients with Gut Colonization by Multidrug-Resistant Enterobacteriaceae. ( 30626002 )	Rechenberger J...Kuster B	2019
6	Effect of laminar air flow and building construction on aspergillosis in acute leukemia patients: a retrospective cohort study. ( 30626352 )	Iwasaki M...Takaori-Kondo A	2019
7	Impacts of thymoglobulin in patients with acute leukemia in remission undergoing allogeneic HSCT from different donors. ( 30626574 )	Wakamatsu M...GVHD Working Group of the Japan Society for Hematopoietic Cell Transplantation	2019
8	Small molecule inhibitor of c-Myc 10058-F4 inhibits proliferation and induces apoptosis in acute leukemia cells, irrespective of PTEN status. ( 30639430 )	Bashash D...Momeny M	2019
9	Bloodstream infection (BSI) due to Vancomycin-Resistant Enterococcus (VRE) is associated with increased mortality after hematopoietic cell transplantation for acute leukemia and myelodysplastic syndrome: A multicenter, retrospective cohort study. ( 30649224 )	Papanicolaou GA...CIBMTR? Infection and Immune Reconstitution Working Committee	2019
10	Memantine potentiates cytarabine-induced cell death of acute leukemia correlating with inhibition of Kv1.3 potassium channels, AKT and ERK1/2 signaling. ( 30651113 )	Lowinus T...Bommhardt U	2019
11	Resolution of celiac disease, IgA deficiency and platelet refractoriness after allogeneic bone marrow transplantation for acute leukemia. ( 30655374 )	Zandi S...Pendergrast J	2019
12	Mathematical models of amino acid panel for assisting diagnosis of children acute leukemia. ( 30674317 )	Liu Z...Zou L	2019
13	Targeted Polo-like Kinase Inhibition Combined With Aurora Kinase Inhibition in Pediatric Acute Leukemia Cells. ( 30702467 )	Jayanthan A...Narendran A	2019
14	Very rare lineage switch from acute myeloid leukemia to mixed phenotype acute leukemia, B/Myeloid, during chemotherapy with no clonal evolution. ( 30707502 )	Nomani L...Rogers HJ	2019
15	Mouse acute leukemia develops independent of self-renewal and differentiation potentials in hematopoietic stem and progenitor cells. ( 30733302 )	Dong F...Ema H	2019
16	Long Non-Coding RNA and Acute Leukemia. ( 30744139 )	Cruz-Miranda GM...Jim?nez-Morales S	2019
17	Analytical performance of automated platelet counts and impact on platelet transfusion guidance in patients with acute leukemia. ( 30761915 )	Tantanate C...Pattanapanyasat K	2019
18	Concomitant use of blinatumomab and donor lymphocyte infusion for mixed-phenotype acute leukemia: a case report with literature review. ( 30786841 )	Durer S...Anwer F	2019
19	'Acute leukemia in congenital methehemoglobinemia - an enigma to explore'. ( 30788079 )	Al-Khafaji JF...Abdalla AO	2019
20	Sorafenib improves survival of FLT3-mutated acute myeloid leukemia in relapse after allogeneic stem cell transplantation: a report of EBMT acute leukemia Working Party. ( 30792203 )	Bazarbachi A...Acute Leukemia Working Party (ALWP) of the European Society for Blood and Marrow Transplantation (EB	2019
21	Doripenem versus meropenem as first-line empiric therapy of febrile neutropenia in patients with acute leukemia: a prospective, randomized study. ( 30824955 )	Oyake T...Ishida Y	2019
22	Audit of Quality and Quantity of Nucleic Acid Yield from Pediatric Acute Leukemia Cases Following a Bio-banking Initiative. ( 30828152 )	Kumar A...Singh A	2019
23	Mixed Phenotype Acute Leukemia, B/Myeloid with t(9;22): Diagnostic and Therapeutic Challenges. ( 30828170 )	Awasthi NP...Agrawal N	2019
24	Psychosocial Experiences of Young Adults Diagnosed With Acute Leukemia During Hospitalization for Induction Chemotherapy Treatment. ( 30829935 )	Albrecht TA...Rosenzweig M	2019
25	Correction to: Minimal residual disease- and graft-vs.-host disease-guided multiple consolidation chemotherapy and donor lymphocyte infusion prevent second acute leukemia relapse after allotransplant. ( 30836977 )	Yan CH...Huang XJ	2019
26	Lipodystrophy-like features after total body irradiation among survivors of childhood acute leukemia. ( 30844749 )	Visentin S...Beliard S	2019
27	Spectrum and Immunophenotypic Profile of Acute Leukemia: A Tertiary Center Flow Cytometry Experience. ( 30858955 )	Gupta N...Mishra D	2019
