AMKL
MCID: ACT250
MIFTS: 63

Acute Megakaryocytic Leukemia (AMKL)

Categories: Blood diseases, Cancer diseases, Cardiovascular diseases, Immune diseases, Rare diseases

Aliases & Classifications for Acute Megakaryocytic Leukemia

MalaCards integrated aliases for Acute Megakaryocytic Leukemia:

Name: Acute Megakaryocytic Leukemia 12 20 58 37
Acute Megakaryoblastic Leukemia 20 58 29 6
Acute Megakaryoblastic Leukaemia 17 32
Acute Myeloid Leukemia M7 20 58
Aml M7 20 58
Amkl 20 58
Acute Myeloblastic Leukemia Type 7 20
Leukemia, Megakaryoblastic, Acute 44
Megakaryoblastic Leukemia Acute 54
Acute Megakaryocytic Leukemias 70
Leukemia, Myelocytic, Acute 70
Megakaryocytic Myelosis 12
Megakaryocytic Leukemia 15
Thrombocytic Leukaemia 12

Characteristics:

Orphanet epidemiological data:

58
acute megakaryoblastic leukemia
Inheritance: Not applicable; Age of onset: Childhood;

Classifications:

Orphanet: 58  
Rare haematological diseases


External Ids:

Disease Ontology 12 DOID:8761
ICD9CM 34 207.2
MeSH 44 D007947
NCIt 50 C3170
SNOMED-CT 67 52220008
ICD10 32 C94.2
ICD10 via Orphanet 33 C94.2
UMLS via Orphanet 71 C0023462
Orphanet 58 ORPHA518
UMLS 70 C0023462 C0023467

Summaries for Acute Megakaryocytic Leukemia

GARD : 20 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 518 Definition A rare acute myeloid leukemia that occurs predominantly in childhood and particularly in children with Down syndrome (DS-AMKL). Nonspecific symptoms may be irritability, weakness, and dizziness while specific symptoms include pallor, fever, mucocutaneous bleeding, hepatosplenomegaly, neurological manifestations and rarely lymphadenopathy. Acute panmyelosis with myelofibrosis may also be associated with AMKL. In contrast to DS-AMKL (around 80 % survival), non-DS-AMKL is an AML subgroup associated with poor prognosis.

MalaCards based summary : Acute Megakaryocytic Leukemia, also known as acute megakaryoblastic leukemia, is related to acute leukemia and leukemia, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Acute Megakaryocytic Leukemia is GATA1 (GATA Binding Protein 1), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. The drugs Prednisone and Lenograstim have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone marrow and bone, and related phenotypes are Reduced mammosphere formation and hematopoietic system

Disease Ontology : 12 An acute myeloid leukemia that derives from blood-forming tissue in which megakaryocytes proliferate in the bone marrow and circulate in the blood in large numbers.

Wikipedia : 73 Acute megakaryoblastic leukemia (AMKL) is life-threatening leukemia in which malignant megakaryoblasts... more...

Related Diseases for Acute Megakaryocytic Leukemia

Diseases related to Acute Megakaryocytic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 223)
# Related Disease Score Top Affiliating Genes
1 acute leukemia 31.3 THPO RUNX1 MRTFA MPO KMT2A IL3
2 leukemia 31.3 TP53 THPO RUNX1 MRTFA KMT2A JAK3
3 megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13) 31.2 RBM15 MRTFA
4 myelofibrosis 31.2 TP53 THPO RUNX1 MPO JAK3 IL3
5 thrombocytopenia 31.1 THPO RUNX1 PTEN PF4 IL3 IL11
6 pancytopenia 31.1 TP53 THPO RUNX1 KMT2A IL3 CSF2
7 leukemia, acute myeloid 31.0 TP53 THPO RUNX1 RBM15 PTEN MPO
8 myeloid leukemia 30.9 TP53 RUNX1 MPO KMT2A IL3 CSF2
9 childhood leukemia 30.8 TP53 RUNX1 MPO KMT2A JAK3 AKT1
10 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 30.8 RUNX1 MPO KMT2A
11 mixed phenotype acute leukemia 30.7 RUNX1 MPO KMT2A
12 leukemia, acute monocytic 30.7 MPO KMT2A ANXA5
13 monocytic leukemia 30.7 RUNX1 MPO KMT2A CSF2
14 myeloproliferative syndrome, transient 30.7 TP53 THPO RBM15 JAK3 GATA1
15 thrombocytosis 30.6 THPO PF4 IL3 IL11 CSF2
16 myeloproliferative neoplasm 30.6 THPO RUNX1 PF4 MPO KMT2A JAK3
17 peripheral nervous system disease 30.6 TP53 PTEN CSF2 ANXA5 AKT1
18 hematologic cancer 30.6 THPO RUNX1 KMT2A IL3 IL11 CSF2
19 neutropenia 30.6 TP53 THPO MPO IL3 IL11 CSF2
20 polycythemia vera 30.5 TP53 THPO PF4 JAK3 IL3 CSF2
21 chronic myelomonocytic leukemia 30.5 TP53 RUNX1 MPO KMT2A CSF2
22 essential thrombocythemia 30.5 TP53 THPO PF4 MPO IL3 IL11
23 acute promyelocytic leukemia 30.4 TP53 THPO RUNX1 PTEN MPO KMT2A
24 leukemia, chronic myeloid 30.3 TP53 THPO RUNX1 MPO KMT2A IL3
25 myelodysplastic syndrome 30.3 TP53 THPO RUNX1 PTEN MPO KMT2A
26 leukemia, acute lymphoblastic 30.2 TP53 THPO RUNX1 PTEN MPO KMT2A
27 childhood acute megakaryoblastic leukemia 11.2
28 myeloid leukemia associated with down syndrome 11.2
29 down syndrome 10.6
30 neonatal leukemia 10.6 RBM15 MRTFA GATA1
31 childhood t-cell acute lymphoblastic leukemia 10.5 PTEN ANXA5 AKT1
32 skin papilloma 10.5 TP53 PTEN AKT1
33 leukemia, acute lymphoblastic 3 10.5 TP53 RUNX1 KMT2A
34 germ cells tumors 10.5
35 lung oat cell carcinoma 10.5 TP53 PTEN AKT1
36 amegakaryocytic thrombocytopenia, congenital 10.5 THPO IL3 GATA1
37 penile disease 10.5 TP53 PTEN AKT1
38 respiratory system benign neoplasm 10.5 TP53 PTEN AKT1
39 ovarian cystadenocarcinoma 10.5 TP53 PTEN AKT1
40 uterine benign neoplasm 10.5 TP53 PTEN AKT1
41 reproductive organ benign neoplasm 10.5 TP53 PTEN AKT1
42 uterine corpus cancer 10.5 TP53 PTEN AKT1
43 thymus gland disease 10.5 TP53 PTEN AKT1
44 splenic artery aneurysm 10.5 THPO MPO
45 thymus cancer 10.5 TP53 PTEN AKT1
46 acute basophilic leukemia 10.5 MPO GATA1
47 tongue disease 10.5 TP53 PTEN ANXA5 AKT1
48 ovary adenocarcinoma 10.5 TP53 PTEN AKT1
49 cardiovascular organ benign neoplasm 10.5 TP53 PTEN AKT1
50 granulocytopenia 10.5 MPO IL3 CSF2

