MCID: ACT200
MIFTS: 41

Acute Monoblastic Leukemia

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Acute Monoblastic Leukemia

MalaCards integrated aliases for Acute Monoblastic Leukemia:

Name: Acute Monoblastic Leukemia 20 6 71
Acute Monocytic Leukemia 20 71
M5b Acute Differentiated Monocytic Leukemia 71
Acute Monocytic/monoblastic Leukemia 71
Acute Myeloblastic Leukemia Type 5 20
Aml M5 20
Aml-M5 20

Classifications:



External Ids:

UMLS 71 C0023465 C0457334 C1318544 more

Summaries for Acute Monoblastic Leukemia

GARD : 20 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 514DefinitionAcute monoblastic leukemia (AML-M5), is one of the most common subtypes of acute myeloid leukemia (AML; see this term) that is either comprised of more than 80% of monoblasts (AML-M5a) or 30-80% monoblasts with (pro)monocytic differentiation (AML-M5b). AML-M5 presents with asthenia, pallor, fever, and dizziness. Specific features of AML-M5 include hyperleukocytosis, propensity for extramedullary infiltrates, coagulation abnormalities including disseminated intravascular coagulation and neurological disorders. Leukemia cutis and gingival infiltration can also be seen. A characteristic translocation observed in AML-M5 is t(9;11).Visit the Orphanet disease page for more resources.

MalaCards based summary : Acute Monoblastic Leukemia, also known as acute monocytic leukemia, is related to leukemia, acute monocytic and acute leukemia. An important gene associated with Acute Monoblastic Leukemia is LPP (LIM Domain Containing Preferred Translocation Partner In Lipoma), and among its related pathways/superpathways are Cytokine Signaling in Immune system and JAK-STAT signaling pathway. The drugs Etoposide and Cytarabine have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone marrow and monocytes, and related phenotypes are neoplasm and respiratory system

Related Diseases for Acute Monoblastic Leukemia

Diseases related to Acute Monoblastic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 288)
# Related Disease Score Top Affiliating Genes
1 leukemia, acute monocytic 32.1 KMT2A IL6 CXCL8
2 acute leukemia 30.7 KMT2A IL7 EPO CSF2
3 monocytic leukemia 30.6 KMT2A IL6 CXCL8 CSF2
4 aspergillosis 30.4 IL6 CXCL8 CSF2
5 pancytopenia 30.3 KMT2A IL6 EPO CSF2
6 thrombocytosis 30.3 IL6 EPO CSF2
7 exanthem 30.2 IL6 CXCL8 CSF2
8 meningitis 30.1 IL6 CXCL8 CSF2
9 lung disease 30.0 IL6 CXCL8 CSF2 CD44
10 b-lymphoblastic leukemia/lymphoma 30.0 STK11 KMT2A IL7
11 myeloproliferative neoplasm 29.9 NF1 KMT2A EPO CSF2
12 neutropenia 29.9 IL6 EPO CXCL8 CSF2
13 leukemia, chronic myeloid 29.9 NF1 KMT2A EPO CSF2
14 essential thrombocythemia 29.8 IL6 EPO CXCL8 CSF2
15 myeloma, multiple 29.8 NF1 IL6 CXCL8 CSF2 CD44
16 leukemia, acute myeloid 29.7 NF1 LPP KMT2A IL7 IL6 EPO
17 acute promyelocytic leukemia 29.6 KMT2A IL6 CXCL8 CSF2 CD44
18 peripheral nervous system disease 29.5 NF1 IL6 EPO CXCL8 CSF2 CD44
19 myelodysplastic syndrome 29.5 NF1 KMT2A IL7 IL6 EPO CXCL8
20 lymphoma, non-hodgkin, familial 29.4 KMT2A IL7 IL6 CSF2 CD44
21 aplastic anemia 29.4 IL6 EPO CXCL8 CSF2
22 thrombocytopenia 29.4 IL7 IL6 EPO CXCL8 CSF2 CD44
23 adult acute monocytic leukemia 11.7
24 leukemia 10.6
25 myeloid sarcoma 10.5
26 sarcoma 10.4
27 disseminated intravascular coagulation 10.4
28 spindle cell sarcoma 10.4
29 chromosomal triplication 10.4
30 acute monoblastic/monocytic leukemia 10.4
31 neuroblastoma 10.3
32 myeloid leukemia 10.3
33 engraftment syndrome 10.3 CXCL8 CSF2
34 anemia of prematurity 10.3 EPO CSF2
35 myeloid and lymphoid neoplasms associated with pdgfra rearrangement 10.3 EPO CSF2
36 vibrio vulnificus infection 10.3 IL6 EPO
37 idiopathic anterior uveitis 10.3 IL6 CXCL8
38 streptococcal toxic-shock syndrome 10.3 IL6 CXCL8
39 acute transverse myelitis 10.3 IL6 CXCL8
40 acute gonococcal cervicitis 10.3 IL6 CXCL8
41 leukemia, acute lymphoblastic 10.3
42 histiocytosis 10.3
43 pfeiffer syndrome 10.2
44 chronic myelomonocytic leukemia 10.2
45 fuchs' heterochromic uveitis 10.2 IL6 CXCL8
46 suppurative periapical periodontitis 10.2 IL6 CXCL8
47 periapical periodontitis 10.2 IL6 CXCL8
48 ceftazidime allergy 10.2 IL7 EPO
49 bacterial conjunctivitis 10.2 IL6 CXCL8
50 tracheitis 10.2 IL6 CXCL8

Graphical network of the top 20 diseases related to Acute Monoblastic Leukemia:



Diseases related to Acute Monoblastic Leukemia

Symptoms & Phenotypes for Acute Monoblastic Leukemia

MGI Mouse Phenotypes related to Acute Monoblastic Leukemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.43 CD44 CSF2 IL6 KMT2A NF1 STK11
2 respiratory system MP:0005388 9.17 CD44 CSF2 EPO GPHN IL6 NF1

Drugs & Therapeutics for Acute Monoblastic Leukemia

Drugs for Acute Monoblastic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 2 33419-42-0 36462
2
Cytarabine Approved, Investigational Phase 2 147-94-4 6253
3
Idarubicin Approved Phase 2 58957-92-9 42890
4
Bortezomib Approved, Investigational Phase 2 179324-69-7 387447 93860
5 Antibiotics, Antitubercular Phase 2
6 Immunosuppressive Agents Phase 2
7 Etoposide phosphate Phase 2
8 Anti-Infective Agents Phase 2
9 Antiviral Agents Phase 2
10 Antimetabolites Phase 2
11 Immunologic Factors Phase 2
12 Anti-Bacterial Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Pilot Study of Bortezomib (PS-341, Velcade) Combined With Reinduction Chemotherapy in Children and Young Adults With Recurrent, Refractory or Secondary Acute Myeloid Leukemia Completed NCT00666588 Phase 2 idarubicin;cytarabine;bortezomib;etoposide
2 A Phase 1, Multicenter, Open-Label, Dose-Escalation and Expansion Study of Intravenously Administered IO-202 in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML) and Chronic Myelomonocytic Leukemia (CMML) Recruiting NCT04372433 Phase 1 IO-202 Dose Escalation;IO-202 Dose Expansion
3 Observational - Rapid Identification of Leukemia Stem Cells Associated With AML1-ETO and Inv(16) Through Characterization of Oncogene-Induced Changes in Cell-Surface Antigen Profiles on Hematopoietic Stem Cells Completed NCT01642121

Search NIH Clinical Center for Acute Monoblastic Leukemia

Genetic Tests for Acute Monoblastic Leukemia

Anatomical Context for Acute Monoblastic Leukemia

MalaCards organs/tissues related to Acute Monoblastic Leukemia:

40
Myeloid, Bone Marrow, Monocytes, Endothelial, T Cells, Skin, Spinal Cord

Publications for Acute Monoblastic Leukemia

Articles related to Acute Monoblastic Leukemia:

(show top 50) (show all 1239)
# Title Authors PMID Year
1
The effects of malvidin on oxidative stress parameters and inflammatory cytokines in LPS-induced human THP-1 cells. 61
32914418 2021
2
Cytotoxic effect of CLL‑1 CAR‑T cell immunotherapy with PD‑1 silencing on relapsed/refractory acute myeloid leukemia. 61
33495835 2021
3
Bone Marrow Necrosis in Acute Monoblastic Leukemia. 61
33596359 2021
4
Identification of fucosylated haptoglobin-producing cells in pancreatic cancer tissue and its molecular mechanism. 61
33523362 2021
5
Effect of gingival mesenchymal stem cell-derived exosomes on inflammatory macrophages in a high-lipid microenvironment. 61
33582592 2021
6
IL-1 signaling pathway molecules as key markers in childhood asthma. 61
33025692 2021
7
Identification of HLA-A*0201-restricted CTL Epitopes for MLAA-34-specific Immunotherapy for Acute Monocytic Leukemia. 61
33596023 2021
8
Integrated analysis of microRNA and transcription factors in the bone marrow of patients with acute monocytic leukemia. 61
33281961 2021
9
HEMOPHAGOCYTOSIS BY BLASTS IN A CHILD WITH ACUTE MONOCYTIC LEUKEMIA AFTER CHEMOTHERAPY. 61
32638943 2021
10
Discovery of Venturicidin Congeners and Identification of the Biosynthetic Gene Cluster from Streptomyces sp. NRRL S-4. 61
33356258 2021
11
Chemistry, oxidative stability and bioactivity of oil extracted from Rosa rugosa (Thunb.) seeds by supercritical carbon dioxide. 61
32738538 2021
12
[Efficacy and Prognosis of Allogeneic Hematopoietic Stem Cell Transplantation for Acute Monocytic Leukemia Patients]. 61
33283711 2020
13
A case of rhinocerebral mucormycosis with brain abscess drained by endoscopic endonasal skull base surgery. 61
33083212 2020
14
Laboratory Soft X-Ray Microscopy with an Integrated Visible-Light Microscope-Correlative Workflow for Faster 3D Cell Imaging. 61
33023699 2020
15
Effect of Essential Oils on the Release of TNF-α and CCL2 by LPS-Stimulated THP‑1 Cells. 61
33379375 2020
16
Acute Monoblastic Leukemia with Erythrophagocytosis and Absence of KAT6A Rearrangement 61
32519830 2020
17
Widespread Skin Infiltration of Leukemia Cutis on 18F-FDG PET/CT. 61
32558715 2020
18
Relapsed acute monocytic leukemia presenting as histiocytic morphology. 61
32954486 2020
19
LINC00449 regulates the proliferation and invasion of acute monocytic leukemia and predicts favorable prognosis. 61
31960456 2020
20
Acute monocytic leukemia presenting as generalized lymphadenopathy and skin rash in a toddler: highlighting the clinicopathologic mimics. 61
33095510 2020
21
Diterpenoids from Cephalotaxus fortunei var. alpina and their cytotoxic activity. 61
32891003 2020
22
Transient receptor potential ankyrin 1 contributes to the ATP-elicited oxidative stress and inflammation in THP-1-derived macrophage. 61
32627113 2020
23
Adult Langerhans cell histiocytosis presenting with multisystem involvement and sarcomatoid features: a case report. 61
32979930 2020
24
Effects of DNA Methylation on Leukemia Cell Proliferation. 61
32902233 2020
25
LILRB4-targeting Antibody-Drug Conjugates for the Treatment of Acute Myeloid Leukemia. 61
32879051 2020
26
Targeting Membrane HDM-2 by PNC-27 Induces Necrosis in Leukemia Cells But Not in Normal Hematopoietic Cells. 61
32878773 2020
27
Lissajous scanning magnetic particle imaging as a multifunctional platform for magnetic hyperthermia therapy. 61
32869808 2020
28
Microfluidic Separation of Blood Cells Based on the Negative Dielectrophoresis Operated by Three Dimensional Microband Electrodes. 61
32878221 2020
29
Bioactive flavonoids from plant extract of Pyrethrum pulchrum and its acute toxicity. 61
32799581 2020
30
Role of growth hormone signaling pathways in the development of atherosclerosis. 61
32721858 2020
31
Acute monoblastic leukemia in a feline leukemia virus-negative cat. 61
32448817 2020
32
[Polarization of human acute monocytic leukemia THP-1 cells-derived macprophages induced by Nippostrongylus brasiliensis proteins in vitro]. 61
32935510 2020
33
Identification of a t(X;17)(q28;q21) generating a KANSL1-MTCP1 gene fusion leading to dysregulated expression of MTCP1 in acute myeloid leukemia. 61
32167630 2020
34
Importance of distinguishing the promonocyte in leukemia. 61
33100557 2020
35
Prognostic stratification of molecularly and clinically distinct subgroup in children with acute monocytic leukemia. 61
32216042 2020
36
PFKFB4 is critical for the survival of acute monocytic leukemia cells. 61
32299611 2020
37
CD47 decline in pancreatic islet cells promotes macrophage-mediated phagocytosis in type I diabetes. 61
32547698 2020
38
[Clinical Characteristics and Prognostic Influencing Factors of Adult AML Patients with MLL Rearrangement]. 61
32552935 2020
39
Infectivity and Drug Susceptibility Profiling of Different Leishmania-Host Cell Combinations. 61
32443883 2020
40
Triiodothyronine Attenuates Silica-Induced Oxidative Stress, Inflammation, and Apoptosis via Thyroid Hormone Receptor α in Differentiated THP-1 Macrophages. 61
32223187 2020
41
Distinct anti-proliferative effects of herbal melanin on human acute monocytic leukemia THP-1 cells and embryonic kidney HEK293 cells. 61
32448225 2020
42
Rare Case of Diffuse Large B-Cell Lymphoma Mimicking Acute Monocytic Leukemia, Associated with Complex Karyotype. 61
32581033 2020
43
Cytotoxic and antiproliferative activities of amphibian (anuran) skin extracts on human acute monocytic leukemia cells. 61
31982457 2020
44
Identification and functional study of immortalized mouse thymic epithelial cells. 61
32107001 2020
45
The P2X7 receptor mediates NLRP3-dependent IL-1β secretion and promotes phagocytosis in the macrophage response to Treponema pallidum. 61
32151957 2020
46
GP73 facilitates hepatitis B virus replication by repressing the NF-κB signaling pathway. 61
32077512 2020
47
Endometrial stromal cells treated by tumor necrosis factor-α stimulate macrophages polarized toward M2 via interleukin-6 and monocyte chemoattractant protein-1. 61
31930665 2020
48
Transient Receptor Potential Ankyrin 1 Contributes to Lysophosphatidylcholine-Induced Intracellular Calcium Regulation and THP-1-Derived Macrophage Activation. 61
31820013 2020
49
[Pulmonary infiltration of acute monoblastic leukemia diagnosed by transbronchial lung biopsy]. 61
32023598 2020
50
Effects of green tea epigallocatechin-3-gallate on transcription factors regulating expression of FLT3. 61
32277682 2020

Variations for Acute Monoblastic Leukemia

ClinVar genetic disease variations for Acute Monoblastic Leukemia:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 NF1 NM_000267.3(NF1):c.1588G>A (p.Val530Ile) SNV Uncertain significance 141369 rs145191978 17:29546083-29546083 17:31219065-31219065
2 NF1 NM_000267.3(NF1):c.2747A>G (p.Asn916Ser) SNV Uncertain significance 229977 rs765043916 17:29556380-29556380 17:31229362-31229362
3 STK11 NM_000455.4(STK11):c.970C>G (p.Pro324Ala) SNV Uncertain significance 127710 rs549474196 19:1223033-1223033 19:1223034-1223034

Expression for Acute Monoblastic Leukemia

Search GEO for disease gene expression data for Acute Monoblastic Leukemia.

Pathways for Acute Monoblastic Leukemia

Pathways related to Acute Monoblastic Leukemia according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.16 NF1 IL7 IL6 CXCL8 CSF2 CD44
2
Show member pathways
12.22 IL7 IL6 EPO CSF2
3 12.04 KMT2A IL6 CXCL8 CSF2
4 11.75 IL6 CXCL8 CSF2
5 11.7 IL6 CXCL8 CSF2
6
Show member pathways
11.69 IL6 CXCL8 CSF2
7 11.63 IL6 CXCL8 CSF2
8
Show member pathways
11.49 IL6 CXCL8 CSF2
9 11.48 KMT2A IL6 CXCL8 CD44
10 11.47 IL6 CXCL8 CSF2
11 11.42 IL7 IL6 EPO CSF2 CD44
12 11.39 NF1 IL6 CXCL8
13 11.32 IL6 CXCL8 CD44
14 11.27 IL6 CXCL8 CSF2
15 11.23 IL6 EPO CSF2
16 11.02 NF1 CXCL8 CSF2
17 11.02 IL7 IL6 EPO CSF2 CD44
18 10.9 IL7 IL6 CSF2
19 10.86 IL6 CXCL8

GO Terms for Acute Monoblastic Leukemia

Biological processes related to Acute Monoblastic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.26 IL7 IL6 CXCL8 CSF2
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 8.8 IL6 EPO CSF2

Molecular functions related to Acute Monoblastic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 IL7 IL6 EPO CXCL8 CSF2

Sources for Acute Monoblastic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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