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MCID: ACT134
MIFTS: 53

Acute Liver Failure

Categories: Blood diseases, Endocrine diseases, Gastrointestinal diseases, Genetic diseases, Liver diseases, Metabolic diseases, Nephrological diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Acute Liver Failure

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MalaCards integrated aliases for Acute Liver Failure:

Name: Acute Liver Failure 38 59 55
Fulminant Hepatic Failure 59 37 29
Acute Hepatic Failure 59 6
Hepatic Failure Fulminant 55
Liver Failure, Acute 73
Liver Failure Acute 55

Characteristics:

Orphanet epidemiological data:

59
acute liver failure
Prevalence: 1-5/10000 (Europe);

Classifications:

MalaCards categories:
Global: Rare diseases Metabolic diseases Genetic diseases
Anatomical: Liver diseases Gastrointestinal diseases Endocrine diseases Blood diseases Nephrological diseases
See all MalaCards categories (disease lists)
ICD10: 34
Orphanet: 59  
Rare hepatic diseases


External Ids:

Orphanet 59 ORPHA90062
MESH via Orphanet 45 D017114
UMLS via Orphanet 74 C0162557
ICD10 via Orphanet 34 K72.0
KEGG 37 H01712
UMLS 73 C0162557
Sources

Summaries for Acute Liver Failure

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MalaCards based summary : Acute Liver Failure, also known as fulminant hepatic failure, is related to infantile liver failure syndrome 1 and hepatitis. An important gene associated with Acute Liver Failure is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways is FOXA2 and FOXA3 transcription factor networks. The drugs Acetylcysteine and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include Liver, liver and brain.

Wikipedia : 76 Acute liver failure is the appearance of severe complications rapidly after the first signs of liver... more...

Sources

Related Diseases for Acute Liver Failure

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Diseases in the Liver Disease family:

Liver Failure, Infantile, Transient Infantile Liver Failure Syndrome 1
Infantile Liver Failure Syndrome 2 Acute Liver Failure

Diseases related to Acute Liver Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 323)
# Related Disease Score Top Affiliating Genes
1 infantile liver failure syndrome 1 32.5 ALB F2 GPT SLC17A5
2 hepatitis 32.3 F2 GPT SLC17A5
3 hepatitis e 30.5 ALB F2 GPT
4 wilson disease 30.3 ALB F2 GPT
5 hepatitis a 30.3 ALB F2 GPT
6 hepatitis b 30.3 ALB F2 GPT SLC17A5
7 scrub typhus 30.2 GPT SLC17A5
8 intracranial hypertension 30.0 F2 F5
9 dengue hemorrhagic fever 30.0 ALB F2
10 viral hepatitis 30.0 ALB F2 GPT SLC17A5
11 hemorrhagic fever 29.9 ALB F2 GPT
12 hepatic coma 29.9 ALB F2 GPT TSPO
13 liver disease 29.9 ALB F2 GPT HGF SLC17A5
14 cryptogenic cirrhosis 29.7 F2 F5
15 typhoid fever 29.7 ALB F2
16 non-a-e hepatitis 29.7 ALB F2
17 hepatorenal syndrome 29.6 ALB F2
18 biliary atresia 29.6 ALB GPT HGF
19 obstructive nephropathy 29.6 ALB HGF
20 paracetamol poisoning 29.5 F2 F5 GC
21 hepatic encephalopathy 29.5 ALB F2 GC GPT SLC17A5 TSPO
22 protein s deficiency 29.5 F2 F5
23 hepatic tuberculosis 29.5 ALB F2 GPT
24 cholecystitis 29.5 ALB F2 GPT
25 portal hypertension 29.5 ALB F2 GPT
26 compartment syndrome 29.4 ALB F2 SLC17A5
27 factor x deficiency 29.4 F2 F5
28 bilirubin metabolic disorder 29.2 ALB F2 GPT SLC17A5
29 alcoholic hepatitis 29.2 ALB F2 GPT SLC17A5
30 pulmonary embolism 29.2 ALB F2 F5
31 liver cirrhosis 29.0 ALB F2 GPT HGF SLC17A5
32 liver failure, infantile, transient 11.6
33 epiphyseal dysplasia, multiple, with early-onset diabetes mellitus 11.5
34 ruijs-aalfs syndrome 11.2
35 infantile liver failure syndrome 2 11.2
36 mitochondrial dna depletion syndrome 4a 11.0
37 brain edema 10.4
38 encephalopathy 10.4
39 viral infectious disease 10.3
40 hemophagocytic lymphohistiocytosis 10.3
41 hepatoportal sclerosis 10.2 F2 GPT
42 lymphoma 10.2
43 hepatitis d 10.2 F2 GPT
44 herpes simplex 10.2
45 paraquat poisoning 10.2 GPT SLC17A5
46 pyridoxine deficiency 10.2 GPT SLC17A5
47 autoimmune hepatitis 10.2
48 fatty liver disease, nonalcoholic 1 10.2 GPT SLC17A5
49 separation anxiety disorder 10.1 NBAS TSPO
50 antipyrine metabolism 10.1 ALB F2

Graphical network of the top 20 diseases related to Acute Liver Failure:



Diseases related to Acute Liver Failure
Sources

Symptoms & Phenotypes for Acute Liver Failure

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Sources

Drugs & Therapeutics for Acute Liver Failure

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Drugs for Acute Liver Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 209)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcysteine Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 616-91-1 12035
2
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
5
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
6
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
7
Pantoprazole Approved Phase 4 102625-70-7 4679
8
Haloperidol Approved Phase 4 52-86-8 3559
9
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
10
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
11 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
12 Gastrointestinal Agents Phase 4,Not Applicable
13 Protective Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
14 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
15 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
16 Antiviral Agents Phase 4,Phase 3,Phase 1,Not Applicable
17 Anti-Ulcer Agents Phase 4,Not Applicable
18 Antacids Phase 4,Not Applicable
19 Neurotransmitter Agents Phase 4,Phase 2,Not Applicable
20 Expectorants Phase 4,Phase 3,Phase 1,Not Applicable
21 N-monoacetylcystine Phase 4,Phase 3,Phase 1,Not Applicable
22 Antidotes Phase 4,Phase 3,Phase 1,Not Applicable
23 Antioxidants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
24 Free Radical Scavengers Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
25 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Not Applicable
26 Respiratory System Agents Phase 4,Phase 3,Phase 1,Not Applicable
27 Anti-Bacterial Agents Phase 4,Phase 2,Phase 1,Not Applicable
28 Antiemetics Phase 4
29 Methylprednisolone acetate Phase 4
30 Antineoplastic Agents, Hormonal Phase 4
31 Hormone Antagonists Phase 4
32 Neuroprotective Agents Phase 4
33 glucocorticoids Phase 4
34 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
35 Prednisolone acetate Phase 4
36 Anti-Inflammatory Agents Phase 4,Not Applicable
37 Hormones Phase 4
38 Autonomic Agents Phase 4,Not Applicable
39 Anti-HIV Agents Phase 4
40 Nucleic Acid Synthesis Inhibitors Phase 4
41 Anti-Retroviral Agents Phase 4
42 Reverse Transcriptase Inhibitors Phase 4
43 Proton Pump Inhibitors Phase 4
44 Haloperidol decanoate Phase 4
45 Antipsychotic Agents Phase 4
46 Tranquilizing Agents Phase 4
47 decanoic acid Phase 4
48 Dopamine Antagonists Phase 4
49 Psychotropic Drugs Phase 4
50 Dopamine Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 89)
# Name Status NCT ID Phase Drugs
1 Assessment of Coagulation Abnormalities in Acute on Chronic Liver Failure Patients Using Thromboelastography Unknown status NCT02757170 Phase 4
2 Steroids in Fulminant Hepatitis A in the Pediatric Age Group Completed NCT02375867 Phase 4 prednisolone;methylprednisolone
3 A Randomized Controlled Trial of Lamivudine in Acute Hepatitis B Completed NCT00380614 Phase 4 Lamivudine
4 Liver Function After Intravenous Methylprednisolone Administration Completed NCT03667157 Phase 4 every week IVMP therapy;very high doses IVMP therapy
5 Stress Ulcer Prophylaxis in the Intensive Care Unit Completed NCT02467621 Phase 4 Pantoprazole
6 Agents Intervening Against Delirium in Intensive Care Unit Recruiting NCT03392376 Phase 4 Haloperidol Injection
7 Study of N-Acetylcysteine in Acute Liver Failure (ALF) Terminated NCT00896025 Phase 4 N-acetylcysteine
8 Minocycline Administration During Human Liver Transplantation Withdrawn NCT02712775 Phase 4 Minocycline (yes/no);Placebo
9 N-acetylcysteine in Non-Acetaminophen Pediatric Acute Liver Failure Completed NCT00248625 Phase 3 N-acetylcysteine;Placebo
10 Randomized Study of Acetylcysteine in Patients With Acute Liver Failure Not Caused by Acetaminophen Completed NCT00004467 Phase 3 N-acetylcysteine (NAC);Placebo
11 The MARS® Albumin Dialysis System in Patients With Fulminant and Subfulminant Hepatic Failure Completed NCT00224705 Phase 3
12 MK-0524B Lipid Study (MK-0524B-063) Completed NCT00479882 Phase 3 Comparator: simvastatin;MK-0524A;Placebo;MK-0524B
13 Lipid Efficacy and Safety in Participants With Mixed Hyperlipidemia (MK-0524B-024) Completed NCT00289900 Phase 3 MK-0524A;Atorvastatin;Simvastatin
14 13C-Methacetin Breath Test for the Prediction of Outcome in in ALI or ALF Recruiting NCT02786836 Phase 2, Phase 3 13C-Methacetin
15 Study to Assess Safety and Efficacy of ELAD in Subjects With Severe Acute Alcoholic Hepatitis (sAAH) and Lille Score Failure Terminated NCT01829347 Phase 3