Comorbidity relations with Acute Megakaryocytic Leukemia via Phenotypic Disease Network (PDN):


Acquired Thrombocytopenia Deficiency Anemia
Neutropenia

Graphical network of the top 20 diseases related to Acute Megakaryocytic Leukemia:



Diseases related to Acute Megakaryocytic Leukemia

Symptoms & Phenotypes for Acute Megakaryocytic Leukemia

UMLS symptoms related to Acute Megakaryocytic Leukemia:


angina pectoris; chest pain; edema

GenomeRNAi Phenotypes related to Acute Megakaryocytic Leukemia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 GATA1 JAK3 KMT2A PTEN RUNX1 SRF

MGI Mouse Phenotypes related to Acute Megakaryocytic Leukemia:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.34 AKT1 ANXA5 CSF2 GATA1 JAK3 KMT2A
2 cellular MP:0005384 10.31 AKT1 CSF2 ETS2 GATA1 JAK3 KMT2A
3 cardiovascular system MP:0005385 10.29 AKT1 CSF2 ETS2 GATA1 JAK3 KMT2A
4 homeostasis/metabolism MP:0005376 10.25 AKT1 CSF2 ETS2 GATA1 KMT2A MPO
5 immune system MP:0005387 10.24 AKT1 ANXA5 CSF2 GATA1 JAK3 KMT2A
6 embryo MP:0005380 10.18 AKT1 CSF2 ETS2 GATA1 KMT2A PTEN
7 endocrine/exocrine gland MP:0005379 10.16 AKT1 CSF2 ETS2 JAK3 MRTFA PTEN
8 mortality/aging MP:0010768 10.13 AKT1 CSF2 ETS2 GATA1 JAK3 KMT2A
9 integument MP:0010771 10.02 AKT1 CSF2 ETS2 GATA1 KMT2A MRTFA
10 neoplasm MP:0002006 9.76 AKT1 CSF2 ETS2 KMT2A PTEN RBM15
11 normal MP:0002873 9.65 AKT1 ANXA5 ETS2 GATA1 KMT2A PTEN
12 respiratory system MP:0005388 9.23 AKT1 CSF2 GATA1 PTEN RUNX1 SRF

Drugs & Therapeutics for Acute Megakaryocytic Leukemia

Drugs for Acute Megakaryocytic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 163)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
2
Lenograstim Approved, Investigational Phase 3 135968-09-1
3
Sirolimus Approved, Investigational Phase 3 53123-88-9 6436030 5284616
4
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
5
Cladribine Approved, Investigational Phase 3 4291-63-8 20279
6
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
7
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
8
Mercaptopurine Approved Phase 3 50-44-2 667490
9
Posaconazole Approved, Investigational, Vet_approved Phase 3 171228-49-2 147912
10
Aldesleukin Approved Phase 3 85898-30-2, 110942-02-4
11
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
12
Hydrocortisone acetate Approved, Vet_approved Phase 3 50-03-3
13
Cytarabine Approved, Investigational Phase 3 147-94-4 6253
14
Daunorubicin Approved Phase 3 20830-81-3 30323
15
Clofarabine Approved, Investigational Phase 3 123318-82-1 119182
16
Azacitidine Approved, Investigational Phase 3 320-67-2 9444
17
Decitabine Approved, Investigational Phase 3 2353-33-5 451668
18
Thioguanine Approved Phase 3 154-42-7 2723601
19
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
20
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
21
Fludarabine Approved Phase 3 21679-14-1, 75607-67-9 30751
22
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
23
Voriconazole Approved Phase 3 137234-62-9 71616
24
Vidarabine Approved, Investigational Phase 3 24356-66-9 21704 32326
25
Melphalan Approved Phase 3 148-82-3 4053 460612
26
Busulfan Approved, Investigational Phase 3 55-98-1 2478
27
Aspartic acid Approved, Nutraceutical Phase 3 56-84-8 5960
28
tipifarnib Investigational Phase 3 192185-72-1 159324
29 glucocorticoids Phase 3
30 Antineoplastic Agents, Hormonal Phase 3
31 Anti-Inflammatory Agents Phase 3
32 Gastrointestinal Agents Phase 3
33 Analgesics, Non-Narcotic Phase 3
34 Antiemetics Phase 3
35 Antiparasitic Agents Phase 3
36 Antiprotozoal Agents Phase 3
37 Anti-Retroviral Agents Phase 3
38 Interleukin-2 Phase 3
39 Hydrocortisone-17-butyrate Phase 3
40 Hydrocortisone hemisuccinate Phase 3
41 Anti-HIV Agents Phase 3
42 BB 1101 Phase 3
43 Hydrocortisone 17-butyrate 21-propionate Phase 3
44 Anti-Infective Agents Phase 3
45 Immunosuppressive Agents Phase 3
46 Immunologic Factors Phase 3
47 Anti-Bacterial Agents Phase 3
48 Antibiotics, Antitubercular Phase 3
49 Antiviral Agents Phase 3
50 Antimetabolites Phase 3

Interventional clinical trials:

(show top 50) (show all 102)
# Name Status NCT ID Phase Drugs
1 A Phase IV Study of Corticosteroids As Prophylaxis for Infusion-Related Adverse Events to Mylotarg® in Patients With Acute Myelogenous Leukemia (AML) Completed NCT00304447 Phase 4 Mylotarg
2 Phase III Study of MDR Modulation With PSC-833 (NSC #648265) Followed by Immunotherapy With rIL-2 (NSC #373364) vs. No Further Therapy in Previously Untreated Patients With AML >60 Years Completed NCT00003190 Phase 3 cytarabine;daunorubicin hydrochloride;etoposide;valspodar
3 A Phase III Randomized, Multicenter Trial Comparing Sirolimus/Tacrolimus With Tacrolimus/Methotrexate as Graft-versus-Host Disease (GVHD) Prophylaxis After HLA-Matched, Related Peripheral Blood Stem Cell Transplantation (BMT CTN #0402) Completed NCT00406393 Phase 3 Tacrolimus;Methotrexate;Sirolimus
4 A Collaborative Trial for the Treatment of Patients With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplasia Completed NCT00136084 Phase 3 Cladribine, Cyclophosphamide, Cytarabine, Daunorubicin, Dexamethasone;Etoposide, Cytarabine, Gemtuzumab, L-asparaginase, Mercaptopurine, methotrexate, Mitoxantrone, Prednisone, Vincristine
5 A Randomized Controlled Trial of Posaconazole (SCH 56592) vs. Standard Azole Therapy for the Prevention of Invasive Fungal Infections Among High-Risk Neutropenic Patients Completed NCT00044486 Phase 3 Posaconazole oral suspension
6 A Randomized Study of Two Doses Gemtuzumab Ozogamicin vs. A Two-year Maintenance With Atra Plus Chemotherapy as Post-consolidation Treatment for Intermediate and High-risk Adult Patients With Acute Promyelocytic Leukemia (Apl) Completed NCT00962767 Phase 3 gemtuzumab ozogamicin;ATRA plus 6-MP and MTX
7 A PHASE III STUDY IN CHILDREN WITH UNTREATED ACUTE MYELOGENOUS LEUKEMIA (AML) OR MYELODYSPLASTIC SYNDROME (MDS) Completed NCT00002798 Phase 3 asparaginase;daunorubicin hydrochloride;fludarabine phosphate;therapeutic hydrocortisone;cytarabine;idarubicin;dexamethasone;thioguanine;etoposide;methotrexate;cyclophosphamide;busulfan
8 A Phase III Randomized Study of Farnesyl Transferase Inhibitor R115777 in Acute Myeloid Leukemia (AML) Patients in Second or Subsequent Remission or in Remission After Primary Induction Failure or Patients Over Age 60 in First Remission Completed NCT00093470 Phase 3 Tipifarnib
9 Phase III Randomized Study of Induction Chemotherapy With or Without MDR-Modulation With PSC-833 (NSC # 648265, IND # 41121) Followed by Cytogenetic Risk-Adapted Intensification Therapy Followed by Immunotherapy With rIL-2 (NSC # 373364, IND # 1969) vs. Observation in Previously Untreated Patients With AML < 60 Years Completed NCT00006363 Phase 3 cytarabine;daunorubicin hydrochloride;etoposide;valspodar;busulfan
10 Randomized Comparison Between Two Dose Levels of Daunorubicin and Between One Versus Two Cycles of Induction Therapy for Adult Patients With Acute Myeloid Leukemia ≤65 Years Recruiting NCT02140242 Phase 3 study part 1 - dose daunorubicin
11 The Treatment of Down Syndrome Children With Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS) Under the Age of 4 Years Active, not recruiting NCT00369317 Phase 3 asparaginase;daunorubicin hydrochloride;cytarabine;thioguanine;etoposide
12 Phase III Randomized Trial of Clofarabine as Induction and Post-Remission Therapy vs. Standard Daunorubicin &Amp; Cytarabine Induction and Intermediate Dose Cytarabine Post-Remission Therapy, Followed by Decitabine Maintenance vs. Observation in Newly-Diagnosed Acute Myeloid Leukemia in Older Adults (Age >/= 60 Years) Active, not recruiting NCT02085408 Phase 3 clofarabine;daunorubicin hydrochloride;cytarabine;decitabine
13 Phase III Study of Safety, Tolerance, Efficacy, Pharmacokinetics, and Costs of Therapy With Voriconazole or Placebo in the Prophylaxis of Lung Infiltrates in Patients Undergoing Induction Chemotherapy for Acute Myelogenous Leukemia Terminated NCT00152594 Phase 3 voriconazole
14 A Randomized, Multi-Center, Phase III Study of Allogeneic Stem Cell Transplantation Comparing Regimen Intensity in Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia (BMT CTN #0901) Terminated NCT01339910 Phase 3 Fludarabine and Busulfan;Fludarabine and Melphalan;Busulfan and Fludarabine;Busulfan and Cyclophosphamide;Cyclophosphamide and Total Body Irradiation
15 Phase II Study of Cladribine, High-dose Cytarabine and Idarubicin in Patients With Relapsed Acute Myeloid Leukemia Unknown status NCT00126321 Phase 2 cladribine
