MCID: ACT073
MIFTS: 59

Acute Leukemia

Categories: Blood diseases, Bone diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Acute Leukemia

MalaCards integrated aliases for Acute Leukemia:

Name: Acute Leukemia 12 29 55 15 38 17 72
Acute Undifferentiated Leukemia 72
Undifferentiated Leukemia 72
Stem Cell Leukaemia 12
Stem Cell Leukemia 12
Acute Leukemias 15

Classifications:



External Ids:

Disease Ontology 12 DOID:12603
ICD9CM 35 208.0
NCIt 50 C9300
SNOMED-CT 68 24072005 91855006
ICD10 33 C95.0 C95.00
UMLS 72 C0085669 C0280141 C1378511

Summaries for Acute Leukemia

Disease Ontology : 12 A leukemia that occurs when a hematopoietic stem cell undergoes malignant transformation into a primitive, undifferentiated cell with abnormal longevity. These lymphocytes (acute lymphocytic leukemia [ALL]) or myeloid cells (acute myelocytic leukemia [AML]) proliferate abnormally, replacing normal marrow tissue and hematopoietic cells and inducing anemia, thrombocytopenia, and granulocytopenia.

MalaCards based summary : Acute Leukemia, also known as acute undifferentiated leukemia, is related to childhood leukemia and megakaryocytic leukemia. An important gene associated with Acute Leukemia is WT1 (WT1 Transcription Factor), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Arsenic trioxide and Micafungin have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow, and related phenotypes are no effect and hematopoietic system

Wikipedia : 75 Acute leukemia or acute leukaemia is a family of serious medical conditions relating to an original... more...

Related Diseases for Acute Leukemia

Diseases in the Leukemia family:

Chronic Leukemia Acute Leukemia
Subacute Leukemia

Diseases related to Acute Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 836, show less)
# Related Disease Score Top Affiliating Genes
1 childhood leukemia 32.9 RUNX1 MTHFR MLLT3 KMT2A ETV6
2 megakaryocytic leukemia 32.9 RUNX1 MPO JAK2
3 acute promyelocytic leukemia 32.6 WT1 RUNX1 MPO FLT3 CSF3 CEBPA
4 lymphoblastic lymphoma 32.6 MPO KMT2A DNTT
5 leukemia, acute lymphoblastic 32.2 RUNX1 PAX5 KMT2A FLT3 ETV6 DNTT
6 leukemia 32.0 WT1 RUNX1 MLLT3 KIT JAK2 FLT3
7 lymphocytic leukemia 31.9 RUNX1 PAX5 KMT2A ETV6 DNTT
8 acute myeloblastic leukemia with maturation 31.5 KIT FLT3
9 myelofibrosis 31.0 KIT JAK2 FLT3 CSF3
10 myeloid leukemia 31.0 WT1 RUNX1 KIT JAK2 FLT3 ETV6
11 leukemia, acute myeloid 30.8 WT1 RUNX1 MPO MLLT3 KMT2A KIT
12 acute erythroid leukemia 30.8 JAK2 CEBPA
13 leukemia, acute monocytic 30.8 MPO MLLT3 KMT2A CREBBP
14 chronic myelomonocytic leukemia 30.8 RUNX1 KIT JAK2 FLT3 ETV6
15 precursor t-cell acute lymphoblastic leukemia 30.6 MPO KMT2A FLT3 ETV6 DNTT ANPEP
16 chronic eosinophilic leukemia 30.6 WT1 KIT FLT3
17 subacute myeloid leukemia 30.5 JAK2 FLT3
18 lymphoma, non-hodgkin, familial 30.5 PAX5 JAK2 DNTT CSF3
19 blood coagulation disease 30.4 MTHFR JAK2 CSF3
20 nondisjunction 30.4 MTHFR KIT
21 acute myeloid leukemia with minimal differentiation 30.3 MPO FLT3
22 8p11 myeloproliferative syndrome 30.3 RUNX1 KIT FLT3
23 cytogenetically normal acute myeloid leukemia 30.2 WT1 KMT2A FLT3 CEBPA
24 myelodysplastic syndrome 30.2 WT1 RUNX1 KMT2A KIT JAK2 GSTM1
25 hypereosinophilic syndrome, idiopathic 30.1 WT1 KIT
26 blood platelet disease 30.1 RUNX1 JAK2 CSF3
27 acute basophilic leukemia 30.1 MPO ETV6
28 tetrasomy 21 30.0 RUNX1 DNTT ANPEP
29 neonatal leukemia 30.0 MLLT3 FLT3 CREBBP AFF1
30 leukemia, acute lymphoblastic 3 29.8 RUNX1 PAX5 MPO KMT2A FLT3 ETV6
31 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 29.7 RUNX1 MPO KMT2A KIT FLT3 ETV6
32 leukemia, chronic myeloid 29.6 WT1 RUNX1 MPO KMT2A KIT JAK2
33 small cell cancer of the lung 29.6 PAX5 KIT CSF3
34 myeloid sarcoma 29.6 PAX5 MPO KMT2A KIT FLT3 DNTT
35 core binding factor acute myeloid leukemia 29.3 WT1 RUNX1 KIT JAK2 FLT3 CSF3
36 hematologic cancer 28.7 WT1 RUNX1 PAX5 KMT2A KIT JAK2
37 acute leukemia of ambiguous lineage 12.6
38 chromosome 8p11 myeloproliferative syndrome 12.0
39 invasive aspergillosis 11.5
40 myeloproliferative neoplasm 11.5
41 chronic leukemia 11.5
42 severe congenital neutropenia 11.5
43 myelodysplastic/myeloproliferative neoplasm 11.5
44 hematopoietic stem cell transplantation 10.8
45 graft-versus-host disease 10.8
46 acute myeloid leukemia with t(9;11)(p22;q23) 10.8 MLLT3 KMT2A
47 ring chromosome 21 10.8 KMT2A ETV6
48 neutropenia 10.7
49 testicular gonadoblastoma 10.7 WT1 KIT
50 acute graft versus host disease 10.7
51 b-cell childhood acute lymphoblastic leukemia 10.7 RUNX1 ETV6
52 chromophobe renal cell carcinoma 10.6
53 renal oncocytoma 10.6
54 diffuse peritoneal leiomyomatosis 10.6 WT1 KIT
55 congenital mesoblastic nephroma 10.6 WT1 KIT ETV6
56 lymphoma 10.6
57 mucositis 10.6
58 peritoneal benign neoplasm 10.6 WT1 KIT
59 malignant mesenchymoma 10.6 WT1 KIT ETV6
60 thrombocytopenia 10.5
61 aspergillosis 10.5
62 granulocytopenia 10.5
63 aplastic anemia 10.5
64 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 10.5
65 candidiasis 10.5
66 myelophthisic anemia 10.5 JAK2 ANPEP
67 chronic graft versus host disease 10.5
68 chromosomal triplication 10.5
69 arteritic anterior ischemic optic neuropathy 10.5 MTHFR MPO GSTM1
70 acute myeloid leukemia with t(8;21)(q22;q22) translocation 10.5 RUNX1 KIT FLT3 CEBPA
71 malignant leydig cell tumor 10.5 PAX5 KIT
72 pancytopenia 10.5
73 deficiency anemia 10.4
74 myeloma, multiple 10.4
75 down syndrome 10.4
76 disseminated intravascular coagulation 10.4
77 acute t cell leukemia 10.4
78 testicular infarct 10.4 MTHFR KIT
79 acute monoblastic leukemia 10.4
80 monocytic leukemia 10.4
81 refractory anemia 10.4
82 acute non lymphoblastic leukemia 10.4
83 leukocyte disease 10.4 PAX5 KIT CSF3
84 childhood acute lymphocytic leukemia 10.4
85 stomatitis 10.4
86 wilms tumor 5 10.4
87 polycythemia 10.3
88 splenomegaly 10.3
89 lymphoma, hodgkin, classic 10.3
90 polycythemia vera 10.3
91 bacterial infectious disease 10.3
92 cystic nephroma 10.3 WT1 KIT
93 leukemia, chronic lymphocytic 10.3
94 leukemia, b-cell, chronic 10.3
95 alopecia 10.3
96 47,xyy 10.3
97 mast-cell sarcoma 10.3 MPO KIT ANPEP
98 respiratory failure 10.3
99 burkitt lymphoma 10.3
