Acute Monoblastic Leukemia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ACT200 MIFTS: 41	Acute Monoblastic Leukemia Categories: Cancer diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Acute Monoblastic Leukemia

MalaCards integrated aliases for Acute Monoblastic Leukemia:

Name: Acute Monoblastic Leukemia ²⁰ ⁶ ⁷¹

Acute Monocytic Leukemia ²⁰ ⁷¹

M5b Acute Differentiated Monocytic Leukemia ⁷¹

Acute Monocytic/monoblastic Leukemia ⁷¹

Acute Myeloblastic Leukemia Type 5 ²⁰

Aml M5 ²⁰

Aml-M5 ²⁰

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

UMLS ⁷¹ C0023465 C0457334 C1318544 more

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Summaries for Acute Monoblastic Leukemia

GARD : ²⁰ The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 514DefinitionAcute monoblastic leukemia (AML-M5), is one of the most common subtypes of acute myeloid leukemia (AML; see this term) that is either comprised of more than 80% of monoblasts (AML-M5a) or 30-80% monoblasts with (pro)monocytic differentiation (AML-M5b). AML-M5 presents with asthenia, pallor, fever, and dizziness. Specific features of AML-M5 include hyperleukocytosis, propensity for extramedullary infiltrates, coagulation abnormalities including disseminated intravascular coagulation and neurological disorders. Leukemia cutis and gingival infiltration can also be seen. A characteristic translocation observed in AML-M5 is t(9;11).Visit the Orphanet disease page for more resources.

MalaCards based summary : Acute Monoblastic Leukemia, also known as acute monocytic leukemia, is related to leukemia, acute monocytic and acute leukemia. An important gene associated with Acute Monoblastic Leukemia is LPP (LIM Domain Containing Preferred Translocation Partner In Lipoma), and among its related pathways/superpathways are Cytokine Signaling in Immune system and JAK-STAT signaling pathway. The drugs Etoposide and Cytarabine have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone marrow and monocytes, and related phenotypes are neoplasm and respiratory system

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Related Diseases for Acute Monoblastic Leukemia

Diseases related to Acute Monoblastic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 288)

#	Related Disease	Score	Top Affiliating Genes
1	leukemia, acute monocytic	32.1	KMT2A IL6 CXCL8
2	acute leukemia	30.7	KMT2A IL7 EPO CSF2
3	monocytic leukemia	30.6	KMT2A IL6 CXCL8 CSF2
4	aspergillosis	30.4	IL6 CXCL8 CSF2
5	pancytopenia	30.3	KMT2A IL6 EPO CSF2
6	thrombocytosis	30.3	IL6 EPO CSF2
7	exanthem	30.2	IL6 CXCL8 CSF2
8	meningitis	30.1	IL6 CXCL8 CSF2
9	lung disease	30.0	IL6 CXCL8 CSF2 CD44
10	b-lymphoblastic leukemia/lymphoma	30.0	STK11 KMT2A IL7
11	myeloproliferative neoplasm	29.9	NF1 KMT2A EPO CSF2
12	neutropenia	29.9	IL6 EPO CXCL8 CSF2
13	leukemia, chronic myeloid	29.9	NF1 KMT2A EPO CSF2
14	essential thrombocythemia	29.8	IL6 EPO CXCL8 CSF2
15	myeloma, multiple	29.8	NF1 IL6 CXCL8 CSF2 CD44
16	leukemia, acute myeloid	29.7	NF1 LPP KMT2A IL7 IL6 EPO
17	acute promyelocytic leukemia	29.6	KMT2A IL6 CXCL8 CSF2 CD44
18	peripheral nervous system disease	29.5	NF1 IL6 EPO CXCL8 CSF2 CD44
19	myelodysplastic syndrome	29.5	NF1 KMT2A IL7 IL6 EPO CXCL8
20	lymphoma, non-hodgkin, familial	29.4	KMT2A IL7 IL6 CSF2 CD44
21	aplastic anemia	29.4	IL6 EPO CXCL8 CSF2
22	thrombocytopenia	29.4	IL7 IL6 EPO CXCL8 CSF2 CD44
23	adult acute monocytic leukemia	11.7
24	leukemia	10.6
25	myeloid sarcoma	10.5
26	sarcoma	10.4
27	disseminated intravascular coagulation	10.4
28	spindle cell sarcoma	10.4
29	chromosomal triplication	10.4
30	acute monoblastic/monocytic leukemia	10.4
31	neuroblastoma	10.3
32	myeloid leukemia	10.3
33	engraftment syndrome	10.3	CXCL8 CSF2
34	anemia of prematurity	10.3	EPO CSF2
35	myeloid and lymphoid neoplasms associated with pdgfra rearrangement	10.3	EPO CSF2
36	vibrio vulnificus infection	10.3	IL6 EPO
37	idiopathic anterior uveitis	10.3	IL6 CXCL8
38	streptococcal toxic-shock syndrome	10.3	IL6 CXCL8
39	acute transverse myelitis	10.3	IL6 CXCL8
40	acute gonococcal cervicitis	10.3	IL6 CXCL8
41	leukemia, acute lymphoblastic	10.3
42	histiocytosis	10.3
43	pfeiffer syndrome	10.2
44	chronic myelomonocytic leukemia	10.2
45	fuchs' heterochromic uveitis	10.2	IL6 CXCL8
46	suppurative periapical periodontitis	10.2	IL6 CXCL8
47	periapical periodontitis	10.2	IL6 CXCL8
48	ceftazidime allergy	10.2	IL7 EPO
49	bacterial conjunctivitis	10.2	IL6 CXCL8
50	tracheitis	10.2	IL6 CXCL8

