Acute Leukemia

Categories: Cancer diseases, Immune diseases, Blood diseases

Aliases & Classifications for Acute Leukemia

MalaCards integrated aliases for Acute Leukemia:

Name: Acute Leukemia 38 12 29 55 15 73
Acute Undifferentiated Leukemia 73
Undifferentiated Leukemia 73
Stem Cell Leukaemia 12
Stem Cell Leukemia 12


External Ids:

Disease Ontology 12 DOID:12603
ICD10 33 C95.0 C95.00
ICD9CM 35 208.0
NCIt 50 C9298 C9300

Summaries for Acute Leukemia

Disease Ontology : 12 A leukemia that occurs when a hematopoietic stem cell undergoes malignant transformation into a primitive, undifferentiated cell with abnormal longevity. These lymphocytes (acute lymphocytic leukemia [ALL]) or myeloid cells (acute myelocytic leukemia [AML]) proliferate abnormally, replacing normal marrow tissue and hematopoietic cells and inducing anemia, thrombocytopenia, and granulocytopenia.

MalaCards based summary : Acute Leukemia, also known as acute undifferentiated leukemia, is related to chronic eosinophilic leukemia and leukemia, acute lymphoblastic. An important gene associated with Acute Leukemia is BAALC (BAALC, MAP3K1 And KLF4 Binding), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Busulfex and Clolar have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow, and related phenotypes are Reduced mammosphere formation and hematopoietic system

Wikipedia : 76 Acute leukemia or acute leukaemia is a family of serious medical conditions relating to an original... more...

Related Diseases for Acute Leukemia

Diseases in the Leukemia family:

Acute Leukemia Chronic Leukemia
Subacute Leukemia

Diseases related to Acute Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 290)
# Related Disease Score Top Affiliating Genes
1 chronic eosinophilic leukemia 33.0 FLT3 KIT WT1
2 leukemia, acute lymphoblastic 32.8 AFF1 DNTT ETV6 FLT3 KMT2A RUNX1
3 childhood leukemia 32.5 ETV6 KMT2A MLLT1 MTHFR RUNX1
4 acute lymphocytic leukemia 32.3 CSF3 ETV6 GSTM1 MTHFR RUNX1
5 lymphoblastic lymphoma 32.2 DNTT KMT2A MPO
6 leukemia 32.0 BAALC CEBPA ETV6 FLT3 JAK2 KIT
7 acute promyelocytic leukemia 30.6 ANPEP CD34 CEBPA CSF3 FLT3 MPO
8 lymphoid leukemia 30.6 ETV6 FLT3 JAK2 KMT2A
9 lymphoblastic leukemia 30.6 AFF1 ETV6 FLT3 JAK2 MLLT1 RUNX1
10 8p11 myeloproliferative syndrome 30.4 FLT3 KIT RUNX1
11 megakaryocytic leukemia 30.4 JAK2 MPO RUNX1
12 chronic myelomonocytic leukemia 30.3 ETV6 FLT3 JAK2 KIT RUNX1
13 cytogenetically normal acute myeloid leukemia 30.1 CEBPA FLT3 KMT2A WT1
14 myeloid leukemia 29.7 CEBPA CREBBP ETV6 FLT3 JAK2 KIT
15 aplastic anemia 29.0 CD34 CSF3 FLT3 GSTM1
16 myelofibrosis 28.9 CD34 CSF3 FLT3 JAK2 KIT
17 myeloid sarcoma 28.8 ANPEP DNTT FLT3 KIT KMT2A MPO
18 leukemia, acute myeloid 27.9 AFF1 ANPEP BAALC CD34 CEBPA CSF3
19 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 27.8 CREBBP DNTT ETV6 FLT3 KIT KMT2A
20 myelodysplastic syndrome 27.7 ANPEP CD34 CEBPA CREBBP CSF3 DNTT
21 leukemia, chronic myeloid 26.7 CD34 CSF3 DNTT ETV6 FLT3 JAK2
22 acute leukemia of ambiguous lineage 12.2
23 chromosome 8p11 myeloproliferative syndrome 11.7
24 invasive aspergillosis 11.2
25 myeloproliferative neoplasm 11.2
26 ring chromosome 21 11.0 ETV6 KMT2A
27 acute myeloblastic leukemia with maturation 11.0 FLT3 KIT
28 platelet disorder, familial, with associated myeloid malignancy 11.0 ETV6 RUNX1
29 testicular gonadoblastoma 11.0 KIT WT1
30 b-cell childhood acute lymphoblastic leukemia 10.9 ETV6 RUNX1
31 mn1 10.9 ETV6 FLT3 KMT2A
32 myelodysplastic myeloproliferative cancer 10.9
33 chronic leukemia 10.9
34 mthfr gene variant 10.9
35 acute myeloid leukemia with minimal differentiation 10.8 FLT3 MPO
36 nondisjunction 10.8 KIT MTHFR
37 blood coagulation disease 10.8 CSF3 JAK2 MTHFR
38 congenital mesoblastic nephroma 10.8 ETV6 KIT WT1
39 neutrophilia, hereditary 10.8 FLT3 JAK2
40 neonatal leukemia 10.7 AFF1 CREBBP FLT3
41 malignant mesenchymoma 10.7 ETV6 KIT WT1
42 blood platelet disease 10.7 CSF3 JAK2 RUNX1
43 myelophthisic anemia 10.7 ANPEP JAK2
44 acute lymphoblastic leukemia, childhood 10.7 ETV6 GSTM1 MTHFR RUNX1
45 acute basophilic leukemia 10.6 ETV6 MPO
46 arteritic anterior ischemic optic neuropathy 10.6 GSTM1 MPO MTHFR
47 acute myeloid leukemia with t(8;21)(q22;q22) translocation 10.6 CEBPA FLT3 KIT RUNX1
48 severe congenital neutropenia 10.6 CSF3 JAK2 RUNX1
49 leukemia, acute monocytic 10.5 CREBBP KMT2A MPO
50 gallbladder leiomyoma 10.5 CD34 KIT