100 enterocolitis 10.3
101 chickenpox 10.3
102 erythroleukemia, familial 10.3
103 leukostasis 10.3
104 pfeiffer syndrome 10.2
105 rhabdomyosarcoma 10.2
106 lymphosarcoma 10.2
107 sarcoma 10.2
108 t-cell leukemia 10.2
109 mucormycosis 10.2
110 bilirubin metabolic disorder 10.2
111 severe combined immunodeficiency 10.2
112 homologous wasting disease 10.2
113 aleukemic leukemia cutis 10.2 RUNX1 MPO FLT3 ANPEP
114 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.2
115 spindle cell sarcoma 10.2
116 neuroblastoma 1 10.2
117 hepatic veno-occlusive disease 10.2
118 purpura 10.2
119 acute kidney failure 10.2
120 leukemia, t-cell, chronic 10.2
121 diarrhea 10.2
122 thrombocytosis 10.2
123 pneumonia 10.2
124 breast cancer 10.2
125 ovarian cancer 10.2
126 essential thrombocythemia 10.2
127 acute myeloblastic leukemia without maturation 10.2
128 refractory anemia with excess blasts in transformation 10.2
129 exanthem 10.1
130 hemosiderosis 10.1
131 toxic shock syndrome 10.1
132 hypothyroidism 10.1
133 appendicitis 10.1
134 rare hereditary hemochromatosis 10.1
135 platelet disorder, familial, with associated myeloid malignancy 10.1 RUNX1 ETV6
136 thrombosis 10.1
137 endocarditis 10.1
138 central nervous system leukemia 10.1
139 diabetes insipidus 10.1
140 pulmonary edema 10.1
141 pericarditis 10.1
142 hyperuricemia 10.1
143 lactic acidosis 10.1
144 chronic monocytic leukemia 10.1
145 sideroblastic anemia 10.1
146 macroglobulinemia 10.1
147 exophthalmos 10.1
148 hypereosinophilic syndrome 10.1
149 autoimmune disease 10.1
150 retinoblastoma 10.1
151 thrombophilia due to thrombin defect 10.1
152 wilms tumor 1 10.1
153 rhabdomyosarcoma 2 10.1
154 hemorrhagic cystitis 10.1
155 paroxysmal nocturnal hemoglobinuria 10.1
156 cystitis 10.1
157 hepatitis b 10.1
158 familial retinoblastoma 10.1
159 hemoglobinuria 10.1
160 b-cell lymphoma 10.1
161 meningitis 10.1
162 cytokine deficiency 10.1
163 reticulum cell sarcoma 10.0
164 histiocytosis 10.0
165 hypokalemia 10.0
166 congestive heart failure 10.0
167 herpes simplex 10.0
168 acute respiratory distress syndrome 10.0
169 polykaryocytosis inducer 10.0
170 thrombocytopenic purpura, autoimmune 10.0
171 ataxia and polyneuropathy, adult-onset 10.0
172 fusariosis 10.0
173 osteonecrosis 10.0
174 osteomyelitis 10.0
175 oral candidiasis 10.0
176 viral hepatitis 10.0
177 constipation 10.0
178 pyoderma 10.0
179 conjunctivitis 10.0
180 pyoderma gangrenosum 10.0
181 measles 10.0
182 neuropathy 10.0
183 pulmonary embolism 10.0
184 48,xyyy 10.0
185 bone marrow necrosis 10.0
186 tetraploidy 10.0
187 langerhans cell histiocytosis 10.0
188 hypophosphatemia 10.0
189 mumps 10.0
190 hemopericardium 10.0
191 patau syndrome 10.0
192 pericardial effusion 10.0
193 telangiectasis 10.0
194 liver disease 10.0
195 combined t cell and b cell immunodeficiency 10.0
196 juvenile rheumatoid arthritis 10.0
197 arthritis 10.0
198 myelodysplastic syndrome with excess blasts 10.0
199 avascular necrosis 10.0
200 pernicious anemia 9.9
201 retinal detachment 9.9
202 rheumatoid arthritis 9.9
203 ataxia-telangiectasia 9.9
204 ocular motor apraxia 9.9
205 osteogenic sarcoma 9.9
206 mycobacterium tuberculosis 1 9.9
207 hypopyon 9.9
208 esophagitis 9.9
209 allergic hypersensitivity disease 9.9
210 pneumothorax 9.9
211 hypogonadism 9.9
212 hairy cell leukemia 9.9
213 gingival overgrowth 9.9
214 hyperglycemia 9.9
215 kidney disease 9.9
216 peripheral nervous system disease 9.9
217 hemolytic anemia 9.9
218 paraplegia 9.9
219 hypogonadotropism 9.9
220 cataract 9.9
221 herpes zoster 9.9
222 diabetes mellitus 9.9
223 hypoglycemia 9.9
224 cytomegalovirus infection 9.9
225 encephalopathy 9.9
226 headache 9.9
227 posttransplant acute limbic encephalitis 9.9
228 argyria 9.9
229 rare tumor 9.9
230 endosteal hyperostosis, autosomal dominant 9.9
231 kaposi sarcoma 9.9
232 medulloblastoma 9.9
233 neurofibromatosis, type iv, of riccardi 9.9
234 hemochromatosis, type 1 9.9
235 helix syndrome 9.9
236 small cell carcinoma 9.9
237 mantle cell lymphoma 9.9
238 bone disease 9.9
239 tetanus 9.9
240 adult respiratory distress syndrome 9.9
241 cardiac tamponade 9.9
242 nephrotic syndrome 9.9
243 ecthyma 9.9
244 megaloblastic anemia 9.9
245 melanoma 9.9
246 factor xiii deficiency 9.9
247 iron metabolism disease 9.9
248 glioblastoma multiforme 9.9
249 astrocytoma 9.9
250 mastocytosis 9.9
251 thrombophlebitis 9.9
252 uremia 9.9
253 acute stress disorder 9.9
254 hyperthyroidism 9.9
255 periodontitis 9.9
256 hodgkin's lymphoma, lymphocytic-histiocytic predominance 9.9
257 vasculitis 9.9
258 germ cells tumors 9.9
259 glioblastoma 9.9
260 pik3ca-related overgrowth syndrome 9.9
261 thyroid carcinoma 9.9
262 colorectal cancer 9.8
263 cardiac arrhythmia 9.8
264 fibrosis of extraocular muscles, congenital, 1 9.8
265 systemic lupus erythematosus 9.8
266 pelger-huet anomaly 9.8
267 triiodothyronine receptor auxiliary protein 9.8
268 yemenite deaf-blind hypopigmentation syndrome 9.8
269 body mass index quantitative trait locus 1 9.8
270 hepatitis c virus 9.8
271 gastric cancer 9.8
272 adult t-cell leukemia 9.8
273 diffuse large b-cell lymphoma 9.8
274 colitis 9.8
275 hypogonadotropic hypogonadism 9.8
276 prolymphocytic leukemia 9.8
277 diphtheria 9.8
278 iron deficiency anemia 9.8
279 goiter 9.8
280 cholestasis 9.8
281 rheumatic fever 9.8
282 thrombocytopenia due to platelet alloimmunization 9.8
283 hepatitis c 9.8
284 cholecystitis 9.8
285 hepatitis 9.8
286 gastroenteritis 9.8
287 dermatitis 9.8
288 acute pancreatitis 9.8
289 gingivitis 9.8
290 cellulitis 9.8
291 plasmacytoma 9.8
292 pustulosis of palm and sole 9.8
293 endophthalmitis 9.8
294 poliomyelitis 9.8
295 infertility 9.8
296 lung oat cell carcinoma 9.8
297 adult acute lymphocytic leukemia 9.8
298 peritonitis 9.8
299 influenza 9.8
300 reticulosarcoma 9.8
301 bacterial pneumonia 9.8
302 rubella 9.8
303 psoriasis 9.8
304 learning disability 9.8
305 amyloidosis 9.8
306 cholangitis 9.8
307 toxoplasmosis 9.8
308 blastic plasmacytoid dendritic cell 9.8
309 dendritic cell tumor 9.8
310 glioma 9.8
311 haemophilus influenzae 9.8
312 pseudo pelger-huet anomaly 9.8
313 depression 9.8
314 back pain 9.8
315 hypoxia 9.8
316 lymphedema 9.8
317 hepatosplenic t-cell lymphoma 9.8
318 red cell aplasia 9.8
319 multiple sclerosis 9.7
320 hair whorl 9.7
321 neurofibromatosis, type i 9.7
322 pneumothorax, primary spontaneous 9.7
323 prostate cancer 9.7
324 dowling-degos disease 1 9.7
325 bloom syndrome 9.7
326 chediak-higashi syndrome 9.7
327 cystic fibrosis 9.7
328 fanconi anemia, complementation group d2 9.7
329 fanconi anemia, complementation group a 9.7
330 homocystinuria due to deficiency of n -methylenetetrahydrofolate reductase activity 9.7
331 body mass index quantitative trait locus 11 9.7
332 retinitis pigmentosa 11 9.7
333 body mass index quantitative trait locus 9 9.7
334 body mass index quantitative trait locus 8 9.7
335 omenn syndrome 9.7
336 nasopharyngeal carcinoma 9.7
337 body mass index quantitative trait locus 4 9.7
338 body mass index quantitative trait locus 10 9.7
339 juvenile myelomonocytic leukemia 9.7
340 neutrophilic dermatosis, acute febrile 9.7
341 body mass index quantitative trait locus 7 9.7
342 ewing sarcoma 9.7
343 body mass index quantitative trait locus 12 9.7
344 body mass index quantitative trait locus 14 9.7
345 lymphedema, primary, with myelodysplasia 9.7
346 body mass index quantitative trait locus 18 9.7
347 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.7
348 hydrops, lactic acidosis, and sideroblastic anemia 9.7
349 spastic paraplegia, intellectual disability, nystagmus, and obesity 9.7
350 body mass index quantitative trait locus 19 9.7
351 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 9.7
352 body mass index quantitative trait locus 20 9.7
353 bacterial sepsis 9.7
354 trichosporonosis 9.7
355 hyperphosphatemia 9.7
356 metabolic acidosis 9.7
357 infective endocarditis 9.7
358 ptosis 9.7
359 cardiac arrest 9.7
360 lymphoproliferative syndrome 9.7
361 cytomegalovirus retinitis 9.7
362 neuroretinitis 9.7
363 thalassemia 9.7
364 parotitis 9.7
365 natural killer cell leukemia 9.7
366 viral pneumonia 9.7
367 meningoencephalitis 9.7
368 thrombotic thrombocytopenic purpura 9.7
369 brucellosis 9.7
370 hydronephrosis 9.7
371 pertussis 9.7
372 chlamydia 9.7
373 cauda equina syndrome 9.7
374 aseptic meningitis 9.7
375 testicular leukemia 9.7
376 uveitis 9.7
377 porphyria 9.7
378 klebsiella pneumonia 9.7
379 polyneuropathy 9.7
380 facial paralysis 9.7
381 capillary leak syndrome 9.7
382 panniculitis 9.7
383 urticaria 9.7
384 lymphadenitis 9.7
385 histoplasmosis 9.7
386 status epilepticus 9.7
387 optic nerve disease 9.7
388 post-traumatic stress disorder 9.7
389 granulomatous hepatitis 9.7
390 colon adenocarcinoma 9.7
391 macrocytic anemia 9.7
392 thrombophilia 9.7
393 testicular disease 9.7
394 splenic abscess 9.7
395 synovitis 9.7
396 severe acute respiratory syndrome 9.7
397 anuria 9.7
398 adenocarcinoma 9.7
399 malignant glioma 9.7
400 early myoclonic encephalopathy 9.7
401 ischemia 9.7
