MCID: ACT074
MIFTS: 63

Acute Lymphocytic Leukemia

Categories: Blood diseases, Bone diseases, Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Acute Lymphocytic Leukemia

MalaCards integrated aliases for Acute Lymphocytic Leukemia:

Name: Acute Lymphocytic Leukemia 38 12 76 43 15 73
Acute Lymphoblastic Leukemia 12 15
Precursor Cell Lymphoblastic Leukemia Lymphoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9952
ICD10 33 C91.0 C91.00
ICD9CM 35 204.0
NCIt 50 C3167
SNOMED-CT 68 90151006 91857003

Summaries for Acute Lymphocytic Leukemia

MedlinePlus : 43 Leukemia is cancer of the white blood cells. White blood cells help your body fight infection. Your blood cells form in your bone marrow. In leukemia, however, the bone marrow produces abnormal white blood cells. These cells crowd out the healthy blood cells, making it hard for blood to do its work. In acute lymphocytic leukemia (ALL), also called acute lymphoblastic leukemia, there are too many of specific types of white blood cells called lymphocytes or lymphoblasts. ALL is the most common type of cancer in children. Possible risk factors for ALL include being male, being white, previous chemotherapy treatment, exposure to radiation, and for adults, being older than 70. Symptoms of ALL include: Weakness or feeling tired Fever Easy bruising or bleeding Bleeding under the skin Shortness of breath Weight loss or loss of appetite Pain in the bones or stomach Pain or a feeling of fullness below the ribs Painless lumps in the neck, underarm, stomach, or groin Tests that examine the blood and bone marrow diagnose ALL. Treatments include chemotherapy, radiation therapy, stem cell transplants, and targeted therapy. Targeted therapy uses substances that attack cancer cells without harming normal cells. Once the leukemia is in remission, you need additional treatment to make sure that it does not come back. NIH: National Cancer Institute

MalaCards based summary : Acute Lymphocytic Leukemia, also known as acute lymphoblastic leukemia, is related to b-cell childhood acute lymphoblastic leukemia and adult acute lymphocytic leukemia, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Acute Lymphocytic Leukemia is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are Pathways in cancer and Transcriptional misregulation in cancer. The drugs Arranon and Blincyto have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone, and related phenotypes are homeostasis/metabolism and growth/size/body region

Disease Ontology : 12 A lymphoblastic leukemia that is characterized by over production of lymphoblasts.

Wikipedia : 76 Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the... more...

Related Diseases for Acute Lymphocytic Leukemia

Diseases in the Lymphocytic Leukemia family:

Leukemia, Chronic Lymphocytic 2 Leukemia, Chronic Lymphocytic
Leukemia, Chronic Lymphocytic 1 Leukemia, Chronic Lymphocytic 3
Leukemia, Chronic Lymphocytic 4 Leukemia, Chronic Lymphocytic 5
Acute Lymphocytic Leukemia Adult Acute Lymphocytic Leukemia