28	ATP-Binding Cassette transporters' gene expression in pediatric patients with acute leukemia; a comprehensive analysis of published reports through PubMed search engine. ( 30860475 )	Mehrvar N...Movafagh A	2019
29	Acute leukemia in a patient with 15q overgrowth syndrome. ( 30861314 )	Bodle EE...Manning MA	2019
30	Identification of chromosomal abnormalities and genomic features in near-triploidy/tetraploidy-acute leukemia by fluorescence in situ hybridization. ( 30863166 )	Yang R...Li Q	2019
31	Checkpoint inhibition of PD-L1 and CTLA-4 in a child with refractory acute leukemia. ( 30863527 )	Broglie L...Burke MJ	2019
32	High rates of ovarian function preservation after hematopoietic cell transplantation with melphalan-based reduced intensity conditioning for pediatric acute leukemia: an analysis from the Japan Association of Childhood Leukemia Study (JACLS). ( 30864117 )	Fujino H...Horibe K	2019
33	Mixed-phenotype acute leukemia with t(4;11)(q21;q23) KMT2A-AFF1-rearranged. ( 30872272 )	Liu H	2019
34	Efficacy of levofloxacin as an antibacterial prophylaxis for acute leukemia patients receiving intensive chemotherapy: a systematic review and meta-analysis. ( 30880638 )	Owattanapanich W...Chayakulkeeree M	2019
35	Ophthalmic Manifestations of Acute Leukemia. ( 30891378 )	Hafeez MU...Butt NH	2019
36	Association between NAT2 polymorphisms and acute leukemia risk: A meta-analysis. ( 30896661 )	Zhu X...Li X	2019
37	Staging of acute leukemia based on central nervous system involvement alone: Is it appropriate? ( 30900807 )	Totadri S...Bansal D	2019
38	Nasal embryonal rhabdomyosarcoma with bone marrow metastasis simulating acute leukemia: A case report and review of the literature. ( 30902383 )	Nazco Deroy ?...Raya S?nchez JM	2019
39	Treatment of venous thromboembolism in acute leukemia: A systematic review. ( 30921533 )	Ahrari A...Lazo-Langner A	2019
40	Xiao W, Bharadwaj M, Levine M, et al. PHF6 and DNMT3A mutations are enriched in distinct subgroups of mixed phenotype acute leukemia with T-lineage differentiation. Blood Adv. 2018;2(23):3526-3539. ( 30926597 )		2019
41	Can allogeneic hematopoietic cell transplant cure therapy-related acute leukemia? ( 30927969 )	Madanat YF...Gerds AT	2019
42	A novel thiosemicarbazone as a promising effective and selective compound for acute leukemia. ( 30932944 )	Perondi DM...Santos-Silva MC	2019
43	Alternative splicing of the tumor suppressor ASPP2 results in a stress-inducible, oncogenic isoform prevalent in acute leukemia. ( 30952616 )	Schittenhelm MM...Kampa-Schittenhelm KM	2019
44	Corrigendum to 'Interferon-α is effective for treatment of minimal residual disease in patients with acute leukemia after allogeneic hematopoietic stem cell transplantation: results of a registry study' [Biology of Blood and Marrow Transplantation 23/8 (2017) 1303-1310]. ( 30953638 )	Mo XD...Huang XJ	2019
45	Corrigendum to 'Interferon α: A potentially effective treatment for minimal residual disease in acute leukemia/myelodysplastic syndrome after allogeneic hematopoietic stem cell transplantation' [Biology of Blood and Marrow Transplantation 21/11 (2015) 1939-1947]. ( 30954498 )	Mo XD...Huang XJ	2019
46	Biphenotypic acute leukemia or acute leukemia of ambiguous lineage in childhood: clinical characteristics and outcome. ( 30956966 )	Lee HG...Kook H	2019
47	18F-FDG PET/CT for extramedullary relapse of acute leukemia of ambiguous lineage. ( 30967343 )	de Bonilla Dami? ?...Borrego Dorado I	2019
48	Cytomegalovirus Retinitis in Children and Adolescents with Acute Leukemia following allogeneic Hematopoietic Stem Cell Transplantation. ( 30972869 )	Z?llner SK...Groll AH	2019
49	Umbilical cord blood versus unrelated donor transplantation in adults with primary refractory or relapsed acute myeloid leukemia: a report from Eurocord, the Acute Leukemia Working Party and the Cord Blood Committee of the Cellular Therapy and Immunobiology Working Party of the EBMT. ( 30979868 )	Baron F...Nagler A	2019
50	Dysbiosis patterns during re-induction/salvage versus induction chemotherapy for acute leukemia. ( 30988420 )	Rashidi A...Staley C	2019

Sources

Genes for Acute Leukemia

Genes related to Acute Leukemia (0 elite genes):

(show all 30)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	BAALC	BAALC Binder Of MAP3K1 And KLF4	Protein Coding	50.62	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Gene name Proteins Transcripts (show sections)
2	MTHFR	Methylenetetrahydrofolate Reductase	Protein Coding	44.31	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications Summaries Proteins (show sections)	17071478 17071465 11340609 (more) 11274424 20367562 12827651 17339179 12672676
3	FLT3	Fms Related Tyrosine Kinase 3	Protein Coding	43.06	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Disorders Publications (show sections)	17584026 15778081 17387224 (more) 18925699 20302766 20515557 12357354 15996732 17233551 19052976 8677746 20072157 1384791 10803532 16757428 12796379 16800917 16321848 16185475 10373018 19075657 16557239 12836614 15374944 16025155 15618475 8562934 20425341 17708815 17943971 8637232 20370649 15950498 18977066 15150124 16418499 17584149
4	WT1	WT1 Transcription Factor	Protein Coding	41.42	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications Functions (show sections)	7949179 10100271 16129044 (more) 7596170 17803653 19212333 19662212 10480287 18161786 12215007 12835718 14510942 16876863 10422290 10921096 12357365 15363132 9222290 15730716 9484784 19811333 7643450 15534117 8639907 8630376 17690705 15907324 12080641 10529509 9531607 16341043 16471322 12971856 12200377 11807803 8943879 20129107 15339675 12411055 12215009 10607714 9609529 9052749 15920488 11852808 11296223 20013787 19404640 18443273 12837194 12613515 11602325 10378895 15223632 11014901 12750711 9001425 10674900 20435628 10360378
5	RUNX1	RUNX Family Transcription Factor 1	Protein Coding	41.21	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Disorders Publications (show sections)	17920312 16575471 20306249 (more) 17532767 17968322 8613429 10482986 17011991 19151769 10684580 20080465 20007546 10717473 12771199 15156187 15950498 16247465 20181616 8395311 8049440 12604126 15988004 16803898 11566347 12555067 11328817 10594034 19357396 18224409 7780155 9031072 10825008 11023523
6	ETV6	ETS Variant 6	Protein Coding	39.6	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Disorders Publications (show sections)	11343784 8808688 12823350 (more) 7780150 9529134 12555218 9060558 11439334
7	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	39.13	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Disorders Publications (show sections)	9407735 9658721 10229319 (more) 10739002 8605274 12562262 18977066 12836614 20165856 7529077 1371882 18787634 8127154 12194988 18337231
8	JAK2	Janus Kinase 2	Protein Coding	38.66	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Disorders Publications (show sections)	18394555 18618714 15805263 (more) 16037387 16557239 18297515 17077140 17068151 18024602 18230964 19489438
9	KMT2A	Lysine Methyltransferase 2A	Protein Coding	36.21	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	8443374 11069023 8824725 (more) 9447829 17284365 9029018 10557043 12472570 7658717 16983345 9230194 11167824 8016145 16383239 7529550 1423625 7885037 15755504 15160920 9010221 8703835 8298125 8378328 15269783 8709635 9247308 20206559 9539779 12957285 19074864 8329709 8616868 9353299 15323147 15322560 12860012 11522623 11510203 11433529 11289128 10583275 9760153 18224408 16433901 15626757 14575001 11527155 11477655 10822761 9844603 9539705 9292512 8558942 7675546 19262598 18474298 17164354 16511515 16843108 16085566 8134107 8282816 8361504 17854664 17726105 16857431 16105754 15464450 12368154 12165445 10679814 10457404 10381524 9592986 10825008 10706136 10374852 8108133 19277575 17942707 16357144 16424875 15815718 12835743 10233389 8616778 8044771 8506328 20139053 19530238 8934551 8640793 7761425 7949133 20080465 17957188 17854671 16158928 14704031
10	CEBPA	CCAAT Enhancer Binding Protein Alpha	Protein Coding	35.95	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Disorders Publications (show sections)	12351377
11	STMN1	Stathmin 1	Protein Coding	35.71	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications Expressions (show sections)	1917919 1401087 8412315 (more) 9324290 7925472 1930203 8125092
12	CREBBP	CREB Binding Protein	Protein Coding	34.01	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications Functions (show sections)	10469454 10706136
13	ANPEP	Alanyl Aminopeptidase, Membrane	Protein Coding	33.46	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	12562262 11241503 8023515 (more) 1493908 10229319 8624374
14	MPO	Myeloperoxidase	Protein Coding	33.24	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	19935430 9725460 8396697 (more) 17479404 8386105 7493141 1666891 9217186 8579056 15624329 9704614 1311196 1333591 7719239 10233410 10986389 12562262 15786701 9140287 2173803 19327122 19298796 8167554 7944272 8035623 8023515 8118606 8220154 7962655 10655992 8624374 9859768 7496347 8291896 8388970 8383541 10889907 8155836 1977771 8853033 12513830 11340609 10359066 9766845 9479874 8659452 8237269 8501986 16298822 16893519 17325954 19605811 19893347 1913454 1331562
15	GSTM1	Glutathione S-Transferase Mu 1	Protein Coding	33.01	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications Functions (show sections)	15862746 17581325 18610829 (more) 16676594 15738600 16493615 12827651
16	MLLT3	MLLT3 Super Elongation Complex Subunit	Protein Coding	32.6	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	15269783
17	AFF1	AF4/FMR2 Family Member 1	Protein Coding	24.65	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	8353274 7698025 11527155 (more) 8378328 1423625 15269783
18	CSF3	Colony Stimulating Factor 3	Protein Coding	23.63	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	8691565 7531394 16858272 (more) 1714757 10942233 9644302 10897214 8637222 11290617 10731945 12752636 9590144 18020493 8624474 9387641 7689127 8588087 10217192 10358698 11869937 8528046 1534271 1709294 19379589 16928319 17563736 16988532 11979751 11486703 8721901 19749982 16777623 11736947 11399510 11105617 11091203 9570678 8656684 19848320 17128529 1697646 17631182 16192477 10657885 7535728 7526087 1372766 1707827 15850828 15461640 14691124 11293503 16295383 14959860 9447843 8608239 7525188 7525857 16080844 8616084 17526862 12393493 14675405 14642178
19	DNTT	DNA Nucleotidylexotransferase	Protein Coding	22.88	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	7723388 1338518 18426728 (more) 7524307 10233410 11131924 19687594 7639197 10655992 7962655 8853033 7496347 1299244 15205205 7654005 8220154 1913454
20	CD34	CD34 Molecule	Protein Coding	22.44	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	19454497 9001869 1712541 (more) 7505888 7526089 10916777 8635059 9658721 11489469
21	PAX5	Paired Box 5	Protein Coding	22.38	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Disorders Publications (show sections)	14676435 15492262
22	MLLT10	MLLT10 Histone Lysine Methyltransferase DOT1L Cofactor	Protein Coding	22.23	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	11423977
23	CD33	CD33 Molecule	Protein Coding	22.19	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	11328295
24	MLLT1	MLLT1 Super Elongation Complex Subunit	Protein Coding	22.13	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	16990786
25	TCF3	Transcription Factor 3	Protein Coding	21.78	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Summaries (show sections)
26	ZNF384	Zinc Finger Protein 384	Protein Coding	21.64	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Summaries (show sections)
27	ABCB1	ATP Binding Cassette Subfamily B Member 1	Protein Coding	21.61	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	8477061 16086884 15512810 (more) 17538395 16614510 10897123 9150348 1380280 9886170 1859877 11877057 7694687 19291917 9742628 10444168 12917035 8731823 12028995 9439046 10920991 8556928 1283551 19862976 9408959 7808005 14526424 8704189 1974821 16138358 15266171 9479874 8535665 7536492 8639853 10971394 10500792 10500786 10500776 10198619 8726405 8656697 8574159 7727868 16109615 12960118 11036680 7895588 7993790 19635183 17301357 11798628 11197207 7622426 8102639 8630412 7528566 7914424 8100604 16799654 15014037 11697502 9868094 1353871 17493328 15854288 9772402 8118816 15363121 8097038 7896208 8075575 9110459 10374270
28	TAL1	TAL BHLH Transcription Factor 1, Erythroid Differentiation Factor	Protein Coding	21.48	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	10049045 1311214 15917481 (more) 8142619 9211539 18495761 16298389 8058326
29	IL3	Interleukin 3	Protein Coding	21.44	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	1766257 8624474 9891868 (more) 2403822 2323674 2090254 7689127 2048564 1635377 8449858 14752873 10721770 2312610 8881103 7515617 8422455 9414269 9067570 8211215 9466481 10496036
30	CD7	CD7 Molecule	Protein Coding	21.12	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	1701841

Sources

Variations for Acute Leukemia

Sources

Expression for Acute Leukemia

Search GEO for disease gene expression data for Acute Leukemia.

Sources

Pathways for Acute Leukemia

Pathways related to Acute Leukemia according to GeneCards Suite gene sharing:

(show all 12)

#	Super pathways	Score	Top Affiliating Genes
1	Endometrial cancer ³⁸ Show member pathways Acute myeloid leukemia ³⁸ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁷ Chronic myeloid leukemia ³⁸ Colorectal cancer ³⁸ Pancreatic cancer ³⁸ Prostate cancer ³⁸ Signal transduction PTEN pathway ²³ Thyroid cancer ³⁸	12.66	CEBPA CREBBP FLT3 KIT MPO RUNX1
2	Pathways in cancer ³⁸	12.59	CEBPA CREBBP FLT3 GSTM1 JAK2 KIT
3	NF-kappaB Signaling ⁴	12.36	CD34 CEBPA JAK2 KIT MPO RUNX1
4	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁶	11.8	ANPEP CD34 CSF3 FLT3 KIT MPO
5	Hematopoietic cell lineage ³⁸	11.62	ANPEP CD34 CSF3 DNTT FLT3 KIT
6	Innate Lymphoid Cell Differentiation Pathways ⁶⁶	11.59	CD34 KIT RUNX1
7	Transcriptional misregulation in cancer ³⁸	11.55	AFF1 CEBPA ETV6 FLT3 KMT2A MLLT3
8	Dendritic Cells Developmental Lineage Pathway ⁶⁶	11.54	CD34 FLT3 KIT
9	C-MYB transcription factor network ¹	11.39	ANPEP CD34 CEBPA CREBBP GSTM1 KIT
10	B Cell Development Pathways ⁶⁶	11.36	CD34 FLT3 KIT
11	Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex ¹	10.92	CREBBP ETV6 FLT3
12	Benzene metabolism ¹	10.26	GSTM1 MPO

Sources

GO Terms for Acute Leukemia

Biological processes related to Acute Leukemia according to GeneCards Suite gene sharing:

(show all 15)

#	Name	GO ID	Score	Top Affiliating Genes
1	cell differentiation	GO:0030154	9.92	ANPEP ETV6 FLT3 JAK2 STMN1
2	positive regulation of transcription, DNA-templated	GO:0045893	9.85	CEBPA CREBBP KMT2A MLLT3 RUNX1 WT1
3	positive regulation of DNA-binding transcription factor activity	GO:0051091	9.72	CSF3 JAK2 KIT
4	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.65	FLT3 JAK2 KIT
5	cytokine-mediated signaling pathway	GO:0019221	9.65	CEBPA CSF3 FLT3 JAK2 KIT
6	embryonic hemopoiesis	GO:0035162	9.54	KIT KMT2A
7	regulation of myeloid cell differentiation	GO:0045637	9.51	CREBBP RUNX1
8	transcription by RNA polymerase II	GO:0006366	9.5	CEBPA KMT2A MLLT3
9	granulocyte differentiation	GO:0030851	9.49	CEBPA CSF3
10	hemopoiesis	GO:0030097	9.46	CD34 FLT3 KIT RUNX1
11	myeloid progenitor cell differentiation	GO:0002318	9.4	FLT3 KIT
12	positive regulation of phosphatidylinositol 3-kinase signaling	GO:0014068	9.26	CSF3 FLT3 JAK2 KIT
13	hematopoietic stem cell proliferation	GO:0071425	8.8	CD34 ETV6 RUNX1
14	regulation of transcription, DNA-templated	GO:0006355	10.03	AFF1 CEBPA CREBBP ETV6 KMT2A MLLT3
15	positive regulation of transcription by RNA polymerase II	GO:0045944	10	CEBPA CREBBP CSF3 ETV6 KMT2A RUNX1

Molecular functions related to Acute Leukemia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	transcription regulatory region DNA binding	GO:0044212	9.26	CEBPA KMT2A RUNX1 WT1
2	lysine-acetylated histone binding	GO:0070577	9.16	KMT2A MLLT3
3	DNA-binding transcription factor activity	GO:0003700	9.1	AFF1 CEBPA ETV6 KMT2A RUNX1 WT1

Sources

Sources for Acute Leukemia

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia