AMMOL
MCID: ACT193
MIFTS: 59

Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22) (AMMOL)

Categories: Blood diseases, Bone diseases, Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

MalaCards integrated aliases for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22):

Name: Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22) 53 59
Acute Myelomonocytic Leukemia 53 59 29 73
Aml with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22) 53 59
Aml M4 53 59
Ammol 53 59
Aml with Inv(16)(p13.1q22) or T(16;16)(p13.1;q22) 53
Acute Myeloblastic Leukemia Type 4 53
Leukemia, Acute Myelomonocytic 13
Leukemia Myelomonocytic Acute 55
Cbfb-Myh11 53
Aml-M4 53

Characteristics:

Orphanet epidemiological data:

59
acute myelomonocytic leukemia
Inheritance: Not applicable; Age of onset: Adult;

Classifications:



External Ids:

ICD10 via Orphanet 34 C92.5
MESH via Orphanet 45 D015479
UMLS via Orphanet 74 C0023479
ICD10 33 C92.5
UMLS 73 C0023479

Summaries for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

NIH Rare Diseases : 53 Acute myelomonocytic leukemia (AMML) is a cancer that typically develops in the bone marrow and blood of older individuals.  AMML is one type of acute myeloid leukemia, a group of blood cancers that occur when the amount of white blood cells increases rapidly.  Symptoms of AMML often include fatigue (due to anemia) or easy bruising or bleeding (due to thrombocytopenia).  The cause of AMML is currently unknown.  Treatment typically consists of chemotherapy.

MalaCards based summary : Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22), also known as acute myelomonocytic leukemia, is related to leukemia and myeloid sarcoma, and has symptoms including fever and fatigue. An important gene associated with Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22) is CBFB (Core-Binding Factor Subunit Beta), and among its related pathways/superpathways are PAK Pathway and PI3K-Akt signaling pathway. Affiliated tissues include myeloid, bone and bone marrow, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

Diseases related to Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22) via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
# Related Disease Score Top Affiliating Genes
1 leukemia 31.0 CREBBP ETV6 FLT3 KIT RUNX1
2 myeloid sarcoma 30.1 DNTT FLT3 KIT KMT2A MPO
3 ring chromosome 21 30.0 ETV6 KMT2A
4 lymphocytic leukemia 29.9 DNTT ETV6 KMT2A RUNX1
5 acute promyelocytic leukemia 29.7 CSF1R FLT3 MPO RUNX1
6 leukemia, acute monocytic 29.7 CREBBP KMT2A MPO
7 aleukemic leukemia cutis 29.6 FLT3 MPO MYH11 RUNX1
8 malignant histiocytosis 29.4 CSF1 CSF1R
9 chronic myelomonocytic leukemia 29.3 CSF1 ETV6 FLT3 KIT RUNX1
10 leukemia, acute lymphoblastic 29.3 DNTT ETV6 FLT3 KMT2A RUNX1
11 leukemia, acute myeloid 29.2 CBFB CSF1R DNTT ETV6 FLT3 KIT
12 myeloid leukemia 29.2 CBFB CREBBP ETV6 FLT3 KIT MYH11
13 leukemia, chronic myeloid 29.1 DNTT ETV6 FLT3 KIT KMT2A MPO
14 acute leukemia 28.5 CREBBP DNTT ETV6 FLT3 KIT KMT2A
15 myelodysplastic syndrome 28.5 CREBBP CSF1 CSF1R DNTT ETV6 FLT3
16 sarcoma 10.4
17 myeloma, multiple 10.3
18 acute myeloblastic leukemia with maturation 10.2 FLT3 KIT
19 lymphoma 10.2
20 acute myeloid leukemia with minimal differentiation 10.2 FLT3 MPO
21 mast-cell sarcoma 10.1 KIT MPO
22 cytogenetically normal acute myeloid leukemia 10.1 FLT3 KMT2A
23 chronic eosinophilic leukemia 10.1 FLT3 KIT
24 uterine inversion 10.1 CSF1R KIT
25 mycosis fungoides 10.1
26 vasculitis 10.1
27 acute basophilic leukemia 10.1 ETV6 MPO
28 polymorphous low-grade adenocarcinoma 10.1 KIT MYH11
29 congenital mesoblastic nephroma 10.1 ETV6 KIT
30 b-cell childhood acute lymphoblastic leukemia 10.0 ETV6 RUNX1
31 tetrasomy 21 10.0 DNTT RUNX1
32 neonatal leukemia 10.0 CREBBP FLT3
33 leukemia, chronic lymphocytic 2 10.0
34 leukemia, chronic lymphocytic 10.0
35 fanconi anemia, complementation group a 10.0
36 leukostasis 10.0
37 macroglobulinemia 10.0
38 hypereosinophilic syndrome 10.0
39 leukemia, b-cell, chronic 10.0
40 pdgfrb-associated chronic eosinophilic leukemia 10.0
41 platelet disorder, familial, with associated myeloid malignancy 10.0 ETV6 RUNX1
42 lymphoid leukemia 10.0 ETV6 FLT3 KMT2A
43 graft-versus-host disease 10.0
44 acute graft versus host disease 10.0
45 xp22.3 microdeletion syndrome 10.0
46 acute myeloid leukemia with t(8;21)(q22;q22) translocation 10.0 FLT3 KIT RUNX1
47 8p11 myeloproliferative syndrome 10.0 FLT3 KIT RUNX1
48 dendritic cell tumor 10.0 DNTT MPO
49 acute biphenotypic leukemia 10.0 DNTT KMT2A MPO
50 malignant mesenchymoma 10.0 ETV6 KIT

