MCID: ACT179
MIFTS: 13

Acute Myeloid Leukemia with 11q23 Abnormalities

Categories: Blood diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Acute Myeloid Leukemia with 11q23 Abnormalities

MalaCards integrated aliases for Acute Myeloid Leukemia with 11q23 Abnormalities:

Name: Acute Myeloid Leukemia with 11q23 Abnormalities 59
Aml with 11q23 Abnormalities 59

Characteristics:

Orphanet epidemiological data:

59

Classifications:



External Ids:

Orphanet 59 ORPHA98831
UMLS via Orphanet 74 C1292775
ICD10 via Orphanet 34 C92.6

Summaries for Acute Myeloid Leukemia with 11q23 Abnormalities

MalaCards based summary : Acute Myeloid Leukemia with 11q23 Abnormalities, also known as aml with 11q23 abnormalities, is related to leukemia, acute myeloid and leukemia. An important gene associated with Acute Myeloid Leukemia with 11q23 Abnormalities is KMT2A (Lysine Methyltransferase 2A). The drugs Dacarbazine and Temozolomide have been mentioned in the context of this disorder. Affiliated tissues include myeloid.

Related Diseases for Acute Myeloid Leukemia with 11q23 Abnormalities

Diseases related to Acute Myeloid Leukemia with 11q23 Abnormalities via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 leukemia, acute myeloid 10.0
2 leukemia 10.0
3 myeloid leukemia 10.0

Symptoms & Phenotypes for Acute Myeloid Leukemia with 11q23 Abnormalities

Drugs & Therapeutics for Acute Myeloid Leukemia with 11q23 Abnormalities

Drugs for Acute Myeloid Leukemia with 11q23 Abnormalities (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166
2
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
3
Vorinostat Approved, Investigational Phase 2 149647-78-9 5311
4 Alkylating Agents Phase 2
5 Histone Deacetylase Inhibitors Phase 2
6 Antineoplastic Agents, Alkylating Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase 2 Temozolomide Plus Vorinostat in Relapse/Refractory Acute Myeloid Leukemia (AML) Completed NCT01550224 Phase 2 Temozolomide;Vorinostat

Search NIH Clinical Center for Acute Myeloid Leukemia with 11q23 Abnormalities

Genetic Tests for Acute Myeloid Leukemia with 11q23 Abnormalities

Anatomical Context for Acute Myeloid Leukemia with 11q23 Abnormalities

MalaCards organs/tissues related to Acute Myeloid Leukemia with 11q23 Abnormalities:

41
Myeloid

Publications for Acute Myeloid Leukemia with 11q23 Abnormalities

Articles related to Acute Myeloid Leukemia with 11q23 Abnormalities:

# Title Authors Year
1
Allogeneic hematopoietic cell transplantation in adult acute myeloid leukemia with 11q23 abnormality: a retrospective study of the Adult Acute Myeloid Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation (JSHCT). ( 29978286 )
2018

Variations for Acute Myeloid Leukemia with 11q23 Abnormalities

Expression for Acute Myeloid Leukemia with 11q23 Abnormalities

Search GEO for disease gene expression data for Acute Myeloid Leukemia with 11q23 Abnormalities.

Pathways for Acute Myeloid Leukemia with 11q23 Abnormalities

GO Terms for Acute Myeloid Leukemia with 11q23 Abnormalities

Sources for Acute Myeloid Leukemia with 11q23 Abnormalities

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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