402 teratoma 9.7
403 plague 9.7
404 systemic mastocytosis 9.7
405 choriocarcinoma 9.7
406 retinitis 9.7
407 gastritis 9.7
408 tricuspid valve insufficiency 9.7
409 juvenile xanthogranuloma 9.7
410 pancreatitis 9.7
411 ureteral obstruction 9.7
412 urinary tract obstruction 9.7
413 hypersplenism 9.7
414 cerebrovascular disease 9.7
415 precursor b lymphoblastic lymphoma/leukemia 9.7
416 active peptic ulcer disease 9.7
417 septic arthritis 9.7
418 myocarditis 9.7
419 intestinal obstruction 9.7
420 ileus 9.7
421 lung disease 9.7
422 ulcerative colitis 9.7
423 pyomyositis 9.7
424 lupus erythematosus 9.7
425 chorioretinitis 9.7
426 encephalitis 9.7
427 b- and t-cell mixed leukemia 9.7
428 mosaic trisomy 8 9.7
429 parainfluenza virus type 3 9.7
430 plasma cell leukemia 9.7
431 syndrome of inappropriate antidiuretic hormone 9.7
432 systemic capillary leak syndrome 9.7
433 tremor 9.7
434 glial tumor 9.7
435 trisomy 1q 9.7
436 bullous pyoderma gangrenosum 9.7
437 acute liver failure 9.7
438 thrombotic microangiopathy 9.7
439 overgrowth syndrome 9.7
440 priapism 9.7
441 acanthosis nigricans 9.6
442 alzheimer disease 9.6
443 aryl hydrocarbon hydroxylase inducibility 9.6
444 atrial standstill 1 9.6
445 bladder cancer 9.6
446 progressive familial heart block, type ia 9.6
447 gilbert syndrome 9.6
448 hypertriglyceridemia, familial 9.6
449 intussusception 9.6
450 kabuki syndrome 1 9.6
451 lipomatosis, multiple 9.6
452 lymphatic malformation 5 9.6
453 chromosome 5q deletion syndrome 9.6
454 meckel diverticulum 9.6
455 ataxia-pancytopenia syndrome 9.6
456 neutrophilia, hereditary 9.6
457 noonan syndrome 1 9.6
458 osteoporosis 9.6
459 otitis media 9.6
460 nephrolithiasis, calcium oxalate 9.6
461 pheochromocytoma 9.6
462 porphyria cutanea tarda 9.6
463 axenfeld-rieger syndrome, type 1 9.6
464 aplasia of lacrimal and salivary glands 9.6
465 sarcoidosis 1 9.6
466 neural tube defects 9.6
467 temporal arteritis 9.6
468 neutropenia, severe congenital, 1, autosomal dominant 9.6
469 anemia, autoimmune hemolytic 9.6
470 autism 9.6
471 lung cancer 9.6
472 celiac disease 1 9.6
473 cryptorchidism, unilateral or bilateral 9.6
474 hemolytic uremic syndrome, atypical 1 9.6
475 immune deficiency disease 9.6
476 acetylation, slow 9.6
477 monosomy 7 of bone marrow 9.6
478 mycosis fungoides 9.6
479 scott syndrome 9.6
480 pyruvate kinase deficiency of red cells 9.6
481 insulin-like growth factor i 9.6
482 thymoma, familial 9.6
483 mismatch repair cancer syndrome 9.6
484 xeroderma pigmentosum, complementation group d 9.6
485 xeroderma pigmentosum, variant type 9.6
486 sarcoma, synovial 9.6
487 arts syndrome 9.6
488 hemophilia b 9.6
489 leukemia, acute, x-linked 9.6
490 androgen insensitivity, partial 9.6
491 budd-chiari syndrome 9.6
492 prostate cancer, hereditary, 1 9.6
493 branchiootic syndrome 1 9.6
494 homocysteinemia 9.6
495 acromelic frontonasal dysostosis 9.6
496 ventricular fibrillation, paroxysmal familial, 1 9.6
497 sickle cell anemia 9.6
498 cervical cancer 9.6
499 aceruloplasminemia 9.6
500 progressive familial heart block, type ib 9.6
501 meningioma, radiation-induced 9.6
502 polysubstance abuse 9.6
503 gastrointestinal stromal tumor 9.6
504 meningioma, familial 9.6
505 coronary heart disease 1 9.6
506 endometrial cancer 9.6
507 legionnaire disease 9.6
508 pseudohyperkalemia, familial, 2, due to red cell leak 9.6
509 human immunodeficiency virus type 1 9.6
510 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.6
511 chromosome 16p13.3 deletion syndrome, proximal 9.6
512 bone mineral density quantitative trait locus 8 9.6
513 hemolytic anemia, cd59-mediated, with or without immune-mediated polyneuropathy 9.6
514 lung cancer susceptibility 3 9.6
515 premature ovarian failure 7 9.6
516 neuroblastoma 2 9.6
517 bone mineral density quantitative trait locus 15 9.6
518 myxoid liposarcoma 9.6
519 bacteremia 2 9.6
520 membranous nephropathy 9.6
521 prostate cancer, hereditary, 2 9.6
522 human herpesvirus 8 9.6
523 alacrima, achalasia, and mental retardation syndrome 9.6
524 carbonic anhydrase va deficiency, hyperammonemia due to 9.6
525 b-cell expansion with nfkb and t-cell anergy 9.6
526 lung disease, immunodeficiency, and chromosome breakage syndrome 9.6
527 gastrointestinal ulceration, recurrent, with dysfunctional platelets 9.6
528 t-cell lymphoma, subcutaneous panniculitis-like 9.6
529 congenital methemoglobinemia 9.6
530 chlamydia pneumonia 9.6
531 hemophagocytic lymphohistiocytosis 9.6
532 secretory diarrhea 9.6
533 superficial mycosis 9.6