Comorbidity relations with Acute Leukemia via Phenotypic Disease Network (PDN):

Deficiency Anemia Neutropenia

Graphical network of the top 20 diseases related to Acute Leukemia:

Diseases related to Acute Leukemia

Symptoms & Phenotypes for Acute Leukemia

GenomeRNAi Phenotypes related to Acute Leukemia according to GeneCards Suite gene sharing:

# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 CD34 CEBPA CSF3 ETV6 GSTM1 KMT2A

MGI Mouse Phenotypes related to Acute Leukemia:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.38 FLT3 JAK2 KIT KMT2A MLLT1 MPO
2 immune system MP:0005387 10.34 AFF1 ANPEP CD34 CEBPA CREBBP CSF3
3 homeostasis/metabolism MP:0005376 10.3 CD34 CEBPA CREBBP DNTT ETV6 FLT3
4 cardiovascular system MP:0005385 10.26 ANPEP CEBPA CREBBP DNTT ETV6 KIT
5 growth/size/body region MP:0005378 10.24 AFF1 CEBPA CREBBP ETV6 FLT3 JAK2
6 endocrine/exocrine gland MP:0005379 10.21 AFF1 ANPEP CEBPA CREBBP ETV6 FLT3
7 integument MP:0010771 10.14 ANPEP CD34 CEBPA CREBBP CSF3 ETV6
8 mortality/aging MP:0010768 10.13 MTHFR RUNX1 WT1 AFF1 CEBPA CREBBP
9 liver/biliary system MP:0005370 9.97 CEBPA CREBBP JAK2 KIT KMT2A MLLT1
10 neoplasm MP:0002006 9.9 JAK2 KIT KMT2A MLLT1 RUNX1 WT1
11 muscle MP:0005369 9.8 CEBPA CREBBP KIT KMT2A MPO STMN1
12 no phenotypic analysis MP:0003012 9.61 KMT2A MTHFR RUNX1 WT1 AFF1 CEBPA
13 normal MP:0002873 9.36 DNTT ETV6 JAK2 KIT KMT2A MLLT1