16 A Phase 2, Prospective, Randomized, Multicenter, Double-blind, Active-control, Parallel-group Study to Determine the Safety of and to Select a Treatment Regimen of CC-4047 (Pomalidomide) Either as Single-agent or in Combination With Prednisone to Study Further in Subjects With Myelofibrosis With Myeloid Metaplasia Completed NCT00463385 Phase 2 Pomalidomide;Prednisone;Placebo to pomalidomide;Placebo to prednisone
17 Phase II Studies of Two Different Schedules and Two Different Doses of the Farnesyl Transferase Inhibitor R115777 (Tipifarnib, Zarnestra®, NSC-702818) for Previously Untreated Acute Myeloid Leukemia (AML) in Patients of Age 70 or Older Completed NCT00093418 Phase 2 tipifarnib
18 Phase 2 Study of Early Discharge and Outpatient Management of Adult Patients Following Intensive Chemotherapy for MDS and Non-APL AML Completed NCT01235572 Phase 2
19 Randomized Phase II Trial of Timed Sequential Cytosine Arabinoside (Ara-C) With and Without the Checkpoint Kinase 1 (CHK1) Inhibitor MK-8776 in Adults With Relapsed AML Completed NCT01870596 Phase 2 Cytarabine;CHK1 Inhibitor SCH 900776
20 A Phase 2 Study of the AKT Kinase Inhibitor MK-2206 in Patients With Relapsed Refractory Acute Myelogenous Leukemia Completed NCT01253447 Phase 2 Akt inhibitor MK2206
21 Phase 2 Trial of R115777 in Previously Untreated Older Adults With AML and Baseline Presence of a Specific 2-Gene Expression Signature Ratio Completed NCT01361464 Phase 2 Tipifarnib
22 A Phase II Randomized Trial of Carboplatin and Topotecan; Flavopiridol, Mitoxantrone and Cytosine Arabinoside; and Sirolimus, Mitoxantrone, Etoposide and Cytosine Arabinoside for the Treatment of Adults With Primary Refractory or Initial Relapse of Acute Myelogenous Leukemia (AML) Completed NCT00634244 Phase 2 alvocidib;mitoxantrone hydrochloride;carboplatin;cytarabine;sirolimus;etoposide;topotecan hydrochloride
23 A Randomized Phase II Study of Nuclear Factor-kappa B (NF-κB) Inhibition During Induction Chemotherapy for Patients With Acute Myelogenous Leukemia Completed NCT02144675 Phase 2 choline magnesium trisalicylate;idarubicin;cytarabine
24 A Phase 1/2 Study of Vorinostat (Zolinza®) in Combination With Gemtuzumab Ozogamicin (Mylotarg®) and Azacitidine (Vidaza®) in Patients 50 Years of Age and Older With Relapsed/Refractory Non-APL Acute Myeloid Leukemia (AML) Completed NCT00895934 Phase 1, Phase 2 vorinostat;gemtuzumab ozogamicin;azacitidine
25 A Single Arm, Multicenter Phase II Trial of Transplants of HLA-Matched, CD34+ Enriched, T Cell Depleted Peripheral Blood Stem Cells Isolated by the CliniMACS System in the Treatment of Patients With AML in First or Second Morphologic Complete Remission (BMT CTN #0303) Completed NCT00201240 Phase 2
26 Autologous Bone Marrow Transplantation for Acute Non-Lymphoblastic Leukemia During First or Subsequent Remission Completed NCT00186381 Phase 2
27 A Phase II, Open Label Study of Clofarabine in Pediatric Patients With Refractory or Relapsed Acute Myelogenous Leukemia Completed NCT00042354 Phase 2 clofarabine (IV formulation)
28 Risk Adapted Treatment for Primary AML in Adults, Based on Genetics and Minimal Residual Disease (MRD) in Patients up to the Age of 70 Years. Completed NCT01723657 Phase 2 Ara-C;G-CSF
29 Risk Adapted Treatment for Primary AML in Adults up to the Age of 60 Years. Completed NCT01716793 Phase 2 Ara-C
30 PHASE I-II STUDY OF IDARUBICIN, CYTARABINE AND R115777 (TIPIFARNIB, ZARNESTRA; 702818; IND 58359), A FARNESYLTRANSFERASE INHIBITOR, IN PATIENTS WITH HIGH-RISK MYELODYSPLASTIC SYNDROMES AND ACUTE MYELOID LEUKEMIAS Completed NCT00096122 Phase 1, Phase 2 cytarabine;idarubicin;tipifarnib
31 A Phase II Study of and Oral Histone Deacytylase Inhibitor, MS-275 (NSC 706995), in Combination With Sargramostim (GM-CSF, Berlex, Inc.) Treating Relapsed and Refractory Myeloid Malignancies Completed NCT00462605 Phase 2 entinostat;sargramostim
32 A Phase II Study of Lenalidomide (REVLIMID, NSC-703813) for Previously Untreated Non-M3, Deletion 5q Acute Myeloid Leukemia (AML) in Patients Age 60 or Older Who Decline Remission Induction Chemotherapy Completed NCT00352365 Phase 2 lenalidomide
33 A Phase 2 Study of Suberoylanilide Hydroxamic Acid (SAHA) in Acute Myeloid Leukemia (AML) Completed NCT00305773 Phase 2 vorinostat;vorinostat
