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MCID: ACT200
MIFTS: 46

Acute Monoblastic Leukemia

Categories: Rare diseases, Blood diseases, Cancer diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Acute Monoblastic Leukemia

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MalaCards integrated aliases for Acute Monoblastic Leukemia:

Name: Acute Monoblastic Leukemia 53 59 73
Acute Monocytic Leukemia 53 59 73
Aml M5 53 59
M5b Acute Differentiated Monocytic Leukemia 73
Acute Monocytic/monoblastic Leukemia 73
Acute Myeloblastic Leukemia Type 5 53
Aml-M5 53

Characteristics:

Orphanet epidemiological data:

59
acute monoblastic leukemia
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: Childhood;

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Blood diseases
See all MalaCards categories (disease lists)
ICD10: 34
Orphanet: 59  
Rare haematological diseases


External Ids:

Orphanet 59 ORPHA514
UMLS via Orphanet 74 C1318544 C0457334 C0023465
ICD10 via Orphanet 34 C92.7
MESH via Orphanet 45 D007948
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Summaries for Acute Monoblastic Leukemia

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NIH Rare Diseases : 53 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 514Disease definitionAcute monoblastic leukemia (AML-M5), is one of the most common subtypes of acute myeloid leukemia (AML; see this term) that is either comprised of more than 80% of monoblasts (AML-M5a) or 30-80% monoblasts with (pro)monocytic differentiation (AML-M5b). AML-M5 presents with asthenia, pallor, fever, and dizziness. Specific features of AML-M5 include hyperleukocytosis, propensity for extramedullary infiltrates, coagulation abnormalities including disseminated intravascular coagulation and neurological disorders. Leukemia cutis and gingival infiltration can also be seen. A characteristic translocation observed in AML-M5 is t(9;11).Visit the Orphanet disease page for more resources.

MalaCards based summary : Acute Monoblastic Leukemia, also known as acute monocytic leukemia, is related to monocytic leukemia and myeloma, multiple. An important gene associated with Acute Monoblastic Leukemia is LPP (LIM Domain Containing Preferred Translocation Partner In Lipoma), and among its related pathways/superpathways are Pathways in cancer and Regulation of IFNA signaling. The drugs Lenograstim and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include myeloid, monocytes and bone.

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Related Diseases for Acute Monoblastic Leukemia

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Diseases related to Acute Monoblastic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 monocytic leukemia 29.5 CSF2 CXCL8 IL6 KMT2A
2 myeloma, multiple 28.9 CD44 CSF2 CXCL8 EPO IL6
3 adult acute monocytic leukemia 12.6
4 leukemia, acute monocytic 11.2
5 leukemia 10.7
6 engraftment syndrome 10.7 CSF2 CXCL8
7 felty syndrome 10.6 CSF2 CXCL8
8 cyclic neutropenia 10.6 CSF2 CXCL8
9 natural killer cell leukemia 10.6 EPO IL7
10 recurrent corneal erosion 10.6 CXCL8 IL6
11 bagassosis 10.6 CXCL8 IL6
12 acute transverse myelitis 10.5 CXCL8 IL6
13 streptococcal toxic-shock syndrome 10.5 CXCL8 IL6
14 denture stomatitis 10.5 CXCL8 IL6
15 funisitis 10.5 CXCL8 IL6
16 b-cell growth factor 10.5 IL6 IL7
17 vaginal disease 10.5 CXCL8 IL6
18 vibrio vulnificus infection 10.5 EPO IL6
19 pharyngitis 10.5 CSF2 CXCL8
20 louse-borne relapsing fever 10.5 CXCL8 IL6
21 neutrophilia, hereditary 10.4 CSF2 IL6
22 preterm premature rupture of the membranes 10.4 CXCL8 IL6
23 ascaris lumbricoides infection 10.4 IL6 IL7
24 endometrial disease 10.4 CXCL8 IL6
25 arteriovenous fistula 10.4 EPO IL6
26 transverse myelitis 10.4 CXCL8 IL6
27 vaginitis 10.4 CXCL8 IL6
28 necrotizing fasciitis 10.4 CXCL8 IL6
29 bacteriuria 10.4 CXCL8 IL6
30 poems syndrome 10.4 EPO IL6
31 cowpox 10.4 CXCL8 IL6
32 anemia of prematurity 10.3 CSF2 EPO
33 acute cystitis 10.3 CXCL8 IL6
34 sarcoma 10.2
35 cytomegalovirus infection 10.2 CXCL8 IL6
36 papillary conjunctivitis 10.2 CXCL8 IL6 IL7
37 myeloid sarcoma 10.2
38 radiculopathy 10.2 CXCL8 IL6 IL7
39 pulpitis 10.2 CXCL8 IL6
40 capillary leak syndrome 10.2 CSF2 CXCL8 IL6
41 meconium aspiration syndrome 10.2 CSF2 CXCL8 IL6
42 mastitis 10.2 CSF2 CXCL8 IL6
43 respiratory system disease 10.2 CSF2 CXCL8 IL6
44 kaposi sarcoma 10.1 CSF2 CXCL8 IL6
45 emanuel syndrome 10.1 LOC108449888 LOC108449897
46 acute pyelonephritis 10.1 CXCL8 IL6
47 thrombocytosis 10.1 CSF2 EPO IL6
48 immune system disease 10.0 CSF2 EPO IL6
49 periventricular leukomalacia 10.0 EPO IL6
50 leukemia, chronic myeloid 10.0 CSF2 EPO KMT2A

Graphical network of the top 20 diseases related to Acute Monoblastic Leukemia:



Diseases related to Acute Monoblastic Leukemia
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Symptoms & Phenotypes for Acute Monoblastic Leukemia

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Drugs & Therapeutics for Acute Monoblastic Leukemia

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Drugs for Acute Monoblastic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 217)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 135968-09-1
2
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
3
Amsacrine Approved, Investigational Phase 3 51264-14-3 2179
4
Mesna Approved, Investigational Phase 3 3375-50-6 598
5
Cytarabine Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 147-94-4 6253
6
Clofarabine Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 123318-82-1 119182
7
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
8
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 50-18-0, 6055-19-2 2907
9
Busulfan Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 55-98-1 2478
10
Idarubicin Approved Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58957-92-9 42890
11
Mitoxantrone Approved, Investigational Phase 3,Phase 2,Phase 1 65271-80-9 4212
12
Daunorubicin Approved Phase 3,Phase 2,Phase 1 20830-81-3 30323
13
Thioguanine Approved Phase 3,Phase 1 154-42-7 2723601
14
Aldesleukin Approved Phase 3,Phase 1,Phase 2 85898-30-2, 110942-02-4
15
alemtuzumab Approved, Investigational Phase 2, Phase 3,Phase 1 216503-57-0
16
Fludarabine Approved Phase 3,Phase 2,Phase 1,Not Applicable 21679-14-1, 75607-67-9 30751
17
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
18
Hydroxyurea Approved Phase 3 127-07-1 3657
19
Methotrexate Approved Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
20
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1 50-02-2 5743
21
Melphalan Approved Phase 2, Phase 3,Phase 3,Phase 1 148-82-3 4053 460612
22
Azacitidine Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 320-67-2 9444
23
Decitabine Approved, Investigational Phase 3,Phase 2,Phase 1 2353-33-5 451668
24
Carmustine Approved, Investigational Phase 3 154-93-8 2578
25
Arsenic trioxide Approved, Investigational Phase 2, Phase 3,Phase 1 1327-53-3 518740
26
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
27
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
28
Cyproheptadine Approved Phase 3 129-03-3 2913
29
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
30
Tretinoin Approved, Investigational, Nutraceutical Phase 3,Phase 2,Phase 1 302-79-4 5538 444795
31
leucovorin Approved, Nutraceutical Phase 3,Phase 2,Phase 1 58-05-9 143 6006
32
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1 59-30-3 6037
33
tipifarnib Investigational Phase 2, Phase 3,Phase 3,Phase 1 192185-72-1 159324
34 Staurosporine Experimental Phase 3,Phase 1 62996-74-1
35
Butyric Acid Experimental, Investigational Phase 3 107-92-6 264
36 Interleukin-2 Phase 3,Phase 1,Phase 2
37 Analgesics Phase 3,Phase 2,Phase 1
38 Alkylating Agents Phase 3,Phase 2,Phase 1,Not Applicable
39 Gemtuzumab Phase 2, Phase 3,Phase 3,Phase 1
40 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
41 Dermatologic Agents Phase 3,Phase 2,Phase 1
42 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2,Phase 1
43 Vaccines Phase 3,Phase 1
44 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
45 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
46 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
47 Antibodies Phase 3,Phase 2
48 Immunoglobulins Phase 3,Phase 2
49 Antibodies, Monoclonal Phase 3,Phase 2
50 Etoposide phosphate Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 183)
# Name Status NCT ID Phase Drugs
1 Vaccine Therapy and GM-CSF in Treating Patients With Acute Myeloid Leukemia in Remission Unknown status NCT00454168 Phase 3
2 Combination Chemotherapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Acute Myelogenous Leukemia Unknown status NCT00002549 Phase 3 busulfan;cyclophosphamide;cytarabine;daunorubicin hydrochloride;etoposide;idarubicin;mesna;mitoxantrone hydrochloride
3 Combination Chemotherapy With or Without Monoclonal Antibody Therapy in Treating Patients With Refractory or Relapsed Acute Myelogenous Leukemia Unknown status NCT00006045 Phase 3 cytarabine;etoposide;mitoxantrone hydrochloride
4 Gemtuzumab Ozogamicin in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia Unknown status NCT00091234 Phase 2, Phase 3 gemtuzumab ozogamicin
5 Combination Chemotherapy, Interleukin-2, and Peripheral Stem Cell Transplant in Treating Patients With Acute Myeloid Leukemia Unknown status NCT00004128 Phase 3 busulfan;cyclophosphamide;cytarabine;daunorubicin hydrochloride;etoposide
6 Combination Chemotherapy, Biological Therapy, and Bone Marrow Transplantation in Treating Patients With Acute Myeloid Leukemia Unknown status NCT00002658 Phase 3 amsacrine;cyclophosphamide;cytarabine;daunorubicin hydrochloride;etoposide;idarubicin;mitoxantrone hydrochloride;thioguanine;tretinoin
7 Combination Chemotherapy With or Without PSC 833, Peripheral Stem Cell Transplantation, and/or Interleukin-2 in Treating Patients With Acute Myeloid Leukemia Completed NCT00006363 Phase 3 cytarabine;daunorubicin hydrochloride;etoposide;valspodar;busulfan
8 Combination Chemotherapy With or Without Valspodar in Treating Patients With Previously Untreated Acute Myeloid Leukemia Completed NCT00003190 Phase 3 cytarabine;daunorubicin hydrochloride;etoposide;valspodar
9 Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome Completed NCT00002798 Phase 3 asparaginase;daunorubicin hydrochloride;fludarabine phosphate;therapeutic hydrocortisone;cytarabine;idarubicin;dexamethasone;thioguanine;etoposide;methotrexate;cyclophosphamide;busulfan
10 Combination Chemotherapy in Treating Young Patients With Down Syndrome and Acute Myeloid Leukemia or Myelodysplastic Syndromes Completed NCT00369317 Phase 3 asparaginase;daunorubicin hydrochloride;cytarabine;thioguanine;etoposide
11 Combination Chemotherapy With or Without Gemtuzumab in Treating Young Patients With Newly Diagnosed Acute Myeloid Leukemia Completed NCT00372593 Phase 3 asparaginase;cytarabine;daunorubicin hydrochloride;etoposide;gemtuzumab ozogamicin;mitoxantrone hydrochloride
12 Combination Chemotherapy With or Without Filgrastim and/or Tretinoin in Treating Patients With Acute Myeloid Leukemia Completed NCT00005863 Phase 3 cytarabine;daunorubicin hydrochloride;etoposide;fludarabine phosphate;tretinoin
13 Cytarabine and Daunorubicin With or Without Gemtuzumab Ozogamicin in Treating Older Patients With Acute Myeloid Leukemia or Myelodysplastic Syndromes Completed NCT00121303 Phase 3 cytarabine;daunorubicin hydrochloride;gemtuzumab ozogamicin
14 Combination Chemotherapy With or Without Gemtuzumab Ozogamicin or Tipifarnib in Treating Patients With Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndromes Completed NCT00454480 Phase 2, Phase 3 arsenic trioxide;azacitidine;busulfan;clofarabine;cytarabine;daunorubicin hydrochloride;fludarabine phosphate;gemtuzumab ozogamicin;melphalan;tipifarnib
15 Chemotherapy With or Without Gemtuzumab Ozogamicin in Treating Older Patients With Acute Myeloid Leukemia Completed NCT00052299 Phase 3 cytarabine;etoposide;gemtuzumab ozogamicin;idarubicin;mitoxantrone hydrochloride
16 Daunorubicin & Cytarabine +/- Zosuquidar inTreating Older Patients With Newly Diagnosed Acute Myeloid Leukemia or Refractory Anemia Completed NCT00046930 Phase 3 cytarabine;daunorubicin hydrochloride;zosuquidar trihydrochloride;Placebo
17 S0106 Cytarabine and Daunorubicin w/ or w/o Gemtuzumab Followed By HD Cytarabine and Either Gemtuzumab or Nothing in de Novo AML Completed NCT00085709 Phase 3 gemtuzumab ozogamicin;Cytosine arabinoside;Daunomycin
18 Cytarabine With or Without VNP40101M in Treating Patients With Relapsed Acute Myeloid Leukemia Completed NCT00112554 Phase 3 cytarabine;laromustine
19 Combination Chemotherapy With or Without G-CSF in Treating Older Patients With Acute Myeloid Leukemia Completed NCT00002719 Phase 3 amsacrine;carmustine;cytarabine;etoposide;idarubicin;mitoxantrone hydrochloride
20 Intensive Compared With Nonintensive Chemotherapy in Treating Older Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome Completed NCT00005823 Phase 3 cytarabine;daunorubicin hydrochloride;etoposide;hydroxyurea;idarubicin;mitoxantrone hydrochloride;thioguanine;tretinoin;valspodar
21 flt3L in Treating Patients With Acute Myeloid Leukemia Completed NCT00006223 Phase 3
22 Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome Completed NCT00002517 Phase 3 cytarabine;daunorubicin hydrochloride;dexamethasone;etoposide;idarubicin;mitoxantrone hydrochloride;thioguanine
23 Chemotherapy in Treating Children With Down Syndrome and Myeloproliferative Disorder, Acute Myelogenous Leukemia, or Myelodysplastic Syndrome Completed NCT00003593 Phase 3 asparaginase;cytarabine;daunorubicin hydrochloride;methotrexate;therapeutic hydrocortisone;thioguanine
24 Tipifarnib in Treating Patients With Acute Myeloid Leukemia in Remission Completed NCT00093470 Phase 3 Tipifarnib
25 High Dose Chemotherapy, Peripheral Stem Cell Transplantation, and Interleukin-2 in Treating Patients With Acute Myeloid Leukemia Completed NCT00002945 Phase 3 cyclophosphamide;cytarabine;etoposide;idarubicin;melphalan
26 Caspofungin Acetate or Fluconazole in Preventing Invasive Fungal Infections in Patients With Acute Myeloid Leukemia Who Are Undergoing Chemotherapy Active, not recruiting NCT01307579 Phase 3 caspofungin acetate;fluconazole
27 Clofarabine or Daunorubicin Hydrochloride and Cytarabine Followed By Decitabine or Observation in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia Active, not recruiting NCT02085408 Phase 3 clofarabine;daunorubicin hydrochloride;cytarabine;decitabine
28 Daunorubicin, Cytarabine, and Midostaurin in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Active, not recruiting NCT00651261 Phase 3 cytarabine;daunorubicin;midostaurin;dexamethasone acetate
29 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
30 Lenalidomide in Treating Older Patients With Acute Myeloid Leukemia Who Have Undergone Stem Cell Transplant Unknown status NCT02038153 Phase 1, Phase 2 Lenalidomide
31 Combination Chemotherapy Plus Biological Therapy in Treating Patients With Acute Myelogenous Leukemia Unknown status NCT00003405 Phase 2 amifostine trihydrate;bromodeoxyuridine;cytarabine;idarubicin;idoxuridine;isotretinoin;mitoxantrone hydrochloride
32 Combination Chemotherapy in Treating Patients With Relapsed Acute Myelogenous Leukemia Unknown status NCT00003758 Phase 2 cytarabine;idarubicin
33 Clofarabine, Cytarabine, and Idarubicin in Treating Patients With Intermediate-Risk or High-Risk Acute Myeloid Leukemia or High-Risk Myelodysplasia Unknown status NCT00838240 Phase 1, Phase 2 clofarabine;cytarabine;idarubicin
34 VNP40101M Followed by Cytarabine in Treating Older Patients With Acute Myeloid Leukemia Unknown status NCT00354276 Phase 2 cytarabine;laromustine
35 Bexarotene and GM-CSF in Treating Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia Unknown status NCT00425477 Phase 2 bexarotene
36 Monoclonal Antibody in Treating Patients With Acute Myelogenous Leukemia Unknown status NCT00006084 Phase 2
37 Bortezomib and Combination Chemotherapy in Treating Younger Patients With Recurrent, Refractory, or Secondary Acute Myeloid Leukemia Completed NCT00666588 Phase 2 idarubicin;cytarabine;bortezomib;etoposide
38 High-Dose Busulfan and High-Dose Cyclophosphamide Followed By Donor Bone Marrow Transplant in Treating Patients With Leukemia, Myelodysplastic Syndrome, Multiple Myeloma, or Recurrent Hodgkin or Non-Hodgkin Lymphoma Completed NCT01177371 Phase 2 busulfan;cyclophosphamide;methylprednisolone;methotrexate;cyclosporine
39 Donor Umbilical Cord Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies Completed NCT01093586 Phase 2 busulfan;cyclophosphamide;anti-thymocyte globulin;methylprednisolone;cyclosporine;mycophenolate mofetil
40 Tipifarnib in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia Completed NCT00027872 Phase 2 tipifarnib
41 Cytarabine With or Without SCH 900776 in Treating Adult Patients With Relapsed Acute Myeloid Leukemia Completed NCT01870596 Phase 2 Cytarabine;CHK1 Inhibitor SCH 900776
42 Tipifarnib in Treating Older Patients With Acute Myeloid Leukemia Completed NCT01361464 Phase 2 Tipifarnib
43 Choline Magnesium Trisalicylate and Combination Chemotherapy in Treating Patients With Acute Myeloid Leukemia Completed NCT02144675 Phase 2 choline magnesium trisalicylate;idarubicin;cytarabine
44 Alvocidib, Cytarabine, and Mitoxantrone Hydrochloride or Cytarabine and Daunorubicin Hydrochloride in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Completed NCT01349972 Phase 2 alvocidib;daunorubicin hydrochloride;mitoxantrone hydrochloride;cytarabine
45 AKT Inhibitor MK-2206 in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia Completed NCT01253447 Phase 2 Akt inhibitor MK2206
46 Early Discharge and Outpatients Care in Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia Previously Treated With Intensive Chemotherapy Completed NCT01235572 Phase 2
47 Vorinostat, Azacitidine, and Gemtuzumab Ozogamicin for Older Patients With Relapsed or Refractory AML Completed NCT00895934 Phase 1, Phase 2 vorinostat;gemtuzumab ozogamicin;azacitidine
48 Comparing Three Different Combination Chemotherapy Regimens in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia Completed NCT00634244 Phase 2 alvocidib;mitoxantrone hydrochloride;carboplatin;cytarabine;sirolimus;etoposide;topotecan hydrochloride
49 Alvocidib, Cytarabine, and Mitoxantrone in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Completed NCT00795002 Phase 2 alvocidib;mitoxantrone hydrochloride;cytarabine
50 Bortezomib, Daunorubicin, and Cytarabine in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia Completed NCT00742625 Phase 1, Phase 2 daunorubicin hydrochloride;cytarabine;bortezomib

Search NIH Clinical Center for Acute Monoblastic Leukemia

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Genetic Tests for Acute Monoblastic Leukemia

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Anatomical Context for Acute Monoblastic Leukemia

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MalaCards organs/tissues related to Acute Monoblastic Leukemia:

41
Myeloid, Monocytes, Bone, Bone Marrow, Prostate, Lung, B Cells
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Publications for Acute Monoblastic Leukemia

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Articles related to Acute Monoblastic Leukemia:

(show top 50) (show all 59)
# Title Authors Year
1
Clonal dynamics in a case of acute monoblastic leukemia that later developed myeloproliferative neoplasm. ( 29417354 )
2018
2
mRNA expression profiling of histone modifying enzymes in pediatric acute monoblastic leukemia. ( 29442054 )
2017
3
Erythrophagocytosis by blasts in a case of de novo acute monoblastic leukemia with rare but characteristic t(8;16). ( 28272065 )
2017
4
Central hypothyroidism in a pediatric case of primary acute monoblastic leukemia with central nervous system infiltration: A case report. ( 28658145 )
2017
5
Acute monoblastic leukemia presenting with striking periorbital and periauricular infiltration. ( 28642361 )
2017
6
Acute monoblastic leukemia presented with multiple granulocytic sarcoma nodules. ( 27094724 )
2016
7
Acute monoblastic leukemia with abnormal eosinophils and inversion (16): A rare entity. ( 26960652 )
2016
8
Isolated central nervous system primary acute monoblastic leukemia presenting as papilledema. ( 27569601 )
2016
9
Spontaneous remission of aleukemic cutaneous myeloid sarcoma followed by crisis of acute monoblastic leukemia. ( 26661142 )
2016
10
Lineage switch with t(6;11)(q27;q23) from T-cell lymphoblastic lymphoma to acute monoblastic leukemia at relapse. ( 27268298 )
2016
11
Pseudo Chediak-Higashi anomaly in acute monoblastic leukemia. ( 27884836 )
2016
12
Transfusion medicine illustrated. Blast cell fragments mimic platelets in acute monoblastic leukemia. ( 26074175 )
2015
13
Infantile Acute Monoblastic Leukemia with MLL Gene Rearrangements. ( 25548462 )
2015
14
Concurrent Acute Monoblastic Leukemia and Multiple Myeloma in a 66-Year-Old Chemotherapy-Naive Woman. ( 29147380 )
2014
15
[Acute monoblastic leukemia with MLL/AF9 rearrangement which developed 18 months after myeloid sarcoma onset]. ( 24452147 )
2013
16
Hemophagocytic syndrome in children with acute monoblastic leukemia-another cause of fever of unknown origin. ( 23975227 )
2013
17
CD44 activation enhances acute monoblastic leukemia cell survival via Mcl-1 upregulation. ( 21993315 )
2012
18
Acute monoblastic leukemia that switched lineage at relapse to acute lymphoblastic leukemia: a case report. ( 22217491 )
2012
19
MLL-ELL fusion gene in two infants with acute monoblastic leukemia and myeloid sarcoma. ( 22149207 )
2012
20
A rare cryptic and complex rearrangement leading to MLL-MLLT10 gene fusion masked by del(10)(p12) in a child with acute monoblastic leukemia (AML-M5). ( 22261229 )
2012
21
[Development of acute myeloid leukemia from donor cells after allogeneic peripheral blood stem cell transplantation in a female patient with acute monoblastic leukemia]. ( 21675261 )
2011
22
Successful Administration of Recombinant Human Soluble Thrombomodulin I+ (Recomodulin) for Disseminated Intravascular Coagulation during Induction Chemotherapy in an Elderly Patient with Acute Monoblastic Leukemia Involving the t(9;11)(p22;q23) MLL/AF9 Translocation. ( 22937304 )
2011
23
Segmental amplification of MLL gene associated with high expression of AURKA and AURKB genes in a case of acute monoblastic leukemia with complex karyotype. ( 20303016 )
2010
24
Polyradiculoneuritis revealing an acute monoblastic leukemia 5. ( 21293744 )
2010
25
Successful treatment of Aspergillus liver abscesses in a patient with acute monoblastic leukemia using combination antifungal therapy including micafungin as a key drug. ( 20352380 )
2010
26
Acute monoblastic leukemia with abnormal granules and disseminated intravascular coagulation: diagnostic pitfalls. ( 19806662 )
2009
27
A complex 1;19;11 translocation involving the MLL gene in a patient with congenital acute monoblastic leukemia identified by molecular and cytogenetic techniques. ( 19107484 )
2009
28
Monoblastic sarcoma cutis preceding acute monoblastic leukemia. ( 19051330 )
2009
29
Chemotherapy-induced acral erythema in a pediatric patient with acute monoblastic leukemia. ( 18432504 )
2008
30
Donor cell-derived acute monoblastic leukemia involving MLL gene translocation in an adult patient who received umbilical cord blood transplantation. ( 17982506 )
2008
31
Contribution of GM-CSF and IL-8 to the CD44-induced differentiation of acute monoblastic leukemia. ( 17914409 )
2008
32
Acute monoblastic leukemia in a FeLV-positive cat. ( 18296895 )
2008
33
Tetrasomy 8 in a patient with acute monoblastic leukemia. ( 18728374 )
2008
34
Dramatic response of acute monoblastic leukemia to a single dose of docetaxel. ( 18297537 )
2008
35
A novel AF9 breakpoint in MLL-AF9-positive acute monoblastic leukemia. ( 18000862 )
2008
36
Acute monoblastic leukemia with t(10;11)(p12;q23) presenting with pulmonary involvement: a case report and literature review. ( 18556867 )
2008
37
Trisomy 22 as sole cytogenetic abnormality in acute monoblastic leukemia (M5b). ( 16875946 )
2006
38
[Acute monoblastic leukemia with tetrasomy 8]. ( 16986717 )
2006
39
Simultaneous presentation of acute monoblastic leukemia and mantle cell lymphoma: case report and review of the literature. ( 16263586 )
2005
40
Rearrangement of MLL in a patient with congenital acute monoblastic leukemia and granulocytic sarcoma associated with a t(1;11)(p36;q23) translocation. ( 15621793 )
2005
41
Duchenne muscular dystrophy-rhabdomyosarcoma, ichthyosis vulgaris/acute monoblastic leukemia: association of rare genetic disorders and childhood malignant diseases. ( 12116087 )
2002
42
Erythropoietin-dependent transformation of myelodysplastic syndrome to acute monoblastic leukemia. ( 11719396 )
2001
43
Acute monoblastic leukemia with t(8;16): a distinct clinicopathologic entity; report of a case and review of the literature. ( 11279628 )
2001
44
p230 does not always predict a mild clinical course in myeloid malignancies: e19a2 bcr/abl fusion transcript with additional chromosome abnormalities in a patient with acute monoblastic leukemia (M5a). ( 11255282 )
2001
45
t(11;14)(q23;q24) generates an MLL-human gephyrin fusion gene along with a de facto truncated MLL in acute monoblastic leukemia. ( 11289145 )
2001
46
Progression from myelodysplastic syndrome with monosomy 7 to acute monoblastic leukemia with MLL gene rearrangement. ( 9594441 )
1998
47
Characterization of a novel malignant B cell line with t(14;18) and t(4;11) established from a patient with acute monoblastic leukemia. ( 9293903 )
1997
48
Polyneuropathy associated with acute monoblastic leukemia: a case report. ( 9068211 )
1996
49
Ultrastructural localization of myeloperoxidase activity in acute monoblastic leukemia. ( 8161732 )
1993
50
Cutis verticis gyrata secondary to acute monoblastic leukemia. ( 8103266 )
1993
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Variations for Acute Monoblastic Leukemia

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Expression for Acute Monoblastic Leukemia

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Search GEO for disease gene expression data for Acute Monoblastic Leukemia.
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Pathways for Acute Monoblastic Leukemia

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Pathways related to Acute Monoblastic Leukemia according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Pathways in cancer 37
12.6 CXCL8 EPO IL6 IL7
2
Regulation of IFNA signaling 66
Show member pathways
 12.25 CSF2 CXCL8 EPO IL6 IL7
3
Transcriptional misregulation in cancer 37
11.97 CSF2 CXCL8 IL6 KMT2A
4
Amoebiasis 37
11.72 CSF2 CXCL8 IL6
5
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.69 CSF2 CXCL8 IL6
6
Rheumatoid arthritis 37
11.67 CSF2 CXCL8 IL6
7
Salmonella infection (KEGG) 37
11.63 CSF2 CXCL8 IL6
8
Glucocorticoid receptor regulatory network 1
11.6 CSF2 CXCL8 IL6
9
Senescence and Autophagy in Cancer 1
11.48 CD44 CXCL8 IL6 KMT2A
10
Lung fibrosis 1
11.47 CSF2 CXCL8 IL6
11
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.45 CSF2 CXCL8 IL6
12
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.42 CD44 CSF2 EPO IL6 IL7
13
Hepatitis C and Hepatocellular Carcinoma 1
11.34 CD44 CXCL8 IL6
14
Interleukin-10 signaling 66
11.3 CSF2 CXCL8 IL6
15
Hematopoietic Stem Cell Differentiation 1
11.23 CSF2 EPO IL6
16
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.13 CXCL8 IL6
17
Syndecan-2-mediated signaling events 1
11.11 CSF2 CXCL8
18
Development and heterogeneity of the ILC family 1
11.09 IL6 IL7
19
Hematopoietic cell lineage 37
11.01 CD44 CSF2 EPO IL6 IL7
20
Cytokines and Inflammatory Response 1
10.97 CSF2 IL6 IL7
21
Overview of nanoparticle effects 1
10.85 CXCL8 IL6
Sources

GO Terms for Acute Monoblastic Leukemia

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Biological processes related to Acute Monoblastic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.78 CSF2 EPO IL6 IL7
2 immune response GO:0006955 9.71 CSF2 CXCL8 IL6 IL7
3 cellular response to fibroblast growth factor stimulus GO:0044344 9.46 CD44 CXCL8
4 cytokine-mediated signaling pathway GO:0019221 9.46 CSF2 CXCL8 IL6 IL7
5 homeostasis of number of cells within a tissue GO:0048873 9.43 IL7 KMT2A
6 cellular response to lipopolysaccharide GO:0071222 9.43 CSF2 CXCL8 IL6
7 positive regulation of leukocyte chemotaxis GO:0002690 9.37 CXCL8 IL6
8 positive regulation of chemokine production GO:0032722 9.32 IL6 IL7
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.13 CSF2 EPO IL6
10 regulation of signaling receptor activity GO:0010469 9.02 CSF2 CXCL8 EPO IL6 IL7

Molecular functions related to Acute Monoblastic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 CSF2 IL6 IL7
2 cytokine activity GO:0005125 9.02 CSF2 CXCL8 EPO IL6 IL7
Sources

Sources for Acute Monoblastic Leukemia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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