MCID: ACT114
MIFTS: 26

Acute Myeloblastic Leukemia Without Maturation

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Acute Myeloblastic Leukemia Without Maturation

MalaCards integrated aliases for Acute Myeloblastic Leukemia Without Maturation:

Name: Acute Myeloblastic Leukemia Without Maturation 20 58 17
Acute Myeloblastic Leukemia M1 20 58
Aml M1 20 58
Acute Myeloblastic Leukemia Type 1 20

Characteristics:

Orphanet epidemiological data:

58

Classifications:

Orphanet: 58  
Rare haematological diseases


External Ids:

ICD10 via Orphanet 33 C92.0
UMLS via Orphanet 71 C0026998
Orphanet 58 ORPHA98833

Summaries for Acute Myeloblastic Leukemia Without Maturation

GARD : 20 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 98833 Definition A rare, acute myeloid leukemia characterized by no significant myeloid maturation and more than 90% blast cells in the non-erythroid population. Various degrees of anemia, thrombocytopenia, or pancytopenia are present. Frequent clinical manifestations include fatigue, fever, bleeding disorders, and organomegaly, especially hepatosplenomegaly.

MalaCards based summary : Acute Myeloblastic Leukemia Without Maturation, also known as acute myeloblastic leukemia m1, is related to myeloid leukemia and myeloid sarcoma. An important gene associated with Acute Myeloblastic Leukemia Without Maturation is FLT3 (Fms Related Receptor Tyrosine Kinase 3), and among its related pathways/superpathways is Tyrosine Kinases / Adaptors. Affiliated tissues include myeloid, bone marrow and bone.

Wikipedia : 73 Acute myeloblastic leukemia without maturation is a quickly progressing disease in which too many... more...

Related Diseases for Acute Myeloblastic Leukemia Without Maturation

Diseases related to Acute Myeloblastic Leukemia Without Maturation via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 myeloid leukemia 30.1 NPM1 FLT3
2 myeloid sarcoma 29.9 NPM1 FLT3
3 leukemia 29.9 NPM1 FLT3
4 acute myeloblastic leukemia with maturation 29.8 NPM1 FLT3
5 acute leukemia 29.8 NPM1 FLT3
6 myelodysplastic syndrome 29.6 NPM1 FLT3
7 acute megakaryocytic leukemia 29.6 NPM1 FLT3
8 leukemia, acute myeloid 29.5 NPM1 FLT3
9 acute promyelocytic leukemia 29.4 NPM1 FLT3
10 aplastic anemia 10.1
11 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 10.1
12 deficiency anemia 10.1
13 sarcoma 10.1
14 spindle cell sarcoma 10.1
15 hypereosinophilic syndrome 10.1
16 b-lymphoblastic leukemia/lymphoma 9.9
17 disseminated intravascular coagulation 9.9
18 pancytopenia 9.9
19 gingival hypertrophy 9.9
20 chromosomal triplication 9.9
21 cytogenetically normal acute myeloid leukemia 9.8 NPM1 FLT3
22 etv6 thrombocytopenia and predisposition to leukemia 9.8 NPM1 FLT3
23 thrombocytopenia 9.8 NPM1 FLT3
24 cebpa-associated familial acute myeloid leukemia 9.8 NPM1 FLT3
25 childhood acute myeloid leukemia 9.8 NPM1 FLT3
26 bone marrow cancer 9.8 NPM1 FLT3
27 chronic myelomonocytic leukemia 9.8 NPM1 FLT3
28 myelofibrosis 9.7 NPM1 FLT3
29 hematologic cancer 9.7 NPM1 FLT3
30 wilms tumor 1 9.7 NPM1 FLT3
31 lymphoma, non-hodgkin, familial 9.7 NPM1 FLT3
32 fanconi anemia, complementation group a 9.6 NPM1 FLT3

Graphical network of the top 20 diseases related to Acute Myeloblastic Leukemia Without Maturation:



Diseases related to Acute Myeloblastic Leukemia Without Maturation

Symptoms & Phenotypes for Acute Myeloblastic Leukemia Without Maturation

Drugs & Therapeutics for Acute Myeloblastic Leukemia Without Maturation

Search Clinical Trials , NIH Clinical Center for Acute Myeloblastic Leukemia Without Maturation

Genetic Tests for Acute Myeloblastic Leukemia Without Maturation

Anatomical Context for Acute Myeloblastic Leukemia Without Maturation

MalaCards organs/tissues related to Acute Myeloblastic Leukemia Without Maturation:

40
Myeloid, Bone Marrow, Bone, Monocytes, Neutrophil

Publications for Acute Myeloblastic Leukemia Without Maturation

Articles related to Acute Myeloblastic Leukemia Without Maturation:

(show top 50) (show all 192)
# Title Authors PMID Year
1
Detection of a novel CBFB-MYH11 fusion transcript in acute myeloid leukemia M1 with inv(16)(p13q22). 61
31353165 2020
2
Morphological characteristics, cytogenetic profile, and outcome of RUNX1-RUNX1T1-positive acute myeloid leukemia: Experience of an Indian tertiary care center. 61
31725954 2020
3
Challenges associated with limited-resources cancer care facility: Bilateral breast myeloid sarcoma as an example. 61
31788245 2019
4
Role of CD71 in acute leukemia- An immunophenotypic marker for erythroid lineage or proliferation? 61
31361230 2019
5
[Analysis of CDSS Experimental Indexes in 333 Cases of Newly Diagnosed Acute Leukemia]. 61
31204913 2019
6
lncRNA PCAT-1 interacting with FZD6 contributes to the malignancy of acute myeloid leukemia cells through activating Wnt/β-catenin signaling pathway. 61
31814913 2019
7
[Expression of EVI1 in Bone Marrow of Patients with AML and ALL and Its Correlation with Leukemia Subtyping, Clinical Features and Prognosis of Patients]. 61
30295245 2018
8
[Analysis of Clinical and Laboratory Features of Patients with Acute Myeloid Leukemia(AML)-M1/M2 with Cuplike Nuclei Morphology]. 61
30111391 2018
9
Cup-like Blasts in 2 Pediatric Patients With NPM-1-Positive Acute Myeloid Leukemia. 61
29432313 2018
10
Prospective randomization of post-remission therapy comparing autologous peripheral blood stem cell transplantation versus high-dose cytarabine consolidation for acute myelogenous leukemia in first remission. 61
29243031 2018
11
Gene expression profiling of acute myeloid leukemia samples from adult patients with AML-M1 and -M2 through boutique microarrays, real-time PCR and droplet digital PCR. 61
29286103 2018
12
Down syndrome associated childhood myeloid leukemia with yet unreported acquired chromosomal abnormalities and a new potential adverse marker: dup(1)(q25q44). 61
29563973 2018
13
A new adult AML case with an extremely complex karyotype, remission and relapse combined with high hyperdiploidy of a normal chromosome set in secondary AML. 61
30186609 2018
14
A transient cutaneous relapse of AML M1 in hematological remission: a case report. 61
29264902 2017
15
[FLT3 Gene Expression and Its Clinical Significance in Acute Myeloid Leukemia.] 61
28598126 2016
16
Immunohistochemical Detection of NPM1 Mutation in Acute Myeloid Leukemia and its Association With Cup-like Nuclear Morphology of Blasts. 61
26200838 2016
17
Acute Myeloid Leukemia: Clinical Spectrum of 125 Patients. 61
26838239 2016
18
A Case Report of Concurrent IDH1 and NPM1 Mutations in a Novel t(X;2)(q28;p22) Translocation in Acute Myeloid Leukaemia without Maturation (AML-M1). 61
28239274 2015
19
Decitabine as a conditioning regimen in haploidentical stem cell transplantation for refractory acute myeloid leukaemia. 61
25825260 2015
20
[Expression of CD71 on cell proliferation in hematologic malignancy and its correlation with Ki-67]. 61
25687079 2015
21
Pediatric donor cell leukemia after allogeneic hematopoietic stem cell transplantation in AML patient from related donor. 61
25674158 2015
22
[An unusual cause of febrile neutropenia: brucellosis]. 61
25492662 2014
23
Geographic heterogeneity of the AML1-ETO fusion gene in Iranian patients with acute myeloid leukemia. 61
26989731 2014
24
[Clinical characteristics and therapeutic efficacy of normal karyotype AML patients with CEBPA mutation]. 61
24598643 2014
25
Esterase D and gamma 1 actin level might predict results of induction therapy in patients with acute myeloid leukemia without and with maturation. 61
24085543 2013
26
Novel t(7;10)(p22;p24) along with NPM1 mutation in patient with relapsed acute myeloid leukemia. 61
24413869 2013
27
MiR-99a may serve as a potential oncogene in pediatric myeloid leukemia. 61
24191888 2013
28
KLF4 translation level is associated with differentiation stage of different pediatric leukemias in both cell lines and primary samples. 61
22592916 2013
29
Identification of homogeneously staining regions in leukemia patients. 61
24124438 2013
30
Association of cup-like nuclei in blasts with FLT3 and NPM1 mutations in acute myeloid leukemia. 61
23238897 2013
31
[Clinical characteristics in adult acute myeloid leukemia with isocitrate dehydrogenase gene mutation]. 61
23755812 2013
32
The Frequency and clinical significance of IDH1 mutations in Chinese acute myeloid leukemia patients. 61
24376688 2013
33
Expression of immune inhibitory receptor ILT3 in acute myeloid leukemia with monocytic differentiation. 61
23027709 2013
34
A New Case of dic(1;15)(p11;p11) in AML M1: Apropos of a Case and a Review of the Literature. 61
23533845 2013
35
A novel RUNX1-C11orf41 fusion gene in a case of acute myeloid leukemia with a t(11;21)(p14;q22). 61
23102734 2012
36
Comparative proteome analysis of acute myeloid leukemia with and without maturation. 61
22850270 2012
37
Acute myeloblastic leukemia with associated BCR-ABL translocation in a dog. 61
22747755 2012
38
Profiling three-dimensional nuclear telomeric architecture of myelodysplastic syndromes and acute myeloid leukemia defines patient subgroups. 61
22539801 2012
39
Epidermal growth factor receptor expression in acute myelogenous leukaemia is associated with clinical prognosis. 61
22674781 2012
40
[Successful treatment with reduced-intensity cord blood transplantation for acute myeloid leukemia with complete tetraploidy (92, XXXX)]. 61
21471699 2011
41
The HPB-AML-I cell line possesses the properties of mesenchymal stem cells. 61
21144016 2010
42
[Expression of NF-kappaB mRNA in acute myeloid leukemia]. 61
20416168 2010
43
A novel approach to treatment in childhood acute myeloblastic leukemia and myelodysplastic syndrome with high-dose methylprednisolone as a differentiation- and apoptosis-inducing agent of myeloid leukemic cells. 61
27265790 2010
44
[Pyogenic spondylitis following unrelated hematopoietic stem cell transplantation]. 61
20068278 2009
45
Cuplike nuclei (prominent nuclear invaginations) in acute myeloid leukemia are highly associated with FLT3 internal tandem duplication and NPM1 mutation. 61
19672946 2009
46
A new recurring chromosome 13 abnormality in two older patients with de novo acute myeloid leukemia: An Indian experience. 61
21088719 2009
47
Recurring mutations found by sequencing an acute myeloid leukemia genome. 61
19657110 2009
48
Immunologic characteristics and prognosis of myelodysplastic syndrome new subtype: refractory anemia with excess blasts-II. 61
19236759 2009
49
Jumping translocations in hematological malignancies: a cytogenetic study of five cases. 61
19027489 2008
50
K313dup is a recurrent CEBPA mutation in de novo acute myeloid leukemia (AML). 61
18587575 2008

Variations for Acute Myeloblastic Leukemia Without Maturation

Expression for Acute Myeloblastic Leukemia Without Maturation

Search GEO for disease gene expression data for Acute Myeloblastic Leukemia Without Maturation.

Pathways for Acute Myeloblastic Leukemia Without Maturation

Pathways related to Acute Myeloblastic Leukemia Without Maturation according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.79 NPM1 FLT3

GO Terms for Acute Myeloblastic Leukemia Without Maturation

Cellular components related to Acute Myeloblastic Leukemia Without Maturation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 8.62 NPM1 FLT3

Biological processes related to Acute Myeloblastic Leukemia Without Maturation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 8.96 NPM1 FLT3
2 positive regulation of cell proliferation GO:0008284 8.62 NPM1 FLT3

Sources for Acute Myeloblastic Leukemia Without Maturation

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45 MESH via Orphanet
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49 NCI
50 NCIt
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53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
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69 Tocris
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71 UMLS via Orphanet
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