MCID: ACT103
MIFTS: 48

Acute Lymphoblastic Leukemia, Childhood

Categories: Rare diseases, Cancer diseases, Immune diseases, Blood diseases

Aliases & Classifications for Acute Lymphoblastic Leukemia, Childhood

MalaCards integrated aliases for Acute Lymphoblastic Leukemia, Childhood:

Name: Acute Lymphoblastic Leukemia, Childhood 38
Childhood Acute Lymphocytic Leukemia 12 53 15
Childhood Acute Lymphoblastic Leukemia 12 53
Pediatric Acute Lymphoblastic Leukemia 53
Lymphoblastic Leukemia Acute Childhood 55
Leukemia, Lymphocytic, Acute, L1 73
Childhood All 53

Classifications:



External Ids:

Disease Ontology 12 DOID:0080144
NCIt 50 C3168
UMLS 73 C0023452

Summaries for Acute Lymphoblastic Leukemia, Childhood

NIH Rare Diseases : 53 Childhood acute lymphoblastic leukemia (ALL) is a type of cancer of the blood and bone marrow, and the most common type of cancer in children. In children with this condition, too many stem cells made by the bone marrow become lymphoblasts, B lymphocytes, or T lymphocytes. These cells do not function normally and have trouble fighting off infections. Signs and symptoms may include fever; easy bruising or bleeding; bone or joint pain; painless lumps in the neck, underarm, stomach, or groin; weakness; fatigue; and/or loss of appetite. Treatment depends on several factors and may include combination chemotherapy, targeted therapy, and/or stem cell transplant. On August 30 2017, Kymriah became the first gene therapy approved by the FDA. Kymriah is now an option for children and young adults up to 25 years old with B-Cell precursor ALL that has proven resistant to other treatments or has relapsed two or more times.

MalaCards based summary : Acute Lymphoblastic Leukemia, Childhood, also known as childhood acute lymphocytic leukemia, is related to b-cell childhood acute lymphoblastic leukemia and lymphoblastic leukemia. An important gene associated with Acute Lymphoblastic Leukemia, Childhood is PAX8-AS1 (PAX8 Antisense RNA 1), and among its related pathways/superpathways are One carbon pool by folate and Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics. The drugs Cytarabine and Daunorubicin have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and t cells, and related phenotypes are hematopoietic system and integument

Disease Ontology : 12 An acute lymphocytic leukemia occuring during childhood.