Diseases related to Acute Lymphocytic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 636)
# Related Disease Score Top Affiliating Genes
1 b-cell childhood acute lymphoblastic leukemia 34.5 ETV6 RUNX1
2 adult acute lymphocytic leukemia 34.2 CDKN2B MTHFR TYMS
3 acute t cell leukemia 33.5 NOTCH1 TAL1 TAL2
4 leukemia, acute lymphoblastic 33.0 BCR ETV6 MME PAX5 RUNX1 TPMT
5 acute lymphoblastic leukemia, childhood 32.8 CDKN2A CDKN2B ETV6 MME MTHFR NR3C1
6 childhood leukemia 32.5 ETV6 MTHFR RUNX1 TP53
7 acute leukemia 32.5 ETV6 MTHFR PAX5 RUNX1 TAL1
8 leukemia 32.4 BCR CDKN2B-AS1 ETV6 NOTCH1 RUNX1 TAL1
9 precursor t-cell acute lymphoblastic leukemia 32.3 BCR CDKN2A CDKN2B ETV6 NOTCH1 TAL1
10 leukemia, acute lymphoblastic 3 31.9 BCR CDKN2A CDKN2B ETV6 MME PAX5
11 lymphocytic leukemia 31.6 BCR ETV6 MME NOTCH1 PAX5 RUNX1
12 b-cell lymphomas 30.4 CDKN2A MME PAX5 TP53
13 myeloid leukemia 30.4 BCR ETV6 RUNX1 TP53
14 lymphoblastic lymphoma 30.3 CDKN2B MME NOTCH1 TAL1
15 grade iii astrocytoma 30.2 CDKN2A CDKN2B TP53
16 central nervous system leukemia 30.2 MME RUNX1
17 oligodendroglioma 30.1 CDKN2A CDKN2B TP53
18 leukemia, chronic myeloid 30.0 BCR CDKN2B ETV6 RUNX1
19 spitz nevus 30.0 CDKN2A TP53
20 lymphoma, non-hodgkin, familial 29.9 BCR CDKN2B MME NOTCH1 PAX5 TP53
21 leukemia, acute myeloid 29.8 BCR CDKN2B CDKN2B-AS1 ETV6 MME RUNX1
22 basal cell carcinoma 29.7 CDKN2A CDKN2B-AS1 MME TP53
23 t-cell leukemia 29.6 CDKN2A NOTCH1 TAL1 TP53
24 nasopharyngeal carcinoma 29.3 CDKN2A CDKN2B-AS1 TP53 XIST
25 osteogenic sarcoma 29.3 CDKN2B-AS1 TP53 XIST
26 b-cell adult acute lymphocytic leukemia 12.3
27 t-cell adult acute lymphocytic leukemia 12.3
28 acute lymphoblastic leukemia congenital sporadic aniridia 12.3
29 t-cell childhood acute lymphocytic leukemia 12.3
30 null-cell leukemia 11.8
31 lymphoblastic leukemia, acute, with lymphomatous features 11.6
32 medulloblastoma 11.6
33 ataxia-telangiectasia 11.5
34 prostate cancer 10.6
35 carney complex, type 1 10.5
36 caronte 10.5
37 pancytopenia 10.4
38 peripheral nervous system disease 10.3
39 fallopian tube endometrioid adenocarcinoma 10.3 CDKN2A MME
40 hemifacial spasm 10.3 MTHFR TYMS
41 lymphoma 10.3
42 hemophagocytic lymphohistiocytosis 10.3
43 histiocytic sarcoma 10.3
44 splenic diffuse red pulp small b-cell lymphoma 10.3 NOTCH1 TP53
45 tenosynovial giant cell tumor 10.2 CDKN2A CDKN2B
46 invasive bladder transitional cell carcinoma 10.2 NOTCH1 TP53
47 cll/sll 10.2 MME PAX5 TP53
48 spondylocarpotarsal synostosis syndrome 10.2
49 body mass index quantitative trait locus 1 10.2
50 hepatitis 10.2

Graphical network of the top 20 diseases related to Acute Lymphocytic Leukemia:



Diseases related to Acute Lymphocytic Leukemia

Symptoms & Phenotypes for Acute Lymphocytic Leukemia

UMLS symptoms related to Acute Lymphocytic Leukemia:


angina pectoris, edema, chest pain

MGI Mouse Phenotypes related to Acute Lymphocytic Leukemia:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.33 ANKS1B BCR CDKN2A CDKN2B ETV6 MME
2 growth/size/body region MP:0005378 10.27 BCR CDKN2A ETV6 MTHFR NOTCH1 NR3C1
3 hematopoietic system MP:0005397 10.26 BCR CDKN2A CDKN2B ETV6 NOTCH1 NR3C1
4 cellular MP:0005384 10.25 BCR CDKN2A CDKN2B ETV6 NOTCH1 NR3C1
5 immune system MP:0005387 10.17 BCR CDKN2A CDKN2B ETV6 MME NOTCH1
6 mortality/aging MP:0010768 10.17 ANKS1B BCR CDKN2A CDKN2B ETV6 MTHFR
7 integument MP:0010771 10.1 CDKN2A CDKN2B ETV6 MME MTHFR NOTCH1
8 liver/biliary system MP:0005370 9.97 BCR CDKN2A MME MTHFR NOTCH1 NR3C1
9 nervous system MP:0003631 9.93 ANKS1B BCR CDKN2A MTHFR NOTCH1 NR3C1
10 neoplasm MP:0002006 9.8 CDKN2A CDKN2B ETV6 NOTCH1 PAX5 RUNX1
11 no phenotypic analysis MP:0003012 9.56 CDKN2A CDKN2B ETV6 MTHFR NR3C1 RTN4R
12 skeleton MP:0005390 9.28 ANKS1B CDKN2A MTHFR NOTCH1 NR3C1 PAX5

