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MCID: ACT134
MIFTS: 52

Acute Liver Failure

Categories: Liver diseases, Rare diseases, Genetic diseases, Metabolic diseases, Gastrointestinal diseases, Endocrine diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
Sources

Aliases & Classifications for Acute Liver Failure

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MalaCards integrated aliases for Acute Liver Failure:

Name: Acute Liver Failure 38 59 55
Fulminant Hepatic Failure 59 37 29
Acute Hepatic Failure 59 6
Hepatic Failure Fulminant 55
Liver Failure, Acute 73
Liver Failure Acute 55

Characteristics:

Orphanet epidemiological data:

59
acute liver failure
Prevalence: 1-5/10000 (Europe);

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases Metabolic diseases
Anatomical: Liver diseases Gastrointestinal diseases Endocrine diseases
See all MalaCards categories (disease lists)
ICD10: 34
Orphanet: 59  
Rare hepatic diseases


External Ids:

Orphanet 59 ORPHA90062
MESH via Orphanet 45 D017114
UMLS via Orphanet 74 C0162557
ICD10 via Orphanet 34 K72.0
KEGG 37 H01712
UMLS 73 C0162557
Sources

Summaries for Acute Liver Failure

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MalaCards based summary : Acute Liver Failure, also known as fulminant hepatic failure, is related to hepatitis and wilson disease. An important gene associated with Acute Liver Failure is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways is FOXA2 and FOXA3 transcription factor networks. The drugs Acetylcysteine and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include Liver, liver and brain.

Wikipedia : 76 Acute liver failure is the appearance of severe complications rapidly after the first signs of liver... more...

Sources

Related Diseases for Acute Liver Failure

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Diseases in the Liver Disease family:

Liver Failure, Infantile, Transient Infantile Liver Failure Syndrome 1
Infantile Liver Failure Syndrome 2 Acute Liver Failure

Diseases related to Acute Liver Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 225)
# Related Disease Score Top Affiliating Genes
1 hepatitis 32.2 F2 GPT SLC17A5
2 wilson disease 30.1 ALB F2 GPT
3 scrub typhus 30.1 GPT SLC17A5
4 hepatitis a 30.0 ALB F2 GPT
5 non-a-e hepatitis 29.9 ALB F2
6 hepatitis e 29.9 ALB F2 GPT
7 hepatorenal syndrome 29.7 ALB F2
8 dengue hemorrhagic fever 29.6 ALB F2
9 hemorrhagic fever 29.6 ALB F2 GPT
10 intracranial hypertension 29.5 F2 F5
11 hepatitis b 29.4 ALB F2 GPT SLC17A5
12 protein s deficiency 29.3 F2 F5
13 hepatic tuberculosis 29.3 ALB F2 GPT
14 portal hypertension 29.2 ALB F2 GPT
15 factor x deficiency 29.1 F2 F5
16 viral hepatitis 29.0 ALB F2 GPT SLC17A5
17 biliary atresia 28.9 ALB GPT HGF
18 hepatic coma 28.6 ALB F2 GPT TSPO
19 alcoholic hepatitis 28.5 ALB F2 GPT SLC17A5
20 liver disease 28.4 ALB F2 GPT HGF SLC17A5
21 hepatic encephalopathy 27.4 ALB F2 GC GPT SLC17A5 TSPO
22 infantile liver failure syndrome 1 11.6
23 liver failure, infantile, transient 11.4
24 epiphyseal dysplasia, multiple, with early-onset diabetes mellitus 11.3
25 ruijs-aalfs syndrome 11.1
26 infantile liver failure syndrome 2 11.0
27 mitochondrial dna depletion syndrome 4a 10.9
28 hepatoportal sclerosis 10.7 F2 GPT
29 hepatitis d 10.6 F2 GPT
30 paraquat poisoning 10.6 GPT SLC17A5
31 pyridoxine deficiency 10.6 GPT SLC17A5
32 separation anxiety disorder 10.4 NBAS TSPO
33 antipyrine metabolism 10.4 ALB F2
34 fournier gangrene 10.4 ALB F2
35 abdominal tuberculosis 10.4 ALB F2
36 splenic disease 10.3 ALB F2
37 esophageal varix 10.3 ALB F2
38 ascending cholangitis 10.3 ALB F2
39 hypersplenism 10.3 ALB F2
40 brain edema 10.3
41 hepatic vascular disease 10.3 ALB F2
42 legionnaires' disease 10.2 ALB SLC17A5
43 nonalcoholic steatohepatitis 10.2 F2 GPT SLC17A5
44 protein-energy malnutrition 10.2 ALB GPT
45 intermittent claudication 10.2 ALB F2
46 encephalopathy 10.1
47 burns 10.1 ALB HGF
48 spinal cord infarction 10.1 F2 F5
49 nutritional deficiency disease 10.1 ALB F2
50 livedoid vasculopathy 10.1 F2 F5

Graphical network of the top 20 diseases related to Acute Liver Failure:



Diseases related to Acute Liver Failure
Sources

Symptoms & Phenotypes for Acute Liver Failure

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Sources

Drugs & Therapeutics for Acute Liver Failure

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Drugs for Acute Liver Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 203)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcysteine Approved, Investigational Phase 4,Phase 3,Not Applicable 616-91-1 12035
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
5
Pantoprazole Approved Phase 4 102625-70-7 4679
6
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
7
Haloperidol Approved Phase 4 52-86-8 3559
8 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
9 Gastrointestinal Agents Phase 4,Not Applicable
10 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
11 Protective Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
12 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
13 Antiviral Agents Phase 4,Phase 3,Not Applicable
14 Antacids Phase 4,Not Applicable
15 Anti-Ulcer Agents Phase 4,Not Applicable
16 Neurotransmitter Agents Phase 4,Phase 2,Not Applicable
17 Antidotes Phase 4,Phase 3,Not Applicable
18 Antioxidants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
19 Expectorants Phase 4,Phase 3,Not Applicable
20 N-monoacetylcystine Phase 4,Phase 3,Not Applicable
21 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Not Applicable
22 Respiratory System Agents Phase 4,Phase 3,Not Applicable
23 Anti-Bacterial Agents Phase 4,Phase 1,Phase 2,Not Applicable
24 Antiemetics Phase 4
25 Anti-Inflammatory Agents Phase 4,Not Applicable
26 Antineoplastic Agents, Hormonal Phase 4
27 Autonomic Agents Phase 4,Not Applicable
28 glucocorticoids Phase 4
29 Hormone Antagonists Phase 4
30 Hormones Phase 4
31 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
32 Methylprednisolone acetate Phase 4
33 Methylprednisolone Hemisuccinate Phase 4
34 Neuroprotective Agents Phase 4
35 Prednisolone acetate Phase 4
36 Prednisolone hemisuccinate Phase 4
37 Prednisolone phosphate Phase 4
38 Anti-HIV Agents Phase 4
39 Anti-Retroviral Agents Phase 4
40 Nucleic Acid Synthesis Inhibitors Phase 4
41 Reverse Transcriptase Inhibitors Phase 4
42 Proton Pump Inhibitors Phase 4
43 Antipsychotic Agents Phase 4
44 Central Nervous System Depressants Phase 4
45 decanoic acid Phase 4
46 Dopamine Agents Phase 4
47 Dopamine Antagonists Phase 4
48 Haloperidol decanoate Phase 4
49 Psychotropic Drugs Phase 4
50 Tranquilizing Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 82)
# Name Status NCT ID Phase Drugs
1 Assessment of Coagulation Abnormalities in Acute on Chronic Liver Failure Patients Using Thromboelastography Unknown status NCT02757170 Phase 4
2 Steroids in Fulminant Hepatic Failure in the Pediatric Age Group Completed NCT02375867 Phase 4 prednisolone;methylprednisolone
3 A Randomized Controlled Trial of Lamivudine in Acute Hepatitis B Completed NCT00380614 Phase 4 Lamivudine
4 Stress Ulcer Prophylaxis in the Intensive Care Unit Completed NCT02467621 Phase 4 Pantoprazole
5 Agents Intervening Against Delirium in Intensive Care Unit Recruiting NCT03392376 Phase 4 Haloperidol Injection
6 Study of N-Acetylcysteine in Acute Liver Failure (ALF) Terminated NCT00896025 Phase 4 N-acetylcysteine
7 Minocycline Administration During Human Liver Transplantation Withdrawn NCT02712775 Phase 4 Minocycline (yes/no);Placebo
8 N-acetylcysteine in Non-Acetaminophen Pediatric Acute Liver Failure Completed NCT00248625 Phase 3 N-acetylcysteine;Placebo
9 Randomized Study of Acetylcysteine in Patients With Acute Liver Failure Not Caused by Acetaminophen Completed NCT00004467 Phase 3 N-acetylcysteine (NAC);Placebo
10 The MARS® Albumin Dialysis System in Patients With Fulminant and Subfulminant Hepatic Failure Completed NCT00224705 Phase 3
11 MK-0524B Lipid Study (MK-0524B-063) Completed NCT00479882 Phase 3 Comparator: simvastatin;MK-0524A;Placebo;MK-0524B
12 Lipid Efficacy and Safety in Participants With Mixed Hyperlipidemia (MK-0524B-024) Completed NCT00289900 Phase 3 MK-0524A;Atorvastatin;Simvastatin
13 13C-Methacetin Breath Test for the Prediction of Outcome in in ALI or ALF Recruiting NCT02786836 Phase 2, Phase 3 13C-Methacetin
14 Study to Assess Safety and Efficacy of ELAD in Subjects With Severe Acute Alcoholic Hepatitis (sAAH) and Lille Score Failure Terminated NCT01829347 Phase 3
15 A Study to Evaluate Efficacy and Safety of Extended-Release Niacin + Laropiprant + Simvastatin in Participants With Primary Hypercholesterolemia or Mixed Dyslipidemia (MK-0524B-118) Terminated NCT01294683 Phase 3 Simvastatin;Extended Release (ER) niacin/laropiprant/simvastatin (N/LRPT/SIM);Extended Release (ER) niacin/laropiprant (N/LRPT);Placebo
16 Registry Protocol for Tracking Trial Subjects After VTI-206 Study Completion Withdrawn NCT01452295 Phase 2, Phase 3 ELAD (Extracorporeal Liver Assist System)
17 Cardiox Liver Function Test Pivotal Trial Withdrawn NCT02552901 Phase 3 0.1 mg/kg ICG Dose;0.5 mg/kg ICG dose
18 Therapeutic Efficacy of L-Ornithine L-Aspartate Infusion in Patients With Acute Liver Failure Unknown status NCT00470314 Phase 2 L-Ornithine L-Aspartate
19 Efficacy & Safety of ALF-5755 in Patients With Nonacetaminophen Severe Acute Hepatitis & Early Stage Acute Liver Failure Unknown status NCT01318525 Phase 2 ALF-5755;Saline solution (0.9% NaCl)
20 Phase I/II Study of Recombinant Human Hepatocyte Growth Factor in Fulminant Hepatic Failure Unknown status NCT00225901 Phase 1, Phase 2 Recombinant human hepatocyte growth factor
21 Mesenchymal Stem Cells After Renal or Liver Transplantation Unknown status NCT01429038 Phase 1, Phase 2
22 Safety Study of Ornithine Phenylacetate to Treat Patients With Acute Liver Failure Completed NCT01548690 Phase 2 Ornithine phenylacetate
23 Emergency Use of OCR-002 in Acute Liver Failure Completed NCT01634230 Phase 2 OCR-002
24 Phase 2 Evaluation of the ELAD System in the Management of Acute Liver Failure Completed NCT00030225 Phase 2
25 Safety & Efficacy of the Extracorporeal Liver Assist Device (ELAD) System in Patients With Hepatic Insufficiency Completed NCT00771446 Phase 1, Phase 2
26 Molecular Adsorbent Recirculating System (MARS®) in Hypoxic Hepatitis Recruiting NCT01690845 Phase 2
27 Safety and Efficacy of ELAD to Treat Acute Liver Failure (ALF) Terminated NCT01875874 Phase 2
28 Pharmacokinetic and Pharmacodynamic Study of IDN-6556 in ACLF Terminated NCT01937130 Phase 2 IDN-6556
29 Safety and Efficacy of the Extracorporeal Liver Assist Device (ELAD®) In Patients With Fulminant Hepatic Failure (FHF) Withdrawn NCT00832728 Phase 2
30 Hepatocyte Transplantation in Liver Failure Withdrawn NCT00805610 Phase 1, Phase 2
31 A Study to Evaluate the Pharmacokinetics of Acetaminophen and Its Toxic Metabolites With 2 Formulations (Panadol and SafeTynadol) in Healthy Volunteers Completed NCT03451487 Phase 1 Panadol®;SafeTynadol®
32 Hepatocyte Transplantation for Acute Decompensated Liver Failure Suspended NCT01345565 Phase 1 human hepatocytes
33 A Phase 1 Study of LJPC-501 in Patients With Hepatorenal Syndrome Terminated NCT01906307 Phase 1 LJPC-501
34 Granulocyte Colony Stimulating Factor (G-CSF) in Acute Liver Failure and Alcoholic Hepatitis Unknown status NCT01341951 Not Applicable Granulocyte colony stimulating factor
35 Growth Factors and Hepatic Progenitor Cells in Acute Liver Failure Unknown status NCT01312220
36 Breath Test for Patients With Acute Liver Disease for Early Detection of the Need for Transplant or Recovery Unknown status NCT01435421
37 Removal of Protein Bound Uremic Toxins by Modified Plasma Separation and Adsorption Combined With Hemodialysis Unknown status NCT00375635 Not Applicable
38 Mechanisms of N-acetylcysteine Mediated Vascular Adverse Effects Unknown status NCT01209455 Not Applicable Chlorphenamine and Ranitidine;Paracetamol;Paracetamol
39 Oxidative Stress and Microcirculation in Patient With Hepatic Failure Undergoing Liver Support Treatment Unknown status NCT00772252
40 Hepatitis B Antigen Kidney Graft Into Protective Level Hepatitis B Antibody Recipients Unknown status NCT02044588
41 Evaluation of Mechanisms Responsible for Coma in Patients Affected by Fulminant, Acute and Chronic Hepatic Failure Unknown status NCT01582087
42 A Multi-Center Group to Study Acute Liver Failure in Children Completed NCT00986648
43 A Study of the Effect of Plasmaexchange in Patients With Acute Liver Failure Completed NCT00950508 Not Applicable
44 Risk of Acute Liver Failure Among Patients With Type 2 Diabetes Exposed to Oral Antidiabetic Treatments Completed NCT01086293
45 Cerebral Microdialysis in Patients With Fulminant Hepatic Failure Completed NCT00836420
46 The Effect of Prometheus (R) Liver Support Dialysis on Cerebral Metabolism in Acute Liver Failure Completed NCT00655304 Not Applicable
47 Indocyangreen Elimination in Cirrhosis and Acute Liver Failure Completed NCT00245310
48 Role of 13C Methacetin Breath Test in Predicting Prognosis Among Patients With Acute or Acute on Chronic Liver Failure (ACLF). Completed NCT01946360 Not Applicable
49 Unknown Cause of Acute Liver Failure Completed NCT02041637
50 Hypothermia to Prevent High Intracranial Pressure in Patients With Acute Liver Failure Completed NCT00670124 Not Applicable

Search NIH Clinical Center for Acute Liver Failure

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Acute Liver Failure cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Acute Liver Failure:
Hepatocyte transplantation for treatment of liver disorders
Hepatocyte transplantation for treatment of liver failure and inherited metabolic diseases
Liver cells for liver diseases
Embryonic/Adult Cultured Cells Related to Acute Liver Failure:
Hepatocytes PMIDs: 15239608 12777539 9580649 22789058 22167636
Liver cells PMIDs: 22532025 19295306 19796496 16454359 17060866
Sources

Genetic Tests for Acute Liver Failure

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Genetic tests related to Acute Liver Failure:

# Genetic test Affiliating Genes
1 Fulminant Hepatic Failure 29
Sources

Anatomical Context for Acute Liver Failure

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MalaCards organs/tissues related to Acute Liver Failure:

41
Liver, Brain, Testes, Endothelial, Kidney, Heart, Neutrophil
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Acute Liver Failure:
# Tissue Anatomical CompartmentCell Relevance
1 Liver Liver Lobule Hepatocytes Potential therapeutic candidate, affected by disease
Sources

Publications for Acute Liver Failure

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Articles related to Acute Liver Failure:

(show top 50) (show all 1034)
# Title Authors Year
1
Neutralization of CD95 ligand protects the liver against ischemia-reperfusion injury and prevents acute liver failure. ( 29374146 )
2018
2
Absolute quantitation of acetaminophen-modified human serum albumin in acute liver failure patients by LC-MS/MS. ( 29920820 )
2018
3
Challenges in the early diagnosis of patients with acute liver failure induced by amatoxin poisoning: Two case reports. ( 29979397 )
2018
4
Human liver organoids generated with single donor-derived multiple cells rescue mice from acute liver failure. ( 29321049 )
2018
5
Mesenchymal Stem Cell/Red Blood Cell-Inspired Nanoparticle Therapy in Mice with Carbon Tetrachloride-Induced Acute Liver Failure. ( 29943967 )
2018
6
Hepatitis A, cardiomyopathy, aplastic anemia, and acute liver failure: A devastating scenario. ( 29359844 )
2018
7
Acute Liver Failure due to Amanita phalloides Poisoning: Therapeutic Approach and Outcome. ( 29407307 )
2018
8
Acute Liver Failure of Indeterminate Etiology: A Comprehensive Systematic Approach by An Expert Committee to Establish Causality. ( 29946176 )
2018
9
Beyond KCH selection and options in acute liver failure. ( 29858744 )
2018
10
Liver transplantation for acute liver failure - a 30-year single center experience. ( 29848142 )
2018
11
Drug idiosyncrasy due to pirfenidone presenting as acute liver failure: Case report and mini-review of the literature. ( 29404521 )
2018
12
Case Report of Isoniazid-Related Acute Liver Failure Requiring Liver Transplantation. ( 29783726 )
2018
13
Acute Liver Failure in an Adolescent Male Induced by Human Herpesvirus 6 (HHV-6): A Case Report With Literature Review. ( 29390152 )
2018
14
Protective effect of Coptisine from Rhizoma Coptidis on LPS/D-GalN-induced acute liver failure in mice through up-regulating expression of miR-122. ( 29253766 )
2018
15
Acute liver failure due to liver parenchymal infiltration with acute myelogenous leukaemia in a patient with myelodysplastic syndrome. ( 29954762 )
2018
16
A good response to glucocorticoid for sub-acute liver failure: a case report. ( 29971256 )
2018
17
Liver maximum capacity (LiMAx) test as a helpful prognostic tool in acute liver failure with sepsis: a case report. ( 29925334 )
2018
18
Early Combination Therapy with Corticosteroid and Nucleoside Analogue Induces Rapid Resolution of Inflammation in Acute Liver Failure Due to Transient Hepatitis B Virus Infection. ( 29321429 )
2018
19
Noninvasive Intracranial Pressure Assessment in Acute Liver Failure. ( 29948998 )
2018
20
Hepatic Macrophages are the Cell Source of Hepatic Procalcitonin in Acute Liver Failure. ( 29913443 )
2018
21
Domino Liver Transplantation from a Child with Propionic Acidemia to a Child with Idiopathic Fulminant Hepatic Failure. ( 29725551 )
2018
22
A case of acute liver failure due to carfilzomib in multiple myeloma. ( 29969517 )
2018
23
Identification of key candidate genes and pathways in hepatitis B virus-associated acute liver failure by bioinformatical analysis. ( 29384847 )
2018
24
Acute Liver Failure Associated With Pomalidomide Therapy for Multiple Myeloma. ( 29907543 )
2018
25
Inappropriate use of the term of acute liver failure in a tertiary hospital. ( 29866512 )
2018
26
Macrophage-targeting and reactive oxygen species (ROS)-responsive nanopolyplexes mediate anti-inflammatory siRNA delivery against acute liver failure (ALF). ( 29855002 )
2018
27
Living Donor Liver Transplantation in Acute Liver Failure Patients with Grade IV Encephalopathy: Is Deep Hepatic Coma Still an Absolute Contraindication? A Successful Single-Center Experience. ( 29531210 )
2018
28
SCYL1 variants cause a syndrome with low I^-glutamyl-transferase cholestasis, acute liver failure, and neurodegeneration (CALFAN). ( 29419818 )
2018
29
Acute Liver Failure: Outcome and Value of Pediatric End-Stage Liver Disease Score in Pediatric Cases. ( 29851917 )
2018
30
Long-term outcome in patients with acute liver failure. ( 29927051 )
2018
31
Acute Liver Failure among Patients on Efavirenz-Based Antiretroviral Therapy. ( 29862098 )
2018
32
Dendritic cells with increased expression of suppressor of cytokine signaling 1(SOCS1) gene ameliorate lipopolysaccharide/d-galactosamine-induced acute liver failure. ( 29852455 )
2018
33
Comparison of Dynamic Changes Among Various Prognostic Scores in Viral Hepatitis-Related Acute Liver Failure. ( 29735790 )
2018
34
MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure. ( 28450389 )
2018
35
Mir-24 regulates hepatocyte apoptosis via BIM during acute liver failure. ( 29218090 )
2017
36
Drug-induced acute liver failure in children and adults: Results of a single-centre study of 128 patients. ( 29222960 )
2017
37
Intravenous amiodarone-induced acute liver failure in cardiac surgery intensive care unit. ( 29395301 )
2017
38
Prometheus therapy for the treatment of acute liver failure in patients after cardiac surgery. ( 29354174 )
2017
39
Decreased activity of plasma ADAMTS13 are related to enhanced cytokinemia and endotoxemia in patients with acute liver failure. ( 28894574 )
2017
40
Elevated procalcitonin is associated with bacterial infection during acute liver failure only when unrelated to acetaminophen intoxication. ( 28272093 )
2017
41
Novel NBAS mutations and fever-related recurrent acute liver failure in Chinese children: a retrospective study. ( 28629372 )
2017
42
A Case of Fulminant Hepatic Failure Secondary to Congestive Heart Failure Without Evidence of Acute Cardiac Decompensation. ( 28813731 )
2017
43
Protective role of hypoxia-inducible factor-1I+-dependent CD39 and CD73 in fulminant acute liver failure. ( 27899277 )
2017
44
High ferritin concentration in acute liver failure: the top of the iceberg? ( 28941305 )
2017
45
Liver transplantation is associated with good clinical outcome in patients with active tuberculosis and acute liver failure due to anti-tubercular treatment. ( 28054732 )
2017
46
Babesiosis Presenting as Acute Liver Failure. ( 29430231 )
2017
47
Is dengue emerging as important cause of acute liver failure in endemic regions? ( 28798927 )
2017
48
Acetaminophen-induced Acute Liver Failure Is More Common and More Severe in Women. ( 29199145 )
2017
49
Acute Liver Failure due to Trazodone and Diazepam. ( 28848778 )
2017
50
Delta model for end-stage liver disease and delta clinical prognostic indicator as predictors of mortality in patients with viral acute liver failure. ( 29291180 )
2017
Sources

Variations for Acute Liver Failure

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ClinVar genetic disease variations for Acute Liver Failure:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 POLG2 NM_007215.3(POLG2): c.544C> T (p.Arg182Trp) single nucleotide variant Likely pathogenic rs886037843 GRCh37 Chromosome 17, 62492543: 62492543
2 POLG2 NM_007215.3(POLG2): c.544C> T (p.Arg182Trp) single nucleotide variant Likely pathogenic rs886037843 GRCh38 Chromosome 17, 64496425: 64496425
3 MT-CO3 NC_012920.1: m.9355A> T single nucleotide variant Uncertain significance GRCh37 Chromosome MT, 9355: 9355
4 MT-CO3 NC_012920.1: m.9355A> T single nucleotide variant Uncertain significance GRCh38 Chromosome MT, 9355: 9355
Sources

Expression for Acute Liver Failure

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Search GEO for disease gene expression data for Acute Liver Failure.
Sources

Pathways for Acute Liver Failure

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Pathways related to Acute Liver Failure according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
FOXA2 and FOXA3 transcription factor networks 1
10.27 ALB F2
Sources

GO Terms for Acute Liver Failure

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Cellular components related to Acute Liver Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.43 ALB F2 F5
2 extracellular space GO:0005615 9.43 ALB F2 F5 GC GPT HGF
3 blood microparticle GO:0072562 9.33 ALB F2 GC
4 platelet alpha granule lumen GO:0031093 8.8 ALB F5 HGF

Biological processes related to Acute Liver Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.43 ALB F2 F5
2 anion transport GO:0006820 9.16 SLC17A5 TSPO
3 positive regulation of reactive oxygen species metabolic process GO:2000379 8.96 F2 TSPO
4 platelet degranulation GO:0002576 8.8 ALB F5 HGF
Sources

Sources for Acute Liver Failure

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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