Graphical network of the top 20 diseases related to Acute Monoblastic Leukemia:

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Symptoms & Phenotypes for Acute Monoblastic Leukemia

MGI Mouse Phenotypes related to Acute Monoblastic Leukemia:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	neoplasm	MP:0002006	9.43	CD44 CSF2 IL6 KMT2A NF1 STK11
2	respiratory system	MP:0005388	9.17	CD44 CSF2 EPO GPHN IL6 NF1

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Drugs & Therapeutics for Acute Monoblastic Leukemia

Drugs for Acute Monoblastic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Etoposide

Approved

Phase 2

33419-42-0

36462

Synonyms:

(−)-etoposide

(-)-Etoposide

121471-01-0

136598-18-0

201594-04-9

33419-42-0

35317-32-9

4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-b-D-glucopyranoside)

4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-beta-D-glucopyranoside)

4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-β-D-glucopyranoside)

4'-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-beta-D-glucopyranoside)

4'-Demethyl-epipodophyllotoxin 9-[4,6-O-(R)-ethylidene-beta-D-glucopyranoside

4-Demethylepipodophyllotoxin b-D-ethylideneglucoside

4-Demethylepipodophyllotoxin beta-D-ethylideneglucoside

4'-Demethylepipodophyllotoxin ethylidene-.beta.-D-glucoside

4-demethylepipodophyllotoxin β-D-ethylideneglucoside

4-Demethylepipodophyllotoxin β-D-ethylideneglucoside

4-Demethylepipodophyllotoxin-.beta.-D-ethylideneglucoside

4'-O-Demethyl-1-O-(4,6-O-ethylidene-beta-D-glucopyranosyl)epipodophyllotoxin

51854-34-3

76576-58-4

9-((4,6-O-Ethylidine-b-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-D)-1,3-dioxol-6(5ah)-one

9-((4,6-O-Ethylidine-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-d)-1,3-dioxol-6(5aH)-one

9-((4,6-O-Ethylidine-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-D)-1,3-dioxol-6(5ah)-one

9-((4,6-O-Ethylidine-β-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-D)-1,3-dioxol-6(5ah)-one

AB00438905

AC1L1FN8

AC1L1VT3

AC1L6246

AC1NR4OG

AC1O4WGG

AC1O7M1N

AC1Q47JJ

alpha-D-Glucopyranosyl isomer etoposide

Ambap33419-42-0

Baxter brand OF etoposide

Baxter oncology brand OF etoposide

Bio1_000489

Bio1_000978

Bio1_001467

BPBio1_000673

BRD-K37798499-001-02-5

Bristol myers brand OF etoposide

Bristol myers squibb brand OF etoposide

Bristol-myers brand OF etoposide

Bristol-myers squibb brand OF etoposide

BSPBio_000611

C01576

CCRIS 2392

Celltop

CHEBI:4911

CHEBI:588795

CHEMBL44657

CID11758093

CID284997

CID3310

CID36462

CID5284558

CID6419930

CID6610299

CPD000112002

D00125

DB00773

DEMETHY-EPIPODOPHYLLOTOXIN,ETHYLIDENE GLUCOSIDE,

Demethyl epipodophyllotoxin ethylidine glucoside

Demethyl Epipodophyllotoxin Ethylidine Glucoside

Demethyl-epiodophyllotoxin ethylidene glucoside

Demethylepipodophyllotoxin-beta-D-ethylideneglucoside

E0675

E1383_SIGMA

EINECS 251-509-1

Epipodophyllotoxin VP-16213

Epipodophyllotoxin, 4'-demethyl-, 4,6-O-ethylidene-.beta.-D-glucopyranoside

Epipodophyllotoxin, 4'-demethyl-, 4,6-O-ethylidene-beta-D-glucopyranoside

Epipodophyllotoxin, 4'-demethyl-, 4,6-O-ethylidene-beta-D-glucopyranoside (8CI)

Epipodophyllotoxin, 4'-demethyl-, 9-(4,6-O-ethylidene-.beta.-D-glucopyranoside)

Epipodophyllotoxin, 4'-demethyl-, 9-(4,6-O-ethylidene-beta-D-glucopyranoside)

Eposide

Eposin

Eposin, Vepesid, VP-16, Toposar, Etoposide

Eto gry

Eto-gry

Etomedac

ETOP

Etopol

Etopophos

Etopophos (phosphate salt)

Etopos

etoposide

Etoposide

Etoposide (JP15/USP/INN)

Etoposide (VP16)

Etoposide [USAN:INN:BAN:JAN]

Etoposide pierre fabre

Etoposide teva

Etoposide, (5a alpha)-isomer

Etoposide, (5a alpha,9 alpha)-isomer

Etoposide, (5S)-isomer

Etoposide, alpha D glucopyranosyl isomer

Etoposide, alpha-D-glucopyranosyl isomer

Etoposido

Etoposido [INN-Spanish]

Etoposido ferrer farma

Etoposidum

Etoposidum [INN-Latin]

Etosid

Exitop

Ferrer brand OF etoposide

Gry brand OF etoposide

HMS1569O13

HMS2052N05

HMS2089F14

HSDB 6517

I06-0248

KBioSS_002410

Lastet

Lemery brand OF etoposide

LS-1214

Medac brand OF etoposide

MLS000049957

MLS001074951

MLS001424283

MLS002153463

MLS002207239

MLS002222184

MolPort-003-983-431

MolPort-004-905-001

MolPort-004-955-161

NCGC00025056-02

NChemBio.2007.10-comp19

nchembio.573-comp8

nchembio873-comp2

NK 171

Novartis brand OF etoposide

NSC 141540

NSC141540

NSC-141540

Onkoposid

Onkoworks brand OF etoposide

Pharmachemie brand OF etoposide

Pierre fabre brand OF etoposide

Prasfarma brand OF etoposide

Prestwick_211

Prestwick0_000396

Prestwick1_000396

Prestwick2_000396

Prestwick3_000396

Riboposid

Ribosepharm brand OF etoposide

S1225_Selleck

SAM001246880

Sanfer brand OF etoposide

SMR000112002

SPBio_002532

ST056353

Tedec meiji brand OF etoposide

Teva brand OF etoposide

Teva, etoposide

Toposar

trans-Etoposide

UNII-6PLQ3CP4P3

Vepesid

VePesid

VePESID (TN)

Vepesid J

Vepeside

Vépéside sandoz

Vépéside-sandoz

VP 16

VP 16 (pharmaceutical)

VP 16213

VP 16-213

VP-16

VP-16-213

ZINC03830818

ZINC03938684

Zuyeyidal

Cytarabine

Approved, Investigational

Phase 2

147-94-4

6253

Synonyms:

(beta-D-Arabinofuranosyl)cytosine

1-.beta.-D-arabinofuranosyl-cytosine

147-94-4

1-Arabinofuranosylcytosine

1-b-D-Arabinofuranosylcytosine

1beta -Arabinofuranasylcytosine

1-beta -D-Arabinofaranosylcytosine

1-beta -D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone

1beta -D-Arabinofuranosylcytosine

1-beta -D-Arabinofuranosylcytosine

1beta -D-Arabinosylcytosine

1beta-Arabinofuranasylcytosine

1-beta-D-Arabinofaranosylcytosine

1-beta-D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone

1beta-D-Arabinofuranosylcytosine

1-beta-D-Arabinofuranosylcytosine

1-beta-D-Arabinofuranosyl-cytosine

1-beta-D-Arabinofuranosylcytosine, cytosine arabinoside

1-beta-D-Arabinofuranosylcytosine, Cytosine Arabinoside

1beta-D-Arabinosylcytosine

1-beta-D-Arabinosylcytosine

1-beta-D-Arabinosyl-cytosine

1-Β-D-arabinofuranosylcytosine

2(1H)-Pyrimidinone, 4-amino-1- -D-arabinofuranosyl- [CAS]

2(1H)-Pyrimidinone, 4-amino-1- -D-arabinofuranosyl

30399_FLUKA

4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidin

4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidin [Czech]

4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidine

4-Amino-1-b-D-arabinofuranosyl-2(1H)-pyrimidinone

4-Amino-1-b-D-arabinofuranosyl-2-(1H)-pyrimidinone

4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinon

4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinon [Czech]

4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone

4-amino-1-beta-D-arabinofuranosylpyrimidin-2(1H)-one

4-Amino-1-beta-D-arabinofuranosylpyrimidin-2(1H)-one

4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone

69-74-9 (hydrochloride)

AC-1075

AC1L1M4F

AC1Q52OJ

AI3-52329

Alexan

AR3

Ara C

Arabinocytidine

Arabinocytosine

Arabinofuranosylcytosine

Arabinoside C

Arabinoside, cytosine

Arabinosyl Cytosine

Arabinosylcytosine

Arabitin

AraC

Ara-C

Ara-C, Cytosine Arabinoside, Cytosar-U, Cytarabine

Aracytidine

Ara-Cytidine

Aracytin

Aracytine

Arafcyt

beta Ara C

beta -Arabinosylcytosine

beta -Cytosine arabinoside

beta -D-Arabinosylcytosine

beta-Ara c

beta-Ara C

beta-Arabinosylcytosine

beta-Cytosine arabinoside

Beta-cytosine arabinoside

beta-D-Arabinosylcytosine

BIDD:GT0371

BIDD:PXR0139

BTB15125

C02961

C1768_SIGMA

C2035

C9H13N3O5

CCRIS 913

CHEBI:28680

CHEMBL803

CHX 3311

CID6253

Citarabina

Citarabina [INN-Spanish]

CPD000449317

Cytarabin

Cytarabina

cytarabine

Cytarabine

Cytarabine (JP15/USP/INN)

CYTARABINE (SEE ALSO CYTARABINE HYDROCHLORIDE 69-74-9)

Cytarabine [USAN:INN:BAN:JAN]

Cytarabine hydrochloride

cytarabine liposome injection

Cytarabine liposome injection

Cytarabinoside

Cytarabinum

Cytarabinum [INN-Latin]

Cytarbel

Cytonal

Cytosar

Cytosar u

Cytosar-u

CytosarU

Cytosar-U

Cytosine 1-beta-D-arabinofuranoside

Cytosine arabinofuranoside

Cytosine arabinose

Cytosine arabinoside

Cytosine arabinoside (VAN)

Cytosine beta-D-arabinofuranoside

Cytosine beta-D-arabinofuranoside hydrochloride

Cytosine beta-D-arabinoside

Cytosine, beta -D-arabinoside

Cytosine, beta-D-arabinoside

Cytosine-1-b-D-arabinofuranoside

Cytosine-1-beta-D-arabinofuranoside

Cytosine-1-beta-D-arabinofuranoside hydrochloride

Cytosine-1-β-D-arabinofuranoside

Cytosinearabinoside

Cytosine-b-D-arabinofuranoside

Cytosine-beta -arabinoside

Cytosine-beta -D-arabinofuranoside

Cytosine-beta-arabinoside

Cytosine-beta-D-arabinofuranoside

cytosine-β-D-arabinofuranoside

Cytosine-β-D-arabinofuranoside

D00168

DB00987

Depocyt

Depocyt (liposomal)

Depocyt (TN)

Depocyte

DepoCyte

EINECS 205-705-9

Erpalfa

FT-0082880

HMS2051K19

HMS2090A18

HSDB 3049

Hydrochloride, cytarabine

Intrathecal (injected into the spinal fluid) DepoCyt

Intrathecal cytarabine (also known as ara-C)

Iretin

Lopac0_000316

LS-860

MLS000758310

MLS001066340

MolPort-001-792-509

NCGC00093356-03

NCGC00093356-04

NCGC00093356-05

NCI-C04728

NSC 287459

NSC287459

S1648_Selleck

SAM001247012

SMR000449317

Spongocytidine

SR-01000075773-3

Tarabine

TL8001048

U 19920A

U-19,920

U-19920

Udicil

UNII-04079A1RDZ

ZINC03795098

Idarubicin

Approved

Phase 2

58957-92-9

42890

Synonyms:

(1S,3S)-3-Acetyl-3,5,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydronaphthacen-1-yl 3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranoside

(1S,3S)-3-Acetyl-3,5,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydronaphthacen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside

(1S,3S)-3-acetyl-3,5,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydronaphthacen-1-yl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside

(1S,3S)-3-Acetyl-3,5,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydronaphthacen-1-yl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside

(1s,3s)-3-acetyl-3,5,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-|A-l-lyxo-hexopyranoside

(1S,3S)-3-acetyl-3,5,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside

(7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-8,10-dihydro-7H-tetracene-5,12-dione

(7S-cis)-9-Acetyl-7-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione

4 Demethoxydaunorubicin

4 Desmethoxydaunorubicin

4-Demethoxydaunomycin

4-Demethoxydaunorubicin

4-Desmethoxydaunorubicin

4-DMD

57852-57-0

57852-57-0 (HYDROCHLORIDE)