534 pulmonary aspergilloma 9.6
535 congenital hypothyroidism 9.6
536 foodborne botulism 9.6
537 multinodular goiter 9.6
538 variola major 9.6
539 inflammatory bowel disease 9.6
540 vitamin b12 deficiency 9.6
541 anaplastic large cell lymphoma 9.6
542 lymphoplasmacytic lymphoma 9.6
543 peripheral t-cell lymphoma 9.6
544 paraganglioma 9.6
545 secondary progressive multiple sclerosis 9.6
546 atrioventricular block 9.6
547 limb ischemia 9.6
548 follicular lymphoma 9.6
549 adrenal gland pheochromocytoma 9.6
550 interleukin-7 receptor alpha deficiency 9.6
551 immunoglobulin alpha deficiency 9.6
552 autosomal recessive pyridoxine-refractory sideroblastic anemia 2 9.6
553 crest syndrome 9.6
554 angular cheilitis 9.6
555 ectopic pregnancy 9.6
556 bacillary angiomatosis 9.6
557 nut midline carcinoma 9.6
558 b-cell adult acute lymphocytic leukemia 9.6
559 atypical chronic myeloid leukemia 9.6
560 bone resorption disease 9.6
561 myoglobinuria 9.6
562 non-alcoholic fatty liver disease 9.6
563 sensorineural hearing loss 9.6
564 pleomorphic lipoma 9.6
565 pleurisy 9.6
566 siderosis 9.6
567 tonsillitis 9.6
568 common cold 9.6
569 microinvasive gastric cancer 9.6
570 osteomalacia 9.6
571 glucose intolerance 9.6
572 fanconi syndrome 9.6
573 interstitial nephritis 9.6
574 portal hypertension 9.6
575 primary polycythemia 9.6
576 methemoglobinemia 9.6
577 gastric ulcer 9.6
578 hydrocephalus 9.6
579 discitis 9.6
580 hypoparathyroidism 9.6
581 vitamin k deficiency bleeding 9.6
582 pneumocystosis 9.6
583 spinal meningioma 9.6
584 heart disease 9.6
585 pyelonephritis 9.6
586 xanthogranulomatous pyelonephritis 9.6
587 mitral valve insufficiency 9.6
588 chondrocalcinosis 9.6
589 pericardium cancer 9.6
590 protein-energy malnutrition 9.6
591 cortical blindness 9.6
592 visual epilepsy 9.6
593 cryptococcosis 9.6
594 pulmonary alveolar proteinosis 9.6
595 primary biliary cirrhosis 9.6
596 graves' disease 9.6
597 hepatitis a 9.6
598 hepatic coma 9.6
599 hemolytic-uremic syndrome 9.6
600 hereditary hemorrhagic telangiectasia 9.6
601 guillain-barre syndrome 9.6
602 endomyocardial fibrosis 9.6
603 subleukemic leukemia 9.6
604 relapsing fever 9.6
605 acute cystitis 9.6
606 gout 9.6
607 brain cancer 9.6
608 right bundle branch block 9.6
609 pneumatosis cystoides intestinalis 9.6
610 exocrine pancreatic insufficiency 9.6
611 pure red-cell aplasia 9.6
612 hepatic encephalopathy 9.6
613 scleritis 9.6
614 tuberous sclerosis 9.6
615 eclampsia 9.6
616 obstructive jaundice 9.6
617 white piedra 9.6
618 autoimmune polyendocrine syndrome 9.6
619 azoospermia 9.6
620 ascending cholangitis 9.6
621 leopard syndrome 9.6
622 cerebral degeneration 9.6
623 papilledema 9.6
624 labyrinthitis 9.6
625 cystic echinococcosis 9.6
626 echinococcosis 9.6
627 ectropion 9.6
628 communicating hydrocephalus 9.6
629 rheumatic disease 9.6
630 mental depression 9.6
631 duodenal ulcer 9.6
632 cryptosporidiosis 9.6
633 squamous cell carcinoma 9.6
634 ocular melanoma 9.6
635 cheilitis 9.6
636 vascular disease 9.6
637 thyroid gland cancer 9.6
638 mononeuritis multiplex 9.6
639 malignant fibroxanthoma 9.6
640 gaucher's disease 9.6
641 fallopian tube carcinoma 9.6
642 rectum cancer 9.6
643 hyperinsulinism 9.6
644 enthesopathy 9.6
645 drug-induced hepatitis 9.6
646 ectodermal dysplasia 9.6
647 hemorrhagic disease 9.6
648 hidradenitis 9.6
649 dyspepsia 9.6
650 neonatal jaundice 9.6
651 wernicke encephalopathy 9.6
652 hemangioma 9.6
653 kidney cancer 9.6
654 capillary hemangioma 9.6
655 parasitic protozoa infectious disease 9.6
656 idiopathic interstitial pneumonia 9.6
657 nonspecific interstitial pneumonia 9.6
658 acalculous cholecystitis 9.6
659 hemoglobinopathy 9.6
660 endometrial adenocarcinoma 9.6
661 glomerulonephritis 9.6
662 newcastle disease 9.6
663 pulmonary tuberculosis 9.6
664 germ cell cancer 9.6
665 testicular cancer 9.6
666 grade iii astrocytoma 9.6
667 papillary carcinoma 9.6
668 acute porphyria 9.6
669 lipid metabolism disorder 9.6
670 oligodendroglioma 9.6
671 neurilemmoma 9.6
672 central nervous system lymphoma 9.6
673 embryonal rhabdomyosarcoma 9.6
674 subacute leukemia 9.6
675 thymoma 9.6
676 vaccinia 9.6
677 germinoma 9.6
678 teratocarcinoma 9.6
679 central nervous system disease 9.6
680 bone inflammation disease 9.6
681 mesenchymal cell neoplasm 9.6
682 fibrosarcoma 9.6
683 liposarcoma 9.6
684 breast disease 9.6
685 olfactory neuroblastoma 9.6
686 protein c deficiency 9.6
687 pulmonary fibrosis 9.6
688 pleural empyema 9.6
689 arthropathy 9.6
690 restrictive cardiomyopathy 9.6
