MCID: ACT074
MIFTS: 63

Acute Lymphocytic Leukemia

Categories: Blood diseases, Bone diseases, Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Acute Lymphocytic Leukemia

MalaCards integrated aliases for Acute Lymphocytic Leukemia:

Name: Acute Lymphocytic Leukemia 39 12 77 44 15 74
Acute Lymphoblastic Leukemia 12 15
Precursor Cell Lymphoblastic Leukemia Lymphoma 74

Classifications:



External Ids:

Disease Ontology 12 DOID:9952
ICD9CM 36 204.0
NCIt 51 C3167
SNOMED-CT 69 90151006 91857003
ICD10 34 C91.0 C91.00

Summaries for Acute Lymphocytic Leukemia

MedlinePlus : 44 Leukemia is cancer of the white blood cells. White blood cells help your body fight infection. Your blood cells form in your bone marrow. In leukemia, however, the bone marrow produces abnormal white blood cells. These cells crowd out the healthy blood cells, making it hard for blood to do its work. In acute lymphocytic leukemia (ALL), also called acute lymphoblastic leukemia, there are too many of specific types of white blood cells called lymphocytes or lymphoblasts. ALL is the most common type of cancer in children. Possible risk factors for ALL include being male, being white, previous chemotherapy treatment, exposure to radiation, and for adults, being older than 70. Symptoms of ALL include: Weakness or feeling tired Fever Easy bruising or bleeding Bleeding under the skin Shortness of breath Weight loss or loss of appetite Pain in the bones or stomach Pain or a feeling of fullness below the ribs Painless lumps in the neck, underarm, stomach, or groin Tests that examine the blood and bone marrow diagnose ALL. Treatments include chemotherapy, radiation therapy, stem cell transplants, and targeted therapy. Targeted therapy uses substances that attack cancer cells without harming normal cells. Once the leukemia is in remission, you need additional treatment to make sure that it does not come back. NIH: National Cancer Institute

MalaCards based summary : Acute Lymphocytic Leukemia, also known as acute lymphoblastic leukemia, is related to adult acute lymphocytic leukemia and acute t cell leukemia, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Acute Lymphocytic Leukemia is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are Pathways in cancer and Oncogene Induced Senescence. The drugs Mercaptopurine and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone, and related phenotypes are homeostasis/metabolism and growth/size/body region

Disease Ontology : 12 A lymphoblastic leukemia that is characterized by over production of lymphoblasts.

Wikipedia : 77 Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the... more...

Related Diseases for Acute Lymphocytic Leukemia

Diseases in the Lymphocytic Leukemia family:

Leukemia, Chronic Lymphocytic 2 Leukemia, Chronic Lymphocytic
Leukemia, Chronic Lymphocytic 1 Leukemia, Chronic Lymphocytic 3
Leukemia, Chronic Lymphocytic 4 Leukemia, Chronic Lymphocytic 5
Acute Lymphocytic Leukemia Adult Acute Lymphocytic Leukemia

Diseases related to Acute Lymphocytic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 740)
# Related Disease Score Top Affiliating Genes
1 adult acute lymphocytic leukemia 34.5 CDKN2B MTHFR TYMS
2 acute t cell leukemia 34.0 NOTCH1 TAL1 TAL2
3 leukemia, acute lymphoblastic 33.3 BCR ETV6 MME PAX5 TPMT
4 acute leukemia 32.8 ETV6 MTHFR PAX5 TAL1
5 acute lymphoblastic leukemia, childhood 32.8 ASNS CDKN2A CDKN2B ETV6 MME MTHFR
6 leukemia 32.6 BCR CDKN2B-AS1 ETV6 NOTCH1 TAL1 TAL2
7 precursor t-cell acute lymphoblastic leukemia 32.2 ASNS BCR CDKN2A CDKN2B ETV6 NOTCH1
8 leukemia, acute lymphoblastic 3 32.2 BCR CDKN2A CDKN2B ETV6 MME PAX5
9 lymphocytic leukemia 31.9 BCR ETV6 MME NOTCH1 PAX5 TAL1
10 lymphoblastic lymphoma 30.6 CDKN2B MME NOTCH1 TAL1
11 childhood leukemia 30.5 ETV6 MTHFR TP53
12 grade iii astrocytoma 30.5 CDKN2A CDKN2B TP53
13 oligodendroglioma 30.4 CDKN2A CDKN2B TP53
14 leukemia, chronic lymphocytic 30.4 BCR NOTCH1 PAX5 TP53
15 cll/sll 30.3 MME PAX5 TP53
16 spitz nevus 30.3 CDKN2A TP53
17 mantle cell lymphoma 30.1 CDKN2A MME PAX5 TP53
18 b-cell lymphomas 30.1 CDKN2A MME PAX5 TP53
19 t-cell leukemia 30.1 CDKN2A NOTCH1 TAL1 TP53
20 lymphoma, non-hodgkin, familial 30.0 BCR CDKN2B MME NOTCH1 PAX5 TP53
21 leukemia, acute myeloid 29.9 BCR CDKN2B CDKN2B-AS1 ETV6 MME TP53
22 osteogenic sarcoma 29.3 CDKN2B-AS1 TP53 XIST
23 nasopharyngeal carcinoma 29.3 CDKN2A CDKN2B-AS1 TP53 XIST
24 b-cell childhood acute lymphoblastic leukemia 12.8
25 b-cell adult acute lymphocytic leukemia 12.3
26 t-cell adult acute lymphocytic leukemia 12.3
27 acute lymphoblastic leukemia congenital sporadic aniridia 12.3
28 t-cell childhood acute lymphocytic leukemia 12.3
29 null-cell leukemia 11.8
30 lymphoblastic leukemia, acute, with lymphomatous features 11.7
31 medulloblastoma 11.7
32 ataxia-telangiectasia 11.6
33 prostate cancer 10.6
34 carney complex, type 1 10.6
35 caronte 10.6
36 methotrexate toxicity or dose selection 10.5 MTHFR SLC19A1
37 fallopian tube endometrioid adenocarcinoma 10.5 CDKN2A MME
38 hemifacial spasm 10.5 MTHFR TYMS
39 splenic diffuse red pulp small b-cell lymphoma 10.4 NOTCH1 TP53
40 xp22.3 microdeletion syndrome 10.4
41 tenosynovial giant cell tumor 10.4 CDKN2A CDKN2B
42 malignant leydig cell tumor 10.4 MME PAX5
43 invasive bladder transitional cell carcinoma 10.4 NOTCH1 TP53
44 pancytopenia 10.4
45 bone squamous cell carcinoma 10.4 CDKN2A NOTCH1
46 bladder squamous cell carcinoma 10.4 CDKN2A TP53
47 keratinizing squamous cell carcinoma 10.4 CDKN2A TP53
48 hepatitis 10.4
49 allergic hypersensitivity disease 10.4
50 lymphoma 10.4

Graphical network of the top 20 diseases related to Acute Lymphocytic Leukemia:



Diseases related to Acute Lymphocytic Leukemia

Symptoms & Phenotypes for Acute Lymphocytic Leukemia

UMLS symptoms related to Acute Lymphocytic Leukemia:


angina pectoris, edema, chest pain

MGI Mouse Phenotypes related to Acute Lymphocytic Leukemia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.25 ANKS1B BCR CDKN2A CDKN2B ETV6 MME
2 growth/size/body region MP:0005378 10.23 ASNS BCR CDKN2A ETV6 MTHFR NOTCH1
3 hematopoietic system MP:0005397 10.21 ASNS BCR CDKN2A CDKN2B ETV6 NOTCH1
4 immune system MP:0005387 10.07 BCR CDKN2A CDKN2B ETV6 MME NOTCH1
5 integument MP:0010771 9.97 CDKN2A CDKN2B ETV6 MME MTHFR NOTCH1
6 mortality/aging MP:0010768 9.97 ANKS1B BCR CDKN2A CDKN2B ETV6 MTHFR
7 liver/biliary system MP:0005370 9.8 BCR CDKN2A MME MTHFR NOTCH1 SLC19A1
8 neoplasm MP:0002006 9.43 CDKN2A CDKN2B ETV6 NOTCH1 PAX5 TP53
9 nervous system MP:0003631 9.36 ANKS1B ASNS BCR CDKN2A MTHFR NOTCH1

Drugs & Therapeutics for Acute Lymphocytic Leukemia

Drugs for Acute Lymphocytic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 656)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mercaptopurine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-44-2 667490
2
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 302-25-0
3
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
4
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 2068-78-2, 57-22-7 5978
5
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1959-05-2, 59-05-2 126941
6
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 135968-09-1
7
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
8
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2921-57-5
9
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-18-0, 6055-19-2 2907
10
Cytarabine Approved, Experimental, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 147-94-4, 65-46-3 6253
11
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 174722-31-7 10201696
12
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1177-87-3
13
Sargramostim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 123774-72-1, 83869-56-1
14
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-02-2 5743
15
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58957-92-9 42890
16
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-05-9 143 6006
17
Dasatinib Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 302962-49-8 3062316
18
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53-03-2 5865
19
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 20830-81-3 30323
20
Pegaspargase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 130167-69-0
21
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 23214-92-8 31703
22
Cladribine Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 4291-63-8 20279
23
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 33419-42-0 36462
24
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 75607-67-9, 21679-14-1 30751
25
Vindesine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 53643-48-4, 59917-39-4 40839
26
Thioguanine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 154-42-7 2723601
27
Teniposide Approved Phase 4,Phase 3,Phase 2,Not Applicable 29767-20-2 34698
28
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 3778-73-2 3690
29
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 65271-80-9 4212
30
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-23-7 5754
31
Hydrocortisone acetate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-03-3
32
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 22916-47-8 4189
33
Thiotepa Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 52-24-4 5453
34
Busulfan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 55-98-1 2478
35
Epirubicin Approved Phase 4,Phase 3,Phase 2 56420-45-2 41867
36
Posaconazole Approved, Investigational, Vet_approved Phase 4,Not Applicable 171228-49-2 147912
37
Micafungin Approved, Investigational Phase 4,Phase 2 235114-32-6 477468 3081921
38
Methylphenidate Approved, Investigational Phase 4,Not Applicable 113-45-1 4158
39
Dopamine Approved Phase 4,Not Applicable 62-31-7, 51-61-6 681
40
Oprelvekin Approved, Investigational Phase 4 145941-26-0
41
inotuzumab ozogamicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 635715-01-4
42
Azacitidine Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 320-67-2 9444
43
Decitabine Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 2353-33-5 451668
44
Morphine Approved, Investigational Phase 4,Phase 3,Not Applicable 57-27-2 5288826
45
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 1994-09-7, 94-09-7 2337
46
tannic acid Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 1401-55-4
47
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2 1397-89-3 5280965 14956
48
Nicotine Approved Phase 4 54-11-5 89594 942
49
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 59-30-3 6037
50
Tyrosine Approved, Investigational, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1 60-18-4 6057

Interventional clinical trials:

(show top 50) (show all 1887)
# Name Status NCT ID Phase Drugs
1 German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT00198978 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Cytarabine;Idarubicin;Granulocyte-Colony-Stimulating Factor;Mercaptopurine;Methotrexate;Rituximab;HDARAC;Vincristine;Depocyte;Asparaginase
2 Low-dose Chemotherapy Combine With Tyrosine Kinase Inhibitor to Treat ph+ Acute Lymphoblastic Leukemia Patients Unknown status NCT02690922 Phase 4 Dasatinib;prednisone;dexamethasone;methotrexate
3 Treatment Protocol of Children With Philadelphia Chromosome Negative High Risk Acute Lymphoblastic Leukemia Unknown status NCT01990807 Phase 4 Idarubicin(IDA)
4 The GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia Unknown status NCT00846703 Phase 4 6-mercaptopurine, Methotrexate;6-mercaptopurine, Methotrexate, Vincristine, Dexamethasone
5 Medical Research Council (MRC) Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003 Unknown status NCT00222612 Phase 4 Standard childhood UK ALL protocol;Intensified treatment including Capizzi maintenance
6 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (07/2003) Unknown status NCT00198991 Phase 4 Cyclophosphamide;Dexamethasone;Vincristine;daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Prednisolone;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Cladribine
7 Malaysia-Singapore Acute Lymphoblastic Leukemia 2010 Study Unknown status NCT02894645 Phase 4 Prednisolone;Dexamethasone;L-Asparaginase;Vincristine;Methotrexate;Daunorubicin;Doxorubicin;Cyclophosphamide;Cytarabine;6-Mercaptopurine;Thioguanine;Fludarabine;Imatinib
8 Poly(Ethylene Glycol)(PEG)-Asparaginase During Two Treatment Courses Unknown status NCT00192673 Phase 4 PEG-asparaginase
9 HD-Idarubicin/Etoposide Intensified Conditioning Regimen Allo-HSCT for Adult ALL Unknown status NCT01873807 Phase 4 IDA;CTX;VP-16
10 Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults Unknown status NCT00797810 Phase 4 Rituximab
11 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4 Growth Hormone
12 Pulses of Vincristine and Dexamethasone in BFM Protocols for Children With Acute Lymphoblastic Leukemia Completed NCT00411541 Phase 4 vincristine;dexamethasone
13 Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia Completed NCT00199095 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone;Idarubicin;Ifosfamide;Methotrexate;Mercaptopurine;VM26;Vincristine
14 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (06/99) Completed NCT00199056 Phase 4 Dexamethasone / Prednisolone;Cyclophosphamide;Methotrexate;Vincristine / Vindesine;Daunorubicin;Asparaginase;G-CSF;Cytarabine;6-Mercaptopurine;VP16;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Ifosfamide
15 Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia Completed NCT01358253 Phase 4 Cyclophosphamide;Doxorubicin;Vincristine;Dexamethasone;Cytarabine;Methotrexate;Rituximab;6-Mercaptopurine;Prednisone;L-asparaginase
16 LAL-AR-N-2005:Study Treatment for Children High Risk Acute Lymphoblastic Leukemia Completed NCT00526409 Phase 4 Prednisolone;Daunorubicin;Vincristine;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside
17 PETHEMA LAL-RI/96: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Completed NCT00494897 Phase 4 Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin;Mercaptopurine;Prednisone;Vincristine;Methotrexate
18 LAL-Ph-2000: Treatment of Acute Lymphoblastic Leukemia Chromosome Philadelphia Positive Completed NCT00526305 Phase 4 Vincristine;Daunorubicin;Prednisone;L-Asparaginase;Mitoxantrone;Cytosine Arabinoside;Hydrocortisone;Mercaptopurine;Cyclophosphamide;Dexamethasone
19 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93) Completed NCT00199069 Phase 4 Asparaginase;Vincristine;Daunorubicin, Adriamycin;Cyclophosphamide;Ifosfamide;Cytarabine;Mitoxantrone;Methotrexate;6-Mercaptopurine;6-Thioguanine;VM26;Dexamethasone / Prednisolone
20 Trial for Treatment of Adult Patients With Standard Risk Acute Lymphoblastic Leukemia With Chemotherapy and Rituximab Completed NCT00199004 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Vincristine;Daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Adriamycin;Thioguanine;VM26;Rituximab
21 Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome Completed NCT01200355 Phase 4 micafungin;posaconazole
22 ALL-REZ BFM 2002: Multi-Center Study for Children With Relapsed Acute Lymphoblastic Leukemia Completed NCT00114348 Phase 4
23 Learning Impairments Among Survivors of Childhood Cancer Completed NCT00576472 Phase 4 Methylphenidate
24 Effect of rhIL-11 in Patients With Thrombocytopenia for Childhood ALL Completed NCT02314273 Phase 4 rhIL-11
25 LAL-BR/2001: Study Treatment to Low Risk ALL Completed NCT00526175 Phase 4 Prednisone;Vincristine;Daunorubicin;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside;Mercaptopurine;VP-16
26 The Study on the Pharmacokinetics of PEG-rhG-CSF in Children and Adolescents Completed NCT02953730 Phase 4 PEG-rhG-CSF
27 Trial for the Treatment of Newly Diagnosed Mature B-Cell Acute Lymphoblastic Leukemia (B-ALL), Burkitt's Non-Hodgkin's Lymphoma (NHL) and Other High-grade Lymphoma in Adults Completed NCT00199082 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone/Prednisolone;VP16;Ifosfamide;Methotrexate;G-CSF;Rituximab;Vincristine/Vindesine
28 German Multicenter Trial for the Treatment of Newly Diagnosed T-lymphoblastic Lymphoma in Adults Completed NCT00199017 Phase 4 Dexamethasone/Prednisolone;Cyclophosphamide;Vincristine;Daunorubicin;Asparaginase;G-CSF;Mercaptopurine;Cytarabine;Methotrexate;VP16;Vindesine;Adriamycin;Thioguanine;HDARAC;Cladribine
29 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4 cyclophosphamide;thiotepa
30 Nilotinib in Newly Diagnosed Adult Philadelphia Chromosome & /or BCR-ABL Positive Chronic Myeloid Leukaemia in Chronic Phase Completed NCT01061177 Phase 4 Nilotinib
31 Identification of New Immune Factors Specific of Relapse in Childhood B Lineage Acute Lymphoblastic Leukemia Recruiting NCT02618109 Phase 4
32 Protocol For the Treatment Acute Lymphoblastic Leukemia With Ph 'Negative in Elderly Patients (> 55 Years) Recruiting NCT01366898 Phase 4 Dexamethasona, Idarubicine, ARA-C, Methotrexate
33 A Study Of Two Inotuzumab Ozogamicin Doses in Relapsed/ Refractory Acute Lymphoblastic Leukemia Transplant Eligible Patients Recruiting NCT03677596 Phase 4 inotuzumab ozogamicin-dose level 2;Inotuzumab ozogamicin-dose level 1
34 Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVE Recruiting NCT01491763 Phase 4 Imatinib
35 Study on Two Different Formulations of 6-mercaptopurine. Tablet Versus Oral Liquid Recruiting NCT01906671 Phase 4 Xaluprine;Puri-Nethol
36 PETHEMA LAL-07FRAIL: All Treatment In Fragile Patients Ph' Negative Over 55 Years Recruiting NCT01358201 Phase 4 vINCRISTINE;Dexamethasone;Methotrexate;Cytosine arabinoside
37 ALL SCTped FORUM - Pharmacogenomic Study (add-on Study) Recruiting NCT02670564 Phase 4
38 Pethema LAL-RI/2008: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Recruiting NCT02036489 Phase 4 Vincristine;Daunorubicin;Prednisone;L-asparaginase;Ciclophosphamide;Metotrexate;ARA-C;Hidrocortisone;Mercaptopurine;VP-16;Dexametasone
39 ATG Based Conditioning Regimen in HLA Related HSCT for Aggressive T-cell Tumors Recruiting NCT02938741 Phase 4 Anti-human Thymoglobulin;Placebo
40 G-CSF Alone or Combination With GM-CSF on Prevention and Treatment of Infection in Children With Malignant Tumor Recruiting NCT02933333 Phase 4
41 A Clinical Trial of Decitabine in Relapsed or Refractory T-lymphoblastic Lymphoma Recruiting NCT03558412 Phase 4 Decitabine
42 Treatment of High Risk Adult Acute Lymphoblastic Leukemia Active, not recruiting NCT00853008 Phase 4 Vincristine;Daunorubicin;Prednisone;Mitoxantrone;Cytosine Arabinoside;Dexamethasone;Methotrexate (MTX);Cytarabine;ASP;Mercaptopurine;Teniposide;Hydrocortisone
43 Vaccinating Children After Chemotherapy Active, not recruiting NCT02447718 Phase 4
44 Determinants of Mercaptopurine Toxicity in Paediatric Acute Lymphoblastic Leukemia Maintenance Therapy Enrolling by invitation NCT03920813 Phase 4 Mercaptopurine
45 A Randomized Phase IV Control Trial of Single High Dose Oral Vitamin D3 in Pediatric Patients Undergoing HSCT Enrolling by invitation NCT03176849 Phase 4
46 ProphyALL - Study on the Safety of Liposomal Amphotericin B to Prevent Antifungal Infections in Elderly Patients With Acute Lymphoblastic Leukemia Terminated NCT00386997 Phase 4 liposomal amphotericin B (AmBisome®)
47 Atomoxetine for Children With Acquired Attentional Disorders Following Completion of Chemotherapy for ALL Terminated NCT00299234 Phase 4 Atomoxetine
48 Haplo-identical HSCT Versus Chemotherapy for Adult Acute Lymphoblastic Leukemia Patients Unknown status NCT02042690 Phase 3 Chemotherapy
49 Phase III Study of Vincristine Sulfate Liposome For Injection In Adults With Naïve Acute Lymphoblastic Leukemia Unknown status NCT02072785 Phase 3 Vincristine Sulfate Liposome;Vincristine Sulfate
50 Treatment of Acute Lymphoblastic Leukemia or Aggressive Lymphoma With Relapse in Central Nervous System With Depocyt Unknown status NCT00199108 Phase 2, Phase 3 Depocyt;Dexamethasone

Search NIH Clinical Center for Acute Lymphocytic Leukemia

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Genetic Tests for Acute Lymphocytic Leukemia

Anatomical Context for Acute Lymphocytic Leukemia

MalaCards organs/tissues related to Acute Lymphocytic Leukemia:

42
T Cells, B Cells, Bone, Bone Marrow, Myeloid, Testes, Skin

Publications for Acute Lymphocytic Leukemia

Articles related to Acute Lymphocytic Leukemia:

(show top 50) (show all 4138)
# Title Authors Year
1
An activating mutation of the NSD2 histone methyltransferase drives oncogenic reprogramming in acute lymphocytic leukemia. ( 30171259 )
2019
2
A successful multidisciplinary approach for treatment and for preserving the reproductive potential in a rare case of acute lymphocytic leukemia during pregnancy. ( 30179055 )
2019
3
Esophageal Varices in Adolescent and Young Adult Males with Acute Lymphocytic Leukemia. ( 30335538 )
2019
4
Novel EZH2 mutation in a patient with secondary B-cell acute lymphocytic leukemia after deletion 5q myelodysplastic syndrome treated with lenalidomide: A case report. ( 30608448 )
2019
5
FUSE binding protein 1 (FUBP1) expression is upregulated by T-cell acute lymphocytic leukemia protein 1 (TAL1) and required for efficient erythroid differentiation. ( 30653565 )
2019
6
PIM inhibitor SMI-4a induces cell apoptosis in B-cell acute lymphocytic leukemia cells via the HO-1-mediated JAK2/STAT3 pathway. ( 30658101 )
2019
7
Intractable anal pain in B-cell acute lymphocytic leukemia patients: treatment options. ( 30671206 )
2019
8
CD4+ cells as a potential biomarker for cytomegalovirus retinitis in children with acute lymphocytic leukemia. ( 30681505 )
2019
9
Allogeneic blood transfusion in 163 children with acute lymphocytic leukemia (a STROBE-compliant article). ( 30762790 )
2019
10
Poor Penetration of Existing Effective Chemoimmunotherapy for the Treatment of Older Patients With Newly Diagnosed Acute Lymphocytic Leukemia (ALL) or Refractory/Relapsed ALL. ( 30763202 )
2019
11
Bacterial translocation in acute lymphocytic leukemia. ( 30934014 )
2019
12
Catheter-related bloodstream infection by Microbacterium paraoxydans in a pediatric patient with B-cell precursor acute lymphocytic leukemia: A case report and review of literature on Microbacterium bacteremia. ( 30982728 )
2019
13
Insulin-dependent diabetes: A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia. ( 30216644 )
2019
14
Isavuconazole Treatment of Cerebral and Pulmonary Aspergillosis in a Pediatric Patient With Acute Lymphoblastic Leukemia: Case Report and Review of Literature. ( 31094909 )
2019
15
A novel germline SAMD9L mutation in a family with ataxia-pancytopenia syndrome and pediatric acute lymphoblastic leukemia. ( 30923096 )
2019
16
Bladder Artery Embolization for Massive Hematuria Treatment in a Patient With Ataxia-Telangiectasia Acute Lymphoblastic Leukemia. ( 30933018 )
2019
17
Bilateral trifocal IOL implantation in a pediatric case of cataract following steroid-therapy for acute lymphoblastic leukemia. ( 30555958 )
2019
18
Congenital B-cell Acute Lymphoblastic Leukemia with Congenital Rubella Infection. ( 30806367 )
2019
19
Monitoring of cytomegalovirus infection in non-transplant pediatric acute lymphoblastic leukemia patients during chemotherapy. ( 30681620 )
2019
20
Cytomegalovirus Retinitis during Maintenance Therapy in child with Acute Lymphoblastic Leukemia. ( 31086168 )
2019
21
CD20-negative primary middle ear diffuse large B-cell lymphoma coexpressing MYC and BCL-2 secondary to acute lymphoblastic leukemia: A case report. ( 30985716 )
2019
22
Dasatinib and low-intensity chemotherapy for Philadelphia chromosome-positive acute lymphoblastic leukemia in a child with Down syndrome. ( 30663211 )
2019
23
Feasibility and Potential Benefits of an Exercise Intervention in a Male With Down Syndrome Undergoing High-Dose Chemotherapy for Acute Lymphoblastic Leukemia: A Case Report. ( 30795696 )
2019
24
Development of acute lymphoblastic leukemia following treatment for acute myeloid leukemia in children with Down syndrome: A case report and retrospective review of Children's Oncology Group acute myeloid leukemia trials. ( 30908863 )
2019
25
Use of inotuzumab-ozogamicin in a child with Down syndrome and refractory B-cell precursor acute lymphoblastic leukemia. ( 30485640 )
2019
26
Posterior reversible encephalopathy syndrome in children with acute lymphoblastic leukemia: Experience of a single center using BFM protocols. ( 30868749 )
2019
27
Invasive fusariosis masquerading as extramedullary disease in rapidly progressive acute lymphoblastic leukemia. ( 30900813 )
2019
28
Growth hormone deficiency and neurocognitive function in adult survivors of childhood acute lymphoblastic leukemia. ( 30690723 )
2019
29
Gene mutations and pretransplant minimal residual disease predict risk of relapse in adult patients after allogeneic hematopoietic stem-cell transplantation for T cell acute lymphoblastic leukemia. ( 30950667 )
2019
30
Strong expression of p53 protein in bone marrow samples after hematopoietic stem cell transplantation indicates risk of relapse in pediatric acute lymphoblastic leukemia patients. ( 30955249 )
2019
31
Blinatumomab for Acute Lymphoblastic Leukemia Relapse After Allogeneic Hematopoietic Stem Cell Transplantation. ( 31002989 )
2019
32
Combination chemotherapy plus dasatinib leads to comparable overall survival and relapse-free survival rates as allogeneic hematopoietic stem cell transplantation in Philadelphia positive acute lymphoblastic leukemia. ( 31016870 )
2019
33
Allogeneic hematopoietic stem cell transplantation from unrelated donors is associated with higher infection rates in children with acute lymphoblastic leukemia - A prospective international multicenter trial on behalf of the BFM-SG and the EBMT-PDWP. ( 31095771 )
2019
34
Hematopoietic Stem Cell Transplantation Does Not Improve the Poor Outcome of Children With Hypodiploid Acute Lymphoblastic Leukemia: A Report From Children's Oncology Group. ( 30742559 )
2019
35
Access to Hematopoietic Stem Cell Transplantation among Pediatric Patients with Acute Lymphoblastic Leukemia: A Population-based Analysis. ( 30769192 )
2019
36
Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia. ( 30806963 )
2019
37
Higher Reported Lung Dose Received during Total Body Irradiation for Allogeneic Hematopoietic Stem Cell Transplantation in Children with Acute Lymphoblastic Leukemia is Associated with Inferior Survival: A Report from the Children's Oncology Group. ( 30807822 )
2019
38
Chimeric Antigen Receptor-modified Donor Lymphocyte Infusion Improves the Survival of Acute Lymphoblastic Leukemia Patients With Relapsed Diseases After Allogeneic Hematopoietic Stem Cell Transplantation. ( 30829725 )
2019
39
A Single-Center Experience With Hematopoietic Stem Cell Transplantation for Pediatric Acute Lymphoblastic Leukemia: A Modest Pitch for Non-Total Body Irradiation Conditioning Regimens. ( 30295587 )
2019
40
Ikaros family zinc-finger 1 mutation is an independent factor for the poor prognosis of adult B-cell acute lymphoblastic leukemia, and allogeneic hematopoietic stem cell transplantation can improve clinical outcomes. ( 29942002 )
2019
41
Paraneoplastic hypereosinophilic syndrome associated with IL3-IgH positive acute lymphoblastic leukemia. ( 30207070 )
2019
42
Allopurinol reverses mercaptopurine-induced hypoglycemia in patients with acute lymphoblastic leukemia. ( 30828444 )
2019
43
Type B Lactic Acidosis: A Rare Initial Presentation of Childhood Acute Lymphoblastic Leukemia. ( 30814800 )
2019
44
Predisposing germline mutations in high hyperdiploid acute lymphoblastic leukemia in children. ( 31102422 )
2019
45
Long-Term Outcomes of Modified St Jude Children's Research Hospital Total Therapy XIIIB and XV Protocols for Thai Children With Acute Lymphoblastic Leukemia. ( 31103474 )
2019
46
Improving brain function of pediatric acute lymphoblastic leukemia patients after induction chemotherapy, a pilot self-contrast study by fractional amplitude of low-frequency fluctuation. ( 31104963 )
2019
47
Identification and Validation of Novel Reference Genes in Acute Lymphoblastic Leukemia for Droplet Digital PCR. ( 31108950 )
2019
48
CD22 CAR T-cell therapy in refractory or relapsed B acute lymphoblastic leukemia. ( 31110217 )
2019
49
ARID5B gene polymorphisms and the risk of childhood acute lymphoblastic leukemia: a meta-analysis. ( 31111395 )
2019
50
Chromosomal microarray analysis is superior in identifying cryptic aberrations in patients with acute lymphoblastic leukemia at diagnosis/relapse as a single assay. ( 31112375 )
2019

Variations for Acute Lymphocytic Leukemia

Expression for Acute Lymphocytic Leukemia

Search GEO for disease gene expression data for Acute Lymphocytic Leukemia.

Pathways for Acute Lymphocytic Leukemia

Pathways related to Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.28 BCR CDKN2A CDKN2B NOTCH1 TP53
2 10.64 CDKN2A CDKN2B TP53
3 10.29 MTHFR SLC19A1 TYMS

GO Terms for Acute Lymphocytic Leukemia

Cellular components related to Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.4 ANKS1B ASNS BCR CDKN2A CDKN2B ETV6

Biological processes related to Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.8 CDKN2A CDKN2B ETV6 NOTCH1 PAX5 TAL1
2 negative regulation of phosphorylation GO:0042326 9.48 CDKN2A CDKN2B
3 definitive hemopoiesis GO:0060216 9.46 BCR TAL1
4 tetrahydrofolate interconversion GO:0035999 9.43 MTHFR TYMS
5 tetrahydrofolate metabolic process GO:0046653 9.4 MTHFR TYMS
6 somatic stem cell division GO:0048103 9.37 CDKN2A NOTCH1
7 response to folic acid GO:0051593 9.32 MTHFR TYMS
8 cell cycle arrest GO:0007050 9.26 CDKN2A CDKN2B NOTCH1 TP53
9 megakaryocyte differentiation GO:0030219 9.16 CDKN2B TAL1
10 replicative senescence GO:0090399 8.8 CDKN2A MME TP53

Molecular functions related to Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cofactor binding GO:0048037 9.26 ASNS TYMS
2 folic acid binding GO:0005542 9.16 SLC19A1 TYMS
3 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.02 ETV6 NOTCH1 PAX5 TAL1 TP53
4 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 8.96 CDKN2A CDKN2B

Sources for Acute Lymphocytic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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