Related Diseases for Acute Lymphoblastic Leukemia, Childhood

Diseases related to Acute Lymphoblastic Leukemia, Childhood via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 b-cell childhood acute lymphoblastic leukemia 34.9 ETV6 RUNX1
2 lymphoblastic leukemia 29.8 CDKN2A ETV6 RUNX1
3 leukemia, acute lymphoblastic 28.8 ABCB1 ETV6 MME RUNX1 TPMT
4 acute lymphocytic leukemia 25.7 ASNS CDKN2A CDKN2B ETV6 GSTM1 MME
5 t-cell childhood acute lymphocytic leukemia 12.2
6 platelet disorder, familial, with associated myeloid malignancy 10.7 ETV6 RUNX1
7 methotrexate toxicity or dose selection 10.6 MTHFR SLC19A1
8 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.6 ETV6 RUNX1
9 central nervous system leukemia 10.5 MME RUNX1
10 tenosynovial giant cell tumor 10.4 CDKN2A CDKN2B
11 upper thoracic spina bifida cystica 10.4 MTHFD1 MTHFR
12 cervicothoracic spina bifida cystica 10.4 MTHFD1 MTHFR
13 cervical spina bifida cystica 10.4 MTHFD1 MTHFR
14 lumbosacral spina bifida cystica 10.4 MTHFD1 MTHFR
15 thyroid lymphoma 10.4 CDKN2A CDKN2B
16 thoracolumbosacral spina bifida cystica 10.4 MTHFD1 MTHFR
17 total spina bifida cystica 10.4 MTHFD1 MTHFR
18 upper thoracic spina bifida aperta 10.4 MTHFD1 MTHFR
19 thoracolumbosacral spina bifida aperta 10.3 MTHFD1 MTHFR
20 scrotal carcinoma 10.3 CDKN2A CDKN2B
21 lumbosacral spina bifida aperta 10.3 MTHFD1 MTHFR
22 cervical spina bifida aperta 10.3 MTHFD1 MTHFR
23 cervicothoracic spina bifida aperta 10.3 MTHFD1 MTHFR
24 atypical neurofibroma 10.3 CDKN2A CDKN2B
25 pediatric osteosarcoma 10.3 MTHFR SLC19A1
26 total spina bifida aperta 10.3 MTHFD1 MTHFR
27 fallopian tube endometrioid adenocarcinoma 10.3 CDKN2A MME
28 childhood leukemia 10.3 ETV6 MTHFR RUNX1
29 hemifacial spasm 10.3 MTHFR TYMS
30 differentiated thyroid carcinoma 10.1 CDKN2A ETV6 MTHFR
31 leukemia 10.1
32 ewing's family of tumors 10.0 CDKN2A CDKN2B
33 adult acute lymphocytic leukemia 10.0 CDKN2B TYMS
34 myelomeningocele 10.0 MTHFD1 MTHFR SLC19A1
35 oral leukoplakia 10.0 CDKN2A GSTM1
36 precursor t-cell acute lymphoblastic leukemia 9.9 ASNS CDKN2A CDKN2B ETV6
37 cholangiolocellular carcinoma 9.8 ABCB1 CDKN2A
38 acute t cell leukemia 9.8
39 papilloma 9.8 CDKN2A CDKN2B TYMS
40 meningeal melanocytoma 9.6 CDKN2A MME
41 plasmablastic lymphoma 9.6 ABCB1 CDKN2A
42 leukemia, acute lymphoblastic 3 9.4 CDKN2A CDKN2B ETV6 MME RUNX1
43 leukemia, chronic myeloid 9.4 ABCB1 CDKN2B ETV6 RUNX1
44 myelodysplastic syndrome 9.3 CDKN2B ETV6 GSTM1 RUNX1
45 mucositis 9.3 ABCB1 MTHFR TYMS
46 neural tube defects 9.2 MTHFD1 MTHFR SLC19A1 TYMS
47 hematologic cancer 8.9 ABCB1 CDKN2B ETV6 MME RUNX1
48 leukemia, acute myeloid 8.9 ABCB1 CDKN2B ETV6 MME RUNX1
49 acute leukemia 8.7 ABCB1 ETV6 GSTM1 MTHFR RUNX1

Graphical network of the top 20 diseases related to Acute Lymphoblastic Leukemia, Childhood:



Diseases related to Acute Lymphoblastic Leukemia, Childhood

Symptoms & Phenotypes for Acute Lymphoblastic Leukemia, Childhood

MGI Mouse Phenotypes related to Acute Lymphoblastic Leukemia, Childhood:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.61 TPMT ABCB1 ASNS CDKN2A CDKN2B ETV6
2 integument MP:0010771 9.17 CDKN2A CDKN2B ETV6 MME MTHFR RUNX1

Drugs & Therapeutics for Acute Lymphoblastic Leukemia, Childhood

Drugs for Acute Lymphoblastic Leukemia, Childhood (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 375)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 147-94-4 6253
2
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 20830-81-3 30323
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-02-2 5743
4
Idarubicin Approved Phase 4,Phase 3,Phase 2,Not Applicable 58957-92-9 42890
5
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1959-05-2, 59-05-2 126941
6
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2068-78-2, 57-22-7 5978
7
Pegaspargase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 130167-69-0
8
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-18-0, 6055-19-2 2907
9
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 135968-09-1
10
Thiotepa Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 52-24-4 5453
11
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 23214-92-8 31703
12
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 21679-14-1, 75607-67-9 30751
13
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
14
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
15
Thioguanine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 154-42-7 2723601
16
Oprelvekin Approved, Investigational Phase 4 145941-26-0
17
Budesonide Approved Phase 4 51333-22-3 63006 5281004
18
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
19
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
20
Bivalirudin Approved, Investigational Phase 4 128270-60-0 16129704
21
Heparin Approved, Investigational Phase 4,Not Applicable 9005-49-6 772 46507594
22
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 59-30-3 6037
23
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-05-9 143 6006
24
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3 50-14-6 5280793
25
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 1406-16-2
26
Serine Approved, Nutraceutical Phase 4 56-45-1 5951
27
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 6221 5280795
28
Doxil Approved June 1999 Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 31703
29 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
31
asparaginase Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
32 BB 1101 Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
33 Dexamethasone acetate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1177-87-3
34 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
35 Antibodies Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
36
Ethylene Phase 4 74-85-1 6325
37 Immunoglobulins Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
38 Antiemetics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
39 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
40 Antimitotic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Antineoplastic Agents, Phytogenic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
47 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
49 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
50 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 487)
# Name Status NCT ID Phase Drugs
1 Treatment Protocol of Children With Philadelphia Chromosome Negative High Risk Acute Lymphoblastic Leukemia Unknown status NCT01990807 Phase 4 Idarubicin(IDA)
2 Poly(Ethylene Glycol)(PEG)-Asparaginase During Two Treatment Courses Unknown status NCT00192673 Phase 4 PEG-asparaginase
3 Effect of rhIL-11 in Patients With Thrombocytopenia for Childhood ALL Completed NCT02314273 Phase 4 rhIL-11
4 Pulses of Vincristine and Dexamethasone in BFM Protocols for Children With Acute Lymphoblastic Leukemia Completed NCT00411541 Phase 4 vincristine;dexamethasone
5 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4 cyclophosphamide;thiotepa
6 The GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia Recruiting NCT00846703 Phase 4 6-mercaptopurine, Methotrexate;6-mercaptopurine, Methotrexate, Vincristine, Dexamethasone
7 Study on Two Different Formulations of 6-mercaptopurine. Tablet Versus Oral Liquid Recruiting NCT01906671 Phase 4 Xaluprine;Puri-Nethol
8 Inhaled Steroids for Pediatric Asthma at Pediatric Emergency Medicine Discharge Recruiting NCT03369847 Phase 4 budesonide, beclomethasone
9 Malaysia-Singapore Acute Lymphoblastic Leukemia 2010 Study Recruiting NCT02894645 Phase 4 Prednisolone;Dexamethasone;L-Asparaginase;Vincristine;Methotrexate;Daunorubicin;Doxorubicin;Cyclophosphamide;Cytarabine;6-Mercaptopurine;Thioguanine;Fludarabine;Imatinib
10 Intranasal Ketamine for Anxiolysis in Pediatric Emergency Department Patients Recruiting NCT03043430 Phase 4 Ketamine 100 MG/ML;Midazolam 5 MG/ML
11 Identification of New Immune Factors Specific of Relapse in Childhood B Lineage Acute Lymphoblastic Leukemia Recruiting NCT02618109 Phase 4
12 Study Comparing Bivalirudin Versus Heparin in Neonatal and Pediatric ECMO Not yet recruiting NCT03318393 Phase 4 Bivalirudin;Unfractionated heparin
13 A Randomized Phase IV Control Trial of Single High Dose Oral Vitamin D3 in Pediatric Patients Undergoing HSCT Not yet recruiting NCT03176849 Phase 4
14 Allogeneic Stem Cell Transplantation in Children and Adolescents With Acute Lymphoblastic Leukaemia Unknown status NCT01423747 Phase 3 VP16;VP16, ATG;Fludarabine, OKT3, Treosulfan, Thiotepa;VP16, ATG
15 ALL-SCT BFM International- HSCT in Children and Adolescents With ALL Unknown status NCT01423500 Phase 3 VP16;VP16, ATG;Fludarabine, OKT3, Treosulfan, Thiotepa;VP16, ATG
16 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT00103285 Phase 3 doxorubicin hydrochloride;cytarabine;dexamethasone;pegaspargase;methotrexate;leucovorin calcium;mercaptopurine;cyclophosphamide;thioguanine;vincristine sulfate
17 Hormone Therapy Plus Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia Unknown status NCT00003437 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;pegaspargase;prednisolone;thioguanine;vincristine sulfate
18 Combination Chemotherapy in Treating Children With Relapsed Acute Lymphocytic Leukemia Unknown status NCT00002499 Phase 2, Phase 3 asparaginase;cytarabine;daunorubicin hydrochloride;dexamethasone;methotrexate;prednisone;vincristine sulfate
19 Risk-Adjusted Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia Unknown status NCT00764907 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate;vindesine
20 Combination Chemotherapy Plus Steroid Therapy in Treating Children With Acute Lymphoblastic Leukemia or Lymphoblastic Non-Hodgkin's Lymphoma Unknown status NCT00003728 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;leucovorin calcium;mercaptopurine;methotrexate;methylprednisolone;mitoxantrone hydrochloride;prednisolone;therapeutic hydrocortisone;thioguanine;vincristine sulfate;vindesine
21 Combination Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia Completed NCT00002816 Phase 3 cytarabine;dexamethasone;etoposide;idarubicin;ifosfamide;leucovorin calcium;mesna;pegaspargase;therapeutic hydrocortisone;thioguanine;vincristine sulfate;Methotrexate
22 ALL2008 Protocol for Childhood Acute Lymphoblastic Leukemia (ALL) - 6MP Consolidation Therapy Completed NCT00816049 Phase 3 6MPindividualized;6MPfixed
23 ALL2008 Protocol for Childhood Acute Lymphoblastic Leukemia Intermittent Versus Continuous PEG Asparaginase Completed NCT00819351 Phase 3 PEG Asparaginase at six weeks interval;PEG Asparaginase at two weeks interval
24 Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia Completed NCT00005585 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;leucovorin calcium;mercaptopurine;methotrexate;pegaspargase;thioguanine;vincristine sulfate
25 Zometa Study in Pediatric Acute Lymphoblastic Leukemia Completed NCT01656512 Phase 3 zolendronic acid;calcium & vitamin D
26 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Children With Acute Lymphoblastic Leukemia Completed NCT00022737 Phase 3 asparaginase;cyclophosphamide;cyclosporine;cytarabine;daunorubicin hydrochloride;dexamethasone;etoposide;ifosfamide;imatinib mesylate;leucovorin calcium;mercaptopurine tablet;methotrexate;pegaspargase;vincristine sulfate
27 Combination Chemotherapy Based on Risk of Relapse in Treating Young Patients With Acute Lymphoblastic Leukemia Completed NCT00613457 Phase 3 dexamethasone;asparaginase;Asparaginase;cyclophosphamide;cytarabine;daunorubicin;doxorubicin;Etoposide;Ifosfamide;mercaptopurine;Methotrexate;prednisone;thioguanine;Vincristine;Vindesine
28 A Severity-Adapted Clinical Trial of Diminished Bone Mineral Density in Acute Lymphoblastic Leukemia Survivors Completed NCT00186901 Phase 3 Calcium carbonate (Tums), vitamin D
29 Comparison of Different Combination Chemotherapy Regimens in Treating Children With Acute Lymphoblastic Leukemia Completed NCT00005945 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;pegaspargase;thioguanine;vincristine sulfate
30 Combination Chemotherapy in Treating Young Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia Completed NCT00967057 Phase 3 asparaginase;dexamethasone;idarubicin;methotrexate;mitoxantrone hydrochloride;pegaspargase;vincristine sulfate