Drugs & Therapeutics for Acute Leukemia

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
Busulfex 18 49 BUSULFAN Orphan Medical February 1999
Clolar 18 49 CLOFARABINE Genzyme December, 2004
Marqibo 18 49 VINCRISTINE SULFATE Talon Therapeutics August 2012

Drugs for Acute Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 360)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Arsenic trioxide Approved, Investigational Phase 4,Phase 2,Not Applicable 1327-53-3 518740
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2 1397-89-3 14956 5280965
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
Busulfan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 55-98-1 2478
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 147-94-4 6253
Fludarabine Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 21679-14-1, 75607-67-9 30751
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 135968-09-1
Vidarabine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 24356-66-9 32326 21704
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-18-0, 6055-19-2 2907
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 128794-94-5 5281078
Mycophenolic acid Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 24280-93-1 446541
Micafungin Approved, Investigational Phase 4,Phase 2 235114-32-6 3081921 477468
Posaconazole Approved, Investigational, Vet_approved Phase 4,Phase 2 171228-49-2 147912
14 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
15 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
16 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
17 Antiparasitic Agents Phase 4,Phase 3,Phase 2
18 Antiprotozoal Agents Phase 4,Phase 3,Phase 2
19 Cytochrome P-450 CYP2C9 Inhibitors Phase 4,Phase 3,Not Applicable
20 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Not Applicable
21 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
22 Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
23 Hormones Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
25 Liposomal amphotericin B Phase 4,Phase 3,Phase 2
26 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
27 Adjuvants, Immunologic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28 Alkylating Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
29 Antimetabolites Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
30 Antimetabolites, Antineoplastic Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
31 Antineoplastic Agents, Alkylating Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
32 Antiviral Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
33 Immunosuppressive Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
34 Antilymphocyte Serum Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
35 Cyclosporins Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
37 Echinocandins Phase 4,Phase 2,Phase 1
Voriconazole Approved, Investigational Phase 3 137234-62-9 71616
Oprelvekin Approved, Investigational Phase 2, Phase 3 145941-26-0
Azacitidine Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 320-67-2 9444
Decitabine Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 2353-33-5 451668
Clofarabine Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 123318-82-1 119182
Etoposide Approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 33419-42-0 36462
Methylprednisolone Approved, Vet_approved Phase 3,Phase 1,Phase 2,Not Applicable 83-43-2 6741
Prednisolone Approved, Vet_approved Phase 3,Phase 1,Phase 2,Not Applicable 50-24-8 5755
Thiotepa Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 52-24-4 5453
Daunorubicin Approved Phase 3,Phase 2,Phase 1,Not Applicable 20830-81-3 30323
Hydrocortisone Approved, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 50-23-7 5754
Levoleucovorin Approved, Investigational Phase 3,Phase 2,Not Applicable 68538-85-2
Methotrexate Approved Phase 3,Phase 2,Phase 1,Not Applicable 1959-05-2, 59-05-2 126941

Interventional clinical trials:

(show top 50) (show all 474)
# Name Status NCT ID Phase Drugs
1 Treatment Protocol for Relapsed Acute Promyelocytic Leukemia (APL) With Arsenic Unknown status NCT00196768 Phase 4 Arsenic trioxide;Trisenox
2 PROPHYSOME: Pilot Study on Safety of a Weekly Administration of 10mg/kg of AmBisome® in Antifungal Prophylaxis Treatment of Allogeneic Stem-cell Transplantation and Acute Leukaemia Completed NCT00362544 Phase 4 Ambisome
3 Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome Completed NCT01200355 Phase 4 micafungin;posaconazole
4 Treatment of Relapsed Promyelocytic Leukemia With Arsenic Trioxide (ATO) Completed NCT00504764 Phase 4 Arsenic Trioxide;ATRA
5 Study of Busulfan and FLAG Conditioning Regimen for Allogeneic Peripheral Blood Stem Cell Transplantation Not yet recruiting NCT02784561 Phase 4 Busulfan (Zhejiang Otsuka Pharmaceutical Co. Ltd);Cytarabine(Actavis Italy S.p.A);Fludarabine (Bayer);granulocyte colony-stimulating factor (KirinKunpeng);rabbit ATG(Sanofi/Genzyme)
6 A Optimal Anti-Thymoglobuline (ATG) Dose Decrease cGVHD But Not Increase Leukemia Relapse for Haplo-HSCT Not yet recruiting NCT03190733 Phase 4 ATG
7 Busulfan and Cyclophosphamide Instead of Total Boby Irradiation (TBI) and Cyclophosphamide for Hematological Malignancies Hematocrit (HCT) Not yet recruiting NCT01339988 Phase 4 Busulfan/Cyclophosphamide
8 ProphyALL - Study on the Safety of Liposomal Amphotericin B to Prevent Antifungal Infections in Elderly Patients With Acute Lymphoblastic Leukemia Terminated NCT00386997 Phase 4 liposomal amphotericin B (AmBisome®)
9 Antifungal Prophylaxis in Pediatric Acute Leukemia Unknown status NCT00624143 Phase 3 ORAL VORICONAZOLE and IV Amphotericin B
10 A Study Comparing Single Versus Double Umbilical Cord Blood Transplantation in the Young With Acute Leukemia Remission Unknown status NCT01067300 Phase 3
11 Megakaryocytic Progenitor Cells for Prophylaxis and Treatment of Thrombocytopenia Unknown status NCT02241031 Phase 2, Phase 3 thrombopoietin (TPO) and interleukin-11
12 Decitabine Augments for Post Allogeneic Stem Cell Transplantation in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndrome Unknown status NCT01809392 Phase 2, Phase 3 decitabine
13 Evaluation of Plasmatic Levels of Busulfan in Patients Undergoing Hematopoietic Stem Cell Transplantation Unknown status NCT01800643 Phase 2, Phase 3
14 Thymoglobulin in Unrelated Hematopoietic Progenitor Cell Transplantation Unknown status NCT01217723 Phase 3
15 Clove In The Treatment Of Relapsed Or Resistant Acute Leukemia In Children Completed NCT01385891 Phase 2, Phase 3 Clofarabine VP 16 ciclophospahamide
16 Levofloxacin in Preventing Infection in Young Patients With Acute Leukemia Receiving Chemotherapy or Undergoing Stem Cell Transplantation Completed NCT01371656 Phase 3 levofloxacin
17 Chronic Graft-versus-host Disease (cGvHD) Prophylaxis With or Without ATG Prior to Stem Cell Transplantation (SCT) From HLA-identical Siblings in Patients With Acute Leukemia Completed NCT00678275 Phase 3 ATG FRESENIUS (Anti-Lymphocyte-Globulin);ATG FRESENIUS (Anti-Lymphocyte-Globulin)
18 Bone Marrow Transplantation in Treating Patients With Acute Leukemia in First or Second Remission Completed NCT00002534 Phase 3 cyclophosphamide;cytarabine;methylprednisolone;thiotepa
19 Peripheral Blood (PB) Versus Bone Marrow (BM) in Allogeneic Stem Cell Transplantation Completed NCT01020175 Phase 3
20 Busulfan Plus Cyclophosphamide vs Fludarabine as a Conditioning Regimen Completed NCT00774280 Phase 3 BuCy vs BuFlu
21 Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Acute Lymphoblastic Leukemia Completed NCT00002700 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;mitoxantrone hydrochloride;prednisolone;prednisone;therapeutic hydrocortisone;vincristine sulfate
22 Treatment of Acute Myeloid Leukemia (AML) in Adults 50 to 70 Years, Study of Two Anthracyclines and the Interest of Maintenance Treatment With Interleukin 2 Completed NCT00931138 Phase 3 chemotherapy (Aracytine + Daunorubicin);chemotherapy (Aracytine + Daunorubicin);chemotherapy (Aracytine + Daunorubicin)
23 A Randomized Study of Gemtuzumab Ozogamicin (GO) With Daunorubicine and Cytarabine in Untreated Acute Myeloid Leukemia (AML) Aged of 50-70 Years Old Completed NCT00927498 Phase 3 conventional chemotherapy (AraC + Daunorubicin),;Mylotarg associated with conventional chemotherapy (AraC + Daunorubicin),
24 Effect of Priming During Induction and Consolidations in Younger Acute Myeloid Leukemia (AML) Completed NCT00880243 Phase 3 GM-CSF