34 Nonmyeloablative Allogeneic Peripheral Blood Stem Cell Transplantation From HLA Matched Related Donors for Treatment of Older Patients With De Novo or Secondary Acute Myeloid Leukemia in First Complete Remission Completed NCT00045435 Phase 2 fludarabine phosphate;cyclosporine;mycophenolate mofetil
35 High-dose Busulfan, High-dose Cyclophosphamide, and Allogeneic Bone Marrow Transplantation for Leukemia, Myelodysplastic Syndromes, Multiple Myeloma and Lymphoma Completed NCT01177371 Phase 2 busulfan;cyclophosphamide;methylprednisolone;methotrexate;cyclosporine
36 Umbilical Cord Blood (UCB) Allogeneic Stem Cell Transplant for Hematologic Malignancies Completed NCT01093586 Phase 2 busulfan;cyclophosphamide;anti-thymocyte globulin;methylprednisolone;cyclosporine;mycophenolate mofetil
37 Phase II Study of Alvocidib (NSC 649890, Flavopiridol) in Timed Sequential Combination With Cytosine Arabinoside (Ara-C) and Mitoxantrone for Adults With Newly Diagnosed, Previously Untreated, Poor-Risk Acute Myelogenous Leukemias Completed NCT00407966 Phase 2 alvocidib;cytarabine;mitoxantrone hydrochloride
38 A Phase II Study of Farnesyl Transferase Inhibitor R115777 (Zarnestra) (R115777 ( Zarnestra), Tipifarnib, R115777, NSC #702818) in Elderly Patients With Previously Untreated Poor-Risk Acute Myeloid Leukemia Completed NCT00027872 Phase 2 tipifarnib
39 A Randomized Phase II Trial of Tipifarnib (R115777, ZARNESTRA, NSC #702818) in Combination With Oral Etoposide (VP-16) in Elderly Adults With Newly Diagnosed, Previously Untreated Acute Myelogenous Leukemia (AML) Completed NCT00602771 Phase 2 tipifarnib;etoposide
40 A Phase II Study of CPX-351 for Treatment of AML or Higher Risk MDS Relapsed or Refractory to Prior Therapy With Hypomethylating (HMA) Agent Completed NCT02019069 Phase 2 liposomal cytarabine-daunorubicin CPX-351
41 A Phase II Pilot Study of Bortezomib (PS-341, Velcade) Combined With Reinduction Chemotherapy in Children and Young Adults With Recurrent, Refractory or Secondary Acute Myeloid Leukemia Completed NCT00666588 Phase 2 idarubicin;cytarabine;bortezomib;etoposide
42 A Phase II Study to Evaluate the Efficacy of Posttransplant Cyclophosphamide for Prevention of Chronic Graft-versus-Host Disease After Allogeneic Peripheral Blood Stem Cell Transplantation Completed NCT01427881 Phase 2 cyclophosphamide;cyclosporine;fludarabine phosphate;busulfan
43 Randomized Phase II Study Comparing Two Administration Schedules of Flavopiridol (Alvocidib, NSC 649890, IND 46, 211) Given in Timed Sequential Combination With Cytosine Arabinoside (Ara-C) and Mitoxantrone Hydrochloride for Adults With Newly Diagnosed, Previously Untreated, Poor Risk Acute Myelogenous Leukemias (AML) Completed NCT00795002 Phase 2 alvocidib;mitoxantrone hydrochloride;cytarabine
44 Dose Escalation and Phase II Study of Bortezomib (IND #58443) Added to Standard Daunorubicin and Cytarabine Therapy for Patients With Previously Untreated Acute Myeloid Leukemia Age 60-75 Years Completed NCT00742625 Phase 1, Phase 2 daunorubicin hydrochloride;cytarabine;bortezomib
45 Infusion of Off-the-Shelf Ex Vivo Expanded Cryopreserved Progenitor Cells to Facilitate the Engraftment of a Single CCR5Δ32 Homozygous or Heterozygous Cord Blood Unit in Patients With HIV and Hematological Malignancies Recruiting NCT04083170 Phase 2 Fludarabine;Cyclophosphamide;Thiotepa
46 A Phase 1/2 Study of Vorinostat [Suberoylanilide Hydroxamic Acid (SAHA)] in Combination With Azacitidine in Patients With the Myelodysplastic Syndrome (MDS) Active, not recruiting NCT00392353 Phase 1, Phase 2 Azacitidine;Vorinostat
47 NK Cells With HLA Compatible Hematopoietic Transplantation for High Risk Myeloid Malignancies Active, not recruiting NCT01823198 Phase 1, Phase 2 Busulfan;Fludarabine Phosphate
48 Phase II Study of the Addition of Azacitidine (NSC#102816) to Reduced-Intensity Conditioning Allogeneic Transplantation for Myelodysplasia (MDS) and Older Patients With AML Active, not recruiting NCT01168219 Phase 2 Azacitidine;Busulfan;Fludarabine Phosphate;Methotrexate;Tacrolimus
49 A Single Arm, Phase II Study of Eltrombopag to Enhance Platelet Count Recovery in Elderly Patients With Acute Myeloid Leukemia Undergoing Remission Induction Therapy Active, not recruiting NCT02071901 Phase 2 eltrombopag olamine
50 A Phase II Trial of Azacitidine (NSC-102816) Plus Gemtuzumab Ozogamicin (NSC-720568) as Induction and Post-Remission Therapy in Patients of Age 60 and Older With Previously Untreated Non-M3 Acute Myeloid Leukemia Active, not recruiting NCT00658814 Phase 2 Azacitidine;Gemtuzumab Ozogamicin

Search NIH Clinical Center for Acute Megakaryocytic Leukemia

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Cyclophosphamide
Etoposide
etoposide phosphate
Idarubicin
Idarubicin Hydrochloride
Mitoxantrone
Mitoxantrone Hydrochloride

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Acute Megakaryocytic Leukemia cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: leukemia, megakaryoblastic, acute

Genetic Tests for Acute Megakaryocytic Leukemia

Genetic tests related to Acute Megakaryocytic Leukemia:

# Genetic test Affiliating Genes
1 Acute Megakaryoblastic Leukemia 29

Anatomical Context for Acute Megakaryocytic Leukemia

MalaCards organs/tissues related to Acute Megakaryocytic Leukemia:

40
Myeloid, Bone Marrow, Bone, T Cells, Nk Cells, Skin, Placenta

Publications for Acute Megakaryocytic Leukemia

Articles related to Acute Megakaryocytic Leukemia:

(show top 50) (show all 719)
# Title Authors PMID Year
1
Activating alleles of JAK3 in acute megakaryoblastic leukemia. 6 61 54
16843266 2006
2
The GATA1 mutation in an adult patient with acute megakaryoblastic leukemia not accompanying Down syndrome. 6 61 54
15070711 2004
3
The MLL recombinome of acute leukemias in 2017. 6
28701730 2018
4
Functional analysis of JAK3 mutations in transient myeloproliferative disorder and acute megakaryoblastic leukaemia accompanying Down syndrome. 6
18397343 2008
5
A rare case of GATA1 negative chemoresistant acute megakaryocytic leukemia in an 8-month-old infant with trisomy 21. 54 61
20108342 2010
6
Megakaryocytic blast crisis in a chronic myeloid leukemia patient with a rare variant of Philadelphia rearrangement t(9;22;22) and a constitutional translocation t(3;7). 61 54
20417868 2010
7
NSC114792, a novel small molecule identified through structure-based computational database screening, selectively inhibits JAK3. 54 61
20149240 2010
8
JAK3: a two-faced player in hematological disorders. 54 61
19747563 2009
9
GATA-2 reinforces megakaryocyte development in the absence of GATA-1. 54 61
19620289 2009
10
Induction of hyperproliferative fetal megakaryopoiesis by an N-terminally truncated GATA1 mutant. 61 54
19682090 2009
11
Mutational spectrum at GATA1 provides insights into mutagenesis and leukemogenesis in Down syndrome. 61 54
19633202 2009
12
Vesiculopustular eruption associated with transient myeloproliferative disorder. 54 61
19537279 2009
13
Role for MKL1 in megakaryocytic maturation. 54 61
19136660 2009
14
A novel mutation in the GATA1 gene associated with acute megakaryoblastic leukemia in a Korean Down syndrome patient. 54 61
19119459 2008
15
Tetrasomy 21 as a sole acquired abnormality without GATA1 gene mutation in pediatric acute megakaryoblastic leukemia: a case report and review of the literature. 54 61
18372039 2008
16
JAKs in pathology: role of Janus kinases in hematopoietic malignancies and immunodeficiencies. 61 54
18682296 2008
17
JAK and MPL mutations in myeloid malignancies. 54 61
18297515 2008
18
Mining for JAK-STAT mutations in cancer. 61 54
18291658 2008
19
The role of the proto-oncogene ETS2 in acute megakaryocytic leukemia biology and therapy. 61 54
18094719 2008
20
Incidence and clinical implications of GATA1 mutations in newborns with Down syndrome. 54 61
17576817 2007
21
Severe TMD/AMKL with GATA1 mutation in a stillborn fetus with Down syndrome. 54 61
17597708 2007
22
JAK3 mutations occur in acute megakaryoblastic leukemia both in Down syndrome children and non-Down syndrome adults. 54 61
17252020 2007
23
[The role of GATA1 mutation in acute megakaryocytic leukemia]. 61 54
17176883 2006
24
CD36 (thrombospondin receptor) expression in childhood acute megakaryoblastic leukemia: in vitro drug sensitivity and outcome. 54 61
17071479 2006
25
Physical association of the patient-specific GATA1 mutants with RUNX1 in acute megakaryoblastic leukemia accompanying Down syndrome. 61 54
16628190 2006
26
Acute megakaryoblastic leukemia and loss of the RUNX1 gene. 61 54
16364766 2006
27
Early block to erythromegakaryocytic development conferred by loss of transcription factor GATA-1. 61 54
16144799 2006
28
GATA1 as a new target to detect minimal residual disease in both transient leukemia and megakaryoblastic leukemia of Down syndrome. 54 61
15916804 2005
29
GATA 1 mutations as clonal markers of minimal residual disease in acute megakaryoblastic leukemia of Down syndrome--a new tool with significant potential applications. 54 61
15925405 2005
30
MLL-MLLT10 fusion gene in pediatric acute megakaryoblastic leukemia. 61 54
16111539 2005
31
Differential requirements for the activation domain and FOG-interaction surface of GATA-1 in megakaryocyte gene expression and development. 61 54
15860665 2005
32
GATA transcription factors in hematologic disease. 61 54
16158817 2005
33
Increased dosage of Runx1/AML1 acts as a positive modulator of myeloid leukemogenesis in BXH2 mice. 54 61
15856017 2005
34
GATA1, cytidine deaminase, and the high cure rate of Down syndrome children with acute megakaryocytic leukemia. 61 54
15687366 2005
35
GATA1 in normal and malignant hematopoiesis. 54 61
15659348 2005
36
GATA1 mutations in Down syndrome: implications for biology and diagnosis of children with transient myeloproliferative disorder and acute megakaryoblastic leukemia. 61 54
15390312 2005
37
Interleukin-11 as an osteoprotegerin-inducing factor in culture medium of blastic cells from a patient with acute megakaryocytic leukemia complicated with osteosclerosis. 54 61
15307108 2004
38
No mutations in the GATA-1 gene detected in patients with acquired essential thrombocythemia. 61 54
15136229 2004
39
p-Iodophenol-enhanced luminol chemiluminescent assay applied to discrimination between acute lymphoblastic and minimally differentiated acute myeloid (FAB-M0) or acute megakaryoblastic (FAB-M7) leukemias. 61 54
15570291 2004
40
Fetal origin of the GATA1 mutation in identical twins with transient myeloproliferative disorder and acute megakaryoblastic leukemia accompanying Down syndrome. 54 61
14684662 2004
41
Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome. 54 61
14512321 2004
42
Mutations in GATA1 in both transient myeloproliferative disorder and acute megakaryoblastic leukemia of Down syndrome. 61 54
14636651 2003
43
GATA1 mutations in transient leukemia and acute megakaryoblastic leukemia of Down syndrome. 54 61
12586620 2003
44
Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell death. 54 61
12019265 2002
45
Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. 54 61
11431691 2001
46
Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia. 54 61
11344311 2001
47
Detection of platelet-specific protein mRNAs in different megakaryoblasts using the reverse transcriptase polymerase chain reaction. 54 61
1493450 1992
48
Differentiation induction of blast cells in two cases of childhood acute megakaryoblastic leukemia in vitro by interleukin-3 and interleukin-6: an ultrastructural cytochemical study. 54 61
1655816 1991
49
MRTFA: a critical protein in normal and malignant hematopoiesis and beyond. 61
33722605 2021
50
Utility of CD36 as a novel addition to the immunophenotypic signature of RAM-phenotype acute myeloid leukemia and study of its clinicopathological characteristics. 61
32865882 2021