Drugs & Therapeutics for Acute Lymphocytic Leukemia

FDA approved drugs:

(show all 7)
# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Arranon 18 49 NELARABINE GlaxoSmithKline October 2005
2
Blincyto 18 49 BLINATUMOMAB Amgen December 2014
3
Clolar 18 49 CLOFARABINE Genzyme December, 2004
4
Erwinaze 18 49 asparaginase Erwinia chrysanthemi Eusa Pharma November of 2011
5
Iclusig 18 49 PONATINIB HYDROCHLORIDE Ariad Pharmaceuticals December 2012
6
Marqibo 18 49 VINCRISTINE SULFATE Talon Therapeutics August 2012
7
Sprycel 18 49 DASATINIB Bristol-Myers Squibb June 2006

Drugs for Acute Lymphocytic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 630)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 302-25-0
2
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
3
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 57-22-7, 2068-78-2 5978
4
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 59-05-2, 1959-05-2 126941
5
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
6
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 135968-09-1
7
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2921-57-5
8
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 6055-19-2, 50-18-0 2907
9
Cytarabine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 147-94-4 6253
10
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 174722-31-7 10201696
11
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1177-87-3
12
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-02-2 5743
13
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58957-92-9 42890
14
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-05-9 6006 143
15
Dasatinib Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 302962-49-8 3062316
16
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53-03-2 5865
17
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 20830-81-3 30323
18
Teniposide Approved Phase 4,Phase 3,Phase 2,Not Applicable 29767-20-2 34698
19
Hydrocortisone acetate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-03-3
20
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-23-7 5754
21
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 65271-80-9 4212
22
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 23214-92-8 31703
23
Pegaspargase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 130167-69-0
24
Thioguanine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 154-42-7 2723601
25
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 75607-67-9, 21679-14-1 30751
26
Vindesine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 59917-39-4, 53643-48-4 40839
27
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 33419-42-0 36462
28
Cladribine Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 4291-63-8 20279
29
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 3778-73-2 3690
30
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 22916-47-8 4189
31
Thiotepa Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 52-24-4 5453
32
Busulfan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 55-98-1 2478
33
Epirubicin Approved Phase 4,Phase 3,Phase 2 56420-45-2 41867
34
Micafungin Approved, Investigational Phase 4,Phase 2 235114-32-6 3081921 477468
35
Posaconazole Approved, Investigational, Vet_approved Phase 4,Not Applicable 171228-49-2 147912
36
Methylphenidate Approved, Investigational Phase 4,Not Applicable 113-45-1 4158
37
Dopamine Approved Phase 4,Not Applicable 51-61-6, 62-31-7 681
38
Oprelvekin Approved, Investigational Phase 4 145941-26-0
39
Decitabine Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 2353-33-5 451668
40
Morphine Approved, Investigational Phase 4,Phase 3,Not Applicable 57-27-2 5288826
41
Azacitidine Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 320-67-2 9444
42
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2 1397-89-3 5280965 14956
43
Nicotine Approved Phase 4 54-11-5 942 89594
44
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 59-30-3 6037
45
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 1406-16-2
46
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2 50-14-6 5280793
47
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
48
Prednisolone hemisuccinate Experimental Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2920-86-7
49
Doxil Approved June 1999 Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 31703
50
Treosulfan Investigational Phase 4,Phase 3,Phase 2,Phase 1 299-75-2 9296

Interventional clinical trials:

(show top 50) (show all 1840)
# Name Status NCT ID Phase Drugs
1 German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT00198978 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Cytarabine;Idarubicin;Granulocyte-Colony-Stimulating Factor;Mercaptopurine;Methotrexate;Rituximab;HDARAC;Vincristine;Depocyte;Asparaginase
2 Low-dose Chemotherapy Combine With Tyrosine Kinase Inhibitor to Treat ph+ Acute Lymphoblastic Leukemia Patients Unknown status NCT02690922 Phase 4 Dasatinib;prednisone;dexamethasone;methotrexate
3 Treatment Protocol of Children With Philadelphia Chromosome Negative High Risk Acute Lymphoblastic Leukemia Unknown status NCT01990807 Phase 4 Idarubicin(IDA)
4 The GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia Unknown status NCT00846703 Phase 4 6-mercaptopurine, Methotrexate;6-mercaptopurine, Methotrexate, Vincristine, Dexamethasone
5 Treatment of High Risk Adult Acute Lymphoblastic Leukemia Unknown status NCT00853008 Phase 4 Vincristine;Daunorubicin;Prednisone;Mitoxantrone;Cytosine Arabinoside;Dexamethasone;Methotrexate (MTX);Cytarabine;ASP;Mercaptopurine;Teniposide;Hydrocortisone
6 Medical Research Council (MRC) Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003 Unknown status NCT00222612 Phase 4 Standard childhood UK ALL protocol;Intensified treatment including Capizzi maintenance
7 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (07/2003) Unknown status NCT00198991 Phase 4 Cyclophosphamide;Dexamethasone;Vincristine;daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Prednisolone;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Cladribine
8 Malaysia-Singapore Acute Lymphoblastic Leukemia 2010 Study Unknown status NCT02894645 Phase 4 Prednisolone;Dexamethasone;L-Asparaginase;Vincristine;Methotrexate;Daunorubicin;Doxorubicin;Cyclophosphamide;Cytarabine;6-Mercaptopurine;Thioguanine;Fludarabine;Imatinib
9 Poly(Ethylene Glycol)(PEG)-Asparaginase During Two Treatment Courses Unknown status NCT00192673 Phase 4 PEG-asparaginase
10 HD-Idarubicin/Etoposide Intensified Conditioning Regimen Allo-HSCT for Adult ALL Unknown status NCT01873807 Phase 4 IDA;CTX;VP-16
11 Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults Unknown status NCT00797810 Phase 4 Rituximab
12 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4 Growth Hormone
13 Pulses of Vincristine and Dexamethasone in BFM Protocols for Children With Acute Lymphoblastic Leukemia Completed NCT00411541 Phase 4 vincristine;dexamethasone
14 Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia Completed NCT00199095 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone;Idarubicin;Ifosfamide;Methotrexate;Mercaptopurine;VM26;Vincristine
15 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (06/99) Completed NCT00199056 Phase 4 Dexamethasone / Prednisolone;Cyclophosphamide;Methotrexate;Vincristine / Vindesine;Daunorubicin;Asparaginase;G-CSF;Cytarabine;6-Mercaptopurine;VP16;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Ifosfamide
16 Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia Completed NCT01358253 Phase 4 Cyclophosphamide;Doxorubicin;Vincristine;Dexamethasone;Cytarabine;Methotrexate;Rituximab;6-Mercaptopurine;Prednisone;L-asparaginase
17 LAL-AR-N-2005:Study Treatment for Children High Risk Acute Lymphoblastic Leukemia Completed NCT00526409 Phase 4 Prednisolone;Daunorubicin;Vincristine;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside
18 PETHEMA LAL-RI/96: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Completed NCT00494897 Phase 4 Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin;Mercaptopurine;Prednisone;Vincristine;Methotrexate
19 LAL-Ph-2000: Treatment of Acute Lymphoblastic Leukemia Chromosome Philadelphia Positive Completed NCT00526305 Phase 4 Vincristine;Daunorubicin;Prednisone;L-Asparaginase;Mitoxantrone;Cytosine Arabinoside;Hydrocortisone;Mercaptopurine;Cyclophosphamide;Dexamethasone
20 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93) Completed NCT00199069 Phase 4 Asparaginase;Vincristine;Daunorubicin, Adriamycin;Cyclophosphamide;Ifosfamide;Cytarabine;Mitoxantrone;Methotrexate;6-Mercaptopurine;6-Thioguanine;VM26;Dexamethasone / Prednisolone
21 Trial for Treatment of Adult Patients With Standard Risk Acute Lymphoblastic Leukemia With Chemotherapy and Rituximab Completed NCT00199004 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Vincristine;Daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Adriamycin;Thioguanine;VM26;Rituximab
22 Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome Completed NCT01200355 Phase 4 micafungin;posaconazole
