MCID: ACT165
MIFTS: 14

Acute Megakaryoblastic Leukemia Without Down Syndrome

Categories: Blood diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Acute Megakaryoblastic Leukemia Without Down Syndrome

MalaCards integrated aliases for Acute Megakaryoblastic Leukemia Without Down Syndrome:

Name: Acute Megakaryoblastic Leukemia Without Down Syndrome 58
Non-Ds-Amkl 58

Characteristics:

Orphanet epidemiological data:

58
acute megakaryoblastic leukemia without down syndrome
Inheritance: Not applicable; Age of onset: Childhood;

Classifications:

Orphanet: 58  
Rare haematological diseases


External Ids:

ICD10 via Orphanet 33 C94.2
Orphanet 58 ORPHA329469

Summaries for Acute Megakaryoblastic Leukemia Without Down Syndrome

MalaCards based summary : Acute Megakaryoblastic Leukemia Without Down Syndrome, also known as non-ds-amkl, is related to megakaryocytic leukemia. An important gene associated with Acute Megakaryoblastic Leukemia Without Down Syndrome is CBFA2T3 (CBFA2/RUNX1 Partner Transcriptional Co-Repressor 3). Affiliated tissues include myeloid.

Related Diseases for Acute Megakaryoblastic Leukemia Without Down Syndrome

Diseases related to Acute Megakaryoblastic Leukemia Without Down Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 megakaryocytic leukemia 31.3 GLIS2 CBFA2T3

Symptoms & Phenotypes for Acute Megakaryoblastic Leukemia Without Down Syndrome

Drugs & Therapeutics for Acute Megakaryoblastic Leukemia Without Down Syndrome

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Analysis of MicroRNA Expression in Down Syndrome Acute Myeloid Leukemia and the Transient Myeloproliferative Disorder Completed NCT01511575

Search NIH Clinical Center for Acute Megakaryoblastic Leukemia Without Down Syndrome

Genetic Tests for Acute Megakaryoblastic Leukemia Without Down Syndrome

Anatomical Context for Acute Megakaryoblastic Leukemia Without Down Syndrome

MalaCards organs/tissues related to Acute Megakaryoblastic Leukemia Without Down Syndrome:

40
Myeloid

Publications for Acute Megakaryoblastic Leukemia Without Down Syndrome

Articles related to Acute Megakaryoblastic Leukemia Without Down Syndrome:

(show all 24)
# Title Authors PMID Year
1
Acute Megakaryocytic Leukemia. 61
31548219 2020
2
The changing scenario of non-Down syndrome acute megakaryoblastic leukemia in children. 61
31092368 2019
3
CBFA2T3-GLIS2-positive acute myeloid leukaemia. A peculiar paediatric entity. 61
30592296 2019
4
[Prognostic significance of chimeric fusion gene analysis in pediatric acute megakaryoblastic leukemia]. 61
30842387 2019
5
New hPSC-based human models to study pediatric Acute Megakaryoblastic Leukemia harboring the fusion oncogene RBM15-MKL1. 61
28412998 2017
6
Pediatric non-Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes. 61
28112737 2017
7
Disulfiram overcomes bortezomib and cytarabine resistance in Down-syndrome-associated acute myeloid leukemia cells. 61
28143565 2017
8
Hh/Gli antagonist in acute myeloid leukemia with CBFA2T3-GLIS2 fusion gene. 61
28109323 2017
9
Clinical Courses of Two Pediatric Patients with Acute Megakaryoblastic Leukemia Harboring the CBFA2T3-GLIS2 Fusion Gene. 61
27094503 2016
10
The biology of pediatric acute megakaryoblastic leukemia. 61
26186939 2015
11
Acute megakaryoblastic leukemia associated with trisomy 21 demonstrates a distinct immunophenotype. 61
25361478 2015
12
Acute megakaryoblastic leukemia with acquired trisomy 21 and GATA1 mutations in phenotypically normal children. 61
25266042 2015
13
Integrated differential transcriptome maps of Acute Megakaryoblastic Leukemia (AMKL) in children with or without Down Syndrome (DS). 61
25476127 2014
14
Acute Megakaryoblastic Leukemia Associated with Trisomy 21 Demonstrates a Distinct Immunophenotype. 61
25302938 2014
15
The landscape of somatic mutations in Down syndrome-related myeloid disorders. 61
24056718 2013
16
Overexpression of GATA1 confers resistance to chemotherapy in acute megakaryocytic Leukemia. 61
23874683 2013
17
An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia. 61
23153540 2012
18
Molecular lesions in childhood and adult acute megakaryoblastic leukaemia. 61
22122069 2012
19
RUNX1 regulates phosphoinositide 3-kinase/AKT pathway: role in chemotherapy sensitivity in acute megakaryocytic leukemia. 61
19638627 2009
20
Acute megakaryoblastic leukaemia (AMKL) in children: a comparison of AMKL with and without Down syndrome. 61
18275433 2008
21
CD36 (thrombospondin receptor) expression in childhood acute megakaryoblastic leukemia: in vitro drug sensitivity and outcome. 61
17071479 2006
22
Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling. 61
16492768 2006
23
Differential gene expression, GATA1 target genes, and the chemotherapy sensitivity of Down syndrome megakaryocytic leukemia. 61
16249385 2006
24
Transcriptional regulation of the cystathionine-beta -synthase gene in Down syndrome and non-Down syndrome megakaryocytic leukemia cell lines. 61
12393509 2003

Variations for Acute Megakaryoblastic Leukemia Without Down Syndrome

Expression for Acute Megakaryoblastic Leukemia Without Down Syndrome

Search GEO for disease gene expression data for Acute Megakaryoblastic Leukemia Without Down Syndrome.

Pathways for Acute Megakaryoblastic Leukemia Without Down Syndrome

GO Terms for Acute Megakaryoblastic Leukemia Without Down Syndrome

Biological processes related to Acute Megakaryoblastic Leukemia Without Down Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 8.96 GLIS2 CBFA2T3
2 negative regulation of transcription, DNA-templated GO:0045892 8.62 GLIS2 CBFA2T3

Sources for Acute Megakaryoblastic Leukemia Without Down Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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