MCID: ACT114
MIFTS: 32

Acute Myeloblastic Leukemia Without Maturation

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Acute Myeloblastic Leukemia Without Maturation

MalaCards integrated aliases for Acute Myeloblastic Leukemia Without Maturation:

Name: Acute Myeloblastic Leukemia Without Maturation 53 59
Acute Myeloblastic Leukemia M1 53 59
Aml M1 53 59
Acute Myeloblastic Leukemia Type 1 53

Characteristics:

Orphanet epidemiological data:

59

Classifications:



External Ids:

Orphanet 59 ORPHA98833
UMLS via Orphanet 74 C0026998
ICD10 via Orphanet 34 C92.0
ICD10 33 C92.0

Summaries for Acute Myeloblastic Leukemia Without Maturation

NIH Rare Diseases : 53 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 98833Disease definitionAcute myeloblastic leukemia without maturation is a rare, acute myeloid leukemia characterized by no significant myeloid maturation and more than 90% blast cells in the non-erythroid population. Various degrees of anemia, thrombocytopenia, or pancytopenia are present. Frequent clinical manifestations include fatigue, fever, bleeding disorders, and organomegaly, especially hepatosplenomegaly.Visit the Orphanet disease page for more resources.

MalaCards based summary : Acute Myeloblastic Leukemia Without Maturation, also known as acute myeloblastic leukemia m1, is related to leukemia and acute myeloblastic leukemia with maturation. An important gene associated with Acute Myeloblastic Leukemia Without Maturation is NPM1 (Nucleophosmin 1), and among its related pathways/superpathways is Tyrosine Kinases / Adaptors. The drugs Cyclophosphamide and Lenograstim have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow.

Wikipedia : 76 Acute myeloblastic leukemia without maturation is a quickly progressing disease in which too many... more...

Related Diseases for Acute Myeloblastic Leukemia Without Maturation

Diseases related to Acute Myeloblastic Leukemia Without Maturation via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 leukemia 30.3 FLT3 NPM1
2 acute myeloblastic leukemia with maturation 9.9 FLT3 NPM1
3 cytogenetically normal acute myeloid leukemia 9.9 FLT3 NPM1
4 myeloid leukemia 9.9 FLT3 NPM1
5 aleukemic leukemia cutis 9.9 FLT3 NPM1
6 myeloid sarcoma 9.9 FLT3 NPM1
7 fanconi anemia, complementation group a 9.8 FLT3 NPM1
8 wilms tumor 1 9.8 FLT3 NPM1
9 hematologic cancer 9.8 FLT3 NPM1
10 acute promyelocytic leukemia 9.8 FLT3 NPM1
11 leukemia, acute myeloid 9.8 FLT3 NPM1
12 myelodysplastic syndrome 9.7 FLT3 NPM1

Graphical network of the top 20 diseases related to Acute Myeloblastic Leukemia Without Maturation:



Diseases related to Acute Myeloblastic Leukemia Without Maturation

Symptoms & Phenotypes for Acute Myeloblastic Leukemia Without Maturation

Drugs & Therapeutics for Acute Myeloblastic Leukemia Without Maturation

Drugs for Acute Myeloblastic Leukemia Without Maturation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 203)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 6055-19-2, 50-18-0 2907
2
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 135968-09-1
3
Thiotepa Approved, Investigational Phase 4,Phase 2,Phase 1 52-24-4 5453
4 Antineoplastic Agents, Alkylating Phase 4,Phase 3,Phase 2,Phase 1
5 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1
6 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
7 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
8 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
9 Antilymphocyte Serum Phase 4,Phase 2
10
Busulfan Approved, Investigational Phase 3,Phase 2,Phase 1 55-98-1 2478
11
Cytarabine Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 147-94-4 6253
12
Daunorubicin Approved Phase 3,Phase 2,Phase 1 20830-81-3 30323
13
Mitoxantrone Approved, Investigational Phase 3,Phase 2,Phase 1 65271-80-9 4212
14
Mesna Approved, Investigational Phase 3 3375-50-6 598
15
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
16
Idarubicin Approved Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58957-92-9 42890
17
Amsacrine Approved, Investigational Phase 3 51264-14-3 2179
18
Thioguanine Approved Phase 3,Phase 1 154-42-7 2723601
19
Aldesleukin Approved Phase 3,Phase 1,Phase 2 85898-30-2, 110942-02-4
20
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
21
Clofarabine Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 123318-82-1 119182
22
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
23
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
24
Fludarabine Approved Phase 3,Phase 2,Phase 1,Not Applicable 75607-67-9, 21679-14-1 30751
25
leucovorin Approved Phase 3,Phase 2,Phase 1 58-05-9 6006 143
26
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1 50-02-2 5743
27
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Phase 1 1177-87-3
28
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
29
Methotrexate Approved Phase 3,Phase 2,Phase 1 59-05-2, 1959-05-2 126941
30
Hydrocortisone acetate Approved, Vet_approved Phase 3 50-03-3
31
Carmustine Approved, Investigational Phase 3 154-93-8 2578
32
Hydroxyurea Approved Phase 3 127-07-1 3657
33
Melphalan Approved Phase 3,Phase 2,Phase 1 148-82-3 4053 460612
34
Arsenic trioxide Approved, Investigational Phase 2, Phase 3,Phase 1 1327-53-3 518740
35
alemtuzumab Approved, Investigational Phase 2, Phase 3,Phase 1 216503-57-0
36
Azacitidine Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 320-67-2 9444
37
Decitabine Approved, Investigational Phase 3,Phase 2,Phase 1 2353-33-5 451668
38
Midostaurin Approved, Investigational Phase 3 120685-11-2 104937 9829523
39
Tretinoin Approved, Investigational, Nutraceutical Phase 3,Phase 2,Phase 1 302-79-4 5538 444795
40
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1 59-30-3 6037
41
tipifarnib Investigational Phase 3,Phase 2,Phase 1 192185-72-1 159324
42 Staurosporine Experimental Phase 3,Phase 1 62996-74-1
43 Vaccines Phase 3
44 Antimetabolites Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
45 Antiviral Agents Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
46 Etoposide phosphate Phase 3,Phase 2,Phase 1
47 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
48 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
49 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
50 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 183)
# Name Status NCT ID Phase Drugs
1 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4 cyclophosphamide;thiotepa
2 Vaccine Therapy and GM-CSF in Treating Patients With Acute Myeloid Leukemia in Remission Unknown status NCT00454168 Phase 3
3 Combination Chemotherapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Acute Myelogenous Leukemia Unknown status NCT00002549 Phase 3 busulfan;cyclophosphamide;cytarabine;daunorubicin hydrochloride;etoposide;idarubicin;mesna;mitoxantrone hydrochloride
4 Combination Chemotherapy With or Without Monoclonal Antibody Therapy in Treating Patients With Refractory or Relapsed Acute Myelogenous Leukemia Unknown status NCT00006045 Phase 3 cytarabine;etoposide;mitoxantrone hydrochloride
5 Combination Chemotherapy, Biological Therapy, and Bone Marrow Transplantation in Treating Patients With Acute Myeloid Leukemia Unknown status NCT00002658 Phase 3 amsacrine;cyclophosphamide;cytarabine;daunorubicin hydrochloride;etoposide;idarubicin;mitoxantrone hydrochloride;thioguanine;tretinoin
6 Combination Chemotherapy, Interleukin-2, and Peripheral Stem Cell Transplant in Treating Patients With Acute Myeloid Leukemia Unknown status NCT00004128 Phase 3 busulfan;cyclophosphamide;cytarabine;daunorubicin hydrochloride;etoposide
7 Gemtuzumab Ozogamicin in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia Unknown status NCT00091234 Phase 2, Phase 3 gemtuzumab ozogamicin
8 Combination Chemotherapy With or Without PSC 833, Peripheral Stem Cell Transplantation, and/or Interleukin-2 in Treating Patients With Acute Myeloid Leukemia Completed NCT00006363 Phase 3 cytarabine;daunorubicin hydrochloride;etoposide;valspodar;busulfan
9 Caspofungin Acetate or Fluconazole in Preventing Invasive Fungal Infections in Patients With Acute Myeloid Leukemia Who Are Undergoing Chemotherapy Completed NCT01307579 Phase 3 Caspofungin Acetate;Fluconazole
10 Combination Chemotherapy With or Without Gemtuzumab in Treating Young Patients With Newly Diagnosed Acute Myeloid Leukemia Completed NCT00372593 Phase 3 asparaginase;cytarabine;daunorubicin hydrochloride;etoposide;gemtuzumab ozogamicin;mitoxantrone hydrochloride
11 Combination Chemotherapy in Treating Young Patients With Down Syndrome and Acute Myeloid Leukemia or Myelodysplastic Syndromes Completed NCT00369317 Phase 3 asparaginase;daunorubicin hydrochloride;cytarabine;thioguanine;etoposide
12 Combination Chemotherapy With or Without Valspodar in Treating Patients With Previously Untreated Acute Myeloid Leukemia Completed NCT00003190 Phase 3 cytarabine;daunorubicin hydrochloride;etoposide;valspodar
13 Combination Chemotherapy With or Without Filgrastim and/or Tretinoin in Treating Patients With Acute Myeloid Leukemia Completed NCT00005863 Phase 3 cytarabine;daunorubicin hydrochloride;etoposide;fludarabine phosphate;tretinoin
14 Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome Completed NCT00002798 Phase 3 asparaginase;daunorubicin hydrochloride;fludarabine phosphate;therapeutic hydrocortisone;cytarabine;idarubicin;dexamethasone;thioguanine;etoposide;methotrexate;cyclophosphamide;busulfan
15 Tipifarnib in Treating Patients With Acute Myeloid Leukemia in Remission Completed NCT00093470 Phase 3 Tipifarnib
16 Combination Chemotherapy With or Without G-CSF in Treating Older Patients With Acute Myeloid Leukemia Completed NCT00002719 Phase 3 amsacrine;carmustine;cytarabine;etoposide;idarubicin;mitoxantrone hydrochloride
17 flt3L in Treating Patients With Acute Myeloid Leukemia Completed NCT00006223 Phase 3
18 Intensive Compared With Nonintensive Chemotherapy in Treating Older Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome Completed NCT00005823 Phase 3 cytarabine;daunorubicin hydrochloride;etoposide;hydroxyurea;idarubicin;mitoxantrone hydrochloride;thioguanine;tretinoin;valspodar
19 Chemotherapy in Treating Children With Down Syndrome and Myeloproliferative Disorder, Acute Myelogenous Leukemia, or Myelodysplastic Syndrome Completed NCT00003593 Phase 3 asparaginase;cytarabine;daunorubicin hydrochloride;methotrexate;therapeutic hydrocortisone;thioguanine
20 Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome Completed NCT00002517 Phase 3 cytarabine;daunorubicin hydrochloride;dexamethasone;etoposide;idarubicin;mitoxantrone hydrochloride;thioguanine
21 High Dose Chemotherapy, Peripheral Stem Cell Transplantation, and Interleukin-2 in Treating Patients With Acute Myeloid Leukemia Completed NCT00002945 Phase 3 cyclophosphamide;cytarabine;etoposide;idarubicin;melphalan
22 Combination Chemotherapy With or Without Gemtuzumab Ozogamicin or Tipifarnib in Treating Patients With Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndromes Completed NCT00454480 Phase 2, Phase 3 arsenic trioxide;azacitidine;busulfan;clofarabine;cytarabine;daunorubicin hydrochloride;fludarabine phosphate;gemtuzumab ozogamicin;melphalan;tipifarnib
23 Cytarabine and Daunorubicin With or Without Gemtuzumab Ozogamicin in Treating Older Patients With Acute Myeloid Leukemia or Myelodysplastic Syndromes Completed NCT00121303 Phase 3 cytarabine;daunorubicin hydrochloride;gemtuzumab ozogamicin
24 Daunorubicin & Cytarabine +/- Zosuquidar inTreating Older Patients With Newly Diagnosed Acute Myeloid Leukemia or Refractory Anemia Completed NCT00046930 Phase 3 cytarabine;daunorubicin hydrochloride;zosuquidar trihydrochloride;Placebo
25 Cytarabine With or Without VNP40101M in Treating Patients With Relapsed Acute Myeloid Leukemia Completed NCT00112554 Phase 3 cytarabine;laromustine
26 S0106 Cytarabine and Daunorubicin w/ or w/o Gemtuzumab Followed By HD Cytarabine and Either Gemtuzumab or Nothing in de Novo AML Completed NCT00085709 Phase 3 gemtuzumab ozogamicin;Cytosine arabinoside;Daunomycin
27 Chemotherapy With or Without Gemtuzumab Ozogamicin in Treating Older Patients With Acute Myeloid Leukemia Completed NCT00052299 Phase 3 cytarabine;etoposide;gemtuzumab ozogamicin;idarubicin;mitoxantrone hydrochloride
28 Clofarabine or Daunorubicin Hydrochloride and Cytarabine Followed By Decitabine or Observation in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia Active, not recruiting NCT02085408 Phase 3 clofarabine;daunorubicin hydrochloride;cytarabine;decitabine
29 Daunorubicin, Cytarabine, and Midostaurin in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Active, not recruiting NCT00651261 Phase 3 cytarabine;daunorubicin;midostaurin;dexamethasone acetate
30 CAR-pNK Cell Immunotherapy for Relapsed/Refractory CD33+ AML Unknown status NCT02944162 Phase 1, Phase 2
31 Combination Chemotherapy Plus Biological Therapy in Treating Patients With Acute Myelogenous Leukemia Unknown status NCT00003405 Phase 2 amifostine trihydrate;bromodeoxyuridine;cytarabine;idarubicin;idoxuridine;isotretinoin;mitoxantrone hydrochloride
32 Combination Chemotherapy in Treating Patients With Relapsed Acute Myelogenous Leukemia Unknown status NCT00003758 Phase 2 cytarabine;idarubicin
33 Lenalidomide in Treating Older Patients With Acute Myeloid Leukemia Who Have Undergone Stem Cell Transplant Unknown status NCT02038153 Phase 1, Phase 2 Lenalidomide
34 Clofarabine, Cytarabine, and Idarubicin in Treating Patients With Intermediate-Risk or High-Risk Acute Myeloid Leukemia or High-Risk Myelodysplasia Unknown status NCT00838240 Phase 1, Phase 2 clofarabine;cytarabine;idarubicin
35 Imatinib Mesylate in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Who Have Received Chemotherapy Unknown status NCT00509093 Phase 2 imatinib mesylate
36 Monoclonal Antibody in Treating Patients With Acute Myelogenous Leukemia Unknown status NCT00006084 Phase 2
37 VNP40101M Followed by Cytarabine in Treating Older Patients With Acute Myeloid Leukemia Unknown status NCT00354276 Phase 2 cytarabine;laromustine
38 Bortezomib and Combination Chemotherapy in Treating Younger Patients With Recurrent, Refractory, or Secondary Acute Myeloid Leukemia Completed NCT00666588 Phase 2 idarubicin;cytarabine;bortezomib;etoposide
39 High-Dose Busulfan and High-Dose Cyclophosphamide Followed By Donor Bone Marrow Transplant in Treating Patients With Leukemia, Myelodysplastic Syndrome, Multiple Myeloma, or Recurrent Hodgkin or Non-Hodgkin Lymphoma Completed NCT01177371 Phase 2 busulfan;cyclophosphamide;methylprednisolone;methotrexate;cyclosporine
40 Choline Magnesium Trisalicylate and Combination Chemotherapy in Treating Patients With Acute Myeloid Leukemia Completed NCT02144675 Phase 2 choline magnesium trisalicylate;idarubicin;cytarabine
41 CPX-351 in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome Completed NCT02019069 Phase 2 liposomal cytarabine-daunorubicin CPX-351
42 Alvocidib, Cytarabine, and Mitoxantrone Hydrochloride or Cytarabine and Daunorubicin Hydrochloride in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Completed NCT01349972 Phase 2 alvocidib;daunorubicin hydrochloride;mitoxantrone hydrochloride;cytarabine
43 AKT Inhibitor MK-2206 in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia Completed NCT01253447 Phase 2 Akt inhibitor MK2206
44 Early Discharge and Outpatients Care in Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia Previously Treated With Intensive Chemotherapy Completed NCT01235572 Phase 2
45 Vorinostat, Azacitidine, and Gemtuzumab Ozogamicin for Older Patients With Relapsed or Refractory AML Completed NCT00895934 Phase 1, Phase 2 vorinostat;gemtuzumab ozogamicin;azacitidine
46 Donor Stem Cell Transplant or Bone Marrow Transplant in Treating Patients With Acute Myeloid Leukemia in Remission Completed NCT01020734 Phase 2 busulfan;cyclophosphamide;cyclosporine;fludarabine phosphate;methotrexate
47 Comparing Three Different Combination Chemotherapy Regimens in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia Completed NCT00634244 Phase 2 alvocidib;mitoxantrone hydrochloride;carboplatin;cytarabine;sirolimus;etoposide;topotecan hydrochloride
48 Alvocidib, Cytarabine, and Mitoxantrone in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Completed NCT00795002 Phase 2 alvocidib;mitoxantrone hydrochloride;cytarabine
49 Bortezomib, Daunorubicin, and Cytarabine in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia Completed NCT00742625 Phase 1, Phase 2 daunorubicin hydrochloride;cytarabine;bortezomib
50 Tipifarnib and Etoposide in Treating Older Patients With Newly Diagnosed, Previously Untreated Acute Myeloid Leukemia Completed NCT00602771 Phase 2 tipifarnib;etoposide

Search NIH Clinical Center for Acute Myeloblastic Leukemia Without Maturation

Genetic Tests for Acute Myeloblastic Leukemia Without Maturation

Anatomical Context for Acute Myeloblastic Leukemia Without Maturation

MalaCards organs/tissues related to Acute Myeloblastic Leukemia Without Maturation:

41
Myeloid, Bone, Bone Marrow, T Cells

Publications for Acute Myeloblastic Leukemia Without Maturation

Articles related to Acute Myeloblastic Leukemia Without Maturation:

# Title Authors Year
1
A cat with acute myeloblastic leukemia without maturation (M1) treated with combination chemotherapy. ( 16462128 )
2006
2
[Acute myeloblastic leukemia without maturation (AML-M1) with basophilic elements and associated with translocation t(6;9)]. ( 12805015 )
2003
3
Heterogeneity of acute myeloblastic leukemia without maturation: an ultrastructural study. ( 7770965 )
1995
4
t(6;9)(p22;q34) associated with acute myeloblastic leukemia (M1) ( 1423232 )
1992
5
Prognostic significance of myeloperoxidase positivity of blast cells in acute myeloblastic leukemia without maturation (FAB: M1): an ECOG study. ( 2560775 )
1989

Variations for Acute Myeloblastic Leukemia Without Maturation

Expression for Acute Myeloblastic Leukemia Without Maturation

Search GEO for disease gene expression data for Acute Myeloblastic Leukemia Without Maturation.

Pathways for Acute Myeloblastic Leukemia Without Maturation

Pathways related to Acute Myeloblastic Leukemia Without Maturation according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.79 FLT3 NPM1

GO Terms for Acute Myeloblastic Leukemia Without Maturation

Cellular components related to Acute Myeloblastic Leukemia Without Maturation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 8.62 FLT3 NPM1

Biological processes related to Acute Myeloblastic Leukemia Without Maturation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.16 FLT3 NPM1
2 positive regulation of cell proliferation GO:0008284 8.96 FLT3 NPM1
3 viral process GO:0016032 8.62 FLT3 NPM1

Molecular functions related to Acute Myeloblastic Leukemia Without Maturation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 8.62 FLT3 NPM1

Sources for Acute Myeloblastic Leukemia Without Maturation

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