23 ALL-REZ BFM 2002: Multi-Center Study for Children With Relapsed Acute Lymphoblastic Leukemia Completed NCT00114348 Phase 4
24 Learning Impairments Among Survivors of Childhood Cancer Completed NCT00576472 Phase 4 Methylphenidate
25 Effect of rhIL-11 in Patients With Thrombocytopenia for Childhood ALL Completed NCT02314273 Phase 4 rhIL-11
26 LAL-BR/2001: Study Treatment to Low Risk ALL Completed NCT00526175 Phase 4 Prednisone;Vincristine;Daunorubicin;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside;Mercaptopurine;VP-16
27 The Study on the Pharmacokinetics of PEG-rhG-CSF in Children and Adolescents Completed NCT02953730 Phase 4 PEG-rhG-CSF
28 Trial for the Treatment of Newly Diagnosed Mature B-Cell Acute Lymphoblastic Leukemia (B-ALL), Burkitt's Non-Hodgkin's Lymphoma (NHL) and Other High-grade Lymphoma in Adults Completed NCT00199082 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone/Prednisolone;VP16;Ifosfamide;Methotrexate;G-CSF;Rituximab;Vincristine/Vindesine
29 German Multicenter Trial for the Treatment of Newly Diagnosed T-lymphoblastic Lymphoma in Adults Completed NCT00199017 Phase 4 Dexamethasone/Prednisolone;Cyclophosphamide;Vincristine;Daunorubicin;Asparaginase;G-CSF;Mercaptopurine;Cytarabine;Methotrexate;VP16;Vindesine;Adriamycin;Thioguanine;HDARAC;Cladribine
30 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4 cyclophosphamide;thiotepa
31 Nilotinib in Newly Diagnosed Adult Philadelphia Chromosome & /or BCR-ABL Positive Chronic Myeloid Leukaemia in Chronic Phase Completed NCT01061177 Phase 4 Nilotinib
32 Identification of New Immune Factors Specific of Relapse in Childhood B Lineage Acute Lymphoblastic Leukemia Recruiting NCT02618109 Phase 4
33 Protocol For the Treatment Acute Lymphoblastic Leukemia With Ph 'Negative in Elderly Patients (> 55 Years) Recruiting NCT01366898 Phase 4 Dexamethasona, Idarubicine, ARA-C, Methotrexate
34 Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVE Recruiting NCT01491763 Phase 4 Imatinib
35 Study on Two Different Formulations of 6-mercaptopurine. Tablet Versus Oral Liquid Recruiting NCT01906671 Phase 4 Xaluprine;Puri-Nethol
36 PETHEMA LAL-07FRAIL: All Treatment In Fragile Patients Ph' Negative Over 55 Years Recruiting NCT01358201 Phase 4 vINCRISTINE;Dexamethasone;Methotrexate;Cytosine arabinoside
37 ALL SCTped FORUM - Pharmacogenomic Study (add-on Study) Recruiting NCT02670564 Phase 4
38 Pethema LAL-RI/2008: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Recruiting NCT02036489 Phase 4 Vincristine;Daunorubicin;Prednisone;L-asparaginase;Ciclophosphamide;Metotrexate;ARA-C;Hidrocortisone;Mercaptopurine;VP-16;Dexametasone
39 ATG Based Conditioning Regimen in HLA Related HSCT for Aggressive T-cell Tumors Recruiting NCT02938741 Phase 4 Anti-human Thymoglobulin;Placebo
40 G-CSF Alone or Combination With GM-CSF on Prevention and Treatment of Infection in Children With Malignant Tumor Recruiting NCT02933333 Phase 4
41 A Clinical Trial of Decitabine in Relapsed or Refractory T-lymphoblastic Lymphoma Recruiting NCT03558412 Phase 4 Decitabine
42 Vaccinating Children After Chemotherapy Active, not recruiting NCT02447718 Phase 4
43 A Randomized Phase IV Control Trial of Single High Dose Oral Vitamin D3 in Pediatric Patients Undergoing HSCT Enrolling by invitation NCT03176849 Phase 4
44 A Study Of Two Inotuzumab Ozogamicin Doses in Relapsed/ Refractory Acute Lymphoblastic Leukemia Transplant Eligible Patients Not yet recruiting NCT03677596 Phase 4 inotuzumab ozogamicin-dose level 2;Inotuzumab ozogamicin-dose level 1
45 ProphyALL - Study on the Safety of Liposomal Amphotericin B to Prevent Antifungal Infections in Elderly Patients With Acute Lymphoblastic Leukemia Terminated NCT00386997 Phase 4 liposomal amphotericin B (AmBisome®)
46 Atomoxetine for Children With Acquired Attentional Disorders Following Completion of Chemotherapy for ALL Terminated NCT00299234 Phase 4 Atomoxetine
47 Haplo-identical HSCT Versus Chemotherapy for Adult Acute Lymphoblastic Leukemia Patients Unknown status NCT02042690 Phase 3 Chemotherapy
48 Phase III Study of Vincristine Sulfate Liposome For Injection In Adults With Naïve Acute Lymphoblastic Leukemia Unknown status NCT02072785 Phase 3 Vincristine Sulfate Liposome;Vincristine Sulfate
49 Treatment of Acute Lymphoblastic Leukemia or Aggressive Lymphoma With Relapse in Central Nervous System With Depocyt Unknown status NCT00199108 Phase 2, Phase 3 Depocyt;Dexamethasone
50 High-Dose Methotrexate (MTX) for Adult Acute Lymphoblastic Leukemia (ALL) Unknown status NCT00131027 Phase 3 Cyclophosphamide;Daunorubicin;Vincristine;Prednisolone;L-asparaginase;Cytarabine;Etoposide;Dexamethasone;Methotrexate;Mercaptopurine;Doxorubicin;Methotrexate

Search NIH Clinical Center for Acute Lymphocytic Leukemia

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Acute Lymphocytic Leukemia

Anatomical Context for Acute Lymphocytic Leukemia

MalaCards organs/tissues related to Acute Lymphocytic Leukemia:

41
T Cells, B Cells, Bone, Bone Marrow, Myeloid, Testes, Skin

Publications for Acute Lymphocytic Leukemia

Articles related to Acute Lymphocytic Leukemia:

(show top 50) (show all 1921)
# Title Authors Year
1
Insulin-dependent diabetes: A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia. ( 30216644 )
2019
2
Bilateral trifocal IOL implantation in a pediatric case of cataract following steroid-therapy for acute lymphoblastic leukemia. ( 30555958 )
2019
3
Paraneoplastic hypereosinophilic syndrome associated with IL3-IgH positive acute lymphoblastic leukemia. ( 30207070 )
2019
4
TCF7L2 activated HOXA-AS2 decreased the glucocorticoid sensitivity in acute lymphoblastic leukemia through regulating HOXA3/EGFR/Ras/Raf/MEK/ERK pathway. ( 30551418 )
2019
5
The depletion of PHF6 decreases the drug sensitivity of T-cell acute lymphoblastic leukemia to prednisolone. ( 30551478 )
2019
6
In Vitro Cytotoxicity of Folate-Silica-Gold Nanorods on Mouse Acute Lymphoblastic Leukemia and Spermatogonial Cells. ( 30507084 )
2019
7
The rare translocation t(14;21)(q11;q22) detected in a Moroccan patient with T-cell acute lymphoblastic leukemia. ( 30533380 )
2019
8
Efficacy and safety of bispecific T-cell engager (BiTE) antibody blinatumomab for the treatment of relapsed/refractory acute lymphoblastic leukemia and non-Hodgkin's lymphoma: a systemic review and meta-analysis. ( 30479190 )
2019
9
T-Cell Receptor Rearrangements Determined Using Fragment Analysis in Patients With T-Acute Lymphoblastic Leukemia. ( 30430774 )
2019
10
Impairment of Vα24-Jα18+Vβ11+ natural killer T cells in adult acute lymphoblastic leukemia patients. ( 30439366 )
2019
11
DNA methylation and obesity in survivors of pediatric acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study. ( 30382603 )
2019
12
Asparaginase products in upfront acute lymphoblastic leukemia therapy: Value, location, and style. ( 30318846 )
2019
13
Clinical and biological relevance of genetic alterations in pediatric T-cell acute lymphoblastic leukemia in Taiwan. ( 30280491 )
2019
14
Osteonecrosis in children with acute lymphoblastic leukemia: A report from Children's Cancer Hospital Egypt (CCHE). ( 30183135 )
2019
15
Cross-sectional physician survey on the use of minimal residual disease testing in the management of pediatric and adult patients with acute lymphoblastic leukemia. ( 30129384 )
2019
16
Significance of CNS 2 cerebrospinal fluid status post-induction in pediatric and adolescent patients with acute lymphoblastic leukemia. ( 30207055 )
2019
17
A cost-effectiveness analysis of Erwinia asparaginase therapy in children with acute lymphoblastic leukemia. ( 30246496 )
2019
18
Effect of allogeneic blood transfusion on levels of IL-6 and sIL-R2 in peripheral blood of children with acute lymphocytic leukemia. ( 29963154 )
2018
19
Evaluate the Response Rate of Acute Lymphocytic Leukemia Patients to Hyper Cyclophosphamide, Vincristine, Adriamycin, and Dexamethasone Regimen and Remission Rate to Stay Until the End of the Arbitrary Treatment. ( 29930921 )
2018
20
Late effects awareness website for pediatric survivors of acute lymphocytic leukemia. ( 29451924 )
2018
21
50 Years Ago in The Journal of Pediatrics: A Study of "Total Therapy" of Acute Lymphocytic Leukemia in Children. ( 29478493 )
2018
22
Novel mutant of Escherichia coli asparaginase II to reduction of the glutaminase activity in treatment of acute lymphocytic leukemia by molecular dynamics simulations and QM-MM studies. ( 29447943 )
2018
23
Vaccine-associated paralytic poliomyelitis in a patient with acute lymphocytic leukemia. ( 29322435 )
2018
24
Incidence of acute lymphocytic leukemia in Calgary, Alberta, Canada: a retrospective cohort study. ( 29415769 )
2018
25
Up-regulation of HO-1 promotes resistance of B-cell acute lymphocytic leukemia cells to HDAC4/5 inhibitor LMK-235 via the Smad7 pathway. ( 29886060 )
