MCID: ACT074
MIFTS: 59

Acute Lymphocytic Leukemia

Categories: Cancer diseases, Immune diseases, Blood diseases, Rare diseases

Aliases & Classifications for Acute Lymphocytic Leukemia

MalaCards integrated aliases for Acute Lymphocytic Leukemia:

Name: Acute Lymphocytic Leukemia 38 12 76 43 15 73
Precursor Cell Lymphoblastic Leukemia Lymphoma 73
Acute Lymphoblastic Leukemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9952
ICD10 33 C91.0 C91.00
ICD9CM 35 204.0
NCIt 50 C3167

Summaries for Acute Lymphocytic Leukemia

MedlinePlus : 43 Leukemia is cancer of the white blood cells. White blood cells help your body fight infection. Your blood cells form in your bone marrow. In leukemia, however, the bone marrow produces abnormal white blood cells. These cells crowd out the healthy blood cells, making it hard for blood to do its work. In acute lymphocytic leukemia (ALL), also called acute lymphoblastic leukemia, there are too many of specific types of white blood cells called lymphocytes or lymphoblasts. ALL is the most common type of cancer in children. Possible risk factors for ALL include being male, being white, previous chemotherapy treatment, exposure to radiation, and for adults, being older than 70. Symptoms of ALL include: Weakness or feeling tired Fever Easy bruising or bleeding Bleeding under the skin Shortness of breath Weight loss or loss of appetite Pain in the bones or stomach Pain or a feeling of fullness below the ribs Painless lumps in the neck, underarm, stomach, or groin Tests that examine the blood and bone marrow diagnose ALL. Treatments include chemotherapy, radiation therapy, stem cell transplants, and targeted therapy. Targeted therapy uses substances that attack cancer cells without harming normal cells. Once the leukemia is in remission, you need additional treatment to make sure that it does not come back. NIH: National Cancer Institute

MalaCards based summary : Acute Lymphocytic Leukemia, also known as precursor cell lymphoblastic leukemia lymphoma, is related to acute lymphoblastic leukemia, childhood and leukemia, acute lymphoblastic, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Acute Lymphocytic Leukemia is RTN4R (Reticulon 4 Receptor
Lnc-RTN4R-1 and lnc-NKX2-3-1 as lncRNAs that might be functionally implicated in the biology of this prevalent subtype of human leukemia.
Dysfunction Pattern: ), and among its related pathways/superpathways are Pathways in cancer and Transcriptional misregulation in cancer. The drugs Arranon and Blincyto have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone and bone marrow, and related phenotypes are homeostasis/metabolism and growth/size/body region

Disease Ontology : 12 A lymphoblastic leukemia that is characterized by over production of lymphoblasts.

Wikipedia : 76 Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the... more...

Related Diseases for Acute Lymphocytic Leukemia

Diseases in the Acute Lymphocytic Leukemia family:

Leukemia, Chronic Lymphocytic 2 Leukemia, Chronic Lymphocytic
Leukemia, Chronic Lymphocytic 1 Leukemia, Chronic Lymphocytic 3
Leukemia, Chronic Lymphocytic 4 Leukemia, Chronic Lymphocytic 5
Adult Acute Lymphocytic Leukemia