58957-92-9

AC1L28SA

AC1Q6JJ4

BRD-K69650333-001-01-1

C26H27NO9

CCRIS 5083

CHEBI:42068

CHEMBL1117

CID42890

D08062

DB01177

DM5

DMDR

EU-0100600

HMS2089D05

Hydrochloride, idarubicin

I 1656

I06-1097

I1656_SIGMA

Idamycin

Idamycin PFS

Idarubicin

IDARUBICIN

Idarubicin (INN)

Idarubicin [INN:BAN]

Idarubicin Aglycone

Idarubicin Hcl

Idarubicin Hcl Pfs

Idarubicin HCl PFS

idarubicin hydrochloride

Idarubicin hydrochloride

Idarubicin Hydrochloride

Idarubicina

Idarubicina [INN-Spanish]

Idarubicine

Idarubicine [INN-French]

Idarubicinum

Idarubicinum [INN-Latin]

IMI 30

IMI30

IMI-30

KBioSS_002388

Lopac0_000600

LS-94015

MLS000759470

NCGC00093976-01

NCGC00093976-02

NCGC00093976-03

NCGC00093976-04

NSC256439

NSC-256439

SMR000466355

UNII-ZRP63D75JW

Zavedos

Zavedos (TN)

Bortezomib

Approved, Investigational

Phase 2

179324-69-7

387447 93860

Synonyms:

[(1R)-3-methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)butyl]boronic acid

[(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid

179324-69-7

341, PS

AC1L8TUW

bortezomib

Bortezomib

Bortezomib (JAN/USAN/INN)

CHEBI:287372

CHEBI:41143

CHEMBL325041

CID387447

D03150

DB07475

DPBA

FT-0082488

I14-3268

LDP 341

LDP341

LDP-341

LPD 341

LPD-341

MLN341

MolPort-003-845-298

N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-Nalpha-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide

N-[(1R)-1-(DIHYDROXYBORYL)-3-methylbutyl]-N-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide

N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE

NCI60_029010

NSC681239

NSC-681239

PROSCRIPT BORONIC ACID

PS 341

PS-341

Pyz-Phe-boroLeu

S1013_Selleck

SBB071337

Velcade

Velcade (TN)

Velcade, MG-341, PS-341, Bortezomib

Antibiotics, Antitubercular

Phase 2

Immunosuppressive Agents

Phase 2

Etoposide phosphate

Phase 2

Anti-Infective Agents

Phase 2

Antiviral Agents

Phase 2

Antimetabolites

Phase 2

Immunologic Factors

Phase 2

Anti-Bacterial Agents

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Phase II Pilot Study of Bortezomib (PS-341, Velcade) Combined With Reinduction Chemotherapy in Children and Young Adults With Recurrent, Refractory or Secondary Acute Myeloid Leukemia	Completed	NCT00666588	Phase 2	idarubicin;cytarabine;bortezomib;etoposide
2	A Phase 1, Multicenter, Open-Label, Dose-Escalation and Expansion Study of Intravenously Administered IO-202 in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML) and Chronic Myelomonocytic Leukemia (CMML)	Recruiting	NCT04372433	Phase 1	IO-202 Dose Escalation;IO-202 Dose Expansion
3	Observational - Rapid Identification of Leukemia Stem Cells Associated With AML1-ETO and Inv(16) Through Characterization of Oncogene-Induced Changes in Cell-Surface Antigen Profiles on Hematopoietic Stem Cells	Completed	NCT01642121

Search NIH Clinical Center for Acute Monoblastic Leukemia

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Genetic Tests for Acute Monoblastic Leukemia

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Anatomical Context for Acute Monoblastic Leukemia

MalaCards organs/tissues related to Acute Monoblastic Leukemia:

⁴⁰

Myeloid, Bone Marrow, Monocytes, Endothelial, T Cells, Skin, Spinal Cord

Sources

Publications for Acute Monoblastic Leukemia

Articles related to Acute Monoblastic Leukemia:

(show top 50) (show all 1239)

