MCID: ACT103
MIFTS: 53

Acute Lymphoblastic Leukemia, Childhood

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Acute Lymphoblastic Leukemia, Childhood

MalaCards integrated aliases for Acute Lymphoblastic Leukemia, Childhood:

Name: Acute Lymphoblastic Leukemia, Childhood 38
Childhood Acute Lymphoblastic Leukemia 12 53 15
Childhood Acute Lymphocytic Leukemia 12 53 15
Pediatric Acute Lymphoblastic Leukemia 53
Lymphoblastic Leukemia Acute Childhood 55
Leukemia, Lymphocytic, Acute, L1 73
Childhood All 53

Classifications:



External Ids:

Disease Ontology 12 DOID:0080144
NCIt 50 C3168
UMLS 73 C0023452

Summaries for Acute Lymphoblastic Leukemia, Childhood

NIH Rare Diseases : 53 Childhood acute lymphoblastic leukemia (ALL) is a type of cancer of the blood and bone marrow, and the most common type of cancer in children. In children with this condition, too many stem cells made by the bone marrow become lymphoblasts, B lymphocytes, or T lymphocytes. These cells do not function normally and have trouble fighting off infections. Signs and symptoms may include fever; easy bruising or bleeding; bone or joint pain; painless lumps in the neck, underarm, stomach, or groin; weakness; fatigue; and/or loss of appetite. Treatment depends on several factors and may include combination chemotherapy, targeted therapy, and/or stem cell transplant. On August 30 2017, Kymriah became the first gene therapy approved by the FDA. Kymriah is now an option for children and young adults up to 25 years old with B-Cell precursor ALL that has proven resistant to other treatments or has relapsed two or more times.

MalaCards based summary : Acute Lymphoblastic Leukemia, Childhood, also known as childhood acute lymphoblastic leukemia, is related to b-cell childhood acute lymphoblastic leukemia and leukemia, acute lymphoblastic. An important gene associated with Acute Lymphoblastic Leukemia, Childhood is PAX8-AS1 (PAX8 Antisense RNA 1), and among its related pathways/superpathways are Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics and Methotrexate Pathway, Pharmacokinetics. The drugs Vincristine and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and t cells, and related phenotypes are growth/size/body region and hematopoietic system

Disease Ontology : 12 An acute lymphocytic leukemia occuring during childhood.

Related Diseases for Acute Lymphoblastic Leukemia, Childhood

Diseases related to Acute Lymphoblastic Leukemia, Childhood via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 164)
# Related Disease Score Top Affiliating Genes
1 b-cell childhood acute lymphoblastic leukemia 34.5 ETV6 RUNX1
2 leukemia, acute lymphoblastic 30.1 ABCB1 ETV6 MME RUNX1 TPMT
3 childhood leukemia 30.1 ETV6 MTHFR RUNX1
4 central nervous system leukemia 30.0 MME RUNX1
5 acute lymphocytic leukemia 29.7 ASNS CDKN2A CDKN2B ETV6 GSTM1 MME
6 ewing's family of tumors 29.7 CDKN2A CDKN2B
7 t-cell childhood acute lymphocytic leukemia 12.4
8 lymphocytic leukemia 10.4
9 leukemia 10.4
10 body mass index quantitative trait locus 1 10.2
11 anxiety 10.2
12 hematopoietic stem cell transplantation 10.2
13 osteonecrosis 10.2
14 testicular disease 10.2
15 depression 10.2
16 methotrexate toxicity or dose selection 10.2 MTHFR SLC19A1
17 platelet disorder, familial, with associated myeloid malignancy 10.2 ETV6 RUNX1
18 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.2 ETV6 RUNX1
19 lymphoma, hodgkin, classic 10.1
20 nijmegen breakage syndrome 10.1
21 aging 10.1
22 upper thoracic spina bifida cystica 10.1 MTHFD1 MTHFR
23 cervicothoracic spina bifida cystica 10.1 MTHFD1 MTHFR
24 cervical spina bifida cystica 10.1 MTHFD1 MTHFR
25 lumbosacral spina bifida cystica 10.1 MTHFD1 MTHFR
26 thoracolumbosacral spina bifida cystica 10.1 MTHFD1 MTHFR
27 total spina bifida cystica 10.1 MTHFD1 MTHFR
28 upper thoracic spina bifida aperta 10.1 MTHFD1 MTHFR
29 thoracolumbosacral spina bifida aperta 10.1 MTHFD1 MTHFR
30 lumbosacral spina bifida aperta 10.1 MTHFD1 MTHFR
31 tenosynovial giant cell tumor 10.1 CDKN2A CDKN2B
32 cervical spina bifida aperta 10.1 MTHFD1 MTHFR
33 cervicothoracic spina bifida aperta 10.1 MTHFD1 MTHFR
34 scrotal carcinoma 10.1 CDKN2A CDKN2B
35 total spina bifida aperta 10.1 MTHFD1 MTHFR
36 fallopian tube endometrioid adenocarcinoma 10.1 CDKN2A MME
37 atypical neurofibroma 10.1 CDKN2A CDKN2B
38 retinoblastoma 10.1
39 down syndrome 10.1
40 wilms tumor 1 10.1
41 lymphoma, non-hodgkin, familial 10.1
42 lymphomatoid granulomatosis 10.1
43 oligodendroglioma 10.1
44 central nervous system disease 10.1
45 pancreatitis 10.1
46 nervous system disease 10.1
47 neuropathy 10.1
48 bone marrow necrosis 10.1
49 hypoxia 10.1
50 acute t cell leukemia 10.1