Diseases related to Acute Lymphocytic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 203)
# Related Disease Score Top Affiliating Genes
1 acute lymphoblastic leukemia, childhood 32.9 CDKN2A CDKN2B ETV6 MME MTHFR RUNX1
2 leukemia, acute lymphoblastic 32.9 BCR ETV6 MME PAX5 RUNX1 TPMT
3 childhood leukemia 32.7 ETV6 MTHFR RUNX1 TP53
4 acute leukemia 32.6 ETV6 MTHFR PAX5 RUNX1 TAL1
5 precursor t-cell acute lymphoblastic leukemia 32.0 BCR CDKN2A CDKN2B ETV6 NOTCH1 TAL1
6 leukemia, acute lymphoblastic 3 31.3 BCR CDKN2A CDKN2B ETV6 MME PAX5
7 lymphoblastic leukemia 31.3 BCR CDKN2A ETV6 NOTCH1 PAX5 RUNX1
8 leukemia 31.1 BCR CDKN2B-AS1 ETV6 NOTCH1 RUNX1 TAL1
9 central nervous system leukemia 31.0 MME RUNX1
10 lymphoblastic lymphoma 30.8 CDKN2B MME NOTCH1 TAL1
11 myeloid leukemia 30.5 BCR ETV6 RUNX1 TP53
12 leukemia, chronic myeloid 30.2 BCR CDKN2B ETV6 RUNX1
13 lymphoma, non-hodgkin, familial 29.9 BCR CDKN2B MME PAX5 TP53
14 leukemia, acute myeloid 29.0 BCR CDKN2B CDKN2B-AS1 ETV6 MME RUNX1
15 adult acute lymphocytic leukemia 12.4
16 b-cell adult acute lymphocytic leukemia 12.2
17 t-cell adult acute lymphocytic leukemia 12.2
18 t-cell childhood acute lymphocytic leukemia 12.1
19 ataxia-telangiectasia 11.1
20 fallopian tube endometrioid adenocarcinoma 11.0 CDKN2A MME
21 platelet disorder, familial, with associated myeloid malignancy 10.9 ETV6 RUNX1
22 b-cell childhood acute lymphoblastic leukemia 10.9 ETV6 RUNX1
23 splenic diffuse red pulp small b-cell lymphoma 10.9 NOTCH1 TP53
24 brain stem astrocytic neoplasm 10.9 CDKN2A TP53
25 tetraploidy 10.8 NOTCH1 TP53
26 invasive bladder transitional cell carcinoma 10.8 NOTCH1 TP53
27 tenosynovial giant cell tumor 10.8 CDKN2A CDKN2B
28 malignant leydig cell tumor 10.8 MME PAX5
29 keratinizing squamous cell carcinoma 10.8 CDKN2A TP53
30 spitz nevus 10.7 CDKN2A TP53
31 cll/sll 10.7 MME PAX5 TP53
32 bone squamous cell carcinoma 10.7 CDKN2A NOTCH1 TP53
33 schneiderian carcinoma 10.7 CDKN2A NOTCH1 TP53
34 thyroid lymphoma 10.7 CDKN2A CDKN2B TP53
35 peripheral t-cell lymphoma 10.7 ETV6 MME TP53
36 scrotal carcinoma 10.7 CDKN2A CDKN2B TP53
37 gastrointestinal system benign neoplasm 10.7 CDKN2A MTHFR TP53
38 bladder carcinoma in situ 10.7 CDKN2A TP53
39 grade iii astrocytoma 10.7 CDKN2A CDKN2B TP53
40 melanoma, cutaneous malignant 1 10.6 CDKN2A CDKN2B TP53
41 nodular regenerative hyperplasia 10.6 NOTCH1 TPMT
42 bartholin's gland benign neoplasm 10.6 CDKN2A TP53
43 oligodendroglioma 10.6 CDKN2A CDKN2B TP53
44 vulva squamous cell carcinoma 10.6 CDKN2A TP53
45 bladder lymphoma 10.5 MME PAX5
46 pancreas adenocarcinoma 10.5 CDKN2A NOTCH1 TP53
47 in situ carcinoma 10.5 CDKN2A NR3C1 TP53
48 melanoma-pancreatic cancer syndrome 10.5 CDKN2A CDKN2B-AS1
49 mantle cell lymphoma 10.5 CDKN2A MME PAX5 TP53
50 b-cell lymphomas 10.5 CDKN2A MME PAX5 TP53

Graphical network of the top 20 diseases related to Acute Lymphocytic Leukemia:



Diseases related to Acute Lymphocytic Leukemia

Symptoms & Phenotypes for Acute Lymphocytic Leukemia

UMLS symptoms related to Acute Lymphocytic Leukemia:


angina pectoris, chest pain, edema

MGI Mouse Phenotypes related to Acute Lymphocytic Leukemia:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.36 TPMT ANKS1B BCR CDKN2A CDKN2B ETV6
2 growth/size/body region MP:0005378 10.27 TAL1 TAL2 TP53 TPMT BCR CDKN2A
3 cellular MP:0005384 10.26 BCR CDKN2A CDKN2B ETV6 NOTCH1 NR3C1
4 hematopoietic system MP:0005397 10.26 BCR CDKN2A CDKN2B ETV6 NOTCH1 NR3C1
5 behavior/neurological MP:0005386 10.24 ANKS1B BCR CDKN2A NR3C1 PAX5 RTN4R
6 immune system MP:0005387 10.21 BCR CDKN2A CDKN2B ETV6 MME NOTCH1
7 mortality/aging MP:0010768 10.2 ANKS1B BCR CDKN2A CDKN2B ETV6 MTHFR
8 integument MP:0010771 10.14 CDKN2A CDKN2B ETV6 MME MTHFR NOTCH1
9 digestive/alimentary MP:0005381 10.05 BCR CDKN2A ETV6 NOTCH1 NR3C1 TLX3
10 nervous system MP:0003631 9.97 CDKN2A MTHFR NOTCH1 NR3C1 PAX5 RTN4R
11 liver/biliary system MP:0005370 9.91 CDKN2A MME NOTCH1 NR3C1 RUNX1 TP53
12 neoplasm MP:0002006 9.86 CDKN2A CDKN2B ETV6 NOTCH1 PAX5 RUNX1
13 no phenotypic analysis MP:0003012 9.56 CDKN2A CDKN2B ETV6 MTHFR NR3C1 RTN4R
14 skeleton MP:0005390 9.28 ANKS1B CDKN2A MTHFR NOTCH1 NR3C1 PAX5

Drugs & Therapeutics for Acute Lymphocytic Leukemia

FDA approved drugs:

(show all 7)
# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Arranon 18 49 NELARABINE GlaxoSmithKline October 2005
2
Blincyto 18 49 BLINATUMOMAB Amgen December 2014
3
Clolar 18 49 CLOFARABINE Genzyme December, 2004
4
Erwinaze 18 49 asparaginase Erwinia chrysanthemi Eusa Pharma November of 2011
5
Iclusig 18 49 PONATINIB HYDROCHLORIDE Ariad Pharmaceuticals December 2012
6
Marqibo 18 49 VINCRISTINE SULFATE Talon Therapeutics August 2012
7
Sprycel 18 49 DASATINIB Bristol-Myers Squibb June 2006