#	Title	Authors	PMID	Year
1	The effects of malvidin on oxidative stress parameters and inflammatory cytokines in LPS-induced human THP-1 cells. ⁶¹	Bastin A...Akbari H	32914418	2021
2	Cytotoxic effect of CLL‑1 CAR‑T cell immunotherapy with PD‑1 silencing on relapsed/refractory acute myeloid leukemia. ⁶¹	Lin G...Wu D	33495835	2021
3	Bone Marrow Necrosis in Acute Monoblastic Leukemia. ⁶¹	Terao T...Matsue K	33596359	2021
4	Identification of fucosylated haptoglobin-producing cells in pancreatic cancer tissue and its molecular mechanism. ⁶¹	Ito N...Miyoshi E	33523362	2021
5	Effect of gingival mesenchymal stem cell-derived exosomes on inflammatory macrophages in a high-lipid microenvironment. ⁶¹	Zhang Y...Xu Q	33582592	2021
6	IL-1 signaling pathway molecules as key markers in childhood asthma. ⁶¹	Wei W...Hao C	33025692	2021
7	Identification of HLA-A*0201-restricted CTL Epitopes for MLAA-34-specific Immunotherapy for Acute Monocytic Leukemia. ⁶¹	Bai J...Zhang W	33596023	2021
8	Integrated analysis of microRNA and transcription factors in the bone marrow of patients with acute monocytic leukemia. ⁶¹	Lin XC...Zhang HT	33281961	2021
9	HEMOPHAGOCYTOSIS BY BLASTS IN A CHILD WITH ACUTE MONOCYTIC LEUKEMIA AFTER CHEMOTHERAPY. ⁶¹	Farias MG...Daudt LE	32638943	2021
10	Discovery of Venturicidin Congeners and Identification of the Biosynthetic Gene Cluster from Streptomyces sp. NRRL S-4. ⁶¹	Li H...Sun P	33356258	2021
11	Chemistry, oxidative stability and bioactivity of oil extracted from Rosa rugosa (Thunb.) seeds by supercritical carbon dioxide. ⁶¹	Grajzer M...Prescha A	32738538	2021
12	[Efficacy and Prognosis of Allogeneic Hematopoietic Stem Cell Transplantation for Acute Monocytic Leukemia Patients]. ⁶¹	Pan WY...Huang YX	33283711	2020
13	A case of rhinocerebral mucormycosis with brain abscess drained by endoscopic endonasal skull base surgery. ⁶¹	Uraguchi K...Nishizaki K	33083212	2020
14	Laboratory Soft X-Ray Microscopy with an Integrated Visible-Light Microscope-Correlative Workflow for Faster 3D Cell Imaging. ⁶¹	Dehlinger A...Kanngie?er B	33023699	2020
15	Effect of Essential Oils on the Release of TNF-α and CCL2 by LPS-Stimulated THP‑1 Cells. ⁶¹	Miguel MG...Figueiredo AC	33379375	2020
16	Acute Monoblastic Leukemia with Erythrophagocytosis and Absence of KAT6A Rearrangement ⁶¹	Sanchez CM...de Castro JMG	32519830	2020
17	Widespread Skin Infiltration of Leukemia Cutis on 18F-FDG PET/CT. ⁶¹	Zheng J...Miao W	32558715	2020
18	Relapsed acute monocytic leukemia presenting as histiocytic morphology. ⁶¹	Liu B...Li T	32954486	2020
19	LINC00449 regulates the proliferation and invasion of acute monocytic leukemia and predicts favorable prognosis. ⁶¹	Shi Y...Zheng Z	31960456	2020
20	Acute monocytic leukemia presenting as generalized lymphadenopathy and skin rash in a toddler: highlighting the clinicopathologic mimics. ⁶¹	Jain A...Varma N	33095510	2020
21	Diterpenoids from Cephalotaxus fortunei var. alpina and their cytotoxic activity. ⁶¹	Li Y...Hua H	32891003	2020
22	Transient receptor potential ankyrin 1 contributes to the ATP-elicited oxidative stress and inflammation in THP-1-derived macrophage. ⁶¹	Tian C...Li Z	32627113	2020
23	Adult Langerhans cell histiocytosis presenting with multisystem involvement and sarcomatoid features: a case report. ⁶¹	Aguirre LE...Alencar A	32979930	2020
24	Effects of DNA Methylation on Leukemia Cell Proliferation. ⁶¹	Kanda T...Kawakami Y	32902233	2020
25	LILRB4-targeting Antibody-Drug Conjugates for the Treatment of Acute Myeloid Leukemia. ⁶¹	Anami Y...Tsuchikama K	32879051	2020
26	Targeting Membrane HDM-2 by PNC-27 Induces Necrosis in Leukemia Cells But Not in Normal Hematopoietic Cells. ⁶¹	Thadi A...Bowne WB	32878773	2020