Graphical network of the top 20 diseases related to Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22):



Diseases related to Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22)

Symptoms & Phenotypes for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

UMLS symptoms related to Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22):


fever, fatigue

GenomeRNAi Phenotypes related to Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22) according to GeneCards Suite gene sharing:

26 (show all 32)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.4 MPO
2 Increased shRNA abundance (Z-score > 2) GR00366-A-102 10.4 DNTT FLT3 KIT
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.4 FLT3
4 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.4 FLT3
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.4 FLT3
6 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.4 FLT3
7 Increased shRNA abundance (Z-score > 2) GR00366-A-123 10.4 DNTT FLT3
8 Increased shRNA abundance (Z-score > 2) GR00366-A-126 10.4 MPO
9 Increased shRNA abundance (Z-score > 2) GR00366-A-138 10.4 DNTT
10 Increased shRNA abundance (Z-score > 2) GR00366-A-151 10.4 DNTT
11 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.4 KIT
12 Increased shRNA abundance (Z-score > 2) GR00366-A-157 10.4 DNTT KIT MPO
13 Increased shRNA abundance (Z-score > 2) GR00366-A-16 10.4 DNTT
14 Increased shRNA abundance (Z-score > 2) GR00366-A-163 10.4 FLT3
15 Increased shRNA abundance (Z-score > 2) GR00366-A-170 10.4 KIT
16 Increased shRNA abundance (Z-score > 2) GR00366-A-176 10.4 MPO
17 Increased shRNA abundance (Z-score > 2) GR00366-A-182 10.4 DNTT
18 Increased shRNA abundance (Z-score > 2) GR00366-A-186 10.4 MPO
19 Increased shRNA abundance (Z-score > 2) GR00366-A-197 10.4 DNTT
20 Increased shRNA abundance (Z-score > 2) GR00366-A-25 10.4 FLT3
21 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.4 MPO
22 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.4 KIT
23 Increased shRNA abundance (Z-score > 2) GR00366-A-36 10.4 MPO
24 Increased shRNA abundance (Z-score > 2) GR00366-A-42 10.4 KIT
25 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.4 MPO
26 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.4 MPO
27 Increased shRNA abundance (Z-score > 2) GR00366-A-70 10.4 FLT3 MPO
28 Increased shRNA abundance (Z-score > 2) GR00366-A-73 10.4 DNTT
29 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.4 KIT
30 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.4 KIT
31 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.4 KIT
32 Reduced mammosphere formation GR00396-S 9.02 CSF1 CSF1R ETV6 KMT2A RUNX1

MGI Mouse Phenotypes related to Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22):

46 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.29 CBFB CREBBP CSF1 CSF1R DNTT ETV6
2 cardiovascular system MP:0005385 10.28 CBFB CREBBP CSF1 DNTT ETV6 KIT
3 cellular MP:0005384 10.27 CBFB CREBBP CSF1 CSF1R ETV6 FLT3
4 hematopoietic system MP:0005397 10.26 CBFB CREBBP CSF1 CSF1R DNTT ETV6
5 growth/size/body region MP:0005378 10.24 CBFB CREBBP CSF1 CSF1R ETV6 FLT3
6 immune system MP:0005387 10.24 CBFB CREBBP CSF1 CSF1R DNTT ETV6
7 endocrine/exocrine gland MP:0005379 10.15 CBFB CREBBP CSF1 CSF1R ETV6 FLT3
8 mortality/aging MP:0010768 10.14 CBFB CREBBP CSF1 CSF1R ETV6 FLT3
9 integument MP:0010771 10.13 CBFB CREBBP CSF1 CSF1R ETV6 KIT
10 craniofacial MP:0005382 10.04 CBFB CREBBP CSF1 CSF1R KIT KMT2A
11 embryo MP:0005380 10.03 CBFB CREBBP ETV6 KIT KMT2A RUNX1
12 limbs/digits/tail MP:0005371 9.93 CBFB CREBBP CSF1 CSF1R KIT KMT2A
13 liver/biliary system MP:0005370 9.91 CBFB CREBBP CSF1 KIT KMT2A RUNX1
14 neoplasm MP:0002006 9.87 CBFB CREBBP ETV6 FLT3 KIT KMT2A
15 no phenotypic analysis MP:0003012 9.86 CBFB CSF1 CSF1R ETV6 FLT3 KIT
16 muscle MP:0005369 9.85 CREBBP CSF1 KIT KMT2A MPO MYH11
17 normal MP:0002873 9.76 CBFB CREBBP CSF1R DNTT ETV6 KIT
18 respiratory system MP:0005388 9.43 CBFB CREBBP CSF1 KIT MYH11 RUNX1
19 skeleton MP:0005390 9.23 CBFB CREBBP CSF1 CSF1R FLT3 KIT

Drugs & Therapeutics for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

Search Clinical Trials , NIH Clinical Center for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22)

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

Genetic tests related to Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22):

# Genetic test Affiliating Genes
1 Acute Myelomonocytic Leukemia 29

Anatomical Context for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

MalaCards organs/tissues related to Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22):

41
Myeloid, Bone, Bone Marrow, T Cells, Monocytes, Lung, B Cells

Publications for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

Articles related to Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22):

(show top 50) (show all 293)
# Title Authors Year
1
A Case of Granulocytic Sarcoma or Extramedullary Acute Myelomonocytic Leukemia of the Gallbladder. ( 30352989 )
2018
2
t(9;19)(q22;p13) in Acute Myelomonocytic Leukemia. ( 29391333 )
2018
3
Sequential strategy for umbilical cord blood transplantation in a Korean Fanconi anemia girl with refractory acute myelomonocytic leukemia and complex karyotype. ( 27976485 )
2017
4
Clinical and prognostic significance of eosinophilia and inv(16)/t(16;16) in pediatric acute myelomonocytic leukemia (AML-M4). ( 28371234 )
2017
5
NUP98 Rearrangement in Acute Myelomonocytic Leukemia With t(11;19)(p15;p12): The First Case Report Worldwide. ( 28224778 )
2017
6
Facial Diplegia as Initial Manifestation of Acute, Myelomonocytic Leukemia with Isolated Trisomy 47, XY,+11[14]/46, XY[6]. ( 28694633 )
2017
7
Orbital myxoma comorbid with acute myelomonocytic leukemia. ( 28812920 )
2017
8
Presentation of Gallbladder Chloroma in B-Mode Imaging and Contrast-Enhanced Ultrasound (CEUS) in a Patient with Acute Myelomonocytic Leukemia (AML M5). ( 29226275 )
2017
9
Human NUP98-IQCG fusion protein induces acute myelomonocytic leukemia in mice by dysregulating the Hox/Pbx3 pathway. ( 26675333 )
2016
10
Acute myelomonocytic leukemia and leukocytoclastic vasculitis. ( 28029561 )
2016
11
Identification of a Cryptic Insertion ins(11;X)(q23;q28q12) Resulting in a KMT2A-FLNA Fusion in a 13-Month-Old Child with Acute Myelomonocytic Leukemia. ( 28253492 )
2016
12
Cardiopulmonary Failure Requiring ECMO Bypass Resulting from Leukemia Cell Lysis in a Patient with Childhood Acute Myelomonocytic Leukemia. ( 26124967 )
2015
13
A novel mutation of SETBP1 in atypical chronic myeloid leukemia transformed from acute myelomonocytic leukemia. ( 26185647 )
2015
14
MLL-ELL fusion gene in an acute myelomonocytic leukemia patient transformed from acute promyelocytic leukemia. ( 26185637 )
2015
15
Cochlear implantation in a patient with acute myelomonocytic leukemia before allogeneic peripheral blood stem cell transplantation. ( 24560096 )
2014
16
Targeted ex vivo reduction of CD64-positive monocytes in chronic myelomonocytic leukemia and acute myelomonocytic leukemia using human granzyme B-based cytolytic fusion proteins. ( 24523193 )
2014
17
A novel fusion of SQSTM1 and FGFR1 in a patient with acute myelomonocytic leukemia with t(5;8)(q35;p11) translocation. ( 25501022 )
2014
18
Bilateral Adrenal Masses in a Patient in Remission From Acute Myelomonocytic Leukemia. ( 24566206 )
2014
19
RANBP2-ALK fusion combined with monosomy 7 in acute myelomonocytic leukemia. ( 24613277 )
2014
20
Interaction Between Myelomonocytic and Lymphoid Cells in a Patient with Acute MyeloMonocytic Leukemia and Chronic Lymphocytic Leukemia. ( 23987820 )
2013
21
Interdigitating dendritic cell sarcoma presenting simultaneously with acute myelomonocytic leukemia: report of a rare case and literature review. ( 23605368 )
2013
22
Leukemic ascites as an initial presentation of acute myelomonocytic leukemia with inversion of chromosome 16. ( 23563011 )
2013
23
Thrombomodulin-induced differentiation of acute myelomonocytic leukemia cells via JNK signaling. ( 22342852 )
2012
24
Acute myelomonocytic leukemia presenting with gingival enlargement as the only clinical manifestation. ( 23493961 )
2012
25
Establishment and characterization of a new human acute myelomonocytic leukemia cell line JIH-3. ( 22340903 )
2012
26
p210 BCR/ABL1 as a secondary change in a patient with acute myelomonocytic leukemia (M4Eo) with inv(16). ( 23054652 )
2012
27
Myeloid Sarcoma and Acute Myelomonocytic Leukemia in an Adolescent with Tetrasomy 8: Staging with (18)F-FDG PET/CT. ( 24900045 )
2012
28
Acute myelomonocytic leukemia (AML-M4) in a dog with the extradural lesion. ( 21060242 )
2011
29
CD7-positive acute myelomonocytic leukemia with trisomy 21 as a sole acquired chromosomal abnormality in two adolescents. ( 21592571 )
2011
30
Double supernumerary isochromosome 4p in acute myelomonocytic leukemia. ( 20863564 )
2010
31
Isolated central nervous system relapse in an adolescent with acute myelomonocytic leukemia, Charcot Marie Tooth syndrome, and paraneoplastic autoantibody. ( 20724950 )
2010
32
Myeloid sarcoma in the nasal cavities that developed during the course of acute myelomonocytic leukemia. ( 21123976 )
2010
33
Acute Shoulder Monoarthritis in a Patient With Acute Myelomonocytic Leukemia With Novel Translocation t(5;13). ( 29147181 )
2010
34
Pseudo Chediak-Higashi anomaly in acute myelomonocytic leukemia. ( 19332932 )
2009
35
Genome profiling of acute myelomonocytic leukemia: alteration of the MYB locus in MYST3-linked cases. ( 18818702 )
2009
36
Gemtuzumab ozogamicin-induced long-term remission in a woman with acute myelomonocytic leukemia and bone marrow relapse following allogeneic transplantation. ( 19904520 )
2009
37
Treatment-related acute myelomonocytic leukemia with t(11;19) in a child following chemotherapy for hepatoblastoma. ( 17973320 )
2008
38
A dog with acute myelomonocytic leukemia. ( 18628605 )
2008
39
Systemic mastocytosis with acute myelomonocytic leukemia: a case report. ( 23100960 )
2008
40
Comparative analysis of genes regulated in acute myelomonocytic leukemia with and without inv(16)(p13q22) using microarray techniques, real-time PCR, immunohistochemistry, and flow cytometry immunophenotyping. ( 17571080 )
2007
41
Mesenteric chloroma with t(16;16) followed by acute myelomonocytic leukemia with clonal evolution. ( 18036407 )
2007
42
Rare t(1;11)(q23;p15) in therapy-related myelodysplastic syndrome evolving into acute myelomonocytic leukemia: a case report and review of the literature. ( 17889707 )
2007
43
Parotid involvement in acute myelomonocytic leukemia. ( 17978464 )
2007
44
[Depressing the immune escape of acute myelomonocytic leukemia via an anti-Fas ribozyme]. ( 17096877 )
2006
45
Establishment of a stroma-dependent human acute myelomonocytic leukemia cell line, NAMO-2, with FLT3 tandem duplication. ( 17118759 )
2006
46
Dup(1)(p31.2p36.2) in acute myelomonocytic leukemia. ( 16490603 )
2006
47
Acute myelomonocytic leukemia in a boy with LEOPARD syndrome (PTPN11 gene mutation positive). ( 16679933 )
2006
48
Acute myelomonocytic leukemia with abnormal eosinophils: a case report with multi-modality diagnostic work-up. ( 17214400 )
2006
49
[Immunophenotypic and cytogenetic features of acute myelomonocytic leukemia]. ( 17059770 )
2006
50
Acute myelomonocytic leukemia with dysplastic bone marrow eosinophils showing t(5;17)(q13;q11) and a secondary chromosomal aberration, inv(16)(p13q22). ( 17189222 )
2006

Variations for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

Expression for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

Search GEO for disease gene expression data for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22).

Pathways for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

Pathways related to Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22) according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.04 CREBBP CSF1 CSF1R KIT MYH11
2
Show member pathways
12.75 CREBBP CSF1 CSF1R FLT3 KIT
3 12.6 CREBBP CSF1R FLT3 KIT RUNX1
4
Show member pathways
12.54 CREBBP CSF1R FLT3 KIT MPO RUNX1
5 12.53 CSF1 CSF1R FLT3 KIT
6
Show member pathways
12.48 CSF1 CSF1R FLT3 KIT
7 11.89 CSF1R FLT3 KIT
8 11.77 CSF1 FLT3 KIT MPO
9 11.45 CREBBP CSF1R KIT MPO
10 11.37 CSF1R ETV6 FLT3 KMT2A MPO RUNX1
11 11.34 CSF1 CSF1R DNTT FLT3 KIT
12 11.33 CSF1 CSF1R FLT3 KIT
13 11.31 CSF1 CSF1R KIT
14
Show member pathways
11.23 CREBBP CSF1 CSF1R
15 10.89 CREBBP ETV6 FLT3
16 10.77 CSF1 CSF1R FLT3 KIT
17 10.73 CSF1 MPO
18 10.45 CBFB RUNX1

GO Terms for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

Cellular components related to Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22) according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 9.33 CSF1R FLT3 KIT
2 core-binding factor complex GO:0016513 8.96 CBFB RUNX1
3 CSF1-CSF1R complex GO:1990682 8.62 CSF1 CSF1R