31 Comparison of Different Combination Chemotherapy Regimens in Treating Infants With Acute Lymphoblastic Leukemia Completed NCT00015873 Phase 3 asparaginase;cytarabine;mercaptopurine;methotrexate;prednisolone;vincristine sulfate
32 Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia Completed NCT00005596 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;leucovorin calcium;mercaptopurine;methotrexate;pegaspargase;thioguanine;vincristine sulfate
33 Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia Completed NCT00005603 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate
34 Low-Dose or High-Dose Vincristine and Combination Chemotherapy in Treating Young Patients With Relapsed B-Cell Acute Lymphoblastic Leukemia Completed NCT00381680 Phase 3 vincristine sulfate;prednisone;doxorubicin hydrochloride;pegaspargase;cytarabine;methotrexate;dexamethasone;etoposide;cyclophosphamide;leucovorin calcium;asparaginase;mercaptopurine
35 Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia Completed NCT00002744 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;pegaspargase;prednisone;therapeutic hydrocortisone;thioguanine;vincristine sulfate
36 Combination Chemotherapy in Treating Children With Acute Lymphocytic Leukemia Completed NCT00002812 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;idarubicin;mercaptopurine;methotrexate;pegaspargase;prednisone;thioguanine;vincristine sulfate
37 Combination Chemotherapy Based on Risk of Relapse in Treating Young Patients With Acute Lymphoblastic Leukemia Completed NCT00430118 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate;vindesine
38 Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed NCT00720109 Phase 2, Phase 3 Asparaginase;Cyclophosphamide;Cytarabine;Dasatinib;Daunorubicin Hydrochloride;Dexamethasone;Etoposide;Hydrocortisone Sodium Succinate;Ifosfamide;Leucovorin Calcium;Mercaptopurine;Methotrexate;Methylprednisolone;Pegaspargase;Prednisone;Vincristine Sulfate
39 Dexamethasone Compared With Prednisone During Induction Therapy and MTX With or Without Leucovorin During Maintenance Therapy in Treating Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia Completed NCT00075725 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;pegaspargase;prednisone;thioguanine;vincristine sulfate
40 Combination Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia or Advanced Lymphoblastic Non-Hodgkin's Lymphoma Completed NCT01230983 Phase 3 asparaginase;cytarabine;dexrazoxane hydrochloride;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;prednisone;therapeutic hydrocortisone;vincristine sulfate
41 Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant Completed NCT01305200 Phase 3 supersaturated calcium phosphate rinse
42 Bone Marrow Transplantation in Treating Patients With Leukemia, Myelodysplasia, or Lymphoblastic Lymphoma Completed NCT00003187 Phase 2, Phase 3 cyclophosphamide;cyclosporine;cytarabine;methotrexate;methylprednisolone
43 Personalized Information or Basic Information in Helping Patients Make Decisions About Participating in a Clinical Trial Completed NCT00750009 Phase 3
44 Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation Completed NCT00045292 Phase 3 acyclovir;acyclovir sodium;valacyclovir
45 Bone Marrow Transplantation in Treating Patients With Acute Leukemia in First or Second Remission Completed NCT00002534 Phase 3 cyclophosphamide;cytarabine;methylprednisolone;thiotepa
46 Levofloxacin in Preventing Infection in Young Patients With Acute Leukemia Receiving Chemotherapy or Undergoing Stem Cell Transplantation Completed NCT01371656 Phase 3 levofloxacin
47 Treatment of Bone Marrow to Prevent Graft-Versus-Host Disease in Patients With Acute or Chronic Leukemia Undergoing Bone Marrow Transplantation Completed NCT00004255 Phase 2, Phase 3 cyclophosphamide;fludarabine phosphate;methylprednisolone;tacrolimus
48 TITLE:Less Intensive Therapy for Children With Non-Hodgkin's Lymphoma Completed NCT00002757 Phase 3 cyclophosphamide;cytarabine;doxorubicin hydrochloride;etoposide;methotrexate;prednisolone;prednisone;therapeutic hydrocortisone;vincristine sulfate
49 Ondansetron in Treating Patients With Advanced Cancer and Chronic Nausea and Vomiting Not Caused by Cancer Treatment Completed NCT00006348 Phase 3 ondansetron
50 A Web-Based Stem Cell Transplant Support System or Standard Care in Young Patients Undergoing Stem Cell Transplant and Their Families Completed NCT00782145 Phase 3

Search NIH Clinical Center for Acute Lymphoblastic Leukemia, Childhood

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Stem-cell-based therapeutic approaches for Acute Lymphoblastic Leukemia, Childhood:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Acute Lymphoblastic Leukemia, Childhood:
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Acute Lymphoblastic Leukemia, Childhood

Anatomical Context for Acute Lymphoblastic Leukemia, Childhood

MalaCards organs/tissues related to Acute Lymphoblastic Leukemia, Childhood:

41
Bone, Bone Marrow, T Cells, Myeloid, B Cells, Kidney, Testes

Publications for Acute Lymphoblastic Leukemia, Childhood

Articles related to Acute Lymphoblastic Leukemia, Childhood:

(show all 50)
# Title Authors Year
1
Air toxics and early childhood acute lymphocytic leukemia in Texas, a population based case control study. ( 27301866 )
2016
2
Comparative study of quality of life of adult survivors of childhood acute lymphocytic leukemia and Wilms' tumor. ( 26537509 )
2015
3
Cranial radiotherapy predisposes to abdominal adiposity in survivors of childhood acute lymphocytic leukemia. ( 23433104 )
2013
4
Pyrethroid pesticide exposure and risk of childhood acute lymphocytic leukemia in Shanghai. ( 23153377 )
2012
5
[Relationship between genetic polymorphism of multidrug resistance 1 gene and the risk of childhood acute lymphocytic leukemia]. ( 23158821 )
2012
6
Exposure to magnetic fields and childhood acute lymphocytic leukemia in SALo Paulo, Brazil. ( 21840286 )
2011
7
Monitoring treatment response of childhood acute lymphocytic leukemia with certain molecular and biochemical markers. ( 21182165 )
2010
8
High incidence of Epstein-Barr virus infection in childhood acute lymphocytic leukemia. ( 21045472 )
2010
9
Isolated extramedullary relapse in childhood acute lymphocytic leukemia. ( 20717757 )
2010
10
High incidence of Epstein Barr virus infection in childhood acute lymphocytic leukemia: a preliminary study. ( 20090225 )
2010
11
Working memory in survivors of childhood acute lymphocytic leukemia: functional neuroimaging analyses. ( 19953649 )
2010
12
Executive function, coping, and behavior in survivors of childhood acute lymphocytic leukemia. ( 18667478 )
2009
13
Transient hyperglycemia during childhood acute lymphocytic leukemia chemotherapy: an old event revisited. ( 19701154 )
2009
14
Intractable epilepsy in patients treated for childhood acute lymphocytic leukemia. ( 19041267 )
2009
15
Shortage of chemotherapeutic agents in Iraq and outcome of childhood acute lymphocytic leukemia, 1990-2002. ( 18650525 )
2008
16
Hyperglycemia during induction therapy is associated with increased infectious complications in childhood acute lymphocytic leukemia. ( 18523991 )
2008
17
[Expression of WAVE1 in childhood acute lymphocytic leukemia and in the apoptosis of Jurkat cells induced by adriamycin]. ( 18947485 )
2008
18
[Detection of human cyclin C gene expression in childhood acute lymphocytic leukemia using real-time fluorescence quantitative PCR]. ( 18289462 )
2008
19
Socioeconomic status and childhood acute lymphocytic leukemia incidence in SALo Paulo, Brazil. ( 18688860 )
2008
20
Clinical role of bone marrow angiogenesis in childhood acute lymphocytic leukemia. ( 17461513 )
2007
21
A meta-analysis of the neurocognitive sequelae of treatment for childhood acute lymphocytic leukemia. ( 16628558 )
2007
22
Polymorphisms in the MTHFR gene and their possible association with susceptibility to childhood acute lymphocytic leukemia in an Indian population. ( 16923565 )
2006
23
Childhood acute lymphocytic leukemia and perspectives on risk assessment of early-life stage exposures. ( 17049456 )
2006
24
Expression of the glucocorticoid receptor and its isoforms in relation to glucocorticoid resistance in childhood acute lymphocytic leukemia. ( 16154856 )
2005
25
Secondary malignant neoplasms of the bladder after cyclophosphamide treatment for childhood acute lymphocytic leukemia. ( 14752871 )
2004
26
Conversion of childhood acute lymphocytic leukemia (L2) with a double t(12;21) to juvenile myelomonocytic leukemia with a novel t(4;11)(p12;q23): a cytogenetic, morphologic, and immunophenotypic study. ( 14623459 )
2003
27
Birth characteristics, maternal reproductive history, hormone use during pregnancy, and risk of childhood acute lymphocytic leukemia by immunophenotype (United States). ( 11899114 )
2002
28
Raised blast glutathione levels are associated with an increased risk of relapse in childhood acute lymphocytic leukemia. ( 11154214 )
2001
29
Increased BAX expression is associated with an increased risk of relapse in childhood acute lymphocytic leukemia. ( 10194447 )
1999
30
Salvage therapy for relapsed or refractory childhood acute lymphocytic leukemia by alternative administration a lymphoid- and myeloid-directed chemotherapeutic regimen consisting of dual modulation of ara-C, hydroxyurea, and etoposide. ( 9393595 )
1997
31
ETV6 is the target of chromosome 12p deletions in t(12;21) childhood acute lymphocytic leukemia. ( 9305598 )
1997
32
On the prognostic value of systemic methotrexate clearance in childhood acute lymphocytic leukemia. ( 9225071 )
1997
33
Malignant external otitis as the presentation of childhood acute lymphocytic leukemia. ( 8970229 )
1996
34
Hepatotoxicity of 6-mercaptopurine in childhood acute lymphocytic leukemia: pharmacokinetic characteristics. ( 8531858 )
1996
35
Prognostic importance of p15INK4B and p16INK4 gene inactivation in childhood acute lymphocytic leukemia. ( 8622065 )
1996
36
Epidemiological characteristics of childhood acute lymphocytic leukemia. ( 7934179 )
1994
37
Changes in lactate dehydrogenase isoenzymes associated with relapse of childhood acute lymphocytic leukemia. ( 7826848 )
1994
38
Epidemiological characteristics of childhood acute lymphocytic leukemia. Analysis by immunophenotype. The Childrens Cancer Group. ( 8182942 )
1994
39
Adult and childhood acute lymphocytic leukemia: are they different diseases? ( 8416287 )
1993
40
Childhood acute lymphocytic leukemia with a preleukemic phase: report of an associated translocation and review of the literature. ( 8260901 )
1993
41
Clinical trials of teniposide (VM-26) in childhood acute lymphocytic leukemia. ( 1411639 )
1992
42
Neonatal exposure to protoporphyrin-activating lighting as a contributing cause of childhood acute lymphocytic leukemia. ( 1617127 )
1992
43
Abnormal cerebral glucose metabolism in long-term survivors of childhood acute lymphocytic leukemia. ( 2042943 )
1991
44
Decrease in cerebral metabolic rate of glucose after high-dose methotrexate in childhood acute lymphocytic leukemia. ( 2242171 )
1990
45
N-ras gene point mutations in childhood acute lymphocytic leukemia correlate with a poor prognosis. ( 2407301 )
1990
46
Improved prognosis for childhood acute lymphocytic leukemia with very high white blood cell count (greater than 100/nl) with rotation of non-cross-resistant drug combinations. ( 2182442 )
1990
47
Effective prevention of central nervous system leukemia with intrathecal methotrexate and intrathecal methotrexate, cytosine arabinoside, and hydrocortisone in childhood acute lymphocytic leukemia. ( 2323651 )
1990
48
An unusual t(9;12)(p13;q24) in childhood acute lymphocytic leukemia. ( 2702632 )
1989
49
Induction of tumoricidal activity and alterations of growth by interleukin-2 and manipulation of protein kinase C and cytosolic calcium in childhood acute lymphocytic leukemia cells. ( 2787455 )
1989
50
Brain sarcoma of meningeal origin after cranial irradiation in childhood acute lymphocytic leukemia. Case report. ( 6590801 )
1984

Variations for Acute Lymphoblastic Leukemia, Childhood

Copy number variations for Acute Lymphoblastic Leukemia, Childhood from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 250737 9 21967751 21994490 Deletion CDKN2A pediatric acute lymphoblastic leukemia

Expression for Acute Lymphoblastic Leukemia, Childhood

Search GEO for disease gene expression data for Acute Lymphoblastic Leukemia, Childhood.

Pathways for Acute Lymphoblastic Leukemia, Childhood

GO Terms for Acute Lymphoblastic Leukemia, Childhood

Biological processes related to Acute Lymphoblastic Leukemia, Childhood according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of phosphorylation GO:0042326 9.46 CDKN2A CDKN2B
2 replicative senescence GO:0090399 9.43 CDKN2A MME
3 hematopoietic stem cell proliferation GO:0071425 9.4 ETV6 RUNX1
4 tetrahydrofolate metabolic process GO:0046653 9.37 MTHFR TYMS
5 response to folic acid GO:0051593 9.32 MTHFR TYMS
6 negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031658 9.26 CDKN2A CDKN2B
7 methionine metabolic process GO:0006555 9.16 MTHFD1 MTHFR
8 folic acid metabolic process GO:0046655 9.13 MTHFD1 MTHFR SLC19A1
9 tetrahydrofolate interconversion GO:0035999 8.8 MTHFD1 MTHFR TYMS

Molecular functions related to Acute Lymphoblastic Leukemia, Childhood according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cofactor binding GO:0048037 9.16 ASNS TYMS
2 folic acid binding GO:0005542 8.96 SLC19A1 TYMS
3 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 8.62 CDKN2A CDKN2B

Sources for Acute Lymphoblastic Leukemia, Childhood

3 CDC
7 CNVD
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10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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