27	Lissajous scanning magnetic particle imaging as a multifunctional platform for magnetic hyperthermia therapy. ⁶¹	Wells J...Wiekhorst F	32869808	2020
28	Microfluidic Separation of Blood Cells Based on the Negative Dielectrophoresis Operated by Three Dimensional Microband Electrodes. ⁶¹	Yasukawa T...Suzuki M	32878221	2020
29	Bioactive flavonoids from plant extract of Pyrethrum pulchrum and its acute toxicity. ⁶¹	Erdenetsogt U...Dagvadorj E	32799581	2020
30	Role of growth hormone signaling pathways in the development of atherosclerosis. ⁶¹	Ishikawa M...Yoshino G	32721858	2020
31	Acute monoblastic leukemia in a feline leukemia virus-negative cat. ⁶¹	Tagawa M...Miyahara K	32448817	2020
32	[Polarization of human acute monocytic leukemia THP-1 cells-derived macprophages induced by Nippostrongylus brasiliensis proteins in vitro]. ⁶¹	Wu XM...Cao J	32935510	2020
33	Identification of a t(X;17)(q28;q21) generating a KANSL1-MTCP1 gene fusion leading to dysregulated expression of MTCP1 in acute myeloid leukemia. ⁶¹	Li SX...Chen B	32167630	2020
34	Importance of distinguishing the promonocyte in leukemia. ⁶¹	Krause JR...Bredeweg A	33100557	2020
35	Prognostic stratification of molecularly and clinically distinct subgroup in children with acute monocytic leukemia. ⁶¹	Liu LP...Zhu XF	32216042	2020
36	PFKFB4 is critical for the survival of acute monocytic leukemia cells. ⁶¹	Wang G...Dong S	32299611	2020
37	CD47 decline in pancreatic islet cells promotes macrophage-mediated phagocytosis in type I diabetes. ⁶¹	Zhang J...Guo ZG	32547698	2020
38	[Clinical Characteristics and Prognostic Influencing Factors of Adult AML Patients with MLL Rearrangement]. ⁶¹	Wang T...Xu LR	32552935	2020
39	Infectivity and Drug Susceptibility Profiling of Different Leishmania-Host Cell Combinations. ⁶¹	Baek KH...No JH	32443883	2020
40	Triiodothyronine Attenuates Silica-Induced Oxidative Stress, Inflammation, and Apoptosis via Thyroid Hormone Receptor α in Differentiated THP-1 Macrophages. ⁶¹	Gan S...Chen W	32223187	2020
41	Distinct anti-proliferative effects of herbal melanin on human acute monocytic leukemia THP-1 cells and embryonic kidney HEK293 cells. ⁶¹	El-Obeid A...Matou-Nasri S	32448225	2020
42	Rare Case of Diffuse Large B-Cell Lymphoma Mimicking Acute Monocytic Leukemia, Associated with Complex Karyotype. ⁶¹	Chen X...Yin J	32581033	2020
43	Cytotoxic and antiproliferative activities of amphibian (anuran) skin extracts on human acute monocytic leukemia cells. ⁶¹	Spinelli R...Siano AS	31982457	2020
44	Identification and functional study of immortalized mouse thymic epithelial cells. ⁶¹	Shen JM...Gao JL	32107001	2020
45	The P2X7 receptor mediates NLRP3-dependent IL-1β secretion and promotes phagocytosis in the macrophage response to Treponema pallidum. ⁶¹	Xu SL...Lin LR	32151957	2020
46	GP73 facilitates hepatitis B virus replication by repressing the NF-κB signaling pathway. ⁶¹	Liu L...Liu Z	32077512	2020
47	Endometrial stromal cells treated by tumor necrosis factor-α stimulate macrophages polarized toward M2 via interleukin-6 and monocyte chemoattractant protein-1. ⁶¹	Li MZ...Nie MF	31930665	2020
48	Transient Receptor Potential Ankyrin 1 Contributes to Lysophosphatidylcholine-Induced Intracellular Calcium Regulation and THP-1-Derived Macrophage Activation. ⁶¹	Tian C...Li Z	31820013	2020
49	[Pulmonary infiltration of acute monoblastic leukemia diagnosed by transbronchial lung biopsy]. ⁶¹	Harada N...Nakamae H	32023598	2020
50	Effects of green tea epigallocatechin-3-gallate on transcription factors regulating expression of FLT3. ⁶¹	Thi Kim Ly B...Chi HT	32277682	2020