Biological processes related to Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22) according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 transcription by RNA polymerase II GO:0006366 9.96 CBFB ETV6 KMT2A RUNX1
2 negative regulation of apoptotic process GO:0043066 9.95 CSF1R FLT3 KIT MPO
3 positive regulation of cell proliferation GO:0008284 9.94 CSF1 CSF1R FLT3 KIT
4 positive regulation of cell migration GO:0030335 9.83 CSF1 CSF1R KIT
5 cytokine-mediated signaling pathway GO:0019221 9.81 CSF1 CSF1R FLT3 KIT
6 peptidyl-tyrosine phosphorylation GO:0018108 9.8 CSF1R FLT3 KIT
7 protein autophosphorylation GO:0046777 9.79 CSF1R FLT3 KIT
8 positive regulation of MAPK cascade GO:0043410 9.78 CSF1R FLT3 KIT
9 negative regulation of signal transduction GO:0009968 9.73 CSF1R FLT3 KIT
10 regulation of Wnt signaling pathway GO:0030111 9.65 CBFB RUNX1
11 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.65 CSF1R FLT3 KIT
12 osteoclast differentiation GO:0030316 9.63 CSF1 CSF1R
13 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.63 FLT3 KIT
14 regulation of megakaryocyte differentiation GO:0045652 9.63 CBFB KMT2A RUNX1
15 macrophage differentiation GO:0030225 9.6 CSF1 CSF1R
16 embryonic hemopoiesis GO:0035162 9.59 KIT KMT2A
17 regulation of intracellular estrogen receptor signaling pathway GO:0033146 9.58 CBFB RUNX1
18 regulation of keratinocyte differentiation GO:0045616 9.58 CBFB RUNX1
19 regulation of regulatory T cell differentiation GO:0045589 9.57 CBFB RUNX1
20 hematopoietic stem cell proliferation GO:0071425 9.55 ETV6 RUNX1
21 regulation of bicellular tight junction assembly GO:2000810 9.54 CBFB RUNX1
22 regulation of B cell receptor signaling pathway GO:0050855 9.52 CBFB RUNX1
23 regulation of cytokine-mediated signaling pathway GO:0001959 9.49 CBFB RUNX1
24 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.46 CSF1 CSF1R FLT3 KIT
25 myeloid progenitor cell differentiation GO:0002318 9.43 FLT3 KIT
26 regulation of hematopoietic stem cell differentiation GO:1902036 9.43 CBFB KMT2A RUNX1
27 macrophage colony-stimulating factor signaling pathway GO:0038145 9.4 CSF1 CSF1R
28 negative regulation of CD4-positive, alpha-beta T cell differentiation GO:0043371 9.37 CBFB RUNX1
29 positive regulation of CD8-positive, alpha-beta T cell differentiation GO:0043378 9.32 CBFB RUNX1
30 regulation of myeloid cell differentiation GO:0045637 9.13 CBFB CREBBP RUNX1
31 hemopoiesis GO:0030097 9.02 CSF1 CSF1R FLT3 KIT RUNX1
32 positive regulation of transcription by RNA polymerase II GO:0045944 10.04 CBFB CREBBP ETV6 KMT2A RUNX1
33 cell differentiation GO:0030154 10.01 CSF1 CSF1R ETV6 FLT3 KIT

Molecular functions related to Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22) according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transferase activity GO:0016740 9.8 CREBBP CSF1R DNTT FLT3 KIT KMT2A
2 DNA-binding transcription factor activity GO:0003700 9.55 CBFB CREBBP ETV6 KMT2A RUNX1
3 transmembrane signaling receptor activity GO:0004888 9.54 CSF1R FLT3 KIT
4 cytokine binding GO:0019955 9.43 CSF1R KIT
5 protein tyrosine kinase activity GO:0004713 9.43 CSF1R FLT3 KIT
6 protein homodimerization activity GO:0042803 9.35 CSF1 CSF1R FLT3 KIT KMT2A
7 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.8 CSF1R FLT3 KIT
8 protein binding GO:0005515 10.14 CBFB CREBBP CSF1 CSF1R DNTT ETV6

Sources for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

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