Drugs for Acute Lymphocytic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 619)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-18-0, 6055-19-2 2907
2
Cytarabine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 147-94-4 6253
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 50-02-2 5743
4
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58957-92-9 42890
5
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 135968-09-1
6
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1959-05-2, 59-05-2 126941
7
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
8
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
9
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 174722-31-7 10201696
10
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 2068-78-2, 57-22-7 5978
11
Dasatinib Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 302962-49-8 3062316
12
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53-03-2 5865
13
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 20830-81-3 30323
14
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 23214-92-8 31703
15
Pegaspargase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 130167-69-0
16
Cladribine Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 4291-63-8 20279
17
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 33419-42-0 36462
18
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 21679-14-1, 75607-67-9 30751
19
Teniposide Approved Phase 4,Phase 3,Phase 2,Not Applicable 29767-20-2 34698
20
Thioguanine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 154-42-7 2723601
21
Vindesine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 59917-39-4, 53643-48-4 40839
22
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 3778-73-2 3690
23
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-23-7 5754
24
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 65271-80-9 4212
25
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 22916-47-8 4189
26
Thiotepa Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 52-24-4 5453
27
Busulfan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 55-98-1 2478
28
Micafungin Approved, Investigational Phase 4,Phase 2 235114-32-6 3081921 477468
29
Posaconazole Approved, Investigational, Vet_approved Phase 4,Not Applicable 171228-49-2 147912
30
Dopamine Approved Phase 4,Not Applicable 51-61-6, 62-31-7 681
31
Methylphenidate Approved, Investigational Phase 4,Not Applicable 113-45-1 4158
32
Oprelvekin Approved, Investigational Phase 4 145941-26-0
33
Menthol Approved Phase 4,Not Applicable 2216-51-5 16666
34
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2 1397-89-3 14956 5280965
35
Nicotine Approved Phase 4 54-11-5 942 89594
36
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 59-30-3 6037
37
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-05-9 143 6006
38
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2 50-14-6 5280793
39
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 1406-16-2
40
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 6221 5280795
41
Doxil Approved June 1999 Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 31703
42
Butyric Acid Experimental, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 107-92-6 264
43
Treosulfan Investigational Phase 4,Phase 3,Phase 2,Phase 1 299-75-2 9296
44
Lactitol Investigational Phase 4,Phase 2,Phase 1 585-86-4 3871
45 6-Mercaptopurine Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
46 Adjuvants, Immunologic Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
47 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
48 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
49 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
50 Antiemetics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 1771)
# Name Status NCT ID Phase Drugs
1 German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT00198978 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Cytarabine;Idarubicin;Granulocyte-Colony-Stimulating Factor;Mercaptopurine;Methotrexate;Rituximab;HDARAC;Vincristine;Depocyte;Asparaginase
2 Low-dose Chemotherapy Combine With Tyrosine Kinase Inhibitor to Treat ph+ Acute Lymphoblastic Leukemia Patients Unknown status NCT02690922 Phase 4 Dasatinib;prednisone;dexamethasone;methotrexate
3 Treatment Protocol of Children With Philadelphia Chromosome Negative High Risk Acute Lymphoblastic Leukemia Unknown status NCT01990807 Phase 4 Idarubicin(IDA)
4 Medical Research Council (MRC) Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003 Unknown status NCT00222612 Phase 4 Standard childhood UK ALL protocol;Intensified treatment including Capizzi maintenance
5 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (07/2003) Unknown status NCT00198991 Phase 4 Cyclophosphamide;Dexamethasone;Vincristine;daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Prednisolone;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Cladribine
6 Poly(Ethylene Glycol)(PEG)-Asparaginase During Two Treatment Courses Unknown status NCT00192673 Phase 4 PEG-asparaginase
7 HD-Idarubicin/Etoposide Intensified Conditioning Regimen Allo-HSCT for Adult ALL Unknown status NCT01873807 Phase 4 IDA;CTX;VP-16
8 Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults Unknown status NCT00797810 Phase 4 Rituximab
9 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4 Growth Hormone
10 Pulses of Vincristine and Dexamethasone in BFM Protocols for Children With Acute Lymphoblastic Leukemia Completed NCT00411541 Phase 4 vincristine;dexamethasone
11 Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia Completed NCT00199095 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone;Idarubicin;Ifosfamide;Methotrexate;Mercaptopurine;VM26;Vincristine
12 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (06/99) Completed NCT00199056 Phase 4 Dexamethasone / Prednisolone;Cyclophosphamide;Methotrexate;Vincristine / Vindesine;Daunorubicin;Asparaginase;G-CSF;Cytarabine;6-Mercaptopurine;VP16;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Ifosfamide
13 Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia Completed NCT01358253 Phase 4 Cyclophosphamide;Doxorubicin;Vincristine;Dexamethasone;Cytarabine;Methotrexate;Rituximab;6-Mercaptopurine;Prednisone;L-asparaginase
14 LAL-AR-N-2005:Study Treatment for Children High Risk Acute Lymphoblastic Leukemia Completed NCT00526409 Phase 4 Prednisolone;Daunorubicin;Vincristine;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside
15 PETHEMA LAL-RI/96: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Completed NCT00494897 Phase 4 Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin;Mercaptopurine;Prednisone;Vincristine;Methotrexate
16 LAL-Ph-2000: Treatment of Acute Lymphoblastic Leukemia Chromosome Philadelphia Positive Completed NCT00526305 Phase 4 Vincristine;Daunorubicin;Prednisone;L-Asparaginase;Mitoxantrone;Cytosine Arabinoside;Hydrocortisone;Mercaptopurine;Cyclophosphamide;Dexamethasone
17 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93) Completed NCT00199069 Phase 4 Asparaginase;Vincristine;Daunorubicin, Adriamycin;Cyclophosphamide;Ifosfamide;Cytarabine;Mitoxantrone;Methotrexate;6-Mercaptopurine;6-Thioguanine;VM26;Dexamethasone / Prednisolone
18 Trial for Treatment of Adult Patients With Standard Risk Acute Lymphoblastic Leukemia With Chemotherapy and Rituximab Completed NCT00199004 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Vincristine;Daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Adriamycin;Thioguanine;VM26;Rituximab
19 Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome Completed NCT01200355 Phase 4 micafungin;posaconazole
20 ALL-REZ BFM 2002: Multi-Center Study for Children With Relapsed Acute Lymphoblastic Leukemia Completed NCT00114348 Phase 4
21 Learning Impairments Among Survivors of Childhood Cancer Completed NCT00576472 Phase 4 Methylphenidate
22 Effect of rhIL-11 in Patients With Thrombocytopenia for Childhood ALL Completed NCT02314273 Phase 4 rhIL-11
23 LAL-BR/2001: Study Treatment to Low Risk ALL Completed NCT00526175 Phase 4 Prednisone;Vincristine;Daunorubicin;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside;Mercaptopurine;VP-16
24 The Study on the Pharmacokinetics of PEG-rhG-CSF in Children and Adolescents Completed NCT02953730 Phase 4 PEG-rhG-CSF
25 Trial for the Treatment of Newly Diagnosed Mature B-Cell Acute Lymphoblastic Leukemia (B-ALL), Burkitt's Non-Hodgkin's Lymphoma (NHL) and Other High-grade Lymphoma in Adults Completed NCT00199082 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone/Prednisolone;VP16;Ifosfamide;Methotrexate;G-CSF;Rituximab;Vincristine/Vindesine
26 German Multicenter Trial for the Treatment of Newly Diagnosed T-lymphoblastic Lymphoma in Adults Completed NCT00199017 Phase 4 Dexamethasone/Prednisolone;Cyclophosphamide;Vincristine;Daunorubicin;Asparaginase;G-CSF;Mercaptopurine;Cytarabine;Methotrexate;VP16;Vindesine;Adriamycin;Thioguanine;HDARAC;Cladribine
27 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4 cyclophosphamide;thiotepa
28 Nilotinib in Newly Diagnosed Adult Philadelphia Chromosome & /or BCR-ABL Positive Chronic Myeloid Leukaemia in Chronic Phase Completed NCT01061177 Phase 4 Nilotinib
29 Identification of New Immune Factors Specific of Relapse in Childhood B Lineage Acute Lymphoblastic Leukemia Recruiting NCT02618109 Phase 4
30 Protocol For the Treatment Acute Lymphoblastic Leukemia With Ph 'Negative in Elderly Patients (> 55 Years) Recruiting NCT01366898 Phase 4 Dexamethasona, Idarubicine, ARA-C, Methotrexate
31 The GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia Recruiting NCT00846703 Phase 4 6-mercaptopurine, Methotrexate;6-mercaptopurine, Methotrexate, Vincristine, Dexamethasone
32 Malaysia-Singapore Acute Lymphoblastic Leukemia 2010 Study Recruiting NCT02894645 Phase 4 Prednisolone;Dexamethasone;L-Asparaginase;Vincristine;Methotrexate;Daunorubicin;Doxorubicin;Cyclophosphamide;Cytarabine;6-Mercaptopurine;Thioguanine;Fludarabine;Imatinib
33 Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVE Recruiting NCT01491763 Phase 4 Imatinib
34 Study on Two Different Formulations of 6-mercaptopurine. Tablet Versus Oral Liquid Recruiting NCT01906671 Phase 4 Xaluprine;Puri-Nethol
35 PETHEMA LAL-07FRAIL: All Treatment In Fragile Patients Ph' Negative Over 55 Years Recruiting NCT01358201 Phase 4 vINCRISTINE;Dexamethasone;Methotrexate;Cytosine arabinoside
36 Vaccinating Children After Chemotherapy Recruiting NCT02447718 Phase 4
37 ALL SCTped FORUM - Pharmacogenomic Study (add-on Study) Recruiting NCT02670564 Phase 4
38 Pethema LAL-RI/2008: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Recruiting NCT02036489 Phase 4 Vincristine;Daunorubicin;Prednisone;L-asparaginase;Ciclophosphamide;Metotrexate;ARA-C;Hidrocortisone;Mercaptopurine;VP-16;Dexametasone
39 ATG Based Conditioning Regimen in HLA Related HSCT for Aggressive T-cell Tumors Recruiting NCT02938741 Phase 4 Anti-human Thymoglobulin;Placebo
40 A Clinical Trial of Decitabine in Relapse and Refractory T-lymphoblastic Lymphoma Recruiting NCT03558412 Phase 4 Decitabine
41 Treatment of High Risk Adult Acute Lymphoblastic Leukemia Active, not recruiting NCT00853008 Phase 4 Vincristine;Daunorubicin;Prednisone;Mitoxantrone;Cytosine Arabinoside;Dexamethasone;Methotrexate (MTX);Cytarabine;ASP;Mercaptopurine;Teniposide;Hydrocortisone
42 G-CSF Alone or Combination With GM-CSF on Prevention and Treatment of Infection in Children With Malignant Tumor Not yet recruiting NCT02933333 Phase 4
43 A Randomized Phase IV Control Trial of Single High Dose Oral Vitamin D3 in Pediatric Patients Undergoing HSCT Not yet recruiting NCT03176849 Phase 4
44 ProphyALL - Study on the Safety of Liposomal Amphotericin B to Prevent Antifungal Infections in Elderly Patients With Acute Lymphoblastic Leukemia Terminated NCT00386997 Phase 4 liposomal amphotericin B (AmBisome®)
45 Atomoxetine for Children With Acquired Attentional Disorders Following Completion of Chemotherapy for ALL Terminated NCT00299234 Phase 4 Atomoxetine
46 Phase III Study of Vincristine Sulfate Liposome For Injection In Adults With Naïve Acute Lymphoblastic Leukemia Unknown status NCT02072785 Phase 3 Vincristine Sulfate Liposome;Vincristine Sulfate
47 Treatment of Acute Lymphoblastic Leukemia or Aggressive Lymphoma With Relapse in Central Nervous System With Depocyt Unknown status NCT00199108 Phase 2, Phase 3 Depocyt;Dexamethasone
48 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT00103285 Phase 3 doxorubicin hydrochloride;cytarabine;dexamethasone;pegaspargase;methotrexate;leucovorin calcium;mercaptopurine;cyclophosphamide;thioguanine;vincristine sulfate
49 High-Dose Methotrexate (MTX) for Adult Acute Lymphoblastic Leukemia (ALL) Unknown status NCT00131027 Phase 3 Cyclophosphamide;Daunorubicin;Vincristine;Prednisolone;L-asparaginase;Cytarabine;Etoposide;Dexamethasone;Methotrexate;Mercaptopurine;Doxorubicin;Methotrexate
50 Hormone Therapy Plus Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia Unknown status NCT00003437 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;pegaspargase;prednisolone;thioguanine;vincristine sulfate

