MCID: ACT196
MIFTS: 15

Acute Myeloid Leukemia with Inv3(p21;q26.2) or T(3;3)(p21;q26.2)

Categories: Blood diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Acute Myeloid Leukemia with Inv3(p21;q26.2) or T(3;3)(p21;q26.2)

MalaCards integrated aliases for Acute Myeloid Leukemia with Inv3(p21;q26.2) or T(3;3)(p21;q26.2):

Name: Acute Myeloid Leukemia with Inv3(p21;q26.2) or T(3;3)(p21;q26.2) 20
Acute Myeloid Leukemia with Inv(3)(q21q26.2) or T(3;3)(q21;q26.2) 20 58
Aml with Inv(3)(q21q26.2) or T(3;3)(q21;q26.2) 20 58
Acute Myeloid Leukemia with Inv3(q21;q26.2) or T(3;3)(q21;q26.2) 20
Aml with Inv3(p21;q26.2) or T(3;3)(p21;q26.2) 20
Aml with Inv3(q21;q26.2) or T(3;3)(q21;q26.2) 20

Classifications:

Orphanet: 58  
Rare haematological diseases


External Ids:

ICD10 via Orphanet 33 C92.0
Orphanet 58 ORPHA402020

Summaries for Acute Myeloid Leukemia with Inv3(p21;q26.2) or T(3;3)(p21;q26.2)

GARD : 20 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 402020 Definition A subtype of acute myeloid leukemia with recurrent genetic abnormalities characterized by clonal proliferation of myeloid blasts in the bone marrow, blood and, rarely, other tissues. Bone marrow typically shows small, hypolobated megakaryocytes and multilineage dyslplasia. Patients typically present with leukocytosis, anemia, variable platelet counts and a variety of nonspecific symptoms related to ineffective hematopoesis (fatigue, bleeding, bruising, recurrent infections, bone pain) and/or extramedullary site involvement (gingivitis, splenomegaly). High resistance to conventional chemotherapy is reported.

MalaCards based summary : Acute Myeloid Leukemia with Inv3(p21;q26.2) or T(3;3)(p21;q26.2), also known as acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2), is related to leukemia, acute myeloid and myeloid leukemia. An important gene associated with Acute Myeloid Leukemia with Inv3(p21;q26.2) or T(3;3)(p21;q26.2) is MECOM (MDS1 And EVI1 Complex Locus). Affiliated tissues include myeloid, bone and bone marrow.

Related Diseases for Acute Myeloid Leukemia with Inv3(p21;q26.2) or T(3;3)(p21;q26.2)

Diseases related to Acute Myeloid Leukemia with Inv3(p21;q26.2) or T(3;3)(p21;q26.2) via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 leukemia, acute myeloid 11.0
2 myeloid leukemia 11.0
3 myelodysplastic syndrome 10.8
4 leukemia 10.8
5 thrombocytosis 10.7
6 monocytic leukemia 10.7

Graphical network of the top 20 diseases related to Acute Myeloid Leukemia with Inv3(p21;q26.2) or T(3;3)(p21;q26.2):



Diseases related to Acute Myeloid Leukemia with Inv3(p21;q26.2) or T(3;3)(p21;q26.2)

Symptoms & Phenotypes for Acute Myeloid Leukemia with Inv3(p21;q26.2) or T(3;3)(p21;q26.2)

Drugs & Therapeutics for Acute Myeloid Leukemia with Inv3(p21;q26.2) or T(3;3)(p21;q26.2)

Search Clinical Trials , NIH Clinical Center for Acute Myeloid Leukemia with Inv3(p21;q26.2) or T(3;3)(p21;q26.2)

Genetic Tests for Acute Myeloid Leukemia with Inv3(p21;q26.2) or T(3;3)(p21;q26.2)

Anatomical Context for Acute Myeloid Leukemia with Inv3(p21;q26.2) or T(3;3)(p21;q26.2)

MalaCards organs/tissues related to Acute Myeloid Leukemia with Inv3(p21;q26.2) or T(3;3)(p21;q26.2):

40
Myeloid, Bone, Bone Marrow

Publications for Acute Myeloid Leukemia with Inv3(p21;q26.2) or T(3;3)(p21;q26.2)

Articles related to Acute Myeloid Leukemia with Inv3(p21;q26.2) or T(3;3)(p21;q26.2):

# Title Authors PMID Year
1
Acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2): Clinical and biological features and comparison with other acute myeloid leukemias with cytogenetic aberrations involving long arm of chromosome 3. 61
25680074 2015
2
Myelodysplastic syndrome with inv(3)(q21q26.2) or t(3;3)(q21;q26.2) has a high risk for progression to acute myeloid leukemia. 61
21757602 2011

Variations for Acute Myeloid Leukemia with Inv3(p21;q26.2) or T(3;3)(p21;q26.2)

Expression for Acute Myeloid Leukemia with Inv3(p21;q26.2) or T(3;3)(p21;q26.2)

Search GEO for disease gene expression data for Acute Myeloid Leukemia with Inv3(p21;q26.2) or T(3;3)(p21;q26.2).

Pathways for Acute Myeloid Leukemia with Inv3(p21;q26.2) or T(3;3)(p21;q26.2)

GO Terms for Acute Myeloid Leukemia with Inv3(p21;q26.2) or T(3;3)(p21;q26.2)

Molecular functions related to Acute Myeloid Leukemia with Inv3(p21;q26.2) or T(3;3)(p21;q26.2) according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transferase activity GO:0016740 8.62 RPN1 MECOM

Sources for Acute Myeloid Leukemia with Inv3(p21;q26.2) or T(3;3)(p21;q26.2)

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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