691 ganglioneuroblastoma 9.6
692 mutism 9.6
693 hypertrichosis 9.6
694 myopathy 9.6
695 histiocytoma 9.6
696 polyradiculopathy 9.6
697 erdheim-chester disease 9.6
698 folliculitis 9.6
699 fibrous histiocytoma 9.6
700 seminoma 9.6
701 rhinitis 9.6
702 secretory meningioma 9.6
703 lymphoplasmacyte-rich meningioma 9.6
704 benign ependymoma 9.6
705 cerebellar astrocytoma 9.6
706 lymph node tuberculosis 9.6
707 thyroid gland disease 9.6
708 adjustment disorder 9.6
709 liver cirrhosis 9.6
710 ovarian cyst 9.6
711 sleep disorder 9.6
712 malignant teratoma 9.6
713 pediatric lymphoma 9.6
714 mitral valve disease 9.6
715 bronchitis 9.6
716 lymphopenia 9.6
717 reactive arthritis 9.6
718 acquired immunodeficiency syndrome 9.6
719 connective tissue disease 9.6
720 hepatoblastoma 9.6
721 thyroiditis 9.6
722 monoclonal gammopathy of uncertain significance 9.6
723 muscular atrophy 9.6
724 gastrointestinal system disease 9.6
725 placenta disease 9.6
726 end stage renal failure 9.6
727 retinal melanoma 9.6
728 paralytic ileus 9.6
729 intestinal volvulus 9.6
730 actinomycosis 9.6
731 chronic fatigue syndrome 9.6
732 malignant histiocytosis 9.6
733 nervous system disease 9.6
734 perinatal necrotizing enterocolitis 9.6
735 genital herpes 9.6
736 smallpox 9.6
737 crohn's disease 9.6
738 molluscum contagiosum 9.6
739 hard palate cancer 9.6
740 homocystinuria 9.6
741 splenic tuberculosis 9.6
742 epiglottitis 9.6
743 intracranial hypertension 9.6
744 fatty liver disease 9.6
745 noma 9.6
746 hemorrhoid 9.6
747 miliary tuberculosis 9.6
748 hemophilia 9.6
749 triple x syndrome 9.6
750 familial monosomy 7 syndrome 9.6
751 ltbp4-related cutis laxa 9.6
752 samd9l-related ataxia-pancytopenia syndrome 9.6
753 sickle cell disease 9.6
754 47, xxy 9.6
755 acute panmyelosis with myelofibrosis 9.6
756 afibrinogenemia 9.6
757 al amyloidosis 9.6
758 aminoaciduria 9.6
759 aml with myelodysplasia-related features 9.6
760 anaplastic oligodendroglioma 9.6
761 anterior uveitis 9.6
762 aspergillus niger infection 9.6
763 carotidynia 9.6
764 central congenital hypothyroidism 9.6
765 chromosome 12q duplication 9.6
766 chromosome 13q duplication 9.6
767 chromosome 16 trisomy 9.6
768 chromosome 21q duplication 9.6
769 clostridium septicum infection 9.6
770 congenital hydrocephalus 9.6
771 cytochrome p450 2d6 variant 9.6
772 cytomegalic inclusion disease 9.6
773 enterovesical fistula 9.6
774 ependymoma 9.6
775 ewing's family of tumors 9.6
776 gigantism 9.6
777 heparin-induced thrombocytopenia 9.6
778 hereditary methemoglobinemia 9.6
779 hhv-6 encephalitis 9.6
780 hypothalamic obesity 9.6
781 inherited bone marrow failure syndromes 9.6
782 lymphomatoid granulomatosis 9.6
783 marek disease 9.6
784 mycetoma 9.6
785 myeloid splenomegaly 9.6
786 oncogenic osteomalacia 9.6
787 oral cancer 9.6
788 pilocytic astrocytoma 9.6
789 polymorphic reticulosis 9.6
790 polymyositis 9.6
791 post-transplant lymphoproliferative disease 9.6
792 primary biliary cholangitis 9.6
793 primary central nervous system lymphoma 9.6
794 pseudo-turner syndrome 9.6
795 pure autonomic failure 9.6
796 retroperitoneal fibrosis 9.6
797 reversible cerebral vasoconstriction syndrome 9.6
798 rhizomelic pseudopolyarthritis 9.6
799 ring chromosome 1 9.6
800 soft tissue sarcoma 9.6
801 stenotrophomonas maltophilia infection 9.6
802 stevens-johnson syndrome/toxic epidermal necrolysis 9.6
803 thiopurine s methyltranferase deficiency 9.6
804 thrombasthenia 9.6
805 triploidy 9.6
806 trisomy 22 9.6
807 undifferentiated pleomorphic sarcoma 9.6
808 weber syndrome 9.6
809 angiomatosis 9.6
810 dysphagia 9.6
811 pituitary tumors 9.6
812 seizure disorder 9.6
813 spinal cord injury 9.6
814 b-cell non-hodgkin lymphoma 9.6
815 t-cell non-hodgkin lymphoma 9.6
816 rare neurodegenerative disease 9.6
817 rapidly involuting congenital hemangioma 9.6
818 partial deletion of the long arm of chromosome 5 9.6
819 partial deletion of the long arm of chromosome 6 9.6
820 complex chromosomal rearrangement 9.6
821 bone sarcoma 9.6
822 idiopathic hypercalciuria 9.6
823 lymphomatous meningitis 9.6
824 ring chromosome 9.6
825 gonadal germ cell tumor 9.6
826 acquired methemoglobinemia 9.6
827 scedosporiosis 9.6
828 osteonecrosis of the jaw 9.6
829 primary lymphedema 9.6
830 maternal uniparental disomy 9.6
831 monosomy 22 9.6
832 acute myeloid leukemia with 11q23 abnormalities 9.6
833 hereditary optic neuropathy 9.6
834 aregenerative anemia 9.6
835 eosinophilic granuloma 9.6
836 bone marrow cancer 9.3 RUNX1 MPO KMT2A KIT JAK2 FLT3

Comorbidity relations with Acute Leukemia via Phenotypic Disease Network (PDN): (showing 2, show less)


Deficiency Anemia Neutropenia

Graphical network of the top 20 diseases related to Acute Leukemia:



Diseases related to Acute Leukemia

Symptoms & Phenotypes for Acute Leukemia

GenomeRNAi Phenotypes related to Acute Leukemia according to GeneCards Suite gene sharing:

26 (showing 1, show less)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 9.92 AFF1 ANPEP BAALC CEBPA CREBBP CSF3

MGI Mouse Phenotypes related to Acute Leukemia:

46 (showing 15, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.4 AFF1 ANPEP CEBPA CREBBP CSF3 DNTT
2 immune system MP:0005387 10.36 AFF1 ANPEP CEBPA CREBBP CSF3 DNTT
3 growth/size/body region MP:0005378 10.32 AFF1 CEBPA CREBBP ETV6 FLT3 JAK2
4 homeostasis/metabolism MP:0005376 10.29 CEBPA CREBBP DNTT ETV6 FLT3 JAK2
5 cardiovascular system MP:0005385 10.25 ANPEP CEBPA CREBBP ETV6 KIT KMT2A
6 endocrine/exocrine gland MP:0005379 10.22 AFF1 ANPEP CEBPA CREBBP ETV6 FLT3
7 mortality/aging MP:0010768 10.21 AFF1 CEBPA CREBBP ETV6 FLT3 JAK2
8 embryo MP:0005380 10.14 CREBBP ETV6 JAK2 KIT KMT2A MLLT3
9 integument MP:0010771 10.13 ANPEP CEBPA CREBBP CSF3 ETV6 JAK2
10 liver/biliary system MP:0005370 10.01 CEBPA CREBBP JAK2 KIT KMT2A MTHFR
11 neoplasm MP:0002006 10 CEBPA CREBBP ETV6 FLT3 JAK2 KIT
12 muscle MP:0005369 9.87 CEBPA CREBBP KIT KMT2A MPO STMN1
13 no phenotypic analysis MP:0003012 9.85 AFF1 CEBPA ETV6 FLT3 KIT KMT2A
14 normal MP:0002873 9.7 CEBPA CREBBP DNTT ETV6 JAK2 KIT
15 skeleton MP:0005390 9.28 CREBBP FLT3 JAK2 KIT KMT2A MLLT3

Drugs & Therapeutics for Acute Leukemia

Drugs for Acute Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 465, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Arsenic trioxide Approved, Investigational Phase 4 1327-53-3 518740
2
Micafungin Approved, Investigational Phase 4 235114-32-6 3081921 477468
3
Etoposide Approved Phase 4 33419-42-0 36462
4
Mercaptopurine Approved Phase 4 50-44-2 667490
5
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
6
Vincristine Approved, Investigational Phase 4 57-22-7, 2068-78-2 5978
7
Daunorubicin Approved Phase 4 20830-81-3 30323
8
Lenograstim Approved, Investigational Phase 4 135968-09-1
9
Amphotericin B Approved, Investigational Phase 4 1397-89-3 14956 5280965
10
Sargramostim Approved, Investigational Phase 4 83869-56-1, 123774-72-1
11 glucocorticoids Phase 4
12 Anti-Inflammatory Agents Phase 4
13 Antineoplastic Agents, Phytogenic Phase 4
14 Tubulin Modulators Phase 4
15 Antimitotic Agents Phase 4
16 Etoposide phosphate Phase 4
17 Hormone Antagonists Phase 4
18 Hormones Phase 4
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
20 Mitogens Phase 4
21 Liposomal amphotericin B Phase 4
22 Antiparasitic Agents Phase 4
23 Antiprotozoal Agents Phase 4
24 14-alpha Demethylase Inhibitors Phase 4
25 Cytochrome P-450 CYP3A Inhibitors Phase 4
26 Cytochrome P-450 Enzyme Inhibitors Phase 4
27 Steroid Synthesis Inhibitors Phase 4
28 Adjuvants, Immunologic Phase 4
29 Cytochrome P-450 CYP2C9 Inhibitors Phase 4
30
Ketamine Approved, Vet_approved Phase 3 6740-88-1 3821
31
Vindesine Approved, Investigational Phase 3 59917-39-4, 53643-48-4 40839
32
Oprelvekin Approved, Investigational Phase 2, Phase 3 145941-26-0
33 Clove Approved Phase 2, Phase 3
34
Morphine Approved, Investigational Phase 3 57-27-2 5288826
35
Dalteparin Approved Phase 3 9005-49-6
36
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
37
Ofloxacin Approved Phase 3 82419-36-1 4583
38
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
39
Darbepoetin alfa Approved, Investigational Phase 3 11096-26-7, 209810-58-2
40
Pentostatin Approved, Investigational Phase 3 53910-25-1 40926 439693
41
Chlorambucil Approved Phase 3 305-03-3 2708
42
Adenosine Approved, Investigational Phase 3 58-61-7 60961
43
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
44
Procarbazine Approved, Investigational Phase 3 671-16-9 4915
45
Vinblastine Approved Phase 3 865-21-4 241903 13342
46
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
47
Dacarbazine Approved, Investigational Phase 3 4342-03-4 5351166
48
Irinotecan Approved, Investigational Phase 3 100286-90-6, 97682-44-5 60838
49
Rasburicase Approved, Investigational Phase 2, Phase 3 134774-45-1
50
Acetylcysteine Approved, Investigational Phase 3 616-91-1 12035
51
Lomustine Approved, Investigational Phase 2, Phase 3 13010-47-4 3950
52
Lorazepam Approved Phase 3 846-49-1 3958
53
Loperamide Approved Phase 3 53179-11-6 3955
54
Carboplatin Approved Phase 2, Phase 3 41575-94-4 10339178 498142 38904
55
Lenalidomide Approved Phase 3 191732-72-6 216326
56
Sodium citrate Approved, Investigational Phase 3 68-04-2
57
Hydroxyurea Approved Phase 3 127-07-1 3657
58
Mesna Approved, Investigational Phase 3 3375-50-6 598
59
Peginterferon alfa-2b Approved Phase 3 99210-65-8, 215647-85-1
60
Peginterferon alfa-2a Approved, Investigational Phase 3 198153-51-4 5360545
61
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
62
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
63
Pegaspargase Approved, Investigational Phase 3 130167-69-0
64
Thioguanine Approved Phase 3 154-42-7 2723601
65
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
66
Hydrocortisone acetate Approved, Vet_approved Phase 3 50-03-3
67
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703