Variations for Acute Megakaryocytic Leukemia

ClinVar genetic disease variations for Acute Megakaryocytic Leukemia:

6 (show all 19)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 GATA1 NM_002049.3(GATA1):c.154_173dup (p.Ala59fs) Duplication Pathogenic 10429 rs398124628 GRCh37: X:48649667-48649668
GRCh38: X:48791260-48791261
2 KMT2A , SEPTIN9 t(11;17)(q23;q25) Translocation Pathogenic 590282 GRCh37:
GRCh38: 11:118482092-118482093
3 PTEN NM_000314.8(PTEN):c.406T>C (p.Cys136Arg) SNV Pathogenic 183726 rs786201044 GRCh37: 10:89692922-89692922
GRCh38: 10:87933165-87933165
4 TP53 NM_000546.5(TP53):c.636del (p.Arg213fs) Deletion Pathogenic 218342 rs864309495 GRCh37: 17:7578213-7578213
GRCh38: 17:7674895-7674895
5 JAK3 NM_000215.3(JAK3):c.2164G>A (p.Val722Ile) SNV Likely pathogenic 134573 rs3213409 GRCh37: 19:17945696-17945696
GRCh38: 19:17834887-17834887
6 JAK3 NM_000215.3(JAK3):c.394C>A (p.Pro132Thr) SNV Likely pathogenic 134580 rs3212723 GRCh37: 19:17954215-17954215
GRCh38: 19:17843406-17843406
7 JAK3 NM_000215.3(JAK3):c.1503G>T (p.Gln501His) SNV Likely pathogenic 376114 rs201283129 GRCh37: 19:17949138-17949138
GRCh38: 19:17838329-17838329
8 JAK3 NM_000215.3(JAK3):c.1970G>A (p.Arg657Gln) SNV Likely pathogenic 376113 rs758959409 GRCh37: 19:17945969-17945969
GRCh38: 19:17835160-17835160
9 JAK3 NM_000215.3(JAK3):c.1715C>T (p.Ala572Val) SNV Likely pathogenic 376037 rs121913504 GRCh37: 19:17948009-17948009
GRCh38: 19:17837200-17837200
10 JAK3 NM_000215.3(JAK3):c.1503G>C (p.Gln501His) SNV Likely pathogenic 376115 rs201283129 GRCh37: 19:17949138-17949138
GRCh38: 19:17838329-17838329
11 JAK3 NM_000215.3(JAK3):c.260T>C (p.Ile87Thr) SNV Likely pathogenic 376116 rs1057519770 GRCh37: 19:17954634-17954634
GRCh38: 19:17843825-17843825
12 RASAL3 NM_022904.3(RASAL3):c.-5C>G SNV Uncertain significance 218343 rs76267899 GRCh37: 19:15575174-15575174
GRCh38: 19:15464363-15464363
13 ACP3 NM_001099.5(ACP3):c.849_851CAT[1] (p.Ile284del) Microsatellite Uncertain significance 218346 rs864309497 GRCh37: 3:132068830-132068832
GRCh38: 3:132349986-132349988
14 PCF11 NM_015885.4(PCF11):c.3225del (p.Phe1075fs) Deletion Uncertain significance 218347 rs864309498 GRCh37: 11:82880600-82880600
GRCh38: 11:83169558-83169558
15 MT-ND6 NC_012920.1:m.14372C>A SNV Uncertain significance 218344 rs1556424431 GRCh37: MT:14372-14372
GRCh38: MT:14372-14372
16 MDGA1 NM_153487.4(MDGA1):c.2674T>G (p.Phe892Val) SNV Uncertain significance 218340 rs864309493 GRCh37: 6:37606083-37606083
GRCh38: 6:37638307-37638307
17 APC NM_000038.6(APC):c.319T>G (p.Ser107Ala) SNV Uncertain significance 620613 rs1485866385 GRCh37: 5:112102984-112102984
GRCh38: 5:112767287-112767287
18 SLC9A2 NM_003048.6(SLC9A2):c.2173del (p.Gln725fs) Deletion Uncertain significance 218345 rs864309496 GRCh37: 2:103324677-103324677
GRCh38: 2:102708218-102708218
19 CORO7-PAM16 , CORO7 NM_024535.5(CORO7):c.2772+50C>T SNV Uncertain significance 218341 rs1555468179 GRCh37: 16:4405237-4405237
GRCh38: 16:4355236-4355236

Copy number variations for Acute Megakaryocytic Leukemia from CNVD:

7
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 158678 21 35304204 35704075 Loss RUNX1 Acute megakaryoblastic leukaemia

Expression for Acute Megakaryocytic Leukemia

Search GEO for disease gene expression data for Acute Megakaryocytic Leukemia.