25 A Multicentre Randomised Controlled Trial Comparing Two Strategies for the Diagnosis of Invasive Aspergillosis in High-risk Haematology Patients Completed NCT00163722 Phase 3
26 Tipifarnib Versus Best Supportive Care in the Treatment of Newly Diagnosed Acute Myeloid Leukemia (AML) Completed NCT00093990 Phase 3 Tipifarnib;Zarnestra; R115777
27 Timed-Sequential Induction in CBF-AML Completed NCT00428558 Phase 3 Chemotherapy (DAUNORUBICINE-CYTARABINE);Chemotherapy (DAUNORUBICINE-CYTARABINE)
28 Efficacy/Safety of Frontline Alemtuzumab (Campath, MabCampath) vs Chlorambucil in Patients With Progressive B-Cell Lymphocytic Leukemia Completed NCT00046683 Phase 3 alemtuzumab
29 Prevention of Left Ventricular Dysfunction During Chemotherapy Completed NCT01110824 Phase 3 Enalapril and carvedilol
30 TK008: Efficacy Study on the Strategy of HSV-Tk Engineering Donor Lymphocytes to Treat Patients With High Risk Acute Leukemia Recruiting NCT00914628 Phase 3
31 Comparing Two Diets in Patients Undergoing HSCT or Remission Induction Chemo for Acute Leukemia and MDS (UF-BMT-LDND-101) Recruiting NCT03016130 Phase 3
32 Transfusion Strategy in Hematological Intensive Care Unit Recruiting NCT02461264 Phase 3 Single red blood packed cells Transfusion;Two packed red blood cells Transfusion
33 Calcineurin Inhibitor-Free Interventions for Prevention of Graft-versus-Host Disease (BMT CTN 1301) Recruiting NCT02345850 Phase 3 Cyclophosphamide;Tacrolimus;Methotrexate
34 MRD-directed Donor Lymphocyte Infusion for Reduce of Relapse After Allo-HSCT Recruiting NCT02673008 Phase 2, Phase 3
35 Transplantation of Ex Vivo Expanded, UCB-derived, Stem & Progenitor Cells vs. Unmanipulated UCB for HM Patients Recruiting NCT02730299 Phase 3 NiCord®
36 The Ruxolitinib Versus Best Available Therapy Trial in Patients With High Risk ET in Second Line Recruiting NCT02962388 Phase 2, Phase 3 Anagrelide;Ruxolitinib (JAKAVI®);IFNα/ PegIFNα
37 Ruxolitinib Efficacy and Safety in Patients With HU Resistant or Intolerant Polycythemia Vera vs Best Available Therapy. Recruiting NCT02038036 Phase 3 Best Available Therapy;ruxolitinib
38 Intergroup Randomized Trial for Children or Adolescents With B-Cell Non Hodgkin Lymphoma or B-Acute Leukemia: Rituximab Evaluation in High Risk Patients Active, not recruiting NCT01516580 Phase 3 Vincristine, cyclophosphamide, methotrexate, doxorubicin, cytarabine, ara-C;Rituximab, Vincristine, cyclophosphamide, methotrexate, doxorubicin, cytarabine, ara-C
39 Clofarabine or Daunorubicin Hydrochloride and Cytarabine Followed By Decitabine or Observation in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia Active, not recruiting NCT02085408 Phase 3 clofarabine;daunorubicin hydrochloride;cytarabine;decitabine
40 Study of REVLIMID (Lenalidomide) Versus Placebo in Patients With Low Risk Myelodysplastic Syndrome Active, not recruiting NCT01243476 Phase 3 Lenalidomide
41 Nonmyeloablative Preparative Regimen Using Mylotarg for Patients With High Risk Acute Myeloid Leukemia (AML), Acute Lymphocytic Leukemia (ALL), Chronic Myeloid Leukemia (CML) and Myelodysplastic Syndrome (MDS) Terminated NCT00038805 Phase 2, Phase 3 Mylotarg
42 A Randomized Study of Post-Remission Therapy in Elderly Patients With Acute Myelogenous Leukemia. Terminated NCT00363025 Phase 3 Idarubicin versus daunorubicin
43 Stem Cell Transplantation for Hematological Malignancies Terminated NCT00176839 Phase 2, Phase 3 Busulfan;Cyclophosphamide;Melphalan;G-CSF;ATG
44 Vadastuximab Talirine (SGN-CD33A; 33A) Combined With Azacitidine or Decitabine in Older Patients With Newly Diagnosed Acute Myeloid Leukemia Terminated NCT02785900 Phase 3 33A;placebo;azacitidine;decitabine
45 HCT Versus CT in Elderly AML Terminated NCT00766779 Phase 3 Non-Transplant treatment approach for consolidation
46 Intensive Glycemic Control on Infectious Morbidity In Patients With Acute Leukemia Withdrawn NCT00943709 Phase 3 therapeutic insulin
47 ALFA-0703 Study in Older Patients With Acute Myeloblastic Leukemia (AML) Withdrawn NCT01067274 Phase 3 Vesanoid (ATRA);AZACITIDINE (VIDAZA);CYTARABINE
48 Pilot Study of Hematopoietic Stem Cell Transplantation From Two Matched Sibling Donors in Treating Patients With Poor Prognosis Acute Leukemia and Advanced Lymphoproliferative Malignancies Unknown status NCT01385072 Phase 1, Phase 2
49 Pharmacokinetic Study of Busulfan in Allogeneic Stem Cell Transplantation in Adult Patients With Acute Leukemia Unknown status NCT01498016 Phase 2 Busulfan
50 Clinical Study of DC Plus CIK for Patients With Relapse Acute Leukemia After Allo-HSCT Unknown status NCT01956630 Phase 1, Phase 2

Search NIH Clinical Center for Acute Leukemia

Cell-based therapeutics:

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Acute Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Acute Leukemia:

Genetic Tests for Acute Leukemia

Genetic tests related to Acute Leukemia:

# Genetic test Affiliating Genes
1 Acute Leukemia 29

Anatomical Context for Acute Leukemia

MalaCards organs/tissues related to Acute Leukemia:

Myeloid, Bone, Bone Marrow, T Cells, B Cells, Nk Cells, Liver

Publications for Acute Leukemia

Articles related to Acute Leukemia:

(show top 50) (show all 1963)
# Title Authors Year
Acute leukemia cells resistant to PI3K/mTOR inhibition display upregulation of P2RY14 expression. ( 29951132 )
A greater birthweight increases the risk of acute leukemias in Mexican children-experience from the Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia (MIGICCL). ( 29533016 )
Comparable survival using a CMV-matched or a mismatched donor for CMV+ patients undergoing T-replete haplo-HSCT with PT-Cy for acute leukemia: a study of behalf of the infectious diseases and acute leukemia working parties of the EBMT. ( 29330396 )
Association between (GT)n Repeats in Heme Oxygenase-1 Gene Promoter and 3-Year Survival of Patients with Acute Leukemia: a Controlled, Cross-Sectional Study. ( 29951178 )
Impact of antithymocyte globulin doses in reduced intensity conditioning before allogeneic transplantation from matched sibling donor for patients with acute myeloid leukemia: a report from the acute leukemia working party of European group of Bone Marrow Transplantation. ( 29330391 )
Risk factors for mortality in patients with acute leukemia and bloodstream infections in the era of multiresistance. ( 29953464 )
Maternal Exposure to Pesticides, Paternal Occupation in the Army/Police Force, and CYP2D6*4 Polymorphism in the Etiology of Childhood Acute Leukemia. ( 29432309 )
Re-induction chemotherapy using FLAG-mitoxantrone for adult patients with relapsed acute leukemia: a single-center experience from United Arab Emirates. ( 29951735 )
Determination of CEBPA mutations by next generation sequencing in pediatric acute leukemia. ( 29947237 )
Fibroblast Growth Factor 23-Induced Hypophosphatemia in Acute Leukemia. ( 29696242 )
Relatively favorable prognosis for MLL-rearranged childhood acute leukemia with reciprocal translocations. ( 29943896 )
Intravenous Busulfan Compared with Treosulfan-Based Conditioning for Allogeneic Stem Cell Transplantation in Acute Myeloid Leukemia: A Study on Behalf of the Acute Leukemia Working Party of European Society for Blood and Marrow Transplantation. ( 29247780 )
Salvaged allogeneic hematopoietic stem cell transplantation for pediatric chemotherapy refractory acute leukemia. ( 29423036 )
Prevalence and Predictors of Invasive Fungal Infections in Children with Persistent Febrile Neutropenia Treated for Acute Leukemia - A Prospective Study. ( 29956075 )
Flow cytometric characterization of acute leukemia reveals a distinctive "blast gate" of murine T-lymphoblastic leukemia/lymphoma. ( 29416774 )
The safety and efficacy of clofarabine in combination with high-dose cytarabine and total body irradiation myeloablative conditioning and allogeneic stem cell transplantation in children, adolescents, and young adults (CAYA) with poor-risk acute leukemia. ( 29899571 )
Hyperleukocytosis in infant acute leukemia: a role for manual exchange transfusion for leukoreduction. ( 29399859 )
Clinical significance of the TNF-I+ receptors, TNFRSF2 and TNFRSF9, on cell migration molecules Fascin-1 and Versican in acute leukemia. ( 29861382 )
Secondary Philadelphia chromosome acquired during therapy of acute leukemia and myelodysplastic syndrome. ( 29449681 )
Congestive heart failure among children with acute leukemia: a population-based matched cohort study. ( 29966479 )
Measurable residual disease, conditioning regimen intensity and age predict outcome of allogeneic hematopoietic cell transplantation for acute myeloid leukemia in first remission: a registry analysis of 2292 patients by the Acute Leukemia Working Party European Society of Blood and Marrow Transplantation. ( 29981272 )
VEGF signaling in acute leukemia: mitochondrial connections. ( 29854867 )
Clinicohematological Profile of Febrile Neutropenia in Childhood Acute Leukemia and Utility of Serum Procalcitonin Levels in Neutropenic Patients. ( 29910543 )
Secondary Acute Leukemia in Sarcoma Patients: A Population-Based Study. ( 29413281 )
Stodtmeister Cells (Polymorphs with Pelger-HuA<t Anomaly) Showing &amp;quot;Faggots&amp;quot; in Mixed Phenotypic Acute Leukemia (T/Myeloid). ( 29398816 )
Derepression of the Iroquois Homeodomain Transcription Factor Gene IRX3 Confers Differentiation Block in Acute Leukemia. ( 29346763 )
Moxifloxacin versus levofloxacin for antibacterial prophylaxis in acute leukemia patients. ( 29310512 )
Novel biallelic ATM mutations coexist with a mosaic form of triple X syndrome in an 11-year-old girl at remission after T cell acute leukemia. ( 29492593 )
Oral health status in adult patients with newly diagnosed acute leukemia. ( 28536781 )
Mometasone furoate inhibits growth of acute leukemia cells in childhood by regulating PI3K signaling pathway. ( 29421985 )
Clinical and Genomic Characterization of Recurrent Enterococcal Bloodstream Infection in Patients With Acute Leukemia. ( 29977964 )
Pentraxin-3 polymorphisms and invasive mold infections in acute leukemia patients with intensive chemotherapy. ( 29880612 )
Anti-D Alloimmunization after RhD-Positive Platelet Transfusion in RhD-Negative Women under 55 Years Diagnosed with Acute Leukemia: Results of a Retrospective Study. ( 29928170 )
Chronic disseminated candidiasis and acute leukemia: Impact on survival and hematopoietic stem cell transplantation agenda. ( 29307444 )
Single Dose Daily Fractionated Is Not Inferior To Twice A Day Fractionated Total Body Irradiation Prior To Allogeneic Stem Cell Transplantation For Acute Leukemia: A Useful Practice Simplification Resulting From The Sarasin Study. ( 29928948 )
Diagnostic Dilemma in Ambiguous Lineage Acute Leukemia: A Case Report. ( 29398827 )
Acute bilateral retina hemorrhages beneath internal limiting membrane: An unusual ophthalmological case report of acute leukemia during complete clinical remission. ( 29443727 )
Targeting the bone marrow microenvironment in acute leukemia. ( 29431560 )
Hematopoietic cell transplantation for myeloid/NK cell precursor acute leukemia in second remission. ( 29881556 )
Clinical Outcome, Healthcare Cost and Length of Hospital Stay Among Patients With Bloodstream Infections and Acute Leukemia in a Cancer Center in Eastern India. ( 29909820 )
Clinical significance of HLA-E genotype and surface/soluble expression levels between healthy individuals and patients with acute leukemia. ( 29969046 )
Surface endoglin (CD105) expression on acute leukemia blast cells: an extensive flow cytometry study of 1002 patients. ( 29334284 )
A protocol to isolate and qualify purified human preantral follicles in cases of acute leukemia, for future clinical applications. ( 29304838 )
Acute Leukemia is Associated with Cardiac Alterations before Chemotherapy. ( 28927558 )
Genomic characterization of chromosome translocations in patients with T/myeloid mixed-phenotype acute leukemia. ( 28882084 )
Bone Marrow Necrosis in Newly Diagnosed Acute Leukemia: Two Case Reports and Review of the Literature. ( 28680961 )
Lymphocyte recovery is an independent predictor of relapse in allogeneic hematopoietic cell transplantation recipients for acute leukemia. ( 28900606 )
Typhlitis (neutropenic enterocolitis) in patients with acute leukemia: a review. ( 28075196 )
Risk factors in patients undergoing haploidentical hematopoietic stem cell transplantation for high-risk childhood acute leukemia. ( 28825215 )
Leukemic phase of hepatosplenic T-cell lymphoma: A great masquerader of acute leukemia. ( 28937394 )

Variations for Acute Leukemia

Expression for Acute Leukemia

Search GEO for disease gene expression data for Acute Leukemia.

Pathways for Acute Leukemia

GO Terms for Acute Leukemia

Cellular components related to Acute Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.4 BAALC DNTT ETV6 FLT3 GSTM1 JAK2

Biological processes related to Acute Leukemia according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.95 CEBPA CREBBP KMT2A RUNX1 WT1
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.95 CEBPA CREBBP CSF3 ETV6 KMT2A RUNX1
3 transcription by RNA polymerase II GO:0006366 9.8 CEBPA ETV6 KMT2A MLLT1 RUNX1 WT1
4 positive regulation of DNA binding transcription factor activity GO:0051091 9.7 CSF3 JAK2 KIT
5 cytokine-mediated signaling pathway GO:0019221 9.65 CEBPA CSF3 FLT3 JAK2 KIT
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.61 FLT3 JAK2 KIT
7 macrophage differentiation GO:0030225 9.51 CEBPA CSF3
8 embryonic hemopoiesis GO:0035162 9.49 KIT KMT2A
9 regulation of myeloid cell differentiation GO:0045637 9.48 CREBBP RUNX1
10 granulocyte differentiation GO:0030851 9.46 CEBPA CSF3
11 hemopoiesis GO:0030097 9.46 CD34 FLT3 KIT RUNX1
12 myeloid progenitor cell differentiation GO:0002318 9.37 FLT3 KIT
13 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.26 CSF3 FLT3 JAK2 KIT
14 hematopoietic stem cell proliferation GO:0071425 8.8 CD34 ETV6 RUNX1
15 cell differentiation GO:0030154 10.01 ANPEP ETV6 FLT3 JAK2 KIT STMN1

Molecular functions related to Acute Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region DNA binding GO:0044212 9.26 CEBPA KMT2A RUNX1 WT1
2 DNA binding transcription factor activity GO:0003700 9.17 AFF1 CEBPA CREBBP ETV6 KMT2A RUNX1

Sources for Acute Leukemia

9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
70 SNOMED-CT via Orphanet
72 Tocris
74 UMLS via Orphanet
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