MCID: ACT074
MIFTS: 62

Acute Lymphocytic Leukemia

Categories: Blood diseases, Bone diseases, Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Acute Lymphocytic Leukemia

MalaCards integrated aliases for Acute Lymphocytic Leukemia:

Name: Acute Lymphocytic Leukemia 39 12 77 44 15 74
Acute Lymphoblastic Leukemia 12 15
Precursor Cell Lymphoblastic Leukemia Lymphoma 74

Classifications:



External Ids:

Disease Ontology 12 DOID:9952
ICD9CM 36 204.0
NCIt 51 C3167
SNOMED-CT 69 90151006 91857003
ICD10 34 C91.0 C91.00

Summaries for Acute Lymphocytic Leukemia

MedlinePlus : 44 Leukemia is cancer of the white blood cells. White blood cells help your body fight infection. Your blood cells form in your bone marrow. In leukemia, however, the bone marrow produces abnormal white blood cells. These cells crowd out the healthy blood cells, making it hard for blood to do its work. In acute lymphocytic leukemia (ALL), also called acute lymphoblastic leukemia, there are too many of specific types of white blood cells called lymphocytes or lymphoblasts. ALL is the most common type of cancer in children. Possible risk factors for ALL include being male, being white, previous chemotherapy treatment, exposure to radiation, and for adults, being older than 70. Symptoms of ALL include: Weakness or feeling tired Fever Easy bruising or bleeding Bleeding under the skin Shortness of breath Weight loss or loss of appetite Pain in the bones or stomach Pain or a feeling of fullness below the ribs Painless lumps in the neck, underarm, stomach, or groin Tests that examine the blood and bone marrow diagnose ALL. Treatments include chemotherapy, radiation therapy, stem cell transplants, and targeted therapy. Targeted therapy uses substances that attack cancer cells without harming normal cells. Once the leukemia is in remission, you need additional treatment to make sure that it does not come back. NIH: National Cancer Institute

MalaCards based summary : Acute Lymphocytic Leukemia, also known as acute lymphoblastic leukemia, is related to adult acute lymphocytic leukemia and acute t cell leukemia, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Acute Lymphocytic Leukemia is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are Pathways in cancer and Oncogene Induced Senescence. The drugs Mercaptopurine and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone, and related phenotypes are homeostasis/metabolism and growth/size/body region

Disease Ontology : 12 A lymphoblastic leukemia that is characterized by over production of lymphoblasts.

Wikipedia : 77 Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the... more...

Related Diseases for Acute Lymphocytic Leukemia

Diseases in the Lymphocytic Leukemia family:

Leukemia, Chronic Lymphocytic 2 Leukemia, Chronic Lymphocytic
Leukemia, Chronic Lymphocytic 1 Leukemia, Chronic Lymphocytic 3
Leukemia, Chronic Lymphocytic 4 Leukemia, Chronic Lymphocytic 5
Acute Lymphocytic Leukemia Adult Acute Lymphocytic Leukemia

Diseases related to Acute Lymphocytic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 700)
# Related Disease Score Top Affiliating Genes
1 adult acute lymphocytic leukemia 34.5 CDKN2B MTHFR TYMS
2 acute t cell leukemia 33.9 NOTCH1 TAL1 TAL2
3 leukemia, acute lymphoblastic 33.3 BCR ETV6 MME PAX5 TPMT
4 acute leukemia 32.8 ETV6 MTHFR PAX5 TAL1
5 acute lymphoblastic leukemia, childhood 32.7 ASNS CDKN2A CDKN2B ETV6 MME MTHFR
6 leukemia 32.5 BCR CDKN2B-AS1 ETV6 NOTCH1 TAL1 TAL2
7 precursor t-cell acute lymphoblastic leukemia 32.1 ASNS BCR CDKN2A CDKN2B ETV6 NOTCH1
8 leukemia, acute lymphoblastic 3 32.1 BCR CDKN2A CDKN2B ETV6 MME PAX5
9 lymphocytic leukemia 31.8 BCR ETV6 MME NOTCH1 PAX5 TAL1
10 b-cell lymphomas 30.6 CDKN2A MME PAX5 TP53
11 lymphoblastic lymphoma 30.5 CDKN2B MME NOTCH1 TAL1
12 childhood leukemia 30.5 ETV6 MTHFR TP53
13 grade iii astrocytoma 30.4 CDKN2A CDKN2B TP53
14 oligodendroglioma 30.4 CDKN2A CDKN2B TP53
15 leukemia, chronic lymphocytic 30.3 BCR NOTCH1 PAX5 TP53
16 cll/sll 30.3 MME PAX5 TP53
17 spitz nevus 30.3 CDKN2A TP53
18 mantle cell lymphoma 30.1 CDKN2A MME PAX5 TP53
19 t-cell leukemia 30.0 CDKN2A NOTCH1 TAL1 TP53
20 lymphoma, non-hodgkin, familial 30.0 BCR CDKN2B MME NOTCH1 PAX5 TP53
21 leukemia, acute myeloid 29.9 BCR CDKN2B CDKN2B-AS1 ETV6 MME TP53
22 osteogenic sarcoma 29.3 CDKN2B-AS1 TP53 XIST
23 nasopharyngeal carcinoma 29.3 CDKN2A CDKN2B-AS1 TP53 XIST
24 b-cell childhood acute lymphoblastic leukemia 12.7
25 b-cell adult acute lymphocytic leukemia 12.3
26 t-cell adult acute lymphocytic leukemia 12.3
27 acute lymphoblastic leukemia congenital sporadic aniridia 12.3
28 t-cell childhood acute lymphocytic leukemia 12.3
29 null-cell leukemia 11.8
30 medulloblastoma 11.6
31 lymphoblastic leukemia, acute, with lymphomatous features 11.6
32 ataxia-telangiectasia 11.5
33 prostate cancer 10.6
34 caronte 10.5
35 methotrexate toxicity or dose selection 10.5 MTHFR SLC19A1
36 fallopian tube endometrioid adenocarcinoma 10.5 CDKN2A MME
37 hemifacial spasm 10.5 MTHFR TYMS
38 splenic diffuse red pulp small b-cell lymphoma 10.4 NOTCH1 TP53
39 tenosynovial giant cell tumor 10.4 CDKN2A CDKN2B
40 invasive bladder transitional cell carcinoma 10.4 NOTCH1 TP53
41 malignant leydig cell tumor 10.4 MME PAX5
42 pancytopenia 10.4
43 bone squamous cell carcinoma 10.4 CDKN2A NOTCH1
44 bladder squamous cell carcinoma 10.4 CDKN2A TP53
45 keratinizing squamous cell carcinoma 10.4 CDKN2A TP53
46 hepatitis 10.4
47 chromosomal triplication 10.4
48 lymphoma 10.4
49 scrotal carcinoma 10.4 CDKN2A CDKN2B TP53
50 cardia cancer 10.4 MTHFR TP53 TYMS

Graphical network of the top 20 diseases related to Acute Lymphocytic Leukemia:



Diseases related to Acute Lymphocytic Leukemia

Symptoms & Phenotypes for Acute Lymphocytic Leukemia

UMLS symptoms related to Acute Lymphocytic Leukemia:


angina pectoris, edema, chest pain

MGI Mouse Phenotypes related to Acute Lymphocytic Leukemia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.25 ANKS1B BCR CDKN2A CDKN2B ETV6 MME
2 growth/size/body region MP:0005378 10.23 ASNS BCR CDKN2A ETV6 MTHFR NOTCH1
3 hematopoietic system MP:0005397 10.21 ASNS BCR CDKN2A CDKN2B ETV6 NOTCH1
4 immune system MP:0005387 10.07 BCR CDKN2A CDKN2B ETV6 MME NOTCH1
5 integument MP:0010771 9.97 CDKN2A CDKN2B ETV6 MME MTHFR NOTCH1
6 mortality/aging MP:0010768 9.97 ANKS1B BCR CDKN2A CDKN2B ETV6 MTHFR
7 liver/biliary system MP:0005370 9.8 BCR CDKN2A MME MTHFR NOTCH1 SLC19A1
8 neoplasm MP:0002006 9.43 CDKN2A CDKN2B ETV6 NOTCH1 PAX5 TP53
9 nervous system MP:0003631 9.36 ANKS1B ASNS BCR CDKN2A MTHFR NOTCH1

Drugs & Therapeutics for Acute Lymphocytic Leukemia

Drugs for Acute Lymphocytic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 654)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mercaptopurine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-44-2 667490
2
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 302-25-0
3
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
4
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 2068-78-2, 57-22-7 5978
5
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1959-05-2, 59-05-2 126941
6
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 135968-09-1
7
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
8
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2921-57-5
9
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 6055-19-2, 50-18-0 2907
10
Cytarabine Approved, Experimental, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 147-94-4, 65-46-3 6253
11
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 174722-31-7 10201696
12
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1177-87-3
13
Sargramostim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 123774-72-1, 83869-56-1
14
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-02-2 5743
15
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58957-92-9 42890
16
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-05-9 6006 143
17
Dasatinib Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 302962-49-8 3062316
18
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53-03-2 5865
19
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 20830-81-3 30323
20
Teniposide Approved Phase 4,Phase 3,Phase 2,Not Applicable 29767-20-2 34698
21
Hydrocortisone acetate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-03-3
22
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-23-7 5754
23
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 65271-80-9 4212
24
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 23214-92-8 31703
25
Pegaspargase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 130167-69-0
26
Thioguanine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 154-42-7 2723601
27
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 75607-67-9, 21679-14-1 30751
28
Vindesine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 59917-39-4, 53643-48-4 40839
29
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 33419-42-0 36462
30
Cladribine Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 4291-63-8 20279
31
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 3778-73-2 3690
32
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 22916-47-8 4189
33
Thiotepa Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 52-24-4 5453
34
Busulfan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 55-98-1 2478
35
Epirubicin Approved Phase 4,Phase 3,Phase 2 56420-45-2 41867
36
Micafungin Approved, Investigational Phase 4,Phase 2 235114-32-6 477468 3081921
37
Posaconazole Approved, Investigational, Vet_approved Phase 4,Not Applicable 171228-49-2 147912
38
Dopamine Approved Phase 4,Not Applicable 62-31-7, 51-61-6 681
39
Methylphenidate Approved, Investigational Phase 4,Not Applicable 113-45-1 4158
40
Oprelvekin Approved, Investigational Phase 4 145941-26-0
41
inotuzumab ozogamicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 635715-01-4
42
Azacitidine Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 320-67-2 9444
43
Decitabine Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 2353-33-5 451668
44
Morphine Approved, Investigational Phase 4,Phase 3,Not Applicable 57-27-2 5288826
45
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2 1397-89-3 14956 5280965
46
Nicotine Approved Phase 4 54-11-5 942 89594
47
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 59-30-3 6037
48
Calcium Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7440-70-2 271
49
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2 50-14-6 5280793
50
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 1406-16-2

Interventional clinical trials:

(show top 50) (show all 1867)
# Name Status NCT ID Phase Drugs
1 German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT00198978 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Cytarabine;Idarubicin;Granulocyte-Colony-Stimulating Factor;Mercaptopurine;Methotrexate;Rituximab;HDARAC;Vincristine;Depocyte;Asparaginase
2 Low-dose Chemotherapy Combine With Tyrosine Kinase Inhibitor to Treat ph+ Acute Lymphoblastic Leukemia Patients Unknown status NCT02690922 Phase 4 Dasatinib;prednisone;dexamethasone;methotrexate
3 Treatment Protocol of Children With Philadelphia Chromosome Negative High Risk Acute Lymphoblastic Leukemia Unknown status NCT01990807 Phase 4 Idarubicin(IDA)
4 The GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia Unknown status NCT00846703 Phase 4 6-mercaptopurine, Methotrexate;6-mercaptopurine, Methotrexate, Vincristine, Dexamethasone
5 Treatment of High Risk Adult Acute Lymphoblastic Leukemia Unknown status NCT00853008 Phase 4 Vincristine;Daunorubicin;Prednisone;Mitoxantrone;Cytosine Arabinoside;Dexamethasone;Methotrexate (MTX);Cytarabine;ASP;Mercaptopurine;Teniposide;Hydrocortisone
6 Medical Research Council (MRC) Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003 Unknown status NCT00222612 Phase 4 Standard childhood UK ALL protocol;Intensified treatment including Capizzi maintenance
7 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (07/2003) Unknown status NCT00198991 Phase 4 Cyclophosphamide;Dexamethasone;Vincristine;daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Prednisolone;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Cladribine
8 Malaysia-Singapore Acute Lymphoblastic Leukemia 2010 Study Unknown status NCT02894645 Phase 4 Prednisolone;Dexamethasone;L-Asparaginase;Vincristine;Methotrexate;Daunorubicin;Doxorubicin;Cyclophosphamide;Cytarabine;6-Mercaptopurine;Thioguanine;Fludarabine;Imatinib
9 Poly(Ethylene Glycol)(PEG)-Asparaginase During Two Treatment Courses Unknown status NCT00192673 Phase 4 PEG-asparaginase
10 HD-Idarubicin/Etoposide Intensified Conditioning Regimen Allo-HSCT for Adult ALL Unknown status NCT01873807 Phase 4 IDA;CTX;VP-16
11 Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults Unknown status NCT00797810 Phase 4 Rituximab
12 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4 Growth Hormone
13 Pulses of Vincristine and Dexamethasone in BFM Protocols for Children With Acute Lymphoblastic Leukemia Completed NCT00411541 Phase 4 vincristine;dexamethasone
14 Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia Completed NCT00199095 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone;Idarubicin;Ifosfamide;Methotrexate;Mercaptopurine;VM26;Vincristine
15 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (06/99) Completed NCT00199056 Phase 4 Dexamethasone / Prednisolone;Cyclophosphamide;Methotrexate;Vincristine / Vindesine;Daunorubicin;Asparaginase;G-CSF;Cytarabine;6-Mercaptopurine;VP16;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Ifosfamide
16 Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia Completed NCT01358253 Phase 4 Cyclophosphamide;Doxorubicin;Vincristine;Dexamethasone;Cytarabine;Methotrexate;Rituximab;6-Mercaptopurine;Prednisone;L-asparaginase
17 LAL-AR-N-2005:Study Treatment for Children High Risk Acute Lymphoblastic Leukemia Completed NCT00526409 Phase 4 Prednisolone;Daunorubicin;Vincristine;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside
18 PETHEMA LAL-RI/96: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Completed NCT00494897 Phase 4 Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin;Mercaptopurine;Prednisone;Vincristine;Methotrexate
19 LAL-Ph-2000: Treatment of Acute Lymphoblastic Leukemia Chromosome Philadelphia Positive Completed NCT00526305 Phase 4 Vincristine;Daunorubicin;Prednisone;L-Asparaginase;Mitoxantrone;Cytosine Arabinoside;Hydrocortisone;Mercaptopurine;Cyclophosphamide;Dexamethasone
20 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93) Completed NCT00199069 Phase 4 Asparaginase;Vincristine;Daunorubicin, Adriamycin;Cyclophosphamide;Ifosfamide;Cytarabine;Mitoxantrone;Methotrexate;6-Mercaptopurine;6-Thioguanine;VM26;Dexamethasone / Prednisolone
21 Trial for Treatment of Adult Patients With Standard Risk Acute Lymphoblastic Leukemia With Chemotherapy and Rituximab Completed NCT00199004 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Vincristine;Daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Adriamycin;Thioguanine;VM26;Rituximab
22 Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome Completed NCT01200355 Phase 4 micafungin;posaconazole
23 ALL-REZ BFM 2002: Multi-Center Study for Children With Relapsed Acute Lymphoblastic Leukemia Completed NCT00114348 Phase 4
24 Learning Impairments Among Survivors of Childhood Cancer Completed NCT00576472 Phase 4 Methylphenidate
25 Effect of rhIL-11 in Patients With Thrombocytopenia for Childhood ALL Completed NCT02314273 Phase 4 rhIL-11
26 LAL-BR/2001: Study Treatment to Low Risk ALL Completed NCT00526175 Phase 4 Prednisone;Vincristine;Daunorubicin;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside;Mercaptopurine;VP-16
27 The Study on the Pharmacokinetics of PEG-rhG-CSF in Children and Adolescents Completed NCT02953730 Phase 4 PEG-rhG-CSF
28 Trial for the Treatment of Newly Diagnosed Mature B-Cell Acute Lymphoblastic Leukemia (B-ALL), Burkitt's Non-Hodgkin's Lymphoma (NHL) and Other High-grade Lymphoma in Adults Completed NCT00199082 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone/Prednisolone;VP16;Ifosfamide;Methotrexate;G-CSF;Rituximab;Vincristine/Vindesine
29 German Multicenter Trial for the Treatment of Newly Diagnosed T-lymphoblastic Lymphoma in Adults Completed NCT00199017 Phase 4 Dexamethasone/Prednisolone;Cyclophosphamide;Vincristine;Daunorubicin;Asparaginase;G-CSF;Mercaptopurine;Cytarabine;Methotrexate;VP16;Vindesine;Adriamycin;Thioguanine;HDARAC;Cladribine
30 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4 cyclophosphamide;thiotepa
31 Nilotinib in Newly Diagnosed Adult Philadelphia Chromosome & /or BCR-ABL Positive Chronic Myeloid Leukaemia in Chronic Phase Completed NCT01061177 Phase 4 Nilotinib
32 Identification of New Immune Factors Specific of Relapse in Childhood B Lineage Acute Lymphoblastic Leukemia Recruiting NCT02618109 Phase 4
33 Protocol For the Treatment Acute Lymphoblastic Leukemia With Ph 'Negative in Elderly Patients (> 55 Years) Recruiting NCT01366898 Phase 4 Dexamethasona, Idarubicine, ARA-C, Methotrexate
34 A Study Of Two Inotuzumab Ozogamicin Doses in Relapsed/ Refractory Acute Lymphoblastic Leukemia Transplant Eligible Patients Recruiting NCT03677596 Phase 4 inotuzumab ozogamicin-dose level 2;Inotuzumab ozogamicin-dose level 1
35 Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVE Recruiting NCT01491763 Phase 4 Imatinib
36 Study on Two Different Formulations of 6-mercaptopurine. Tablet Versus Oral Liquid Recruiting NCT01906671 Phase 4 Xaluprine;Puri-Nethol
37 PETHEMA LAL-07FRAIL: All Treatment In Fragile Patients Ph' Negative Over 55 Years Recruiting NCT01358201 Phase 4 vINCRISTINE;Dexamethasone;Methotrexate;Cytosine arabinoside
38 ALL SCTped FORUM - Pharmacogenomic Study (add-on Study) Recruiting NCT02670564 Phase 4
39 Pethema LAL-RI/2008: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Recruiting NCT02036489 Phase 4 Vincristine;Daunorubicin;Prednisone;L-asparaginase;Ciclophosphamide;Metotrexate;ARA-C;Hidrocortisone;Mercaptopurine;VP-16;Dexametasone
40 ATG Based Conditioning Regimen in HLA Related HSCT for Aggressive T-cell Tumors Recruiting NCT02938741 Phase 4 Anti-human Thymoglobulin;Placebo
41 G-CSF Alone or Combination With GM-CSF on Prevention and Treatment of Infection in Children With Malignant Tumor Recruiting NCT02933333 Phase 4
42 A Clinical Trial of Decitabine in Relapsed or Refractory T-lymphoblastic Lymphoma Recruiting NCT03558412 Phase 4 Decitabine
43 Vaccinating Children After Chemotherapy Active, not recruiting NCT02447718 Phase 4
44 A Randomized Phase IV Control Trial of Single High Dose Oral Vitamin D3 in Pediatric Patients Undergoing HSCT Enrolling by invitation NCT03176849 Phase 4
45 ProphyALL - Study on the Safety of Liposomal Amphotericin B to Prevent Antifungal Infections in Elderly Patients With Acute Lymphoblastic Leukemia Terminated NCT00386997 Phase 4 liposomal amphotericin B (AmBisome®)
46 Atomoxetine for Children With Acquired Attentional Disorders Following Completion of Chemotherapy for ALL Terminated NCT00299234 Phase 4 Atomoxetine
47 Haplo-identical HSCT Versus Chemotherapy for Adult Acute Lymphoblastic Leukemia Patients Unknown status NCT02042690 Phase 3 Chemotherapy
48 Phase III Study of Vincristine Sulfate Liposome For Injection In Adults With Naïve Acute Lymphoblastic Leukemia Unknown status NCT02072785 Phase 3 Vincristine Sulfate Liposome;Vincristine Sulfate
49 Treatment of Acute Lymphoblastic Leukemia or Aggressive Lymphoma With Relapse in Central Nervous System With Depocyt Unknown status NCT00199108 Phase 2, Phase 3 Depocyt;Dexamethasone
50 High-Dose Methotrexate (MTX) for Adult Acute Lymphoblastic Leukemia (ALL) Unknown status NCT00131027 Phase 3 Cyclophosphamide;Daunorubicin;Vincristine;Prednisolone;L-asparaginase;Cytarabine;Etoposide;Dexamethasone;Methotrexate;Mercaptopurine;Doxorubicin;Methotrexate

Search NIH Clinical Center for Acute Lymphocytic Leukemia

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Genetic Tests for Acute Lymphocytic Leukemia

Anatomical Context for Acute Lymphocytic Leukemia

MalaCards organs/tissues related to Acute Lymphocytic Leukemia:

42
T Cells, B Cells, Bone, Bone Marrow, Myeloid, Testes, Kidney

Publications for Acute Lymphocytic Leukemia

Articles related to Acute Lymphocytic Leukemia:

(show top 50) (show all 3541)
# Title Authors Year
1
Maternal prenatal exposure to environmental factors and risk of childhood acute lymphocytic leukemia: A hospital-based case-control study in China. ( 30579239 )
2019
2
Novel EZH2 mutation in a patient with secondary B-cell acute lymphocytic leukemia after deletion 5q myelodysplastic syndrome treated with lenalidomide: A case report. ( 30608448 )
2019
3
FUSE binding protein 1 (FUBP1) expression is upregulated by T-cell acute lymphocytic leukemia protein 1 (TAL1) and required for efficient erythroid differentiation. ( 30653565 )
2019
4
PIM inhibitor SMI-4a induces cell apoptosis in B-cell acute lymphocytic leukemia cells via the HO-1-mediated JAK2/STAT3 pathway. ( 30658101 )
2019
5
Intractable anal pain in B-cell acute lymphocytic leukemia patients: treatment options. ( 30671206 )
2019
6
CD4+ cells as a potential biomarker for cytomegalovirus retinitis in children with acute lymphocytic leukemia. ( 30681505 )
2019
7
Allogeneic blood transfusion in 163 children with acute lymphocytic leukemia (a STROBE-compliant article). ( 30762790 )
2019
8
Poor Penetration of Existing Effective Chemoimmunotherapy for the Treatment of Older Patients With Newly Diagnosed Acute Lymphocytic Leukemia (ALL) or Refractory/Relapsed ALL. ( 30763202 )
2019
9
Insulin-dependent diabetes: A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia. ( 30216644 )
2019
10
Bilateral trifocal IOL implantation in a pediatric case of cataract following steroid-therapy for acute lymphoblastic leukemia. ( 30555958 )
2019
11
Congenital B-cell Acute Lymphoblastic Leukemia with Congenital Rubella Infection. ( 30806367 )
2019
12
Monitoring of cytomegalovirus infection in non-transplant pediatric acute lymphoblastic leukemia patients during chemotherapy. ( 30681620 )
2019
13
Development of acute lymphoblastic leukemia following treatment for acute myeloid leukemia in children with Down syndrome: A case report and retrospective review of Children's Oncology Group acute myeloid leukemia trials. ( 30908863 )
2019
14
Dasatinib and low-intensity chemotherapy for Philadelphia chromosome-positive acute lymphoblastic leukemia in a child with Down syndrome. ( 30663211 )
2019
15
Feasibility and Potential Benefits of an Exercise Intervention in a Male With Down Syndrome Undergoing High-Dose Chemotherapy for Acute Lymphoblastic Leukemia: A Case Report. ( 30795696 )
2019
16
Posterior reversible encephalopathy syndrome in children with acute lymphoblastic leukemia: Experience of a single center using BFM protocols. ( 30868749 )
2019
17
Invasive fusariosis masquerading as extramedullary disease in rapidly progressive acute lymphoblastic leukemia. ( 30900813 )
2019
18
Growth hormone deficiency and neurocognitive function in adult survivors of childhood acute lymphoblastic leukemia. ( 30690723 )
2019
19
Hematopoietic Stem Cell Transplantation Does Not Improve the Poor Outcome of Children With Hypodiploid Acute Lymphoblastic Leukemia: A Report From Children's Oncology Group. ( 30742559 )
2019
20
Access to Hematopoietic Stem Cell Transplantation among Pediatric Patients with Acute Lymphoblastic Leukemia: A Population-based Analysis. ( 30769192 )
2019
21
Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia. ( 30806963 )
2019
22
Higher Reported Lung Dose Received during Total Body Irradiation for Allogeneic Hematopoietic Stem Cell Transplantation in Children with Acute Lymphoblastic Leukemia is Associated with Inferior Survival: A Report from the Children's Oncology Group. ( 30807822 )
2019
23
Chimeric Antigen Receptor-modified Donor Lymphocyte Infusion Improves the Survival of Acute Lymphoblastic Leukemia Patients With Relapsed Diseases After Allogeneic Hematopoietic Stem Cell Transplantation. ( 30829725 )
2019
24
Paraneoplastic hypereosinophilic syndrome associated with IL3-IgH positive acute lymphoblastic leukemia. ( 30207070 )
2019
25
Allopurinol reverses mercaptopurine-induced hypoglycemia in patients with acute lymphoblastic leukemia. ( 30828444 )
2019
26
Type B Lactic Acidosis: A Rare Initial Presentation of Childhood Acute Lymphoblastic Leukemia. ( 30814800 )
2019
27
Successful Treatment of Pyoderma Gangrenosum With Skin Grafting in a Patient With Acute Lymphoblastic Leukemia. ( 30882508 )
2019
28
Intrathecal dose intensification by CNS status at diagnosis in the treatment of children with acute lymphoblastic leukemia. ( 30885098 )
2019
29
A systematic literature review and meta-analysis of minimal residual disease as a prognostic indicator in adult B-cell acute lymphoblastic leukemia. ( 30890593 )
2019
30
Timosaponin A‑III induces autophagy of T‑cell acute lymphoblastic leukemia Jurkat cells via inhibition of the PI3K/Akt/mTOR pathway. ( 30896824 )
2019
31
Umbilical cord blood‑derived Helios‑positive regulatory T cells promote angiogenesis in acute lymphoblastic leukemia in mice via CCL22 and the VEGFA‑VEGFR2 pathway. ( 30896872 )
2019
32
Absolute Lymphocyte Count at End of Induction as a Surrogate Marker for Minimal Residual Disease in T Acute Lymphoblastic Leukemia: A pilot study. ( 30898988 )
2019
33
Metabolomics of Neonatal Blood Spots Reveal Distinct Phenotypes of Pediatric Acute Lymphoblastic Leukemia and Potential Effects of Early-life Nutrition. ( 30904619 )
2019
34
Bone Loss in Pediatric Survivors of Acute Lymphoblastic Leukemia. ( 30911254 )
2019
35
WP1130 reveals USP24 as a novel target in T-cell acute lymphoblastic leukemia. ( 30911287 )
2019
36
The effect of adopting pediatric protocols in adolescents and young adults with acute lymphoblastic leukemia in pediatric vs adult centers: An IMPACT Cohort study. ( 30912628 )
2019
37
A cross-sectional follow-up study of physical morbidities, neurocognitive function, and attention problems in post-treatment childhood acute lymphoblastic leukemia survivors. ( 30913362 )
2019
38
Dasatinib as an investigational drug for the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia in adults. ( 30916583 )
2019
39
Relapsed B-Acute Lymphoblastic Leukemia with Aberrant Myeloperoxidase Expression Following CAR T-cell Therapy: A Diagnostic Challenge. ( 30916805 )
2019
40
Absolute count of leukemic blasts in cerebrospinal fluid as detected by flow cytometry is a relevant prognostic factor in children with acute lymphoblastic leukemia. ( 30840196 )
2019
41
Reduced vs. standard dose native E. coli-asparaginase therapy in childhood acute lymphoblastic leukemia: long-term results of the randomized trial Moscow-Berlin 2002. ( 30840197 )
2019
42
Osteonecrosis in Children and Adolescents With Acute Lymphoblastic Leukemia: Early Diagnosis and New Treatment Strategies. ( 30842156 )
2019
43
Correction: Inotuzumab ozogamicin in pediatric patients with relapsed/refractory acute lymphoblastic leukemia. ( 30842605 )
2019
44
PAX5 biallelic genomic alterations define a novel subgroup of B-cell precursor acute lymphoblastic leukemia. ( 30842609 )
2019
45
Clinician Concepts of Cure in Adult Relapsed and Refractory Philadelphia-Negative B Cell Precursor Acute Lymphoblastic Leukemia: A Delphi Study. ( 30847777 )
2019
46
No evidence that G6PD deficiency affects the efficacy or safety of daunorubicin in acute lymphoblastic leukemia induction therapy. ( 30848065 )
2019
47
A genetic variant in miR-100 is a protective factor of childhood acute lymphoblastic leukemia. ( 30848099 )
2019
48
Decreased Early Mortality in Young Adult Patients With Acute Lymphoblastic Leukemia Treated at Specialized Cancer Centers in California. ( 30849003 )
2019
49
Ex vivo resistance in childhood acute lymphoblastic leukemia: Correlations between BCRP, MRP1, MRP4 and MRP5 ABC transporter expression and intracellular methotrexate polyglutamate accumulation. ( 30849662 )
2019
50
A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia. ( 30850736 )
2019

Variations for Acute Lymphocytic Leukemia

Expression for Acute Lymphocytic Leukemia

Search GEO for disease gene expression data for Acute Lymphocytic Leukemia.

Pathways for Acute Lymphocytic Leukemia

Pathways related to Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.28 BCR CDKN2A CDKN2B NOTCH1 TP53
2 10.64 CDKN2A CDKN2B TP53
3 10.29 MTHFR SLC19A1 TYMS

GO Terms for Acute Lymphocytic Leukemia

Cellular components related to Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.4 ANKS1B ASNS BCR CDKN2A CDKN2B ETV6

Biological processes related to Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.8 CDKN2A CDKN2B ETV6 NOTCH1 PAX5 TAL1
2 negative regulation of phosphorylation GO:0042326 9.48 CDKN2A CDKN2B
3 definitive hemopoiesis GO:0060216 9.46 BCR TAL1
4 tetrahydrofolate interconversion GO:0035999 9.43 MTHFR TYMS
5 tetrahydrofolate metabolic process GO:0046653 9.4 MTHFR TYMS
6 somatic stem cell division GO:0048103 9.37 CDKN2A NOTCH1
7 response to folic acid GO:0051593 9.32 MTHFR TYMS
8 cell cycle arrest GO:0007050 9.26 CDKN2A CDKN2B NOTCH1 TP53
9 megakaryocyte differentiation GO:0030219 9.16 CDKN2B TAL1
10 replicative senescence GO:0090399 8.8 CDKN2A MME TP53

Molecular functions related to Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cofactor binding GO:0048037 9.26 ASNS TYMS
2 folic acid binding GO:0005542 9.16 SLC19A1 TYMS
3 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.02 ETV6 NOTCH1 PAX5 TAL1 TP53
4 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 8.96 CDKN2A CDKN2B

Sources for Acute Lymphocytic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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