Pathways for Acute Megakaryocytic Leukemia

Pathways related to Acute Megakaryocytic Leukemia according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.69 TP53 THPO SRF PTEN PF4 JAK3
2
Show member pathways
13.59 TP53 THPO SRF PF4 JAK3 IL3
3
Show member pathways
13.3 TP53 THPO PTEN PF4 JAK3 IL3
4
Show member pathways
13.22 THPO PTEN PF4 IL3 IL11 CSF2
5
Show member pathways
13.13 TP53 THPO PF4 JAK3 IL3 GATA1
6
Show member pathways
12.79 SRF PTEN JAK3 IL11 AKT1
7 12.75 TP53 RUNX1 PTEN JAK3 IL3 AKT1
8
Show member pathways
12.72 TP53 RUNX1 PTEN MPO IL3 CSF2
9 12.45 RUNX1 MRTFA MPO JAK3 IL3 GATA1
10 12.33 TP53 SEPTIN9 CSF2 AKT1
11
Show member pathways
12.32 TP53 PTEN JAK3 AKT1
12
Show member pathways
12.25 JAK3 IL3 ETS2 AKT1
13
Show member pathways
12.13 THPO JAK3 IL3 IL11 CSF2 AKT1
14
Show member pathways
12.06 JAK3 IL3 CSF2 AKT1
15 11.85 TP53 PTEN KMT2A IL3
16 11.84 THPO RUNX1 IL3 IL11 GATA1
17 11.81 THPO IL3 IL11 CSF2
18 11.79 TP53 PTEN AKT1
19 11.75 TP53 PTEN AKT1
20 11.73 TP53 CSF2 AKT1
21 11.72 TP53 RUNX1 MPO KMT2A IL3 CSF2
22 11.7 MPO GATA1 ETS2
23 11.64 TP53 PTEN AKT1
24 11.62 THPO MPO IL3 IL11 CSF2
25 11.61 TP53 PTEN AKT1
26 11.51 TP53 SRF PTEN JAK3 ETS2 CSF2
27 11.5 TP53 PTEN AKT1
28 11.42 TP53 PTEN AKT1
29 11.36 SRF PTEN MRTFA
30 11.35 RUNX1 IL3 GATA1 CSF2
31 11.17 IL3 IL11 CSF2
32 10.94 THPO SEPTIN9 PF4 IL3 IL11 CSF2

GO Terms for Acute Megakaryocytic Leukemia

Cellular components related to Acute Megakaryocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.36 TP53 SRF RUNX1 RBM15 PTEN MRTFA

Biological processes related to Acute Megakaryocytic Leukemia according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10 TP53 PTEN PF4 CSF2 AKT1
2 positive regulation of cell proliferation GO:0008284 9.95 THPO PTEN IL3 IL11 CSF2 AKT1
3 negative regulation of apoptotic process GO:0043066 9.93 TP53 PTEN MPO GATA1 ANXA5 AKT1
4 positive regulation of transcription, DNA-templated GO:0045893 9.91 TP53 SRF RUNX1 KMT2A GATA1 ETS2
5 positive regulation of transcription by RNA polymerase II GO:0045944 9.85 TP53 SRF RUNX1 PF4 MRTFA KMT2A
6 regulation of hematopoietic stem cell differentiation GO:1902036 9.73 RUNX1 KMT2A GATA1
7 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.71 TP53 IL3 IL11 GATA1
8 positive regulation of macrophage differentiation GO:0045651 9.61 TRIB1 PF4
9 regulation of myeloid cell differentiation GO:0045637 9.61 RUNX1 CSF2
10 myeloid cell differentiation GO:0030099 9.61 RUNX1 GATA1 CSF2
11 cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:0097011 9.59 CSF2 AKT1
12 negative regulation of cell size GO:0045792 9.58 PTEN AKT1
13 primitive streak formation GO:0090009 9.58 SRF ETS2
14 megakaryocyte differentiation GO:0030219 9.57 IL11 GATA1
15 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.56 PF4 GATA1 CSF2 AKT1
16 response to fluid shear stress GO:0034405 9.55 CSF2 AKT1
17 regulation of cytokine-mediated signaling pathway GO:0001959 9.54 RUNX1 IL3
18 thrombopoietin-mediated signaling pathway GO:0038163 9.52 THPO RBM15
19 cellular response to decreased oxygen levels GO:0036294 9.51 PTEN AKT1
20 embryonic hemopoiesis GO:0035162 9.5 KMT2A IL3 GATA1
21 positive regulation of transcription via serum response element binding GO:0010735 9.49 SRF MRTFA
22 regulation of megakaryocyte differentiation GO:0045652 9.35 RUNX1 RBM15 PF4 KMT2A GATA1
23 cytokine-mediated signaling pathway GO:0019221 9.17 TP53 PF4 JAK3 IL3 IL11 CSF2

Molecular functions related to Acute Megakaryocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proximal promoter sequence-specific DNA binding GO:0000987 9.33 TP53 SRF GATA1
2 growth factor activity GO:0008083 9.26 THPO IL3 IL11 CSF2
3 cytokine activity GO:0005125 9.02 THPO PF4 IL3 IL11 CSF2

Sources for Acute Megakaryocytic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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