Sources

Genes for Acute Monoblastic Leukemia

Genes related to Acute Monoblastic Leukemia (0 elite genes):

(show all 15)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	LPP	LIM Domain Containing Preferred Translocation Partner In Lipoma	Protein Coding	8.19	GeneCards inferred via : Disorders (show sections)
2	NF1	Neurofibromin 1	Protein Coding	7.69	GeneCards inferred via : Variants (show sections)
3	CD44	CD44 Molecule (Indian Blood Group)	Protein Coding	7.36	GeneCards inferred via : Publications (show sections)
4	STK11	Serine/Threonine Kinase 11	Protein Coding	7.34	GeneCards inferred via : Variants (show sections)
5	CSF2	Colony Stimulating Factor 2	Protein Coding	7.02	GeneCards inferred via : Publications (show sections)
6	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	7.02	GeneCards inferred via : Publications (show sections)
7	EPO	Erythropoietin	Protein Coding	7.02	GeneCards inferred via : Publications (show sections)
8	GPHN	Gephyrin	Protein Coding	7.02	GeneCards inferred via : Publications (show sections)
9	IL6	Interleukin 6	Protein Coding	7.02	GeneCards inferred via : Publications (show sections)
10	IL7	Interleukin 7	Protein Coding	7.02	GeneCards inferred via : Publications (show sections)
11	KMT2A	Lysine Methyltransferase 2A	Protein Coding	7.02	GeneCards inferred via : Publications (show sections)
12	LOC107963948	BCR-ABL Micro-Breakpoint Cluster Region	Biological Region	7.02	GeneCards inferred via : Publications (show sections)
13	LOC107980440	ABL Breakpoint Recombination Region	Biological Region	7.02	GeneCards inferred via : Publications (show sections)
14	LOC108449888	PATRR22 Recombination Region	Biological Region	7.02	GeneCards inferred via : Publications (show sections)
15	LOC108449897	PATRR11 Recombination Region	Biological Region	7.02	GeneCards inferred via : Publications (show sections)

Sources

Variations for Acute Monoblastic Leukemia

ClinVar genetic disease variations for Acute Monoblastic Leukemia:

⁶

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	GRCh37 Pos	GRCh38 Pos
1	NF1	NM_000267.3(NF1):c.1588G>A (p.Val530Ile)	SNV	Uncertain significance	141369	rs145191978	17:29546083-29546083	17:31219065-31219065
2	NF1	NM_000267.3(NF1):c.2747A>G (p.Asn916Ser)	SNV	Uncertain significance	229977	rs765043916	17:29556380-29556380	17:31229362-31229362
3	STK11	NM_000455.4(STK11):c.970C>G (p.Pro324Ala)	SNV	Uncertain significance	127710	rs549474196	19:1223033-1223033	19:1223034-1223034

Sources

Expression for Acute Monoblastic Leukemia

Search GEO for disease gene expression data for Acute Monoblastic Leukemia.

Sources

Pathways for Acute Monoblastic Leukemia

Pathways related to Acute Monoblastic Leukemia according to GeneCards Suite gene sharing:

(show all 19)

#	Super pathways	Score	Top Affiliating Genes
1	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.16	NF1 IL7 IL6 CXCL8 CSF2 CD44
2	JAK-STAT signaling pathway ³⁶ Show member pathways B-Cell Development ⁶³ IL-7 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶⁴ Interleukin-19, 20, 22, 24 ⁶⁵ Jak/STAT Signaling Pathway ⁶⁴ Type III interferon signaling ¹	12.22	IL7 IL6 EPO CSF2
3	Transcriptional misregulation in cancer ³⁶	12.04	KMT2A IL6 CXCL8 CSF2
4	Amoebiasis ³⁶	11.75	IL6 CXCL8 CSF2
5	Rheumatoid arthritis ³⁶	11.7	IL6 CXCL8 CSF2
6	Cytokine production by Th17 cells in CF (Mouse model) ²³ Show member pathways Cytokine production by Th17 cells in CF ²³	11.69	IL6 CXCL8 CSF2
7	Glucocorticoid receptor regulatory network ¹	11.63	IL6 CXCL8 CSF2
8	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²³	11.49	IL6 CXCL8 CSF2
9	Senescence and Autophagy in Cancer ¹	11.48	KMT2A IL6 CXCL8 CD44
10	Lung fibrosis ¹	11.47	IL6 CXCL8 CSF2
11	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.42	IL7 IL6 EPO CSF2 CD44
12	ATF-2 transcription factor network ¹	11.39	NF1 IL6 CXCL8
13	Hepatitis C and Hepatocellular Carcinoma ¹	11.32	IL6 CXCL8 CD44
14	Interleukin-10 signaling ⁶⁵	11.27	IL6 CXCL8 CSF2
15	Hematopoietic Stem Cell Differentiation ¹	11.23	IL6 EPO CSF2
16	Syndecan-2-mediated signaling events ¹	11.02	NF1 CXCL8 CSF2
17	Hematopoietic cell lineage ³⁶	11.02	IL7 IL6 EPO CSF2 CD44
18	Cytokines and Inflammatory Response ¹	10.9	IL7 IL6 CSF2
19	Overview of nanoparticle effects ¹	10.86	IL6 CXCL8

Sources

GO Terms for Acute Monoblastic Leukemia

Biological processes related to Acute Monoblastic Leukemia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine-mediated signaling pathway	GO:0019221	9.26	IL7 IL6 CXCL8 CSF2
2	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	8.8	IL6 EPO CSF2

Molecular functions related to Acute Monoblastic Leukemia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	9.02	IL7 IL6 EPO CXCL8 CSF2

Sources

Sources for Acute Monoblastic Leukemia

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia