Acute Liver Failure

Categories: Blood diseases, Endocrine diseases, Gastrointestinal diseases, Genetic diseases, Liver diseases, Metabolic diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Acute Liver Failure

MalaCards integrated aliases for Acute Liver Failure:

Name: Acute Liver Failure 39 60 56
Fulminant Hepatic Failure 60 38 30
Acute Hepatic Failure 60 6
Hepatic Failure Fulminant 56
Liver Failure, Acute 74
Liver Failure Acute 56


Orphanet epidemiological data:

acute liver failure
Prevalence: 1-5/10000 (Europe);


Orphanet: 60  
Rare hepatic diseases

External Ids:

KEGG 38 H01712
MESH via Orphanet 46 D017114
ICD10 via Orphanet 35 K72.0
UMLS via Orphanet 75 C0162557
Orphanet 60 ORPHA90062
UMLS 74 C0162557

Summaries for Acute Liver Failure

MalaCards based summary : Acute Liver Failure, also known as fulminant hepatic failure, is related to infantile liver failure syndrome 1 and hepatitis. An important gene associated with Acute Liver Failure is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways is FOXA2 and FOXA3 transcription factor networks. The drugs Acetylcysteine and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include Liver, liver and brain.

Wikipedia : 77 Acute liver failure is the appearance of severe complications rapidly after the first signs of liver... more...

Related Diseases for Acute Liver Failure

Diseases in the Liver Disease family:

Liver Failure, Infantile, Transient Infantile Liver Failure Syndrome 1
Infantile Liver Failure Syndrome 2 Acute Liver Failure

Diseases related to Acute Liver Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 386)
# Related Disease Score Top Affiliating Genes
1 infantile liver failure syndrome 1 32.5 ALB F2 GPT SLC17A5
2 hepatitis 32.4 F2 GPT SLC17A5
3 hepatitis e 30.6 ALB F2 GPT
4 hepatitis a 30.5 ALB F2 GPT
5 intracranial hypertension 30.4 F2 F5
6 wilson disease 30.4 ALB F2 GPT
7 scrub typhus 30.3 GPT SLC17A5
8 hepatitis b 30.3 ALB F2 GPT SLC17A5
9 hepatic coma 30.1 ALB F2 GPT TSPO
10 typhoid fever 30.1 ALB F2
11 viral hepatitis 30.1 ALB F2 GPT SLC17A5
12 dengue hemorrhagic fever 30.0 ALB F2
13 portal hypertension 29.8 ALB F2 GPT
14 non-a-e hepatitis 29.8 ALB F2
15 cryptogenic cirrhosis 29.8 F2 F5
16 hepatorenal syndrome 29.7 ALB F2
17 liver disease 29.7 ALB F2 GPT HGF SLC17A5
18 compartment syndrome 29.7 ALB F2 SLC17A5
19 nonalcoholic steatohepatitis 29.7 F2 GPT SLC17A5
20 biliary atresia 29.5 ALB GPT HGF
21 obstructive nephropathy 29.5 ALB HGF
22 protein s deficiency 29.5 F2 F5
23 hepatic tuberculosis 29.5 ALB F2 GPT
24 cholecystitis 29.5 ALB F2 GPT
25 paracetamol poisoning 29.5 F2 F5 GC
26 cholangitis 29.5 ALB F2 GPT
27 factor x deficiency 29.4 F2 F5
28 disseminated intravascular coagulation 29.3 F2 F5
29 hepatic encephalopathy 29.3 ALB F2 GC GPT SLC17A5 TSPO
30 liver cirrhosis 29.2 ALB F2 GPT HGF SLC17A5
31 bilirubin metabolic disorder 29.1 ALB F2 GPT SLC17A5
32 alcoholic hepatitis 29.1 ALB F2 GPT SLC17A5
33 pulmonary embolism 29.1 ALB F2 F5
34 liver failure, infantile, transient 11.6
35 epiphyseal dysplasia, multiple, with early-onset diabetes mellitus 11.5
36 infantile liver failure syndrome 2 11.5
37 ruijs-aalfs syndrome 11.3
38 mpv17-related hepatocerebral mitochondrial dna depletion syndrome 11.3
39 mitochondrial dna depletion syndrome 4a 11.0
40 encephalopathy 10.5
41 brain edema 10.4
42 lymphoma 10.4
43 hepatoportal sclerosis 10.3 F2 GPT
44 hepatitis d 10.3 F2 GPT
45 paraquat poisoning 10.3 GPT SLC17A5
46 pyridoxine deficiency 10.3 GPT SLC17A5
47 hemophagocytic lymphohistiocytosis 10.3
48 herpes simplex 10.3
49 fatty liver disease, nonalcoholic 1 10.2 GPT SLC17A5
50 autoimmune hepatitis 10.2

Graphical network of the top 20 diseases related to Acute Liver Failure:

Diseases related to Acute Liver Failure

Symptoms & Phenotypes for Acute Liver Failure

Drugs & Therapeutics for Acute Liver Failure

Drugs for Acute Liver Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 218)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Acetylcysteine Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 616-91-1 12035
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
Pantoprazole Approved Phase 4 102625-70-7 4679
Haloperidol Approved Phase 4 52-86-8 3559
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
11 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
12 Gastrointestinal Agents Phase 4,Not Applicable
13 Protective Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
14 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
15 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
16 Antiviral Agents Phase 4,Phase 3,Phase 1,Not Applicable
17 Anti-Ulcer Agents Phase 4,Not Applicable
18 Antacids Phase 4,Not Applicable
19 Neurotransmitter Agents Phase 4,Phase 2,Not Applicable
20 Expectorants Phase 4,Phase 3,Phase 1,Not Applicable
21 N-monoacetylcystine Phase 4,Phase 3,Phase 1,Not Applicable
22 Antidotes Phase 4,Phase 3,Phase 1,Not Applicable
23 Antioxidants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
24 Free Radical Scavengers Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
25 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Not Applicable
26 Respiratory System Agents Phase 4,Phase 3,Phase 1,Not Applicable
27 Anti-Bacterial Agents Phase 4,Phase 2,Phase 1,Not Applicable
28 Antiemetics Phase 4
29 Methylprednisolone Acetate Phase 4
30 Antineoplastic Agents, Hormonal Phase 4
31 Hormone Antagonists Phase 4
32 Neuroprotective Agents Phase 4
33 glucocorticoids Phase 4
34 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
35 Prednisolone acetate Phase 4
36 Anti-Inflammatory Agents Phase 4,Not Applicable
37 Hormones Phase 4
38 Autonomic Agents Phase 4,Not Applicable
39 Anti-HIV Agents Phase 4
40 Nucleic Acid Synthesis Inhibitors Phase 4
41 Reverse Transcriptase Inhibitors Phase 4
42 Anti-Retroviral Agents Phase 4
43 Proton Pump Inhibitors Phase 4
44 Haloperidol decanoate Phase 4
45 Antipsychotic Agents Phase 4
46 Dopamine Antagonists Phase 4
47 Tranquilizing Agents Phase 4
48 Psychotropic Drugs Phase 4
49 Dopamine Agents Phase 4
50 Central Nervous System Depressants Phase 4

Interventional clinical trials:

(show top 50) (show all 92)
# Name Status NCT ID Phase Drugs
1 Assessment of Coagulation Abnormalities in Acute on Chronic Liver Failure Patients Using Thromboelastography Unknown status NCT02757170 Phase 4
2 Steroids in Fulminant Hepatitis A in the Pediatric Age Group Completed NCT02375867 Phase 4 prednisolone;methylprednisolone
3 A Randomized Controlled Trial of Lamivudine in Acute Hepatitis B Completed NCT00380614 Phase 4 Lamivudine
4 Liver Function After Intravenous Methylprednisolone Administration Completed NCT03667157 Phase 4 every week IVMP therapy;very high doses IVMP therapy
5 Stress Ulcer Prophylaxis in the Intensive Care Unit Completed NCT02467621 Phase 4 Pantoprazole
6 Agents Intervening Against Delirium in Intensive Care Unit Recruiting NCT03392376 Phase 4 Haloperidol Injection
7 Study of N-Acetylcysteine in Acute Liver Failure (ALF) Terminated NCT00896025 Phase 4 N-acetylcysteine
8 Minocycline Administration During Human Liver Transplantation Withdrawn NCT02712775 Phase 4 Minocycline (yes/no);Placebo
9 N-acetylcysteine in Non-Acetaminophen Pediatric Acute Liver Failure Completed NCT00248625 Phase 3 N-acetylcysteine;Placebo
10 Randomized Study of Acetylcysteine in Patients With Acute Liver Failure Not Caused by Acetaminophen Completed NCT00004467 Phase 3 N-acetylcysteine (NAC);Placebo
11 The MARS® Albumin Dialysis System in Patients With Fulminant and Subfulminant Hepatic Failure Completed NCT00224705 Phase 3
12 MK-0524B Lipid Study (MK-0524B-063) Completed NCT00479882 Phase 3 Comparator: simvastatin;MK-0524A;Placebo;MK-0524B
13 Lipid Efficacy and Safety in Participants With Mixed Hyperlipidemia (MK-0524B-024) Completed NCT00289900 Phase 3 MK-0524A;Atorvastatin;Simvastatin
14 13C-Methacetin Breath Test for the Prediction of Outcome in in ALI or ALF Recruiting NCT02786836 Phase 2, Phase 3 13C-Methacetin
15 To Assess Safety/Efficacy of ELAD in Subjects w/ Severe Acute Alcoholic Hepatitis (sAAH) and Lille Score Failure Terminated NCT01829347 Phase 3
16 A Study to Evaluate Efficacy and Safety of Extended-Release Niacin + Laropiprant + Simvastatin in Participants With Primary Hypercholesterolemia or Mixed Dyslipidemia (MK-0524B-118) Terminated NCT01294683 Phase 3 Simvastatin;Extended Release (ER) niacin/laropiprant/simvastatin (N/LRPT/SIM);Extended Release (ER) niacin/laropiprant (N/LRPT);Placebo
17 Registry Protocol for Tracking Trial Subjects After VTI-206 Study Completion Withdrawn NCT01452295 Phase 2, Phase 3 ELAD (Extracorporeal Liver Assist System)
18 Cardiox Liver Function Test Pivotal Trial Withdrawn NCT02552901 Phase 3 0.1 mg/kg ICG Dose;0.5 mg/kg ICG dose
19 Therapeutic Efficacy of L-Ornithine L-Aspartate Infusion in Patients With Acute Liver Failure Unknown status NCT00470314 Phase 2 L-Ornithine L-Aspartate
20 Efficacy & Safety of ALF-5755 in Patients With Nonacetaminophen Severe Acute Hepatitis & Early Stage Acute Liver Failure Unknown status NCT01318525 Phase 2 ALF-5755;Saline solution (0.9% NaCl)
21 Phase I/II Study of Recombinant Human Hepatocyte Growth Factor in Fulminant Hepatic Failure Unknown status NCT00225901 Phase 1, Phase 2 Recombinant human hepatocyte growth factor
22 Molecular Adsorbent Recirculating System (MARS®) in Hypoxic Hepatitis Unknown status NCT01690845 Phase 2
23 Mesenchymal Stem Cells After Renal or Liver Transplantation Unknown status NCT01429038 Phase 1, Phase 2
24 Safety Study of Ornithine Phenylacetate to Treat Patients With Acute Liver Failure/Severe Acute Liver Injury Completed NCT01548690 Phase 2 Ornithine Phenylacetate
25 Emergency Use of OCR-002 in Acute Liver Failure Completed NCT01634230 Phase 2 OCR-002
26 Phase 2 Evaluation of the ELAD System in the Management of Acute Liver Failure Completed NCT00030225 Phase 2
27 Safety & Efficacy of the Extracorporeal Liver Assist Device (ELAD) System in Patients With Hepatic Insufficiency Completed NCT00771446 Phase 1, Phase 2
28 Study to Evaluate Safety and Efficacy of LifeLiver in Acute or Acute-on-Chronic Liver Failure Patients Recruiting NCT03882346 Phase 2
29 Safety and Efficacy of the ELAD System (ELAD) to Treat Acute Liver Failure (ALF) Terminated NCT01875874 Phase 2
30 Pharmacokinetic and Pharmacodynamic Study of IDN-6556 in ACLF Terminated NCT01937130 Phase 2 IDN-6556
31 Safety and Efficacy of the Extracorporeal Liver Assist Device (ELAD®) In Patients With Fulminant Hepatic Failure (FHF) Withdrawn NCT00832728 Phase 2
32 Hepatocyte Transplantation in Liver Failure Withdrawn NCT00805610 Phase 1, Phase 2
33 Macrophage Markers, Soluble CD163 (sCD163) and Soluble CD206 (sCD206) in Paracetamol Overdose Completed NCT03679442 Phase 1 N-acetylcysteine
34 A Study to Evaluate the Pharmacokinetics of Acetaminophen and Its Toxic Metabolites With 2 Formulations (Panadol and SafeTynadol) in Healthy Volunteers Completed NCT03451487 Phase 1 Panadol®;SafeTynadol®
35 Safety Study of Stemchymal® in Acute Liver Failure Not yet recruiting NCT03629015 Phase 1
36 A Phase 1 Study of LJPC-501 in Patients With Hepatorenal Syndrome Terminated NCT01906307 Phase 1 LJPC-501
37 Hepatocyte Transplantation for Acute Decompensated Liver Failure Withdrawn NCT01345565 Phase 1 human hepatocytes
38 Granulocyte Colony Stimulating Factor (G-CSF) in Acute Liver Failure and Alcoholic Hepatitis Unknown status NCT01341951 Not Applicable Granulocyte colony stimulating factor
39 Growth Factors and Hepatic Progenitor Cells in Acute Liver Failure Unknown status NCT01312220
40 Breath Test for Patients With Acute Liver Disease for Early Detection of the Need for Transplant or Recovery Unknown status NCT01435421
41 Removal of Protein Bound Uremic Toxins by Modified Plasma Separation and Adsorption Combined With Hemodialysis Unknown status NCT00375635 Not Applicable
42 Clinical and Basic Research of ETV Plus GM-CSF in Chronic Hepatitis B Patients Unknown status NCT03164889 Not Applicable Granulocyte Macrophage-colony Stimulating Factor;Entecavir
43 Evolution and Clinical Outcomes in Patients Undergoing Liver Transplantation Unknown status NCT02917382
44 Mechanisms of N-acetylcysteine Mediated Vascular Adverse Effects Unknown status NCT01209455 Not Applicable Chlorphenamine and Ranitidine;Paracetamol;Paracetamol
45 Oxidative Stress and Microcirculation in Patient With Hepatic Failure Undergoing Liver Support Treatment Unknown status NCT00772252
46 Hepatitis B Antigen Kidney Graft Into Protective Level Hepatitis B Antibody Recipients Unknown status NCT02044588
47 Evaluation of Mechanisms Responsible for Coma in Patients Affected by Fulminant, Acute and Chronic Hepatic Failure Unknown status NCT01582087
48 Clinical and Basic Study for Pediatric Liver Transplantation Unknown status NCT02503384
49 High Volume Plasma Exchange in Children With Acute Liver Failure and Acute on Chronic Liver Failure Completed NCT02719210 Not Applicable Hypertonic 3% saline;Mannitol
50 A Multi-Center Group to Study Acute Liver Failure in Children Completed NCT00986648

Search NIH Clinical Center for Acute Liver Failure

Cell-based therapeutics:

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Acute Liver Failure cell therapies at LifeMap Discovery.

Genetic Tests for Acute Liver Failure

Genetic tests related to Acute Liver Failure:

# Genetic test Affiliating Genes
1 Fulminant Hepatic Failure 30

Anatomical Context for Acute Liver Failure

MalaCards organs/tissues related to Acute Liver Failure:

Liver, Brain, Testes, Bone, Kidney, Lung, T Cells
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Acute Liver Failure:
# Tissue Anatomical CompartmentCell Relevance
1 Liver Liver Lobule Hepatocytes Affected by disease, potential therapeutic candidate

Publications for Acute Liver Failure

Articles related to Acute Liver Failure:

(show top 50) (show all 3779)
# Title Authors Year
Acute liver failure in two dogs following ingestion of cheese tree (Glochidion ferdinandi) roots. ( 30507024 )
Reply to: "Acute liver failure due to immune-mediated hepatitis successfully managed with plasma exchange: New settings call for new treatment strategies?" ( 30527952 )
Exosomes derived from human umbilical cord mesenchymal stem cells alleviate acute liver failure by reducing the activity of the NLRP3 inflammasome in macrophages. ( 30528233 )
Mesenchymal stem cells increase heme oxygenase 1-activated autophagy in treatment of acute liver failure. ( 30528392 )
Novel neuroblastoma amplified sequence (NBAS) mutations in a Japanese boy with fever-triggered recurrent acute liver failure. ( 30622725 )
Acute liver failure: Running fast between the traps. ( 30635100 )
Hepatoprotective effects and structure-activity relationship of five flavonoids against lipopolysaccharide/d-galactosamine induced acute liver failure in mice. ( 30641432 )
Behavioral, Neurochemical and Brain Oscillation Abnormalities in an Experimental Model of Acute Liver Failure. ( 30654003 )
Dysregulated activation of fetal liver programme in acute liver failure. ( 30670575 )
The incidence, etiologies, outcomes, and predictors of mortality of acute liver failure in Thailand: a population-base study. ( 30691414 )
Update on the management of acute liver failure. ( 30694840 )
Therapeutic Potential of Plasma Proteins Derived from Umbilical Cord Blood for Acute Liver Failure. ( 30698974 )
Mutation in ITCH Gene Can Cause Syndromic Multisystem Autoimmune Disease With Acute Liver Failure. ( 30705142 )
The antagonistic effect of tamoxifen against d-galactosamine/lipopolysaccharide-induced acute liver failure is associated with reactivation of hepatic nuclear factor-κB. ( 30721100 )
Acetaminophen is Undetectable in Plasma From More Than Half of Patients Believed to Have Acute Liver Failure Due to Overdose. ( 30731196 )
Intracranial Pressure Evaluation in Acute Liver Failure. ( 30734243 )
Acute liver failure increases kynurenic acid production in rat brain via changes in tryptophan metabolism in the periphery. ( 30738081 )
Correction: Cytokine profiles in acute liver injury-Results from the US Drug-Induced Liver Injury Network (DILIN) and the Acute Liver Failure Study Group. ( 30742679 )
Author's Response to Letter to the Editor: Noninvasive Intracranial Pressure Assessment in Acute Liver Failure. ( 30756317 )
Neurological Recovery After Recovery From Acute Liver Failure: Is it Complete? ( 30765942 )
Drug-induced idiosyncratic acute liver failure: A challenging and distressing scenario. ( 30767751 )
Corticosteroid Therapy for Indeterminate Pediatric Acute Liver Failure and Aplastic Anemia with Acute Hepatitis. ( 30770193 )
Obeticholic acid differentially regulates hepatic injury and inflammation at different stages of D-galactosamine/lipopolysaccharide-evoked acute liver failure. ( 30772394 )
Quantitative real-time PCR for differential diagnostics of parvovirus B19 infection in acute liver failure patients. ( 30773069 )
Acute liver failure caused by occupational exposure to HCFC-123: Two case reports. ( 30817569 )
Down-regulation of miR-122 after transplantation of mesenchymal stem cells in acute liver failure in mice model. ( 30824230 )
Host Genetic Variant in CXCL16 May Be Associated With Hepatitis B Virus-Related Acute Liver Failure. ( 30827414 )
Extracorporeal Liver Support in Patients with Acute Liver Failure. ( 30833847 )
Recurrent acute liver failure associated with novel SCYL1 mutation: A case report. ( 30842961 )
Live donor liver transplantation for acute liver failure - Donor safety and recipient outcome. ( 30861306 )
Peripheral infusion of human umbilical cord mesenchymal stem cells rescues acute liver failure lethality in monkeys. ( 30867056 )
rhIL-1Ra reduces hepatocellular apoptosis in mice with acute liver failure mainly by inhibiting the activities of Kupffer cells. ( 30902658 )
An Unusual Case of Acute Liver Failure Caused by Adjuvant Oral Tegafur-Uracil with Folinate Therapy for Colon Cancer Patient: a Case Report. ( 30903577 )
Downregulation of microRNA-214 improves therapeutic potential of allogeneic bone marrow-derived mesenchymal stem cell by targeting PIM-1 in rats with acute liver failure. ( 30938885 )
Elevated circulating TGFβ1 during acute liver failure activates TGFβR2 on cortical neurons and exacerbates neuroinflammation and hepatic encephalopathy in mice. ( 30940161 )
Deteriorated Outcome of Recent Patients with Acute Liver Failure and Late-Onset Hepatic Failure Caused by Infection with Hepatitis A Virus: A Subanalysis of Patients Seen Between 1998 and 2015 and Enrolled in Nationwide Surveys in Japan. ( 30957325 )
Protective action of glutamine in rats with severe acute liver failure. ( 30967905 )
Acute liver failure associated with Fructus Psoraleae: a case report and literature review. ( 30975110 )
Leukocyte cell derived chemotaxin-2 (Lect2) as a predictor of survival in adult acute liver failure. ( 30976720 )
Protective properties of the cultured stem cell proteome studied in an animal model of acetaminophen-induced acute liver failure. ( 30977085 )
HMGB1 is a Central Driver of Dynamic Pro-inflammatory Networks in Pediatric Acute Liver Failure induced by Acetaminophen. ( 30979951 )
Case Report: Levetiracetam causing acute liver failure complicating post-operative management in a neurosurgical patient. ( 30984385 )
Novel Mutation in GALT Gene in Galactosemia Patient with Group B Streptococcus Meningitis and Acute Liver Failure. ( 30987402 )
Acute liver injury, acute liver failure and acute on chronic liver failure: A clinical spectrum of poisoning due to Gyromitra esculenta. ( 31014949 )
Outcomes of renal dysfunction in patients with acute liver failure. ( 31019707 )
Slimming to the Death: Herbalife®-Associated Fatal Acute Liver Failure-Heavy Metals, Toxic Compounds, Bacterial Contaminants and Psychotropic Agents in Products Sold in India. ( 31024209 )
Significantly enhanced recovery of acute liver failure by liver targeted delivery of stem cells via heparin functionalization. ( 31026612 )
Endoplasmic Reticulum Stress-induced Upregulation of STARD1 Promotes Acetaminophen-induced Acute Liver Failure. ( 31029706 )
Atractylodin ameliorates lipopolysaccharide and d-galactosamine-induced acute liver failure via the suppression of inflammation and oxidative stress. ( 31030090 )
HDAC2 inhibitor CAY10683 reduces intestinal epithelial cell apoptosis by inhibiting mitochondrial apoptosis pathway in acute liver failure. ( 31032867 )

Variations for Acute Liver Failure

ClinVar genetic disease variations for Acute Liver Failure:

# Gene Variation Type Significance SNP ID Assembly Location
1 POLG2 NM_007215.3(POLG2): c.544C> T (p.Arg182Trp) single nucleotide variant Likely pathogenic rs886037843 GRCh37 Chromosome 17, 62492543: 62492543
2 POLG2 NM_007215.3(POLG2): c.544C> T (p.Arg182Trp) single nucleotide variant Likely pathogenic rs886037843 GRCh38 Chromosome 17, 64496425: 64496425
3 MT-CO3 NC_012920.1: m.9355A> T single nucleotide variant Uncertain significance rs1556423663 GRCh37 Chromosome MT, 9355: 9355
4 MT-CO3 NC_012920.1: m.9355A> T single nucleotide variant Uncertain significance rs1556423663 GRCh38 Chromosome MT, 9355: 9355

Expression for Acute Liver Failure

Search GEO for disease gene expression data for Acute Liver Failure.

Pathways for Acute Liver Failure

Pathways related to Acute Liver Failure according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.27 ALB F2

GO Terms for Acute Liver Failure

Cellular components related to Acute Liver Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.43 ALB F2 F5
2 extracellular space GO:0005615 9.43 ALB F2 F5 GC GPT HGF
3 blood microparticle GO:0072562 9.33 ALB F2 GC
4 platelet alpha granule lumen GO:0031093 8.8 ALB F5 HGF

Biological processes related to Acute Liver Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.43 ALB F2 F5
2 hemostasis GO:0007599 9.32 F2 F5
3 positive regulation of reactive oxygen species metabolic process GO:2000379 9.16 F2 TSPO
4 anion transport GO:0006820 8.96 SLC17A5 TSPO
5 platelet degranulation GO:0002576 8.8 ALB F5 HGF

Molecular functions related to Acute Liver Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pyridoxal phosphate binding GO:0030170 8.62 ALB GPT

Sources for Acute Liver Failure

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
33 HPO
34 ICD10
35 ICD10 via Orphanet
39 LifeMap
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
56 Novoseek
59 OMIM via Orphanet
63 PubMed
71 SNOMED-CT via Orphanet
73 Tocris
75 UMLS via Orphanet
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