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MCID: ACT134
MIFTS: 53

Acute Liver Failure

Categories: Blood diseases, Endocrine diseases, Gastrointestinal diseases, Genetic diseases, Liver diseases, Metabolic diseases, Nephrological diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Acute Liver Failure

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MalaCards integrated aliases for Acute Liver Failure:

Name: Acute Liver Failure 39 60 56
Fulminant Hepatic Failure 60 38 30
Acute Hepatic Failure 60 6
Hepatic Failure Fulminant 56
Liver Failure, Acute 74
Liver Failure Acute 56

Characteristics:

Orphanet epidemiological data:

60
acute liver failure
Prevalence: 1-5/10000 (Europe);

Classifications:

MalaCards categories:
Global: Rare diseases Metabolic diseases Genetic diseases
Anatomical: Liver diseases Blood diseases Nephrological diseases Gastrointestinal diseases Endocrine diseases
See all MalaCards categories (disease lists)
ICD10: 35
Orphanet: 60  
Rare hepatic diseases


External Ids:

KEGG 38 H01712
MESH via Orphanet 46 D017114
ICD10 via Orphanet 35 K72.0
UMLS via Orphanet 75 C0162557
Orphanet 60 ORPHA90062
UMLS 74 C0162557
Sources

Summaries for Acute Liver Failure

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MalaCards based summary : Acute Liver Failure, also known as fulminant hepatic failure, is related to infantile liver failure syndrome 1 and hepatitis. An important gene associated with Acute Liver Failure is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways is FOXA2 and FOXA3 transcription factor networks. The drugs Acetylcysteine and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include Liver, liver and brain.

Wikipedia : 77 Acute liver failure is the appearance of severe complications rapidly after the first signs of liver... more...

Sources

Related Diseases for Acute Liver Failure

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Diseases in the Liver Disease family:

Liver Failure, Infantile, Transient Infantile Liver Failure Syndrome 1
Infantile Liver Failure Syndrome 2 Acute Liver Failure

Diseases related to Acute Liver Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 368)
# Related Disease Score Top Affiliating Genes
1 infantile liver failure syndrome 1 32.4 ALB F2 GPT SLC17A5
2 hepatitis 32.4 F2 GPT SLC17A5
3 hepatitis e 30.6 ALB F2 GPT
4 hepatitis a 30.4 ALB F2 GPT
5 intracranial hypertension 30.4 F2 F5
6 wilson disease 30.4 ALB F2 GPT
7 scrub typhus 30.3 GPT SLC17A5
8 hepatitis b 30.3 ALB F2 GPT SLC17A5
9 typhoid fever 30.1 ALB F2
10 viral hepatitis 30.0 ALB F2 GPT SLC17A5
11 dengue hemorrhagic fever 30.0 ALB F2
12 hepatic coma 30.0 ALB F2 GPT TSPO
13 hemorrhagic fever 29.9 ALB F2 GPT
14 fatty liver disease, nonalcoholic 1 29.9 GPT SLC17A5
15 portal hypertension 29.8 ALB F2 GPT
16 non-a-e hepatitis 29.8 ALB F2
17 cryptogenic cirrhosis 29.8 F2 F5
18 hepatorenal syndrome 29.7 ALB F2
19 liver disease 29.7 ALB F2 GPT HGF SLC17A5
20 nonalcoholic steatohepatitis 29.7 F2 GPT SLC17A5
21 biliary atresia 29.5 ALB GPT HGF
22 obstructive nephropathy 29.5 ALB HGF
23 protein s deficiency 29.5 F2 F5
24 hepatic tuberculosis 29.5 ALB F2 GPT
25 cholecystitis 29.5 ALB F2 GPT
26 paracetamol poisoning 29.5 F2 F5 GC
27 cholangitis 29.5 ALB F2 GPT
28 compartment syndrome 29.4 ALB F2 SLC17A5
29 factor x deficiency 29.4 F2 F5
30 disseminated intravascular coagulation 29.3 F2 F5
31 hepatic encephalopathy 29.3 ALB F2 GC GPT SLC17A5 TSPO
32 bilirubin metabolic disorder 29.1 ALB F2 GPT SLC17A5
33 alcoholic hepatitis 29.1 ALB F2 GPT SLC17A5
34 liver cirrhosis 29.1 ALB F2 GPT HGF SLC17A5
35 pulmonary embolism 29.1 ALB F2 F5
36 liver failure, infantile, transient 11.6
37 epiphyseal dysplasia, multiple, with early-onset diabetes mellitus 11.5
38 ruijs-aalfs syndrome 11.2
39 mpv17-related hepatocerebral mitochondrial dna depletion syndrome 11.2
40 infantile liver failure syndrome 2 11.2
41 mitochondrial dna depletion syndrome 4a 11.0
42 encephalopathy 10.5
43 brain edema 10.4
44 lymphoma 10.4
45 hepatoportal sclerosis 10.3 F2 GPT
46 hepatitis d 10.3 F2 GPT
47 paraquat poisoning 10.3 GPT SLC17A5
48 pyridoxine deficiency 10.3 GPT SLC17A5
49 hemophagocytic lymphohistiocytosis 10.3
50 herpes simplex 10.3

Graphical network of the top 20 diseases related to Acute Liver Failure:



Diseases related to Acute Liver Failure
Sources

Symptoms & Phenotypes for Acute Liver Failure

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Sources

Drugs & Therapeutics for Acute Liver Failure

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Drugs for Acute Liver Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 218)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcysteine Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 616-91-1 12035
2
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
5
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
6
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
7
Pantoprazole Approved Phase 4 102625-70-7 4679
8
Haloperidol Approved Phase 4 52-86-8 3559
9
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
10
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
11 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
12 Gastrointestinal Agents Phase 4,Not Applicable
13 Protective Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
14 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
15 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
16 Antiviral Agents Phase 4,Phase 3,Phase 1,Not Applicable
17 Anti-Ulcer Agents Phase 4,Not Applicable
18 Antacids Phase 4,Not Applicable
19 Neurotransmitter Agents Phase 4,Phase 2,Not Applicable
20 Expectorants Phase 4,Phase 3,Phase 1,Not Applicable
21 N-monoacetylcystine Phase 4,Phase 3,Phase 1,Not Applicable
22 Antidotes Phase 4,Phase 3,Phase 1,Not Applicable
23 Antioxidants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
24 Free Radical Scavengers Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
25 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Not Applicable
26 Respiratory System Agents Phase 4,Phase 3,Phase 1,Not Applicable
27 Anti-Bacterial Agents Phase 4,Phase 2,Phase 1,Not Applicable
28 Antiemetics Phase 4
29 Methylprednisolone Acetate Phase 4
30 Antineoplastic Agents, Hormonal Phase 4
31 Hormone Antagonists Phase 4
32 Neuroprotective Agents Phase 4
33 glucocorticoids Phase 4
34 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
35 Prednisolone acetate Phase 4
36 Anti-Inflammatory Agents Phase 4,Not Applicable
37 Hormones Phase 4
38 Autonomic Agents Phase 4,Not Applicable
39 Anti-HIV Agents Phase 4
40 Nucleic Acid Synthesis Inhibitors Phase 4
41 Anti-Retroviral Agents Phase 4
42 Reverse Transcriptase Inhibitors Phase 4
43 Proton Pump Inhibitors Phase 4
44 Haloperidol decanoate Phase 4
45 Antipsychotic Agents Phase 4
46 Dopamine Antagonists Phase 4
47 Tranquilizing Agents Phase 4
48 Psychotropic Drugs Phase 4
49 Dopamine Agents Phase 4
50 Central Nervous System Depressants Phase 4

Interventional clinical trials:

(show top 50) (show all 92)
# Name Status NCT ID Phase Drugs
1 Assessment of Coagulation Abnormalities in Acute on Chronic Liver Failure Patients Using Thromboelastography Unknown status NCT02757170 Phase 4
2 Steroids in Fulminant Hepatitis A in the Pediatric Age Group Completed NCT02375867 Phase 4 prednisolone;methylprednisolone
3 A Randomized Controlled Trial of Lamivudine in Acute Hepatitis B Completed NCT00380614 Phase 4 Lamivudine
4 Liver Function After Intravenous Methylprednisolone Administration Completed NCT03667157 Phase 4 every week IVMP therapy;very high doses IVMP therapy
5 Stress Ulcer Prophylaxis in the Intensive Care Unit Completed NCT02467621 Phase 4 Pantoprazole
6 Agents Intervening Against Delirium in Intensive Care Unit Recruiting NCT03392376 Phase 4 Haloperidol Injection
7 Study of N-Acetylcysteine in Acute Liver Failure (ALF) Terminated NCT00896025 Phase 4 N-acetylcysteine
8 Minocycline Administration During Human Liver Transplantation Withdrawn NCT02712775 Phase 4 Minocycline (yes/no);Placebo
9 N-acetylcysteine in Non-Acetaminophen Pediatric Acute Liver Failure Completed NCT00248625 Phase 3 N-acetylcysteine;Placebo
10 Randomized Study of Acetylcysteine in Patients With Acute Liver Failure Not Caused by Acetaminophen Completed NCT00004467 Phase 3 N-acetylcysteine (NAC);Placebo
11 The MARS® Albumin Dialysis System in Patients With Fulminant and Subfulminant Hepatic Failure Completed NCT00224705 Phase 3
12 MK-0524B Lipid Study (MK-0524B-063) Completed NCT00479882 Phase 3 Comparator: simvastatin;MK-0524A;Placebo;MK-0524B
13 Lipid Efficacy and Safety in Participants With Mixed Hyperlipidemia (MK-0524B-024) Completed NCT00289900 Phase 3 MK-0524A;Atorvastatin;Simvastatin
14 13C-Methacetin Breath Test for the Prediction of Outcome in in ALI or ALF Recruiting NCT02786836 Phase 2, Phase 3 13C-Methacetin
15 To Assess Safety/Efficacy of ELAD in Subjects w/ Severe Acute Alcoholic Hepatitis (sAAH) and Lille Score Failure Terminated NCT01829347 Phase 3
16 A Study to Evaluate Efficacy and Safety of Extended-Release Niacin + Laropiprant + Simvastatin in Participants With Primary Hypercholesterolemia or Mixed Dyslipidemia (MK-0524B-118) Terminated NCT01294683 Phase 3 Simvastatin;Extended Release (ER) niacin/laropiprant/simvastatin (N/LRPT/SIM);Extended Release (ER) niacin/laropiprant (N/LRPT);Placebo
17 Registry Protocol for Tracking Trial Subjects After VTI-206 Study Completion Withdrawn NCT01452295 Phase 2, Phase 3 ELAD (Extracorporeal Liver Assist System)
18 Cardiox Liver Function Test Pivotal Trial Withdrawn NCT02552901 Phase 3 0.1 mg/kg ICG Dose;0.5 mg/kg ICG dose
19 Therapeutic Efficacy of L-Ornithine L-Aspartate Infusion in Patients With Acute Liver Failure Unknown status NCT00470314 Phase 2 L-Ornithine L-Aspartate
20 Efficacy & Safety of ALF-5755 in Patients With Nonacetaminophen Severe Acute Hepatitis & Early Stage Acute Liver Failure Unknown status NCT01318525 Phase 2 ALF-5755;Saline solution (0.9% NaCl)
21 Phase I/II Study of Recombinant Human Hepatocyte Growth Factor in Fulminant Hepatic Failure Unknown status NCT00225901 Phase 1, Phase 2 Recombinant human hepatocyte growth factor
22 Molecular Adsorbent Recirculating System (MARS®) in Hypoxic Hepatitis Unknown status NCT01690845 Phase 2
23 Mesenchymal Stem Cells After Renal or Liver Transplantation Unknown status NCT01429038 Phase 1, Phase 2
24 Safety Study of Ornithine Phenylacetate to Treat Patients With Acute Liver Failure/Severe Acute Liver Injury Completed NCT01548690 Phase 2 Ornithine Phenylacetate
25 Emergency Use of OCR-002 in Acute Liver Failure Completed NCT01634230 Phase 2 OCR-002
26 Phase 2 Evaluation of the ELAD System in the Management of Acute Liver Failure Completed NCT00030225 Phase 2
27 Safety & Efficacy of the Extracorporeal Liver Assist Device (ELAD) System in Patients With Hepatic Insufficiency Completed NCT00771446 Phase 1, Phase 2
28 Study to Evaluate Safety and Efficacy of LifeLiver in Acute or Acute-on-Chronic Liver Failure Patients Not yet recruiting NCT03882346 Phase 2
29 Safety and Efficacy of the ELAD System (ELAD) to Treat Acute Liver Failure (ALF) Terminated NCT01875874 Phase 2
30 Pharmacokinetic and Pharmacodynamic Study of IDN-6556 in ACLF Terminated NCT01937130 Phase 2 IDN-6556
31 Safety and Efficacy of the Extracorporeal Liver Assist Device (ELAD®) In Patients With Fulminant Hepatic Failure (FHF) Withdrawn NCT00832728 Phase 2
32 Hepatocyte Transplantation in Liver Failure Withdrawn NCT00805610 Phase 1, Phase 2
33 Macrophage Markers, Soluble CD163 (sCD163) and Soluble CD206 (sCD206) in Paracetamol Overdose Completed NCT03679442 Phase 1 N-acetylcysteine
34 A Study to Evaluate the Pharmacokinetics of Acetaminophen and Its Toxic Metabolites With 2 Formulations (Panadol and SafeTynadol) in Healthy Volunteers Completed NCT03451487 Phase 1 Panadol®;SafeTynadol®
35 Safety Study of Stemchymal® in Acute Liver Failure Not yet recruiting NCT03629015 Phase 1
36 A Phase 1 Study of LJPC-501 in Patients With Hepatorenal Syndrome Terminated NCT01906307 Phase 1 LJPC-501
37 Hepatocyte Transplantation for Acute Decompensated Liver Failure Withdrawn NCT01345565 Phase 1 human hepatocytes
38 Granulocyte Colony Stimulating Factor (G-CSF) in Acute Liver Failure and Alcoholic Hepatitis Unknown status NCT01341951 Not Applicable Granulocyte colony stimulating factor
39 Growth Factors and Hepatic Progenitor Cells in Acute Liver Failure Unknown status NCT01312220
40 Breath Test for Patients With Acute Liver Disease for Early Detection of the Need for Transplant or Recovery Unknown status NCT01435421
41 Removal of Protein Bound Uremic Toxins by Modified Plasma Separation and Adsorption Combined With Hemodialysis Unknown status NCT00375635 Not Applicable
42 Clinical and Basic Research of ETV Plus GM-CSF in Chronic Hepatitis B Patients Unknown status NCT03164889 Not Applicable Granulocyte Macrophage-colony Stimulating Factor;Entecavir
43 Evolution and Clinical Outcomes in Patients Undergoing Liver Transplantation Unknown status NCT02917382
44 Mechanisms of N-acetylcysteine Mediated Vascular Adverse Effects Unknown status NCT01209455 Not Applicable Chlorphenamine and Ranitidine;Paracetamol;Paracetamol
45 Oxidative Stress and Microcirculation in Patient With Hepatic Failure Undergoing Liver Support Treatment Unknown status NCT00772252
46 Hepatitis B Antigen Kidney Graft Into Protective Level Hepatitis B Antibody Recipients Unknown status NCT02044588
47 Evaluation of Mechanisms Responsible for Coma in Patients Affected by Fulminant, Acute and Chronic Hepatic Failure Unknown status NCT01582087
48 Clinical and Basic Study for Pediatric Liver Transplantation Unknown status NCT02503384
49 High Volume Plasma Exchange in Children With Acute Liver Failure and Acute on Chronic Liver Failure Completed NCT02719210 Not Applicable Hypertonic 3% saline;Mannitol
50 A Multi-Center Group to Study Acute Liver Failure in Children Completed NCT00986648

Search NIH Clinical Center for Acute Liver Failure

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Acute Liver Failure cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Acute Liver Failure:
Hepatocyte transplantation for treatment of liver disorders
Hepatocyte transplantation for treatment of liver failure and inherited metabolic diseases
Liver cells for liver diseases
Embryonic/Adult Cultured Cells Related to Acute Liver Failure:
Hepatocytes PMIDs: 15239608 12777539 9580649 22789058 22167636
Liver cells PMIDs: 22532025 19295306 19796496 16454359 17060866
Sources

Genetic Tests for Acute Liver Failure

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Genetic tests related to Acute Liver Failure:

# Genetic test Affiliating Genes
1 Fulminant Hepatic Failure 30
Sources

Anatomical Context for Acute Liver Failure

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MalaCards organs/tissues related to Acute Liver Failure:

42
Liver, Brain, Testes, Bone, Bone Marrow, Lung, Kidney
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Acute Liver Failure:
# Tissue Anatomical CompartmentCell Relevance
1 Liver Liver Lobule Hepatocytes Affected by disease, potential therapeutic candidate
Sources

Publications for Acute Liver Failure

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Articles related to Acute Liver Failure:

(show top 50) (show all 3746)
# Title Authors Year
1
Human genomics of acute liver failure due to hepatitis B virus infection: An exome sequencing study in liver transplant recipients. ( 30315682 )
2019
2
Acute liver failure: A review for emergency physicians. ( 30414744 )
2019
3
A20 rescues hepatocytes from apoptosis through the NF-κB signaling pathway in rats with acute liver failure. ( 30446523 )
2019
4
Neonatal acute liver failure due to enteroviruses: a 14 years single NICU experience. ( 30513031 )
2019
5
Novel neuroblastoma amplified sequence (NBAS) mutations in a Japanese boy with fever-triggered recurrent acute liver failure. ( 30622725 )
2019
6
Acute liver failure: Running fast between the traps. ( 30635100 )
2019
7
Hepatoprotective effects and structure-activity relationship of five flavonoids against lipopolysaccharide/d-galactosamine induced acute liver failure in mice. ( 30641432 )
2019
8
Behavioral, neurochemical and brain oscillation abnormalities in an experimental model of acute liver failure. ( 30654003 )
2019
9
Dysregulated activation of fetal liver programme in acute liver failure. ( 30670575 )
2019
10
The incidence, etiologies, outcomes, and predictors of mortality of acute liver failure in Thailand: a population-base study. ( 30691414 )
2019
11
Update on the management of acute liver failure. ( 30694840 )
2019
12
Therapeutic potential of plasma proteins derived from umbilical cord blood for acute liver failure. ( 30698974 )
2019
13
Mutation in ITCH Gene Can Cause Syndromic Multisystem Autoimmune Disease With Acute Liver Failure. ( 30705142 )
2019
14
The antagonistic effect of tamoxifen against d-galactosamine/lipopolysaccharide-induced acute liver failure is associated with reactivation of hepatic nuclear factor-κB. ( 30721100 )
2019
15
Acetaminophen is Undetectable in Plasma From More Than Half of Patients Believed to Have Acute Liver Failure Due to Overdose. ( 30731196 )
2019
16
Intracranial Pressure Evaluation in Acute Liver Failure. ( 30734243 )
2019
17
Acute liver failure increases kynurenic acid production in rat brain via changes in tryptophan metabolism in the periphery. ( 30738081 )
2019
18
Correction: Cytokine profiles in acute liver injury-Results from the US Drug-Induced Liver Injury Network (DILIN) and the Acute Liver Failure Study Group. ( 30742679 )
2019
19
Author's Response to Letter to the Editor: Noninvasive Intracranial Pressure Assessment in Acute Liver Failure. ( 30756317 )
2019
20
Neurological Recovery After Recovery From Acute Liver Failure: Is it Complete? ( 30765942 )
2019
21
Drug-induced idiosyncratic acute liver failure: A challenging and distressing scenario. ( 30767751 )
2019
22
Corticosteroid Therapy for Indeterminate Pediatric Acute Liver Failure and Aplastic Anemia with Acute Hepatitis. ( 30770193 )
2019
23
Obeticholic acid differentially regulates hepatic injury and inflammation at different stages of D-galactosamine/lipopolysaccharide-evoked acute liver failure. ( 30772394 )
2019
24
Quantitative real-time PCR for differential diagnostics of parvovirus B19 infection in acute liver failure patients. ( 30773069 )
2019
25
Acute liver failure caused by occupational exposure to HCFC-123: Two case reports. ( 30817569 )
2019
26
Down-regulation of miR-122 after transplantation of mesenchymal stem cells in acute liver failure in mice model. ( 30824230 )
2019
27
Host Genetic Variant in CXCL16 May Be Associated With Hepatitis B Virus-Related Acute Liver Failure. ( 30827414 )
2019
28
Extracorporeal Liver Support in Patients with Acute Liver Failure. ( 30833847 )
2019
29
Recurrent acute liver failure associated with novel SCYL1 mutation: A case report. ( 30842961 )
2019
30
Live donor liver transplantation for acute liver failure - Donor safety and recipient outcome. ( 30861306 )
2019
31
Peripheral infusion of human umbilical cord mesenchymal stem cells rescues acute liver failure lethality in monkeys. ( 30867056 )
2019
32
rhIL-1Ra reduces hepatocellular apoptosis in mice with acute liver failure mainly by inhibiting the activities of Kupffer cells. ( 30902658 )
2019
33
An Unusual Case of Acute Liver Failure Caused by Adjuvant Oral Tegafur-Uracil with Folinate Therapy for Colon Cancer Patient: a Case Report. ( 30903577 )
2019
34
Successful Treatment of a South African Pediatric Case of Acute Liver Failure Caused by Perinatal Transmission of Hepatitis B. ( 29601455 )
2019
35
Tectorigenin protects against experimental fulminant hepatic failure by regulating the TLR4/mitogen-activated protein kinase and TLR4/nuclear factor-κB pathways and autophagy. ( 30701601 )
2019
36
Neutralization of CD95 ligand protects the liver against ischemia-reperfusion injury and prevents acute liver failure. ( 29374146 )
2018
37
Absolute quantitation of acetaminophen-modified human serum albumin in acute liver failure patients by LC-MS/MS. ( 29920820 )
2018
38
Challenges in the early diagnosis of patients with acute liver failure induced by amatoxin poisoning: Two case reports. ( 29979397 )
2018
39
Human liver organoids generated with single donor-derived multiple cells rescue mice from acute liver failure. ( 29321049 )
2018
40
Mesenchymal Stem Cell/Red Blood Cell-Inspired Nanoparticle Therapy in Mice with Carbon Tetrachloride-Induced Acute Liver Failure. ( 29943967 )
2018
41
Hepatitis A, cardiomyopathy, aplastic anemia, and acute liver failure: A devastating scenario. ( 29359844 )
2018
42
Acute Liver Failure due to Amanita phalloides Poisoning: Therapeutic Approach and Outcome. ( 29407307 )
2018
43
Acute Liver Failure of Indeterminate Etiology: A Comprehensive Systematic Approach by An Expert Committee to Establish Causality. ( 29946176 )
2018
44
Beyond KCH selection and options in acute liver failure. ( 29858744 )
2018
45
Liver transplantation for acute liver failure - a 30-year single center experience. ( 29848142 )
2018
46
Drug idiosyncrasy due to pirfenidone presenting as acute liver failure: Case report and mini-review of the literature. ( 29404521 )
2018
47
Case Report of Isoniazid-Related Acute Liver Failure Requiring Liver Transplantation. ( 29783726 )
2018
48
Acute Liver Failure in an Adolescent Male Induced by Human Herpesvirus 6 (HHV-6): A Case Report With Literature Review. ( 29390152 )
2018
49
Protective effect of Coptisine from Rhizoma Coptidis on LPS/D-GalN-induced acute liver failure in mice through up-regulating expression of miR-122. ( 29253766 )
2018
50
Acute liver failure due to liver parenchymal infiltration with acute myelogenous leukaemia in a patient with myelodysplastic syndrome. ( 29954762 )
2018
Sources

Variations for Acute Liver Failure

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ClinVar genetic disease variations for Acute Liver Failure:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 POLG2 NM_007215.3(POLG2): c.544C> T (p.Arg182Trp) single nucleotide variant Likely pathogenic rs886037843 GRCh37 Chromosome 17, 62492543: 62492543
2 POLG2 NM_007215.3(POLG2): c.544C> T (p.Arg182Trp) single nucleotide variant Likely pathogenic rs886037843 GRCh38 Chromosome 17, 64496425: 64496425
3 MT-CO3 NC_012920.1: m.9355A> T single nucleotide variant Uncertain significance rs1556423663 GRCh37 Chromosome MT, 9355: 9355
4 MT-CO3 NC_012920.1: m.9355A> T single nucleotide variant Uncertain significance rs1556423663 GRCh38 Chromosome MT, 9355: 9355
Sources

Expression for Acute Liver Failure

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Search GEO for disease gene expression data for Acute Liver Failure.
Sources

Pathways for Acute Liver Failure

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Pathways related to Acute Liver Failure according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
FOXA2 and FOXA3 transcription factor networks 1
10.27 ALB F2
Sources

GO Terms for Acute Liver Failure

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Cellular components related to Acute Liver Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.43 ALB F2 F5
2 extracellular space GO:0005615 9.43 ALB F2 F5 GC GPT HGF
3 blood microparticle GO:0072562 9.33 ALB F2 GC
4 platelet alpha granule lumen GO:0031093 8.8 ALB F5 HGF

Biological processes related to Acute Liver Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.43 ALB F2 F5
2 hemostasis GO:0007599 9.32 F2 F5
3 positive regulation of reactive oxygen species metabolic process GO:2000379 9.16 F2 TSPO
4 anion transport GO:0006820 8.96 SLC17A5 TSPO
5 platelet degranulation GO:0002576 8.8 ALB F5 HGF

Molecular functions related to Acute Liver Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pyridoxal phosphate binding GO:0030170 8.62 ALB GPT
Sources

Sources for Acute Liver Failure

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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