Search NIH Clinical Center for Acute Lymphocytic Leukemia

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Acute Lymphocytic Leukemia

Anatomical Context for Acute Lymphocytic Leukemia

MalaCards organs/tissues related to Acute Lymphocytic Leukemia:

41
T Cells, Bone, Bone Marrow, B Cells, Myeloid, Testes, Kidney

Publications for Acute Lymphocytic Leukemia

Articles related to Acute Lymphocytic Leukemia:

(show top 50) (show all 632)
# Title Authors Year
1
Effect of allogeneic blood transfusion on levels of IL-6 and sIL-R2 in peripheral blood of children with acute lymphocytic leukemia. ( 29963154 )
2018
2
Evaluate the Response Rate of Acute Lymphocytic Leukemia Patients to Hyper Cyclophosphamide, Vincristine, Adriamycin, and Dexamethasone Regimen and Remission Rate to Stay Until the End of the Arbitrary Treatment. ( 29930921 )
2018
3
Late effects awareness website for pediatric survivors of acute lymphocytic leukemia. ( 29451924 )
2018
4
50 Years Ago in The Journal of Pediatrics: A Study of "Total Therapy" of Acute Lymphocytic Leukemia in Children. ( 29478493 )
2018
5
Novel mutant of Escherichia coli asparaginase II to reduction of the glutaminase activity in treatment of acute lymphocytic leukemia by molecular dynamics simulations and QM-MM studies. ( 29447943 )
2018
6
Vaccine-associated paralytic poliomyelitis in a patient with acute lymphocytic leukemia. ( 29322435 )
2018
7
Incidence of acute lymphocytic leukemia in Calgary, Alberta, Canada: a retrospective cohort study. ( 29415769 )
2018
8
Up-regulation of HO-1 promotes resistance of B-cell acute lymphocytic leukemia cells to HDAC4/5 inhibitor LMK-235 via the Smad7 pathway. ( 29886060 )
2018
9
Current Allogeneic Hematopoietic Stem Cell Transplantation for Pediatric Acute Lymphocytic Leukemia: Success, Failure and Future Perspectives-A Single-Center Experience, 2008 to 2016. ( 29550628 )
2018
10
Inotuzumab ozogamicin for the treatment of patients with acute lymphocytic leukemia. ( 29517084 )
2017
11
TS Gene Polymorphisms Correlate with Susceptibility to Acute Lymphocytic Leukemia in Children. ( 28646637 )
2017
12
Diagnosis of Lymphoid Malignancy by PCR for Analysis of Antigen Receptor Rearrangement after Blood Transfusion in a Dog with Acute Lymphocytic Leukemia. ( 28860956 )
2017
13
Magnusiomyces capitatus Peritonitis in a Child With Acute Lymphocytic Leukemia as a Breakthrough Infection During Caspofungin Therapy. ( 29145348 )
2017
14
Blinatumomab (Blincyto): lessons learned from the bispecific t-cell engager (BiTE) in acute lymphocytic leukemia (ALL). ( 28379283 )
2017
15
Treatment of Philadelphia Chromosome-Positive Acute Lymphocytic Leukemia. ( 28382538 )
2017
16
ASSESSMENT OF THE LATE EFFECTS ON BONES AND ON BODY COMPOSITION OF CHILDREN AND ADOLESCENTS TREATED FOR ACUTE LYMPHOCYTIC LEUKEMIA ACCORDING TO BRAZILIAN PROTOCOLS. ( 28977305 )
2017
17
Bitterness in sugar: O-GlcNAcylation aggravates pre-B acute lymphocytic leukemia through glycolysis via the PI3K/Akt/c-Myc pathway. ( 28670495 )
2017
18
Hyper-CVAD + epratuzumab as a salvage regimen for younger patients with relapsed/refractory CD22-positive precursor B-cell acute lymphocytic leukemia. ( 28154086 )
2017
19
The correlation between Pax5 deletion and patients survival in Iranian children with precursor B-cell acute lymphocytic leukemia. ( 28886309 )
2017
20
New Therapeutic Strategies in Acute Lymphocytic Leukemia. ( 28353016 )
2017
21
Minimal contribution of severe hypertriglyceridemia in L-asparaginase-associated pancreatitis developed in a child with acute lymphocytic leukemia. ( 27599414 )
2016
22
Novel Approaches for the Interim Management of Relapsed/Refractory Acute Lymphocytic Leukemia: Introduction. ( 27007406 )
2016
23
Myelodysplastic Syndrome and Acute Lymphocytic Leukemia in Common Variable Immunodeficiency (CVID). ( 26993985 )
2016
24
Secondary glioma following acute lymphocytic leukemia: therapeutic implications. ( 27159974 )
2016
25
Effect of the Polymorphism of Folylpolyglutamate Synthetase on Treatment of High-Dose Methotrexate in Pediatric Patients with Acute Lymphocytic Leukemia. ( 27987364 )
2016
26
Palifermin and Chlorhexidine Mouthwashes in Prevention of Chemotherapy-Induced Mucositis in Children with Acute Lymphocytic Leukemia: a Randomized Controlled Trial. ( 27942550 )
2016
27
A single black ulcer in a child with acute lymphocytic leukemia. ( 28099607 )
2016
28
Catheter-related bloodstream infection due to Gordonia sputi in a patient with acute lymphocytic leukemia: a Case Report. ( 26902218 )
2016
29
Acute lymphocytic leukemia presenting as a single brain mass. ( 27430416 )
2016
30
Health-Related Quality of Life, Depression, Anxiety, and Self-Image in Acute Lymphocytic Leukemia Survivors. ( 27094799 )
2016
31
Disseminated Mycobacterium abscessus Complex Infection Manifesting as Multiple Areas of Lymphadenitis and Skin Abscess in the Preclinical Stage of Acute Lymphocytic Leukemia. ( 27374685 )
2016
32
Treating adults with acute lymphocytic leukemia: new pharmacotherapy options. ( 27759440 )
2016
33
Campylobacter jejuni Bacteremia in a Patient With Acute Lymphocytic Leukemia. ( 27621914 )
2016
34
Acute lymphocytic leukemia mimicking spondyloarthritis in an adolescent: A case report and review of the literature. ( 26893708 )
2016
35
Air toxics and early childhood acute lymphocytic leukemia in Texas, a population based case control study. ( 27301866 )
2016
36
Role of peripheral blood minimum residual disease at day 8 of induction therapy in high-risk pediatric patients with acute lymphocytic leukemia. ( 27526794 )
2016
37
B Cell Acute Lymphocytic Leukemia Presenting as a Bile Duct Stricture Diagnosed With Cholangioscopy. ( 27807569 )
2016
38
Efficacy and Safety of Vincristine Sulfate Liposome Injection in the Treatment of Adult Acute Lymphocytic Leukemia. ( 27328933 )
2016
39
Recent advances and novel treatment paradigms in acute lymphocytic leukemia. ( 27695616 )
2016
40
Recurrence of acute lymphocytic leukemia as spinal epidural mass. ( 26778825 )
2016
41
Extramedullary Involvement of the Sigmoid Colon with Acute Lymphocytic Leukemia. ( 27189376 )
2016
42
Multiple unusual lung etiologies in a child with acute lymphocytic leukemia. ( 27616461 )
2016
43
Allogeneic bone marrow transplantation for therapy-related acute lymphocytic leukemia after autologous hematopoietic stem cell transplantation for multiple myeloma. ( 27473192 )
2016
44
Blinatumomab: A New Treatment for Adults With Relapsed Acute Lymphocytic Leukemia. ( 26991709 )
2016
45
Expression of CD56 is a risk factor for acute lymphocytic leukemia with central nervous system involvement in adults. ( 27734763 )
2016
46
Potent anti-leukemia activities of chimeric antigen receptor modified T cells against CD19 in Chinese patients with relapsed/refractory acute lymphocytic leukemia. ( 28039267 )
2016
47
Immunization practices in acute lymphocytic leukemia and post-hematopoietic stem cell transplant in Canadian Pediatric Hematology/Oncology centers. ( 26962702 )
2016
48
BIRC3 alterations in chronic and B-cell acute lymphocytic leukemia patients. ( 27123097 )
2016
49
Successful Pregnancy and Delivery After Radiation With Ovarian Shielding for Acute Lymphocytic Leukemia Before Menarche. ( 25739028 )
2015
50
Tetramethylpyrazine inhibits the proliferation of acute lymphocytic leukemia cell lines via decrease in GSK-3I^. ( 25812605 )
2015

Variations for Acute Lymphocytic Leukemia

Expression for Acute Lymphocytic Leukemia

Search GEO for disease gene expression data for Acute Lymphocytic Leukemia.

Pathways for Acute Lymphocytic Leukemia

Pathways related to Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.35 BCR CDKN2A CDKN2B NOTCH1 RUNX1 TP53
2 11.29 ETV6 PAX5 RUNX1 TLX3 TP53
3 10.64 CDKN2A CDKN2B TP53

GO Terms for Acute Lymphocytic Leukemia

Cellular components related to Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.4 ANKS1B BCR CDKN2A CDKN2B ETV6 MTHFR

Biological processes related to Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 transcription by RNA polymerase II GO:0006366 9.97 ETV6 NR3C1 PAX5 RUNX1 TP53
2 positive regulation of transcription, DNA-templated GO:0045893 9.95 CDKN2A NOTCH1 RUNX1 TAL1 TP53
3 negative regulation of transcription by RNA polymerase II GO:0000122 9.91 ETV6 NOTCH1 NR3C1 PAX5 TAL1 TP53
4 negative regulation of phosphorylation GO:0042326 9.56 CDKN2A CDKN2B
5 neuron differentiation GO:0030182 9.56 NOTCH1 RUNX1 TAL1 TLX3
6 definitive hemopoiesis GO:0060216 9.54 BCR TAL1
7 hematopoietic stem cell proliferation GO:0071425 9.52 ETV6 RUNX1
8 regulation of myeloid cell differentiation GO:0045637 9.49 RUNX1 TAL1
9 somatic stem cell division GO:0048103 9.48 CDKN2A NOTCH1
10 regulation of B cell receptor signaling pathway GO:0050855 9.46 PAX5 RUNX1
11 cell cycle arrest GO:0007050 9.46 CDKN2A CDKN2B NOTCH1 TP53
12 negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031658 9.4 CDKN2A CDKN2B
13 megakaryocyte differentiation GO:0030219 9.37 CDKN2B TAL1
14 positive regulation of transcription by RNA polymerase II GO:0045944 9.28 CDKN2A CDKN2B ETV6 NOTCH1 NR3C1 PAX5
15 replicative senescence GO:0090399 9.13 CDKN2A MME TP53
16 transcription, DNA-templated GO:0006351 10.16 CDKN2A ETV6 NOTCH1 NR3C1 PAX5 RUNX1
17 regulation of transcription, DNA-templated GO:0006355 10.02 CDKN2A ETV6 NOTCH1 NR3C1 PAX5 RUNX1

Molecular functions related to Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.97 CDKN2A ETV6 NR3C1 PAX5 RUNX1 TAL1
2 DNA binding transcription factor activity GO:0003700 9.8 ETV6 NOTCH1 NR3C1 PAX5 RUNX1 TAL1
3 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.71 ETV6 RUNX1 TAL1 TAL2
4 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000981 9.56 ETV6 NR3C1 PAX5 RUNX1 TAL1 TAL2
5 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 9.37 CDKN2A CDKN2B
6 core promoter binding GO:0001047 9.33 NOTCH1 NR3C1 RUNX1
7 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.02 ETV6 NR3C1 PAX5 TAL1 TP53

Sources for Acute Lymphocytic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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