Graphical network of the top 20 diseases related to Acute Lymphoblastic Leukemia, Childhood:



Diseases related to Acute Lymphoblastic Leukemia, Childhood

Symptoms & Phenotypes for Acute Lymphoblastic Leukemia, Childhood

MGI Mouse Phenotypes related to Acute Lymphoblastic Leukemia, Childhood:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.07 ABCB1 ASNS CDKN2A ETV6 MTHFD1 MTHFR
2 hematopoietic system MP:0005397 10.02 ABCB1 ASNS CDKN2A CDKN2B ETV6 MTHFD1
3 homeostasis/metabolism MP:0005376 10 ABCB1 CDKN2A CDKN2B ETV6 MME MTHFD1
4 integument MP:0010771 9.76 CDKN2A CDKN2B ETV6 MME MTHFR NR3C1
5 liver/biliary system MP:0005370 9.5 ABCB1 CDKN2A MME MTHFR NR3C1 RUNX1
6 no phenotypic analysis MP:0003012 9.17 ABCB1 CDKN2A CDKN2B ETV6 MTHFR NR3C1

Drugs & Therapeutics for Acute Lymphoblastic Leukemia, Childhood

Drugs for Acute Lymphoblastic Leukemia, Childhood (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 400)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 57-22-7, 2068-78-2 5978
2
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 59-05-2, 1959-05-2 126941
3
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1177-87-3
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-02-2 5743
5
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-05-9 6006 143
6
Idarubicin Approved Phase 4,Phase 3,Phase 2,Not Applicable 58957-92-9 42890
7
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 20830-81-3 30323
8
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 147-94-4 6253
9
Pegaspargase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 130167-69-0
10
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 23214-92-8 31703
11
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 6055-19-2, 50-18-0 2907
12
Thioguanine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 154-42-7 2723601
13
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 75607-67-9, 21679-14-1 30751
14
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2921-57-5
15
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
16
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
17
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 302-25-0
18
Thiotepa Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 52-24-4 5453
19
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 135968-09-1
20
Oprelvekin Approved, Investigational Phase 4 145941-26-0
21
Budesonide Approved Phase 4 51333-22-3 63006 5281004
22
Heparin Approved, Investigational Phase 4,Not Applicable 9005-49-6 772 46507594
23
Bivalirudin Approved, Investigational Phase 4 128270-60-0 16129704
24
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
25
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
26
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 59-30-3 6037
27
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 1406-16-2
28
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3 50-14-6 5280793
29
Serine Approved, Nutraceutical Phase 4 56-45-1 5951
30
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
31
Doxil Approved June 1999 Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 31703
32
Prednisolone hemisuccinate Experimental Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2920-86-7
33 6-Mercaptopurine Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
34 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
35 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
37 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
38 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
39
protease inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
40 Vitamin B Complex Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
41 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 BB 1101 Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
44 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
45 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
47 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
48 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
49 Antimitotic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
50 Antiemetics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 498)
# Name Status NCT ID Phase Drugs
1 The GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia Unknown status NCT00846703 Phase 4 6-mercaptopurine, Methotrexate;6-mercaptopurine, Methotrexate, Vincristine, Dexamethasone
2 Treatment Protocol of Children With Philadelphia Chromosome Negative High Risk Acute Lymphoblastic Leukemia Unknown status NCT01990807 Phase 4 Idarubicin(IDA)
3 Poly(Ethylene Glycol)(PEG)-Asparaginase During Two Treatment Courses Unknown status NCT00192673 Phase 4 PEG-asparaginase
4 Malaysia-Singapore Acute Lymphoblastic Leukemia 2010 Study Unknown status NCT02894645 Phase 4 Prednisolone;Dexamethasone;L-Asparaginase;Vincristine;Methotrexate;Daunorubicin;Doxorubicin;Cyclophosphamide;Cytarabine;6-Mercaptopurine;Thioguanine;Fludarabine;Imatinib
5 Effect of rhIL-11 in Patients With Thrombocytopenia for Childhood ALL Completed NCT02314273 Phase 4 rhIL-11
6 Pulses of Vincristine and Dexamethasone in BFM Protocols for Children With Acute Lymphoblastic Leukemia Completed NCT00411541 Phase 4 vincristine;dexamethasone
7 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4 cyclophosphamide;thiotepa
8 Study on Two Different Formulations of 6-mercaptopurine. Tablet Versus Oral Liquid Recruiting NCT01906671 Phase 4 Xaluprine;Puri-Nethol
9 Inhaled Steroids for Pediatric Asthma at Pediatric Emergency Medicine Discharge Recruiting NCT03369847 Phase 4 budesonide, beclomethasone
10 Study Comparing Bivalirudin Versus Heparin in Neonatal and Pediatric ECMO Recruiting NCT03318393 Phase 4 Bivalirudin;Unfractionated heparin
11 Intranasal Ketamine for Anxiolysis in Pediatric Emergency Department Patients Recruiting NCT03043430 Phase 4 Ketamine 100 MG/ML;Midazolam 5 MG/ML
12 Identification of New Immune Factors Specific of Relapse in Childhood B Lineage Acute Lymphoblastic Leukemia Recruiting NCT02618109 Phase 4
13 A Randomized Phase IV Control Trial of Single High Dose Oral Vitamin D3 in Pediatric Patients Undergoing HSCT Enrolling by invitation NCT03176849 Phase 4
14 Allogeneic Stem Cell Transplantation in Children and Adolescents With Acute Lymphoblastic Leukaemia Unknown status NCT01423747 Phase 3 VP16;VP16, ATG;Fludarabine, OKT3, Treosulfan, Thiotepa;VP16, ATG
15 ALL-SCT BFM International- HSCT in Children and Adolescents With ALL Unknown status NCT01423500 Phase 3 VP16;VP16, ATG;Fludarabine, OKT3, Treosulfan, Thiotepa;VP16, ATG
16 Hormone Therapy Plus Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia Unknown status NCT00003437 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;pegaspargase;prednisolone;thioguanine;vincristine sulfate
17 Combination Chemotherapy in Treating Children With Relapsed Acute Lymphocytic Leukemia Unknown status NCT00002499 Phase 2, Phase 3 asparaginase;cytarabine;daunorubicin hydrochloride;dexamethasone;methotrexate;prednisone;vincristine sulfate
18 Risk-Adjusted Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia Unknown status NCT00764907 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate;vindesine
19 Tacrolimus and Methotrexate With or Without Sirolimus in Preventing Graft-Versus-Host Disease in Young Patients Undergoing Donor Stem Cell Transplant for Acute Lymphoblastic Leukemia in Complete Remission Unknown status NCT00382109 Phase 3 thiotepa;cyclophosphamide;tacrolimus;methotrexate;sirolimus
20 Combination Chemotherapy Plus Steroid Therapy in Treating Children With Acute Lymphoblastic Leukemia or Lymphoblastic Non-Hodgkin's Lymphoma Unknown status NCT00003728 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;leucovorin calcium;mercaptopurine;methotrexate;methylprednisolone;mitoxantrone hydrochloride;prednisolone;therapeutic hydrocortisone;thioguanine;vincristine sulfate;vindesine
21 Combination Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia Completed NCT00002816 Phase 3 cytarabine;dexamethasone;etoposide;idarubicin;ifosfamide;leucovorin calcium;mesna;pegaspargase;therapeutic hydrocortisone;thioguanine;vincristine sulfate;Methotrexate
22 ALL2008 Protocol for Childhood Acute Lymphoblastic Leukemia (ALL) - 6MP Consolidation Therapy Completed NCT00816049 Phase 3 6MPindividualized;6MPfixed
23 ALL2008 Protocol for Childhood Acute Lymphoblastic Leukemia Intermittent Versus Continuous PEG Asparaginase Completed NCT00819351 Phase 3 PEG Asparaginase at six weeks interval;PEG Asparaginase at two weeks interval
24 Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia Completed NCT00005585 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;leucovorin calcium;mercaptopurine;methotrexate;pegaspargase;thioguanine;vincristine sulfate
25 Zometa Study in Pediatric Acute Lymphoblastic Leukemia Completed NCT01656512 Phase 3 zolendronic acid;calcium & vitamin D
26 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed NCT00103285 Phase 3 doxorubicin hydrochloride;cytarabine;dexamethasone;pegaspargase;methotrexate;leucovorin calcium;mercaptopurine;cyclophosphamide;thioguanine;vincristine sulfate
27 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Children With Acute Lymphoblastic Leukemia Completed NCT00022737 Phase 3 asparaginase;cyclophosphamide;cyclosporine;cytarabine;daunorubicin hydrochloride;dexamethasone;etoposide;ifosfamide;imatinib mesylate;leucovorin calcium;mercaptopurine tablet;methotrexate;pegaspargase;vincristine sulfate
28 Combination Chemotherapy Based on Risk of Relapse in Treating Young Patients With Acute Lymphoblastic Leukemia Completed NCT00613457 Phase 3 dexamethasone;asparaginase;Asparaginase;cyclophosphamide;cytarabine;daunorubicin;doxorubicin;Etoposide;Ifosfamide;mercaptopurine;Methotrexate;prednisone;thioguanine;Vincristine;Vindesine
29 A Severity-Adapted Clinical Trial of Diminished Bone Mineral Density in Acute Lymphoblastic Leukemia Survivors Completed NCT00186901 Phase 3 Calcium carbonate (Tums), vitamin D
30 Comparison of Different Combination Chemotherapy Regimens in Treating Children With Acute Lymphoblastic Leukemia Completed NCT00005945 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;pegaspargase;thioguanine;vincristine sulfate
31 Combination Chemotherapy in Treating Young Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia Completed NCT00967057 Phase 3 asparaginase;dexamethasone;idarubicin;methotrexate;mitoxantrone hydrochloride;pegaspargase;vincristine sulfate
32 Comparison of Different Combination Chemotherapy Regimens in Treating Infants With Acute Lymphoblastic Leukemia Completed NCT00015873 Phase 3 asparaginase;cytarabine;mercaptopurine;methotrexate;prednisolone;vincristine sulfate
33 Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia Completed NCT00005596 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;leucovorin calcium;mercaptopurine;methotrexate;pegaspargase;thioguanine;vincristine sulfate
34 Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia Completed NCT00005603 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate
35 Low-Dose or High-Dose Vincristine and Combination Chemotherapy in Treating Young Patients With Relapsed B-Cell Acute Lymphoblastic Leukemia Completed NCT00381680 Phase 3 vincristine sulfate;prednisone;doxorubicin hydrochloride;pegaspargase;cytarabine;methotrexate;dexamethasone;etoposide;cyclophosphamide;leucovorin calcium;asparaginase;mercaptopurine
36 Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia Completed NCT00002744 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;pegaspargase;prednisone;therapeutic hydrocortisone;thioguanine;vincristine sulfate
37 Combination Chemotherapy in Treating Children With Acute Lymphocytic Leukemia Completed NCT00002812 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;idarubicin;mercaptopurine;methotrexate;pegaspargase;prednisone;thioguanine;vincristine sulfate
38 Combination Chemotherapy Based on Risk of Relapse in Treating Young Patients With Acute Lymphoblastic Leukemia Completed NCT00430118 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate;vindesine
39 Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed NCT00720109 Phase 2, Phase 3 Asparaginase;Cyclophosphamide;Cytarabine;Dasatinib;Daunorubicin Hydrochloride;Dexamethasone;Etoposide;Hydrocortisone Sodium Succinate;Ifosfamide;Leucovorin Calcium;Mercaptopurine;Methotrexate;Methylprednisolone;Pegaspargase;Prednisone;Vincristine Sulfate
40 Combination Chemotherapy With or Without Lestaurtinib in Treating Younger Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed NCT00557193 Phase 3 Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin Hydrochloride;Dexamethasone;Etoposide;Lestaurtinib;Leucovorin Calcium;Mercaptopurine;Methotrexate;Methylprednisolone;Pegaspargase;Prednisone;Therapeutic Hydrocortisone;Vincristine Sulfate
41 Dexamethasone Compared With Prednisone During Induction Therapy and MTX With or Without Leucovorin During Maintenance Therapy in Treating Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia Completed NCT00075725 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;pegaspargase;prednisone;thioguanine;vincristine sulfate
42 Combination Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia or Advanced Lymphoblastic Non-Hodgkin's Lymphoma Completed NCT01230983 Phase 3 asparaginase;cytarabine;dexrazoxane hydrochloride;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;prednisone;therapeutic hydrocortisone;vincristine sulfate
43 Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant Completed NCT01305200 Phase 3 supersaturated calcium phosphate rinse
44 Bone Marrow Transplantation in Treating Patients With Leukemia, Myelodysplasia, or Lymphoblastic Lymphoma Completed NCT00003187 Phase 2, Phase 3 cyclophosphamide;cyclosporine;cytarabine;methotrexate;methylprednisolone
45 Personalized Information or Basic Information in Helping Patients Make Decisions About Participating in a Clinical Trial Completed NCT00750009 Phase 3
46 Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation Completed NCT00045292 Phase 3 acyclovir;acyclovir sodium;valacyclovir
47 Bone Marrow Transplantation in Treating Patients With Acute Leukemia in First or Second Remission Completed NCT00002534 Phase 3 cyclophosphamide;cytarabine;methylprednisolone;thiotepa
48 Treatment of Bone Marrow to Prevent Graft-Versus-Host Disease in Patients With Acute or Chronic Leukemia Undergoing Bone Marrow Transplantation Completed NCT00004255 Phase 2, Phase 3 cyclophosphamide;fludarabine phosphate;methylprednisolone;tacrolimus
49 Levofloxacin in Preventing Infection in Young Patients With Acute Leukemia Receiving Chemotherapy or Undergoing Stem Cell Transplantation Completed NCT01371656 Phase 3 levofloxacin
50 TITLE:Less Intensive Therapy for Children With Non-Hodgkin's Lymphoma Completed NCT00002757 Phase 3 cyclophosphamide;cytarabine;doxorubicin hydrochloride;etoposide;methotrexate;prednisolone;prednisone;therapeutic hydrocortisone;vincristine sulfate

Search NIH Clinical Center for Acute Lymphoblastic Leukemia, Childhood

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Stem-cell-based therapeutic approaches for Acute Lymphoblastic Leukemia, Childhood:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Acute Lymphoblastic Leukemia, Childhood:
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Acute Lymphoblastic Leukemia, Childhood

Anatomical Context for Acute Lymphoblastic Leukemia, Childhood

MalaCards organs/tissues related to Acute Lymphoblastic Leukemia, Childhood:

41
Bone, Bone Marrow, T Cells, B Cells, Myeloid, Endothelial, Brain

Publications for Acute Lymphoblastic Leukemia, Childhood

Articles related to Acute Lymphoblastic Leukemia, Childhood:

(show top 50) (show all 1239)
# Title Authors Year
1
Insulin-dependent diabetes: A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia. ( 30216644 )
2019
2
Low Incidence of Osteonecrosis in Childhood Acute Lymphoblastic Leukemia Treated With ALL-97 and ALL-02 Study of Japan Association of Childhood Leukemia Study Group. ( 29360413 )
2018
3
Long non-coding RNA PAX8-AS1 polymorphisms increase the risk of childhood acute lymphoblastic leukemia. ( 29435279 )
2018
4
Anti-leukemic treatment-induced neurotoxicity in long-term survivors of childhood acute lymphoblastic leukemia: impact of reduced central nervous system radiotherapy and intermediate- to high-dose methotrexate. ( 29424258 )
2018
5
Living on a farm, contact with farm animals and pets, and childhood acute lymphoblastic leukemia: pooled and meta-analyses from the Childhood Leukemia International Consortium. ( 29663688 )
2018
6
Advanced parental age as risk factor for childhood acute lymphoblastic leukemia: results from studies of the Childhood Leukemia International Consortium. ( 29761423 )
2018
7
Hematopoietic Stem Cell Transplantation for Childhood Acute Lymphoblastic Leukemia and the Role of MRD: A Single Centre Experience from India. ( 29398798 )
2018
8
Treating childhood acute lymphoblastic leukemia in a country with no pediatric hematologist/oncologist: a Belize/Mérida joint venture. ( 30504207 )
2018
9
The contribution of XRCC3 genotypes to childhood acute lymphoblastic leukemia. ( 30532590 )
2018
10
Prevalence and Risk Factors for Arterial Hypertension Development in Childhood Acute Lymphoblastic Leukemia Survivors. ( 30475300 )
2018
11
Involvement of miRNA polymorphism in mucositis development in childhood acute lymphoblastic leukemia treatment. ( 30479191 )
2018
12
Early vs. late MRD response- and risk-based treatment intensification of childhood acute lymphoblastic leukemia: a prospective pilot study from Saudi Arabia. ( 30479872 )
2018
13
Novel susceptibility variants at the ERG locus for childhood acute lymphoblastic leukemia in Hispanics. ( 30510082 )
2018
14
Very long intergenic non-coding RNA transcripts and expression profiles are associated to specific childhood acute lymphoblastic leukemia subtypes. ( 30440012 )
2018
15
Correspondence: Osteonecrosis in childhood acute lymphoblastic leukemia: a retrospective cohort study of the Italian Association of Pediatric Haemato-Oncology (AIEOP). ( 30442887 )
2018
16
Panel-based next-generation sequencing identifies prognostic and actionable genes in childhood acute lymphoblastic leukemia and is suitable for clinical sequencing. ( 30446805 )
2018
17
Acquired Platythorax, or Anteroposterior Flattening of the Chest Wall, as a Late Complication of Cyclophosphamide Treatment for Childhood Acute Lymphoblastic Leukemia, Presenting in a Young Man with Respiratory Failure. ( 30393370 )
2018
18
Late Effects of Therapy in Childhood Acute Lymphoblastic Leukemia Survivors. ( 30398158 )
2018
19
Characteristics and Therapeutic Targeting of Minimal Residual Disease in Childhood Acute Lymphoblastic Leukemia. ( 30411264 )
2018
20
A mathematical model of white blood cell dynamics during maintenance therapy of childhood acute lymphoblastic leukemia. ( 30357334 )
2018
21
Treatment of childhood acute lymphoblastic leukemia with delayed first intrathecal therapy and omission of prophylactic cranial irradiation: Results of the TPOG-ALL-2002 study. ( 30303520 )
2018
22
Methotrexate polyglutamate levels and co-distributions in childhood acute lymphoblastic leukemia maintenance therapy. ( 30324220 )
2018
23
Prognostic Implication of MIF Gene Expression in Childhood Acute Lymphoblastic Leukemia. ( 30274020 )
2018
24
Birth Weight and Risk of Childhood Acute Lymphoblastic Leukemia in Arizona, Illinois, and Kentucky. ( 30285262 )
2018
25
Humoral immune response of childhood acute lymphoblastic leukemia survivors against the measles, mumps, and rubella vaccination. ( 29614919 )
2018
26
Allergies and Childhood Acute Lymphoblastic Leukemia: A Case-Control Study and Meta-analysis. ( 30068517 )
2018
27
Psychological risk in long-term survivors of childhood acute lymphoblastic leukemia and its association with functional health status: A PETALE cohort study. ( 30084222 )
2018
28
Late effects in survivors of childhood acute lymphoblastic leukemia in the context of selected gene polymorphisms. ( 30111348 )
2018
29
ETV6/RUNX1-positive childhood acute lymphoblastic leukemia in China: excellent prognosis with improved BFM protocol. ( 30115129 )
2018
30
Long-term results of the risk-stratified treatment of childhood acute lymphoblastic leukemia in China. ( 30133806 )
2018
31
Sanguinarine suppresses growth and induces apoptosis in childhood acute lymphoblastic leukemia. ( 30187808 )
2018
32
Genetic risk factors for VIPN in childhood acute lymphoblastic leukemia patients identified using whole-exome sequencing. ( 30191766 )
2018
33
Maternal Red Blood Cell Folate and Infant Vitamin B12 Status Influence Methylation of Genes Associated with Childhood Acute Lymphoblastic Leukemia. ( 30192066 )
2018
34
Pharmacogenomic markers of glucocorticoid response in the initial phase of remission induction therapy in childhood acute lymphoblastic leukemia. ( 30210047 )
2018
35
G9a Correlates with VLA-4 Integrin and Influences the Migration of Childhood Acute Lymphoblastic Leukemia Cells. ( 30213075 )
2018
36
Child symptoms, parent behaviors, and family strain in long-term survivors of childhood acute lymphoblastic leukemia. ( 29772082 )
2018
37
ETV6/RUNX1-positive childhood acute lymphoblastic leukemia (ALL): The spectrum of clonal heterogeneity and its impact on prognosis. ( 29778230 )
2018
38
Brain Activity Associated With Attention Deficits Following Chemotherapy for Childhood Acute Lymphoblastic Leukemia. ( 29790971 )
2018
39
Involvement of SNPs in miR-3117 and miR-3689d2 in childhood acute lymphoblastic leukemia risk. ( 29796161 )
2018
40
Implementation of Medication Safety Practice in Childhood Acute Lymphoblastic Leukemia Treatment ( 29801409 )
2018
41
Data for the measurement of serum vitamin D metabolites in childhood acute lymphoblastic leukemia survivors. ( 29900323 )
2018
42
BMI1 enhancer polymorphism underlies chromosome 10p12.31 association with childhood acute lymphoblastic leukemia. ( 29923177 )
2018
43
Leukocyte Telomere Length Shortening, hTERT Genetic Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia ( 29936725 )
2018
44
Brain Network Connectivity and Executive Function in Long-Term Survivors of Childhood Acute Lymphoblastic Leukemia. ( 29936880 )
2018
45
Incidence and Risk Factors for Hypertension During Childhood Acute Lymphoblastic Leukemia Therapy. ( 29941701 )
2018
46
BCL2L12 improves risk stratification and prediction of BFM-chemotherapy response in childhood acute lymphoblastic leukemia. ( 30016275 )
2018
47
Evolution of neurocognitive function in long-term survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only. ( 29484542 )
2018
48
Vitamin D nutritional status and bone turnover markers in childhood acute lymphoblastic leukemia survivors: A PETALE study. ( 29503055 )
2018
49
Behavioral symptoms and psychiatric disorders in child and adolescent long-term survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only. ( 29521470 )
2018
50
Influence of IL15 gene variations on the clinical features, treatment response and risk of developing childhood acute lymphoblastic leukemia in Latvian population. ( 29528261 )
2018

Variations for Acute Lymphoblastic Leukemia, Childhood

Copy number variations for Acute Lymphoblastic Leukemia, Childhood from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 250737 9 21967751 21994490 Deletion CDKN2A pediatric acute lymphoblastic leukemia

Expression for Acute Lymphoblastic Leukemia, Childhood

Search GEO for disease gene expression data for Acute Lymphoblastic Leukemia, Childhood.

Pathways for Acute Lymphoblastic Leukemia, Childhood

Pathways related to Acute Lymphoblastic Leukemia, Childhood according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.39 GSTM1 TPMT
2
Show member pathways
9.92 ABCB1 SLC19A1

GO Terms for Acute Lymphoblastic Leukemia, Childhood

Biological processes related to Acute Lymphoblastic Leukemia, Childhood according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 one-carbon metabolic process GO:0006730 9.46 MTHFD1 MTHFR
2 negative regulation of phosphorylation GO:0042326 9.43 CDKN2A CDKN2B
3 hematopoietic stem cell proliferation GO:0071425 9.4 ETV6 RUNX1
4 replicative senescence GO:0090399 9.37 CDKN2A MME
5 methionine biosynthetic process GO:0009086 9.32 MTHFD1 MTHFR
6 tetrahydrofolate interconversion GO:0035999 9.26 MTHFD1 MTHFR
7 methionine metabolic process GO:0006555 9.16 MTHFD1 MTHFR
8 obsolete negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031658 8.96 CDKN2A CDKN2B
9 folic acid metabolic process GO:0046655 8.8 MTHFD1 MTHFR SLC19A1

Molecular functions related to Acute Lymphoblastic Leukemia, Childhood according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 8.62 CDKN2A CDKN2B

Sources for Acute Lymphoblastic Leukemia, Childhood

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
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49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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