2018
26
Current Allogeneic Hematopoietic Stem Cell Transplantation for Pediatric Acute Lymphocytic Leukemia: Success, Failure and Future Perspectives-A Single-Center Experience, 2008 to 2016. ( 29550628 )
2018
27
Importance of Acute Lymphoblastic Leukemia-type Therapy for Bilineal Acute Leukemia. ( 30198961 )
2018
28
Diagnostic challenges in T-lymphoblastic lymphoma, early T-cell precursor acute lymphoblastic leukemia or mixed phenotype acute leukemia: A case report. ( 30313079 )
2018
29
Hematopoietic stem cell transplantation for adults with Philadelphia chromosome-negative acute lymphoblastic leukemia in first remission: a position statement of the European Working Group for Adult Acute Lymphoblastic Leukemia (EWALL) and the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT). ( 30385870 )
2018
30
Anti-thymocyte globulin improves survival free from relapse and graft-versus-host disease after allogeneic peripheral blood stem cell transplantation in patients with Philadelphia-negative acute lymphoblastic leukemia: An analysis by the Acute Leukemia Working Party of the EBMT. ( 29603136 )
2018
31
Coexistence of T-cell lymphoblastic lymphoma and acute myeloid leukemia mimicking acute lymphocytic leukemia. ( 30004087 )
2018
32
An activating mutation of the NSD2 histone methyltransferase drives oncogenic reprogramming in acute lymphocytic leukemia. ( 30171259 )
2018
33
A successful multidisciplinary approach for treatment and for preserving the reproductive potential in a rare case of acute lymphocytic leukemia during pregnancy. ( 30179055 )
2018
34
Tisagenlecleucel-T for the treatment of acute lymphocytic leukemia. ( 30296188 )
2018
35
Esophageal Varices in Adolescent and Young Adult Males with Acute Lymphocytic Leukemia. ( 30335538 )
2018
36
Disseminated trichosporonosis with atypical histologic findings in a patient with acute lymphocytic leukemia. ( 30468020 )
2018
37
Acute myeloid leukemia with minimal differentiation (AML M0) mimicking acute lymphoblastic leukemia. ( 30431665 )
2018
38
Characteristics of children with acute lymphoblastic leukemia presenting with arthropathy. ( 29464526 )
2018
39
Detection of Disseminated Aspergillosis on FDG PET/CT in a Patient with Acute Lymphoblastic Leukemia. ( 30430806 )
2018
40
A comparative evaluation of dental caries status and salivary properties of children aged 5-14 years undergoing treatment for acute lymphoblastic leukemia, type I diabetes mellitus, and asthma - In vivo. ( 30246751 )
2018
41
Balanitis in Acute Lymphoblastic Leukemia: A Rare Etiology and Unusual Presentation. ( 30127570 )
2018
42
Successful treatment of a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia complicated by bone marrow necrosis and acute renal insufficiency: A case report. ( 30112174 )
2018
43
Case report of neurotoxicity with blinatumomab and concurrent intrathecal chemotherapy in second relapse of acute lymphoblastic leukemia with central nervous system disease. ( 30537919 )
2018
44
Symptomatic Cerebral Sinovenous Thrombosis Associated With L-Asparaginase In Children With Acute Lymphoblastic Leukemia: A Single Institution Experience Over 17 Years. ( 29554021 )
2018
45
Hemorrhagic Cystitis: Treatment With Hyperbaric Oxygen Therapy in Patients With Acute Lymphoblastic Leukemia. ( 30451996 )
2018
46
Verrucous Skin Lesions in a Case of Acute Lymphoblastic Leukemia: A Rare Manifestation of Cytomegalovirus Infection. ( 29622895 )
2018
47
Use of inotuzumab-ozogamicin in a child with Down syndrome and refractory B-cell precursor acute lymphoblastic leukemia. ( 30485640 )
2018
48
Outcome of children and adolescents with Down syndrome treated on Dana-Farber Cancer Institute Acute Lymphoblastic Leukemia Consortium protocols 00-001 and 05-001. ( 29878490 )
2018
49
Acute lymphoblastic leukemia in children with Down syndrome: Comparative analysis versus patients without Down syndrome. ( 30016023 )
2018
50
Weight Gain in Pediatric Acute Lymphoblastic Leukemia Patients With Down Syndrome. ( 29293188 )
2018

Variations for Acute Lymphocytic Leukemia

Expression for Acute Lymphocytic Leukemia

Search GEO for disease gene expression data for Acute Lymphocytic Leukemia.

Pathways for Acute Lymphocytic Leukemia

Pathways related to Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.15 BCR CDKN2A CDKN2B NOTCH1 RUNX1 TP53
2 11.73 ETV6 PAX5 RUNX1 TP53
3 10.3 CDKN2A CDKN2B TP53

GO Terms for Acute Lymphocytic Leukemia

Cellular components related to Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.44 ANKS1B BCR CDKN2A CDKN2B ETV6 MTHFR

Biological processes related to Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.97 CDKN2A NOTCH1 RUNX1 TAL1 TP53
2 transcription by RNA polymerase II GO:0006366 9.8 ETV6 NR3C1 PAX5 RUNX1 TAL1 TP53
3 negative regulation of transcription by RNA polymerase II GO:0000122 9.7 ETV6 NOTCH1 NR3C1 PAX5 RUNX1 TAL1
4 negative regulation of phosphorylation GO:0042326 9.56 CDKN2A CDKN2B
5 cell cycle arrest GO:0007050 9.56 CDKN2A CDKN2B NOTCH1 TP53
6 definitive hemopoiesis GO:0060216 9.55 BCR TAL1
7 hematopoietic stem cell proliferation GO:0071425 9.54 ETV6 RUNX1
8 regulation of B cell receptor signaling pathway GO:0050855 9.52 PAX5 RUNX1
9 regulation of myeloid cell differentiation GO:0045637 9.51 RUNX1 TAL1
10 tetrahydrofolate interconversion GO:0035999 9.49 MTHFR TYMS
11 tetrahydrofolate metabolic process GO:0046653 9.48 MTHFR TYMS
12 somatic stem cell division GO:0048103 9.46 CDKN2A NOTCH1
13 response to folic acid GO:0051593 9.43 MTHFR TYMS
14 megakaryocyte differentiation GO:0030219 9.4 CDKN2B TAL1
15 obsolete negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031658 9.37 CDKN2A CDKN2B
16 positive regulation of transcription by RNA polymerase II GO:0045944 9.28 CDKN2A CDKN2B ETV6 NOTCH1 NR3C1 PAX5
17 replicative senescence GO:0090399 9.13 CDKN2A MME TP53

Molecular functions related to Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.56 ETV6 RUNX1 TAL1 TAL2
2 DNA-binding transcription factor activity GO:0003700 9.5 ETV6 NOTCH1 NR3C1 PAX5 RUNX1 TAL1
3 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.17 ETV6 NOTCH1 NR3C1 PAX5 RUNX1 TAL1
4 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 9.16 CDKN2A CDKN2B

Sources for Acute Lymphocytic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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