16 A Study to Evaluate Efficacy and Safety of Extended-Release Niacin + Laropiprant + Simvastatin in Participants With Primary Hypercholesterolemia or Mixed Dyslipidemia (MK-0524B-118) Terminated NCT01294683 Phase 3 Simvastatin;Extended Release (ER) niacin/laropiprant/simvastatin (N/LRPT/SIM);Extended Release (ER) niacin/laropiprant (N/LRPT);Placebo
17 Registry Protocol for Tracking Trial Subjects After VTI-206 Study Completion Withdrawn NCT01452295 Phase 2, Phase 3 ELAD (Extracorporeal Liver Assist System)
18 Cardiox Liver Function Test Pivotal Trial Withdrawn NCT02552901 Phase 3 0.1 mg/kg ICG Dose;0.5 mg/kg ICG dose
19 Therapeutic Efficacy of L-Ornithine L-Aspartate Infusion in Patients With Acute Liver Failure Unknown status NCT00470314 Phase 2 L-Ornithine L-Aspartate
20 Efficacy & Safety of ALF-5755 in Patients With Nonacetaminophen Severe Acute Hepatitis & Early Stage Acute Liver Failure Unknown status NCT01318525 Phase 2 ALF-5755;Saline solution (0.9% NaCl)
21 Phase I/II Study of Recombinant Human Hepatocyte Growth Factor in Fulminant Hepatic Failure Unknown status NCT00225901 Phase 1, Phase 2 Recombinant human hepatocyte growth factor
22 Molecular Adsorbent Recirculating System (MARS®) in Hypoxic Hepatitis Unknown status NCT01690845 Phase 2
23 Mesenchymal Stem Cells After Renal or Liver Transplantation Unknown status NCT01429038 Phase 1, Phase 2
24 Safety Study of Ornithine Phenylacetate to Treat Patients With Acute Liver Failure/Severe Acute Liver Injury Completed NCT01548690 Phase 2 Ornithine Phenylacetate
25 Emergency Use of OCR-002 in Acute Liver Failure Completed NCT01634230 Phase 2 OCR-002
26 Phase 2 Evaluation of the ELAD System in the Management of Acute Liver Failure Completed NCT00030225 Phase 2
27 Safety & Efficacy of the Extracorporeal Liver Assist Device (ELAD) System in Patients With Hepatic Insufficiency Completed NCT00771446 Phase 1, Phase 2
28 Safety and Efficacy of the ELAD System (ELAD) to Treat Acute Liver Failure (ALF) Terminated NCT01875874 Phase 2
29 Pharmacokinetic and Pharmacodynamic Study of IDN-6556 in ACLF Terminated NCT01937130 Phase 2 IDN-6556
30 Safety and Efficacy of the Extracorporeal Liver Assist Device (ELAD®) In Patients With Fulminant Hepatic Failure (FHF) Withdrawn NCT00832728 Phase 2
31 Hepatocyte Transplantation in Liver Failure Withdrawn NCT00805610 Phase 1, Phase 2
32 Macrophage Markers, Soluble CD163 (sCD163) and Soluble CD206 (sCD206) in Paracetamol Overdose Completed NCT03679442 Phase 1 N-acetylcysteine
33 A Study to Evaluate the Pharmacokinetics of Acetaminophen and Its Toxic Metabolites With 2 Formulations (Panadol and SafeTynadol) in Healthy Volunteers Completed NCT03451487 Phase 1 Panadol®;SafeTynadol®
34 Safety Study of Stemchymal® in Acute Liver Failure Not yet recruiting NCT03629015 Phase 1
35 A Phase 1 Study of LJPC-501 in Patients With Hepatorenal Syndrome Terminated NCT01906307 Phase 1 LJPC-501
36 Hepatocyte Transplantation for Acute Decompensated Liver Failure Withdrawn NCT01345565 Phase 1 human hepatocytes
37 Granulocyte Colony Stimulating Factor (G-CSF) in Acute Liver Failure and Alcoholic Hepatitis Unknown status NCT01341951 Not Applicable Granulocyte colony stimulating factor
38 Growth Factors and Hepatic Progenitor Cells in Acute Liver Failure Unknown status NCT01312220
39 Breath Test for Patients With Acute Liver Disease for Early Detection of the Need for Transplant or Recovery Unknown status NCT01435421
40 Removal of Protein Bound Uremic Toxins by Modified Plasma Separation and Adsorption Combined With Hemodialysis Unknown status NCT00375635 Not Applicable
41 Clinical and Basic Research of ETV Plus GM-CSF in Chronic Hepatitis B Patients Unknown status NCT03164889 Not Applicable Granulocyte Macrophage-colony Stimulating Factor;Entecavir
42 Mechanisms of N-acetylcysteine Mediated Vascular Adverse Effects Unknown status NCT01209455 Not Applicable Chlorphenamine and Ranitidine;Paracetamol;Paracetamol
43 Oxidative Stress and Microcirculation in Patient With Hepatic Failure Undergoing Liver Support Treatment Unknown status NCT00772252
44 Hepatitis B Antigen Kidney Graft Into Protective Level Hepatitis B Antibody Recipients Unknown status NCT02044588
45 Evaluation of Mechanisms Responsible for Coma in Patients Affected by Fulminant, Acute and Chronic Hepatic Failure Unknown status NCT01582087
46 Clinical and Basic Study for Pediatric Liver Transplantation Unknown status NCT02503384
47 High Volume Plasma Exchange in Children With Acute Liver Failure and Acute on Chronic Liver Failure Completed NCT02719210 Not Applicable Hypertonic 3% saline;Mannitol
48 A Multi-Center Group to Study Acute Liver Failure in Children Completed NCT00986648
49 A Study of the Effect of Plasmaexchange in Patients With Acute Liver Failure Completed NCT00950508 Not Applicable
50 Risk of Acute Liver Failure Among Patients With Type 2 Diabetes Exposed to Oral Antidiabetic Treatments Completed NCT01086293

Search NIH Clinical Center for Acute Liver Failure

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Acute Liver Failure cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Acute Liver Failure:
Hepatocyte transplantation for treatment of liver disorders
Hepatocyte transplantation for treatment of liver failure and inherited metabolic diseases
Liver cells for liver diseases
Embryonic/Adult Cultured Cells Related to Acute Liver Failure:
Hepatocytes PMIDs: 15239608 12777539 9580649 22789058 22167636
Liver cells PMIDs: 22532025 19295306 19796496 16454359 17060866
Sources

Genetic Tests for Acute Liver Failure

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Genetic tests related to Acute Liver Failure:

# Genetic test Affiliating Genes
1 Fulminant Hepatic Failure 29
Sources

Anatomical Context for Acute Liver Failure

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MalaCards organs/tissues related to Acute Liver Failure:

41
Liver, Brain, Testes, Bone, Bone Marrow, T Cells, Kidney
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Acute Liver Failure:
# Tissue Anatomical CompartmentCell Relevance
1 Liver Liver Lobule Hepatocytes Affected by disease, potential therapeutic candidate
Sources

Publications for Acute Liver Failure

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Articles related to Acute Liver Failure:

(show top 50) (show all 2473)
# Title Authors Year
1
Neutralization of CD95 ligand protects the liver against ischemia-reperfusion injury and prevents acute liver failure. ( 29374146 )
2018
2
Absolute quantitation of acetaminophen-modified human serum albumin in acute liver failure patients by LC-MS/MS. ( 29920820 )
2018
3
Challenges in the early diagnosis of patients with acute liver failure induced by amatoxin poisoning: Two case reports. ( 29979397 )
2018
4
Human liver organoids generated with single donor-derived multiple cells rescue mice from acute liver failure. ( 29321049 )
2018
5
Mesenchymal Stem Cell/Red Blood Cell-Inspired Nanoparticle Therapy in Mice with Carbon Tetrachloride-Induced Acute Liver Failure. ( 29943967 )
2018
6
Hepatitis A, cardiomyopathy, aplastic anemia, and acute liver failure: A devastating scenario. ( 29359844 )
2018
7
Acute Liver Failure due to Amanita phalloides Poisoning: Therapeutic Approach and Outcome. ( 29407307 )
2018
8
Acute Liver Failure of Indeterminate Etiology: A Comprehensive Systematic Approach by An Expert Committee to Establish Causality. ( 29946176 )
2018
9
Beyond KCH selection and options in acute liver failure. ( 29858744 )
2018
10
Liver transplantation for acute liver failure - a 30-year single center experience. ( 29848142 )
2018
11
Drug idiosyncrasy due to pirfenidone presenting as acute liver failure: Case report and mini-review of the literature. ( 29404521 )
2018
12
Case Report of Isoniazid-Related Acute Liver Failure Requiring Liver Transplantation. ( 29783726 )
2018
13
Acute Liver Failure in an Adolescent Male Induced by Human Herpesvirus 6 (HHV-6): A Case Report With Literature Review. ( 29390152 )
2018
14
Protective effect of Coptisine from Rhizoma Coptidis on LPS/D-GalN-induced acute liver failure in mice through up-regulating expression of miR-122. ( 29253766 )
2018
15
Acute liver failure due to liver parenchymal infiltration with acute myelogenous leukaemia in a patient with myelodysplastic syndrome. ( 29954762 )
2018
16
A good response to glucocorticoid for sub-acute liver failure: a case report. ( 29971256 )
2018
17
Liver maximum capacity (LiMAx) test as a helpful prognostic tool in acute liver failure with sepsis: a case report. ( 29925334 )
2018
18
Early Combination Therapy with Corticosteroid and Nucleoside Analogue Induces Rapid Resolution of Inflammation in Acute Liver Failure Due to Transient Hepatitis B Virus Infection. ( 29321429 )
2018
19
Noninvasive Intracranial Pressure Assessment in Acute Liver Failure. ( 29948998 )
2018
20
Hepatic Macrophages are the Cell Source of Hepatic Procalcitonin in Acute Liver Failure. ( 29913443 )
2018
21
Domino Liver Transplantation from a Child with Propionic Acidemia to a Child with Idiopathic Fulminant Hepatic Failure. ( 29725551 )
2018
22
A case of acute liver failure due to carfilzomib in multiple myeloma. ( 29969517 )
2018
23
Identification of key candidate genes and pathways in hepatitis B virus-associated acute liver failure by bioinformatical analysis. ( 29384847 )
2018
24
Acute Liver Failure Associated With Pomalidomide Therapy for Multiple Myeloma. ( 29907543 )
2018
25
Inappropriate use of the term of acute liver failure in a tertiary hospital. ( 29866512 )
2018
26
Macrophage-targeting and reactive oxygen species (ROS)-responsive nanopolyplexes mediate anti-inflammatory siRNA delivery against acute liver failure (ALF). ( 29855002 )
2018
27
Living Donor Liver Transplantation in Acute Liver Failure Patients with Grade IV Encephalopathy: Is Deep Hepatic Coma Still an Absolute Contraindication? A Successful Single-Center Experience. ( 29531210 )
2018
28
SCYL1 variants cause a syndrome with low I^-glutamyl-transferase cholestasis, acute liver failure, and neurodegeneration (CALFAN). ( 29419818 )
2018
29
Acute Liver Failure: Outcome and Value of Pediatric End-Stage Liver Disease Score in Pediatric Cases. ( 29851917 )
2018
30
Long-term outcome in patients with acute liver failure. ( 29927051 )
2018
31
Acute Liver Failure among Patients on Efavirenz-Based Antiretroviral Therapy. ( 29862098 )
2018
32
Dendritic cells with increased expression of suppressor of cytokine signaling 1(SOCS1) gene ameliorate lipopolysaccharide/d-galactosamine-induced acute liver failure. ( 29852455 )
2018
33
Comparison of Dynamic Changes Among Various Prognostic Scores in Viral Hepatitis-Related Acute Liver Failure. ( 29735790 )
2018
34
MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure. ( 28450389 )
2018
35
A study of association between regulatory polymorphism in the IL-10 gene promoter region and acute viral hepatitis, and acute liver failure. ( 30109600 )
2018
36
HepaRG-Progenitor Cell Derived Hepatocytes Cultured in Bioartificial Livers Are Protected from Healthy- and Acute Liver Failure-Plasma Induced Toxicity. ( 30110678 )
2018
37
Hepatoprotective effect of α-mangostin against lipopolysaccharide/d-galactosamine-induced acute liver failure in mice. ( 30119260 )
2018
38
The Effects of Conditioned Medium Derived from Mesenchymal Stem Cells Cocultured with Hepatocytes on Damaged Hepatocytes and Acute Liver Failure in Rats. ( 30123296 )
2018
39
Effect of tumor necrosis factor-α on the expression of the ammonia transporter Rhcg in the brain in mice with acute liver failure. ( 30134917 )
2018
40
Progress in mesenchymal stem cell-based therapy for acute liver failure. ( 30143052 )
2018
41
Cerebrovascular reactivity and cerebral perfusion of rats with acute liver failure: role of L-glutamine and asymmetric dimethylarginine in L-arginine-induced response. ( 30151828 )
2018
42
Herpes Simplex Virus-Associated Acute Liver Failure Often Goes Unrecognized. ( 30151988 )
2018
43
Uncommon Cause of Acute Liver Failure with Encephalopathy. ( 30186017 )
2018
44
Current and prospective therapies for acute liver failure. ( 30190075 )
2018
45
Hemophagocytic lymphohistiocytosis (HLH) presenting as fever of unknown origin and acute liver failure. ( 30191126 )
2018
46
A Novel Model to Predict 1-Month Risk of Transplant or Death in Hepatitis A-Related Acute Liver Failure. ( 30194739 )
2018
47
AMSC-derived exosomes alleviate lipopolysaccharide/d-galactosamine-induced acute liver failure by miR-17-mediated reduction of TXNIP/NLRP3 inflammasome activation in macrophages. ( 30197023 )
2018
48
ISMP Adverse Drug Reactions: Adalimumab-Induced Aseptic Meningitis Pill Desiccant -Induced Acute Hypoxic Respiratory Failure Rivastigmine Patch -Induced Angioedema Acute Liver Failure Due to Etodolac Severe Cognitive Impairment Due to High Free Valproic Acid Levels. ( 30210145 )
2018
49
Inhibition of RKIP aggravates thioacetamide-induced acute liver failure in mice. ( 30214516 )
2018
50
How to Define Acute Liver Failure Patients with Pre-Existing Liver Disease without Signs of Cirrhosis. ( 30227404 )
2018
Sources

Variations for Acute Liver Failure

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ClinVar genetic disease variations for Acute Liver Failure:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 POLG2 NM_007215.3(POLG2): c.544C> T (p.Arg182Trp) single nucleotide variant Likely pathogenic rs886037843 GRCh37 Chromosome 17, 62492543: 62492543
2 POLG2 NM_007215.3(POLG2): c.544C> T (p.Arg182Trp) single nucleotide variant Likely pathogenic rs886037843 GRCh38 Chromosome 17, 64496425: 64496425
3 MT-CO3 NC_012920.1: m.9355A> T single nucleotide variant Uncertain significance GRCh37 Chromosome MT, 9355: 9355
4 MT-CO3 NC_012920.1: m.9355A> T single nucleotide variant Uncertain significance GRCh38 Chromosome MT, 9355: 9355
Sources

Expression for Acute Liver Failure

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Search GEO for disease gene expression data for Acute Liver Failure.
Sources

Pathways for Acute Liver Failure

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Pathways related to Acute Liver Failure according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
FOXA2 and FOXA3 transcription factor networks 1
10.27 ALB F2
Sources

GO Terms for Acute Liver Failure

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Cellular components related to Acute Liver Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.43 ALB F2 F5
2 extracellular space GO:0005615 9.43 ALB F2 F5 GC GPT HGF
3 blood microparticle GO:0072562 9.33 ALB F2 GC
4 platelet alpha granule lumen GO:0031093 8.8 ALB F5 HGF

Biological processes related to Acute Liver Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.43 ALB F2 F5
2 hemostasis GO:0007599 9.32 F2 F5
3 positive regulation of reactive oxygen species metabolic process GO:2000379 9.16 F2 TSPO
4 anion transport GO:0006820 8.96 SLC17A5 TSPO
5 platelet degranulation GO:0002576 8.8 ALB F5 HGF

Molecular functions related to Acute Liver Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pyridoxal phosphate binding GO:0030170 8.62 ALB GPT
Sources

Sources for Acute Liver Failure

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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